48 results on '"Chen, Shuxiao"'
Search Results
2. The Role of Placebo Samples in Observational Studies
- Author
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Ye, Ting, Chen, Shuxiao, and Zhang, Bo
- Subjects
Statistics - Methodology ,Statistics - Applications - Abstract
In an observational study, it is common to leverage known null effect to detect bias. One such strategy is to set aside a placebo sample -- a subset of data immune from the hypothesized cause-and-effect relationship. Existence of an effect in the placebo sample raises concern of unmeasured confounding bias while absence of it corroborates the causal conclusion. This paper establishes a formal framework for using a placebo sample to detect and remove bias. We state identification assumption, and develop estimation and inference methods based on outcome regression, inverse probability weighting, and doubly-robust approaches. Simulation studies and an empirical application illustrate the finite-sample performance of the proposed methods.
- Published
- 2022
3. One-Way Matching of Datasets with Low Rank Signals
- Author
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Chen, Shuxiao, Jiang, Sizun, Ma, Zongming, Nolan, Garry P., and Zhu, Bokai
- Subjects
Mathematics - Statistics Theory ,Computer Science - Information Theory ,Computer Science - Machine Learning ,Quantitative Biology - Quantitative Methods - Abstract
We study one-way matching of a pair of datasets with low rank signals. Under a stylized model, we first derive information-theoretic limits of matching under a mismatch proportion loss. We then show that linear assignment with projected data achieves fast rates of convergence and sometimes even minimax rate optimality for this task. The theoretical error bounds are corroborated by simulated examples. Furthermore, we illustrate practical use of the matching procedure on two single-cell data examples.
- Published
- 2022
4. Perception-aware receding horizon trajectory planning for multicopters with visual-inertial odometry
- Author
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Wu, Xiangyu, Chen, Shuxiao, Sreenath, Koushil, and Mueller, Mark W.
- Subjects
Computer Science - Robotics - Abstract
Visual inertial odometry (VIO) is widely used for the state estimation of multicopters, but it may function poorly in environments with few visual features or in overly aggressive flights. In this work, we propose a perception-aware collision avoidance trajectory planner for multicopters, that may be used with any feature-based VIO algorithm. Our approach is able to fly the vehicle to a goal position at fast speed, avoiding obstacles in an unknown stationary environment while achieving good VIO state estimation accuracy. The proposed planner samples a group of minimum jerk trajectories and finds collision-free trajectories among them, which are then evaluated based on their speed to the goal and perception quality. Both the motion blur of features and their locations are considered for the perception quality. Our novel consideration of the motion blur of features enables automatic adaptation of the trajectory's aggressiveness under environments with different light levels. The best trajectory from the evaluation is tracked by the vehicle and is updated in a receding horizon manner when new images are received from the camera. Only generic assumptions about the VIO are made, so that the planner may be used with various existing systems. The proposed method can run in real-time on a small embedded computer on board. We validated the effectiveness of our proposed approach through experiments in both indoor and outdoor environments. Compared to a perception-agnostic planner, the proposed planner kept more features in the camera's view and made the flight less aggressive, making the VIO more accurate. It also reduced VIO failures, which occurred for the perception-agnostic planner but not for the proposed planner. The ability of the proposed planner to fly through dense obstacles was also validated. The experiment video can be found at https://youtu.be/qO3LZIrpwtQ., Comment: 12 pages
- Published
- 2022
5. Learning Torque Control for Quadrupedal Locomotion
- Author
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Chen, Shuxiao, Zhang, Bike, Mueller, Mark W., Rai, Akshara, and Sreenath, Koushil
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Computer Science - Robotics ,Computer Science - Artificial Intelligence ,Electrical Engineering and Systems Science - Systems and Control - Abstract
Reinforcement learning (RL) has become a promising approach to developing controllers for quadrupedal robots. Conventionally, an RL design for locomotion follows a position-based paradigm, wherein an RL policy outputs target joint positions at a low frequency that are then tracked by a high-frequency proportional-derivative (PD) controller to produce joint torques. In contrast, for the model-based control of quadrupedal locomotion, there has been a paradigm shift from position-based control to torque-based control. In light of the recent advances in model-based control, we explore an alternative to the position-based RL paradigm, by introducing a torque-based RL framework, where an RL policy directly predicts joint torques at a high frequency, thus circumventing the use of a PD controller. The proposed learning torque control framework is validated with extensive experiments, in which a quadruped is capable of traversing various terrain and resisting external disturbances while following user-specified commands. Furthermore, compared to learning position control, learning torque control demonstrates the potential to achieve a higher reward and is more robust to significant external disturbances. To our knowledge, this is the first sim-to-real attempt for end-to-end learning torque control of quadrupedal locomotion.
- Published
- 2022
6. Vision-aided Dynamic Quadrupedal Locomotion on Discrete Terrain using Motion Libraries
- Author
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Agrawal, Ayush, Chen, Shuxiao, Rai, Akshara, and Sreenath, Koushil
- Subjects
Computer Science - Robotics ,Electrical Engineering and Systems Science - Systems and Control ,Mathematics - Optimization and Control - Abstract
In this paper, we present a framework rooted in control and planning that enables quadrupedal robots to traverse challenging terrains with discrete footholds using visual feedback. Navigating discrete terrain is challenging for quadrupeds because the motion of the robot can be aperiodic, highly dynamic, and blind for the hind legs of the robot. Additionally, the robot needs to reason over both the feasible footholds as well as robot velocity by speeding up and slowing down at different parts of the terrain. We build an offline library of periodic gaits which span two trotting steps on the robot, and switch between different motion primitives to achieve aperiodic motions of different step lengths on an A1 robot. The motion library is used to provide targets to a geometric model predictive controller which controls stance. To incorporate visual feedback, we use terrain mapping tools to build a local height map of the terrain around the robot using RGB and depth cameras, and extract feasible foothold locations around both the front and hind legs of the robot. Our experiments show a Unitree A1 robot navigating multiple unknown, challenging and discrete terrains in the real world., Comment: Accepted to ICRA 2022
- Published
- 2021
7. Minimax Rates and Adaptivity in Combining Experimental and Observational Data
- Author
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Chen, Shuxiao, Zhang, Bo, and Ye, Ting
- Subjects
Statistics - Methodology ,Mathematics - Statistics Theory - Abstract
Randomized controlled trials (RCTs) are the gold standard for evaluating the causal effect of a treatment; however, they often have limited sample sizes and sometimes poor generalizability. On the other hand, non-randomized, observational data derived from large administrative databases have massive sample sizes and better generalizability, but they are prone to unmeasured confounding bias. It is thus of considerable interest to reconcile effect estimates obtained from randomized controlled trials and observational studies investigating the same intervention, potentially harvesting the best from both realms. In this paper, we theoretically characterize the potential efficiency gain of integrating observational data into the RCT-based analysis from a minimax point of view. For estimation, we derive the minimax rate of convergence for the mean squared error, and propose a fully adaptive anchored thresholding estimator that attains the optimal rate up to poly-log factors. For inference, we characterize the minimax rate for the length of confidence intervals and show that adaptation (to unknown confounding bias) is in general impossible. A curious phenomenon thus emerges: for estimation, the efficiency gain from data integration can be achieved without prior knowledge on the magnitude of the confounding bias; for inference, the same task becomes information-theoretically impossible in general. We corroborate our theoretical findings using simulations and a real data example from the RCT DUPLICATE initiative [Franklin et al., 2021b].
