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2. Changing epidemiology and viral interplay of hepatitis B, C and D among injecting drug user-dominant prisoners in Taiwan

Author

Lu, Ming-Ying, Chen, Chun-Ting, Shih, Yu-Lueng, Tsai, Pei-Chien, Hsieh, Meng-Hsuan, Huang, Chung-Feng, Yeh, Ming-Lun, Huang, Ching-I, Wang, Shu-Chi, Tsai, Yi-Shan, Ko, Yu-Min, Lin, Ching-Chih, Chen, Kuan-Yu, Wei, Yu-Ju, Hsu, Po-Yao, Hsu, Cheng-Ting, Jang, Tyng-Yuan, Liu, Ta-Wei, Liang, Po-Cheng, Hsieh, Ming-Yen, Lin, Zu-Yau, Chen, Shinn-Cherng, Huang, Jee-Fu, Dai, Chia-Yen, Chuang, Wan-Long, Yu, Ming-Lung, and Chang, Wen-Yu

Published
2021
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3. Role of hepatitis D virus infection in development of hepatocellular carcinoma among chronic hepatitis B patients treated with nucleotide/nucleoside analogues

Author

Jang, Tyng-Yuan, Wei, Yu-Ju, Liu, Ta-Wei, Yeh, Ming-Lun, Liu, Shu-Fen, Hsu, Cheng-Ting, Hsu, Po-Yao, Lin, Yi-Hung, Liang, Po-Cheng, Hsieh, Meng-Hsuan, Ko, Yu-Min, Tsai, Yi-Shan, Chen, Kuan-Yu, Lin, Ching-Chih, Tsai, Pei-Chien, Wang, Shu-Chi, Huang, Ching-I., Lin, Zu-Yau, Chen, Shinn-Cherng, Chuang, Wan-Long, Huang, Jee-Fu, Dai, Chia-Yen, Huang, Chung-Feng, and Yu, Ming-Lung

Published
2021
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7. Artificial intelligence based on serum biomarkers predicts the efficacy of lenvatinib for unresectable hepatocellular carcinoma

Author

Po-Yao Hsu, Liang, Po-Cheng, Chang, Wen-Tsan, Lu, Ming-Ying, Wang, Wen-Hsuan, Chuang, Shih-Chang, Wei, Yu-Ju, Jang, Tyng-Yuan, Yeh, Ming-Lun, Huang, Ching-I, Lin, Yi-Hung, Wang, Chih-Wen, Hsieh, Ming-Yen, Hou, Nai-Jen, Hsieh, Meng-Hsuan, Tsai, Yi-Shan, Ko, Yu-Min, Lin, Ching-Chih, Chen, Kuan-Yu, Dai, Chia-Yen, Lin, Zu-Yau, Chen, Shinn-Cherng, Chuang, Wan-Long, Huang, Chung-Feng, Huang, Jee-Fu, and Yu, Ming-Lung

Subjects
Original Article
Abstract

Lenvatinib has been effective not only as a first-line but also as a later-line systemic therapy for unresectable hepatocellular carcinoma (uHCC) in real-world clinical practice. How to predict the efficacy of lenvatinib and guide appropriate therapy selection in patients with uHCC have become important issues. This study aimed to investigate the impact of serum biomarkers on the treatment outcomes of patients with uHCC treated with lenvatinib in a real-world setting using an artificial intelligence algorithm. We measured serum biomarkers, including alpha-fetoprotein (AFP), albumin-bilirubin (ALBI) grade, and circulating angiogenic factors (CAFs [i.e., vascular endothelial growth factor, angiopoietin-2, fibroblast growth factor-19 [FGF19], and FGF21]) and analyzed treatment outcomes, including objective response rate (ORR), progression-free survival (PFS), and overall survival (OS) in patients with uHCC treated with lenvatinib. The results of this study demonstrated that an AFP reduction ≥ 40% from baseline within 8 weeks after lenvatinib induction was associated with a higher ORR. With baseline biomarkers using a decision tree-based model, we identified patients with high, intermediate, and low ORRs (84.6%, 21.7% and 0%, respectively; odds ratio, 53.04, P < 0.001, high versus intermediate/low groups). Based on the decision tree-based survival predictive model, baseline AFP was the most important factor for OS, followed by ALBI grade and FGF21.

