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Sheep farming plays a significant role in generating economic opportunities and employment on a global scale. It is a vital support system for rural economies, mainly where agricultural alternatives are scarce, like farmers living in arid and semiarid areas. This article aims to investigate and promote sustainable communal sheep farming practices and examine the significance of the weaning percentage and how it determines the communal wool industry's success, economic viability, and sustainability. Additionally, the article will address the challenges these farmers face in sweet-, sourand mixed grass veld types. Furthermore, the article will explore the impact of lambing seasons and flock structures on ewe productivity and identify strategies to mitigate adverse effects in communal sheep flocks. Lastly, the article will discuss management practices in sheep production systems, considering their economic and environmental sustainability. The mean weaning percentage, a critical indicator of reproductive success and productivity, was 48.78%, reflecting substantial dispersion within a sample population of 9 603 sheep across 351 farmers' interviews. Pure breeding exhibits a 5.6% higher weaning percentage than crossbreeding. In cases where there was inbreeding, the weaning percentage was 11.3% lower than that of flocks using unrelated rams. Statistical analysis further underscores the substantial influence (p<0.001) of consistent dissemination of production and reproduction technical information, facilitated through governmental initiatives and stakeholder engagements, in driving these improvements. Best sheep and health management practices are paramount for enhancing the weaning percentage of sheep flocks. The quality of grazing and the utilisation of well-adapted breeding stock are pivotal factors. Statistical analysis reveals a significant impact (p<0.05) of rotational grazing with a herding effect (extensive grazing) compared to free grazing (continuous grazing) with minimal management. Integrating labourers into communal sheep enterprises profoundly influences various operations, notably sheep herding, where they safeguard animals, identify health issues, and guide flock movements to optimal grazing areas, enhancing nutrition and weaning percentages. [ABSTRACT FROM AUTHOR]

In South Africa, recent government plans to change the institutional landscape of higher education have resulted in mergers of colleges into universities or technikons. The research reported in this article focuses solely on the impact of a "college-into-university'' incorporation as manifested in the personal, emotional and career experiences of these college staff members. It traces the changes in their perceptions and emotions during and after the incorporation process. It also identifies recurring themes and issues evident in the personal lives of those affected by this incorporation. A unique research methodology was engaged: The College staff who had been appointed to the university after the merger, identified seven critical themes and then designed and conducted 30 semi-structured interviews among themselves. This article thus documents the impact of incorporation into a university on the individual and collective lives of there searchers themselves. The data suggest that the emotional impact of incorporation was intense and that the uncertainty, especially, led to considerable trauma. The most important concern emanating from this joint research project is that while a certain degree of distress is unavoidable in any institutional merger, inattention to the management of human resources, emotions and aspirations could linger on, possibly having a negative effect on the ambitions for the transformation of the new entity.

Background: Pneumocystis jiroveci pneumonia is still a common cause of severe disease in HIV-infected infants <5 months of age. Despite attention to the prevention of mother-to-child transmission programme in South Africa (SA), HIV testing remains incomplete and infants are still at risk. The management of Pneumocystis pneumonia requires ventilation strategies and combination antibiotics. Methods: A prospective but open intervention was performed on all HIV-exposed patients admitted with severe pneumonia to the paediatric intensive care unit (PICU) at Steve Biko Academic Hospital, SA, during a 3-year period from January 2009 to December 2011. All patients were treated with ampicillin, amikacin, co-trimoxazole, prednisone and intravenous gancilovir. Highly active antiretroviral therapy (HAART) was initiated in the PICU as soon as tuberculosis was excluded and HIV status confirmed with an HIV viral load (VL). Routine blood and tracheal specimens were cultured for bacteria and tested by direct fluorescent antigen testing for P. jiroveci. Cytomegalovirus (CMV) VL was tested. All infants were ventilated in a standard fashion and none were oscillated. Results: A total of 87 patients were admitted during the 3-year period. Of these, 29 patients were excluded from the study because they were HIV-unexposed. Ten patients died during the 3-year period. In a multivariate analysis of the presence or absence of P. jiroveci, HIV VL, CD4 count, timing of HAART initiation and CMV VL, no single factor was documented to influence mortality. Conclusion: Mortality from Pneumocystis pneumonia continues to decrease in this PICU. No single factor is responsible and yet all therapeutic strategies contribute to survival. A national policy and guideline is urgently required. [ABSTRACT FROM AUTHOR]

