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14. Hydrocephalus--what's new? (Leading article)

Author

Chumas, P, Tyagi, A, and Livingston, J

Subjects
Care and treatment, Physiological aspects, Cerebrospinal fluid shunts -- Physiological aspects, Cerebrospinal fluid -- Physiological aspects, Hydrocephalus -- Care and treatment
Abstract

'Not a lot' may be the general impression, but then it is easy to forget that, until the advent of shunts (almost 50 years ago), hydrocephalus was usually fatal. It [...]

Published
2001

16. Neuropsychological outcomes following paediatric temporal lobe surgery for epilepsies: Evidence from a systematic review

Author

Flint, AE, Waterman, M, Bowmer, G, Vadlamani, G, Chumas, P, and Morrall, MCHJ

Abstract

Objective: The systematic review aimed to assess the neuropsychological outcomes of temporal lobe resections for epilepsy in children. Additional objectives included determining whether earlier age at surgery leads to better neuropsychological outcomes; the relationships between and predictors of these outcomes. Methods: Using advanced search terms, a systematic review of electronic databases was conducted, comprising MEDLINE, Embase, PsycINFO, Global Health, Web of Science and CINAHL. Included studies reported on outcome following neurosurgical treatment for epilepsy. Specifically, studies were included if they reported neuropsychological outcomes and were concerned only with temporal lobe resection. Results: 73 studies met inclusion criteria. For reported neuropsychological outcomes, the majority of participants remained stable after surgery; some declined and some improved. There was some evidence for increased material-specific memory deficits after temporal lobe surgery based on resection side, and more positive cognitive outcome for those with lower pre-surgical ability level. Significance: Retrieved evidence highlights the need for improvements to quality of methodology and reporting. Appropriately designed prospective multicentre trials should be conducted with adequate follow-up for long-term outcomes to be measured. Core outcome measures should be agreed between centres. This would permit higher quality evidence so that clinicians, young people and their families may make better informed decisions about whether or not to proceed with surgery and likely post-operative profile.

Published
2017

17. Minor complications in craniofacial surgery are more common than previously thought

Author

Shastin, D, Peacock, S, Goodden, J, Russell, J, Liddington, M, and Chumas, P

Subjects
ddc: 610, 610 Medical sciences, Medicine
Abstract

Introduction: Tabulation of complications is a common way of evaluating craniosynostosis practice. Due to the lack of standartisation in the literature, objective comparison is often difficult. The authors propose a new classification that builds on prospective data collection and is designed to systematically[for full text, please go to the a.m. URL], 68. Jahrestagung der Deutschen Gesellschaft für Neurochirurgie (DGNC), 7. Joint Meeting mit der Society of British Neurological Surgeons (SBNS)

Published
2017
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24. Effect of hydrophilic coating on microorganism colonization in silicone tubing

Author

Çagavi F., Akalan N., Çelik H., Gür D., Güçiz B., Haines S., Chumas P., and Zonguldak Bülent Ecevit Üniversitesi

Subjects
Male, medicine.medical_specialty, Colony Count, Microbial, Silicones, In Vitro Techniques, Rats, Sprague-Dawley, chemistry.chemical_compound, Silicone, Bacterial colonization, Coated Materials, Biocompatible, Vancomycin, Staphylococcus epidermidis, medicine, Animals, Humans, Colonization, Dimethylpolysiloxane (silicone), biology, business.industry, Significant difference, technology, industry, and agriculture, Povidone, Polyvinylpyrrolidone, biology.organism_classification, Silicone tubing, Cerebrospinal Fluid Shunts, Rats, Surgery, Hydrophilic coating, chemistry, Biofilms, Microscopy, Electron, Scanning, Silicone Elastomers, Neurology (clinical), business, Hydrocephalus, medicine.drug, Biomedical engineering
Abstract

Background. Shunt infections are one of the major causes of mortality and morbidity of patients with hydrocephalus. The aim of this research is to compare the bacterial colonization characteristics of a regular silicone elastomer shunt material coated with polyvinylpyrrolidone and dimethylpolysiloxane (silicone). Method. Regular coated shunt materials were compared by in-vivo and in-vitro methods. In the in-vitro experiment, silicone and coated material immersed and not immersed in vancomycin solution was treated with a certain concentration of Staphylococcus epidermidis. In the in-vivo study, silicone and coated material specimens were treated with Staphylococcus epidermidis and they were stereotactically placed in the lateral ventricles of the rats. One week after the inoculation, shunt pieces were removed and the colonies were counted by using a scanning electron microscope. Findings. There was a statistically significant difference of colonization in the in-vitro groups in coated material vs. silicone, coated material vs. vancomycin treated silicone, vancomycin treated coated material vs. silicone, vancomycin treated coated material vs. vancomycin treated silicone. There was no statistically significant difference for colonization in in-vitro groups of coated material and vancomycin treated coated material. With in-vivo experiments we can say that, coated material catheters are superior than the silicone catheters in respect to colonization but after the bacterial colonization has occurred, the amount of colonization did not differ. Interpretation. Coated material catheters are superior to silicone catheters and they prevent bacterial colonization in some respect.

Published
2004
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28. Pre-surgical mapping of eloquent cortex for paediatric epilepsy surgery candidates: Evidence from a review of advanced functional neuroimaging.