Published
2022

9. Circulating Let-7 Family Members as Non-Invasive Biomarkers for Predicting Hepatocellular Carcinoma Risk after Antiviral Treatment among Chronic Hepatitis C Patients

Author

Tsai, Yi-Shan, primary, Huang, Ching-I, additional, Tsai, Pei-Chien, additional, Yeh, Ming-Lun, additional, Huang, Chung-Feng, additional, Hsieh, Meng-Hsuan, additional, Liu, Ta-Wei, additional, Lin, Yi-Hung, additional, Liang, Po-Cheng, additional, Lin, Zu-Yau, additional, Chen, Shinn-Cherng, additional, Huang, Jee-Fu, additional, Chuang, Wan-Long, additional, Dai, Chia-Yen, additional, and Yu, Ming-Lung, additional

Published
2022
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11. Dynamics of cytokines predicts risk of hepatocellular carcinoma among chronic hepatitis C patients after viral eradication

Author

Lu, Ming-Ying, primary, Yeh, Ming-Lun, additional, Huang, Ching-I, additional, Wang, Shu-Chi, additional, Tsai, Yi-Shan, additional, Tsai, Pei-Chien, additional, Ko, Yu-Min, additional, Lin, Ching-Chih, additional, Chen, Kuan-Yu, additional, Wei, Yu-Ju, additional, Hsu, Po-Yao, additional, Hsu, Cheng-Ting, additional, Jang, Tyng-Yuan, additional, Liu, Ta-Wei, additional, Liang, Po-Cheng, additional, Hsieh, Ming-Yen, additional, Lin, Zu-Yau, additional, Chen, Shinn-Cherng, additional, Huang, Chung-Feng, additional, Huang, Jee-Fu, additional, Dai, Chia-Yen, additional, Chuang, Wan-Long, additional, and Yu, Ming-Lung, additional

Published
2022
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14. Regorafenib for Taiwanese patients with unresectable hepatocellular carcinoma after sorafenib failure: Impact of alpha‐fetoprotein levels

Author

Hsu, Po‐Yao, primary, Cheng, Tzu‐Sheng, additional, Chuang, Shih‐Chang, additional, Chang, Wen‐Tsan, additional, Liang, Po‐Cheng, additional, Hsu, Cheng‐Ting, additional, Wei, Yu‐Ju, additional, Jang, Tyng‐Yuan, additional, Yeh, Ming‐Lun, additional, Huang, Ching‐I, additional, Lin, Yi‐Hung, additional, Wang, Chih‐Wen, additional, Hsieh, Ming‐Yen, additional, Hou, Nai‐Jen, additional, Hsieh, Meng‐Hsuan, additional, Tsai, Yi‐Shan, additional, Ko, Yu‐Min, additional, Lin, Ching‐Chih, additional, Chen, Kuan‐Yu, additional, Dai, Chia‐Yen, additional, Lin, Zu‐Yau, additional, Chen, Shinn‐Cherng, additional, Huang, Jee‐Fu, additional, Chuang, Wan‐Long, additional, Huang, Chung‐Feng, additional, and Yu, Ming‐Lung, additional

Published
2021
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22. Genotype distribution, clinical characteristics, and racial differences observed in chronic hepatitis C patients in Pingtung, Taiwan

Author

Jang, Tyng-Yuan, primary, Liang, Po-Cheng, additional, Liu, Ta-Wei, additional, Wei, Yu-Ju, additional, Yeh, Ming-Lun, additional, Hsu, Cheng-Ting, additional, Hsu, Po-Yao, additional, Lin, Yi-Hung, additional, Hsieh, Meng-Hsuan, additional, Huang, Ching-I, additional, Huang, Chung-Feng, additional, Lin, Zu-Yau, additional, Chen, Shinn-Cherng, additional, Huang, Jee-Fu, additional, Dai, Chia-Yen, additional, Yu, Ming-Lung, additional, and Chuang, Wan-Long, additional

Published
2021
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23. Concordance of SVR12, SVR24 and SVR durability in Taiwanese chronic hepatitis C patients with direct-acting antivirals