The response of Namaqua Afrikaner, Dorper and South African Mutton Merino lambs, of approximately four months of age, towards a human being situated between them and their flock mates was studied in an arena test. The objective of the study was to determine whether the unimproved Namaqua Afrikaner, with an arguably shorter history of selection, would react differently to humans in an arena test compared to commercial breeds. A total number of 305 animals, born in 2010 and 2011 and raised under extensive veld conditions, were assessed in a modified arena test when the lambs born in each year were approximately four months old. From the test results it was possible to calculate the following parameters of the behaviour of the sheep: (i) The mean distance from the human operator, (ii) the time a lamb spent in a specific zone situated either close to or far from the human, and (iii) the total number of boundaries crossed, which gives an indication of the total distance travelled by an individual lamb. Other data recorded were the number of bleats and the number of times an animal urinated or defecated. There were no significant sex and birth type differences for any of the behaviour traits. No conclusive breed differences were found for any of the traits describing the behaviour of the lambs, except for the number of bleats. Namaqua Afrikaner lambs bleated significantly (24.0 ± 1.2) more in the three minute testing period than Dorper (8.2 ± 0.9) and South African Mutton Merino lambs (11.9 ± 2.5). Further research is necessary to see if this slight indication of anxiety could be related to other traits such as lamb survival or product quality. [ABSTRACT FROM AUTHOR]

The production performance of ewes was assessed in a terminal crossbreeding experiment involving five Merino and Merino-type dam lines and two terminal crossbreeding sire breeds. Dam lines were SA Mutton Merino (SAMM), SAMM rams crossed to Merino ewes (SAMM cross), Dohne Merino, as well as specialist Merino lines selected for clean fleece weight (FW+) and for an increased reproduction (Rep+). Dormer and Suffolk rams were used as sires. Dual-purpose ewes were heavier than Merinos on average and at the ultimate joining at 3.5 years. Average clean fleece weight for SAMM ewes was approximately half that of Merino ewes while clean fleece weights for Dohne and SAMM cross ewes were intermediate. Differences between progeny in slaughter age, marketing weight, dressing percentage and carcass weight could largely be attributed to the comparison of purebred Merino lines with dual-purpose lines. The slaughter age of lambs from the two Merino lines was between 14 and 21% higher than that of the dual-purpose lines. Lambs from purebred SA Mutton Merino (SAMM) dams also outperformed lambs from SAMM cross ewes for slaughter age, slaughter weight and carcass weight. Considerable variation was found between dam lines for reproduction parameters, but few significant differences were found. Lamb output, defined as total weight of lamb slaughtered per joining, averaged 42.7 kg for SAMM ewes, 44.2 kg for SAMM cross ewes, 39.3 kg for Dohne ewes, 32.9 kg for FW+ Merino ewes and 42.0 kg for Rep+ Merino ewes, but differences between lines only tended to be significant. Sire breed did not affect lamb performance or ewe productivity markedly. An economic simulation indicated large differences in gross income per small stock unit between dam lines, warranting further research on the efficiency of terminal Merino-type dam lines. [ABSTRACT FROM AUTHOR]

Carcass data of 114 19-month-old Merino sheep descended from two lines that were divergently selected for maternal multiple rearing ability (H and L lines, respectively) were used. In study A only ram progeny of the same age were slaughtered, while ewes and rams of the respective selection lines were included in study B. Study A: Mean slaughter weight of H line rams was 12% heavier than that of L line contemporaries. A corresponding difference of 13% was found for carcass weight. Carcass component weights, body measurements, retail cut weights and eye-muscle areas were higher in the H line than in the L line, barring a few exceptions. Adjustment for the higher slaughter weight resulted in most of the line differences being eliminated, but the difference in the loin retail cut remained in favour of the H line. Study B: Mean slaughter and carcass weights of H line animals were respectively 7% and 11% heavier than that of L line contemporaries. Adjustment for the higher slaughter weights of H line animals resulted in most of the differences in the retail cut weight being eliminated, but the hindquarters of H line animals remained heavier than that of L line contemporaries. Line did not affect the moisture, protein, lipid or ash content of the M. longissimus dorsi toracis in study B. The effect of gender on the retail cut weights and proximate analysis was consistent with results from the literature. Selection for multiple rearing ability did not result in any unfavourable responses in retail cut weights or meat chemical properties. Carcasses in the H line, in fact, yielded better in the highly priced loin and hindquarters areas, independently of slaughter weight. [ABSTRACT FROM AUTHOR]

