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10. LOXL1 gene polymorphism candidates for exfoliation glaucoma are also associated with a risk for primary open-angle glaucoma in a Caucasian population from central Russia

Author

Eliseeva, N., Ponomarenko, I., Evgeny Reshetnikov, Dvornyk, V., and Churnosov, M.

Subjects
eye diseases, Research Article
Abstract

Purpose This study was aimed to replicate the previously reported associations of the three LOXL1 gene polymorphisms with exfoliation glaucoma (XFG) and to analyze these genetic variants for their possible contribution to primary open-angle glaucoma (POAG) in Caucasians from central Russia. Methods In total, 932 participants were recruited for the study, including 328 patients with XFG, 208 patients with POAG, and 396 controls. The participants were of Russian ethnicity (self-reported) and born in Central Russia. They were genotyped at three single nucleotide polymorphisms (SNPs) of the LOXL1 gene (rs2165241, rs4886776, and rs893818). The association was analyzed using logistic regression. Results Allele C of rs2165241 was associated with a decreased risk of XFG (odds ratio [OR] =0.27–0.45, pperm ≤5*10−6) and POAG (OR=0.35–0.47, рperm≤0.001), and allele A of rs4886776 and rs893818 were associated with a lower risk of XFG (OR=0.53–0.57, рperm≤0.001). Haplotype TGG of loci rs2165241-rs4886776-rs893818 was associated with an elevated risk of XFG (OR=2.23, рperm=0.001) and POAG (OR=2.01, рperm=0.001), haplotype CGG was also associated with a decreased risk of XFG (OR=0.45, рperm=0.001) and POAG (OR=0.35, рperm=0.001). Haplotype CAA was associated with a decreased risk of XFG only (OR=0.50, рperm=0.001). Conclusions Polymorphisms rs2165241, rs4886776, and rs893818 of the LOXL1 gene showed association with XFG and POAG in a Caucasian sample from central Russia.

Published
2021

15. Characterizing the genetic history of admixture across inner Eurasia

Author

Jeong, C., Balanovsky, O., Lukianova, E., Kahbatkyzy, N., Flegontov, P., Zaporozhchenko, V., Immel, A., Wang, C., Ixan, O., Khussainova, E., Bekmanov, B., Zaibert, V., Lavryashina, M., Pocheshkhova, E., Yusupov, Y., Agdzhoyan, A., Sergey, K., Bukin, A., Nymadawa, P., Churnosov, M., Skhalyakho, R., Daragan, D., Bogunov, Y., Bogunova, A., Shtrunov, A., Dubova, N., Zhabagin, M., Yepiskoposyan, L., Churakov, V., Pislegin, N., Damba, L., Saroyants, L., Dibirova, K., Artamentova, L., Utevska, O., Idrisov, E., Kamenshchikova, E., Evseeva, I., Metspalu, M., Robbeets, M., Djansugurova, L., Balanovska, E., Schiffels, S., Haak, W., Reich, D., and Krause, J.

Abstract

The indigenous populations of inner Eurasia, a huge geographic region covering the central Eurasian steppe and the northern Eurasian taiga and tundra, harbor tremendous diversity in their genes, cultures and languages. In this study, we report novel genome-wide data for 763 individuals from Armenia, Georgia, Kazakhstan, Moldova, Mongolia, Russia, Tajikistan, Ukraine, and Uzbekistan. We furthermore report genome-wide data of two Eneolithic individuals (~5,400 years before present) associated with the Botai culture in northern Kazakhstan. We find that inner Eurasian populations are structured into three distinct admixture clines stretching between various western and eastern Eurasian ancestries. This genetic separation is well mirrored by geography. The ancient Botai genomes suggest yet another layer of admixture in inner Eurasia that involves Mesolithic hunter-gatherers in Europe, the Upper Paleolithic southern Siberians and East Asians. Admixture modeling of ancient and modern populations suggests an overwriting of this ancient structure in the Altai-Sayan region by migrations of western steppe herders, but partial retaining of this ancient North Eurasian-related cline further to the North. Finally, the genetic structure of Caucasus populations highlights a role of the Caucasus Mountains as a barrier to gene flow and suggests a post-Neolithic gene flow into North Caucasus populations from the steppe.