Author

Lin, Chuan-Pin, primary, Liang, Po-Cheng, additional, Huang, Ching-I, additional, Yeh, Ming-Lun, additional, Hsu, Po-Yao, additional, Hsu, Cheng-Ting, additional, Wei, Yu-Ju, additional, Liu, Ta-Wei, additional, Hsieh, Ming-Yen, additional, Hou, Nai-Jen, additional, Jang, Tyng-Yuang, additional, Lin, Yi-Hung, additional, Wang, Chih-Wen, additional, Lin, Zu-Yau, additional, Chen, Shinn-Cherng, additional, Huang, Chung-Feng, additional, Huang, Jee-Fu, additional, Dai, Chia-Yen, additional, Chuang, Wan-Long, additional, and Yu, Ming-Lung, additional

Published
2021
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25. Scaling up the in-hospital hepatitis C virus care cascade in Taiwan

Author

Huang, Chung-Feng, primary, Wu, Pey-Fang, additional, Yeh, Ming-Lun, additional, Huang, Ching-I, additional, Liang, Po-Cheng, additional, Hsu, Cheng-Ting, additional, Hsu, Po-Yao, additional, Liu, Hung-Yin, additional, Huang, Ying-Chou, additional, Lin, Zu-Yau, additional, Chen, Shinn-Cherng, additional, Huang, Jee-Fu, additional, Dai, Chia-Yen, additional, Chuang, Wan-Long, additional, and Yu, Ming-Lung, additional

Published
2021
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26. Comedications and potential drug-drug interactions with direct-acting antivirals in hepatitis C patients on hemodialysis

Author

Hsu, Po-Yao, primary, Wei, Yu-Ju, additional, Lee, Jia-Jung, additional, Niu, Sheng-Wen, additional, Huang, Jiun-Chi, additional, Hsu, Cheng-Ting, additional, Jang, Tyng-Yuan, additional, Yeh, Ming-Lun, additional, Huang, Ching-I, additional, Liang, Po-Cheng, additional, Lin, Yi-Hung, additional, Hsieh, Ming-Yen, additional, Hsieh, Meng-Hsuan, additional, Chen, Szu-Chia, additional, Dai, Chia-Yen, additional, Lin, Zu-Yau, additional, Chen, Shinn-Cherng, additional, Huang, Jee-Fu, additional, Chang, Jer-Ming, additional, Hwang, Shang-Jyh, additional, Chuang, Wan-Long, additional, Huang, Chung-Feng, additional, Chiu, Yi-Wen, additional, and Yu, Ming-Lung, additional

Published
2021
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27. Role of hepatitis D virus in persistent alanine aminotransferase abnormality among chronic hepatitis B patients treated with nucleotide/nucleoside analogues

Author

Jang, Tyng-Yuan, primary, Wei, Yu-Ju, additional, Yeh, Ming-Lun, additional, Liu, Shu-Fen, additional, Hsu, Cheng-Ting, additional, Hsu, Po-Yao, additional, Liu, Ta-Wei, additional, Lin, Yi-Hung, additional, Liang, Po-Cheng, additional, Hsieh, Meng-Hsuan, additional, Ko, Yu-Min, additional, Tsai, Yi-Shan, additional, Chen, Kuan-Yu, additional, Lin, Ching-Chih, additional, Tsai, Pei-Chien, additional, Wang, Shu-Chi, additional, Huang, Ching-I., additional, Lin, Zu-Yau, additional, Chen, Shinn-Cherng, additional, Chuang, Wan-Long, additional, Huang, Jee-Fu, additional, Dai, Chia-Yen, additional, Huang, Chung-Feng, additional, and Yu, Ming-Lung, additional

Published
2021
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29. The applicability of non-invasive methods for assessing liver fibrosis in hemodialysis patients with chronic hepatitis C

