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The cutting thickness of the flame cutting nozzle mainly depends on the characteristics of the cutting oxygen jet, and in the process of designing and manufacturing a flame cutting nozzle with an ultralarge thickness, it is impossible to carry out multiple experiments to optimize the design due to the difficulty in testing, safety, manufacturing cost, environmental pollution, and other problems. In this paper, the Laval-type cutting oxygen orifice channel was first designed by theoretical calculation, the pressure, velocity, Mach number, and density distribution characteristics of the cutting oxygen jet were investigated by numerical simulation, and the reliability and adaptability of the numerical simulation results were verified by experiments. Then, the numerical simulation comparison and estimation method of jet characteristics with the general-purpose G301-7# nozzle was used to study the cutting oxygen orifice channel of the ultralarge thickness flame cutting nozzle. The results show that under the condition of a 19 mm throat diameter and 10 atm inlet pressure, it was estimated that the length of cutting oxygen flow from the design nozzle can reach 1800 mm and the cutting thickness can reach 2500 mm based on the density value; the length of cutting oxygen flow can reach 2000 mm and the cutting thickness can reach 3800 mm based on the velocity value; the length of cutting oxygen flow can reach 1600 mm according to the value of the oxygen quality fraction; and the cutting thickness can reach 2800 mm based on the oxygen mass fraction content. Finally, trial production of the nozzle design, verification of the cutting test, the nozzle with a cutting thickness of 2500 mm at an oxygen pressure of 7 atm, and the cutting quality were all good.

Abstract Gastric cancer is one of the most common malignant tumors, and chemotherapy is the main treatment for advanced gastric cancer. However, chemotherapy resistance leads to treatment failure and poor prognosis in patients with gastric cancer. Multidrug resistance (MDR) is a major challenge that needs to be overcome in chemotherapy. According to recent research, ferroptosis activation is crucial for tumor therapeutic strategies. In this work, we explored the solution to chemoresistance in gastric cancer by investigating the effects of the Chinese medicine monomer baicalin on ferroptosis. Baicalin with different concentrations was used to treat the parent HGC27 and drug-resistant HGC27/L cells of gastric cancer. Cell viability was measured by CCK8, and synergistic effects of baicalin combined with oxaliplatin were evaluated using Synergy Finder software. The effects of baicalin on organelles and cell morphology were investigated using projective electron microscopy. Iron concentration, MDA production and GSH inhibition rate were measured by colorimetry. ROS accumulation was detected by flow cytometry. The ferroptosis-related genes (IREB2, TfR, GPX4, FTH1), P53, and SLC7A11 were analysed by Western blot, and the expression differences of the above proteins between pretreatment and pretreatment of different concentrations of baicalin, were assayed in both parental HGC27 cells and Oxaliplatin-resistant HGC27/L cells. Mechanically, Baicalin disrupted iron homeostasis and inhibits antioxidant defense, resulting in iron accumulation, lipid peroxide aggregation, and specifically targeted and activated ferroptosis by upregulating the expression of tumor suppressor gene p53, thereby activating the SLC7A11/GPX4/ROS pathway mediated by it. Baicalin activates ferroptosis through multiple pathways and targets, thereby inhibiting the viability of oxaliplatin-resistant gastric cancer HGC27/L cells and enhancing the sensitivity to oxaliplatin chemotherapy.

Abstract This paper presents a general theoretical framework for understanding the Belt‐and‐Road Initiative (BRI). We begin with an introduction to the connotations of the BRI and a review of the initiative's main achievements since its inception. From these achievements, we identify the existence of a potential match between supply and demand in jointly building the BRI to be the foremost necessary condition for win–win cooperation for participating countries. Several features of China's contemporary economic structure are shown to provide the huge potential of supply that matches the massive demand of many Belt‐and‐Road countries for infrastructure development. To unleash the full potential of the BRI, a series of sufficient conditions must be met so that supply and demand interact in a virtuous manner. In the first stage of jointly building the BRI, the key to turn the initiative's potential into reality is to develop the “Five Links” of policy coordination, infrastructure connectivity, unimpeded trade, financial integration, and people‐to‐people bond. Now that the BRI has entered the high‐quality development stage, we demonstrate that China has taken or needs to work on policy measures in 10 areas to ensure the continuing and sustainable success of the BRI construction.

Abstract To rapidly obtain the complete characterization information of pulse signals and to verify the sensitivity and validity of pulse signals in the clinical diagnosis of related diseases. In this paper, an improved PNCC method is proposed as a supplementary feature to enable the complete characterization of pulse signals. In this paper, the wavelet scattering method is used to extract time-domain features from impulse signals, and EEMD-based improved PNCC (EPNCC) is used to extract frequency-domain features. The time–frequency features are mixed into a convolutional neural network for final classification and recognition. The data for this study were obtained from the MIT-BIH-mimic database, which was used to verify the effectiveness of the proposed method. The experimental analysis of three types of clinical symptom pulse signals showed an accuracy of 98.3% for pulse classification and recognition. The method is effective in complete pulse characterization and improves pulse classification accuracy under the processing of the three clinical pulse signals used in the paper.

