35 results on '"Chiocchia, Virginia"'
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2. Semi-automated assessment of the risk of bias due to missing evidence in network meta-analysis: a guidance paper for the ROB-MEN web-application
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Chiocchia, Virginia, Holloway, Alexander, and Salanti, Georgia
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- 2023
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3. Trace amine-associated receptor 1 (TAAR1) agonism for psychosis: a living systematic review and meta-analysis of human and non-human data
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Siafis, Spyridon, primary, Chiocchia, Virginia, additional, Macleod, Malcolm R., additional, Austin, Charlotte, additional, Homiar, Ava, additional, Tinsdeall, Francesca, additional, Friedrich, Claire, additional, Ramage, Fiona J., additional, Kennett, Jaycee, additional, Nomura, Nobuyuki, additional, Maksym, Olena, additional, Rutigliano, Grazia, additional, Vano, Luke J., additional, McCutcheon, Robert A., additional, Gilbert, David, additional, Ostinelli, Edoardo G., additional, Stansfield, Claire, additional, Dehdarirad, Hossein, additional, Juma, Damian Omari, additional, Wright, Simonne, additional, Simple, Ouma, additional, Elugbadebo, Olufisayo, additional, Tonia, Thomy, additional, Mantas, Ioannis, additional, Howes, Oliver D., additional, Furukawa, Toshi A., additional, Milligan, Lea, additional, Moreno, Carmen, additional, Elliott, Julian H., additional, Hastings, Janna, additional, Thomas, James, additional, Michie, Susan, additional, Sena, Emily S., additional, Seedat, Soraya, additional, Egger, Matthias, additional, Potts, Jennifer, additional, Cipriani, Andrea, additional, Salanti, Georgia, additional, and Leucht, Stefan, additional
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- 2024
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4. Techniques to increase lumbar puncture success in newborn babies: the NeoCLEAR RCT
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Roehr, Charles C, primary, Marshall, Andrew SJ, additional, Scrivens, Alexandra, additional, Sadarangani, Manish, additional, Williams, Rachel, additional, Yong, Jean, additional, Linsell, Louise, additional, Chiocchia, Virginia, additional, Bell, Jennifer L, additional, Stokes, Caz, additional, Santhanadass, Patricia, additional, Nicoll, Ian, additional, Adams, Eleri, additional, King, Andrew, additional, Murray, David, additional, Bowler, Ursula, additional, Stanbury, Kayleigh, additional, and Juszczak, Edmund, additional
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- 2023
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5. HYDration and Bicarbonate to Prevent Acute Renal Injury After Endovascular Aneurysm Repair With Suprarenal Fixation: Pilot/Feasibility Randomised Controlled Study (HYDRA Pilot Trial)
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Saratzis, Athanasios, Chiocchia, Virginia, Jiffry, Ahmad, Hassanali, Neelam, Singh, Surjeet, Imray, Christopher H., Bown, Matthew J., and Mahmood, Asif
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- 2018
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6. New living evidence resource of human and non-human studies for early intervention and research prioritisation in anxiety, depression and psychosis
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Cipriani, Andrea, primary, Seedat, Soraya, additional, Milligan, Lea, additional, Salanti, Georgia, additional, Macleod, Malcolm, additional, Hastings, Janna, additional, Thomas, James, additional, Michie, Susan, additional, Furukawa, Toshi A, additional, Gilbert, David, additional, Soares-Weiser, Karla, additional, Moreno, Carmen, additional, Leucht, Stefan, additional, Egger, Matthias, additional, Mansoori, Parisa, additional, Barker, James M, additional, Siafis, Spyridon, additional, Ostinelli, Edoardo Giuseppe, additional, McCutcheon, Robert, additional, Wright, Simonne, additional, Simpson, Matilda, additional, Elugbadebo, Olufisayo, additional, Chiocchia, Virginia, additional, Tonia, Thomy, additional, Elgarf, Rania, additional, Kurtulmus, Ayse, additional, Sena, Emily, additional, Simple, Ouma, additional, Boyce, Niall, additional, Chung, Sophie, additional, Sharma, Anjuli, additional, Wolpert, Miranda, additional, Potts, Jennifer, additional, and Elliott, Julian H, additional
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- 2023
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7. Planned delivery or expectant management for late preterm pre-eclampsia: study protocol for a randomised controlled trial (PHOENIX trial)
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Chappell, Lucy C., Green, Marcus, Marlow, Neil, Sandall, Jane, Hunter, Rachael, Robson, Stephen, Bowler, Ursula, Chiocchia, Virginia, Hardy, Pollyanna, Juszczak, Edmund, Linsell, Louise, Placzek, Anna, Brocklehurst, Peter, and Shennan, Andrew
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- 2019
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8. New living evidence resource of human and non-human studies for early intervention and research prioritisation in anxiety, depression and psychosis [perspective]
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Cipriani, Andrea, Seedat, Soraya, Milligan, Lea, Salanti, Georgia, Macleod, Malcolm, Hastings, Janna, Thomas, James, Michie, Susan, Furukawa, Toshi A, Gilbert, David, Soares-Weiser, Karla, Moreno, Carmen, Leucht, Stefan, Egger, Matthias, Mansoori, Parisa, Barker, James M, Siafis, Spyridon, Ostinelli, Edoardo Giuseppe, McCutcheon, Robert, Wright, Simonne, Simpson, Matilda, Elugbadebo, Olufisayo, Chiocchia, Virginia, Tonia, Thomy, Elgarf, Rania, Kurtulmus, Ayse, Sena, Emily, Simple, Ouma, Boyce, Niall, Chung, Sophie, Sharma, Anjuli, Wolpert, Miranda, Potts, Jennifer, and Elliott, Julian H
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360 Social problems & social services ,610 Medicine & health - Abstract
In anxiety, depression and psychosis, there has been frustratingly slow progress in developing novel therapies that make a substantial difference in practice, as well as in predicting which treatments will work for whom and in what contexts. To intervene early in the process and deliver optimal care to patients, we need to understand the underlying mechanisms of mental health conditions, develop safe and effective interventions that target these mechanisms, and improve our capabilities in timely diagnosis and reliable prediction of symptom trajectories. Better synthesis of existing evidence is one way to reduce waste and improve efficiency in research towards these ends. Living systematic reviews produce rigorous, up-to-date and informative evidence summaries that are particularly important where research is emerging rapidly, current evidence is uncertain and new findings might change policy or practice. Global Alliance for Living Evidence on aNxiety, depressiOn and pSychosis (GALENOS) aims to tackle the challenges of mental health science research by cataloguing and evaluating the full spectrum of relevant scientific research including both human and preclinical studies. GALENOS will also allow the mental health community-including patients, carers, clinicians, researchers and funders-to better identify the research questions that most urgently need to be answered. By creating open-access datasets and outputs in a state-of-the-art online resource, GALENOS will help identify promising signals early in the research process. This will accelerate translation from discovery science into effective new interventions for anxiety, depression and psychosis, ready to be translated in clinical practice across the world.
