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16. The Association between Statin Use and Reduced Migraine Likelihood: A Comprehensive Analysis of Migraine Subtypes and Statin Types in a Nationwide Korean Cohort.

Author

Kang, Ho Suk, Kim, Joo-Hee, Kim, Ji Hee, Bang, Woo Jin, Yoo, Dae Myoung, Lee, Na-Eun, Han, Kyeong Min, Kim, Nan Young, Choi, Hyo Geun, Min, Kyueng-Whan, and Kwon, Mi Jung

Subjects
MIGRAINE aura, NATIONAL health insurance, PROPENSITY score matching, KOREANS, STATINS (Cardiovascular agents)
Abstract

Despite growing interest in the preventive effects of statins, as lipid-lowering agents, on migraine attacks, comprehensive nationwide studies comparing migraine likelihood between statin users and controls are lacking. Our nested case–control study within the Korean National Health Insurance Service-Health Screening Cohort (2002–2019) investigated this association using 38,957 migraine patients and 155,828 controls, considering migraine subtypes (with/without aura) and statin types (lipophilic vs. hydrophilic). Using propensity score matching and adjusting for confounders, statin use was linked to reduced migraine likelihood overall (odds ratio (OR) 0.93), particularly for migraines with aura (OR 0.75) and without aura (OR 0.94). Lipophilic statins were effective for both subtypes, while hydrophilic statins mainly reduced the likelihood of migraines without aura. Subgroup analyses showed consistent benefits across demographics, but varied effectiveness based on weight, smoking, alcohol use, hemoglobin levels, and dyslipidemia history. In summary, this nationwide cohort study suggests that statin use may reduce migraine likelihood among Korean adults across diverse demographics and clinical profiles, but varied effectiveness based on certain lifestyle and comorbidity factors underscores the importance of considering individual patient profiles when assessing the potential benefits of statin therapy for migraine prevention. [ABSTRACT FROM AUTHOR]

Published
2024
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17. The Association of Chronic Periodontitis as a Potential Risk Factor with Rheumatoid Arthritis: A Nested Case-Control Study Using a Korean National Health Screening Cohort

Author

Kang, Ho Suk, primary, Kim, Joo-Hee, additional, Kim, Ji Hee, additional, Bang, Woo Jin, additional, Choi, Hyo Geun, additional, Yoo, Dae Myoung, additional, Lee, Na-Eun, additional, Han, Kyeong Min, additional, Kim, Nan Young, additional, Park, Ha Young, additional, Min, Kyueng-Whan, additional, and Kwon, Mi Jung, additional

Published
2024
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25. Association between Gastric Cancer and Osteoporosis: A Longitudinal Follow-Up Study Using a National Health Sample Cohort.

Author

Han, Kyeong Min, Kwon, Mi Jung, Kim, Joo-Hee, Kim, Ji Hee, Bang, Woo Jin, Choi, Hyo Geun, Yoo, Dae Myoung, Lee, Na-Eun, Kim, Nan Young, and Kang, Ho Suk

Subjects
RISK assessment, STOMACH tumors, RESEARCH funding, LONGITUDINAL method, KAPLAN-Meier estimator, OSTEOPOROSIS, COMPARATIVE studies, DISEASE risk factors, DISEASE complications
Abstract

Simple Summary: Using data from the Korean National Health Insurance Service—National Sample Cohort database, we evaluated whether patient-specific factors such as age, sex, income, residence, and the presence of comorbidities influence the relationship between gastric cancer (GC) and the likelihood of developing osteoporosis. Our study, with 1:4 propensity score matching and a stratified Cox proportional hazards model, showed that the hazard ratio of osteoporosis for the GC group was 1.13 (95%CI, 1.03–1.24) compared to that for the control group. In addition, subgroup analysis showed that age < 65 years, male sex, and a Charlson Comorbidity Index of 0 were risk factors for osteoporosis. Gastric cancer (GC) survivors may be more likely to develop osteoporosis. However, few studies on the relationship between GC and osteoporosis have been conducted on large patient populations. We aimed to determine the incidence of osteoporosis and identify related factors by comparing patients with GC and matched controls using the Korean National Health Insurance Service—National Sample Cohort (KNHIS-NSC). This study included 9078 patients with GC and 36,312 controls (1:4 propensity score-matched for sex, age, residence, and income). The hazard ratio (HR) for osteoporosis was significantly greater for GC patients than for controls according to Charlson Comorbidity Index (CCI) score-adjusted models (adjusted HR = 1.13). Kaplan–Meier analysis revealed that the cumulative incidence of osteoporosis during the follow-up period commencing from the index date was significantly greater in GC patients than in the controls (p = 0.0087). A positive correlation of osteoporosis with GC was detected for those aged < 65 years, males, and those with CCI scores = 0. In conclusion, the study findings suggest that men with GC aged < 65 years may be at an increased risk for osteoporosis. Research into additional risk factors and the optimal timing of interventions are needed to prevent fractures and minimize bone loss in GC survivors. [ABSTRACT FROM AUTHOR]

Published
2024
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34. Risk for Esophageal Cancer Based on Lifestyle Factors–Smoking, Alcohol Consumption, and Body Mass Index: Insight from a South Korean Population Study in a Low-Incidence Area

Author

Kwon, Mi Jung, primary, Kang, Ho Suk, additional, Choi, Hyo Geun, additional, Kim, Joo-Hee, additional, Kim, Ji Hee, additional, Bang, Woo Jin, additional, Hong, Sung Kwang, additional, Kim, Nan Young, additional, Hong, Sangkyoon, additional, and Lee, Hong Kyu, additional

Published
2023
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46. An elevated likelihood of stroke, ischemic heart disease, or heart failure in individuals with gout: a longitudinal follow-up study utilizing the National Health Information database in Korea

Author

Kang, Ho Suk, primary, Lee, Na-Eun, additional, Yoo, Dae Myoung, additional, Han, Kyeong Min, additional, Hong, Ji Yeon, additional, Choi, Hyo Geun, additional, Lim, Hyun, additional, Kim, Joo-Hee, additional, Kim, Ji Hee, additional, Cho, Seong-Jin, additional, Nam, Eun Sook, additional, Park, Ha Young, additional, Kim, Nan Young, additional, Baek, Sung Uk, additional, Lee, Joo Yeon, additional, and Kwon, Mi Jung, additional

Published
2023
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