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As organizations increasingly view information as one of their most valuable assets, which supports the creation and distribution of their products and services, information security will be an integral part of the design and operation of organizational business processes. Yet, risks associated with cyber attacks are on the rise. Organizations that are subjected to attacks can suffer significant reputational damage as well as loss of information and knowledge. As a consequence, effective leadership is cited as a critical factor for ensuring corporate level attention for information security. However, there is a lack of empirical understanding as to the roles strategic leaders play in shaping and supporting the cyber security strategy. This study seeks to address this gap in the literature by focusing on how senior leaders support the cyber security strategy. The authors conducted a series of exploratory interviews with leaders in the positions of Chief Information Officer, Chief Security Information Officer, and Chief Technology Officer. The findings revealed that leaders are engaged in both transitional, where the focus is on improving governance and integration, and transformational support, which involves fostering a new cultural mindset for cyber resiliency and the development of an ecosystem approach to security thinking. Managerial relevance statement Our findings provide interesting insights for managers particularly those in the role of Chief Information Officers (CIOs), Chief Security Information Officers (CSIOs), and Chief Technology Officers (CTOs). We propose a Cyber Security Strategy Framework (CSSF) which can be used by these information/technology managers to design an effective organizational strategy to develop cyber resilience in their organization. Our framework suggests that managers should focus on transitional and transformational support. The transitional support focuses on improving governance and integration whereas transformational support focuses on the emphasis of fostering a new cultural mindset for cyber resiliency and the development of an ecosystem approach to security thinking. Our findings provide good evidence showing how leaders can support more effective cyber security initiatives.

Background: Recent studies show that ultra-large immune complexes consisting of IgG and platelet factor 4 and heparin (P+H) potently activate complement and facilitate complement dependent activation of cellular FcgRIIA (PMID 34189574). In whole blood assays using KKO, a monoclonal anti-PF4/heparin antibody, or antibodies from patients with heparin induced thrombocytopenia (HIT), we showed that classical pathway (CP) inhibition reduced immune complex-mediated complement activation (C3c and soluble C5b-9 generation), cell surface deposition of immune complexes and cellular activation. Aims: As previous studies suggest that the alternative pathway (AP) provides significant amplification (>80%) of the CP pathway, (PMID: 15544620) we compared the effects of AP, CP, and CP/AP inhibitors by KKO and HIT immune complexes in whole blood. Methods: Inhibitors of the CP (BBK32, a borrelia protein inhibitor to C1r), AP (anti-factor B antibody (α-fB), or Factor D (fD inhibitor or fD-INH) Alexion Pharmaceuticals, Boston, MA) or combined AP/CP (C1-esterase inhibitor, C1-INH, Berinert, CSL Behring; or soluble complement receptor 1, sCR1, Alexion) were tested in hemolytic assays of CP or AP to confirm pathway specificity. To examine effects of CP or AP inhibition on complement activation by immune complexes consisting of KKO or HIT IgG, whole blood was pre-incubated with CP, AP or CP/AP inhibitors prior to addition of P+H ± KKO/HIT IgG or isotype controls. WB was incubated for 45 minutes at 37ºC followed by addition of 10mM EDTA to quench further complement activation. Complement activation products (C3c and sC5b-9) and neutrophil degranulation (MMP9) markers were measured using commercial immunoassays. Effects of complement inhibitors on cellular deposition of immune complexes was examined by flow, using previously described methods (PMID 34189574) using fluorescently labeled anti-C3c antibody (Quidel, San Diego, CA) and anti-mouse or human IgG (Biolegend, San Diego, CA). Results: Consistent with prior publications (PMID: 26808924), BBK32 showed marked reduction CP, but not AP-dependent hemolytic assays. The converse was true of AP inhibitors: α-fB and fD-INH prevented AP-dependent, but not CP-dependent hemolysis (data not shown). C1-INH and sCR1 showed activity in both CP- and AP-dependent assays. The CP or CP/AP inhibitors showed potent inhibition of C3c and sC5b-9 generation by KKO and HIT immune complexes, while AP inhibitors had no effect (Figure A for KKO C3c generation; and Table 1 for KKO/HIT C3c generation; sC5b-9 data not shown). For a given CP or CP/AP inhibitor, the concentrations leading to 50% inhibition (IC 50) were generally comparable for KKO and HIT immune complexes for C3c (Figure A and Table 1) and sC5b-9 generation (data not shown), with potency as follows: C1-INH>>BBK32>sCR1 (Table 1). On the other hand, the AP inhibitors, α-fB and fD-INH, showed no inhibitory activity in C3c (Figure A and Table 1)/sC5b-9 (data not shown) generation by KKO or HIT ULICs. As our recent studies indicate that complement activation is critical to cell surface deposition of immune complexes and cellular activation via FcgRIIA, we examined effects of complement inhibitors on IC deposition on B-cells and MMP9 release from neutrophils. CP or CP/AP inhibitors, but not AP inhibitors, reduced cell surface binding of immune complexes (Figure B) as well as MMP9 release (Figure C and Table 1). Conclusion: Together, these studies demonstrate that the AP has a minimal role in supporting complement activation by KKO/HIT ULICs. Future studies should examine CP inhibition as a therapeutic strategy for modulating the cellular activating effects of HIT antibodies. To what extent these findings apply to other immune complexes and/or CP activators requires further study. Funding Agency: NIH HL151730; α-fB antibody, fD inhibitor and sCR1 was provided by Alexion Pharmaceuticals, Boston, MA. BBK32 was provided by Dr. Brandon Garcia, East Carolina University, Greenville, NC. Figure 1 Figure 1. Disclosures Cines: Dova: Consultancy; Rigel: Consultancy; Treeline: Consultancy; Arch Oncol: Consultancy; Jannsen: Consultancy; Taventa: Consultancy; Principia: Other: Data Safety Monitoring Board. OffLabel Disclosure: C1-esterase inhibitor off label for HIT