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- 2023
9. A randomized trial of normothermic preservation in liver transplantation
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Nasralla, David, Coussios, Constantin C., Mergental, Hynek, Akhtar, M. Zeeshan, Butler, Andrew J., Ceresa, Carlo D. L., and Chiocchia, Virginia
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Liver transplantation -- Methods ,Aspartate ,Enzymes ,Surgery ,Organ transplantation ,Environmental issues ,Science and technology ,Zoology and wildlife conservation - Abstract
Liver transplantation is a highly successful treatment, but is severely limited by the shortage in donor organs. However, many potential donor organs cannot be used; this is because sub-optimal livers do not tolerate conventional cold storage and there is no reliable way to assess organ viability preoperatively. Normothermic machine perfusion maintains the liver in a physiological state, avoids cooling and allows recovery and functional testing. Here we show that, in a randomized trial with 220 liver transplantations, compared to conventional static cold storage, normothermic preservation is associated with a 50% lower level of graft injury, measured by hepatocellular enzyme release, despite a 50% lower rate of organ discard and a 54% longer mean preservation time. There was no significant difference in bile duct complications, graft survival or survival of the patient. If translated to clinical practice, these results would have a major impact on liver transplant outcomes and waiting list mortality.Normothermic machine perfusion of the liver improved early graft function, demonstrated by reduced peak serum aspartate transaminase levels and early allograft dysfunction rates, and improved organ utilization and preservation times, although no differences were seen in graft or patient survival., Author(s): David Nasralla [sup.1] , Constantin C. Coussios [sup.2] , Hynek Mergental [sup.3] , M. Zeeshan Akhtar [sup.1] [sup.4] , Andrew J. Butler [sup.5] , Carlo D. L. Ceresa [sup.1] [...]
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- 2018
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10. Metabolic side effects in persons with schizophrenia during mid‐ to long‐term treatment with antipsychotics: a network meta‐analysis of randomized controlled trials
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Burschinski, Angelika, primary, Schneider‐Thoma, Johannes, additional, Chiocchia, Virginia, additional, Schestag, Kristina, additional, Wang, Dongfang, additional, Siafis, Spyridon, additional, Bighelli, Irene, additional, Wu, Hui, additional, Hansen, Wulf‐Peter, additional, Priller, Josef, additional, Davis, John M., additional, Salanti, Georgia, additional, and Leucht, Stefan, additional
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- 2023
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11. Planned delivery for pre-eclampsia between 34 and 37 weeks of gestation: the PHOENIX RCT
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Chappell, Lucy C, primary, Brocklehurst, Peter, additional, Green, Marcus, additional, Hardy, Pollyanna, additional, Hunter, Rachael, additional, Beardmore-Gray, Alice, additional, Bowler, Ursula, additional, Brockbank, Anna, additional, Chiocchia, Virginia, additional, Cox, Alice, additional, Duhig, Kate, additional, Fleminger, Jessica, additional, Gill, Carolyn, additional, Greenland, Melanie, additional, Hendy, Eleanor, additional, Kennedy, Ann, additional, Leeson, Paul, additional, Linsell, Louise, additional, McCarthy, Fergus P, additional, O’Driscoll, Jamie, additional, Placzek, Anna, additional, Poston, Lucilla, additional, Robson, Stephen, additional, Rushby, Pauline, additional, Sandall, Jane, additional, Scholtz, Laura, additional, Seed, Paul T, additional, Sparkes, Jenie, additional, Stanbury, Kayleigh, additional, Tohill, Sue, additional, Thilaganathan, Basky, additional, Townend, John, additional, Juszczak, Edmund, additional, Marlow, Neil, additional, and Shennan, Andrew, additional
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- 2022
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12. ROB-MEN: a tool to assess risk of bias due to missing evidence in network meta-analysis
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Chiocchia, Virginia, Nikolakopoulou, Adriani, Higgins, Julian P T, Page, Matthew J, Papakonstantinou, Theodoros, Cipriani, Andrea, Furukawa, Toshi A, Siontis, George C.M., Egger, Matthias, Salanti, Georgia, Centre for Infectious Disease Epidemiology and Research (CIDER), and Faculty of Health Sciences
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Adult ,Depressive Disorder, Major ,360 Soziale Probleme, Sozialdienste ,610 Medicine & health ,Guideline ,Publication bias ,Risk Assessment ,Risk of bias ,360 Social problems & social services ,Evidence synthesis ,Selective outcome reporting ,Reporting bias ,Humans ,Medicine ,Missing evidence ,610 Medizin und Gesundheit ,Network meta-analysis - Abstract
Background Selective outcome reporting and publication bias threaten the validity of systematic reviews and meta-analyses and can affect clinical decision-making. A rigorous method to evaluate the impact of this bias on the results of network meta-analyses of interventions is lacking. We present a tool to assess the Risk Of Bias due to Missing Evidence in Network meta-analysis (ROB-MEN). Methods ROB-MEN first evaluates the risk of bias due to missing evidence for each of the possible pairwise comparison that can be made between the interventions in the network. This step considers possible bias due to the presence of studies with unavailable results (within-study assessment of bias) and the potential for unpublished studies (across-study assessment of bias). The second step combines the judgements about the risk of bias due to missing evidence in pairwise comparisons with (i) the contribution of direct comparisons to the network meta-analysis estimates, (ii) possible small-study effects evaluated by network meta-regression, and (iii) any bias from unobserved comparisons. Then, a level of “low risk”, “some concerns”, or “high risk” for the bias due to missing evidence is assigned to each estimate, which is our tool’s final output. Results We describe the methodology of ROB-MEN step-by-step using an illustrative example from a published NMA of non-diagnostic modalities for the detection of coronary artery disease in patients with low risk acute coronary syndrome. We also report a full application of the tool on a larger and more complex published network of 18 drugs from head-to-head studies for the acute treatment of adults with major depressive disorder. Conclusions ROB-MEN is the first tool for evaluating the risk of bias due to missing evidence in network meta-analysis and applies to networks of all sizes and geometry. The use of ROB-MEN is facilitated by an R Shiny web application that produces the Pairwise Comparisons and ROB-MEN Table and is incorporated in the reporting bias domain of the CINeMA framework and software.
