Search

Your search keyword '"Chen, Li-Jia"' showing total 374 results
Start Over Author "Chen, Li-Jia" Search Limiters Full Text
374 results on '"Chen, Li-Jia"'

1. Integrated image-based deep learning and language models for primary diabetes care

Author

Li, Jiajia, Guan, Zhouyu, Wang, Jing, Cheung, Carol Y., Zheng, Yingfeng, Lim, Lee-Ling, Lim, Cynthia Ciwei, Ruamviboonsuk, Paisan, Raman, Rajiv, Corsino, Leonor, Echouffo-Tcheugui, Justin B., Luk, Andrea O. Y., Chen, Li Jia, Sun, Xiaodong, Hamzah, Haslina, Wu, Qiang, Wang, Xiangning, Liu, Ruhan, Wang, Ya Xing, Chen, Tingli, Zhang, Xiao, Yang, Xiaolong, Yin, Jun, Wan, Jing, Du, Wei, Quek, Ten Cheer, Goh, Jocelyn Hui Lin, Yang, Dawei, Hu, Xiaoyan, Nguyen, Truong X., Szeto, Simon K. H., Chotcomwongse, Peranut, Malek, Rachid, Normatova, Nargiza, Ibragimova, Nilufar, Srinivasan, Ramyaa, Zhong, Pingting, Huang, Wenyong, Deng, Chenxin, Ruan, Lei, Zhang, Cuntai, Zhang, Chenxi, Zhou, Yan, Wu, Chan, Dai, Rongping, Koh, Sky Wei Chee, Abdullah, Adina, Hee, Nicholas Ken Yoong, Tan, Hong Chang, Liew, Zhong Hong, Tien, Carolyn Shan-Yeu, Kao, Shih Ling, Lim, Amanda Yuan Ling, Mok, Shao Feng, Sun, Lina, Gu, Jing, Wu, Liang, Li, Tingyao, Cheng, Di, Wang, Zheyuan, Qin, Yiming, Dai, Ling, Meng, Ziyao, Shu, Jia, Lu, Yuwei, Jiang, Nan, Hu, Tingting, Huang, Shan, Huang, Gengyou, Yu, Shujie, Liu, Dan, Ma, Weizhi, Guo, Minyi, Guan, Xinping, Yang, Xiaokang, Bascaran, Covadonga, Cleland, Charles R., Bao, Yuqian, Ekinci, Elif I., Jenkins, Alicia, Chan, Juliana C. N., Bee, Yong Mong, Sivaprasad, Sobha, Shaw, Jonathan E., Simó, Rafael, Keane, Pearse A., Cheng, Ching-Yu, Tan, Gavin Siew Wei, Jia, Weiping, Tham, Yih-Chung, Li, Huating, Sheng, Bin, and Wong, Tien Yin

Published
2024
Full Text
View/download PDF

5. Practice Patterns and Challenges in Managing Inherited Retinal Diseases Across Asia-Pacific: A Survey from the APIED Network

Author

Wong, Wendy M., Tham, Yih Chung, Ayton, Lauren N., Britten-Jones, Alexis Ceecee, Edwards, Thomas L., Grigg, John, Simunovic, Matthew P., Chen, Fred K., Jin, Zi-Bing, Shen, Ren-Juan, Sui, Ruifang, Yang, Liping, Zhao, Chen, Chen, Haoyu, Li, Shiying, Ding, Xiaoyan, Bhende, Muna, Raman, Rajiv, Sen, Parveen, Poornachandra, B., Chia, Valen, Manurung, Florence, Sasongko, Muhammad Bayu, Ikeda, Hanako, Fujinami, Kaoru, Woo, Se Joon, Kim, Sang Jin, Bastion, Mae-Lynn Catherine, Kamalden, Ain Tengku, Lott, Penny P., Fong, Kenneth, Shunmugam, Manoharan, Lim, Amelia, Thapa, Raba, Ibañez, B.Manuel Benjamin, Koh, Adrian, Holder, Graham E., Su, Xinyi, Chan, Choi Mun, Fenner, Beau J., Laude, Augustinus, Ngo, Wei Kiong, Chen, Ta-Ching, Wang, Nan-Kai, Kang, Eugene Yu-Chuan, Surawatsatien, Nuntachai, Pisuchpen, Phattrawan, Sujirakul, Tharikarn, Wongchaisuwat, Nida, Apivatthakakul, Atitaya, Kumaramanickavel, Govindasamy, Leroy, Bart, Michaelides, Michel, Pontikos, Nikolas, Cheng, Ching-Yu, Pang, Chi Pui, Chen, Li Jia, and Chan, Hwei Wuen

Published
2024
Full Text
View/download PDF

9. Rationale and protocol paper for the Asia Pacific Network for inherited eye diseases

Author

Wong, Wendy M., Tham, Yih Chung, Simunovic, Matthew P., Chen, Fred Kuanfu, Luu, Chi D., Chen, Haoyu, Jin, Zi-Bing, Shen, Ren-Juan, Li, Shiying, Sui, Ruifang, Zhao, Chen, Yang, Liping, Bhende, Muna, Raman, Rajiv, Sen, Parveen, Ghosh, Arkasubhra, Poornachandra, B., Sasongko, Muhammad Bayu, Arianti, Alia, Chia, Valen, Mangunsong, Cosmos O., Manurung, Florence, Fujinami, Kaoru, Ikeda, Hanako, Woo, Se Joon, Kim, Sang Jin, Mohd Khialdin, Safinaz, Othman, Othmaliza, Bastion, Mae-Lynn Catherine, Kamalden, Ain Tengku, Lott, Pooi Wah Penny, Fong, Kenneth, Shunmugam, Manoharan, Lim, Amelia, Thapa, Raba, Pradhan, Eli, Rajkarnikar, Sthapit Purnima, Adhikari, Srijana, Ibañez, B.Manuel Benjamin IV, Koh, Adrian, Chan, Choi Mun M., Fenner, Beau J., Tan, Tien-En, Laude, Augustinus, Ngo, Wei Kiong, Holder, Graham E., Su, Xinyi, Chen, Ta-Ching, Wang, Nan-Kai, Kang, Eugene Yu-Chuan, Huang, Chu-Hsuan, Surawatsatien, Nuntachai, Pisuchpen, Phattrawan, Sujirakul, Tharikarn, Kumaramanickavel, Govindasamy, Singh, Mandeep, Leroy, Bart, Michaelides, Michel, Cheng, Ching-Yu, Chen, Li Jia, and Chan, Hwei Wuen