Published
2018

19. Ancient human genomes suggest three ancestral populations for present-day Europeans

Author

Lazaridis, I, Patterson, N, Mittnik, A, Renaud, G, Mallick, S, Kirsanow, K, Sudmant, Ph, Schraiber, Jg, Castellano, S, Lipson, M, Berger, B, Economou, C, Bollongino, R, Fu, Q, Bos, Ki, Nordenfelt, S, Li, H, De Filippo, C, Prüfer, K, Sawyer, S, Posth, C, Haak, W, Hallgren, F, Fornander, E, Rohland, N, Delsate, D, Francken, M, Guinet, Jm, Wahl, J, Ayodo, G, Babiker, Ha, Bailliet, G, Balanovska, E, Balanovsky, O, Bedoya, G, Ben Ami, H, Bene, J, Berrada, F, Bravi, Cm, Brisighelli, Francesca, Busby, Gb, Cali, F, Churnosov, M, Cole, De, Corach, D, Damba, L, Van Driem, G, Dryomov, S, Fedorova, Sa, Gallego Romero, I, Gubina, M, Hammer, M, Henn, Bm, Hervig, T, Hodoglugil, U, Jha, Ar, Karachanak Yankova, S, Khusainova, R, Khusnutdinova, E, Kittles, R, Kivisild, T, Kučinskas, V, Kushniarevich, A, Laredj, L, Litvinov, S, Loukidis, T, Mahley, Rw, Melegh, B, Metspalu, E, Molina, J, Mountain, J, Näkkäläjärvi, K, Nesheva, D, Nyambo, T, Osipova, L, Platonov, F, Posukh, O, Romano, V, Rothhammer, F, Rudan, I, Ruizbakiev, R, Sahakyan, H, Sajantila, A, Salas, A, Starikovskaya, Eb, Tarekegn, A, Toncheva, D, Turdikulova, S, Utevska, O, Vasquez, R, Villena, M, Voevoda, M, Winkler, Ca, Yepiskoposyan, L, Zalloua, P, Zemunik, T, Cooper, A, Capelli, C, Ruiz Linares, A, Tishkoff, Sa Et Al, Brisighelli, Francesca (ORCID:0000-0001-5469-4413), Lazaridis, I, Patterson, N, Mittnik, A, Renaud, G, Mallick, S, Kirsanow, K, Sudmant, Ph, Schraiber, Jg, Castellano, S, Lipson, M, Berger, B, Economou, C, Bollongino, R, Fu, Q, Bos, Ki, Nordenfelt, S, Li, H, De Filippo, C, Prüfer, K, Sawyer, S, Posth, C, Haak, W, Hallgren, F, Fornander, E, Rohland, N, Delsate, D, Francken, M, Guinet, Jm, Wahl, J, Ayodo, G, Babiker, Ha, Bailliet, G, Balanovska, E, Balanovsky, O, Bedoya, G, Ben Ami, H, Bene, J, Berrada, F, Bravi, Cm, Brisighelli, Francesca, Busby, Gb, Cali, F, Churnosov, M, Cole, De, Corach, D, Damba, L, Van Driem, G, Dryomov, S, Fedorova, Sa, Gallego Romero, I, Gubina, M, Hammer, M, Henn, Bm, Hervig, T, Hodoglugil, U, Jha, Ar, Karachanak Yankova, S, Khusainova, R, Khusnutdinova, E, Kittles, R, Kivisild, T, Kučinskas, V, Kushniarevich, A, Laredj, L, Litvinov, S, Loukidis, T, Mahley, Rw, Melegh, B, Metspalu, E, Molina, J, Mountain, J, Näkkäläjärvi, K, Nesheva, D, Nyambo, T, Osipova, L, Platonov, F, Posukh, O, Romano, V, Rothhammer, F, Rudan, I, Ruizbakiev, R, Sahakyan, H, Sajantila, A, Salas, A, Starikovskaya, Eb, Tarekegn, A, Toncheva, D, Turdikulova, S, Utevska, O, Vasquez, R, Villena, M, Voevoda, M, Winkler, Ca, Yepiskoposyan, L, Zalloua, P, Zemunik, T, Cooper, A, Capelli, C, Ruiz Linares, A, Tishkoff, Sa Et Al, and Brisighelli, Francesca (ORCID:0000-0001-5469-4413)

Abstract

We sequenced the genomes of a ∼7,000-year-old farmer from Germany and eight ∼8,000-year-old hunter-gatherers from Luxembourg and Sweden. We analysed these and other ancient genomes with 2,345 contemporary humans to show that most present-day Europeans derive from at least three highly differentiated populations: west European hunter-gatherers, who contributed ancestry to all Europeans but not to Near Easterners; ancient north Eurasians related to Upper Palaeolithic Siberians, who contributed to both Europeans and Near Easterners; and early European farmers, who were mainly of Near Eastern origin but also harboured west European hunter-gatherer related ancestry. We model these populations' deep relationships and show that early European farmers had ∼44% ancestry from a 'basal Eurasian' population that split before the diversification of other non-African lineages.