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- 2021
13. Special Session 4: Quantitative synthesis - NMA livestream
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Keenan, Ciara, Metelli, Silvia, Chiocchia, Virginia, Nevill, Clareece, and Hamza, Tasnim
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meta-analysis ,ESMARConf2022 ,evidence synthesis ,RStats - Abstract
Moderator: Ciara Keenan Session: Special Session 4: Quantitative synthesis - NMA livestream
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- 2022
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14. Additional file 6 of ROB-MEN: a tool to assess risk of bias due to missing evidence in network meta-analysis
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Chiocchia, Virginia, Nikolakopoulou, Adriani, Higgins, Julian P. T., Page, Matthew J., Papakonstantinou, Theodoros, Cipriani, Andrea, Furukawa, Toshi A., Siontis, George C. M., Egger, Matthias, and Salanti, Georgia
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Additional file 6. Contribution matrix for the network of non-invasive diagnostic modalities for coronary artery disease in patients with low risk acute coronary syndrome.
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- 2021
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15. Additional file 3 of ROB-MEN: a tool to assess risk of bias due to missing evidence in network meta-analysis
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Chiocchia, Virginia, Nikolakopoulou, Adriani, Higgins, Julian P. T., Page, Matthew J., Papakonstantinou, Theodoros, Cipriani, Andrea, Furukawa, Toshi A., Siontis, George C. M., Egger, Matthias, and Salanti, Georgia
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ComputingMilieux_GENERAL ,ComputingMilieux_THECOMPUTINGPROFESSION ,Data_FILES ,ComputerSystemsOrganization_PROCESSORARCHITECTURES ,Hardware_REGISTER-TRANSFER-LEVELIMPLEMENTATION - Abstract
Additional file 3. Instructions for filling in the ROB-MEN Table.
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- 2021
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16. Additional file 4 of ROB-MEN: a tool to assess risk of bias due to missing evidence in network meta-analysis
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Chiocchia, Virginia, Nikolakopoulou, Adriani, Higgins, Julian P. T., Page, Matthew J., Papakonstantinou, Theodoros, Cipriani, Andrea, Furukawa, Toshi A., Siontis, George C. M., Egger, Matthias, and Salanti, Georgia
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psychological phenomena and processes - Abstract
Additional file 4. Description of the judgements from the across-study assessment of bias for the example of non-invasive diagnostic modalities for detection of coronary artery disease in patients with low risk acute coronary syndromes.
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- 2021
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17. Additional file 7 of ROB-MEN: a tool to assess risk of bias due to missing evidence in network meta-analysis
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Chiocchia, Virginia, Nikolakopoulou, Adriani, Higgins, Julian P. T., Page, Matthew J., Papakonstantinou, Theodoros, Cipriani, Andrea, Furukawa, Toshi A., Siontis, George C. M., Egger, Matthias, and Salanti, Georgia
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Additional file 7. Pairwise Comparisons Table for the network of 18 antidepressants.
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- 2021
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18. Additional file 5 of ROB-MEN: a tool to assess risk of bias due to missing evidence in network meta-analysis
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Chiocchia, Virginia, Nikolakopoulou, Adriani, Higgins, Julian P. T., Page, Matthew J., Papakonstantinou, Theodoros, Cipriani, Andrea, Furukawa, Toshi A., Siontis, George C. M., Egger, Matthias, and Salanti, Georgia
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Additional file 5. Flow chart for assessing overall risk of bias due to missing evidence in pairwise comparisons.
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- 2021
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19. Additional file 1 of ROB-MEN: a tool to assess risk of bias due to missing evidence in network meta-analysis
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Chiocchia, Virginia, Nikolakopoulou, Adriani, Higgins, Julian P. T., Page, Matthew J., Papakonstantinou, Theodoros, Cipriani, Andrea, Furukawa, Toshi A., Siontis, George C. M., Egger, Matthias, and Salanti, Georgia
- Abstract
Additional file 1. Network graph, methods and forest plot for the network meta-analysis of non-invasive diagnostic modalities for the detection of coronary artery disease in patients with low risk acute coronary syndromes.
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- 2021
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20. Additional file 2 of ROB-MEN: a tool to assess risk of bias due to missing evidence in network meta-analysis
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Chiocchia, Virginia, Nikolakopoulou, Adriani, Higgins, Julian P. T., Page, Matthew J., Papakonstantinou, Theodoros, Cipriani, Andrea, Furukawa, Toshi A., Siontis, George C. M., Egger, Matthias, and Salanti, Georgia
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ComputingMethodologies_PATTERNRECOGNITION ,TheoryofComputation_ANALYSISOFALGORITHMSANDPROBLEMCOMPLEXITY ,Data_FILES ,Hardware_CONTROLSTRUCTURESANDMICROPROGRAMMING ,MathematicsofComputing_DISCRETEMATHEMATICS - Abstract
Additional file 2. Instructions for filling in the Pairwise Comparisons Table.
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- 2021
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21. Additional file 8 of ROB-MEN: a tool to assess risk of bias due to missing evidence in network meta-analysis
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Chiocchia, Virginia, Nikolakopoulou, Adriani, Higgins, Julian P. T., Page, Matthew J., Papakonstantinou, Theodoros, Cipriani, Andrea, Furukawa, Toshi A., Siontis, George C. M., Egger, Matthias, and Salanti, Georgia
- Abstract
Additional file 8. ROB-MEN Table for the network of 18 antidepressants.
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- 2021
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22. Additional file 1 of Study protocol: NeoCLEAR: Neonatal Champagne Lumbar punctures Every time – An RCT: a multicentre, randomised controlled 2 × 2 factorial trial to investigate techniques to increase lumbar puncture success
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Marshall, Andrew S. J., Sadarangani, Manish, Scrivens, Alexandra, Williams, Rachel, Yong, Jean, Bowler, Ursula, Linsell, Louise, Chiocchia, Virginia, Bell, Jennifer L., Caz Stokes, Santhanadass, Patricia, Adams, Eleri, Juszczak, Edmund, and Roehr, Charles C.
