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1. Polymorphisms in transcription factor binding sites and enhancer regions and pancreatic ductal adenocarcinoma risk

Author

Ünal, Pelin, Lu, Ye, Bueno-de-Mesquita, Bas, van Eijck, Casper H. J., Talar-Wojnarowska, Renata, Szentesi, Andrea, Gazouli, Maria, Kreivenaite, Edita, Tavano, Francesca, Małecka-Wojciesko, Ewa, Erőss, Bálint, Oliverius, Martin, Bunduc, Stefania, Nóbrega Aoki, Mateus, Vodickova, Ludmila, Boggi, Ugo, Giaccherini, Matteo, Kondrackiene, Jurate, Chammas, Roger, Palmieri, Orazio, Theodoropoulos, George E., Bijlsma, Maarten F., Basso, Daniela, Mohelnikova-Duchonova, Beatrice, Soucek, Pavel, Izbicki, Jakob R., Kiudelis, Vytautas, Vanella, Giuseppe, Arcidiacono, Paolo Giorgio, Włodarczyk, Barbara, Hackert, Thilo, Schöttker, Ben, Uzunoglu, Faik G., Bambi, Franco, Goetz, Mara, Hlavac, Viktor, Brenner, Hermann, Perri, Francesco, Carrara, Silvia, Landi, Stefano, Hegyi, Péter, Dijk, Frederike, Maiello, Evaristo, Capretti, Giovanni, Testoni, Sabrina Gloria Giulia, Petrone, Maria Chiara, Stocker, Hannah, Ermini, Stefano, Archibugi, Livia, Gentiluomo, Manuel, Cavestro, Giulia Martina, Pezzilli, Raffaele, Di Franco, Gregorio, Milanetto, Anna Caterina, Sperti, Cosimo, Neoptolemos, John P., Morelli, Luca, Vokacova, Klara, Pasquali, Claudio, Lawlor, Rita T., Bazzocchi, Francesca, Kupcinskas, Juozas, Capurso, Gabriele, Campa, Daniele, and Canzian, Federico

Published
2024
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4. Exploring the Neandertal legacy of pancreatic ductal adenocarcinoma risk in Eurasians

Author

Piccardi, Margherita, Gentiluomo, Manuel, Bertoncini, Stefania, Pezzilli, Raffaele, Erőss, Bálint, Bunduc, Stefania, Uzunoglu, Faik G., Talar-Wojnarowska, Renata, Vanagas, Tomas, Sperti, Cosimo, Oliverius, Martin, Aoki, Mateus Nóbrega, Ermini, Stefano, Hussein, Tamás, Boggi, Ugo, Jamroziak, Krzysztof, Maiello, Evaristo, Morelli, Luca, Vodickova, Ludmila, Di Franco, Gregorio, Landi, Stefano, Szentesi, Andrea, Lovecek, Martin, Puzzono, Marta, Tavano, Francesca, van Laarhoven, Hanneke W. M., Zerbi, Alessandro, Mohelnikova-Duchonova, Beatrice, Stocker, Hannah, Costello, Eithne, Capurso, Gabriele, Ginocchi, Laura, Lawlor, Rita T., Vanella, Giuseppe, Bazzocchi, Francesca, Izbicki, Jakob R., Latiano, Anna, Bueno-de-Mesquita, Bas, Ponz de Leon Pisani, Ruggero, Schöttker, Ben, Soucek, Pavel, Hegyi, Péter, Gazouli, Maria, Hackert, Thilo, Kupcinskas, Juozas, Poskiene, Lina, Tacelli, Matteo, Roth, Susanne, Carrara, Silvia, Perri, Francesco, Hlavac, Viktor, Theodoropoulos, George E., Busch, Olivier R., Mambrini, Andrea, van Eijck, Casper H. J., Arcidiacono, Paolo, Scarpa, Aldo, Pasquali, Claudio, Basso, Daniela, Lucchesi, Maurizio, Milanetto, Anna Caterina, Neoptolemos, John P., Cavestro, Giulia Martina, Janciauskas, Dainius, Chen, Xuechen, Chammas, Roger, Goetz, Mara, Brenner, Hermann, Archibugi, Livia, Dannemann, Michael, Canzian, Federico, Tofanelli, Sergio, and Campa, Daniele

Published
2023
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5. The PANcreatic Disease ReseArch (PANDoRA) consortium: Ten years’ experience of association studies to understand the genetic architecture of pancreatic cancer