The body composition, carcass characteristics and retail cuts of 61 Dormers (21 rams and 40 ewes) and 35 South African Mutton Merinos (SAMM) (17 rams and 18 ewes) were determined. A range of carcass measurements was recorded. Since there was no sex x breed interaction, only main effects of breed and sex were considered. There were no differences in slaughter weight between Dormer and SAMM sheep at 18 months of age. Dormers had a 2.7% point higher dressing percentage and a 6.2% higher carcass weight than the SAMM. The Dormer had a higher fat content (kidney fat, back-fat depth) than the SAMM. The eyemuscle area of the Dormers was 13% larger than that of the SAMM sheep. Rams were heavier than the ewes at slaughter. All the traits measured, indicated advantages in favour of rams. Only the saturated, monounsaturated fatty acids and polyunsaturated fatty acids to saturated fatty acids ratio differed significantly between the Dormer and SAMM sheep. Based on the fatty acid profile, SAMM meat is slightly healthier than that of Dormer sheep. The higher retail cut weights of Dormers suggested that they were superior to the SAMM as far as meat production was concerned. [ABSTRACT FROM AUTHOR]

This study details the production performance of ewes and lambs that originated from a terminal crossbreeding experiment that involved five Merino type dam lines and two terminal crossbreeding sire lines from 1999 to 2002. Ewe lines were SA Mutton Merino (SAMM), SAMM rams crossed to Merino ewes (SAMM cross), Dohne Merino, as well as specialist Merino lines selected for clean fleece weight (FW+) and for an increased reproduction rate (Rep+). Dormer and Suffolk rams were used as sire breeds on these ewes. Data include 777 birth and 605 weaning records of lambs and 562 production year records of ewes. At birth the progeny of SAMM ewes were heavier than those of the other ewe lines, while FW+ ewes produced smaller lambs at birth than SAMM cross and Rep+ ewes. Lamb survival was not significantly affected by ewe line or sire breed. The progeny of the dual-purpose ewe lines (SAMM, SAMM cross and Dohne Merino) were heavier than those of Merino ewes (FW+ and Rep+) at weaning. No sire breed difference was found for birth or weaning weight. The joining weights of dual-purpose ewe lines were higher than those of Merinos. Although considerable variation was found between ewe lines in terms of lamb output (number or weight of lamb weaned per ewe joined), the only significant difference was for weight of lamb weaned between SAMM cross and FW+ Merino ewes. Means for weight of lamb weaned per joining (in kg) were 37.3 for SAMM ewes, 39.6 for SAMM cross ewes, 35.5 for Dohne Merino ewes, 28.9 for FW+ ewes and 34.6 for Rep+ ewes. No differences in ewe reproduction were found between ewes joined to Dormer or Suffolk rams. The clean wool production of SAMM ewes amounted to 46% of that recorded in FW+ ewes. Corresponding percentages were 68% for SAMM cross ewes, 74% for Dohne Merino ewes and 90% for Rep+ ewes. The wool of SAMM ewes was slightly coarser in diameter than those of SAMM cross and FW+ ewes, which in turn was coarser than those of Rep+ and Dohne Merino ewes. The economic... [ABSTRACT FROM AUTHOR]

This study evaluated the differences in the muscle-fat-bone yield of Namaqua Afrikaner (NA), Dorper (D) and SA Mutton Merino (SAMM) ram lambs. The breeds constituted an indigenous, hardy and late maturing, fat-tailed breed (NA), an early maturing, commercial meat breed (D) and a late maturing commercial dual-purpose breed (SAMM). Lambs were slaughtered at 35 (± 8) days post weaning. Carcasses were cooled for 24 h, separated into retail cuts (leg, loin, rib, and shoulder), weighed and deboned. Meat and fat were separated after deboning and weighed to calculate the muscle-fat-bone yield per cut. Least-square means were computed for the respective breeds, using slaughter age as covariate. Results for percentage meat indicate that, with exception of the rib, retail cuts from the NA breed contained a lower percentage of meat than D and SAMM breeds, particularly in the valuable loin and leg cuts. The shoulder of the NA had a lower percentage meat than that of the D. The percentage fat in retail cuts did not differ between breeds for any of the cuts. In comparison with both D and SAMM, NA contained a higher percentage bone in all cuts. Dorper and SAMM carcasses did not differ in terms of the percentage of bone, fat or muscle for any of the retail cuts. The lower meat yield, particularly in the more expensive loin and leg of the NA, when compared to the commercial meat breed (D) could make the former less preferred for meat production. However, the NA compared more favourably than the dual-purpose SAMM. Differences in carcass composition could be attributed to the fact that the NA is an unimproved and late maturing sheep breed. [ABSTRACT FROM AUTHOR]