Published
2024
Full Text
View/download PDF

14. Contribution of common and rare variants to Asian neovascular age-related macular degeneration subtypes

Author

Fan, Qiao, Li, Hengtong, Wang, Xiaomeng, Tham, Yih-Chung, Teo, Kelvin Yi Chong, Yasuda, Masayuki, Lim, Weng Khong, Kwan, Yuet Ping, Teo, Jing Xian, Chen, Ching-Jou, Chen, Li Jia, Ahn, Jeeyun, Davila, Sonia, Miyake, Masahiro, Tan, Patrick, Park, Kyu Hyung, Pang, Chi Pui, Khor, Chiea Chuan, Wong, Tien Yin, Yanagi, Yasuo, Cheung, Chui Ming Gemmy, and Cheng, Ching-Yu

Published
2023
Full Text
View/download PDF

15. Genome-wide meta-analysis identifies 127 open-angle glaucoma loci with consistent effect across ancestries.

Author

Gharahkhani, Puya, Jorgenson, Eric, Hysi, Pirro, Khawaja, Anthony P, Pendergrass, Sarah, Han, Xikun, Ong, Jue Sheng, Hewitt, Alex W, Segrè, Ayellet V, Rouhana, John M, Hamel, Andrew R, Igo, Robert P, Choquet, Helene, Qassim, Ayub, Josyula, Navya S, Cooke Bailey, Jessica N, Bonnemaijer, Pieter WM, Iglesias, Adriana, Siggs, Owen M, Young, Terri L, Vitart, Veronique, Thiadens, Alberta AHJ, Karjalainen, Juha, Uebe, Steffen, Melles, Ronald B, Nair, K Saidas, Luben, Robert, Simcoe, Mark, Amersinghe, Nishani, Cree, Angela J, Hohn, Rene, Poplawski, Alicia, Chen, Li Jia, Rong, Shi-Song, Aung, Tin, Vithana, Eranga Nishanthie, NEIGHBORHOOD consortium, ANZRAG consortium, Biobank Japan project, FinnGen study, UK Biobank Eye and Vision Consortium, GIGA study group, 23 and Me Research Team, Tamiya, Gen, Shiga, Yukihiro, Yamamoto, Masayuki, Nakazawa, Toru, Currant, Hannah, Birney, Ewan, Wang, Xin, Auton, Adam, Lupton, Michelle K, Martin, Nicholas G, Ashaye, Adeyinka, Olawoye, Olusola, Williams, Susan E, Akafo, Stephen, Ramsay, Michele, Hashimoto, Kazuki, Kamatani, Yoichiro, Akiyama, Masato, Momozawa, Yukihide, Foster, Paul J, Khaw, Peng T, Morgan, James E, Strouthidis, Nicholas G, Kraft, Peter, Kang, Jae H, Pang, Chi Pui, Pasutto, Francesca, Mitchell, Paul, Lotery, Andrew J, Palotie, Aarno, van Duijn, Cornelia, Haines, Jonathan L, Hammond, Chris, Pasquale, Louis R, Klaver, Caroline CW, Hauser, Michael, Khor, Chiea Chuen, Mackey, David A, Kubo, Michiaki, Cheng, Ching-Yu, Craig, Jamie E, MacGregor, Stuart, and Wiggs, Janey L

Subjects
NEIGHBORHOOD consortium, ANZRAG consortium, Biobank Japan project, FinnGen study, UK Biobank Eye and Vision Consortium, GIGA study group, and Me Research Team, Humans, Glaucoma, Open-Angle, Genetic Predisposition to Disease, Genotype, Polymorphism, Single Nucleotide, Asian Continental Ancestry Group, European Continental Ancestry Group, Genome-Wide Association Study, Genetic Loci, Glaucoma, Open-Angle, Polymorphism, Single Nucleotide
Abstract

Primary open-angle glaucoma (POAG), is a heritable common cause of blindness world-wide. To identify risk loci, we conduct a large multi-ethnic meta-analysis of genome-wide association studies on a total of 34,179 cases and 349,321 controls, identifying 44 previously unreported risk loci and confirming 83 loci that were previously known. The majority of loci have broadly consistent effects across European, Asian and African ancestries. Cross-ancestry data improve fine-mapping of causal variants for several loci. Integration of multiple lines of genetic evidence support the functional relevance of the identified POAG risk loci and highlight potential contributions of several genes to POAG pathogenesis, including SVEP1, RERE, VCAM1, ZNF638, CLIC5, SLC2A12, YAP1, MXRA5, and SMAD6. Several drug compounds targeting POAG risk genes may be potential glaucoma therapeutic candidates.