Author

Lee, Jia-Jung, primary, Wei, Yu-Ju, additional, Lin, Ming-Yen, additional, Niu, Sheng-Wen, additional, Hsu, Po-Yao, additional, Huang, Jiun-Chi, additional, Jang, Tyng-Yuan, additional, Yeh, Ming-Lun, additional, Huang, Ching-I, additional, Liang, Po-Cheng, additional, Lin, Yi-Hung, additional, Hsieh, Ming-Yen, additional, Hsieh, Meng-Hsuan, additional, Chen, Szu-Chia, additional, Dai, Chia-Yen, additional, Lin, Zu-Yau, additional, Chen, Shinn-Cherng, additional, Huang, Jee-Fu, additional, Chang, Jer-Ming, additional, Hwang, Shang-Jyh, additional, Huang, Chung-Feng, additional, Chiu, Yi-Wen, additional, Chuang, Wan-Long, additional, and Yu, Ming-Lung, additional

Published
2020
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30. Real‐world effectiveness of direct‐acting antiviral agents for chronic hepatitis C patients with genotype‐2 infection after completed treatment

Author

Cheng, Tzu‐Sheng, primary, Liang, Po‐Cheng, additional, Huang, Chung‐Feng, additional, Yeh, Ming‐Lun, additional, Huang, Ching‐I, additional, Lin, Zu‐Yau, additional, Chen, Shinn‐Cherng, additional, Huang, Jee‐Fu, additional, Dai, Chia‐Yen, additional, Hsieh, Ping‐Hsin, additional, Chuang, Wan‐Long, additional, and Yu, Ming‐Lung, additional

Published
2020
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31. Limited sorafenib anticancer effects on primary cultured hepatocellular carcinoma cells with high NANOG expression.

Author

Lin, Zu‐Yau, Yeh, Ming‐Lun, Huang, Ching‐I, Chen, Shinn‐Cherng, Huang, Chung‐Feng, Huang, Jee‐Fu, Dai, Chia‐Yen, Yu, Ming‐Lung, and Chuang, Wan‐Long

Subjects
SORAFENIB, HEPATOCELLULAR carcinoma, ANTINEOPLASTIC agents, CANCER stem cells, INHIBITION of cellular proliferation, PARENTAL influences
Abstract

Cancer stem cell is considered as an important cause to exacerbate the prognosis. NANOG and POU5F1 are markers for cancer stem cells. The associations between NANOG and POU5F1 expressions with the sorafenib anticancer effects in primary cultured hepatocellular carcinoma (HCC) cells were investigated. Eight primary cultured HCC parent cell lines and 13 subgroups established by flow cytometric sorting using NANOG and POU5F1 as targets were investigated with clinically achievable sorafenib plasma concentrations (5 and 10 μg/mL). Sorafenib showed obvious downregulation of RAF/MEK/ERK signaling pathways and dose‐dependent anti‐proliferative effects only on s003 parent cell line, which showed the lowest expression of NANOG among all tested cell lines except one downregulated NANOG with upregulated POU5F1 s020 subgroup. Sorafenib also inhibited proliferation in this s020 subgroup but promoted proliferation in its parent cell line. For the only one downregulated NANOG alone s015 subgroup, sorafenib which had no influence on its parent cell line inhibited proliferation in this subgroup. Only the above three cell lines could demonstrate sorafenib antiproliferative effects. On the contrary, sorafenib promoted proliferation in three (s003, s015, s071) out of four upregulated NANOG alone subgroups. On the other hand, Sorafenib showed diverse influence on proliferation among four upregulated POU5F1 alone subgroups. In conclusion, NANOG rather than POU5F1 expression is a critical marker for the anticancer effects of sorafenib on HCC. The sorafenib anticancer effects on HCC cells with high NANOG expression were limited. Sorafenib should be combined with other drug able to target cancer cells with high NANOG expression. [ABSTRACT FROM AUTHOR]

Published
2022
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32. Clusters of Circulating let-7 Family Tumor Suppressors Are Associated with Clinical Characteristics of Chronic Hepatitis C

Author

Tsai, Yi-Shan, primary, Yeh, Ming-Lun, additional, Tsai, Pei-Chien, additional, Huang, Ching-I, additional, Huang, Chung-Feng, additional, Hsieh, Meng-Hsuan, additional, Liu, Ta-Wei, additional, Lin, Yi-Hung, additional, Liang, Po-Cheng, additional, Lin, Zu-Yau, additional, Chen, Shinn-Cherng, additional, Huang, Jee-Fu, additional, Chuang, Wan-Long, additional, Dai, Chia-Yen, additional, and Yu, Ming-Lung, additional