Merino lines that were divergently selected from the same base population from 1986 to 2009 for their ability to rear multiples were assessed for dag score in autumn and spring, breech wrinkle score, and crutching time. Animals in the Low (L) line had higher dag and breech wrinkle scores and took longer to be crutched than High (H) line contemporaries. Expressed relative to H line least squares means, means of L line individuals were respectively 54%, 65%, 42% and 40% higher for autumn dag score, spring dag score, breech fold score, and crutching time. Gender effects for dag score were inconclusive, as ewe hoggets were more daggy than rams in autumn, with an opposite trend in spring. Shearer (n = 6) also affected crutching times, with an almost twofold difference in mean crutching time from the quickest shearer (27.7 ± 3.1 seconds) to the slowest shearer (49.4 ±3.7 seconds). The inclusion of dag score and breech wrinkle score as linear covariates in an analysis on crutching time eliminated the effect of selection line. It thus seems that the quicker crutching times of H line animals may be related to line differences for dag score and, to a lesser extent, for breech wrinkle score. [ABSTRACT FROM AUTHOR]

Antimicrobial resistance (AMR) poses a global threat, partly fueled by antimicrobial overuse. Paediatric inpatients are particularly vulnerable to infections, leading to high antimicrobial consumption. In low-to-middle income countries (LMICs) like South Africa, research on antimicrobial usage for neonatal and paediatric healthcare-associated infections (HAI) is limited. This cross-sectional study evaluated antimicrobial usage in three academic public sector hospitals in South Africa to improve appropriateness. 22.9% of hospitalised children received at least one prescribed antimicrobial, with neonates, infants, and adolescents having higher prescription rates for HAIs. Common antimicrobials prescribed included beta-lactamase sensitive penicillin, aminoglycosides, and carbapenems. Antimicrobial selection aligned with the WHO AWaRe classification system. HIV infection did not emerge as a risk factor for HAIs or excessive antimicrobial usage. The policy brief recommends several strategies, summarized by the acronym 'PRACTICE,' to optimize antimicrobial prescribing practices. These include implementing standardized policies for empiric antimicrobial use, routine review of antimicrobial therapy, age-specific antimicrobial stewardship programs, and continued collaborative efforts and research. Individualized treatment plans, improved infection prevention and control measures, ongoing surveillance, and exploring electronic technology for antimicrobial stewardship are also crucial. Addressing antimicrobial usage is imperative to combat the growing threat of AMR and improve patient outcomes in LMICs like South Africa.

Objectives: South Africa implemented a National Strategic Framework to optimise antimicrobial stewardship in 2014; however, there is limited data on how this has affected prescribing, especially to children treated in academic centres., Methods: We conducted a point prevalence survey using the World Health Organization (WHO) methodology to evaluate antibiotic and antifungal prescribing practices in paediatric departments at three academic hospitals in South Africa., Results: We recorded 1946 antimicrobial prescriptions in 1191 children, with 55.2% and 39.2% of the antibiotics classified as WHO AWaRe Access and Watch drugs, respectively. There were significant differences in prescription of Reserve antibiotics and antifungals between institutions. Receipt of WHO Watch and Reserve antibiotics was independently associated with infancy (<12 months) and adolescents (13-17 years) (adjusted relative risk [aRR]: 2.09-9.95); prolonged hospitalisation (aRR: 3.29-30.08); rapidly or ultimately fatal illness (aRR: 1.94 to 5.52); and blood transfusion (aRR: 3.28-5.70). Antifungal prescribing was associated with treatment of hospital-associated infection (aRR: 2.90), medical prophylaxis (aRR: 3.30), and treatment in intensive care units (aRR: 2.15-2.27)., Conclusions: Guidance on optimisation of infection prevention and control practice and strengthening of antimicrobial stewardship would impact positively on the care of sick children in our setting., Competing Interests: DPM was, in part, supported by a grant awarded by the Carnegie Corporation of New York. For the remaining authors none were declared., (© 2023 The Author(s).)