- Published
- 2021
8. Autonomous Navigation of Underactuated Bipedal Robots in Height-Constrained Environments
- Author
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Li, Zhongyu, Zeng, Jun, Chen, Shuxiao, and Sreenath, Koushil
- Subjects
Computer Science - Robotics ,Computer Science - Artificial Intelligence ,Electrical Engineering and Systems Science - Systems and Control - Abstract
Navigating a large-scaled robot in unknown and cluttered height-constrained environments is challenging. Not only is a fast and reliable planning algorithm required to go around obstacles, the robot should also be able to change its intrinsic dimension by crouching in order to travel underneath height-constrained regions. There are few mobile robots that are capable of handling such a challenge, and bipedal robots provide a solution. However, as bipedal robots have nonlinear and hybrid dynamics, trajectory planning while ensuring dynamic feasibility and safety on these robots is challenging. This paper presents an end-to-end autonomous navigation framework which leverages three layers of planners and a variable walking height controller to enable bipedal robots to safely explore height-constrained environments. A vertically-actuated Spring-Loaded Inverted Pendulum (vSLIP) model is introduced to capture the robot's coupled dynamics of planar walking and vertical walking height. This reduced-order model is utilized to optimize for long-term and short-term safe trajectory plans. A variable walking height controller is leveraged to enable the bipedal robot to maintain stable periodic walking gaits while following the planned trajectory. The entire framework is tested and experimentally validated using a bipedal robot Cassie. This demonstrates reliable autonomy to drive the robot to safely avoid obstacles while walking to the goal location in various kinds of height-constrained cluttered environments., Comment: Accepted in International Journal of Robotics Research (IJRR) 2023. This is the author's version and will no longer be updated as the copyright may get transferred at anytime
- Published
- 2021
9. Real-time Geo-localization Using Satellite Imagery and Topography for Unmanned Aerial Vehicles
- Author
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Chen, Shuxiao, Wu, Xiangyu, Mueller, Mark W., and Sreenath, Koushil
- Subjects
Computer Science - Robotics ,Computer Science - Computer Vision and Pattern Recognition - Abstract
The capabilities of autonomous flight with unmanned aerial vehicles (UAVs) have significantly increased in recent times. However, basic problems such as fast and robust geo-localization in GPS-denied environments still remain unsolved. Existing research has primarily concentrated on improving the accuracy of localization at the cost of long and varying computation time in various situations, which often necessitates the use of powerful ground station machines. In order to make image-based geo-localization online and pragmatic for lightweight embedded systems on UAVs, we propose a framework that is reliable in changing scenes, flexible about computing resource allocation and adaptable to common camera placements. The framework is comprised of two stages: offline database preparation and online inference. At the first stage, color images and depth maps are rendered as seen from potential vehicle poses quantized over the satellite and topography maps of anticipated flying areas. A database is then populated with the global and local descriptors of the rendered images. At the second stage, for each captured real-world query image, top global matches are retrieved from the database and the vehicle pose is further refined via local descriptor matching. We present field experiments of image-based localization on two different UAV platforms to validate our results., Comment: Accepted at 2021 IEEE/RSJ International Conference on Intelligent Robots and Systems (IROS)
- Published
- 2021
10. Organization of the human intestine at single-cell resolution
- Author
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Hickey, John W., Becker, Winston R., Nevins, Stephanie A., Horning, Aaron, Perez, Almudena Espin, Zhu, Chenchen, Zhu, Bokai, Wei, Bei, Chiu, Roxanne, Chen, Derek C., Cotter, Daniel L., Esplin, Edward D., Weimer, Annika K., Caraccio, Chiara, Venkataraaman, Vishal, Schürch, Christian M., Black, Sarah, Brbić, Maria, Cao, Kaidi, Chen, Shuxiao, Zhang, Weiruo, Monte, Emma, Zhang, Nancy R., Ma, Zongming, Leskovec, Jure, Zhang, Zhengyan, Lin, Shin, Longacre, Teri, Plevritis, Sylvia K., Lin, Yiing, Nolan, Garry P., Greenleaf, William J., and Snyder, Michael
- Published
- 2023
- Full Text
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11. Weighted Training for Cross-Task Learning
- Author
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Chen, Shuxiao, Crammer, Koby, He, Hangfeng, Roth, Dan, and Su, Weijie J.
- Subjects
Computer Science - Machine Learning ,Computer Science - Computation and Language ,Statistics - Machine Learning - Abstract
In this paper, we introduce Target-Aware Weighted Training (TAWT), a weighted training algorithm for cross-task learning based on minimizing a representation-based task distance between the source and target tasks. We show that TAWT is easy to implement, is computationally efficient, requires little hyperparameter tuning, and enjoys non-asymptotic learning-theoretic guarantees. The effectiveness of TAWT is corroborated through extensive experiments with BERT on four sequence tagging tasks in natural language processing (NLP), including part-of-speech (PoS) tagging, chunking, predicate detection, and named entity recognition (NER). As a byproduct, the proposed representation-based task distance allows one to reason in a theoretically principled way about several critical aspects of cross-task learning, such as the choice of the source data and the impact of fine-tuning., Comment: Published as a conference paper at ICLR 2022
- Published
- 2021
12. Estimating and Improving Dynamic Treatment Regimes With a Time-Varying Instrumental Variable
- Author
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Chen, Shuxiao and Zhang, Bo
- Subjects
Statistics - Methodology ,Computer Science - Machine Learning ,Economics - Econometrics ,Statistics - Machine Learning - Abstract
Estimating dynamic treatment regimes (DTRs) from retrospective observational data is challenging as some degree of unmeasured confounding is often expected. In this work, we develop a framework of estimating properly defined "optimal" DTRs with a time-varying instrumental variable (IV) when unmeasured covariates confound the treatment and outcome, rendering the potential outcome distributions only partially identified. We derive a novel Bellman equation under partial identification, use it to define a generic class of estimands (termed IV-optimal DTRs), and study the associated estimation problem. We then extend the IV-optimality framework to tackle the policy improvement problem, delivering IV-improved DTRs that are guaranteed to perform no worse and potentially better than a pre-specified baseline DTR. Importantly, our IV-improvement framework opens up the possibility of strictly improving upon DTRs that are optimal under the no unmeasured confounding assumption (NUCA). We demonstrate via extensive simulations the superior performance of IV-optimal and IV-improved DTRs over the DTRs that are optimal only under the NUCA. In a real data example, we embed retrospective observational registry data into a natural, two-stage experiment with noncompliance using a time-varying IV and estimate useful IV-optimal DTRs that assign mothers to high-level or low-level neonatal intensive care units based on their prognostic variables., Comment: 67 pages, 9 figures, 6 tables
- Published
- 2021
13. A Theorem of the Alternative for Personalized Federated Learning
- Author
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Chen, Shuxiao, Zheng, Qinqing, Long, Qi, and Su, Weijie J.