Author

Collinge, Sarah, Prendergast, Garreth, Mayers, Steven T., Marshall, David, Siddell, Poppy, Neilly, Elizabeth, Ferrie, Colin D., Vadlamani, Gayatri, Macmullen-Price, Jeremy, Warren, Daniel J., Zaman, Arshad, Chumas, Paul, Goodden, John, and Morrall, Matthew C.H.J.

Abstract

Purpose: A review of all published evidence for mapping eloquent (motor, language and memory) cortex using advanced functional neuroimaging (functional magnetic resonance imaging [fMRI] and magnetoencephalography [MEG]) for paediatric epilepsy surgery candidates has not been conducted previously. Research in this area has predominantly been in adult populations and applicability of these techniques to paediatric populations is less established.Methods: A review was performed using an advanced systematic search and retrieval of all published papers examining the use of functional neuroimaging for paediatric epilepsy surgery candidates.Results: Of the 2724 papers retrieved, 34 met the inclusion criteria. Total paediatric participants identified were 353 with an age range of 5 months-19 years. Sample sizes and comparisons with alternative investigations to validate techniques are small and variable paradigms are used. Sensitivity 0.72 (95% CI 0.52-0.86) and specificity 0.60 (95% CI 0.35-0.92) values with a Positive Predictive Value of 74% (95% CI 61-87) and a Negative Predictive Value of 65% (95% CI 52-78) for fMRI language lateralisation with validation, were obtained. Retrieved studies indicate evidence that both fMRI and MEG are able to provide information lateralising and localising motor and language functions.Conclusions: A striking finding of the review is the paucity of studies (n=34) focusing on the paediatric epilepsy surgery population. For children, it remains unclear which language and memory paradigms produce optimal activation and how these should be quantified in a statistically robust manner. Consensus needs to be achieved for statistical analyses and the uniformity and yield of language, motor and memory paradigms. Larger scale studies are required to produce patient series data which clinicians may refer to interpret results objectively. If functional imaging techniques are to be the viable alternative for pre-surgical mapping of eloquent cortex for children, paradigms and analyses demonstrating concordance with independent measures must be developed. [ABSTRACT FROM AUTHOR]

Published
2017
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29. P68 * UNRAVELLING GRADE 3 GLIOMAS

Author

Mathew, R. K., primary, Goacher, E., additional, Bhargava, D., additional, Chakrabarty, A., additional, Roberts, P., additional, Goodden, J., additional, Loughrey, C., additional, and Chumas, P. D., additional

Published
2014
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31. O8.09 * THE LEEDS LOW GRADE GLIOMA SERVICE 2010-13

Author

Mathew, R., primary, Spink, S., additional, O'Hara, D., additional, Loughrey, C., additional, Wright, E., additional, Chakrabarty, A., additional, Patankar, T., additional, MacMullen-Price, J., additional, Goodden, J., additional, and Chumas, P., additional

Published
2014
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35. QUALITY OF LIFE/AFTERCARE

