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5. Investigating a Novel Activation-Repolarisation Time Metric to Predict Localised Vulnerability to Reentry Using Computational Modelling

Author

Hill, Yolanda R., primary, Child, Nick, additional, Hanson, Ben, additional, Wallman, Mikael, additional, Coronel, Ruben, additional, Plank, Gernot, additional, Rinaldi, Christopher A., additional, Gill, Jaswinder, additional, Smith, Nicolas P., additional, Taggart, Peter, additional, and Bishop, Martin J., additional

Published
2016
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7. T1 Mapping in Discrimination of Hypertrophic Phenotypes: Hypertensive Heart Disease and Hypertrophic Cardiomyopathy

Author

Hinojar, Rocio, primary, Varma, Niharika, additional, Child, Nick, additional, Goodman, Benjamin, additional, Jabbour, Andrew, additional, Yu, Chung-Yao, additional, Gebker, Rolf, additional, Doltra, Adelina, additional, Kelle, Sebastian, additional, Khan, Sitara, additional, Rogers, Toby, additional, Arroyo Ucar, Eduardo, additional, Cummins, Ciara, additional, Carr-White, Gerald, additional, Nagel, Eike, additional, and Puntmann, Valentina O., additional

Published
2015
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8. Abstract 15154: T1-mapping and Outcomes in Non-ischemic Cardiomyopathies- An Investigator-led Multicenter Observational Longitudinal Study

Author

Puntmann, Valentina O, primary, Carr-White, Gerry, additional, Jabbour, Andrew, additional, Yu, Chung-Yao, additional, Gebker, Rolf, additional, Kelle, Sebastian, additional, Hinojar, Rocio, additional, Doltra, Ada, additional, Varma, Niharika, additional, Child, Nick, additional, Rogers, Toby, additional, Arroyo Ucar, Eduardo, additional, Goodman, Ben, additional, Suna, Gonca, additional, Khan, Sitara, additional, Dabir, Darius, additional, Herrmann, Eva, additional, Zeiher, Andreas M, additional, and Nagel, Eike, additional

Published
2015
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10. Left Ventricular Epicardial Electrograms Show Divergent Changes in Action Potential Duration in Responders and Nonresponders to Cardiac Resynchronization Therapy

Author

Chen, Zhong, primary, Hanson, Ben, additional, Sohal, Manav, additional, Sammut, Eva, additional, Child, Nick, additional, Shetty, Anoop, additional, Boucher, Ryan, additional, Bostock, Julian, additional, Gill, Jaswinder, additional, Carr-White, Gerald, additional, Rinaldi, C. Aldo, additional, and Taggart, Peter, additional

Published
2013
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11. Effect of autonomic blocking agents on the respiratory-related oscillations of ventricular action potential duration in humans.

Author

van Duijvenboden S, Hanson B, Child N, Orini M, Rinaldi CA, Gill JS, and Taggart P

Subjects
Adrenergic beta-Antagonists pharmacology, Aged, Anti-Arrhythmia Agents pharmacology, Atropine pharmacology, Blood Pressure drug effects, Electrocardiography drug effects, Female, Heart Rate drug effects, Heart Ventricles physiopathology, Humans, Male, Metoprolol pharmacology, Middle Aged, Muscarinic Antagonists pharmacology, Parasympatholytics pharmacology, Tachycardia, Supraventricular physiopathology, Ventricular Function, Left drug effects, Ventricular Function, Right drug effects, Action Potentials drug effects, Autonomic Nerve Block, Heart Ventricles drug effects, Respiratory Mechanics
Abstract

Ventricular action potential duration (APD) is an important component of many physiological functions including arrhythmogenesis. APD oscillations have recently been reported in humans at the respiratory frequency. This study investigates the contribution of the autonomic nervous system to these oscillations. In 10 patients undergoing treatment for supraventricular arrhythmias, activation recovery intervals (ARI; a conventional surrogate for APD) were measured from multiple left and right ventricular (RV) endocardial sites, together with femoral artery pressure. Respiration was voluntarily regulated and heart rate clamped by RV pacing. Sympathetic and parasympathetic blockade was achieved using intravenous metoprolol and atropine, respectively. Metroprolol reduced the rate of pressure development (maximal change in pressure over time): 1,271 (± 646) vs. 930 (± 433) mmHg/s; P < 0.01. Systolic blood pressure (SBP) showed a trend to decrease after metoprolol, 133 (± 21) vs. 128 (± 25) mmHg; P = 0.06, and atropine infusion, 122 (± 26) mmHg; P < 0.05. ARI and SBP exhibited significant cyclical variations (P < 0.05) with respiration in all subjects with peak-to-peak amplitudes ranging between 0.7 and 17.0 mmHg and 1 and 16 ms, respectively. Infusion of metoprolol reduced the mean peak-to-peak amplitude [ARI, 6.2 (± 1.4) vs. 4.4 (± 1.0) ms, P = 0.008; SBP, 8.4 (± 1.6) vs. 6.2 (± 2.0) mmHg, P = 0.002]. The addition of atropine had no significant effect. ARI, SBP, and respiration showed significant coupling (P < 0.05) at the breathing frequency in all subjects. Directed coherence from respiration to ARI was high and reduced after metoprolol infusion [0.70 (± 0.17) vs. 0.50 (± 0.23); P < 0.05]. These results suggest a role of respiration in modulating the electrophysiology of ventricular myocardium in humans, which is partly, but not totally, mediated by β-adrenergic mechanisms., (Copyright © 2015 the American Physiological Society.)

Published
2015
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