11 results on '"Corney D"'
Search Results
2. Gene Editing/Gene Therapies: A NOVEL METHOD FOR ASSESSING FULL-LENGTH SEQUENCE INTEGRITY OF RNA THERAPEUTICS
- Author
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Wu, H., primary, Chen, Y., additional, Leung, C., additional, Corney, D., additional, O’Hara, A., additional, DeVito, I., additional, Turner, L., additional, Mozdzierz, C., additional, Latif, H., additional, and Zhou, G., additional
- Published
- 2022
- Full Text
- View/download PDF
3. THE GEOSTATIONARY EARTH RADIATION BUDGET PROJECT
- Author
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Harries, J. E., Russell, J. E., Hanafin, J. A., Brindley, H., Futyan, J., Rufus, J., Kellock, S., Matthews, G., Wrigley, R., Last, A., Mueller, J., Mossavati, R., Ashmall, J., Sawyer, E., Parker, D., Caldwell, M., Allan, P. M., Smith, A., Bates, M. J., Coan, B., Stewart, B. C., Lepine, D. R., Cornwall, L. A., Corney, D. R., Ricketts, M. J., Drummond, D., Smart, D., Cutler, R., Dewitte, S., Clerbaux, N., Gonzalez, L., Ipe, A., Bertrand, C., Joukoff, A., Crommelynck, D., Nelms, N., Llewellyn-Jones, D. T., Butcher, G., Smith, G. L., Szewczyk, Z. P., Mlynczak, P. E., Slingo, A., Allan, R. P., and Ringer, M. A.
- Published
- 2005
4. Architectures and methodologies for future deployment of multi-site Zettabyte-Exascale data handling platforms
- Author
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Acín, V, primary, Bird, I, additional, Boccali, T, additional, Cancio, G, additional, Collier, I P, additional, Corney, D, additional, Delaunay, B, additional, Delfino, M, additional, dell'Agnello, L, additional, Flix, J, additional, Fuhrmann, P, additional, Gasthuber, M, additional, Gülzow, V, additional, Heiss, A, additional, Lamanna, G, additional, Macchi, P-E, additional, Maggi, M, additional, Matthews, B, additional, Neissner, C, additional, Nief, J-Y, additional, Porto, M C, additional, Sansum, A, additional, Schulz, M, additional, and Shiers, J, additional
- Published
- 2015
- Full Text
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5. Mining Newsorthy Topics from Social Media
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Martin, C., Corney, D., Goker, A. S., and MacFarlane, A.
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QA75 ,Z665 - Abstract
Newsworthy stories are increasingly being shared through social networking platforms such as Twitter and Reddit, and journal-ists now use them to rapidly discover stories and eye-witness accounts. We present a technique that detects “bursts” of phrases on Twitter that is designed for a real-time topic-detection system. We describe a time-dependent variant of the classic tf-idf approach and group together bursty phrases that often appear in the same messages in order to identify emerging topics. We demonstrate our methods by analysing tweets corresponding to events drawn from the worlds of politics and sport. We created a user-centred “ground truth” to evaluate our methods, based on mainstream media accounts of the events. This helps ensure our methods remain practical. We compare several clustering and topic ranking methods to discover the characteristics of news-related collections, and show tha t different strategies are needed to detect emerging topics within them. We show that our methods successfully detect a range of different topics for each event and can retrieve messages (for example, tweets) that represent each topic for the user.
- Published
- 2013
6. BioRAT: extracting biological information from full-length papers
- Author
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Corney, D. P. A., Buxton, B. F., Langdon, W. B., and Jones, D. T.
- Abstract
Motivation: Converting the vast quantity of free-format text found in journals into a concise, structured format makes the researcher's quest for information easier. Recently, several information extraction systems have been developed that attempt to simplify the retrieval and analysis of biological and medical data. Most of this work has used the abstract alone, owing to the convenience of access and the quality of data. Abstracts are generally available through central collections with easy direct access (e.g. PubMed). The full-text papers contain more information, but are distributed across many locations (e.g. publishers' web sites, journal web sites and local repositories), making access more difficult. In this paper, we present BioRAT, a new information extraction (IE) tool, specifically designed to perform biomedical IE, and which is able to locate and analyse both abstracts and full-length papers. BioRAT is a Biological Research Assistant for Text mining, and incorporates a document search ability with domain-specific IE. Results: We show first, that BioRAT performs as well as existing systems, when applied to abstracts; and second, that significantly more information is available to BioRAT through the full-length papers than via the abstracts alone. Typically, less than half of the available information is extracted from the abstract, with the majority coming from the body of each paper. Overall, BioRAT recalled 20.31% of the target facts from the abstracts with 55.07% precision, and achieved 43.6% recall with 51.25% precision on full-length papers. Availability: The software and documentation can be found at http://bioinf.cs.ucl.ac.uk/biorat
- Published
- 2004
7. Submicroscopic 8pter deletion, mild mental retardation, and behavioral problems caused by a familial t(8;20)(p23;p13).