Author

Rednam, S., primary, Scheurer, M., additional, Adesina, A., additional, Lau, C., additional, Okcu, M., additional, Deatrick, J., additional, Ogle, S., additional, Fisher, M., additional, Barakat, L., additional, Hardie, T., additional, Li, Y., additional, Ginsberg, J., additional, Ben-Arush, M., additional, Krivoy, E., additional, Rosenkranz, R., additional, Peretz-Nahum, M., additional, Brown, R. J., additional, Love, J., additional, Warburton, D., additional, McBride, W. H., additional, Bluml, S., additional, Mueller, S., additional, Sear, K., additional, Hills, N., additional, Chettout, N., additional, Afghani, S., additional, Lew, L., additional, Tolentino, E., additional, Haas-Kogan, D., additional, Fullerton, H., additional, Reddick, W., additional, Palmer, S., additional, Glass, J., additional, Ogg, R., additional, Gajjar, A., additional, Omar, A., additional, Perkins, S., additional, Shinohara, E., additional, Spoljaric, D., additional, Isenberg, J., additional, Whittington, M., additional, Hauff, M., additional, King, A., additional, Litzelman, K., additional, Barker, E., additional, Catrine, K., additional, Puccetti, D., additional, Possin, P., additional, Witt, W., additional, Mallucci, C., additional, Kumar, R., additional, Pizer, B., additional, Williams, D., additional, Pettorini, B., additional, Piscione, J., additional, Bouffet, E., additional, Shams, I., additional, Kulkarni, A., additional, Remes, T., additional, Harila-Saari, A., additional, Suo-Palosaari, M., additional, Arikoski, P., additional, Riikonen, P., additional, Sutela, A., additional, Koskenkorva, P., additional, Ojaniemi, M., additional, Rantala, H., additional, Campen, C. J., additional, Ashby, D., additional, Fisher, P. G., additional, Monje, M., additional, Kulkarni, A. V., additional, Nakamura, H., additional, Makino, K., additional, Yano, S., additional, Kuratsu, J.-i., additional, Jadrijevic-Cvrlje, F., additional, Batinica, M., additional, Toledano, H., additional, Hoffman, T., additional, Ezer-Cohen, Y., additional, Michowiz, S., additional, Yaniv, I., additional, Cohen, I. J., additional, Adler, I., additional, Mindel, S., additional, Gopalakrishnamoorthy, M., additional, Saunders, D., additional, Gaze, M., additional, Spoudeas, H., additional, Kieffer, V., additional, Dellatolas, G., additional, Chevignard, M., additional, Puget, S., additional, Dhermain, F., additional, Grill, J., additional, Dufour, C., additional, Muir, R., additional, Hunter, A., additional, Latchman, A., additional, de Camargo, O., additional, Scheinemann, K., additional, Dhir, N., additional, Zaky, W., additional, Zomorodian, T., additional, Wong, K., additional, Dhall, G., additional, Macy, M., additional, Lauro, C., additional, Zeitler, P., additional, Foreman, N., additional, Liu, A., additional, Chocholous, M., additional, Dodier, P., additional, Peyrl, A., additional, Dieckmann, K., additional, Hausler, G., additional, Slavc, I., additional, Avula, S., additional, Garlick, D., additional, Armstrong, G., additional, Kawashima, T., additional, Leisenring, W., additional, Stovall, M., additional, Sklar, C., additional, Robison, L., additional, Samaan, C., additional, Duckworth, J., additional, Greenberg-Kushnir, N., additional, Freedman, S., additional, Eshel, R., additional, Zverling, N., additional, Elhasid, R., additional, Dvir, R., additional, Yalon, M., additional, Constantini, S., additional, Wilne, S., additional, Liu, J.-F., additional, Trusler, J., additional, Lundsell, S., additional, Kennedy, C., additional, Clough, L., additional, Dickson, N., additional, Lakhanpaul, M., additional, Baker, M., additional, Dudley, J., additional, Grundy, R., additional, Walker, D., additional, von Hoff, K., additional, Herzog, N., additional, Ottensmeier, H., additional, Grabow, D., additional, Gerber, N. U., additional, Friedrich, C., additional, von Bueren, A. O., additional, Resch, A., additional, Kortmann, R. D., additional, Kaatsch, P., additional, Doerr, H. G., additional, Rutkowski, S., additional, del Bufalo, F., additional, Mastronuzzi, A., additional, Serra, A., additional, de Sio, L., additional, Locatelli, F., additional, Biassoni, V., additional, Leonardi, M., additional, Ajovalasit, D., additional, Riva, D., additional, Vago, C., additional, Usilla, A., additional, Fidani, P., additional, Schiavello, E., additional, Gariboldi, F., additional, Massimino, M., additional, Lober, R., additional, Perrault, S., additional, Partap, S., additional, Edwards, M., additional, Fisher, P., additional, Yeom, K., additional, Salgado, D., additional, Nunes, S., additional, Vinhais, S., additional, Wells, E. M., additional, Seidel, K., additional, Ullrich, N. J., additional, Diller, L., additional, Krull, K. R., additional, Neglia, J., additional, Robison, L. L., additional, Whelan, K., additional, Russell, C. E., additional, Brownstone, D., additional, Kaise, C., additional, Bull, K., additional, Culliford, D., additional, Calaminus, G., additional, Bertin, D., additional, Vallero, S., additional, Romano, E., additional, Basso, M. E., additional, Biasin, E., additional, Fagioli, F., additional, Ziara, K., additional, L'Hotta, A., additional, Williams, A., additional, Thede, R., additional, Moore, K., additional, James, A., additional, Bjorn, E., additional, Franzen, P., additional, Haag, A., additional, Lax, A.-K., additional, Moreno, I., additional, Obeid, J., additional, Timmons, B. W., additional, Iwata, W., additional, Wagner, S., additional, Lai, J.-S., additional, Waddell, K., additional, VanLeeuwen, S., additional, Newmark, M., additional, Noonan, J., additional, O'Connell, K., additional, Urban, M., additional, Yount, S., additional, Goldman, S., additional, Igoe, D., additional, Cunningham, T., additional, Orfus, M., additional, Mabbott, D., additional, Liptak, C., additional, Manley, P., additional, Recklitis, C., additional, Zhang, P., additional, Shaikh, F., additional, Narang, I., additional, Matsumoto, K., additional, Yamasaki, K., additional, Okada, K., additional, Fujisaki, H., additional, Osugi, Y., additional, Hara, J., additional, Phipps, K., additional, Gumley, D., additional, Jacques, T., additional, Hargrave, D., additional, Michalski, A., additional, Chordas, C., additional, Chi, S., additional, Robison, N., additional, Bandopadhayay, P., additional, Marcus, K., additional, Zimmerman, M. A., additional, Goumnerova, L., additional, Kieran, M., additional, Brand, S., additional, Brinkman, T., additional, Delaney, B., additional, Diver, T., additional, Rey, C., additional, Madden, J. R., additional, Hemenway, M. S., additional, Dorneman, L., additional, Stiller, D., additional, Liu, A. K., additional, Foreman, N. K., additional, Vibhakar, R., additional, Mitchell, M., additional, Hemenway, M., additional, Madden, J., additional, Ryan, M., additional, O'Kane, R., additional, Picton, S., additional, Kenny, T., additional, Stiller, C., additional, Chumas, P., additional, Bendel, A., additional, Patterson, R., additional, Barrera, M., additional, Schulte, F., additional, Bartels, U., additional, Janzen, L., additional, Johnston, D., additional, Cataudella, D., additional, Chung, J., additional, Sung, L., additional, Hancock, K., additional, Hukin, J., additional, Zelcer, S., additional, Brandon, S., additional, Montour-Proulx, I., additional, Strother, D., additional, Cooksey, R., additional, Bowers, D., additional, Gargan, L., additional, Gode, A., additional, Klesse, L., additional, Oden, J., additional, Vega, G., additional, Sala, F., additional, Nuzzi, D., additional, Mulino, M., additional, Masotto, B., additional, Mazza, C., additional, Bricolo, A., additional, Gerosa, M., additional, Tong, M., additional, Laughlin, S., additional, Mackie, S., additional, Taylor, L., additional, Sharpe, G., additional, Al-Salihi, O., additional, and Nicolin, G., additional