Published
2014

20. The study of the role of genetic polymorphisms of cytokines in the hyperplastic uterogenic processes formation

Author

Goryainova, N., Altuhova, O., Krikun, E., Koneva, O., Churnosov, M., Goryainova, N., Altuhova, O., Krikun, E., Koneva, O., and Churnosov, M.

Abstract

The aim of the study was to investigate the role of molecular-genetic markers of cytokines in the formation of hyperplastic processes in uterus, Белгородский государственный университет

21. Epistatic interactions in formation of hysteromyoma

Author

Ponomarenko, V. I., Altuchova, O. B., Kulikovskiy, V. F., Batlutkaya, I. V., Churnosov, M. I., Ponomarenko, V. I., Altuchova, O. B., Kulikovskiy, V. F., Batlutkaya, I. V., and Churnosov, M. I.

Abstract

The article highlights the bioinformatics analysis data of eight polymorphous loci among 569 patients with hysteromyoma and 981 women from the control group

22. Genes of tumor necrosis factors and their receptors and the primary open angle glaucoma in the population of Central Russia

Author

Tikunova, E., Ovtcharova, V., Reshetnikov, E., Polonikov, A., Churnosov, M., Tikunova, E., Ovtcharova, V., Reshetnikov, E., Polonikov, A., and Churnosov, M.

Abstract

To examine the association of genetic polymorphisms (-308)G/A TNFα, (+250)A/G Ltα, (+36)A/G TNFR1, (+1663) A/G TNFR2 with the development of primary open angle glaucoma (POAG) among people in Central Russia

23. Study of the associations between polymorphic markers rs1800629 TNFα, rs909253 Ltα, rs767455 TNFR1, rs1061624 TNFR2 and the development of type 2 diabetes = Изучение ассоциаций полиморфных маркеров генов факторов некроза опухоли и их рецепторов rs1800629 TNFα, rs909253 Ltα, rs767455 TNFR1, rs1061624 TNFR2 с формированием сахарного диабета 2 типа

Author

Churnosov, M. I., Belousova, O. N., Sirotina, S. S., Churnosov, M. I., Belousova, O. N., and Sirotina, S. S.

Abstract

To study the association between polymorphic genetic markers, tumor necrosis factors and their receptors (rs 1800629 TNFα, rs 909253 Ltα, rs 767455 TNFR1, rs 1061624 TNFR2) and the development of type 2 diabetes (T2D) among the population of the Central Black Earth Region of Russia

24. Correction of retinal ischemia/reperfusion by 3-(1H-benzimidazol-2-il)-1,2,2-trimethyl cyclopentancarbonic acid in experiment

Author

Peresypkina, A. A., Levkova, E. A., Yakushev, V. I., Bunyatyan, N. D., Churnosov, M. I., Peresypkina, A. A., Levkova, E. A., Yakushev, V. I., Bunyatyan, N. D., and Churnosov, M. I.

Abstract

Results of ocular fundus studies revealed the most pronounced protective effects of 3-(1Hbenzimidazol-2-il)-1,2,2-trimethyl cyclopentancarbonic acid in a dose 50 mg/kg on the model of retinal ischemiareperfusion in Wistar rats, which is reflected in the restoration of the optic disc. Correction of retinal ischemiareperfusion by 3-(1H-benzimidazol-2-il)-1,2,2-trimethyl cyclopentancarbonic acid in a dose 50 mg/kg leads to higher values of the coefficient b/a of electroretinography after 72 hours of reperfusion compared to the group with pathology correction by the same drug in a dose 10 mg/kg, which indicates the restoration of the electrophysiological state of the retina

25. The relationship between the - 344С˃T polymorphism of gene encoding aldosterone synthase and the prothrombin time in patients with intracerebral hemorrhage

Author

Stetskaya, T., Polonikov, A., Churnosov, M., Bushueva, O., Stetskaya, T., Polonikov, A., Churnosov, M., and Bushueva, O.