Published
2020
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33. Cure or curd: Modification of lipid profiles and cardio‐cerebrovascular events after hepatitis C virus eradication

Author

Huang, Chung‐Feng, primary, Dai, Chia‐Yen, additional, Yeh, Ming‐Lun, additional, Huang, Ching‐I, additional, Lee, Hsiang‐Chun, additional, Lai, Wen‐Ter, additional, Liang, Po‐Cheng, additional, Lin, Yi‐Hung, additional, Hsieh, Ming‐Yen, additional, Hou, Nai‐Jen, additional, Lin, Zu‐Yau, additional, Chen, Shinn‐Cherng, additional, Huang, Jee‐Fu, additional, Chuang, Wan‐Long, additional, and Yu, Ming‐Lung, additional

Published
2020
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34. Primary cultures of aspiration residual specimens predict outcomes of hepatocellular carcinoma patients receiving curative treatment

Author

Lin, Zu‐Yau, primary, Wang, Jing‐Houng, additional, Yeh, Ming‐Lun, additional, Huang, Ching‐I, additional, Kee, Kwong‐Ming, additional, Yen, Yi‐Hao, additional, Chen, Shinn‐Cherng, additional, Huang, Chung‐Feng, additional, Huang, Jee‐Fu, additional, Dai, Chia‐Yen, additional, Yu, Ming‐Lung, additional, and Chuang, Wan‐Long, additional

Published
2020
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35. Primary culture of aspiration residual specimens improves the diagnostic accuracy between hepatocellular carcinoma and benign nodules

Author

Lin, Zu‐Yau, primary, Wang, Jing‐Houng, additional, Yeh, Ming‐Lun, additional, Huang, Ching‐I, additional, Kee, Kwong‐Ming, additional, Yen, Yi‐Hao, additional, Chen, Shinn‐Cherng, additional, Huang, Chung‐Feng, additional, Huang, Jee‐Fu, additional, Dai, Chia‐Yen, additional, Yu, Ming‐Lung, additional, and Chuang, Wan‐Long, additional

Published
2020
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36. Tumor necrosis factor-[alpha] promoter polymorphism at position -308 predicts response to combination therapy in hepatitis C virus infection

Author

Dai, Chia-Yen, Chuang, Wan-Long, Chang, Wen-Yu, Chen, Shinn-Cherng, Lee, Li-Po, Hsieh, Ming-Yen, Hou, Nai-Jen, Lin, Zu-Yau, Huang, Jee-Fu, Hsieh, Ming-Yuh, Wang, Liang-Yen, and Yu, Ming-Lung

Subjects
Hepatitis C virus -- Research, Hepatitis C virus -- Health aspects, Hepatitis C virus -- Drug therapy, Interferon -- Dosage and administration, Ribavirin -- Dosage and administration, Health
Published
2006

37. Human leukocyte antigen class i and ii alleles and response to interferon-[alpha] treatment, in Taiwanese patients with chronic hepatitis C virus infection. (Brief Report)

Author

Yu, Ming-Lung, Dai, Chia-Yen, Chen, Shinn-Cherng, Chiu, Chao-Chin, Lee, Li-Pa, Lin, Zu-Yau, Hsieh, Ming-Yuh, Wang, Liang-Yen, Chuang, Wan-Lana, and Chang, Wen-Yu

Subjects
Liver cirrhosis -- Health aspects, Liver cirrhosis -- Prevention, Liver cirrhosis -- Care and treatment, Hepatitis C virus -- Health aspects, Leukocytes -- Physiological aspects, Interferon -- Physiological aspects, Immunogenetics -- Research, Patients -- Health aspects, Patients -- Care and treatment, Airborne infection -- Research, Airborne infection -- Causes of, Health
Published
2003

39. Real‐world effectiveness of direct‐acting antiviral agents for chronic hepatitis C patients with genotype‐2 infection after completed treatment.