Organizational Memory Studies (OMS) is limited by its managerialist, presentist preoccupation with the utility of memory for knowledge management. The dominant model of memory in OMS is that of a storage bin. But this model has been rejected by psychologists because it overlooks the distinctly human subjective experience of remembering, i.e. episodic memory. OMS also fails to take account of the specific social and historical contexts of organizational memory. The methodological individualism that is prevalent in OMS makes it difficult to engage with the rapidly expanding sociological and historical literature in social memory studies, where a more social constructionist approach to ‘collective memory’ is generally favoured. However, for its part social memory studies derived from Maurice Halbwachs neglects organizations, focusing primarily on the nation as a mnemonic community. From a critical perspective organizations can be seen as appropriating society’s memory through corporate sites of memory such as historical visitor attractions and corporate museums. There is scope for a sociological and historical reorientation within OMS, drawing on social memory studies and focusing on corporate sites of memory, such as The Henry Ford museum complex, as well as the mnemonic role of founders and beginnings in organizations. Taking a social constructionist, collectivist approach to social remembering in organizations allows connections to be made between memory and other research programmes, such as organizational culture studies.

Organizations are increasingly being called to account for their history. In particular, German and non-German companies have been called to account for their relations with the Nazi regime between 1933 and 1945. Organizations are not only accountable for past activity, but also for previous, often misleading, historical accounts of their behaviour. Thus we are interested in how an organization deals with historical accounts of its past, and how this reflects its culture. Therefore we draw upon concepts from organizational culture studies, and specifically Martin's three perspectives of culture as integration, differentiation, and fragmentation. We take the illustrative case of Bertelsmann, the German publishing company. Revelations of its record under the Nazis, when it published anti-semitic literature, were brought to light by Hersch Fischler in 1998, when Bertelsmann was in the process of taking over Random House. These revelations jarred with the company's image of corporate social responsibility and undermined the company legend, which alleged that it had an impeccable record, and had even been closed down for opposing the Nazis. The Bertelsmann case highlights the dilemmas involved in organizations invoking their past. Debate over the Holocaust has highlighted the dilemmas of truth and relativism in representations of history. The Bertelsmann case highlights similar dilemmas for organizational culture perspectives.

