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33 results on '"Chang, Seung-Cheol"'

9. Graphene quantum dot nanocomposites: electroanalytical and optical sensor technology perspective.

Author

Ja'farawy, Muhammad Shalahuddin Al, Thirumalai, Dinakaran, Lee, Jaewon, Jung, Ho Sang, Chang, Seung-Cheol, Yoon, Jang-Hee, and Kim, Dong-Ho

Subjects
OPTICAL sensors, NANOCOMPOSITE materials, GRAPHENE, ELECTRON mobility, NEURODEGENERATION
Abstract

Electroanalytical and optical techniques are widely used in the development of nanomaterials-based sensor platforms. These techniques have a quick response, high sensitivity, and selectivity. Electroanalytical and optical techniques are widely used in the development of nanomaterial-based sensor platforms. These sensors must be able to detect biomarkers, pathogens, toxins, and pharmaceuticals in biological matrices associated with cardiovascular disease, cancer, and neurodegenerative diseases. Considering these pathophysiologies, numerous investigations have been undertaken to develop sensors for early diagnosis and treatment, utilizing nanomaterials such as quantum dots. Graphene quantum dots (GQDs), which are ideally nanometer-sized graphene fragments, have recently received increased attention due to their excellent physicochemical properties such as fast electron mobility, photostability, water solubility, biocompatibility, high specific surface area, and nontoxicity. Apart from the properties mentioned above, GQDs provide π–π interactions, electrostatic, and covalent interactions with an analyte, and ease of synthesis as well as the ability to combine with other nanomaterials, which have enabled their use in various sensing platforms. This review summarizes recent advances in GQDs-based nanocomposites for sensor applications, with a focus on electroanalytical and optical techniques, as well as current challenges and future prospects. [ABSTRACT FROM AUTHOR]

Published
2023
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13. Anti-Inflammatory Effects of the Novel Barbiturate Derivative MHY2699 in an MPTP-Induced Mouse Model of Parkinson’s Disease

Author

Lee, Seulah, primary, Suh, Yeon Ji, additional, Lee, Yujeong, additional, Yang, Seonguk, additional, Hong, Dong Geun, additional, Thirumalai, Dinakaran, additional, Chang, Seung-Cheol, additional, Chung, Ki Wung, additional, Jung, Young-Suk, additional, Moon, Hyung Ryong, additional, Chung, Hae Young, additional, and Lee, Jaewon, additional

Published
2021
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25. Graphene quantum dot nanocomposites: electroanalytical and optical sensor technology perspective

Author

Ja’farawy, Muhammad Shalahuddin Al, Thirumalai, Dinakaran, Lee, Jaewon, Jung, Ho Sang, Chang, Seung-Cheol, Yoon, Jang-Hee, and Kim, Dong-Ho

Abstract

Electroanalytical and optical techniques are widely used in the development of nanomaterials-based sensor platforms. These techniques have a quick response, high sensitivity, and selectivity. Electroanalytical and optical techniques are widely used in the development of nanomaterial-based sensor platforms. These sensors must be able to detect biomarkers, pathogens, toxins, and pharmaceuticals in biological matrices associated with cardiovascular disease, cancer, and neurodegenerative diseases. Considering these pathophysiologies, numerous investigations have been undertaken to develop sensors for early diagnosis and treatment, utilizing nanomaterials such as quantum dots. Graphene quantum dots (GQDs), which are ideally nanometer-sized graphene fragments, have recently received increased attention due to their excellent physicochemical properties such as fast electron mobility, photostability, water solubility, biocompatibility, high specific surface area, and nontoxicity. Apart from the properties mentioned above, GQDs provide π–πinteractions, electrostatic, and covalent interactions with an analyte, and ease of synthesis as well as the ability to combine with other nanomaterials, which have enabled their use in various sensing platforms. This review summarizes recent advances in GQDs-based nanocomposites for sensor applications, with a focus on electroanalytical and optical techniques, as well as current challenges and future prospects.

Published
2023
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33. Comparisons of platinum, gold, palladium and glassy carbon as electrode materials in the design of biosensors for glutamate.

Author

O'Neill RD, Chang SC, Lowry JP, and McNeil CJ

Subjects
Ascorbic Acid, Catechols, Electrodes, Biosensing Techniques instrumentation, Carbon, Glutamic Acid analysis, Gold, Palladium, Platinum
Abstract

Four electrode materials: Pt, Au, Pd and glassy carbon (GC), were studied to investigate their suitability as substrates in the development of two different classes of glutamate biosensor. Glutamate oxidase cross-linked onto poly(o-phenylenediamine) was chosen as the type 1 biosensor (PPD/GluOx), incorporating PPD as the permselective element to detect H(2)O(2) directly on the electrode surface at relatively high applied potentials. GluOx and horseradish peroxidase/redox polymer modified electrodes (Os(2+)PVP/HRP/GluOx) that relied on enzyme-catalysed H(2)O(2) detection at lower applied potentials were used as type 2 biosensors. The voltammetric and amperometric responses to the enzyme signal transduction molecule, H(2)O(2), and the archetypal interference species in biological applications, ascorbic acid, were determined on the bare and PPD/GluOx-modified surfaces. The amperometric responses of these electrodes were stable over several days of continuous recording in phosphate buffered saline (pH 7.4). The sensitivity of the type 1 biosensors to H(2)O(2) and glutamate showed parallel trends with low limits of detection and good linearity at low concentrations: Pt>Au approximately Pd>>GC. Type 2 biosensors out-performed the type 1 design for all electrode substrates, except Pt. However, the presence of the permselective PPD membrane in the type 1 biosensors, not feasible in the type 2 design, suggests that Pt/PPD/GluOx might have the best all-round characteristics for glutamate detection in biological media containing interference species such as ascorbic acid. Other points affecting a final choice of substrate should include factors such as mass production issues.

Published
2004
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