Author

Cheng, Tzu‐Sheng, Liang, Po‐Cheng, Huang, Chung‐Feng, Yeh, Ming‐Lun, Huang, Ching‐I, Lin, Zu‐Yau, Chen, Shinn‐Cherng, Huang, Jee‐Fu, Dai, Chia‐Yen, Hsieh, Ping‐Hsin, Chuang, Wan‐Long, and Yu, Ming‐Lung

Subjects
CHRONIC hepatitis C, ANTIVIRAL agents, HEPATITIS C virus, HEPATITIS B virus, CHRONIC kidney failure
Abstract

Chronic hepatitis C (CHC) is a major cause of cirrhosis, hepatocellular carcinoma (HCC), and mortality. Eliminating hepatitis C virus (HCV) can greatly improve long‐term outcomes. Several direct‐acting antiviral agents (DAAs), including sofosbuvir (SOF) plus different NS5A inhibitors, as well as non‐SOF‐based DAAs, including glecaprevir/pibrentasvir (GLE/PIB), have been approved for treating CHC genotype‐2 (GT‐2) patients in Taiwan. However, there is limited real‐world effectiveness data regarding these different regimens. Thus, we aimed to evaluate the real‐world efficacy in CHC GT‐2 patients who underwent these DAA regimens. We retrospectively enrolled CHC GT‐2 patients who were treated with SOF‐based DAAs or GLE/PIB at a single medical center. A total of 704 enrolled patients were treated with either SOF + ribavirin (RBV), SOF/daclatasvir (DCV) ± RBV, SOF/ledipasvir (LDV) ± RBV, SOF/velpatasvir (VEL) ± RBV, or with GLE/PIB. The overall sustained virological response (SVR) rate was 97.9%. The SVR rate was significantly lower in the SOF + RBV group (95.6%) than in the non‐SOF + RBV (98.9%) group, especially compared to the SOF/DCV (100%) and GLE/PIB groups (99.5%). Among patients treated with SOF + RBV, cirrhotic patients had significantly lower SVR rates than noncirrhotic patients (89.4% vs 98.2%). Multivariate analysis showed that patients with a younger age, hepatitis B virus coinfection, baseline cirrhosis, or those who received SOF + RBV were less likely to achieve SVR. In conclusion, for CHC GT‐2 patients, SOF in combination with DCV, LDV, or VEL, as well as GLE/PIB, achieved similar high efficacies, regardless of cirrhosis, treatment experience, or chronic kidney disease status. Therefore, the use of DAA therapy to eradicate HCV should not be delayed in these populations. [ABSTRACT FROM AUTHOR]

Published
2021
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40. Equal treatment efficacy of direct-acting antivirals in patients with chronic hepatitis C and hepatocellular carcinoma? A prospective cohort study

Author

Huang, Chung-Feng, primary, Yeh, Ming-Lun, additional, Huang, Ching-I, additional, Liang, Po-Cheng, additional, Lin, Yi-Hung, additional, Hsieh, Ming-Yen, additional, Wei, Yu-Ju, additional, Lin, Zu-Yau, additional, Chen, Shinn-Cherng, additional, Huang, Jee-Fu, additional, Dai, Chia-Yen, additional, Chuang, Wan-Long, additional, and Yu, Ming-Lung, additional

Published
2019
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41. Elevated interleukin-4 levels predicted advanced fibrosis in chronic hepatitis C

Author

Batsaikhan, Batbold, primary, Lu, Ming-Ying, additional, Yeh, Ming-Lun, additional, Huang, Ching-I, additional, Huang, Chung-Feng, additional, Lin, Zu-Yau, additional, Chen, Shinn-Cherng, additional, Huang, Jee-Fu, additional, Hsieh, Ping-Hsin, additional, Chuang, Wan-Long, additional, Lee, Jin-Ching, additional, Yu, Ming-Lung, additional, and Dai, Chia-Yen, additional

Published
2019
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43. Elevated serum ferritin level associated with hepatic steatosis and fibrosis in hepatitis C virus–infected patients

Author

Batsaikhan, Batbold, primary, Gantumur, Gantsetseg, additional, Huang, Ching-I, additional, Yeh, Ming-Lun, additional, Huang, Chung-Feng, additional, Lin, Zu-Yau, additional, Chen, Shinn-Cherng, additional, Huang, Jee-Fu, additional, Yu, Ming-Lung, additional, Chuang, Wan-Long, additional, Lee, Jin-Ching, additional, and Dai, Chia-Yen, additional