Published
2021

17. A new polygenic score for refractive error improves detection of children at risk of high myopia but not the prediction of those at risk of myopic macular degeneration

Author

Bailey-Wilson, Joan E., Baird, Paul N., Barathi, Veluchamy A., Biino, Ginevra, Burdon, Kathryn P., Campbell, Harry, Chen, Li Jia, Cheng, Ching-Yu, Chew, Emily Y., Craig, Jamie E., Deangelis, Margaret M., Delcourt, Cécile, Ding, Xiaohu, Fan, Qiao, Fossarello, Maurizio, Foster, Paul J., Gharahkhani, Puya, Guggenheim, Jeremy A., Guo, Xiaobo, Haarman, Annechien E.G., Haller, Toomas, Hammond, Christopher J., Han, Xikun, Hayward, Caroline, He, Mingguang, Hewitt, Alex W., Hoang, Quan, Hysi, Pirro G., Iglesias, Adriana I., Igo, Robert P., Iyengar, Sudha K., Jonas, Jost B., Kähönen, Mika, Kaprio, Jaakko, Khawaja, Anthony P., Klein, Barbara E., Lass, Jonathan H., Lee, Kris, Lehtimäki, Terho, Lewis, Deyana, Li, Qing, Li, Shi-Ming, Lyytikäinen, Leo-Pekka, MacGregor, Stuart, Mackey, David A., Martin, Nicholas G., Meguro, Akira, Metspalu, Andres, Middlebrooks, Candace, Miyake, Masahiro, Mizuki, Nobuhisa, Musolf, Anthony, Nickels, Stefan, Oexle, Konrad, Pang, Chi Pui, Pärssinen, Olavi, Paterson, Andrew D., Pfeiffer, Norbert, Polasek, Ozren, Rahi, Jugnoo S., Raitakari, Olli, Rudan, Igor, Sahebjada, Srujana, Saw, Seang-Mei, Simpson, Claire L., Stambolian, Dwight, Tai, E-Shyong, Tedja, Milly S., Tideman, J. Willem L., Tsujikawa, Akitaka, van Duijn, Cornelia M., Verhoeven, Virginie J.M., Vitart, Veronique, Wang, Ningli, Wang, Ya Xing, Wedenoja, Juho, Wei, Wen Bin, Williams, Cathy, Williams, Katie M., Wilson, James F., Wojciechowski, Robert, Yam, Jason C.S., Yamashiro, Kenji, Yap, Maurice K.H., Yazar, Seyhan, Yip, Shea Ping, Young, Terri L., Zhou, Xiangtian, Allen, Naomi, Aslam, Tariq, Atan, Denize, Barman, Sarah, Barrett, Jenny, Bishop, Paul, Black, Graeme, Bunce, Catey, Carare, Roxana, Chakravarthy, Usha, Chan, Michelle, Chua, Sharon, Cipriani, Valentina, Day, Alexander, Desai, Parul, Dhillon, Bal, Dick, Andrew, Doney, Alexander, Egan, Cathy, Ennis, Sarah, Foster, Paul, Fruttiger, Marcus, Gallacher, John, Garway-Heath, David, Gibson, Jane, Gore, Dan, Guggenheim, Jeremy, Hammond, Chris, Hardcastle, Alison, Harding, Simon, Hogg, Ruth, Hysi, Pirro, Keane, Pearse A., Khaw, Peng Tee, Khawaja, Anthony, Lascaratos, Gerassimos, Littlejohns, Thomas, Lotery, Andrew, Luthert, Phil, MacGillivray, Tom, Mackie, Sarah, McGuinness, Bernadette, McKay, Gareth, McKibbin, Martin, Mitry, Danny, Moore, Tony, Morgan, James, Muthy, Zaynah, O'Sullivan, Eoin, Owen, Chris, Patel, Praveen, Paterson, Euan, Peto, Tunde, Petzold, Axel, Pontikos, Nikolas, Rahi, Jugnoo, Rudnicka, Alicja, Self, Jay, Sergouniotis, Panagiotis, Sivaprasad, Sobha, Steel, David, Stratton, Irene, Strouthidis, Nicholas, Sudlow, Cathie, Tapp, Robyn, Thaung, Caroline, Thomas, Dhanes, Trucco, Emanuele, Tufail, Adnan, Vernon, Stephen, Viswanathan, Ananth, Williams, Katie, Woodside, Jayne, Yates, Max, Yip, Jennifer, Zheng, Yalin, Clark, Rosie, Lee, Samantha Sze-Yee, Du, Ran, Wang, Yining, Kneepkens, Sander C.M., Charng, Jason, Huang, Yu, Hunter, Michael L., Jiang, Chen, Tideman, J.Willem L., Melles, Ronald B., Klaver, Caroline C.W., Choquet, Hélène, and Ohno-Matsui, Kyoko

Published
2023
Full Text
View/download PDF

21. Integrating genetic regulation and single-cell expression with GWAS prioritizes causal genes and cell types for glaucoma