Abstract Negative effects of long‐term overgrazing have been seriously, grasslands temporal stability is an important ecological concern we need to research. Here, we performed a 12‐year‐long (2007–2018) two‐factor controlled experiment on Kobresia humilis meadow on the Tibetan Plateau. The manipulations included three clipping levels (no clipping, NC; moderate clipping, MC; heavy clipping, HC) and two fertilization levels (no fertilization, NF; fertilization, F). Our results revealed that the two clipping manipulations significantly increased the temporal stability of alpine meadow communities, whose significant increase was more pronounced under the MC than HC treatment. Species asynchrony had a significant positive correlation with species abundance along with compound community gradient. Moreover, asynchrony effects, portfolio effects, and facilitation interactions were all present in the communities under the six types of experimental treatment combinations. Additionally, a selection effect was detected in the compound communities, demonstrating characteristics that are common to different mechanisms. There were no significant differences in the effects of these mechanisms on community temporal stability between the NC–NF and MC–NF interactive communities. The portfolio effects predominated when clipping intensity was moderate under both fertilization and nonfertilization conditions. By contrast, in the compound communities, the selection effect predominated. In summary, we conclude that in meadow communities that undergo clipping and fertilization disturbances, facilitation interactions and weak interactions make a greater contribution toward maintaining their temporal stability.

Wave energy provides a renewable and clear power for the future energy mix and fights against climate change. Currently, there are many different wave energy converters, but their costs of extracting wave energy are still much higher than other matured renewables. One of the best indicators of calculating the generating cost of wave energy is the ‘levelized cost of energy’ (LCOE), which is the combined capital expenditure (CAPEX), operational expenditure (OPEX), and decommissioning cost with the inclusion of the annual energy production, discount factor, and project’s lifespan. However, the results of the LCOE are in disagreement. Hence, it is important to explore the cost breakdown of wave energy by the wave energy converter (WEC), so for finding potential ways to decrease the cost, and finally compare it with other renewable energies. Different WECs have been installed in the same place; the Wave Dragon LCOE platform is the best one, with an energy conversion of EUR 316.90/MWh, followed by Pelamis with EUR 735.94/MWh and AquaBuOY with EUR 2967.85/MWh. Even when using different locations to test, the rank of the LCOE would remain unchanged with the different value. As the CAPEX and OPEX dramatically drop, the availability and capacity factors slowly increase, and the LCOE decreases from a maximum of USD 470/MWh to a minimum of USD 120/MWh. When the discount rate is down from 11% to 6%, the LCOE reduces from USD 160/MWh to USD 102/MWh. Under the ideal condition of the optimal combination of multiple factors, in theory, the LCOE can be less than USD 0.3/KWh. To better explore the LCOE for WECs, the detailed cost elements found in the CAPEX and OPEX have been examined for the scenarios of the undiscounted, half-discounted, and discounted cost models. When the AEP is discounted, the lowest LCOE is equal to USD 1.171/kWh in scene 2 when using a five-step investment, which is below the LCOE value of USD 1.211/kWh in scene 1 when using a two-step investment. Meanwhile, the highest LCOE amounts to USD 2.416/kWh using the five-step investment, whose value is below the LCOE of a two-step investment. When using a one-step investment in scene 3, the lowest LCOE is equal to USD 0.296/kWh, which accounts for 25% of the lowest value in the five-step investment. Meanwhile, the highest LCOE amounts to USD 0.616/kWh, which accounts for 24% of the highest value in the two-step investment. The results of the case study show that a one-step investment program in the half-discounted model is superior to the multi-step investment in the discounted model. This paper examines the viability of wave energy technologies, which is a critical factor for the LCOE of wave energy; furthermore, the form of investment in the wave energy project is also important when calculating the LCOE.