- Subjects
Statistics - Machine Learning ,Computer Science - Machine Learning - Abstract
A widely recognized difficulty in federated learning arises from the statistical heterogeneity among clients: local datasets often come from different but not entirely unrelated distributions, and personalization is, therefore, necessary to achieve optimal results from each individual's perspective. In this paper, we show how the excess risks of personalized federated learning with a smooth, strongly convex loss depend on data heterogeneity from a minimax point of view. Our analysis reveals a surprising theorem of the alternative for personalized federated learning: there exists a threshold such that (a) if a certain measure of data heterogeneity is below this threshold, the FedAvg algorithm [McMahan et al., 2017] is minimax optimal; (b) when the measure of heterogeneity is above this threshold, then doing pure local training (i.e., clients solve empirical risk minimization problems on their local datasets without any communication) is minimax optimal. As an implication, our results show that the presumably difficult (infinite-dimensional) problem of adapting to client-wise heterogeneity can be reduced to a simple binary decision problem of choosing between the two baseline algorithms. Our analysis relies on a new notion of algorithmic stability that takes into account the nature of federated learning., Comment: 50 pages (main manuscript: 25 pages, appendices: 25 pages)
- Published
- 2021
14. Federated $f$-Differential Privacy
- Author
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Zheng, Qinqing, Chen, Shuxiao, Long, Qi, and Su, Weijie J.
- Subjects
Statistics - Machine Learning ,Computer Science - Artificial Intelligence ,Computer Science - Cryptography and Security ,Computer Science - Computer Vision and Pattern Recognition ,Computer Science - Machine Learning - Abstract
Federated learning (FL) is a training paradigm where the clients collaboratively learn models by repeatedly sharing information without compromising much on the privacy of their local sensitive data. In this paper, we introduce federated $f$-differential privacy, a new notion specifically tailored to the federated setting, based on the framework of Gaussian differential privacy. Federated $f$-differential privacy operates on record level: it provides the privacy guarantee on each individual record of one client's data against adversaries. We then propose a generic private federated learning framework {PriFedSync} that accommodates a large family of state-of-the-art FL algorithms, which provably achieves federated $f$-differential privacy. Finally, we empirically demonstrate the trade-off between privacy guarantee and prediction performance for models trained by {PriFedSync} in computer vision tasks., Comment: Accepted to AISTATS 2021
- Published
- 2021
15. Global and Individualized Community Detection in Inhomogeneous Multilayer Networks
- Author
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Chen, Shuxiao, Liu, Sifan, and Ma, Zongming
- Subjects
Mathematics - Statistics Theory ,Computer Science - Information Theory ,Computer Science - Machine Learning - Abstract
In network applications, it has become increasingly common to obtain datasets in the form of multiple networks observed on the same set of subjects, where each network is obtained in a related but different experiment condition or application scenario. Such datasets can be modeled by multilayer networks where each layer is a separate network itself while different layers are associated and share some common information. The present paper studies community detection in a stylized yet informative inhomogeneous multilayer network model. In our model, layers are generated by different stochastic block models, the community structures of which are (random) perturbations of a common global structure while the connecting probabilities in different layers are not related. Focusing on the symmetric two block case, we establish minimax rates for both global estimation of the common structure and individualized estimation of layer-wise community structures. Both minimax rates have sharp exponents. In addition, we provide an efficient algorithm that is simultaneously asymptotic minimax optimal for both estimation tasks under mild conditions. The optimal rates depend on the parity of the number of most informative layers, a phenomenon that is caused by inhomogeneity across layers. The method is extended to handle multiple and potentially asymmetric community cases. We demonstrate its effectiveness on both simulated examples and a real multi-modal single-cell dataset., Comment: Accepted to Annals of Statistics
- Published
- 2020
16. Label-Aware Neural Tangent Kernel: Toward Better Generalization and Local Elasticity
- Author
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Chen, Shuxiao, He, Hangfeng, and Su, Weijie J.
- Subjects
Computer Science - Machine Learning ,Statistics - Machine Learning - Abstract
As a popular approach to modeling the dynamics of training overparametrized neural networks (NNs), the neural tangent kernels (NTK) are known to fall behind real-world NNs in generalization ability. This performance gap is in part due to the \textit{label agnostic} nature of the NTK, which renders the resulting kernel not as \textit{locally elastic} as NNs~\citep{he2019local}. In this paper, we introduce a novel approach from the perspective of \emph{label-awareness} to reduce this gap for the NTK. Specifically, we propose two label-aware kernels that are each a superimposition of a label-agnostic part and a hierarchy of label-aware parts with increasing complexity of label dependence, using the Hoeffding decomposition. Through both theoretical and empirical evidence, we show that the models trained with the proposed kernels better simulate NNs in terms of generalization ability and local elasticity., Comment: NeurIPS 2020 camera ready version, 32 pages, 2 figures, 3 tables
- Published
- 2020
17. A Group-Theoretic Framework for Data Augmentation
- Author
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Chen, Shuxiao, Dobriban, Edgar, and Lee, Jane H
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Statistics - Machine Learning ,Computer Science - Machine Learning ,Mathematics - Statistics Theory - Abstract
Data augmentation is a widely used trick when training deep neural networks: in addition to the original data, properly transformed data are also added to the training set. However, to the best of our knowledge, a clear mathematical framework to explain the performance benefits of data augmentation is not available. In this paper, we develop such a theoretical framework. We show data augmentation is equivalent to an averaging operation over the orbits of a certain group that keeps the data distribution approximately invariant. We prove that it leads to variance reduction. We study empirical risk minimization, and the examples of exponential families, linear regression, and certain two-layer neural networks. We also discuss how data augmentation could be used in problems with symmetry where other approaches are prevalent, such as in cryo-electron microscopy (cryo-EM)., Comment: To appear in Journal of Machine Learning Research
- Published
- 2019
18. Feedback Control for Autonomous Riding of Hovershoes by a Cassie Bipedal Robot
- Author
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Chen, Shuxiao, Rogers, Jonathan, Zhang, Bike, and Sreenath, Koushil
- Subjects
Computer Science - Robotics ,Electrical Engineering and Systems Science - Systems and Control - Abstract
Motivated towards achieving multi-modal locomotion, in this paper, we develop a framework for a bipedal robot to dynamically ride a pair of Hovershoes over various terrain. Our developed control strategy enables the Cassie bipedal robot to interact with the Hovershoes to balance, regulate forward and rotational velocities, achieve fast turns, and move over flat terrain, slopes, stairs, and rough outdoor terrain. Our sensor suite comprising of tracking and depth cameras for visual SLAM as well as our Dijkstra-based global planner and timed elastic band-based local planning framework enables us to achieve autonomous riding on the Hovershoes while navigating an obstacle course. We present numerical and experimental validations of our work.
