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7. Regulation of the production of granulocyte-macrophage colony-stimulating factor by macrophage-like tumour cell lines

Author

Hume, David A., Summers, Kim M., Cohen, Donna R., and Allan, William

Abstract

Macrophage tumour cell lines (PU5-1.8, P388D1) produced detectable granulocyte macrophage colonystimulating (CSF-2) activity measured using a factor-dependent cell line FDC-P1. The production ofCSF-2 was enhanced by endotoxin and inhibited by serum, and correlated inversely with [ 3H]TdR incorporation. mRNA isolated from PU5-1.8 or P388D1 cells initiated CSF-2 production when injected into Xenopus laevisoocytes. The specific activity in this assay was unaltered in mRNA isolated from endotoxin-treated cells. The results suggest that endotoxin acts at a post-transcriptional level.

Published
1985
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