Published
2012
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36. EPIDEMIOLOGY

Author

Khatua, S., primary, Brown, R., additional, Pearlman, M., additional, Vats, T., additional, Satge, D., additional, Stiller, C., additional, Rutkowski, S., additional, von Bueren, A. O., additional, Lacour, B., additional, Sommelet, D., additional, Nishi, M., additional, Massimino, M., additional, Garre, M.-L., additional, Moreno, F., additional, Hasle, H., additional, Jakab, Z., additional, Greenberg, M., additional, von der Weid, N., additional, Kuehni, C., additional, Zurriaga, O., additional, Vicente, M.-L., additional, Peris-Bonet, R., additional, Benesch, M., additional, Vekemans, M., additional, Sullivan, S., additional, Rickert, C., additional, Fisher, P. G., additional, Von Behren, J., additional, Nelson, D. O., additional, Reynolds, P., additional, Fukuoka, K., additional, Yanagisawa, T., additional, Suzuki, T., additional, Koga, T., additional, Wakiya, K., additional, Adachi, J.-i., additional, Mishima, K., additional, Fujimaki, T., additional, Matsutani, M., additional, Nishikawa, R., additional, Gidding, C., additional, Schieving, J., additional, Wesseling, P., additional, Ligtenberg, M., additional, Hoogerbrugge, N., additional, Jongmans, M., additional, Crosier, S., additional, Nicholson, S. L., additional, Robson, K., additional, Jacques, T., additional, Wharton, S., additional, Bown, N., additional, Michalski, A., additional, Pizer, B., additional, Clifford, S., additional, Sanden, E., additional, Visse, E., additional, Siesjo, P., additional, Darabi, A., additional, Nousome, D., additional, Lupo, P. J., additional, Scheurer, M. E., additional, Nulman, I., additional, Barrera, M., additional, Maxwell, C., additional, Koren, G., additional, Gorelyshev, S., additional, Matuev, K., additional, Lubnin, A., additional, Laskov, M., additional, Lemeneva, N., additional, Mazerkina, N., additional, Khuhlaeva, E., additional, Muller, K., additional, Bruns, F., additional, Pietsch, T., additional, Kortmann, R.-D., additional, Krishnatry, R., additional, Shirsat, N., additional, Kunder, R., additional, Epari, S., additional, Gupta, T., additional, Kurkure, P., additional, Vora, T., additional, Arora, B., additional, Moiyadi, A., additional, Jalali, R., additional, Swieszkowska, E., additional, Dembowska-Baginska, B., additional, Drogosiewicz, M., additional, Filipek, I., additional, Perek-Polnik, M., additional, Grajkowska, W., additional, Perek, D., additional, Johnston, D., additional, Cyr, J., additional, Strother, D., additional, Lafay-Cousin, L., additional, Fryer, C., additional, Scheinemann, K., additional, Carret, A.-S., additional, Fleming, A., additional, Larouche, V., additional, Bouffet, E., additional, Friedrich, C., additional, Gnekow, A. K., additional, Fleischhack, G., additional, Kramm, C. M., additional, Fruehwald, M. C., additional, Muller, H. L., additional, Calaminus, G., additional, Kordes, U., additional, Faldum, A., additional, Warmuth-Metz, M., additional, Kortmann, R. D., additional, Jung, I., additional, Kaatsch, P., additional, Caretti, V., additional, Bugiani, M., additional, Boor, I., additional, Schellen, P., additional, Vandertop, W. P., additional, Noske, D. P., additional, Kaspers, G., additional, Wurdinger, T., additional, Robinson, G., additional, Chingtagumpala, M., additional, Adesina, A., additional, Dalton, J., additional, Santi, M., additional, Sievert, A., additional, Wright, K., additional, Armstrong, G., additional, Boue, D., additional, Olshefski, R., additional, Scott, S., additional, Huang, A., additional, Cohn, R., additional, Gururangan, S., additional, Bowers, D., additional, Gilbertson, R., additional, Gajjar, A., additional, Ellison, D., additional, Chick, E., additional, Donson, A., additional, Owens, E., additional, Smith, A. A., additional, Madden, J. R., additional, Foreman, N. K., additional, Bakry, D., additional, Aronson, M., additional, Durno, C., additional, Hala, R., additional, Farah, R., additional, Amayiri, N., additional, Alharbi, Q., additional, Shamvil, A., additional, Ben-Shachar, S., additional, Constantini, S., additional, Rina, D., additional, Ellise, J., additional, Keiles, S., additional, Pollet, A., additional, Qaddoumi, I., additional, Gallinger, S., additional, Malkin, D., additional, Hawkins, C., additional, Tabori, U., additional, Trivedi, M., additional, Goodden, J., additional, Chumas, P., additional, Tyagi, A., additional, O'kane, R., additional, O'Kane, R., additional, Crimmins, D., additional, Picton, S., additional, and Elliott, M., additional

Published
2012
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37. GERM CELL TUMORS