Published
2019
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45. High versus standard doses interferon-alpha in the treatment of naïve chronic hepatitis C patients in Taiwan: a 10-year cohort study

Author

Tsai Jung-Fa, Wang Liang-Yen, Hsieh Ming-Yuh, Lin Zu-Yau, Hsieh Ming-Yen, Lee Li-Po, Chen Shinn-Cherng, Dai Chia-Yen, Yu Ming-Lung, Chang Wen-Yu, and Chuang Wan-Long

Subjects
Infectious and parasitic diseases, RC109-216
Abstract

Abstract Background Interferon-alpha monotherapy is effective in less than one-third patients with chronic hepatitis C. The dose-effect, tolerability and durability of interferon-alpha treatment and its long-term effect on the prevention of cirrhosis and hepatocellular carcinoma in naïve Taiwanese patients with chronic hepatitis C have not been well investigated. We conducted the present cohort study treated with high and standard interferon-alpha to illustrate the issues. Methods We performed a long-term virologic and histological follow-up of 214 chronic hepatitis C patients treated with interferon-alpha, 3 million units (3-MU, n = 80) or 6-MU (n = 134) thrice weekly for 24 weeks, in Taiwan between 1992 and 2001. Results There was no difference in the incidence of discontinuation between 3-MU and 6-MU groups (4/80, 5.0% versus 10/134. 7.5%). The 6-MU group had similar incidence of adverse events with the 3-MU group, except that 6-MU group had significantly higher incidence of psychological manifestations, mainly presented as irritability. The rates of sustained virological response (SVR) were significantly higher in 6-MU regimen (37.1%) than in 3-MU regimen (23.7%, p < 0.05) in per protocol analysis. Based on multivariate analysis, baseline viral load was strongly associated with SVR, followed by hepatitis C virus genotype, interferon-alpha regimen, and liver fibrosis. A histological improvement in necroinflammatory activity, but not in fibrosis was observed in the follow-up biopsy performed 0.5–5.5 years (mean: 1.9 years, n = 51) after end-of-treatment. Among patients without SVR, there was more activity improvement in 6-MU group. The durability of SVR was 100% (18/18) and 97.8% (45/46) for 3-MU and 6-MU group, respectively, in a mean follow-up period of 6.81 years (5.25–9.18 years). For 163 baseline non-cirrhotic patients, 9 of 84 (10.7%) non-responders and 3 of 79 (3.8%) sustained responders progressed to cirrhosis during a mean follow-up period of 5.52 and 5.74 years, respectively (p = 0.067, Kaplan-Meier survival analysis, log-rank test). For all 200 patients, hepatocellular carcinoma was detected in 12 of 113 (10.6%) non-responders and one of 87 (1.1%) sustained responders during a mean follow-up period of 5.67 and 5.73 years, respectively (p < 0.01, Kaplan-Meier survival analysis, log-rank test). Conclusion We confirm the dose effect of interferon-alpha in chronic hepatitis C. Six-MU regimen had better efficacy than 3-MU regimen in virologic and histological responses. Both regimens had good tolerability and durability in Taiwan. Sustained response could reduce the incidence of cirrhotic change and hepatocarcinogenesis.

Published
2005
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46. Paritaprevir/ritonavir/ombitasvir plus dasabuvir with ribavirin for treatment of recurrent chronic hepatitis C genotype 1 infection after liver transplantation: Real-world experience

Author

Yu, Ming-Lung, primary, Chen, Yao-Li, additional, Huang, Chung-Feng, additional, Lin, Kuo-Hua, additional, Yeh, Ming-Lun, additional, Huang, Ching-I., additional, Hsieh, Meng-Hsuan, additional, Lin, Zu-Yau, additional, Chen, Shinn-Cherng, additional, Huang, Jee-Fu, additional, Dai, Chia-Yen, additional, and Chuang, Wan-Long, additional

Published
2018
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47. Management consensus guideline for hepatocellular carcinoma: 2016 updated by the Taiwan Liver Cancer Association and the Gastroenterological Society of Taiwan