- Published
- 2019
19. Valid Inference Corrected for Outlier Removal
- Author
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Chen, Shuxiao and Bien, Jacob
- Subjects
Statistics - Methodology ,Mathematics - Statistics Theory ,Statistics - Computation ,Statistics - Machine Learning - Abstract
Ordinary least square (OLS) estimation of a linear regression model is well-known to be highly sensitive to outliers. It is common practice to (1) identify and remove outliers by looking at the data and (2) to fit OLS and form confidence intervals and p-values on the remaining data as if this were the original data collected. This standard "detect-and-forget" approach has been shown to be problematic, and in this paper we highlight the fact that it can lead to invalid inference and show how recently developed tools in selective inference can be used to properly account for outlier detection and removal. Our inferential procedures apply to a general class of outlier removal procedures that includes several of the most commonly used approaches. We conduct simulations to corroborate the theoretical results, and we apply our method to three real data sets to illustrate how our inferential results can differ from the traditional detect-and-forget strategy. A companion R package, outference, implements these new procedures with an interface that matches the functions commonly used for inference with lm in R., Comment: 21 pages, 6 figures, 2 tables
- Published
- 2017
20. The impact of endovascular treatment on clinical outcomes of stable symptomatic patients with spontaneous superior mesenteric artery dissection
- Author
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Gao, Peixian, Li, Gang, Chen, Jianfeng, Qiu, Renfeng, Qiao, Changyu, Luo, Kun, Chen, Shuxiao, Wu, Xuejun, and Dong, Dianning
- Published
- 2021
- Full Text
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21. Efficient Construction of a C60 Interlayer for Mechanically Robust, Dendrite-free, and Ultrastable Solid-State Batteries
- Author
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Li, Zhenlong, Zhang, Siwei, Qian, Kun, Nie, Pengbo, Chen, Shuxiao, Zhang, Xuan, Li, Baohua, Li, Tao, Wei, Guodan, and Kang, Feiyu
- Published
- 2020
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22. Autonomous navigation of underactuated bipedal robots in height-constrained environments
- Author
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Li, Zhongyu, primary, Zeng, Jun, additional, Chen, Shuxiao, additional, and Sreenath, Koushil, additional
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- 2023
- Full Text
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23. Integration of spatial and single-cell data across modalities with weak linkage
- Author
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Chen, Shuxiao, Zhu, Bokai, Huang, Sijia, Hickey, John W., Lin, Kevin Z., Snyder, Michael, Greenleaf, William J., Nolan, Garry P., Zhang, Nancy R., and Ma, Zongming
- Subjects
Article - Abstract
single-cell sequencing methods have enabled the profiling of multiple types of molecular readouts at cellular resolution, and recent developments in spatial barcoding, in situ hybridization, and in situ sequencing allow such molecular readouts to retain their spatial context. Since no technology can provide complete characterization across all layers of biological modalities within the same cell, there is pervasive need for computational cross-modal integration (also called diagonal integration) of single-cell and spatial omics data. For current methods, the feasibility of cross-modal integration relies on the existence of highly correlated, a priori “linked” features. When such linked features are few or uninformative, a scenario that we call “weak linkage”, existing methods fail. We developed MaxFuse, a cross-modal data integration method that, through iterative co-embedding, data smoothing, and cell matching, leverages all information in each modality to obtain high-quality integration. MaxFuse is modality-agnostic and, through comprehensive benchmarks on single-cell and spatial ground-truth multiome datasets, demonstrates high robustness and accuracy in the weak linkage scenario. A prototypical example of weak linkage is the integration of spatial proteomic data with single-cell sequencing data. On two example analyses of this type, we demonstrate how MaxFuse enables the spatial consolidation of proteomic, transcriptomic and epigenomic information at single-cell resolution on the same tissue section.
- Published
- 2023
24. Vision-Aided Dynamic Quadrupedal Locomotion on Discrete Terrain Using Motion Libraries
- Author
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Agrawal, Ayush, Chen, Shuxiao, Rai, Akshara, and Sreenath, Koushil
- Subjects
FOS: Computer and information sciences ,Computer Science - Robotics ,Optimization and Control (math.OC) ,FOS: Electrical engineering, electronic engineering, information engineering ,FOS: Mathematics ,Systems and Control (eess.SY) ,Robotics (cs.RO) ,Electrical Engineering and Systems Science - Systems and Control ,Mathematics - Optimization and Control ,ComputingMethodologies_COMPUTERGRAPHICS - Abstract
In this paper, we present a framework rooted in control and planning that enables quadrupedal robots to traverse challenging terrains with discrete footholds using visual feedback. Navigating discrete terrain is challenging for quadrupeds because the motion of the robot can be aperiodic, highly dynamic, and blind for the hind legs of the robot. Additionally, the robot needs to reason over both the feasible footholds as well as robot velocity by speeding up and slowing down at different parts of the terrain. We build an offline library of periodic gaits which span two trotting steps on the robot, and switch between different motion primitives to achieve aperiodic motions of different step lengths on an A1 robot. The motion library is used to provide targets to a geometric model predictive controller which controls stance. To incorporate visual feedback, we use terrain mapping tools to build a local height map of the terrain around the robot using RGB and depth cameras, and extract feasible foothold locations around both the front and hind legs of the robot. Our experiments show a Unitree A1 robot navigating multiple unknown, challenging and discrete terrains in the real world., Accepted to ICRA 2022
- Published
- 2022
25. Learning from Multiple and Heterogeneous Datasets
- Author
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Chen, Shuxiao and Chen, Shuxiao
- Abstract
The advances in data-acquisition technologies have enabled statisticians to have access to multiple datasets with both globally overlapping and individually variable information. Focusing on applications in single-cell multi-omics, this dissertation concerns statistical methodologies and theories for the estimation of both the global and the individualized structures when multiple and heterogeneous datasets are available. This dissertation is composed of three parts. In the first part, we present MARIO, a robust pipeline for integrative analyses of multi-modal single-cell data that is particularly successful in low signal-to-noise (SNR) ratio scenarios. Currently available tools for single-cell data integration are mainly designed for transcriptomics data and generally rely upon a large number of shared features across datasets. Those methods are unsuitable when applied to single-cell proteomic datasets, due to the limited number of parameters simultaneously accessed, and the lack of shared markers across these experiments. Our algorithmic pipeline takes into account both shared and distinct features and consists of vital filtering steps to avoid sub-optimal matching. MARIO accurately matches and integrates data from different single-cell proteomic and multi-modal methods, including spatial techniques, and has cross-species capabilities. The rest parts are theoretical investigations of two important modules of the MARIO pipeline. The second part discusses minimax optimal community detection in a multi-layer stochastic block model. We characterize the minimax rate for estimating both the global and individualized community structures. We propose a spectral initialization + maximum a posteriori based refinement algorithm that enjoys minimax optimality. This algorithm serves as a key step in MARIO’s quality control steps. The third part is about minimax optimal estimation of a latent correspondence between two datasets where one is a noisy permuted version of the other
- Published
- 2022
26. Fast Remaining Capacity Estimation for Lithium‐ion Batteries Based on Short‐time Pulse Test and Gaussian Process Regression.
