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Cellular communication plays a critical role in diverse aspects of tumorigenesis including tumor cell growth/death, adhesion/detachment, migration/invasion, angiogenesis, and metastasis. G protein-coupled receptors (GPCRs) which constitute the largest group of cell surface receptors are known to play fundamental roles in all these processes. When considering the importance of GPCRs in tumorigenesis, the adhesion GPCRs (aGPCRs) are unique due to their hybrid structural organization of a long extracellular cell-adhesive domain and a seven-transmembrane signaling domain. Indeed, aGPCRs have been increasingly shown to be associated with tumor development by participating in tumor cell interaction and signaling. ADGRG1/GPR56, a representative tumor-associated aGPCR, is recognized as a potential biomarker/prognostic factor of specific cancer types with both tumor-suppressive and tumor-promoting functions. We summarize herein the latest findings of the role of ADGRG1/GPR56 in tumor progression.

Typhoon passages across Taiwan can generate sudden surface warming in downslope regions. Special characteristics and mechanisms for 54 such warming events that were identified during the 1961–2007 period are examined. Preferred warming regions were identified in northwest Taiwan, where warming is generated by downslope flow from east or northeast winds in westward-moving typhoons, and in southeast Taiwan, where it is generated by downslope flow from west or northwest winds in northwestward-moving typhoons. In addition to the orographic effect, warmings occurred exclusively within nonprecipitation zones of typhoons. Most northwest (southeast) warmings occur during the day (night) with an average lifetime of 4 (5) h, which roughly corresponds to the average time a nonprecipitation zone remains over a station. During the period examined, three typhoons generated warming events in both northwest and southeast Taiwan, and only Typhoon Haitang (2005) generated warmings with comparable magnitudes ( ; 12-K increase) in both regions. For Typhoon Haitang as an example, diagnostic analyses with two different approaches reveal that the majority of the warming is contributed by downslope adiabatic warming, but the warming associated with the passage of a nonprecipitation zone is not negligible. Similar results were found when these two diagnostic approaches were applied to the other warming events. The diurnal mode of the atmospheric divergent circulation over East Asia–western North Pacific undergoes a clockwise rotation. The vorticity tendency generated by this diurnal divergent circulation through vortex stretching may modulate the arrival time of typhoons to cause daily (nighttime) warming in the northwest (southeast).

In the U.S. northern plains, summer progressive convective storms that occur in weakly forced environ- ments are often coupled with short-wave perturbations that are embedded in the midlevel northwesterly flow. These midtropospheric perturbations (MPs) are capable of inducing propagating convection that contributes to a majority of the rainfall over the northern plains during July and August. There is a possibility that the difficulties of numerical weather prediction models in forecasting summer convective rainfall over the northern plains are partly attributed to their deficiency in forecasting MPs. The present study tests this possibility through examining operational forecasts by the North American Mesoscale (NAM) model during the summers of 2005 and 2006. Forecasted MPs exhibit slower propagation speeds and weaker relative vorticity than the observations leading to systematic position errors. Underpredicted vorticity magnitudes weaken horizontal vorticity ad- vection that influences the vorticity tendency throughout the MP life cycle and, in turn, slows the propagation speed of MPs. Moreover, biases of weak ambient flow speed and vortex stretching contribute to the mag- nitude and propagation speed errors of MPs. Skill scores of precipitation forecasts associated with MPs are low, but can be considerably improved after removing the MP position error that displaces the rainfall pat- tern. The NAM also tends to underpredict precipitation amounts. A modified water vapor budget analysis reveals that the NAM insufficiently generates atmospheric humidity over the central United States. The shortage of moisture in the forecast reduces the water vapor flux convergence that is part of the precipitation process. The precipitation bias may feed back to affect the MP growththrough the bias in heating, thus further slowing the perturbation.