Author

Lu, Sheng-Nan, primary, Wang, Jing-Houng, additional, Su, Chien-Wei, additional, Wang, Tsang-En, additional, Dai, Chia-Yen, additional, Chen, Chien-Hung, additional, Chen, Ran-Chou, additional, Yang, Sien-Sing, additional, Hung, Chien-Fu, additional, Huang, Shiu-Feng, additional, Liao, Li-Ying, additional, Lu, Sheng-Nan, additional, Huo, The-Ia, additional, Wu, Cheng-Chung, additional, Lee, Po-Huang, additional, Ting, Chin-Tsung, additional, Lee, Wei-Chen, additional, Chau, Gar-Yang, additional, Wang, Chih-Chi, additional, Lee, King-The, additional, Huang, Yi-Hsiang, additional, Ho, Ming-Chih, additional, Lin, Shi-Ming, additional, Huang, Guan-Tarn, additional, Chen, Kuan-Yang, additional, Lin, Xi-Zhang, additional, Hwang, Jen-I., additional, Chiou, Yi-You, additional, Wang, Chung-Kwe, additional, Hu, Jui-Ting, additional, Chen, Shinn-Cherng, additional, Liang, Po-Chin, additional, Lee, Rheun-Chuan, additional, Wu, Ding-Kwo, additional, Lin, Cheng-Yao, additional, Lin, Chen-Chun, additional, Cheng, Ann-Lii, additional, Hsu, Chiun, additional, Chao, Yee, additional, Chen, Li-Tzong, additional, Wang, Po-Ming, additional, Hong, Ji-Hong, additional, Hsu, Hsuan-Chih, additional, Chen, Shang-Wen, additional, Leung, Stephen Wan, additional, Cheng, Jason Chia-Hsien, additional, Wu, Jaw-Ching, additional, Wu, Chun-Ying, additional, Hsu, Yao-Chun, additional, Hsu, Chao-Wei, additional, Ni, Yen-Hsuan, additional, and Lin, Chih-Lin, additional

Published
2018
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48. The effect of antiviral therapy on serum lipid profiles in chronic hepatitis C

Author

Batsaikhan, Batbold, primary, Huang, Ching-I, additional, Yeh, Ming-Lun, additional, Huang, Chung-Feng, additional, Hou, Nei-Jen, additional, Lin, Zu-Yau, additional, Chen, Shinn-Cherng, additional, Huang, Jee-Fu, additional, Yu, Ming-Lung, additional, Chuang, Wan-Long, additional, Lee, Jin-Ching, additional, and Dai, Chia-Yen, additional

Published
2018
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49. Post-treatment alpha fetoprotein and platelets predict hepatocellular carcinoma development in dual-infected hepatitis B and C patients after eradication of hepatitis C

Author

Yeh, Ming-Lun, primary, Huang, Ching-I, additional, Huang, Chung-Feng, additional, Hsieh, Meng-Hsuan, additional, Hsieh, Ming-Yen, additional, Lin, Zu-Yau, additional, Chen, Shinn-Cherng, additional, Huang, Jee-Fu, additional, Kuo, Po-Lin, additional, Kuo, Hsing-Tao, additional, Dai, Chia-Yen, additional, Yu, Ming-Lung, additional, and Chuang, Wan-Long, additional

Published
2018
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50. Identification of treatment-experienced hepatitis C patients with poor cost-effectiveness of pegylated interferon plus ribavirin from a real-world cohort

Author

Liu, Ta-Wei, primary, Tsai, Pei-Chien, additional, Huang, Ching-I, additional, Tsai, Yi-Shan, additional, Wang, Shu-Chi, additional, Ko, Yu-Min, additional, Lin, Ching-Chih, additional, Chen, Kuan-Yu, additional, Liang, Po-Cheng, additional, Lin, Yi-Hung, additional, Hsieh, Ming-Yen, additional, Hou, Nai-Jen, additional, Huang, Chung-Feng, additional, Yeh, Ming-Lun, additional, Lin, Zu-Yau, additional, Chen, Shinn-Cherng, additional, Dai, Chia-Yen, additional, Chuang, Wan-Long, additional, Huang, Jee-Fu, additional, and Yu, Ming-Lung, additional

Published
2018
Full Text
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