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Additional file 1. Supplementary appendix: List of tested and untested outcomes.
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- 2020
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23. Agreement between ranking metrics in network meta-analysis: an empirical study
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Chiocchia, Virginia, primary, Nikolakopoulou, Adriani, additional, Papakonstantinou, Theodoros, additional, Egger, Matthias, additional, and Salanti, Georgia, additional
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- 2020
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24. Intravenous co-amoxiclav to prevent infection after operative vaginal delivery: the ANODE RCT
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Knight, Marian, primary, Chiocchia, Virginia, additional, Partlett, Christopher, additional, Rivero-Arias, Oliver, additional, Hua, Xinyang, additional, Bowler, Ursula, additional, Gray, James, additional, Gray, Shan, additional, Hinshaw, Kim, additional, Khunda, Aethele, additional, Moore, Philip, additional, Mottram, Linda, additional, Owino, Nelly, additional, Pasupathy, Dharmintra, additional, Sanders, Julia, additional, Sultan, Abdul H, additional, Thakar, Ranee, additional, Tuffnell, Derek, additional, Linsell, Louise, additional, and Juszczak, Edmund, additional
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- 2019
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25. Additional file 3: of Planned delivery or expectant management for late preterm pre-eclampsia: study protocol for a randomised controlled trial (PHOENIX trial)
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Chappell, Lucy, Green, Marcus, Marlow, Neil, Sandall, Jane, Hunter, Rachael, Robson, Stephen, Bowler, Ursula, Chiocchia, Virginia, Pollyanna Hardy, Juszczak, Edmund, Linsell, Louise, Placzek, Anna, Brocklehurst, Peter, and Shennan, Andrew
- Abstract
Statistical analysis plan. (DOCX 187 kb)
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- 2019
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26. Additional file 2: of Planned delivery or expectant management for late preterm pre-eclampsia: study protocol for a randomised controlled trial (PHOENIX trial)
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Chappell, Lucy, Green, Marcus, Marlow, Neil, Sandall, Jane, Hunter, Rachael, Robson, Stephen, Bowler, Ursula, Chiocchia, Virginia, Pollyanna Hardy, Juszczak, Edmund, Linsell, Louise, Placzek, Anna, Brocklehurst, Peter, and Shennan, Andrew
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Consent form. (PDF 238 kb)
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- 2019
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27. Additional file 1: of Planned delivery or expectant management for late preterm pre-eclampsia: study protocol for a randomised controlled trial (PHOENIX trial)
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Chappell, Lucy, Green, Marcus, Marlow, Neil, Sandall, Jane, Hunter, Rachael, Robson, Stephen, Bowler, Ursula, Chiocchia, Virginia, Pollyanna Hardy, Juszczak, Edmund, Linsell, Louise, Placzek, Anna, Brocklehurst, Peter, and Shennan, Andrew
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body regions ,nervous system ,fungi ,cardiovascular system ,lipids (amino acids, peptides, and proteins) - Abstract
Participant information leaflet. (PDF 1587 kb)
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- 2019
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28. Additional file 4: of Planned delivery or expectant management for late preterm pre-eclampsia: study protocol for a randomised controlled trial (PHOENIX trial)
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Chappell, Lucy, Green, Marcus, Marlow, Neil, Sandall, Jane, Hunter, Rachael, Robson, Stephen, Bowler, Ursula, Chiocchia, Virginia, Pollyanna Hardy, Juszczak, Edmund, Linsell, Louise, Placzek, Anna, Brocklehurst, Peter, and Shennan, Andrew
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SPIRIT 2013 Checklist: Recommended items to address in a clinical trial protocol and related documents. (DOC 121 kb)
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- 2019
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29. Very low-dose dexamethasone to facilitate extubation of preterm babies at risk of bronchopulmonary dysplasia: the MINIDEX feasibility RCT
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Yates, Helen, primary, Chiocchia, Virginia, additional, Linsell, Louise, additional, Orsi, Nicolas, additional, Juszczak, Edmund, additional, Johnson, Kathryn, additional, Chetcuti, Philip, additional, Illingworth, Claire, additional, Hardy, Pollyanna, additional, Monk, Vaneesha, additional, Newell, Simon, additional, and Turner, Mark, additional
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- 2019
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30. Methods for Evaluating Medical Tests and Biomarkers