Author

Yang, Q.-y., primary, Chen, Z.-p., additional, Hayase, T., additional, Gomi, A., additional, Higaki, A., additional, Kawahara, Y., additional, Kobari, T., additional, Fukuda, T., additional, Kashii, Y., additional, Morimoto, A., additional, Sakatani, T., additional, Momoi, M. Y., additional, Murray, M., additional, Hale, J., additional, Heinemann, K., additional, Saran, F., additional, Calaminus, G., additional, Nicholson, J., additional, Martinez, S., additional, Khakoo, Y., additional, Gilheeney, S., additional, Kramer, K., additional, Wolden, S., additional, Souweidane, M., additional, Dunkel, I., additional, Brichtova, E., additional, Pavelka, Z., additional, Bobekova, A., additional, Magnova, O., additional, Kren, L., additional, Svoboda, T., additional, Sprlakova, A., additional, Slampa, P., additional, Zitterbart, K., additional, Sterba, J., additional, Campen, C. J., additional, Ashby, D., additional, Fisher, P. G., additional, Monje, M., additional, Dagri, J., additional, Torkildson, J., additional, Cheng, J., additional, Wang, R. X., additional, Yock, T., additional, Banerjee, A., additional, Dhall, G., additional, Finlay, J., additional, Yanagisawa, T., additional, Fukuoka, K., additional, Suzuki, T., additional, Kohga, T., additional, Wakiya, K., additional, Adachi, J., additional, Mishima, K., additional, Fujimaki, T., additional, Matsutani, M., additional, Nishikawa, R., additional, Frappaz, D., additional, Kortmann, R. D., additional, Alapetite, C., additional, Garre, M. L., additional, Ricardi, U., additional, Saran, F. H., additional, Czech, T., additional, Walker, R., additional, Koga, T., additional, Legault, G., additional, Allen, J., additional, Geludkova, O., additional, Mushinskaya, M., additional, Kushel, Y., additional, Korshunov, A., additional, Melikyan, A., additional, Shishkina, L., additional, Oserova, V., additional, Oserov, S., additional, Maserkina, N., additional, Borodina, I., additional, Kumirova, E., additional, Boyarchuk, N., additional, Gorbatyh, S., additional, Popova, E., additional, Sherbenko, O., additional, Zelinskaya, N., additional, Shammasov, R., additional, Privalova, L., additional, Chulkov, O., additional, Kosel, Y., additional, Cappellano, A. M., additional, Paiva, P., additional, Cavalheiro, S., additional, Dastoli, P., additional, Seixas, M. T., additional, Silva, N. S., additional, Chan, G. C.-F., additional, Shing, M. M.-K., additional, Yuen, H.-L., additional, Li, R. C.-H., additional, Li, C.-K., additional, Ha, S.-Y., additional, Chen, H.-H., additional, Chang, F.-C., additional, Chen, Y.-W., additional, Wong, T.-T., additional, Yarascavitch, B., additional, Stein, N., additional, Ribeiro, L., additional, Whitton, A., additional, Duckworth, J., additional, Scheinemann, K., additional, Singh, S., additional, Ozerov, S., additional, Gorelyshev, S., additional, Trunin, Y., additional, Kagawa, N., additional, Fujimoto, Y., additional, Hirayama, R., additional, Chiba, Y., additional, Kijima, N., additional, Arita, H., additional, Kinoshita, M., additional, Hashimoto, N., additional, Maruno, M., additional, Yoshimine, T., additional, Guerra, G. P., additional, Oscanoa, M., additional, Cavero, L., additional, Yabar, A., additional, Ugarte, E., additional, Trivedi, M., additional, Tyagi, A., additional, Goodden, J., additional, Chumas, P., additional, Elliott, M., additional, Picton, S., additional, Robison, N., additional, Prabhu, S., additional, Sun, P., additional, Chi, S., additional, Kieran, M., additional, Manley, P., additional, Cohen, L., additional, Goumnerova, L., additional, Smith, E., additional, Scott, M., additional, London, W., additional, and Ullrich, N. J., additional

Published
2012
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38. Abstracts from the 2011 BNOS Conference, June 29 - July 1, 2011, Homerton College, Cambridge