Does history matter in strategy? The lack of attention given to historical perspectives in the mainstream literature suggests that it does not. Recently, however, authors have argued that historical forces do affect the strategic management of organizations, and have highlighted their importance through the concept of “path dependence”. I review the literature on path dependence and argue that a conception of the complexities of historical understanding is required in a dynamic understanding of organizations. To highlight these complexities, I review an important theme in twentieth century historiography: the possibilities and problems presented by counterfactual analysis. Despite some serious objections to counterfactual thinking, this method may yield benefits for both managers and theorists. I conclude that to do justice to the importance of history in organizations, we must follow Collingwood in engaging, not with the question “Shall I be a historian or not?”, but rather with the question, “How good a historian shall I be?”.

Spectral measurements of biologically relevant radiation at McMurdo Station, Antarctica reveal ultraviolet (UV) irradiance levels at 305 nm in October exceeding by a factor between 3 and 6 “normal” values expected for undepleted ozone levels. This enhancement is directly related to the ozone depletion. The column abundance of stratospheric ozone derived from these measurements was as low as 145 Dobson Units (DU) in October, 1990. This is more than a factor of 2 lower than the value at solstice, and 100 DU less than in October, 1988. The dose rate for damage to the DNA molecule based on Setlow's action spectrum and UV radiation measured at noon is well above normal levels most of the time between October 1 and December 5 and is as much as three times the normal value for a few days at the end of October.

Spectral measurements of solar ultraviolet (UV) radiation taken at McMurdo Station, Antarctica are used to determine biologically effective UV dose, ozone column content, and effective cloud optical depth. The seasonal variation in these parameters from September 15, 1988 through April 15, 1989 is presented and discussed. Although no days from September 15 through October experienced UV dose exceeding that occurring at summer solstice, the temporal variation in the level of UV radiation is markedly asymmetric with respect to summer solstice. A general enhancement by about 20% in biologically effective UV dose in October, 1988 compared to March, 1989 is clearly evident. The main cause of this asymmetry appears to be the coincident deficiency in ozone abundance appears to be the coincident deficiency in ozone abundance by about 8% in spring compared to fall. The percent increase in UV dose per percent decrease in ozone abundance is about 2.5 in agreement with theoretical predictions. The total ozone amount is generally depleted (to about 250 DU) during October 1988, but there are large day-to-day fluctuations. Presumably these fluctuations are caused primarily by the motion of the polar vortex. After summer solstice UV radiation levels and ozone amounts exhibit much less pronounced day-to-daymore » fluctuations. No spring/fall asymmetry in cloudiness, as it affects the surface ultraviolet radiation budget, is discernible from the measurements if the surface albedo is assumed to vary symmetrically around solstice.« less

Las empresas suelen anunciar públicamente su longevidad. Para ellas, el pasado tiene un significado claro. Sin embargo, las teorías de la organización que consideran la pervivencia y el papel representado por los fundadores, sobre todo las de tipo ecológico y cultural, no explican los significados colectivos que van unidos al pasado. Tampoco lo hace la literatura sobre la memoria de las organizaciones, que la concibe como una serie de compartimentos estancos. La Historia empresarial se preocupa más por la reconstrucción del pasado desde el momento presente que por los significados implícitos en el pasado. Con el fin de comprender las prácticas sociales (mnemónicas) por las que el pasado es recordado y por las que cobra sentido, nosotros recurrimos al cada vez más importante campo de la memoria social. Para examinar el modo en el que las interpretaciones oficiales están presentes en el pasado de las organizaciones, nos servimos de documentos públicamente disponibles, como memorias de las compañías, informes de prensa, artículos o historias hechas por encargo. Partiendo de los puntos de vista de la memoria social, nos centramos en analizar los centenarios y la creación de lugares de memoria, así como en el tradicional debate sobre la condición histórica de memorias que vertebran la identidad. En el texto, proporcionamos breves ejemplos sobre la celebración del centenario de la Ford, la denominación del centro de formación de directivos de la General Electric como John F. Welch Learning Center, así como de la desacreditadora leyenda de la Bertelsmann, concerniente a su comportamiento durante el dominio nazi en Alemania. Concluimos que el punto de vista de la memoria social puede constituir una base idónea para investigar el significado del pasado en las organizaciones.

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