Author

Hamel, Andrew R., Yan, Wenjun, Rouhana, John M., Monovarfeshani, Aboozar, Jiang, Xinyi, Mehta, Puja A., Advani, Jayshree, Luo, Yuyang, Liang, Qingnan, Rajasundaram, Skanda, Shrivastava, Arushi, Duchinski, Katherine, Mantena, Sreekar, Wang, Jiali, van Zyl, Tavé, Pasquale, Louis R., Swaroop, Anand, Gharahkhani, Puya, Khawaja, Anthony P., MacGregor, Stuart, Hewitt, Alex W., Schuster, Alexander K., Viswanathan, Ananth C., Lotery, Andrew J., Cree, Angela J., Pang, Calvin P., Brandl, Caroline, Klaver, Caroline C.W., Hayward, Caroline, Khor, Chiea Chuen, Cheng, Ching Yu, Hammond, Christopher J., van Duijn, Cornelia, Mackey, David A., Stefansson, Einer, Vithana, Eranga N., Pasutto, Francesca, Jonansson, Fridbert, Thorleifsson, Gudmar, Koh, Jacyline, Wilson, James F., Craig, Jamie E., Vergroesen, Joëlle E., Fingert, John H., Jonas, Jost B., Stefánsson, Kári, Burdon, Kathryn P., Chen, Li Jia, Driessen, Sjoerd J., Ramdas, Wishal D., de Vries, VA (Victor), Hamel, Andrew R., Yan, Wenjun, Rouhana, John M., Monovarfeshani, Aboozar, Jiang, Xinyi, Mehta, Puja A., Advani, Jayshree, Luo, Yuyang, Liang, Qingnan, Rajasundaram, Skanda, Shrivastava, Arushi, Duchinski, Katherine, Mantena, Sreekar, Wang, Jiali, van Zyl, Tavé, Pasquale, Louis R., Swaroop, Anand, Gharahkhani, Puya, Khawaja, Anthony P., MacGregor, Stuart, Hewitt, Alex W., Schuster, Alexander K., Viswanathan, Ananth C., Lotery, Andrew J., Cree, Angela J., Pang, Calvin P., Brandl, Caroline, Klaver, Caroline C.W., Hayward, Caroline, Khor, Chiea Chuen, Cheng, Ching Yu, Hammond, Christopher J., van Duijn, Cornelia, Mackey, David A., Stefansson, Einer, Vithana, Eranga N., Pasutto, Francesca, Jonansson, Fridbert, Thorleifsson, Gudmar, Koh, Jacyline, Wilson, James F., Craig, Jamie E., Vergroesen, Joëlle E., Fingert, John H., Jonas, Jost B., Stefánsson, Kári, Burdon, Kathryn P., Chen, Li Jia, Driessen, Sjoerd J., Ramdas, Wishal D., and de Vries, VA (Victor)

Abstract

Primary open-angle glaucoma (POAG), characterized by retinal ganglion cell death, is a leading cause of irreversible blindness worldwide. However, its molecular and cellular causes are not well understood. Elevated intraocular pressure (IOP) is a major risk factor, but many patients have normal IOP. Colocalization and Mendelian randomization analysis of >240 POAG and IOP genome-wide association study (GWAS) loci and overlapping expression and splicing quantitative trait loci (e/sQTLs) in 49 GTEx tissues and retina prioritizes causal genes for 60% of loci. These genes are enriched in pathways implicated in extracellular matrix organization, cell adhesion, and vascular development. Analysis of single-nucleus RNA-seq of glaucoma-relevant eye tissues reveals that the POAG and IOP colocalizing genes and genome-wide associations are enriched in specific cell types in the aqueous outflow pathways, retina, optic nerve head, peripapillary sclera, and choroid. This study nominates IOP-dependent and independent regulatory mechanisms, genes, and cell types that may contribute to POAG pathogenesis.

Published
2024

22. Preoperative Intravitreal Conbercept Injection Reduced Both Angiogenic and Inflammatory Cytokines in Patients With Proliferative Diabetic Retinopathy.

Author

Huang, Zijing, Chen, Li Jia, Huang, Dingguo, Yi, Jingsheng, Chen, Zhiying, Lin, Peimin, Wang, Yifan, Zheng, Jianlong, Chen, Weiqi, and Campesi, Ilaria

Subjects
*VASCULAR endothelial growth factor receptors, *INTRAVITREAL injections, *INFLAMMATORY mediators, *AQUEOUS humor, *VISION
Abstract

Aims: To investigate the impact of intravitreal injection of conbercept, a recombinant fusion protein with decoy receptors for the vascular endothelial growth factor (VEGF) family, on intraocular concentrations of angiogenic and inflammatory mediators in patients with proliferative diabetic retinopathy (PDR), analyzed its potential impact on surgical outcomes. Methods: Forty eyes from 40 patients with PDR were included in this prospective study. Patients received intravitreal injection of conbercept followed by vitrectomy or phacovitrectomy in 1 week. Aqueous humor samples were collected before and 1 week after the conbercept injection. The concentrations of angiogenic and inflammatory cytokines and chemokines were measured by flow cytometry. Follow‐up clinical data were collected and analyzed. Results: Intravitreal conbercept injection significantly decreased aqueous concentrations of VEGF (325.5 (baseline) versus 22.3 pg/mL (postinjection), p < 0.0001), PlGF (39.5 versus 24.5 pg/mL, p < 0.0001), and PDGF‐A (54.1 versus 47.0 pg/mL, p = 0.0016), while no impact on bFGF levels. For inflammatory mediators, the concentration of TNF‐α (0.79 versus 0.45 pg/mL, p = 0.0004) and IL‐8 (180.6 versus 86 pg/mL, p < 0.0001) were decreased, while IL‐6 (184.1 versus 333.7 pg/mL, p = 0.0003) and IL‐10 (1.1 versus 1.5 pg/mL, p = 0.0032) were increased. No significant changes in IFN‐γ or MCP‐1 were detected. Three months after surgery, the mean best‐corrected visual acuity improved from a baseline of 1.8 ± 0.1 logMAR to 0.7 ± 0.1 logMAR (p < 0.0001), with 36 eyes (90%) achieving an improvement of visual function. Conclusions: Intravitreal conbercept injection presents dual effects of antiangiogenesis and anti‐inflammation and can be served as an adjuvant treatment to vitrectomy for PDR patients. [ABSTRACT FROM AUTHOR]

Published
2024
Full Text
View/download PDF

23. Projecting the Impacts of Climate Change, Soil, and Landscape on the Geographic Distribution of Ma Bamboo (Dendrocalamus latiflorus Munro) in China.