Background: The importance of a child's first 1000 days has now been widely accepted by the medical fraternity. Yet, we do not know much about caring practices in low-resource settings., Aim: This study aimed to investigate the caring capabilities of mothers in a low-resource setting., Method: In this study, in-depth interviews were conducted with 18 mothers with children aged 30 months or younger to better understand the arrangements, means and ends that inform developmental health in a low-resource setting in South Africa. The study was conducted in a low-income area, the former black township of Mangaung in Bloemfontein. The mothers were recruited via pamphlets, and two interviews followed. Because of Covid-19, interviews took place via mobile phones, in Sesotho, the local language in the area. Trained fieldworkers conducted, translated and transcribed the interviews. We used thematic analysis and the capabilities approach as the theoretical framework to analyse the responses from the mothers., Findings: We used the following organizing themes: pregnancy and ante-natal care, nutrition, cognitive and physical development, the home environment and access to health care. Although short-term reactions to pregnancy were often negative, the longer-term responses showed that the respondents have agency. Most of them could change their nutrition habits, breastfeed and receive adequate nutrition support from the public health system. Most experienced joy when their children reached milestones (cognitive and others), although they became anxious if milestones were not reached. They emphasized children's play and had dreams for their children's futures. Technology was often mentioned as playing a role in their children's development. A large proportion of the respondents had disrupted homes (because of absent or abusive fathers), but some had stable homes. Most of them showed substantial capability to overcome adverse home environments. The public health system helped them deal with their health problems and their children's health problems, although it also created anxiety in many cases. Our data show how they develop their capabilities and overcome obstacles organically in the face of resource limitations. Despite pregnancies being unexpected and unplanned and fathers being absent, the respondents accepted the pregnancy, adjusted their diets and social behaviour, showed agency by attending primary healthcare facilities and ensured that their children received the required vaccinations. Their extended families played an important role in providing care. Despite the sacrifices, the respondents expressed joy and helped their children function by eating, playing, socializing, learning and using their senses., Conclusion: Our sample of mothers have the agency to adapt to the demands of parenthood and childcare and overcome adversity. Our data support the notion that mothers are held disproportionately and unfairly responsible for achieving the first 1000 days ideals. Despite considerable curtailment of their functionings and capabilities, they nevertheless showed agency to ensure their health and their children's health. A holistic approach should consider these findings in designing policy interventions for children's developmental health., Patient and Public Contribution: We used paid fieldworkers to interact with the research participants., (© 2022 The Authors. Health Expectations published by John Wiley & Sons Ltd.)

This contribution reports for the first time the possibility of using radiolysis to engineer stable efficient nanofluids which exhibit an enhanced thermal conductivity. The validation was confirmed on Ag-H 2 O and Ag-C 2 H 6 O 2 nanofluids fabricated via g-radiolysis within the mild dose range of 0.95 × 10 3 -2.45 × 10 3 Gray. The enhanced thermal conductivity of Ag-H 2 O and Ag-C 2 H 6 O 2 nanofluids, was found to be g-radiations dose dependent. In the latter case of Ag-C 2 H 6 O 2 nanofluid, the relative enhancement in the temperature range of 25-50 °C was found to be 8.89%, 11.54%, 18.69%, 23.57% and 18.45% for D 1  = 0.95 × 10 3 Gray, D 2  = 1.2 × 10 3 Gray, D 3  = 1.54 × 10 3 Gray, D 4  = 1.80 × 10 3 Gray and D 5  = 2.45 × 10 3 Gray respectively. Yet not optimized, an enhancement of the effective thermal conductivity as much as 23.57% relatively to pure C 2 H 6 O 2 was observed in stable Ag-C 2 H 6 O 2 nanofluids. Equivalent results were obtained with Ag-H 2 O., (© 2022. The Author(s).)

Research investigating the link between housing and health often produces mixed results. It does not always prove that good housing improves health. The results suggest a complex set of factors play a role, and the findings are sometimes contradictory. Two ways of addressing these concerns are longitudinal research, where the relationship between housing and health is measured in the short and medium terms, and a focus on children. We use the children's housing and health data from the five waves of the National Income and Distribution Survey (NIDS) survey in South Africa, 2008 to 2017. We investigate the effect that continued living in informal housing over the five waves has had on these children's health. Our results show a statistically significant relationship between prolonged residence in poor housing and poor health outcomes for some health indicators. The results call for a closer understanding of health issues in housing policy in South Africa.