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Vries, L.B.A. de, Lees, M., Knight, S.J., Regan, R., Corney, D., Flint, J., Barnicoat, A., Winter, R.M., Vries, L.B.A. de, Lees, M., Knight, S.J., Regan, R., Corney, D., Flint, J., Barnicoat, A., and Winter, R.M.
- Abstract
Item does not contain fulltext, Microscopically visible distal 8p deletions have been associated with growth and mental impairment, minor facial anomalies, congenital heart defects, and behavioral problems. We report two cousins with mild retardation and behavioral problems, including inappropriate sexual behavior and pyromania. Familial learning difficulties on the grandfather's side incompatible with Mendelian inheritance prompted telomere screening, which detected a submicroscopic terminal 8p deletion of < 5.1 Mb. The cousins' mothers both carried a t(8;20)(p23;p13) balanced translocation. The frequently observed microcephaly in patients with microscopically visible deletions of 8pter is lacking in both cousins, suggesting that the gene(s) causing the microcephaly is centromeric to the deleted region. The absence of cardiac defects in the cousins confirms the more proximal location of gene(s) causing these abnormalities in other reported cases with microscopically visible 8pter deletions and supports involvement of the GATA4 gene. Moreover, the current cases predict the presence of a putative gene(s) involved in behavior in the most telomeric 5.1 Mb of the p-arm of chromosome 8. This first clinical report of a submicroscopic subtelomeric 8p deletion gives more insight into the so-called 8p- syndrome and demonstrates the difficulty in making a clinical diagnosis for a submicroscopic 8pter deletion in an individual patient with mental retardation.
- Published
- 2001
8. 604 - Gene Editing/Gene Therapies: A NOVEL METHOD FOR ASSESSING FULL-LENGTH SEQUENCE INTEGRITY OF RNA THERAPEUTICS.
- Author
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Wu, H., Chen, Y., Leung, C., Corney, D., O'Hara, A., DeVito, I., Turner, L., Mozdzierz, C., Latif, H., and Zhou, G.
- Subjects
- *
GENOME editing , *GENE therapy , *THERAPEUTICS - Published
- 2022
- Full Text
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9. What do people hospitalised with COVID-19 think about their care? Results of a satisfaction survey during the first wave of COVID-19 in Liverpool.
- Author
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Wu MS, Watson R, Hayat F, Ratcliffe L, Beadsworth MB, McKenna M, Corney D, Plum C, Macfarlane JL, Matareed M, Butt S, Gupta S, Hine P, Defres S, and Wingfield T
- Abstract
Despite huge advances in vaccines, testing and treatments for COVID-19, there is negligible evidence on the perceptions of people hospitalised with COVID-19 about the care they received. To address this, we developed a satisfaction survey for people with COVID-19 admitted to our hospital during the first COVID-19 wave in Liverpool. Of those invited, 98/160 (61%) responded, of whom 94/98 (96%) completed the survey. Respondents rated overall care highly (mean 4.7/5) and 89/94 (95%) reported that they would recommend the hospital to friends and/or family. Most respondents felt safe on the ward (94%), with privacy maintained (93%) and pain well managed (90%). Fewer than two-thirds (63%) of respondents considered themselves adequately consulted regarding medications and side effects. Sleep and food/drink quality were also highlighted as areas for improvement. To overcome the issues raised, we generated a 'COVID-19 practice pointers' poster within an integrated educational bundle on COVID-19 wards. The impact of the bundle on perceptions of people hospitalised with COVID-19 will be evaluated in people hospitalised with COVID-19 in Liverpool in 2021. Whether hospitalised for COVID-19 or other conditions, our survey results are a timely reminder of the importance of involving patients in shaping the care that they receive., (© Royal College of Physicians 2021. All rights reserved.)