Author

Chen, Li-Jia, Xie, Yan-Qiu, He, Tian-You, Chen, Ling-Yan, Rong, Jun-Dong, Chen, Li-Guang, and Zheng, Yu-Shan

Subjects
CLAY soils, HABITATS, GERMPLASM conservation, SOIL conservation, SPECIES distribution
Abstract

Ma bamboo (Dendrocalamus latiflorus Munro) is a fast-growing woody grass that offers significant economic benefits, including materials for construction, furniture, biofuel, food, and handicrafts. It also provides ecological benefits like soil conservation, wildlife habitats, and carbon sequestration. However, its species distribution patterns are influenced by various factors, including climate (mainly temperature and precipitation), soil attributes, and landscape characteristics such as topography, land use, and vegetation. Understanding these impacts is essential for the sustainable management of D. latiflorus resources and fostering related economic activities. To address these challenges, we developed a comprehensive habitat suitability (CHS) model that integrates climate, soil, and landscape variables to simulate the distribution dynamics of D. latiflorus under different shared socio-economic pathway (SSP) scenarios. An ensemble model (EM) strategy was applied to each variable set to ensure robust predictions. The results show that the current potential distribution of D. latiflorus spans 28.95 × 104 km2, primarily located in South China and the Sichuan Basin. Its distribution is most influenced by the annual mean temperature (Bio1), the cation exchange capacity of soil clay particles in the 20–40 cm soil layer (CECc 20–40 cm), vegetation, and elevation. Under future climate scenarios, these habitats are projected to initially expand slightly and then contract, with a northward shift in latitude and migration to higher elevations. Additionally, the Sichuan Basin (Sichuan–Chongqing border) is identified as a climatically stable area suitable for germplasm development and conservation. To conclude, our findings shed light on how climate change impacts the geographic distribution of D. latiflorus, providing key theoretical foundations for its sustainable cultivation and conservation strategies. [ABSTRACT FROM AUTHOR]

Published
2024
Full Text
View/download PDF

24. Genome-wide association study identifies five new susceptibility loci for primary angle closure glaucoma

Author

Khor, Chiea Chuen, Do, Tan, Jia, Hongyan, Nakano, Masakazu, George, Ronnie, Abu-Amero, Khaled, Duvesh, Roopam, Chen, Li Jia, Li, Zheng, Nongpiur, Monisha E, Perera, Shamira A, Qiao, Chunyan, Wong, Hon-Tym, Sakai, Hiroshi, Barbosa de Melo, Mônica, Lee, Mei-Chin, Chan, Anita S, Azhany, Yaakub, Dao, Thi Lam Huong, Ikeda, Yoko, Perez-Grossmann, Rodolfo A, Zarnowski, Tomasz, Day, Alexander C, Jonas, Jost B, Tam, Pancy OS, Tran, Tuan Anh, Ayub, Humaira, Akhtar, Farah, Micheal, Shazia, Chew, Paul TK, Aljasim, Leyla A, Dada, Tanuj, Luu, Tam Thi, Awadalla, Mona S, Kitnarong, Naris, Wanichwecharungruang, Boonsong, Aung, Yee Yee, Mohamed-Noor, Jelinar, Vijayan, Saravanan, Sarangapani, Sripriya, Husain, Rahat, Jap, Aliza, Baskaran, Mani, Goh, David, Su, Daniel H, Wang, Huaizhou, Yong, Vernon K, Yip, Leonard W, Trinh, Tuyet Bach, Makornwattana, Manchima, Nguyen, Thanh Thu, Leuenberger, Edgar U, Park, Ki-Ho, Wiyogo, Widya Artini, Kumar, Rajesh S, Tello, Celso, Kurimoto, Yasuo, Thapa, Suman S, Pathanapitoon, Kessara, Salmon, John F, Sohn, Yong Ho, Fea, Antonio, Ozaki, Mineo, Lai, Jimmy SM, Tantisevi, Visanee, Khaing, Chaw Chaw, Mizoguchi, Takanori, Nakano, Satoko, Kim, Chan-Yun, Tang, Guangxian, Fan, Sujie, Wu, Renyi, Meng, Hailin, Nguyen, Thi Thuy Giang, Tran, Tien Dat, Ueno, Morio, Martinez, Jose Maria, Ramli, Norlina, Aung, Yin Mon, Reyes, Rigo Daniel, Vernon, Stephen A, Fang, Seng Kheong, Xie, Zhicheng, Chen, Xiao Yin, Foo, Jia Nee, Sim, Kar Seng, Wong, Tina T, Quek, Desmond T, Venkatesh, Rengaraj, Kavitha, Srinivasan, Krishnadas, Subbiah R, Soumittra, Nagaswamy, Shantha, Balekudaru, Lim, Boon-Ang, Ogle, Jeanne, de Vasconcellos, José PC, Costa, Vital P, Abe, Ricardo Y, de Souza, Bruno B, and Sng, Chelvin C

Subjects
Neurodegenerative, Human Genome, Eye Disease and Disorders of Vision, Aging, Genetics, Cell Line, Chromosome Mapping, Female, Gene Expression, Genetic Loci, Genetic Predisposition to Disease, Genome-Wide Association Study, Genotype, Glaucoma, Angle-Closure, Humans, Male, Biological Sciences, Medical and Health Sciences, Developmental Biology
Abstract

Primary angle closure glaucoma (PACG) is a major cause of blindness worldwide. We conducted a genome-wide association study (GWAS) followed by replication in a combined total of 10,503 PACG cases and 29,567 controls drawn from 24 countries across Asia, Australia, Europe, North America, and South America. We observed significant evidence of disease association at five new genetic loci upon meta-analysis of all patient collections. These loci are at EPDR1 rs3816415 (odds ratio (OR) = 1.24, P = 5.94 × 10(-15)), CHAT rs1258267 (OR = 1.22, P = 2.85 × 10(-16)), GLIS3 rs736893 (OR = 1.18, P = 1.43 × 10(-14)), FERMT2 rs7494379 (OR = 1.14, P = 3.43 × 10(-11)), and DPM2-FAM102A rs3739821 (OR = 1.15, P = 8.32 × 10(-12)). We also confirmed significant association at three previously described loci (P < 5 × 10(-8) for each sentinel SNP at PLEKHA7, COL11A1, and PCMTD1-ST18), providing new insights into the biology of PACG.