The start-up of a high temperature heat pipe is a complex multi-phase transition and flow heat transfer process, which may result in heat transfer oscillations, causing fluctuations in the heat pipe temperature and thus affecting the operational safety of the reactor. In this study, for the high temperature sodium heat pipe with a length of 1 000 mm and a diameter of 20 mm, the evolution law of the heat transfer oscillation was summarized through start-up experiments under vertical and horizontal conditions. The finite element thermal-mechanical simulation and thermal fatigue program analysis of a localized heat pipe reactor core design with generalized characteristics were carried out, and the stress response and the consequences of fatigue damage induced by heat pipe heat transfer oscillations were investigated. The experimental results show that the change of sodium evaporation rate causes the change of heat pipe pressure under vertical condition, which affects the evaporation and reflux balance of working medium, and causes the oscillation of heat transfer in different characteristics during start-up process. Enhancing the input power will shorten the frequency and decrease the amplitude of the oscillation. When the heat flow density increases from 9 973.71 W/m2 to 12 452.28 W/m2, the temperature oscillation amplitude decreases by nearly 30% and the oscillation period is shortened by about 40%. In the heat transfer oscillation state, the heat pipe will still maintain the heat transfer oscillation when the input power is suddenly reduced, but the waveform changes from a sawtooth shape to a trapezoid shape. The oscillation is obviously suppressed under horizontal condition. Simulation results show that, when the high temperature heat pipe heat transfer oscillation occurs, the thermal fatigue failure risk area of the localized reactor core is the inner wall of the evaporation section of the heat pipe. Fatigue damage is the largest in same-phase oscillation. The average value of the stress increases when the peak temperature difference increases due to the phase difference of oscillation, but because the decrease in the amplitude of stress of different-phase condition, the fatigue damage is reduced compared to the same-phase condition. Considering the effect of the conservatism deviation and creep on the fatigue damage, the thermal fatigue analysis is based on the safety factor K. Fatigue safety analysis results show that when the safety factor K is lower than 1.4 there is almost no risk of fatigue failure. K reaches 1.4 or more fatigue damage is gradually significant. When K=1.6 the fatigue life of the pipe wall material reduces to 3.29 years. This study is of great significance in analyzing the mechanism of heat transfer oscillation of high temperature sodium heat pipe and improving the reliability assessment of heat pipe.

Aggregate signcryption can combine ciphertext generated by different signcryption on different messages into a single ciphertext, which greatly reduces the total length of ciphertext and verification cost, and is more sui-table for low bandwidth and low storage communication environment. To solve the problems of poor security and inefficiency of aggregate signcryption with bilinear pairings in identity based cryptosystem, a new certificateless aggregate signcryption scheme which is based on a secure and efficient signature scheme and can be publicly verified without pair operation is designed. Hash function is used to bind the signcrypter’s identity information with part of the public key to generate part of the user’s private key to prevent public key replacement attacks. In the de-signcryption stage, the signcrypter’s identity information is taken as the output, which can verify the legitimacy of signcrypter’s identity and effectively hide it. In the random oracle model, the confidentiality and unforgeability of the scheme are reduced to the solving of computational Diffie-Hellman problem and discrete logarithm problem in polynomial time, which proves the security of the scheme. In the verification phase, any trusted third party can verify without any user’s private information, which proves the scheme has public verification. Furthermore, the efficiency of the scheme is compared. The proposed scheme only needs 3 n point multiplication operations in the aggregation de-signcryption stage, so it is more efficient.

Safe and reliable energy supply is the key foundation for the development of unmanned underwater vehicle (UUV). Unlike land and space missions, underwater missions are more demanding on energy, which requires higher power level, longer operating time, faster response time, and better concealment. Heat pipe cooled reactor has the advantages of large power capacity, simple structure, easy control of reactivity, and rapid thermal response. The solid-state reactor core does not require coolant and relies entirely on heat pipes to dissipate heat, thereby providing good inherent safety, controllability and concealment. Therefore, heat pipe cooled reactor is considered as one of the most promising options for UUV energy supply. In this study, a conceptual design of Nuclear Silent Thermal-Electrical Reactor (NUSTER-100) was proposed to meet the energy requirement of China’s heavy ocean UUV research and development. 109 sodium heat pipes were arranged in the reactor core for passive cooling, and the thermoelectric generators (TEGs) were employed in the reactor to convert fission heat to electric power. A set of heat pipe cooled reactor system-wild mathematical and physical models were established, including core neutron physics model, core channel heat transfer model, heat pipe model, thermoelectric conversion model and cold junction heat transfer mode. Based on the efficient and robust numerical algorithm and modular modeling ideas, heat pipe advanced reactor transient analysis code HEART was developed with independent intellectual property rights, and the key modules of HEART were validated and verified by heat pipe experiment and thermoelectric power experiment. The steady-state, cold-start transient and reactivity insertion transient conditions of NUSTER-100 were calculated and analyzed by HEART, and the full power operation characteristics of NUSTER-100 were obtained. Steady-state performance of the NUSTER-100 indicates that the solid-state core has good temperature flattening ability. The surface temperature of the heat pipe is less than 1 300 K, and the average temperature drop of the TEG module in central channel is 724 K, which can produce an electrical power of 1 207.8 W. Based on the cold-start transient thermal-hydraulic analysis, a three-stage heat pipe cooled reactor start-up scheme with high safety was proposed, and the stability and safety of heat pipe reactor under reactivity insertion transient were evaluated. The results show that the three-stage heat pipe cooled reactor start-up scheme can improve the reactor start-up efficiency. This study can provide support for the development of UUV and heat pipe cooled reactor technology in China.