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Gopalakrishna, Gowri, Langendam, Miranda, Scholten, Rob, Bossuyt, Patrick, Leeflang, Mariska, Noel-Storr, Anna, Thomas, James, Marshall, Iain, Wallace, Byron, Whiting, Penny, Davenport, Clare, GopalaKrishna, Gowri, de Salis, Isabel, Mallett, Sue, Wolff, Robert, Riley, Richard, Westwood, Marie, Kleinen, Jos, Collins, Gary, Reitsma, Hans, Moons, Karel, Zapf, Antonia, Hoyer, Annika, Kramer, Katharina, Kuss, Oliver, Ensor, J., Deeks, J. J., Martin, E. C., Riley, R. D., Rücker, Gerta, Steinhauser, Susanne, Schumacher, Martin, Ensor, Joie, Snell, Kym, Willis, Brian, Debray, Thomas, Deeks, Jon, di Ruffano, Lavinia Ferrante, Taylor-Phillips, Sian, Hyde, Chris, Taylor, Stuart A., Batnagar, Gauraang, Di Ruffano, Lavinia Ferrante, Seedat, Farah, Clarke, Aileen, Byron, Sarah, Nixon, Frances, Albrow, Rebecca, Walker, Thomas, Deakin, Carla, Zhelev, Zhivko, Hunt, Harriet, Yang, Yaling, Abel, Lucy, Buchanan, James, Fanshawe, Thomas, Shinkins, Bethany, Wynants, Laure, Verbakel, Jan, Van Huffel, Sabine, Timmerman, Dirk, Van Calster, Ben, Zwinderman, Aeliko, Oke, Jason, O’Sullivan, Jack, Perera, Rafael, Nicholson, Brian, Bromley, Hannah L., Roberts, Tracy E., Francis, Adele, Petrie, Denniis, Mann, G. Bruce, Malottki, Kinga, Smith, Holly, Billingham, Lucinda, Sitch, Alice, Gerke, Oke, Holm-Vilstrup, Mie, Segtnan, Eivind Antonsen, Halekoh, Ulrich, Høilund-Carlsen, Poul Flemming, Francq, Bernard G., Dinnes, Jac, Parkes, Julie, Gregory, Walter, Hewison, Jenny, Altman, Doug, Rosenberg, William, Selby, Peter, Asselineau, Julien, Perez, Paul, Paye, Aïssatou, Bessede, Emilie, Proust-Lima, Cécile, Naaktgeboren, Christiana, de Groot, Joris, Rutjes, Anne, Reitsma, Johannes, Ogundimu, Emmanuel, Cook, Jonathan, Le Manach, Yannick, Vergouwe, Yvonne, Pajouheshnia, Romin, Groenwold, Rolf, Moons, Karen, Peelen, Linda, Nieboer, Daan, De Cock, Bavo, Pencina, Micael J., Steyerberg, Ewout W., Cooper, Jennifer, Parsons, Nick, Stinton, Chris, Smith, Steve, Dickens, Andy, Jordan, Rachel, Enocson, Alexandra, Fitzmaurice, David, Adab, Peymane, Boachie, Charles, Vidmar, Gaj, Freeman, Karoline, Connock, Martin, Court, Rachel, Moons, Carl, Harris, Jessica, Mumford, Andrew, Plummer, Zoe, Lee, Kurtis, Reeves, Barnaby, Rogers, Chris, Verheyden, Veerle, Angelini, Gianni D., Murphy, Gavin J., Huddy, Jeremy, Ni, Melody, Good, Katherine, Cooke, Graham, Hanna, George, Ma, Jie, Moons, K. G. M. (Carl), de Groot, Joris A. H., Altman, Doug G., Reitsma, Johannes B., Collins, Gary S., Moons, Karel G. M., Altman, Douglas G., Kamarudin, Adina Najwa, Kolamunnage-Dona, Ruwanthi, Cox, Trevor, Borsci, Simone, Pérez, Teresa, Pardo, M.Carmen, Candela-Toha, Angel, Muriel, Alfonso, Zamora, Javier, Sanghera, Sabina, Mohiuddin, Syed, Martin, Richard, Donovan, Jenny, Coast, Joanna, Seo, Mikyung Kelly, Cairns, John, Mitchell, Elizabeth, Smith, Alison, Wright, Judy, Hall, Peter, Messenger, Michael, Calder, Nicola, Wickramasekera, Nyantara, Vinall-Collier, Karen, Lewington, Andrew, Damen, Johanna, Cairns, David, Hutchinson, Michelle, Sturgeon, Cathie, Mitchel, Liz, Kift, Rebecca, Christakoudi, Sofia, Rungall, Manohursingh, Mobillo, Paula, Montero, Rosa, Tsui, Tjir-Li, Kon, Sui Phin, Tucker, Beatriz, Sacks, Steven, Farmer, Chris, Strom, Terry, Chowdhury, Paramit, Rebollo-Mesa, Irene, Hernandez-Fuentes, Maria, Damen, Johanna A. A. G., Debray, Thomas P. A., Heus, Pauline, Hooft, Lotty, Scholten, Rob J. P. M., Schuit, Ewoud, Tzoulaki, Ioanna, Lassale, Camille M., Siontis, George C. M., Chiocchia, Virginia, Roberts, Corran, Schlüssel, Michael Maia, Gerry, Stephen, Black, James A., van der Schouw, Yvonne T., Peelen, Linda M., Spence, Graeme, McCartney, David, van den Bruel, Ann, Lasserson, Daniel, Hayward, Gail, Vach, Werner, de Jong, Antoinette, Burggraaff, Coreline, Hoekstra, Otto, Zijlstra, Josée, de Vet, Henrica, Graziadio, Sara, Allen, Joy, Johnston, Louise, O’Leary, Rachel, Power, Michael, Johnson, Louise, Waters, Ray, Simpson, John, Fanshawe, Thomas R., Phillips, Peter, Plumb, Andrew, Helbren, Emma, Halligan, Steve, Gale, Alastair, Sekula, Peggy, Sauerbrei, Willi, Forman, Julia R., Dutton, Susan J., Takwoingi, Yemisi, Hensor, Elizabeth M., Nichols, Thomas E., Kempf, Emmanuelle, Porcher, Raphael, de Beyer, Jennifer, Altman, Douglas, Hopewell, Sally, Dennis, John, Shields, Beverley, Jones, Angus, Henley, William, Pearson, Ewan, Hattersley, Andrew, Scheibler, Fueloep, Rummer, Anne, Sturtz, Sibylle, Großelfinger, Robert, Banister, Katie, Ramsay, Craig, Azuara-Blanco, Augusto, Burr, Jennifer, Kumarasamy, Manjula, Bourne, Rupert, Uchegbu, Ijeoma, Murphy, Jennifer, Carter, Alex, Murphy, Jen, Marti, Joachim, Eatock, Julie, Robotham, Julie, Dudareva, Maria, Gilchrist, Mark, Holmes, Alison, Monaghan, Phillip, Lord, Sarah, StJohn, Andrew, Sandberg, Sverre, Cobbaert, Christa, Lennartz, Lieselotte, Verhagen-Kamerbeek, Wilma, Ebert, Christoph, Horvath, Andrea, Jenniskens, Kevin, Peters, Jaime, Grigore, Bogdan, Ukoumunne, Obi, Levis, Brooke, Benedetti, Andrea, Levis, Alexander W., Ioannidis, John P. A., Shrier, Ian, Cuijpers, Pim, Gilbody, Simon, Kloda, Lorie A., McMillan, Dean, Patten, Scott B, Steele, Russell J., Ziegelstein, Roy C, Bombardier, Charles H., Osório, Flavia de Lima, Fann, Jesse R., Gjerdingen, Dwenda, Lamers, Femke, Lotrakul, Manote, Loureiro, Sonia R, Löwe, Bernd, Shaaban, Juwita, Stafford, Lesley, van Weert, Henk C. P. M., Whooley, Mary A., Williams, Linda S., Wittkampf, Karin A., Yeung, Albert S., Thombs, Brett D., Cooper, Chris, Nieto, Tom, Smith, Claire, Tucker, Olga, Dretzke, Janine, Beggs, Andrew, Rai, Nirmala, Bayliss, Sue, Stevens, Simon, Mallet, Sue, Sundar, Sudha, Hall, Emma, Porta, Nuria, Estelles, David Lorente, and de Bono, Johann
- Subjects
Faecal Immunochemical Test ,Chronic Obstructive Pulmonary Disorder ,Circulate Tumour Cell Count ,Apply Health Research ,Meeting Abstracts ,Faecal Immunochemical Test Result - Abstract
unKnown
- Published
- 2017
31. Study protocol: NeoCLEAR: Neonatal Champagne Lumbar punctures Every time - An RCT: a multicentre, randomised controlled 2 × 2 factorial trial to investigate techniques to increase lumbar puncture success.