Purpose: This study used cultural consensus modeling to elucidate culturally relevant factors associated with dual protection use (strategies to prevent both pregnancy and sexually transmitted infection [STI]/HIV) among South African adolescent girls aged 14-17 years., Methods: In Phase 1, participants (N = 50) completed a free-listing survey assessing pregnancy and STI/HIV methods used by peers. In Phase 2, participants (N = 100) completed a rating survey to examine perceived peer acceptability of Phase 1 pregnancy and STI/HIV prevention methods. In Phase 3, qualitative individual interviews (N = 25) gathered in-depth information regarding the cultural acceptability of pregnancy and STI/HIV prevention strategies. In Phase 4, participants (N = 300) completed the Phase 2 rating survey for individual beliefs regarding the acceptability of pregnancy and STI/HIV prevention methods., Results: In Phase 1, 41 pregnancy and 29 STI/HIV prevention strategies, along with 16 factors influencing pregnancy prevention method acceptability were endorsed; male condoms were the most commonly endorsed pregnancy and STI/HIV prevention method. In Phase 2, using cultural consensus analysis, participants were consistent in the perceived acceptability of pregnancy and STI/HIV prevention methods (73.4% variance accounted for in single cultural model). In Phase 3, qualitative findings provided in-depth information regarding factors influencing commonly used pregnancy (e.g., injectable contraception) and STI/HIV (e.g., condoms) prevention methods. In Phase 4, a single cultural model was identified (56.3% variance accounted for), with similar acceptability ratings as Phase 2., Conclusions: A singular cultural model of pregnancy and STI/HIV prevention method acceptability was observed, with little awareness of dual protection. The findings highlight cultural factors for future culturally tailored dual protection interventions for South African adolescent girls., (Copyright © 2020 Society for Adolescent Health and Medicine. Published by Elsevier Inc. All rights reserved.)

The quality of seeds in gene banks gradually deteriorates during long-term storage, which is probably, at least in part, a result of the progressive development of oxidative stress. Here, we report a greenhouse study that was carried out to test whether a novel approach of seed invigoration using priming with cathodic water (cathodic portion of an electrolysed calcium magnesium solution) could improve seedling emergence and growth in two deteriorated crop seeds. Fresh seeds of Pisum sativum and Cucurbita pepo were subjected to controlled deterioration to 50% viability at 14% seed moisture content (fresh weight basis), 40 °C and 100% relative humidity. The deteriorated seeds were thereafter primed with cathodic water, calcium magnesium solution and deionized water. In addition, to study the mechanism of the impacts of invigoration, the effects of such priming on the lipid peroxidation products malondialdehyde (MDA) and 4-hydroxynonenal (4-HNE) and on the reactive oxygen species (ROS) scavenging enzymes superoxide dismutase and catalase were also determined in the fresh and deteriorated seeds. All priming treatments improved seed emergence parameters, subsequent seedling photosynthesis and growth relative to the unprimed seeds. In general, cathodic water was most effective at invigorating deteriorated seeds. Analysis of the lipid peroxidation products and antioxidant enzyme activities in invigorated seeds provided support for the hypothesis that the effectiveness of cathodic water in invigoration of debilitated orthodox seeds in general and of pea and pumpkin seeds in particular derive from its ability to act as an antioxidant.

Background: Cultural consensus modelling (CCM) is an approach whereby individuals define the boundaries regarding a set of knowledge or behaviours shared by a group within a culture using an ethnographic approach., Objectives: To provide an overview of CCM methods and the application of CCM to examine South African adolescent girls' contraceptive and HIV prevention practices., Methods: In phase 1 of a CCM approach, individuals respond to questions about their culture rather than their individual behaviours, allowing individuals to draw upon a shared cultural knowledge. Utilising these identified group beliefs, phase 2 asks individuals to rate the extent to which factors identified in phase 1 are valued. Phase 3 utilises qualitative interviews with key informants from phase 2 to gather in-depth information regarding the identified determinants of the health behaviour. Lastly, phase 4 of this approach conducts a quantitative survey to determine the extent to which cultural consensus model types are associated with differences in actual behaviours., Results: CCM data analytic approaches are described. Frequencies and descriptive statistics for the free listing are conducted. For phase 2, cultural consensus analysis is conducted to examine whether one or several consensus models exist and competence scores are calculated. Standard qualitative analysis approaches are utilised for phase 3. Phase 4 employs regression to examine the association between cultural models and an outcome of interest., Conclusion: CCM provides a novel, culturally sensitive understanding of reproductive health practices among South African adolescent girls; CCM also has broad applicability to other adolescent health research domains., Competing Interests: None., (© 2018 South African Journal of Child Health.)