- Author
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Ran, Aihua, Cheng, Ming, Chen, Shuxiao, Liang, Zheng, Zhou, Zihao, Zhou, Guangmin, Kang, Feiyu, Zhang, Xuan, Li, Baohua, and Wei, Guodan
- Abstract
It remains challenging to effectively estimate the remaining capacity of the secondary lithium‐ion batteries that have been widely adopted for consumer electronics, energy storage, and electric vehicles. Herein, by integrating regular real‐time current short pulse tests with data‐driven Gaussian process regression algorithm, an efficient battery estimation has been successfully developed and validated for batteries with capacity ranging from 100% of the state of health (SOH) to below 50%, reaching an average accuracy as high as 95%. Interestingly, the proposed pulse test strategy for battery capacity measurement could reduce test time by more than 80% compared with regular long charge/discharge tests. The short‐term features of the current pulse test were selected for an optimal training process. Data at different voltage stages and state of charge (SOC) are collected and explored to find the most suitable estimation model. In particular, we explore the validity of five different machine‐learning methods for estimating capacity driven by pulse features, whereas Gaussian process regression with Matern kernel performs the best, providing guidance for future exploration. The new strategy of combining short pulse tests with machine‐learning algorithms could further open window for efficiently forecasting lithium‐ion battery remaining capacity. [ABSTRACT FROM AUTHOR]
- Published
- 2023
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27. Perception-Aware Receding Horizon Trajectory Planning for Multicopters With Visual-Inertial Odometry
- Author
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Wu, Xiangyu, primary, Chen, Shuxiao, additional, Sreenath, Koushil, additional, and Mueller, Mark W., additional
- Published
- 2022
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28. Erratum to “Berbamine Suppresses the Progression of Bladder Cancer by Modulating the ROS/NF-κB Axis”
- Author
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Han, Chenglin, primary, Wang, Zilong, additional, Chen, Shuxiao, additional, Li, Lin, additional, Xu, Yingkun, additional, Kang, Weiting, additional, Wei, Chunxiao, additional, Ma, Hongbin, additional, Wang, Muwen, additional, and Jin, Xunbo, additional
- Published
- 2021
- Full Text
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29. ADAM10 attenuates the development of abdominal aortic aneurysms in a mouse model
- Author
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Li Gang, Feng Xuedong, Wu Xuejun, Gao Peixian, Qiu Renfeng, Chen Shuxiao, Yuan Hai, and Luo Kun
- Subjects
Male ,Cancer Research ,Pathology ,medicine.medical_specialty ,high mobility group box 1 ,Receptor for Advanced Glycation End Products ,H&E stain ,ADAM metalloprotease domain 10 ,receptor for advanced glycosylation end products ,Protective Agents ,Biochemistry ,NF-κB ,Pathogenesis ,ADAM10 Protein ,Mice ,abdominal aortic aneurysm ,Aneurysm ,Genetics ,medicine ,Van Gieson's stain ,Animals ,cardiovascular diseases ,HMGB1 Protein ,Molecular Biology ,Pancreatic elastase ,biology ,business.industry ,NF-kappa B ,Membrane Proteins ,Articles ,medicine.disease ,Abdominal aortic aneurysm ,Mice, Inbred C57BL ,Oncology ,cardiovascular system ,biology.protein ,Molecular Medicine ,Immunohistochemistry ,Amyloid Precursor Protein Secretases ,business ,Elastin ,Aortic Aneurysm, Abdominal - Abstract
An abdominal aortic aneurysm (AAA) is a life‑threatening disease associated with a high mortality rate. At present, surgery or minimally invasive interventions are used in clinical treatment, especially for small aneurysms. However, the benefits of surgical repair are not obvious, and AAA ruptures can be prevented by aneurysm therapy to inhibit the growth of small aneurysms. Therefore, evaluating effective drugs to treat small AAAs is urgently required. Chronic inflammation is the main pathological feature of aneurysmal tissues. The aim of the present study was to investigate the protective role and underlying mechanism of ADAM metallopeptidase domain 10 (ADAM10). In the present study, a mouse model of AAA was established via porcine pancreatic elastase perfusion for 5 min per day for 14 days. ADAM10 (6 mg/kg) was injected intraperitoneally following 3 days of porcine pancreatic elastase perfusion in the ADAM10 group and the treatment continued for 10 days. The maximum inner luminal diameters of the infrarenal abdominal aortas were measured using an animal ultrasound system. The levels of high mobility group box 1 (HMGB1) and soluble receptor for advanced glycosylation end products in serum samples were measured by ELISA. Hematoxylin and eosin and elastin van Gieson staining were performed to observe morphology, integrity of the elastin layers and elastin degradation. CD68 expression was detected by immunohistochemical staining. Reverse transcription‑quantitative PCR and western blotting were used for detection of mRNA and protein levels. The gelatinolytic activities of MMP‑2 and MMP‑9 were quantified via gelatin zymography analysis. These results showed that ADAM10 inhibited HMGB1/RAGE/NF‑κB signaling and MMP activity in the pathogenesis of pancreatic elastase‑induced AAA, which provide insight into the molecular mechanism of AAA and suggested that ADAM10 may be a potential therapeutic target for AAA.