- Published
- 2021
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10. The brightness of colour.
- Author
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Corney D, Haynes JD, Rees G, and Lotto RB
- Subjects
- Brain Mapping, Humans, Lighting, Magnetic Resonance Imaging, Models, Biological, Color Perception physiology, Contrast Sensitivity physiology
- Abstract
Background: The perception of brightness depends on spatial context: the same stimulus can appear light or dark depending on what surrounds it. A less well-known but equally important contextual phenomenon is that the colour of a stimulus can also alter its brightness. Specifically, stimuli that are more saturated (i.e. purer in colour) appear brighter than stimuli that are less saturated at the same luminance. Similarly, stimuli that are red or blue appear brighter than equiluminant yellow and green stimuli. This non-linear relationship between stimulus intensity and brightness, called the Helmholtz-Kohlrausch (HK) effect, was first described in the nineteenth century but has never been explained. Here, we take advantage of the relative simplicity of this 'illusion' to explain it and contextual effects more generally, by using a simple Bayesian ideal observer model of the human visual ecology. We also use fMRI brain scans to identify the neural correlates of brightness without changing the spatial context of the stimulus, which has complicated the interpretation of related fMRI studies., Results: Rather than modelling human vision directly, we use a Bayesian ideal observer to model human visual ecology. We show that the HK effect is a result of encoding the non-linear statistical relationship between retinal images and natural scenes that would have been experienced by the human visual system in the past. We further show that the complexity of this relationship is due to the response functions of the cone photoreceptors, which themselves are thought to represent an efficient solution to encoding the statistics of images. Finally, we show that the locus of the response to the relationship between images and scenes lies in the primary visual cortex (V1), if not earlier in the visual system, since the brightness of colours (as opposed to their luminance) accords with activity in V1 as measured with fMRI., Conclusions: The data suggest that perceptions of brightness represent a robust visual response to the likely sources of stimuli, as determined, in this instance, by the known statistical relationship between scenes and their retinal responses. While the responses of the early visual system (receptors in this case) may represent specifically the statistics of images, post receptor responses are more likely represent the statistical relationship between images and scenes. A corollary of this suggestion is that the visual cortex is adapted to relate the retinal image to behaviour given the statistics of its past interactions with the sources of retinal images: the visual cortex is adapted to the signals it receives from the eyes, and not directly to the world beyond.
- Published
- 2009
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11. What are lightness illusions and why do we see them?
- Author
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Corney D and Lotto RB
- Subjects
- Humans, Artificial Intelligence, Biomimetics methods, Image Interpretation, Computer-Assisted methods, Nerve Net physiology, Optical Illusions physiology, Photometry methods, Visual Perception physiology
- Abstract
Lightness illusions are fundamental to human perception, and yet why we see them is still the focus of much research. Here we address the question by modelling not human physiology or perception directly as is typically the case but our natural visual world and the need for robust behaviour. Artificial neural networks were trained to predict the reflectance of surfaces in a synthetic ecology consisting of 3-D "dead-leaves" scenes under non-uniform illumination. The networks learned to solve this task accurately and robustly given only ambiguous sense data. In addition--and as a direct consequence of their experience--the networks also made systematic "errors" in their behaviour commensurate with human illusions, which includes brightness contrast and assimilation--although assimilation (specifically White's illusion) only emerged when the virtual ecology included 3-D, as opposed to 2-D scenes. Subtle variations in these illusions, also found in human perception, were observed, such as the asymmetry of brightness contrast. These data suggest that "illusions" arise in humans because (i) natural stimuli are ambiguous, and (ii) this ambiguity is resolved empirically by encoding the statistical relationship between images and scenes in past visual experience. Since resolving stimulus ambiguity is a challenge faced by all visual systems, a corollary of these findings is that human illusions must be experienced by all visual animals regardless of their particular neural machinery. The data also provide a more formal definition of illusion: the condition in which the true source of a stimulus differs from what is its most likely (and thus perceived) source. As such, illusions are not fundamentally different from non-illusory percepts, all being direct manifestations of the statistical relationship between images and scenes.
- Published
- 2007
- Full Text
- View/download PDF
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