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Marshall, Andrew S. J., Sadarangani, Manish, Scrivens, Alexandra, Williams, Rachel, Yong, Jean, Bowler, Ursula, Linsell, Louise, Chiocchia, Virginia, Bell, Jennifer L., Stokes, Caz, Santhanadass, Patricia, Adams, Eleri, Juszczak, Edmund, Roehr, Charles C., and ‘The NeoCLEAR Collaborative Group’
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LUMBAR puncture ,BACTERIAL meningitis ,DRUG resistance in bacteria ,MEDICAL care costs ,HOSPITAL maternity services ,SITTING position - Abstract
Background: The neonatal period carries the highest risk of bacterial meningitis (~ 1 in 5000 births), bearing high mortality (~ 10%) and morbidity (20-50%) rates. Lumbar puncture (LP) remains essential to the diagnosis of meningitis. Though LP is a common procedure in neonates, success rates are lower (50-60%) than in other patient populations. None of the currently-practised neonatal LP techniques are supported by evidence from adequately-powered, randomised controlled trials (RCTs). NeoCLEAR aims to compare two modifications to the traditional technique which are free, accessible, and commonly practised: sitting (as opposed to lying) position, and 'early' (as opposed to 'late') stylet removal.Methods/design: Written parental informed consent permitting, infants in neonatal/maternity wards, of 27+ 0 to 44+ 0 weeks corrected gestational age and weighing ≥1000 g, who require an LP, will be randomly allocated to sitting or lying position, and to early or late stylet removal. The co-primary objectives are to compare success rates (the proportion of infants with cerebrospinal fluid red cell count < 10,000/mm3 on first LP procedure) in 1020 infants between the two positions, and between the two methods of stylet removal. Secondary outcomes relate to LP procedures, complications, diagnoses of meningitis, duration of antibiotics and hospital stay. A modified intention-to-treat analysis will be conducted.Discussion: Two modifications to the traditional LP technique (sitting vs lying position; and early vs late stylet removal) will be simultaneously investigated in an efficient and appropriately-powered 2 × 2 factorial RCT design. Analysis will identify the optimal techniques (in terms of obtaining easily-interpretable cerebrospinal fluid), as well as the impact on infants, parents and healthcare systems whilst providing robust safety data. Using a pragmatic RCT design, all practitioners will be trained in all LP techniques, but there will inevitably be variation between unit practice guidelines and other aspects of individual care. An improved LP technique would result in: • Fewer uninterpretable samples, repeated attempts and procedures • Reduced distress for infants and families • Decreased antibiotic use and risk of antibiotic resistance • Reduced healthcare costs due to fewer procedures, reduced length of stay, shorter antibiotic courses, and minimised antibiotic-associated complications TRIAL REGISTRATION: ISRCTN14040914. Date assigned: 26/06/2018. [ABSTRACT FROM AUTHOR]- Published
- 2020
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32. Impact of a web-based tool (WebCONSORT) to improve the reporting of randomised trials: results of a randomised controlled trial
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Hopewell, Sally, primary, Boutron, Isabelle, additional, Altman, Douglas G., additional, Barbour, Ginny, additional, Moher, David, additional, Montori, Victor, additional, Schriger, David, additional, Cook, Jonathan, additional, Gerry, Stephen, additional, Omar, Omar, additional, Dutton, Peter, additional, Roberts, Corran, additional, Frangou, Eleni, additional, Clifton, Lei, additional, Chiocchia, Virginia, additional, Rombach, Ines, additional, Wartolowska, Karolina, additional, and Ravaud, Philippe, additional
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- 2016
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33. Pro-dopaminergic pharmacological interventions for anhedonia in depression: protocol for a living systematic review of human and non-human studies.
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Ostinelli EG, Chiocchia V, Macleod M, Browning M, Harmer C, Siafis S, Stansfield C, Friedrich C, Wright S, Chikaura T, Milligan L, Thomas J, Moreno C, Furukawa TA, Seedat S, Potts J, Salanti G, and Cipriani A
- Abstract
Background: Anhedonia is a key symptom of depression, and it has been suggested as a potential target for future individualised treatments. However, much is unknown about how interventions enhancing dopaminergic pathways may affect anhedonia symptoms in the context of depression. Methods: We will perform independent searches in multiple electronic databases to identify clinical and animal experimental studies on pro-dopaminergic interventions in individuals with depression or animal models for depression. The primary outcomes will be overall anhedonia symptoms and their behavioural proxies in animals. Secondary outcomes will include side effects and neurobiological measures. At least two independent reviewers will conduct the study selection, data extraction, and risk of bias assessments using pre-defined tools according to each record's study design. We will develop ontologies to facilitate study identification and data extraction. We will synthesise data from clinical and animal studies separately. If appropriate, we will use random-effects meta-analyses, or synthesis without meta-analyses. We will investigate study characteristics as potential sources of heterogeneity. We will evaluate the confidence in the evidence for each outcome and source of evidence, considering the summary of the association, potential concerns regarding internal and external validity, and reporting biases. When multiple sources of evidence are available for an outcome, we will draw an overall conclusion in a triangulation meeting involving a multidisciplinary team of experts. We plan updates of the review every 6 months, and any future modifications to the protocol will be documented. We will co-produce this review with multiple stakeholders. PROSPERO registration: CRD42023451821., Competing Interests: Competing interests: Edoardo G. Ostinelli received research and consultancy fees from Angelini Pharma. Carmen Moreno received honoraria as a consultant and/or advisor and/or for lectures from Angelini, Compass, Esteve, Exeltis Janssen, Lundbeck, Neuraxpharm, Nuvelution, Otsuka, Pfizer, Servier and Sunovion outside the submitted work. Toshi A Furukawa received personal fees from Boehringer- Ingelheim, DT Axis, Kyoto University Original, Shionogi, and SONY, and a grant from Shionogi outside the submitted work; in addition, TAF has patents 2020-548587 and 2022-082495 pending, and intellectual properties for Kokoro-app licensed to Mitsubishi-Tanabe. Andrea Cipriani received research, educational and consultancy fees from the Italian Network for Paediatric Trials, CARIPLO Foundation, Lundbeck, and Angelini Pharma., (Copyright: © 2023 Ostinelli EG et al.)