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- 2021
30. Betanin Prevents Experimental Abdominal Aortic Aneurysm Progression by Modulating the TLR4/NF-κB and Nrf2/HO-1 Pathways
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Qiu, Renfeng, primary, Chen, Shuxiao, additional, Hua, Fang, additional, Bian, Shuai, additional, Chen, Jianfeng, additional, Li, Gang, additional, and Wu, Xuejun, additional
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- 2021
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31. Low-temperature synthesis of multilayer graphene/amorphous carbon hybrid films and their potential application in solar cells
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Cui, Tongxiang, Lv, Ruitao, Huang, Zheng-Hong, Zhu, Hongwei, Jia, Yi, Chen, Shuxiao, Wang, Kunlin, Wu, Dehai, and Kang, Feiyu
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- 2012
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32. RPN2 Predicts Poor Prognosis and Promotes Bladder Cancer Growth and Metastasis via the PI3K-Akt Pathway
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Han,Chenglin, Chen,Shuxiao, Ma,Haiyang, Wen,Xiangchuan, Wang,Zilong, Xu,Yingkun, Jin,Xunbo, Yu,Xiao, Wang,Muwen, Han,Chenglin, Chen,Shuxiao, Ma,Haiyang, Wen,Xiangchuan, Wang,Zilong, Xu,Yingkun, Jin,Xunbo, Yu,Xiao, and Wang,Muwen
- Abstract
Chenglin Han,1 Shuxiao Chen,2 Haiyang Ma,3 Xiangchuan Wen,4 Zilong Wang,1 Yingkun Xu,1 Xunbo Jin,1,5 Xiao Yu,5 Muwen Wang1,5 1Department of Urology, Shandong Provincial Hospital, Cheeloo College of Medicine, Shandong University, Jinan, Shandong, People’s Republic of China; 2Department of Vascular Surgery, Shandong Provincial Hospital, Cheeloo College of Medicine, Shandong University, Jinan, Shandong, People’s Republic of China; 3Department of Thoracic Surgery, Shandong Provincial Hospital, Cheeloo College of Medicine, Shandong University, Jinan, Shandong, People’s Republic of China; 4Department of Neurology, Shandong Provincial Hospital, Cheeloo College of Medicine, Shandong University, Jinan, Shandong, People’s Republic of China; 5Department of Urology, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, Shandong, People’s Republic of ChinaCorrespondence: Xiao YuDepartment of Urology, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jingwu Road, Huaiyin District, Jinan City, Shandong Province, People’s Republic of ChinaTel +86-15168889682Email surgeonyuxiao@126.comMuwen WangDepartment of Urology, Shandong Provincial Hospital, Cheeloo College of Medicine, Shandong University, 9677 Jingshidong Road, Jinan City, Shandong Province, People’s Republic of ChinaTel +86-15168886899Email docwmw1@163.comBackground: Ribophorin II (RPN2) is a highly conserved glycoprotein involved in the N-linked glycosylation of multiple proteins. RPN2 was reported to be associated with malignant phenotype in several tumors. However, the function of RPN2 in bladder cancer (BCa) remains unclear.Methods: Expression of RPN2 in BCa and adjacent tissues was compared by bioinformatics analysis, immunohistochemistry, and Western blotting. qRT-PCR was performed to explore the correlation between RPN2 expression and various clinical features in 38 patients. We assessed the
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- 2021
33. Chemerin-9 Attenuates Experimental Abdominal Aortic Aneurysm Formation in ApoE−/− Mice
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Chen, Shuxiao, primary, Han, Chenglin, additional, Bian, Shuai, additional, Chen, Jianfeng, additional, Feng, Xuedong, additional, Li, Gang, additional, and Wu, Xuejun, additional
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- 2021
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34. RPN2 Predicts Poor Prognosis and Promotes Bladder Cancer Growth and Metastasis via the PI3K-Akt Pathway
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Han, Chenglin, primary, Chen, Shuxiao, additional, Ma, Haiyang, additional, Wen, Xiangchuan, additional, Wang, Zilong, additional, Xu, Yingkun, additional, Jin, Xunbo, additional, Yu, Xiao, additional, and Wang, Muwen, additional
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- 2021
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35. Roles of Reactive Oxygen Species in Biological Behaviors of Prostate Cancer
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Han, Chenglin, Wang, Zilong, Xu, Yingkun, Chen, Shuxiao, Han, Yuqing, Li, Lin, Wang, Muwen, and Jin, Xunbo
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Article Subject - Abstract
Prostate cancer (PCa), known as a heterogenous disease, has a high incidence and mortality rate around the world and seriously threatens public health. As an inevitable by-product of cellular metabolism, reactive oxygen species (ROS) exhibit beneficial effects by regulating signaling cascades and homeostasis. More and more evidence highlights that PCa is closely associated with age, and high levels of ROS are driven through activation of several signaling pathways with age, which facilitate the initiation, development, and progression of PCa. Nevertheless, excessive amounts of ROS result in harmful effects, such as genotoxicity and cell death. On the other hand, PCa cells adaptively upregulate antioxidant genes to detoxify from ROS, suggesting that a subtle balance of intracellular ROS levels is required for cancer cell functions. The current review discusses the generation and biological roles of ROS in PCa and provides new strategies based on the regulation of ROS for the treatment of PCa.
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- 2020
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36. Berbamine Suppresses the Progression of Bladder Cancer by Modulating the ROS/NF-κB Axis
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Han, Chenglin, primary, Wang, Zilong, additional, Chen, Shuxiao, additional, Li, Lin, additional, Xu, Yingkun, additional, Kang, Weiting, additional, Wei, Chunxiao, additional, Ma, Hongbin, additional, Wang, Muwen, additional, and Jin, Xunbo, additional
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- 2021
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37. A gradient screening approach for retired lithium-ion batteries based on X-ray computed tomography images
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Ran, Aihua, primary, Chen, Shuxiao, additional, Zhang, Siwei, additional, Liu, Siyang, additional, Zhou, Zihao, additional, Nie, Pengbo, additional, Qian, Kun, additional, Fang, Lu, additional, Zhao, Shi-Xi, additional, Li, Baohua, additional, Kang, Feiyu, additional, Zhou, Xiang, additional, Sun, Hongbin, additional, Zhang, Xuan, additional, and Wei, Guodan, additional
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- 2020
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38. Rapid tracking of extrinsic projector parameters in fringe projection using machine learning
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Stavroulakis, Petros, Chen, Shuxiao, Delorme, Clement, Bointon, Patrick, Tzimiropoulos, Georgios, and Leach, Richard
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Mechanical Engineering ,Electrical and Electronic Engineering ,Atomic and Molecular Physics, and Optics ,Electronic, Optical and Magnetic Materials - Abstract
In this work, we propose to enable the angular re-orientation of a projector within a fringe projection system in real-time without the need for re-calibrating the system. The estimation of the extrinsic orientation parameters of the projector is performed using a convolutional neural network and images acquired from the camera in the setup. The convolutional neural network was trained to classify the azimuth and elevation angles of the projector approximated by a point source through shadow images of the measured object. The images used to train the neural network were generated through the use of CAD rendering, by simulating the illumination of the object model from different directions and then rendering an image of its shadow. The accuracy to which the azimuth and elevation angles are estimated is within 1 classification bin, where 1 bin is designated as a ±10° patch of the illumination dome. To evaluate use of the proposed system in fringe projection, a pyramidal additively manufactured object was measured. The point clouds generated using the proposed method were compared to those obtained by an established fringe projection calibration method. The maximum dimensional error in the point cloud generated when using the convolutional network as compared to the established calibration method for the object measured was found to be 1.05 mm on average.