Author

Ammoun, S., primary, Zhou, L., additional, Barczyk, M., additional, Hilton, D., additional, Hafizi, S., additional, Hanemann, C., additional, Lehnus, K. S., additional, Donovan, L. K., additional, Pilkington, G. J., additional, An, Q., additional, Anderson, I. A., additional, Thomson, S., additional, Bailey, M., additional, Lekka, E., additional, Law, J., additional, Davis, C., additional, Banfill, K., additional, Loughrey, C., additional, Hatfield, P., additional, Bax, D., additional, Elliott, R., additional, Bishop, R., additional, Taylor, K., additional, Marshall, L., additional, Gaspar, N., additional, Viana-Pereira, M., additional, Reis, R., additional, Renshaw, J., additional, Ashworth, A., additional, Lord, C., additional, Jones, C., additional, Bellamy, C., additional, Shaw, L., additional, Alder, J., additional, Shorrocks, A., additional, Lea, R., additional, Birks, S., additional, Burnet, M., additional, Pilkington, G., additional, Bruch, J. D., additional, Ho, J., additional, Watts, C., additional, Price, S. J., additional, Camp, S., additional, Apostolopoulos, V., additional, Mehta, A., additional, Roncaroli, F., additional, Nandi, D., additional, Clark, B., additional, Mackinnon, M., additional, MacLeod, N., additional, Stewart, W., additional, Chalmers, A., additional, Cole, A., additional, Hanna, G., additional, Bailie, K., additional, Conkey, D., additional, Harney, J., additional, Darlow, C., additional, Chapman, S., additional, Mohsen, L., additional, Price, S., additional, Donovan, L., additional, Dyer, H., additional, Lord, H., additional, Fletcher, K., additional, das Nair, R., additional, MacNiven, J., additional, Basu, S., additional, Byrne, P., additional, Glancz, L., additional, Critchley, G., additional, Grech-Sollars, M., additional, Saunders, D., additional, Phipps, K., additional, Clayden, J., additional, Clark, C., additional, Greco, A., additional, Acquati, S., additional, Marino, S., additional, Hammouche, S., additional, Wilkins, S. P., additional, Smith, T., additional, Brodbelt, A., additional, Clark, S., additional, Wong, A. H. L., additional, Eldridge, P., additional, Farah, J. O., additional, Bruch, J., additional, Lamb, G., additional, Smith, S., additional, James, A., additional, Glegg, M., additional, Jeffcote, T., additional, Boulos, S., additional, Robbins, P., additional, Knuckey, N., additional, Banigo, A., additional, Brodbelt, A. R., additional, Jenkinson, M. D., additional, Jeyapalan, J. N., additional, Mumin, M. A., additional, Forshew, T., additional, Lawson, A. R., additional, Tatevossian, R. G., additional, Jacques, T. S., additional, Sheer, D., additional, Kilday, J., additional, Wright, K., additional, Leavy, S., additional, Lowe, J., additional, Schwalbe, E., additional, Clifford, S., additional, Gilbertson, R., additional, Coyle, B., additional, Grundy, R., additional, Kinsella, P., additional, Clynes, M., additional, Amberger-Murphy, V., additional, Barron, N., additional, Lambert, S. R., additional, Jones, D., additional, Pearson, D., additional, Ichimura, I., additional, Collins, V., additional, Steele, L., additional, Sinha, P., additional, Chumas, P., additional, Tyler, J., additional, Ogawa, D., additional, Chiocca, E., additional, DeLay, M., additional, Bronisz, A., additional, Nowicki, M., additional, Godlewski, J., additional, Lawler, S., additional, Lee, M. K., additional, Javadpour, M., additional, Abel, P., additional, Dawson, T., additional, Lea, B., additional, Lim, C. S.-K., additional, Grundy, P. L., additional, Pendleton, M., additional, Williamson, A., additional, Merve, A., additional, Zhang, X., additional, Miller, S., additional, Rogers, H. A., additional, Lyon, P., additional, Rand, V., additional, Adamowicz-Brice, M., additional, Clifford, S. C., additional, Hayden, J. T., additional, Dyer, S., additional, Pfister, S., additional, Korshunov, A., additional, Brundler, M.-A., additional, Grundy, R. G., additional, Nankivell, M., additional, Mulvenna, P., additional, Barton, R., additional, Wilson, P., additional, Faivre-Finn, C., additional, Pugh, C., additional, Langley, R., additional, Ngoga, D., additional, Tennant, D., additional, Williams, A., additional, Moss, P., additional, Cruickshank, G., additional, Owusu-Agyemang, K., additional, Bell, S., additional, St.George, J., additional, Piccirillo, S. G., additional, Qadri, S., additional, Pirola, E., additional, Jenkinson, M., additional, Rahman, R., additional, Rahman, C., additional, MacArthur, D., additional, Rose, F., additional, Shakesheff, K., additional, Carroll, C., additional, Watson, P., additional, Hawkins, M., additional, Spoudeas, H., additional, Walker, D., additional, Holland, T., additional, Ring, H., additional, Rooney, A., additional, McNamara, S., additional, Fraser, M., additional, Rampling, R., additional, Carson, A., additional, Grant, R., additional, Royds, J., additional, Al Nadaf, S., additional, Ahn, A., additional, Chen, Y.-J., additional, Wiles, A., additional, Jellinek, D., additional, Braithwaite, A., additional, Baguley, B., additional, MacFarlane, M., additional, Hung, N., additional, Slatter, T., additional, Rusbridge, S., additional, Walmsley, N., additional, Griffiths, S., additional, Wilford, P., additional, Rees, J., additional, Ryan, D., additional, Liu, P., additional, Galavotti, S., additional, Shaked-Rabi, M., additional, Tulchinsky, E., additional, Brandner, S., additional, Salomoni, P., additional, Schulte, A., additional, Gunther, H. S., additional, Zapf, S., additional, Riethdorf, S., additional, Westphal, M., additional, Lamszus, K., additional, Selvanathan, S. K., additional, Salminen, H. J., additional, Setua, S., additional, Welland, M. E., additional, Shevtsov, M., additional, Khachatryan, W., additional, Kim, A., additional, Samochernych, K., additional, Pozdnyakov, A., additional, Guzhova, I. V., additional, Romanova, I. V., additional, Margulis, B., additional, Barrow, J., additional, Macarthur, D., additional, Long, A., additional, Maherally, Z., additional, Smith, J. R., additional, Dickson, L., additional, Prabhu, S., additional, Harris, F., additional, Snape, T. 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E., additional, Shepherd, S., additional, Scott, S., additional, Bowyer, D., additional, Wallace, L., additional, Hacking, B., additional, Jena, R., additional, Gillard, J., additional, Verraeult, M., additional, Reynolds, B., additional, Dunham, C., additional, Bally, M., additional, Hukin, J., additional, Singhal, S., additional, Singh, S., additional, and Dunn, S., additional

Published
2011
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39. Investigations on a clinically and functionally unusual and novel germline p53 mutation.