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- 2023
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34. Trace amine-associated receptor 1 (TAAR1) agonists for psychosis: protocol for a living systematic review and meta-analysis of human and non-human studies.
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Siafis S, McCutcheon R, Chiocchia V, Ostinelli EG, Wright S, Stansfield C, Juma DO, Mantas I, Howes OD, Rutigliano G, Ramage F, Tinsdeall F, Friedrich C, Milligan L, Moreno C, Elliott JH, Thomas J, Macleod MR, Sena ES, Seedat S, Salanti G, Potts J, Cipriani A, and Leucht S
- Abstract
Background: There is an urgent need to develop more effective and safer antipsychotics beyond dopamine 2 receptor antagonists. An emerging and promising approach is TAAR1 agonism. Therefore, we will conduct a living systematic review and meta-analysis to synthesize and triangulate the evidence from preclinical animal experiments and clinical studies on the efficacy, safety, and underlying mechanism of action of TAAR1 agonism for psychosis., Methods: Independent searches will be conducted in multiple electronic databases to identify clinical and animal experimental studies comparing TAAR1 agonists with licensed antipsychotics or other control conditions in individuals with psychosis or animal models for psychosis, respectively. The primary outcomes will be overall psychotic symptoms and their behavioural proxies in animals. Secondary outcomes will include side effects and neurobiological measures. Two independent reviewers will conduct study selection, data extraction using predefined forms, and risk of bias assessment using suitable tools based on the study design. Ontologies will be developed to facilitate study identification and data extraction. Data from clinical and animal studies will be synthesized separately using random-effects meta-analysis if appropriate, or synthesis without meta-analysis. Study characteristics will be investigated as potential sources of heterogeneity. Confidence in the evidence for each outcome and source of evidence will be evaluated, considering the summary of the association, potential concerns regarding internal and external validity, and reporting biases. When multiple sources of evidence are available for an outcome, an overall conclusion will be drawn in a triangulation meeting involving a multidisciplinary team of experts. We plan trimonthly updates of the review, and any modifications in the protocol will be documented. The review will be co-produced by multiple stakeholders aiming to produce impactful and relevant results and bridge the gap between preclinical and clinical research on psychosis., Protocol Registration: PROSPERO-ID: CRD42023451628., Competing Interests: Competing interests: Spyridon Siafis: None Robert McCutcheon: RM received speaker/consultancy fees from Karuna, Janssen, Boehringer Ingelheim and Otsuka, and is director of a company that hosts psychotropic prescribing decision tools. Virginia Chiocchia: None. Edoardo G. Ostinelli: EGO has received research and consultancy fees from Angelini Pharma. Simonne Wright: None. Claire Stansfield: None. Damian Omari Juma: None. Ioannis Mantas: None. Oliver D. Howes: ODH is a part-time employee of H. Lundbeck A/S and has received investigator-initiated research funding from and/or participated in advisory/speaker meetings organized by Angellini, Autifony, Biogen, Boehringer-Ingelheim, Eli Lilly, Heptares, Global Medical Education, Invicro, Jansenn, Lundbeck, Neurocrine, Otsuka, Sunovion, Rand, Recordati, Roche and Viatris/Mylan. Neither Howes or his family have holdings/a financial stake in any pharmaceutical company Grazia Rutigliano: None. Fiona Ramage: None. Francesca Tinsdeall: None. Claire Friedrich: None. Lea Milligan: None. Carmen Moreno: CM received honoraria as a consultant and/or advisor and/or for lectures from Angelini, Compass, Esteve, Exeltis Janssen, Lundbeck, Neuraxpharm, Nuvelution, Otsuka, Pfizer, Servier and Sunovion outside the submitted work. Julian H Elliott: None. James Thomas: None. Emily Sena: None. Malcolm R. MacLeod: None. Soraya Seedat: None Georgia Salanti: None. Jennifer Potts: None. Andrea Cipriani: AC received research, educational and consultancy fees from the Italian Network for Paediatric Trials, CARIPLO Foundation, Lundbeck, and Angelini Pharma. Stefan Leucht: SL has received honoraria as advisor and/or for lectures and/or for educational material from Alkermes, Angelini, Apsen, Eisai, Gedeon Richter, Janssen, Karuna, Kynexis, Lundbeck, Medichem, Medscape, Merck Sharpp and Dome, Mitshubishi, Neurotorium, NovoNordisk, Otsuka, Recordati, Roche, Rovi, Sanofi Aventis, TEVA, (Copyright: © 2023 Siafis S et al.)
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- 2023
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35. Erratum to: Methods for evaluating medical tests and biomarkers.