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- 2019
39. Fine-tuning the Cross-Sectional Architecture of Antimony-doped Tin Oxide Nanofibers as Pt Catalyst Support for Enhanced Oxygen Reduction Activity
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Chen, Shuxiao, Du, Hongda, Wei, Yinping, Peng, Lingyi, Li, Yadong, Gan, Lin, and Kang, Feiyu
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- 2017
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40. Chemerin-9 Attenuates Experimental Abdominal Aortic Aneurysm Formation in ApoE−/− Mice.
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Chen, Shuxiao, Han, Chenglin, Bian, Shuai, Chen, Jianfeng, Feng, Xuedong, Li, Gang, and Wu, Xuejun
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- *
ABDOMINAL aortic aneurysms , *CROHN'S disease , *CHEMERIN , *AORTIC rupture , *SMOOTH muscle , *ADIPOSE tissues , *MUSCLE cells - Abstract
Chronic inflammation plays an essential role in the pathogenesis of abdominal aortic aneurysm (AAA), a progressive segmental abdominal aortic dilation. Chemerin, a multifunctional adipocytokine, is mainly generated in the liver and adipose tissue. The combination of chemerin and chemokine-like receptor 1 (CMKLR1) has been demonstrated to promote the progression of atherosclerosis, arthritis diseases, and Crohn's disease. However, chemerin-9 acts as an analog of chemerin to exert an anti-inflammatory effect by binding to CMKLR1. Here, we first demonstrated that AAA exhibited higher levels of chemerin and CMKLR1 expression compared with the normal aortic tissues. Hence, we hypothesized that the chemerin/CMKLR1 axis might be involved in AAA progression. Moreover, we found that chemerin-9 treatment markedly suppressed inflammatory cell infiltration, neovascularization, and matrix metalloproteinase (MMP) expression, while increasing the elastic fibers and smooth muscle cells (SMCs) in Ang II-induced AAA in ApoE−/− mice. This demonstrated that chemerin-9 could inhibit AAA formation. Collectively, our findings indicate a potential mechanism underlying AAA progression and suggest that chemerin-9 can be used therapeutically. [ABSTRACT FROM AUTHOR]
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- 2021
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41. A Group-Theoretic Framework for Data Augmentation.
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Chen, Shuxiao, Dobriban, Edgar, and Lee, Jane H.
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- *
DATA augmentation , *DATA distribution - Abstract
Data augmentation is a widely used trick when training deep neural networks: in addition to the original data, properly transformed data are also added to the training set. However, to the best of our knowledge, a clear mathematical framework to explain the performance benefits of data augmentation is not available. In this paper, we develop such a theoretical framework. We show data augmentation is equivalent to an averaging operation over the orbits of a certain group that keeps the data distribution approximately invariant. We prove that it leads to variance reduction. We study empirical risk minimization, and the examples of exponential families, linear regression, and certain two-layer neural networks. We also discuss how data augmentation could be used in problems with symmetry where other approaches are prevalent, such as in cryo-electron microscopy (cryo-EM). [ABSTRACT FROM AUTHOR]
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- 2020
42. Label-aware neural tangent kernel: Toward better generalization and local elasticity
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Chen, Shuxiao, He, Hangfeng, and Su, Weijie J.
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FOS: Computer and information sciences ,Computer Science - Machine Learning ,Statistics - Machine Learning ,Computer Science::Neural and Evolutionary Computation ,Machine Learning (stat.ML) ,Machine Learning (cs.LG) - Abstract
As a popular approach to modeling the dynamics of training overparametrized neural networks (NNs), the neural tangent kernels (NTK) are known to fall behind real-world NNs in generalization ability. This performance gap is in part due to the \textit{label agnostic} nature of the NTK, which renders the resulting kernel not as \textit{locally elastic} as NNs~\citep{he2019local}. In this paper, we introduce a novel approach from the perspective of \emph{label-awareness} to reduce this gap for the NTK. Specifically, we propose two label-aware kernels that are each a superimposition of a label-agnostic part and a hierarchy of label-aware parts with increasing complexity of label dependence, using the Hoeffding decomposition. Through both theoretical and empirical evidence, we show that the models trained with the proposed kernels better simulate NNs in terms of generalization ability and local elasticity., NeurIPS 2020 camera ready version, 32 pages, 2 figures, 3 tables
43. Cross-domain information fusion for enhanced cell population delineation in single-cell spatial-omics data.
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Zhu B, Gao S, Chen S, Yeung J, Bai Y, Huang AY, Yeo YY, Liao G, Mao S, Jiang ZG, Rodig SJ, Shalek AK, Nolan GP, Jiang S, and Ma Z
- Abstract
Cell population delineation and identification is an essential step in single-cell and spatial-omics studies. Spatial-omics technologies can simultaneously measure information from three complementary domains related to this task: expression levels of a panel of molecular biomarkers at single-cell resolution, relative positions of cells, and images of tissue sections, but existing computational methods for performing this task on single-cell spatial-omics datasets often relinquish information from one or more domains. The additional reliance on the availability of "atlas" training or reference datasets limits cell type discovery to well-defined but limited cell population labels, thus posing major challenges for using these methods in practice. Successful integration of all three domains presents an opportunity for uncovering cell populations that are functionally stratified by their spatial contexts at cellular and tissue levels: the key motivation for employing spatial-omics technologies in the first place. In this work, we introduce Cell Spatio- and Neighborhood-informed Annotation and Patterning (CellSNAP), a self-supervised computational method that learns a representation vector for each cell in tissue samples measured by spatial-omics technologies at the single-cell or finer resolution. The learned representation vector fuses information about the corresponding cell across all three aforementioned domains. By applying CellSNAP to datasets spanning both spatial proteomic and spatial transcriptomic modalities, and across different tissue types and disease settings, we show that CellSNAP markedly enhances de novo discovery of biologically relevant cell populations at fine granularity, beyond current approaches, by fully integrating cells' molecular profiles with cellular neighborhood and tissue image information., Competing Interests: CONFLICT OF INTERESTS S.J. is a co-founder of Elucidate Bio Inc, has received speaking honorariums from Cell Signaling Technology, and has received research support from Roche unrelated to this work. G.P.N. received research grants from Pfizer, Inc.; Vaxart, Inc.; Celgene, Inc.; and Juno Therapeutics, Inc. during the time of and unrelated to this work. G.P.N. is a co-founder of Akoya Biosciences, Inc. and of Ionpath Inc., inventor on patent US9909167, and is a Scientific Advisory Board member for Akoya Biosciences, Inc. A.K.S. reports compensation for consulting and/or scientific advisory board membership from Honeycomb Biotechnologies, Cellarity, Ochre Bio, Relation Therapeutics, IntrECate Biotherapeutics, Bio-Rad Laboratories, Fog pharma, Passkey Therapeutics, and Dahlia Biosciences unrelated to this work. S.J.R. receives research support from Bristol-Myers-Squibb and KITE/Gilead. S.J.R. is a member of the SAB of Immunitas Therapeutics. The other authors declare no competing interests.