Introduction: Streptococcus pneumoniae is a leading cause of severe bacterial infections globally. A full understanding of the impact of pneumococcal conjugate vaccine (PCV) on pneumococcal disease burden, following its introduction in 2009 in South Africa, can support national policy on PCV use and assist with policy decisions elsewhere., Methods: We developed a model to estimate the national burden of severe pneumococcal disease, i.e. disease requiring hospitalisation, pre- (2005-2008) and post-PCV introduction (2012-2013) in children aged 0-59 months in South Africa. We estimated case numbers for invasive pneumococcal disease using data from the national laboratory-based surveillance, adjusted for specimen-taking practices. We estimated non-bacteraemic pneumococcal pneumonia case numbers using vaccine probe study data. To estimate pneumococcal deaths, we applied observed case fatality ratios to estimated case numbers. Estimates were stratified by HIV status to account for the impact of PCV and HIV-related interventions. We assessed how different assumptions affected estimates using a sensitivity analysis. Bootstrapping created confidence intervals., Results: In the pre-vaccine era, a total of approximately 107,600 (95% confidence interval [CI] 83,000-140,000) cases of severe hospitalised pneumococcal disease were estimated to have occurred annually. Following PCV introduction and the improvement in HIV interventions, 41,800 (95% CI 28,000-50,000) severe pneumococcal disease cases were estimated in 2012-2013, a rate reduction of 1,277 cases per 100,000 child-years. Approximately 5000 (95% CI 3000-6000) pneumococcal-related annual deaths were estimated in the pre-vaccine period and 1,900 (95% CI 1000-2500) in 2012-2013, a mortality rate difference of 61 per 100,000 child-years., Conclusions: While a large number of hospitalisations and deaths due to pneumococcal disease still occur among children 0-59 months in South Africa, we found a large reduction in this estimate that is temporally associated with PCV introduction. In HIV-infected individuals the scale-up of other interventions, such as improvements in HIV care, may have also contributed to the declines in pneumococcal burden.

The genetics of tick infestation in sheep need study, as host resistance often forms part of integrated pest control programs. Repeated udder health scores, site-specific tick count, mating weight and reproduction records (N=879-1204) were recorded annually from 2010 to 2015 on ewes of the indigenous Namaqua Afrikaner (NA) fat-tailed breed, as well as the commercial Dorper and SA Mutton Merino (SAMM) breeds. Udders were scored subjectively on a 1-5 scale (1 - udder intact and 5 - udder damaged severely) and ticks were counted on three locations. The body sites counted were the head and thoracic limb (HTLTC), udder-pelvic limb (UPLTC) and perineum-breech-tail (PBTTC). These counts were also totaled for a total tick count (TTC). Reproduction traits were number of lambs weaned per ewe lambed and total weight of lamb weaned per ewe lambed. Udder health scores of NA ewes were lower than those of Dorpers, which in turn had lower scores than SAMM ewes. NA ewes had lower values for HTLTC, UPLTC and TTC than the commercial breeds, but higher values for PBTTC than Dorpers. Heritability estimates amounted to 0.26±0.04 for HTLTC, 0.53±0.04 for UPLTC, 0.07±0.06 for PBTTC, 0.44±0.06 for TTC and 0.61±0.03 for udder health score. Animal permanent environment also affected PBTTC (0.14±0.07). Significant genetic correlations were found between the HTLTC and UPLTC (0.47±0.10), UPLTC and udder health score (0.52±0.07), HTLTC and UPLTC (0.24±0.11) as well as UPLTC and PBTTC (-0.44±0.11). Heavier ewes had higher UPLTC (0.38±0.09), TTC (0.33±0.09) and impaired udder health (0.21±0.08). Udder health scores and tick counts at all sites were not related to reproduction traits. The indigenous NA breed outperformed the commercial breeds with lower values for HTLTC, UPLTC, TTC and a better udder health score. Mechanisms contributing to the better performance of the NA breed under pastoral conditions and the scope for selection for tick tolerance within breeds should be studied further., (Copyright © 2016 Elsevier B.V. All rights reserved.)