Abstract

Gene encoding aldosterone synthase gene (CYP11B2), has been suggested to contribute to stroke. The present study was designed to investigate whether common functional polymorphism −344C>T (rs179998) of the CYP11B2 gene is associated with ischemic stroke (IS) and intracerebral hemorrhage (ICH) in a Russian population, Belgorod State National Research University

26. Joint effect of glutathione S-transferase genotypes and cigarette smoking on idiopathic male infertility

Author

Yarosh, S. L., Kokhtenko, E. V., Churnosov, M. I., Solodilova, M. A., Polonikov, A. V., Yarosh, S. L., Kokhtenko, E. V., Churnosov, M. I., Solodilova, M. A., and Polonikov, A. V.

Abstract

Inconsistent results of association studies investigated the role of glutathione S-transferase genes in idiopathic male infertility may be explained by ethnical differences in gene-gene and gene-environment interactions. In this study, we investigated a joint contribution of GSTM1, GSTT1 and GSTP1 gene polymorphisms and cigarette smoking to the risk of idiopathic infertility in Russian men, Belgorod State National Research University

27. The gene pool of the Belgorod oblast population : malecot’s isolation-by-distance parameters

Author

Sorokina, I. N., Churnosov, M. I., Sorokina, I. N., and Churnosov, M. I.

Abstract

The mean distance between birthplaces of spouses (у, у '), the proportion of medium migrations (k), and the effective migration pressure (Me) have considerably increased, and the linear systematic pressure coefficient (b) has decreased in the human population of the Central Chernozem region during the past 50 years. However, the local inbreeding level (a), which is determined by both an increase in the migration intensity and a decrease in the effective population size (Ne), has remained practically unchanged

28. Epistatic interactions in formation of hysteromyoma

Author

Ponomarenko, V. I., Altuchova, O. B., Kulikovskiy, V. F., Batlutkaya, I. V., Churnosov, M. I., Ponomarenko, V. I., Altuchova, O. B., Kulikovskiy, V. F., Batlutkaya, I. V., and Churnosov, M. I.

Abstract

The article highlights the bioinformatics analysis data of eight polymorphous loci among 569 patients with hysteromyoma and 981 women from the control group

30. The genetic history of admixture across inner Eurasia

Author

Jeong, C., Balanovsky, O., Lukianova, E., Kahbatkyzy, N., Churnosov, M., Jeong, C., Balanovsky, O., Lukianova, E., Kahbatkyzy, N., and Churnosov, M.

Abstract

Eurasian taiga and tundra - harbour tremendous diversity in their genes, cultures and languages. In this study, we report novel genome-wide data for 763 individuals from Armenia, Georgia, Kazakhstan, Moldova, Mongolia, Russia, Tajikistan, Ukraine and Uzbekistan. We furthermore report additional damage-reduced genome-wide data of two previously published individuals from the Eneolithic Botai culture in Kazakhstan (~5,400 bp)

31. The VNTR polymorphism of the endothelial nitric oxide synthase gene and blood pressure in women at the end of pregnancy

Author

Reshetnikov, E., Ponomarenko, I., Golovchenko, O., Sorokina, I., Batlutskaya, I., Yakunchenko, T., Churnosov, M., Reshetnikov, E., Ponomarenko, I., Golovchenko, O., Sorokina, I., Batlutskaya, I., Yakunchenko, T., and Churnosov, M.

Abstract

Examine the association of the 4a/4b polymorphism of endothelial nitric oxide synthase (eNOS) with blood pressure in women at late pregnancy

32. Association of C3435T (rs1045642) polymorphism of the MDR1 gene with the increased risk of colorectal cancer in russian females from Central Russia

Author

Moskalev, A. S., Barysheva, E. M., Soldatov, V. O., Frolova, O. G., Churnosov, M. I., Moskalev, A. S., Barysheva, E. M., Soldatov, V. O., Frolova, O. G., and Churnosov, M. I.

Abstract

The objective of this study was to examine associations of single nucleotide polymorphisms, rs1045642 within the MDR1 gene and rs1799930 within the NAT2 gene, with the risk of colorectal cancer (CRC) in the population of Central Russia

33. Matrix metalloproteinases as target genes for gene regulatory networks driving molecular and cellular pathways related to a multistep pathogenesis of cerebrovascular disease

Author

Polonikov, A., Rymarova, L., Klyosova, E., Volkova, A., Churnosov, M., Polonikov, A., Rymarova, L., Klyosova, E., Volkova, A., and Churnosov, M.