Author

Rutherford, J, Chu, CE, Duddy, PM, Charlton, RS, Chumas, P, Taylor, GR, Lu, X, Barnes, DM, Camplejohn, RS, Rutherford, J, Chu, CE, Duddy, PM, Charlton, RS, Chumas, P, Taylor, GR, Lu, X, Barnes, DM, and Camplejohn, RS

Abstract

This report describes an individual with a rare choroid plexus papilloma in adulthood (age 29) after earlier having an osteosarcoma (age 22). The results from this study, and others, suggest that it may be advisable to consider the possibility of a germline p53 mutation in adults presenting with choroid plexus tumours. In the current study automated DNA sequencing of genomic DNA detected a novel germline 7 base pair insertion in exon 5 of the p53 gene in this patient. The alteration in frame would produce amino acid substitutions beginning with alanine to glycine at position 161 and a stop codon at position 182 in the mutated protein. Surprisingly two assays of p53 function gave apparently wild-type results on peripheral blood lymphocytes from this individual. These results led us to carry out more detailed functional tests on the mutant protein. The mutant allele was expressed either at very low levels or not at all in phytohaemagglutinin stimulated lymphocytes. Further, the mutant protein was completely non-functional in terms of its ability to transactivate a series of p53-responsive genes (p21(WAF1), bax, PIG3), to transrepress a target gene and to inhibit colony growth in transfected Saos-2 cells. However, surprisingly, data from irradiated peripheral blood lymphocytes and transfected Saos-2 cells, suggested that this truncated, mutant protein retains significant ability to induce apoptosis.

Published
2002

43. 13th European Congress of Neurosurgery, September 2nd–7th, 2007, Glasgow.

Author

Benes, V., Casey, A., Chumas, P., Hutchinson, P., Mooij, J.-J., Sindou, M., Teasdale, G., and Whittle, I.

Subjects
CONFERENCES & conventions, NEUROSURGERY
Abstract

The article presents information related to the 13th European Congress of Neurosurgery, which was held on September 2-7, 2007, in Glasgow, Scotland. As reported, the congress was held under the leadership of Ken Lindsay, the President of the European Association of Neurological Societies (EANS), with the support of the Society of British Neurological Surgeons. The speakers at the conference include Professor G. Raisman of the Medical Research Council of Great Britain.

Published
2008
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44. Incidence of childhood CNS tumours in Britain and variation in rates by definition of malignant behaviour: population-based study.

Author

Stiller, C.A., Bayne, A.M., Chakrabarty, A., Kenny, Tom, Chumas, P., Stiller, C.A., Bayne, A.M., Chakrabarty, A., Kenny, Tom, and Chumas, P.

Abstract

BACKGROUND: Intracranial and intraspinal tumours are the most numerous solid tumours in children. Some recently defined subtypes are relatively frequent in childhood. Many cancer registries routinely ascertain CNS tumours of all behaviours, while others only cover malignant neoplasms. Some behaviour codes have changed between revisions of the International Classification of Diseases for Oncology, including pilocytic astrocytoma, downgraded to uncertain behaviour in ICD-O-3. METHODS: We used data from the population-based National Registry of Childhood Tumours, which routinely included non-malignant CNS tumours, to document the occurrence of CNS tumours among children aged < 15 years in Great Britain during 2001-2010 and to document the descriptive epidemiology of childhood CNS tumours over the 40-year period 1971-2010, during which several new entities were accommodated in successive editions of the WHO Classification and revisions of ICD-O. Eligible cases were all those with a diagnosis included in Groups III (CNS tumours) and Xa (CNS germ-cell tumours) of the International Classification of Childhood Cancer, Third Edition. The population at risk was derived from annual mid-year estimates by sex and single year of age compiled by the Office for National Statistics and its predecessors. Incidence rates were calculated for age groups 0, 1-4, 5-9 and 10-14 years, and age-standardised rates were calculated using the weights of the world standard population. RESULTS: Age-standardised incidence in 2001-10 was 40.1 per million. Astrocytomas accounted for 41%, embryonal tumours for 17%, other gliomas for 10%, ependymomas for 7%, rarer subtypes for 20% and unspecified tumours for 5%. Incidence of tumours classified as malignant and non-malignant by ICD-O-3 increased by 30 and 137% respectively between 1971-75 and 2006-10. CONCLUSIONS: Total incidence was similar to that in other large western countries. Deficits of some, predominantly low-grade, tumours or differences in th

48. Motor seizures confer overall survival benefit in who grade 2 glioma.

Author

Fairclough S, Chumas P, Goodden J, Maguire M, and Mathew RK

Subjects
Humans, Male, Female, Middle Aged, Adult, Aged, Young Adult, World Health Organization, Retrospective Studies, Neoplasm Grading, Adolescent, Glioma mortality, Glioma complications, Glioma surgery, Glioma pathology, Brain Neoplasms mortality, Brain Neoplasms complications, Brain Neoplasms pathology, Seizures etiology, Seizures mortality
Abstract