Published
2016

27. Cost-Effectiveness Analysis of Myopia Progression Interventions in Children

Author

Agyekum, Sylvia, primary, Chan, Poemen P., additional, Adjei, Prince E., additional, Zhang, Yuzhou, additional, Huo, Zhaohua, additional, Yip, Benjamin H. K., additional, Ip, Patrick, additional, Wong, Ian C. K., additional, Zhang, Wei, additional, Tham, Clement C., additional, Chen, Li Jia, additional, Zhang, Xiu Juan, additional, Pang, Chi Pui, additional, and Yam, Jason C., additional

Published
2023
Full Text
View/download PDF

32. Analysis of Secondhand Smoke Exposure and Myopia Among Children Aged 6 to 8 Years in Hong Kong

Author

Zhang, Youjuan, primary, Zhang, Xiu Juan, additional, Yuan, Nan, additional, Zhang, Yuzhou, additional, Wang, Yu Meng, additional, Tang, Fangyao, additional, Ng, Mandy P., additional, Wong, Ian C. K., additional, Ip, Patrick, additional, Kam, Ka Wai, additional, Young, Alvin L., additional, Chen, Li Jia, additional, Tham, Clement C., additional, Pang, Chi Pui, additional, and Yam, Jason C., additional

Published
2023
Full Text
View/download PDF

33. Multi-Polymorphism Analysis Reveals Joint Effects in Males With Chronic Central Serous Chorioretinopathy

Author

Chen, Zhen Ji, primary, Ng, Danny S. C., additional, Cen, Ling-Ping, additional, Ng, Tsz Kin, additional, Ho, Mary, additional, Brelen, Marten E., additional, Li, Tai-Ping, additional, Lu, Shi Yao, additional, Tam, Pancy O. S., additional, Young, Alvin L., additional, Chen, Weiqi, additional, Yam, Jason C., additional, Chen, Haoyu, additional, Tham, Clement C., additional, Pang, Chi Pui, additional, and Chen, Li Jia, additional

Published
2023
Full Text
View/download PDF

34. Prevalence and Characteristics of Peripapillary Gamma Zone in Children With Different Refractive Status: The Hong Kong Children Eye Study

Author

Zhang, Xiu Juan, primary, Chau, Duncan Ka Shun, additional, Wang, Yu Meng, additional, Cheung, Cynthia Sze Hang, additional, Chan, Hei-Nga, additional, Shi, Jian, additional, Nip, Ka Ming, additional, Tang, Shumin, additional, Chan, Ryan C. F., additional, Lau, Alistair, additional, Kei, Sit Hui, additional, Kam, Ka Wai, additional, Young, Alvin L., additional, Chen, Li Jia, additional, Tham, Clement C., additional, Ohno-Matsui, Kyoko, additional, Pang, Chi Pui, additional, and Yam, Jason C., additional

Published
2023
Full Text
View/download PDF

35. A new polygenic score for refractive error improves detection of children at risk of high myopia but not the prediction of those at risk of myopic macular degeneration