Background: A growing body of observational evidence suggests that nutritional and physical activity interventions are associated with beneficial outcomes for men with prostate cancer, including brisk walking, lycopene intake, increased fruit and vegetable intake and reduced dairy consumption. However, randomised controlled trial data are limited. The 'Prostate Cancer: Evidence of Exercise and Nutrition Trial' investigates the feasibility of recruiting and randomising men diagnosed with localised prostate cancer and eligible for radical prostatectomy to interventions that modify nutrition and physical activity. The primary outcomes are randomisation rates and adherence to the interventions at 6 months following randomisation. The secondary outcomes are intervention tolerability, trial retention, change in prostate specific antigen level, change in diet, change in general physical activity levels, insulin-like growth factor levels, and a range of related outcomes, including quality of life measures., Methods/design: The trial is factorial, randomising men to both a physical activity (brisk walking or control) and nutritional (lycopene supplementation or increased fruit and vegetables with reduced dairy consumption or control) intervention. The trial has two phases: men are enrolled into a cohort study prior to radical prostatectomy, and then consented after radical prostatectomy into a randomised controlled trial. Data are collected at four time points (cohort baseline, true trial baseline and 3 and 6 months post-randomisation)., Discussion: The Prostate Cancer: Evidence of Exercise and Nutrition Trial aims to determine whether men with localised prostate cancer who are scheduled for radical prostatectomy can be recruited into a cohort and subsequently randomised to a 6-month nutrition and physical activity intervention trial. If successful, this feasibility trial will inform a larger trial to investigate whether this population will gain clinical benefit from long-term nutritional and physical activity interventions post-surgery. Prostate Cancer: Evidence of Exercise and Nutrition Trial (PrEvENT) is registered on the ISRCTN registry, ref number ISRCTN99048944. Date of registration 17 November 2014.

Desert ungulates live in adverse ecosystems that are particularly sensitive to degradation and global climate change. Here, we asked how two ungulate species with contrasting feeding habits, grazing gemsbok (Oryx g. gazella) and browsing springbok (Antidorcas marsupialis), respond to an increase in food availability during a pronounced rain period. We used a stable isotope approach to delineate the feeding habits of these two ungulates in the arid Kunene Region of Namibia. Our nineteen months field investigation included two time periods of drought when food availability for ungulates was lowest and an intermediate period with extreme, unusual rainfalls. We documented thirteen isotopically distinct food sources in the isotopic space of the study area. Our results indicated a relatively high dietary plasticity of gemsbok, which fed on a mixture of plants, including more than 30% of C3 plants during drought periods, but almost exclusively on C4 and CAM plant types when food was plentiful. During drought periods, the inferred gemsbok diets also consisted of up to 25% of Euphorbia damarana; an endemic CAM plant that is rich in toxic secondary plant compounds. In contrast, springbok were generalists, feeding on a higher proportion of C3 than C4/CAM plants, irrespective of environmental conditions. Our results illustrate two dietary strategies in gemsbok and springbok which enable them to survive and coexist in the hostile Kunene arid ecosystem.

Data were obtained from a population consisting of 160 Merino ewes, as well as 64 male and 75 female progeny of these ewes at the 2-tooth age. The age and sex groups were maintained in separate flocks. The population has been divergently selected from the same base since 1986, either for (high or H line) or against (low or L line) maternal multiple rearing ability. All animals were inspected for sheep lice (Bovicola ovis) during September/October 2002 after a wool growth period of at least 4 months. When expressed relative to mean L-line performance, the advantage in lambs weaned per ewe during the lambing season amounted to approximately 110% in the H line (1.01 vs 0.48; P < 0.01). The proportion of animals on which 1 or more lice were observed were markedly lower in 2-tooth replacement ewes than in replacement rams and mature breeding ewes (0.053 vs 0.625 and 0.531, respectively; P < 0.01). One or more lice were observed on a lower proportion of H-line ewes than on those of the L line (0.413 vs 0.571, respectively; P < 0.10), while a similar tendency was observed in 2-tooth ewe hoggets (0.033 vs 0.143, respectively; P = 0.16). When the mean number of lice on individuals on which 1 or more lice were observed was compared between lines, the average number of lice observed on H-line young rams was lower than in the L line (4.36 +/- 0.85 vs 9.71 +/- 1.84 lice, respectively; P < 0.01). A similar tendency was observed in mature breeding ewes (2.15 +/- 0.38 vs 3.22 +/- 0.42 lice, respectively; P < 0.20). The more highly reproductive H-line ewes were not more susceptible to infestation with B. ovis than ewes of the L line. In fact, available evidence suggest that H-line animals could be more tolerant of B. ovis than those of the L line.