Abstract

The present study investigated a joint contribution of matrix metalloproteinases (MMPs) genes to ischemic stroke (IS) development and analyzed interactions between MMP genes and genome‐wide associated loci for IS. A total of 1288 unrelated Russians (600 IS patients and 688 healthy individuals) from Central Russia were recruited for the study

34. The association of rs12444979 and rs2241423 genotype combination with the risk of uterine hyperplastic processes

Author

Polonikov, A., Krivoshei, I., Churnosov, M., Polonikov, A., Krivoshei, I., and Churnosov, M.

Abstract

A lot of women of fertile and predecidual age have hyperplastic processes of endometrium having a risk of malignization in 10-50% of cases. The present study investigated an association between rs12444979 and rs2241423 polymorphisms and risk of uterine hyperplastic processes in Russian women

36. Association of polymorphic markers rs243865 and rs3025058 with the development of arterial hypertension

Author

Polonikov, A., Moskalenko, M., Churnosov, M., Zhernakova, N., Milanova, S., Polonikov, A., Moskalenko, M., Churnosov, M., Zhernakova, N., and Milanova, S.

Abstract

Association of polymorphic markers rs243865 and rs3025058 with the development of arterial hypertension Essential hypertension is a multifactorial polygenic disease with a highest incidence in the world. The purpose of the study was to assess the relationship between gene polymorphisms MMP2-1586S>T (rs243865) and -1612 5A/6A MMP3 (rs3025058) with the development of arterial hypertension in population of the Central Chernozem region of Russia

37. Molecular-genetic factors of genital endometriosis

Author

Ponomarenko, I. V., Altuchova, O. B., Golovchenko, O. V., Sorokina, I. N., Polonikov, A. V., Bushueva, O. Yu., Churnosov, M. I., Ponomarenko, I. V., Altuchova, O. B., Golovchenko, O. V., Sorokina, I. N., Polonikov, A. V., Bushueva, O. Yu., and Churnosov, M. I.

Abstract

Article concerns data of the comparative analysis of polymorphic options of genes at patients with genital endometriosis and women in control group

38. Pharmacogenetic study of lipid-lowering therapy with rosuvastatin in coronary artery disease patients

Author

Polonikov, A., Zvyagina, M., Krivoshei, I., Sirotina, S., Churnosov, M., Polonikov, A., Zvyagina, M., Krivoshei, I., Sirotina, S., and Churnosov, M.

Abstract

Polymorphic genes involved in the regulation of lipid metabolism may be responsible for interindividual differences in efficiency of hypolipidaemic therapy. In the present prospective and randomised study, we investigated the efficacy of rosuvastatin (10 mg/day) in lipid-lowering therapy in 62 patients with coronary artery disease (CAD) possessing different genotypes of lipoprotein lipase (LPL) gene

39. The contribution of MTHFR C677T polymorphism to peripheral artery disease in diabetic patients

Author

Polonikov, A., Sirotina, S., Krivoshei, I., Churnosov, M., Solodilova, M., Polonikov, A., Sirotina, S., Krivoshei, I., Churnosov, M., and Solodilova, M.

Abstract

The aim of this study was to investigate the association between functional polymorphism C677T (rs1801133) of methylenetetrahydrofolate reductase (MTHFR) gene for and risk of peripheral artery disease in diabetes patients

40. Genes Involved in Vascular Homeostasis are responsible for alterations in erythrocyte membrane proteins in patients with essential hypertension

Author

Polonikov, A., Ushachev, D., Krivoshei, I., Sirotina, S., Churnosov, M., Polonikov, A., Ushachev, D., Krivoshei, I., Sirotina, S., and Churnosov, M.

Abstract

Alterations in structural and functional properties of the cell membrane may represent diseaseassociated intermediate phenotypes reflecting the mechanisms of essential hypertension. The study was designed to assess the effects of polymorphisms in genes associated with EH on the variation of erythrocyte membrane proteins in hypertensive patients

42. Genetic association between the CYBA 640A>G polymorphism and the risk of uterine myoma

Author

Polonikov, A., Kudryavtseva, O., Dolzhenkova, E., Churnosov, M., Bushueva, O., Polonikov, A., Kudryavtseva, O., Dolzhenkova, E., Churnosov, M., and Bushueva, O.