Author

Clark, Rosie, primary, Lee, Samantha Sze-Yee, additional, Du, Ran, additional, Wang, Yining, additional, Kneepkens, Sander C.M., additional, Charng, Jason, additional, Huang, Yu, additional, Hunter, Michael L., additional, Jiang, Chen, additional, Tideman, J.Willem L., additional, Melles, Ronald B., additional, Klaver, Caroline C.W., additional, Mackey, David A., additional, Williams, Cathy, additional, Choquet, Hélène, additional, Ohno-Matsui, Kyoko, additional, Guggenheim, Jeremy A., additional, Bailey-Wilson, Joan E., additional, Baird, Paul N., additional, Barathi, Veluchamy A., additional, Biino, Ginevra, additional, Burdon, Kathryn P., additional, Campbell, Harry, additional, Chen, Li Jia, additional, Cheng, Ching-Yu, additional, Chew, Emily Y., additional, Craig, Jamie E., additional, Deangelis, Margaret M., additional, Delcourt, Cécile, additional, Ding, Xiaohu, additional, Fan, Qiao, additional, Fossarello, Maurizio, additional, Foster, Paul J., additional, Gharahkhani, Puya, additional, Guo, Xiaobo, additional, Haarman, Annechien E.G., additional, Haller, Toomas, additional, Hammond, Christopher J., additional, Han, Xikun, additional, Hayward, Caroline, additional, He, Mingguang, additional, Hewitt, Alex W., additional, Hoang, Quan, additional, Hysi, Pirro G., additional, Iglesias, Adriana I., additional, Igo, Robert P., additional, Iyengar, Sudha K., additional, Jonas, Jost B., additional, Kähönen, Mika, additional, Kaprio, Jaakko, additional, Khawaja, Anthony P., additional, Klein, Barbara E., additional, Lass, Jonathan H., additional, Lee, Kris, additional, Lehtimäki, Terho, additional, Lewis, Deyana, additional, Li, Qing, additional, Li, Shi-Ming, additional, Lyytikäinen, Leo-Pekka, additional, MacGregor, Stuart, additional, Martin, Nicholas G., additional, Meguro, Akira, additional, Metspalu, Andres, additional, Middlebrooks, Candace, additional, Miyake, Masahiro, additional, Mizuki, Nobuhisa, additional, Musolf, Anthony, additional, Nickels, Stefan, additional, Oexle, Konrad, additional, Pang, Chi Pui, additional, Pärssinen, Olavi, additional, Paterson, Andrew D., additional, Pfeiffer, Norbert, additional, Polasek, Ozren, additional, Rahi, Jugnoo S., additional, Raitakari, Olli, additional, Rudan, Igor, additional, Sahebjada, Srujana, additional, Saw, Seang-Mei, additional, Simpson, Claire L., additional, Stambolian, Dwight, additional, Tai, E-Shyong, additional, Tedja, Milly S., additional, Tideman, J. Willem L., additional, Tsujikawa, Akitaka, additional, van Duijn, Cornelia M., additional, Verhoeven, Virginie J.M., additional, Vitart, Veronique, additional, Wang, Ningli, additional, Wang, Ya Xing, additional, Wedenoja, Juho, additional, Wei, Wen Bin, additional, Williams, Katie M., additional, Wilson, James F., additional, Wojciechowski, Robert, additional, Yam, Jason C.S., additional, Yamashiro, Kenji, additional, Yap, Maurice K.H., additional, Yazar, Seyhan, additional, Yip, Shea Ping, additional, Young, Terri L., additional, Zhou, Xiangtian, additional, Allen, Naomi, additional, Aslam, Tariq, additional, Atan, Denize, additional, Barman, Sarah, additional, Barrett, Jenny, additional, Bishop, Paul, additional, Black, Graeme, additional, Bunce, Catey, additional, Carare, Roxana, additional, Chakravarthy, Usha, additional, Chan, Michelle, additional, Chua, Sharon, additional, Cipriani, Valentina, additional, Day, Alexander, additional, Desai, Parul, additional, Dhillon, Bal, additional, Dick, Andrew, additional, Doney, Alexander, additional, Egan, Cathy, additional, Ennis, Sarah, additional, Foster, Paul, additional, Fruttiger, Marcus, additional, Gallacher, John, additional, Garway-Heath, David, additional, Gibson, Jane, additional, Gore, Dan, additional, Guggenheim, Jeremy, additional, Hammond, Chris, additional, Hardcastle, Alison, additional, Harding, Simon, additional, Hogg, Ruth, additional, Hysi, Pirro, additional, Keane, Pearse A., additional, Khaw, Peng Tee, additional, Khawaja, Anthony, additional, Lascaratos, Gerassimos, additional, Littlejohns, Thomas, additional, Lotery, Andrew, additional, Luthert, Phil, additional, MacGillivray, Tom, additional, Mackie, Sarah, additional, McGuinness, Bernadette, additional, McKay, Gareth, additional, McKibbin, Martin, additional, Mitry, Danny, additional, Moore, Tony, additional, Morgan, James, additional, Muthy, Zaynah, additional, O'Sullivan, Eoin, additional, Owen, Chris, additional, Patel, Praveen, additional, Paterson, Euan, additional, Peto, Tunde, additional, Petzold, Axel, additional, Pontikos, Nikolas, additional, Rahi, Jugnoo, additional, Rudnicka, Alicja, additional, Self, Jay, additional, Sergouniotis, Panagiotis, additional, Sivaprasad, Sobha, additional, Steel, David, additional, Stratton, Irene, additional, Strouthidis, Nicholas, additional, Sudlow, Cathie, additional, Tapp, Robyn, additional, Thaung, Caroline, additional, Thomas, Dhanes, additional, Trucco, Emanuele, additional, Tufail, Adnan, additional, Vernon, Stephen, additional, Viswanathan, Ananth, additional, Williams, Katie, additional, Woodside, Jayne, additional, Yates, Max, additional, Yip, Jennifer, additional, and Zheng, Yalin, additional

Published
2023
Full Text
View/download PDF

36. Rare variant analyses across multiethnic cohorts identify novel genes for refractive error

Author

Musolf, Anthony M., Haarman, Annechien E.G., Luben, Robert N., Ong, Jue Sheng, Patasova, Karina, Trapero, Rolando Hernandez, Marsh, Joseph, Jain, Ishika, Jain, Riya, Wang, Paul Zhiping, Lewis, Deyana D., Tedja, Milly S., Iglesias, Adriana I., Li, Hengtong, Cowan, Cameron S., Baird, Paul Nigel, Veluchamy, Amutha Barathi, Burdon, Kathryn P., Campbell, Harry, Chen, Li Jia, Cheng, Ching Yu, Chew, Emily Y., Craig, Jamie E., Cumberland, Phillippa M., Deangelis, Margaret M., Delcourt, Cécile, Ding, Xiaohu, Evans, David M., Fan, Qiao, Fossarello, Maurizio, Foster, Paul J., Gharahkhani, Puya, Guggenheim, Jeremy A., Guo, Xiaobo, Han, Xikun, He, Mingguang, Hewitt, Alex W., Hoang, Quan V., Iyengar, Sudha K., Jonas, Jost B., Kähönen, Mika, Kaprio, Jaakko, Klein, Barbara E., Lass, Jonathan H., Wang, Ya Xing, van Duijn, Cornelia M., Verhoeven, Virginie J.M., Klaver, Caroline C.W., Bailey-Wilson, Joan E., Musolf, Anthony M., Haarman, Annechien E.G., Luben, Robert N., Ong, Jue Sheng, Patasova, Karina, Trapero, Rolando Hernandez, Marsh, Joseph, Jain, Ishika, Jain, Riya, Wang, Paul Zhiping, Lewis, Deyana D., Tedja, Milly S., Iglesias, Adriana I., Li, Hengtong, Cowan, Cameron S., Baird, Paul Nigel, Veluchamy, Amutha Barathi, Burdon, Kathryn P., Campbell, Harry, Chen, Li Jia, Cheng, Ching Yu, Chew, Emily Y., Craig, Jamie E., Cumberland, Phillippa M., Deangelis, Margaret M., Delcourt, Cécile, Ding, Xiaohu, Evans, David M., Fan, Qiao, Fossarello, Maurizio, Foster, Paul J., Gharahkhani, Puya, Guggenheim, Jeremy A., Guo, Xiaobo, Han, Xikun, He, Mingguang, Hewitt, Alex W., Hoang, Quan V., Iyengar, Sudha K., Jonas, Jost B., Kähönen, Mika, Kaprio, Jaakko, Klein, Barbara E., Lass, Jonathan H., Wang, Ya Xing, van Duijn, Cornelia M., Verhoeven, Virginie J.M., Klaver, Caroline C.W., and Bailey-Wilson, Joan E.