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- 2024
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44. Integration of spatial and single-cell data across modalities with weak linkage.
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Chen S, Zhu B, Huang S, Hickey JW, Lin KZ, Snyder M, Greenleaf WJ, Nolan GP, Zhang NR, and Ma Z
- Abstract
single-cell sequencing methods have enabled the profiling of multiple types of molecular readouts at cellular resolution, and recent developments in spatial barcoding, in situ hybridization, and in situ sequencing allow such molecular readouts to retain their spatial context. Since no technology can provide complete characterization across all layers of biological modalities within the same cell, there is pervasive need for computational cross-modal integration (also called diagonal integration) of single-cell and spatial omics data. For current methods, the feasibility of cross-modal integration relies on the existence of highly correlated, a priori "linked" features. When such linked features are few or uninformative, a scenario that we call "weak linkage", existing methods fail. We developed MaxFuse, a cross-modal data integration method that, through iterative co-embedding, data smoothing, and cell matching, leverages all information in each modality to obtain high-quality integration. MaxFuse is modality-agnostic and, through comprehensive benchmarks on single-cell and spatial ground-truth multiome datasets, demonstrates high robustness and accuracy in the weak linkage scenario. A prototypical example of weak linkage is the integration of spatial proteomic data with single-cell sequencing data. On two example analyses of this type, we demonstrate how MaxFuse enables the spatial consolidation of proteomic, transcriptomic and epigenomic information at single-cell resolution on the same tissue section.
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- 2023
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45. Minimax Estimation for Personalized Federated Learning: An Alternative between FedAvg and Local Training?
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Chen S, Zheng Q, Long Q, and Su WJ
- Abstract
A widely recognized difficulty in federated learning arises from the statistical heterogeneity among clients: local datasets often originate from distinct yet not entirely unrelated probability distributions, and personalization is, therefore, necessary to achieve optimal results from each individual's perspective. In this paper, we show how the excess risks of personalized federated learning using a smooth, strongly convex loss depend on data heterogeneity from a minimax point of view, with a focus on the FedAvg algorithm (McMahan et al., 2017) and pure local training (i.e., clients solve empirical risk minimization problems on their local datasets without any communication). Our main result reveals an approximate alternative between these two baseline algorithms for federated learning: the former algorithm is minimax rate optimal over a collection of instances when data heterogeneity is small, whereas the latter is minimax rate optimal when data heterogeneity is large, and the threshold is sharp up to a constant. As an implication, our results show that from a worst-case point of view, a dichotomous strategy that makes a choice between the two baseline algorithms is rate-optimal. Another implication is that the popular FedAvg following by local fine tuning strategy is also minimax optimal under additional regularity conditions. Our analysis relies on a new notion of algorithmic stability that takes into account the nature of federated learning.
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- 2023
46. Erratum to "Berbamine Suppresses the Progression of Bladder Cancer by Modulating the ROS/NF- κ B Axis".
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Han C, Wang Z, Chen S, Li L, Xu Y, Kang W, Wei C, Ma H, Wang M, and Jin X
- Abstract
[This corrects the article DOI: 10.1155/2021/8851763.]., (Copyright © 2021 Chenglin Han et al.)
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- 2021
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47. Federated f -Differential Privacy.
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Zheng Q, Chen S, Long Q, and Su WJ
- Abstract
Federated learning (FL) is a training paradigm where the clients collaboratively learn models by repeatedly sharing information without compromising much on the privacy of their local sensitive data. In this paper, we introduce federated f-differential privacy , a new notion specifically tailored to the federated setting, based on the framework of Gaussian differential privacy. Federated f -differential privacy operates on record level : it provides the privacy guarantee on each individual record of one client's data against adversaries. We then propose a generic private federated learning framework PriFedSync that accommodates a large family of state-of-the-art FL algorithms, which provably achieves federated f -differential privacy. Finally, we empirically demonstrate the trade-off between privacy guarantee and prediction performance for models trained by PriFedSync in computer vision tasks.
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- 2021
48. Berbamine Suppresses the Progression of Bladder Cancer by Modulating the ROS/NF- κ B Axis.
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Han C, Wang Z, Chen S, Li L, Xu Y, Kang W, Wei C, Ma H, Wang M, and Jin X
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- Animals, Cell Line, Tumor, Humans, Mice, Mice, Nude, Urinary Bladder Neoplasms drug therapy, Urinary Bladder Neoplasms pathology, Benzylisoquinolines pharmacokinetics, NF-kappa B metabolism, Neoplasm Proteins metabolism, Reactive Oxygen Species metabolism, Signal Transduction drug effects, Urinary Bladder Neoplasms metabolism
- Abstract
Berbamine (BBM), one of the bioactive ingredients extracted from Berberis plants, has attracted intensive attention because of its significant antitumor activity against various malignancies. However, the exact role and potential molecular mechanism of berbamine in bladder cancer (BCa) remain unclear. In the present study, our results showed that berbamine inhibited cell viability, colony formation, and proliferation. Additionally, berbamine induced cell cycle arrest at S phase by a synergistic mechanism involving stimulation of P21 and P27 protein expression as well as downregulation of CyclinD, CyclinA2, and CDK2 protein expression. In addition to suppressing epithelial-mesenchymal transition (EMT), berbamine rearranged the cytoskeleton to inhibit cell metastasis. Mechanistically, the expression of P65, P-P65, and P-I κ B α was decreased upon berbamine treatment, yet P65 overexpression abrogated the effects of berbamine on the proliferative and metastatic potential of BCa cells, which indicated that berbamine attenuated the malignant biological activities of BCa cells by inhibiting the NF- κ B pathway. More importantly, berbamine increased the intracellular reactive oxygen species (ROS) level through the downregulation of antioxidative genes such as Nrf2, HO-1, SOD2, and GPX-1. Following ROS accumulation, the intrinsic apoptotic pathway was triggered by an increase in the ratio of Bax/Bcl-2. Furthermore, berbamine-mediated ROS accumulation negatively regulated the NF- κ B pathway to a certain degree. Consistent with our in vitro results, berbamine successfully inhibited tumor growth and blocked the NF- κ B pathway in our xenograft model. To summarize, our data demonstrated that berbamine exerts antitumor effects via the ROS/NF- κ B signaling axis in bladder cancer, which provides a basis for further comprehensive study and presents a potential candidate for clinical treatment strategies against bladder cancer., Competing Interests: All authors declare that they have no conflicts of interest related to this paper., (Copyright © 2021 Chenglin Han et al.)
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- 2021
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