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Gopalakrishna G, Langendam M, Scholten R, Bossuyt P, Leeflang M, Noel-Storr A, Thomas J, Marshall I, Wallace B, Whiting P, Davenport C, Leeflang M, GopalaKrishna G, de Salis I, Mallett S, Wolff R, Whiting P, Riley R, Westwood M, Kleinen J, Collins G, Reitsma H, Moons K, Zapf A, Hoyer A, Kramer K, Kuss O, Ensor J, Deeks JJ, Martin EC, Riley RD, Rücker G, Steinhauser S, Schumacher M, Riley R, Ensor J, Snell K, Willis B, Debray T, Moons K, Deeks J, Collins G, di Ruffano LF, Willis B, Davenport C, Mallett S, Taylor-Phillips S, Hyde C, Deeks J, Mallett S, Taylor SA, Batnagar G, Taylor-Phillips S, Di Ruffano LF, Seedat F, Clarke A, Deeks J, Byron S, Nixon F, Albrow R, Walker T, Deakin C, Hyde C, Zhelev Z, Hunt H, di Ruffano LF, Yang Y, Abel L, Buchanan J, Fanshawe T, Shinkins B, Wynants L, Verbakel J, Van Huffel S, Timmerman D, Van Calster B, Leeflang M, Zwinderman A, Bossuyt P, Oke J, O'Sullivan J, Perera R, Nicholson B, Bromley HL, Roberts TE, Francis A, Petrie D, Mann GB, Malottki K, Smith H, Deeks J, Billingham L, Sitch A, Mallett S, Deeks J, Gerke O, Holm-Vilstrup M, Segtnan EA, Halekoh U, Høilund-Carlsen PF, Francq BG, Deeks J, Sitch A, Dinnes J, Parkes J, Gregory W, Hewison J, Altman D, Rosenberg W, Selby P, Asselineau J, Perez P, Paye A, Bessede E, Proust-Lima C, Naaktgeboren C, de Groot J, Rutjes A, Bossuyt P, Reitsma J, Moons K, Collins G, Ogundimu E, Cook J, Le Manach Y, Altman D, Wynants L, Vergouwe Y, Van Huffel S, Timmerman D, Van Calster B, Pajouheshnia R, Groenwold R, Moons K, Reitsma J, Peelen L, Van Calster B, Nieboer D, Vergouwe Y, De Cock B, Pencina MJ, Steyerberg EW, Cooper J, Taylor-Phillips S, Parsons N, Stinton C, Smith S, Dickens A, Jordan R, Enocson A, Fitzmaurice D, Sitch A, Adab P, Francq BG, Boachie C, Vidmar G, Freeman K, Connock M, Taylor-Phillips S, Court R, Clarke A, de Groot J, Naaktgeboren C, Reitsma H, Moons C, Harris J, Mumford A, Plummer Z, Lee K, Reeves B, Rogers C, Verheyden V, Angelini GD, Murphy GJ, Huddy J, Ni M, Good K, Cooke G, Bossuyt P, Hanna G, Ma J, Altman D, Collins G, Moons KGMC, de Groot JAH, Mallett S, Altman DG, Reitsma JB, Collins GS, Moons KGM, Altman DG, Reitsma JB, Collins GS, Kamarudin AN, Kolamunnage-Dona R, Cox T, Ni M, Huddy J, Borsci S, Hanna G, Pérez T, Pardo MC, Candela-Toha A, Muriel A, Zamora J, Sanghera S, Mohiuddin S, Martin R, Donovan J, Coast J, Seo MK, Cairns J, Mitchell E, Smith A, Wright J, Hall P, Messenger M, Calder N, Wickramasekera N, Vinall-Collier K, Lewington A, Pajouheshnia R, Damen J, Groenwold R, Moons K, Peelen L, Messenger M, Cairns D, Smith A, Hutchinson M, Wright J, Hall P, Calder N, Sturgeon C, Mitchel L, Kift R, Christakoudi S, Rungall M, Mobillo P, Montero R, Tsui TL, Kon SP, Tucker B, Sacks S, Farmer C, Strom T, Chowdhury P, Rebollo-Mesa I, Hernandez-Fuentes M, Damen JAAG, Debray TPA, Heus P, Hooft L, Moons KGM, Pajouheshnia R, Reitsma JB, Scholten RJPM, Damen JAAG, Hooft L, Schuit E, Debray TPA, Collins GS, Tzoulaki I, Lassale CM, Siontis GCM, Chiocchia V, Roberts C, Schlüssel MM, Gerry S, Black JA, Heus P, van der Schouw YT, Peelen LM, Moons KGM, Damen JAAG, Debray TPA, Heus P, Hooft L, Moons KGM, Pajouheshnia R, Reitsma JB, Scholten RJPM, Ma J, Altman D, Collins G, Spence G, McCartney D, van den Bruel A, Lasserson D, Hayward G, Vach W, de Jong A, Burggraaff C, Hoekstra O, Zijlstra J, de Vet H, Hunt H, Hyde C, Graziadio S, Allen J, Johnston L, O'Leary R, Power M, Allen J, Graziadio S, Johnson L, O'Leary R, Power M, Waters R, Simpson J, Johnston L, Allen J, Graziadio S, O'Leary R, Waters R, Power M, Mallett S, Fanshawe TR, Phillips P, Plumb A, Helbren E, Halligan S, Taylor SA, Gale A, Mallett S, Sekula P, Altman DG, Sauerbrei W, Mallett S, Fanshawe TR, Forman JR, Dutton SJ, Takwoingi Y, Hensor EM, Nichols TE, Shinkins B, Yang Y, Abel L, Di Ruffano LF, Fanshawe T, Kempf E, Porcher R, de Beyer J, Moons K, Altman D, Reitsma H, Hopewell S, Sauerbrei W, Collins G, Dennis J, Shields B, Jones A, Henley W, Pearson E, Hattersley A, Heus P, Damen JAAG, Pajouheshnia R, Scholten RJPM, Reitsma JB, Collins GS, Altman DG, Moons KGM, Hooft L, Shields B, Dennis J, Jones A, Henley W, Pearson E, Hattersley A, Scheibler F, Rummer A, Sturtz S, Großelfinger R, Banister K, Ramsay C, Azuara-Blanco A, Cook J, Boachie C, Burr J, Kumarasamy M, Bourne R, Uchegbu I, Borsci S, Murphy J, Hanna G, Uchegbu I, Carter A, Murphy J, Ni M, Marti J, Eatock J, Uchegbu I, Robotham J, Dudareva M, Gilchrist M, Holmes A, Uchegbu I, Borsci S, Monaghan P, Lord S, StJohn A, Sandberg S, Cobbaert C, Lennartz L, Verhagen-Kamerbeek W, Ebert C, Bossuyt P, Horvath A, Jenniskens K, Naaktgeboren C, Reitsma J, Moons K, de Groot J, Hyde C, Peters J, Grigore B, Peters J, Hyde C, Hyde C, Ukoumunne O, Peters J, Zhelev Z, Levis B, Benedetti A, Levis AW, Ioannidis JPA, Shrier I, Cuijpers P, Gilbody S, Kloda LA, McMillan D, Patten SB, Steele RJ, Ziegelstein RC, Bombardier CH, Osório FL, Fann JR, Gjerdingen D, Lamers F, Lotrakul M, Loureiro SR, Löwe B, Shaaban J, Stafford L, van Weert HCPM, Whooley MA, Williams LS, Wittkampf KA, Yeung AS, Thombs BD, Peters J, Cooper C, Buchanan J, Nieto T, Smith C, Tucker O, Dretzke J, Beggs A, Rai N, Davenport C, Bayliss S, Stevens S, Snell K, Mallet S, Deeks J, Sundar S, Hall E, Porta N, Estelles DL, and de Bono J
- Abstract
[This corrects the article DOI: 10.1186/s41512-016-0001-y.].
- Published
- 2017
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