Abstract

Refractive error, measured here as mean spherical equivalent (SER), is a complex eye condition caused by both genetic and environmental factors. Individuals with strong positive or negative values of SER require spectacles or other approaches for vision correction. Common genetic risk factors have been identified by genome-wide association studies (GWAS), but a great part of the refractive error heritability is still missing. Some of this heritability may be explained by rare variants (minor allele frequency [MAF] ≤ 0.01.). We performed multiple gene-based association tests of mean Spherical Equivalent with rare variants in exome array data from the Consortium for Refractive Error and Myopia (CREAM). The dataset consisted of over 27,000 total subjects from five cohorts of Indo-European and Eastern Asian ethnicity. We identified 129 unique genes associated with refractive error, many of which were replicated in multiple cohorts. Our best novel candidates included the retina expressed PDCD6IP, the circadian rhythm gene PER3, and P4HTM, which affects eye morphology. Future work will include functional studies and validation. Identification of genes contributing to refractive error and future understanding of their function may lead to better treatment and prevention of refractive errors, which themselves are important risk factors for various blinding conditions.

Published
2023

42. Cost-effectiveness analysis of myopia management: A systematic review

Author

Agyekum, Sylvia, primary, Chan, Poemen P., additional, Zhang, Yuzhou, additional, Huo, Zhaohua, additional, Yip, Benjamin H. K., additional, Ip, Patrick, additional, Tham, Clement C., additional, Chen, Li Jia, additional, Zhang, Xiu Juan, additional, Pang, Chi Pui, additional, and Yam, Jason C., additional

Published
2023
Full Text
View/download PDF

45. Effect of Myopic Undercorrection on Habitual Reading Distance in Schoolchildren: The Hong Kong Children Eye Study

Author

Tang, Shu Min, primary, Zhang, Xiu Juan, additional, Wang, Yu Meng, additional, Zhang, Yuzhou, additional, Wong, Lok Man, additional, Chan, Hei-Nga, additional, Zhang, Bi Ning, additional, Chu, Wai Kit, additional, Kam, Ka Wai, additional, Young, Alvin L., additional, Tham, Clement C., additional, Chen, Li Jia, additional, French, Amanda N., additional, Rose, Kathryn A., additional, Pang, Chi Pui, additional, and Yam, Jason C., additional

Published
2022
Full Text
View/download PDF

46. Association of Maternal and Paternal Astigmatism With Child Astigmatism in the Hong Kong Children Eye Study

Author

Kam, Ka Wai, primary, Chee, Arnold S. H., additional, Zhang, Yuzhou, additional, Tang, Rex C. Y., additional, Chan, Jason T. C., additional, Zhang, Xiu Juan, additional, Wang, Yu Meng, additional, Chan, Ryan C. F., additional, Chu, Wai Kit, additional, Ip, Patrick, additional, Young, Alvin L., additional, Tham, Clement C., additional, Pang, Chi Pui, additional, Chen, Li Jia, additional, and Yam, Jason C., additional

Published
2022
Full Text
View/download PDF

48. HDL-cholesterol levels and risk of age-related macular degeneration: a multiethnic genetic study using Mendelian randomization

Author

Fan, Qiao, Maranville, Joseph C, Fritsche, Lars, Sim, Xueling, Cheung, Chui Ming Gemmy, Chen, Li Jia, Gorski, Mathias, Yamashiro, Kenji, Ahn, Jeeyun, Laude, Augustinus, Dorajoo, Rajkumar, Lim, Tock Han, Teo, Yik-Ying, Blaustein, Robert O, Yoshimura, Nagahisa, Park, Kyu-Hyung, Pang, Chi Pui, Tai, Shyong E, Khor, Chiea Chuen, Wong, Tien Yin, Runz, Heiko, and Cheng, Ching-Yu

Published
2017
Full Text
View/download PDF

49. Differential compensatory role of internal astigmatism in school children and adults: The Hong Kong Children Eye Study

Author

Kam, Ka Wai, primary, Chee, Arnold Shau Hei, additional, Tang, Rex Chin Yung, additional, Zhang, Yuzhou, additional, Zhang, Xiu Juan, additional, Wang, Yu Meng, additional, Li, Sophia Ling, additional, Chen, Li Jia, additional, Young, Alvin L., additional, Tham, Clement C., additional, Pang, Chi Pui, additional, and Yam, Jason C., additional

Published
2022
Full Text
View/download PDF

50. Vitamin D and Ocular Diseases: A Systematic Review

Author

Chan, Hei-Nga, primary, Zhang, Xiu-Juan, additional, Ling, Xiang-Tian, additional, Bui, Christine Huyen-Trang, additional, Wang, Yu-Meng, additional, Ip, Patrick, additional, Chu, Wai-Kit, additional, Chen, Li-Jia, additional, Tham, Clement C., additional, Yam, Jason C., additional, and Pang, Chi-Pui, additional

Published
2022
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results