Abstract

The aim of this study was to investigate the association between functional polymorphism 640A>G (rs1049255) of the CYBA (cytochrome b-245, alpha polypeptide of NADPH oxidase) gene and the risk of uterine myoma

43. Bioinformatic analysis of candidate genes for endometrial hyperplasia

Author

Ponomarenko, V. I., Sorokina, I. N., Rudyh, N. A., Polonikov, A. V., Churnosov, M. I., Ponomarenko, V. I., Sorokina, I. N., Rudyh, N. A., Polonikov, A. V., and Churnosov, M. I.

Abstract

Article concerns data of the bio-informational analysis of polymorphic options of genes at patients with endometrial hyperplasia and women in control group

44. Candidate genes and clinical-laboratory indices in pregnant women depending on the development of preeclampsia

Author

Reshetnikov, E. A., Kulikovskii, V. F., Batlutskaya, I. V., Iakunchenko, T. I., Churnosov, M. I., Reshetnikov, E. A., Kulikovskii, V. F., Batlutskaya, I. V., Iakunchenko, T. I., and Churnosov, M. I.

Abstract

The relationship between polymorphic variants of folate metabolism genes with clinical (blood pressure level before and at the end of pregnancy) and clinical and laboratory indicators (proteinuria, fibrinogen, total protein, urea and creatinine in the blood, activated partial thromboplastin time, thrombin time) were studied in pregnant women with preeclampsia

45. Clinical and genetic study of chronic kidney disease

Author

Nekipelova, E. V., Novakova, O. N., Kulikovskij, V. F., Zhernakova, N. I., Churnosov, M. I., Nekipelova, E. V., Novakova, O. N., Kulikovskij, V. F., Zhernakova, N. I., and Churnosov, M. I.

Abstract

This paper presents the results of the study of the interrelationships of polymorphic loci of chemokines (rs1719153, rs4512021, rs2107538, rs2857657, rs1801157) with features of humoral immunity in patients with chronic glomerulonephritis

46. The level of fibrinogen and gene polymorphism in pregnant women with placental insufficiency

Author

Reshetnikov, E. A., Orlova, L. S., Batlutskaya, I. V., Rudyh, N. A., Churnosov, M. I., Reshetnikov, E. A., Orlova, L. S., Batlutskaya, I. V., Rudyh, N. A., and Churnosov, M. I.

Abstract

To study the association of genetic polymorphisms of coagulation factors with clinical and laboratory indicators in pregnant women with placental insufficiency with fetal growth retardation

47. Genetic factors of hysteromyoma

Author

Krivoshei, I. V., Altuchova, O. B., Golovchenko, O. V., Orlova, V. S., Churnosov, M. I., Krivoshei, I. V., Altuchova, O. B., Golovchenko, O. V., Orlova, V. S., and Churnosov, M. I.

Abstract

Study concerns data of the bioinformative analysis of polymorphic options of genes at patients with hysteromyoma and women in control group. There were determined combinations genetic variations CC F13A1 with A FTO (OR=1.55), C F13A1 with CC CNVs (OR=1.58), G FTO with A KDM3B and C CNVs (OR=1.38) with hysteromyoma developing in the women of Russia Central Region

48. Associations of insertion-deletion polymorphism of angiotensin-converting enzyme with the risk of preeclampsia development among pregnant women in Central Russia

Author

Reshetnikov, E. A., Yakunchenko, T. I., Aristova, I. K., Polonikov, A. V., Churnosov, M. I., Reshetnikov, E. A., Yakunchenko, T. I., Aristova, I. K., Polonikov, A. V., and Churnosov, M. I.

Abstract

The associations of the insertion-deletion angiotensin-converting enzyme (I/D ACE) genetic polymorphism with the risk of preeclampsia development were studied

49. The relationship of molecular-genetic markers of chemokines with clinical manifestations of chronic kidney disease

Author

Nekipelova, E. V., Novakova, O. N., Yakunchenko, T. I., Churnosov, M. I., Zhernakova, N. I., Nekipelova, E. V., Novakova, O. N., Yakunchenko, T. I., Churnosov, M. I., and Zhernakova, N. I.

Abstract

The article presents the results of studying the relationship of polymorphic variants of chemokine genes (1931A/T CCL4, A/G CXCL11 (rs4512021), - 403A/G CCL5, C/G CCL2 (rs2857657), - 801G/A CXCL12) with the features of clinical manifestations of chronic glomerulonephritis

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