Objective: The prevalence of epilepsy in World Health Organization (WHO) grade 2 glioma is high, with seizures being the presenting symptom in 60%-90%. We explore the epidemiology of seizures in this patient population in a regional neurosurgical center., Methods: Electronic health records of patients with histologically-proven WHO grade 2 glioma (n = 228) were reviewed between 1997 and 2021, with data collected including patient demographics, epilepsy prevalence, and seizure semiology. The influence of seizure type on overall survival was calculated using a Cox proportional hazards model., Results: Overall, 197 of 228 patients (86.4%) were diagnosed with epilepsy-either at presentation or during the course of their disease. Male patients were more likely than female patients to be diagnosed with epilepsy (91.1% vs 77.1%, p = .003) and, in those with epilepsy, more likely to experience at least one focal to bilateral tonic-clonic seizure (69.4% vs 54.1%, p = .05). Patients with left-sided tumors were twice as likely to have experienced a focal to bilateral tonic-clonic seizure (p = .02, odds ratio [OR] = .47). Predominantly experiencing seizures with motor activity appeared to confer better overall survival, with a 65% decrease in the risk of death 10 years post diagnosis (hazard ratio [HR] = .35, p = .02). This is despite accounting for previously described prognostic markers including tumor histology/genetics, time from diagnosis to surgery, and the extent of tumor resection., Significance: Motor seizure activity is a frequent feature in WHO grade 2 glioma and appears to confer a survival benefit regardless of histology or surgical factors. Seizures due to dominant hemisphere tumors may be more likely to propagate and cause bilateral tonic-clonic activity., (© 2024 The Authors. Epilepsia published by Wiley Periodicals LLC on behalf of International League Against Epilepsy.)

Published
2024
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49. Management of glioblastoma in elderly patients: A review of the literature.

Author

Mazarakis NK, Robinson SD, Sinha P, Koutsarnakis C, Komaitis S, Stranjalis G, Short SC, Chumas P, and Giamas G

Abstract

High grade gliomas are the most common primary aggressive brain tumours with a very poor prognosis and a median survival of less than 2 years. The standard management protocol of newly diagnosed glioblastoma patients involves surgery followed by radiotherapy, chemotherapy in the form of temozolomide and further adjuvant temozolomide. The recent advances in molecular profiling of high-grade gliomas have further enhanced our understanding of the disease. Although the management of glioblastoma is standardised in newly diagnosed adult patients there is a lot of debate regarding the best treatment approach for the newly diagnosed elderly glioblastoma patients. In this review article we attempt to summarise the findings regarding surgery, radiotherapy, chemotherapy, and their combination in order to offer the best possible management modality for this group of patients. Elderly patients 65-70 with an excellent functional level could be considered as candidates for the standards treatment consisting of surgery, standard radiotherapy with concomitant and adjuvant temozolomide. Similarly, elderly patients above 70 with good functional status could receive the above with the exception of receiving a shorter course of radiotherapy instead of standard. In elderly GBM patients with poorer functional status and MGMT promoter methylation temozolomide chemotherapy can be considered. For elderly patients who cannot tolerate chemotherapy, hypofractionated radiotherapy is an option. In contrast to the younger adult patients, it seems that a careful individualised approach is a key element in deciding the best treatment options for this group of patients., Competing Interests: The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper., (© 2024 The Authors. Published by Elsevier B.V. on behalf of European Society for Radiotherapy and Oncology.)

Published
2024
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50. Levetiracetam as a first-line antiseizure medication in WHO grade 2 glioma: Time to seizure freedom and rates of treatment failure.

Author

Fairclough S, Goodden J, Chumas P, Mathew R, and Maguire M

Subjects
Humans, Levetiracetam therapeutic use, Anticonvulsants therapeutic use, Carbamazepine therapeutic use, Seizures etiology, Seizures chemically induced, Treatment Failure, Freedom, World Health Organization, Epilepsies, Partial drug therapy, Epilepsy drug therapy, Epilepsy chemically induced, Glioma complications, Glioma drug therapy
Abstract

Objective: The high seizure burden seen in World Health Association (WHO) grade 2 gliomas is well documented. This study aims to identify factors that influence the probability of seizure freedom (12 months of seizure remission) and treatment failure (antiseizure medication [ASM] cessation or introduction of an alternative) in patients with WHO grade 2 glioma., Methods: This is a retrospective observational analysis of patients from a regional UK neurosurgical center with histologically proven (n = 146) WHO grade 2 glioma and brain tumor related epilepsy. Statistical analyses using both Kaplan-Meier and Cox proportional hazards models were undertaken, with a particular focus on treatment outcomes when the commonly prescribed ASM levetiracetam (n = 101) is used as first line., Results: Treatment with levetiracetam as a first-line ASM resulted in a significant increase in the probability of seizure freedom (p < .05) at 2 years compared with treatment with an alternative ASM. Individuals presenting with focal seizures without bilateral tonic-clonic progression were between 39% and 42% significantly less likely to reach seizure freedom within 10 years (p < .05) and 132% more likely to fail treatment by 5 years (p < .01) when compared to individuals who had seizures with progression to bilateral tonic-clonic activity. ASM choice did not significantly affect treatment failure rates., Significance: More than two-thirds of patients with WHO grade 2 glioma related epilepsy treated with levetiracetam first line achieve seizure freedom within 2 years and it is a reasonable first-choice agent. Experiencing mainly focal seizures without progression infers a significant long-term reduction in the chance of seizure freedom. Further studies are needed to inform ASM selection., (© 2023 The Authors. Epilepsia published by Wiley Periodicals LLC on behalf of International League Against Epilepsy.)

Published
2023
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