Author

Campa, Daniele, Gentiluomo, Manuel, Stein, Angelika, Aoki, Mateus Nóbrega, Oliverius, Martin, Vodičková, Ludmila, Jamroziak, Krzysztof, Theodoropoulos, George, Pasquali, Claudio, Greenhalf, William, Arcidiacono, Paolo Giorgio, Uzunoglu, Faik, Pezzilli, Raffaele, Luchini, Claudio, Puzzono, Marta, Loos, Martin, Giaccherini, Matteo, Katzke, Verena, Mambrini, Andrea, Kiudeliene, Edita, Federico, Kauffmann Emanuele, Johansen, Julia, Hussein, Tamás, Mohelnikova-Duchonova, Beatrice, van Eijck, Casper H.J., Brenner, Hermann, Farinella, Riccardo, Pérez, Juan Sainz, Lovecek, Martin, Büchler, Markus W., Hlavac, Viktor, Izbicki, Jakob R., Hackert, Thilo, Chammas, Roger, Zerbi, Alessandro, Lawlor, Rita, Felici, Alessio, Götz, Mara, Capurso, Gabriele, Ginocchi, Laura, Gazouli, Maria, Kupcinskas, Juozas, Cavestro, Giulia Martina, Vodicka, Pavel, Moz, Stefania, Neoptolemos, John P., Kunovsky, Lumir, Bojesen, Stig E., Carrara, Silvia, Gioffreda, Domenica, Morkunas, Egidijus, Abian, Olga, Bunduc, Stefania, Basso, Daniela, Boggi, Ugo, Wlodarczyk, Barbara, Szentesi, Andrea, Vanella, Giuseppe, Chen, Inna, Bijlsma, Maarten F., Kiudelis, Vytautas, Landi, Stefano, Schöttker, Ben, Corradi, Chiara, Giese, Nathalia, Kaaks, Rudolf, Peduzzi, Giulia, Hegyi, Péter, Morelli, Luca, Furbetta, Niccolò, Soucek, Pavel, Latiano, Anna, Talar-Wojnarowska, Renata, Lindgaard, Sidsel C., Dijk, Frederike, Milanetto, Anna Caterina, Tavano, Francesca, Cervena, Klara, Erőss, Bálint, Testoni, Sabrina G., Verhagen-Oldenampsen, Judith H.E., Małecka-Wojciesko, Ewa, Costello, Eithne, Salvia, Roberto, Maiello, Evaristo, Ermini, Stefano, Sperti, Cosimo, Holleczek, Bernd, Perri, Francesco, Skieceviciene, Jurgita, Archibugi, Livia, Lucchesi, Maurizio, Rizzato, Cosmeri, and Canzian, Federico

Published
2023
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6. Altered galectin-3 distribution and migratory function in the pre-diabetic non-obese diabetic mouse thymus.

Author

Pereira Ramos, Tiago Dutra, Marques Ventura, Ana Lucia, Pereira Lemos, Julia, Chammas, Roger, Savino, Wilson, Eponina Carvalho-Pinto, Carla, Arêas Mendes-da-Cruz, Daniella, and Serra Villa-Verde, Déa Maria

Subjects
ANIMAL development, TYPE 1 diabetes, B cells, GALECTINS, EXTRACELLULAR matrix, T cells
Abstract

Galectin-3 is an endogenous lectin which binds mainly to β-galactosides on the cell surface and extracellular matrix (ECM) glycoproteins. In the thymus, this lectin is constitutively expressed, being involved in thymocyte adhesion, migration, and death. Galectin-3 has been related to type 1 diabetes, an autoimmune disease characterized by pancreatic β-cell destruction mediated by autoreactive T lymphocytes. Non-obese diabetic (NOD) mice represent a suitable model to study type 1 diabetes, as they develop the disease like humans. We previously described important thymic alterations in these animals such as the development of giant perivascular spaces (PVS), characterized by the retention of T and B cells, intermingled with an ECM network, and associated with a defect in the expression of the fibronectin receptor VLA-5 and reduced sphingosine-1-phosphate receptor expression on developing thymocytes. In order to investigate galectin-3 expression in thymic microenvironmental cells and verify its interaction with cells and ECM molecules in PVS, we performed immunofluorescence following colocalization analysis in the thymic parenchyma of pre-diabetic NOD mice by confocal microscopy. In addition, thymocyte migration assays were performed to evaluate the effect of galectin-3 on NOD thymocyte migration. Herein, we showed a significant enhancement of colocalization with cortical and medullary thymic epithelial cells in NOD mice, as compared to controls. In the giant PVS of these animals, we observed a heterogeneous distribution of galectin-3, predominantly found in clusters of B lymphocytes and dendritic cells. Functionally, NOD thymocyte migratory response towards galectin-3 was impaired and a similar decrease was seen in transendothelial thymocyte migration. Taken together, our data provide the histological and functional background for a potential defective thymocyte migration involving galectin-3, thus placing this molecule as a further player in the intrathymic disturbances observed in pre-diabetic NOD mice. [ABSTRACT FROM AUTHOR]

Published
2024
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7. Somatic mutations in early onset luminal breast cancer

Author

Encinas, Giselly, Sabelnykova, Veronica Y, de Lyra, Eduardo Carneiro, Katayama, Maria Lucia Hirata, Maistro, Simone, de Vasconcellos Valle, Pedro Wilson Mompean, de Lima Pereira, Gláucia Fernanda, Rodrigues, Lívia Munhoz, de Menezes Pacheco Serio, Pedro Adolpho, de Gouvêa, Ana Carolina Ribeiro Chaves, Geyer, Felipe Correa, Basso, Ricardo Alves, Pasini, Fátima Solange, del Pilar Esteves Diz, Maria, Brentani, Maria Mitzi, Góes, João Carlos Guedes Sampaio, Chammas, Roger, Boutros, Paul C, and Folgueira, Maria Aparecida Azevedo Koike

Subjects
Human Genome, Genetics, Genetic Testing, Breast Cancer, Cancer, breast cancer, germline mutation, luminal subtype, somatic mutation, young patients, Oncology and Carcinogenesis
Abstract

Breast cancer arising in very young patients may be biologically distinct; however, these tumors have been less well studied. We characterized a group of very young patients (≤ 35 years) for BRCA germline mutation and for somatic mutations in luminal (HER2 negative) breast cancer. Thirteen of 79 unselected very young patients were BRCA1/2 germline mutation carriers. Of the non-BRCA tumors, eight with luminal subtype (HER2 negative) were submitted for whole exome sequencing and integrated with 29 luminal samples from the COSMIC database or previous literature for analysis. We identified C to T single nucleotide variants (SNVs) as the most common base-change. A median of six candidate driver genes was mutated by SNVs in each sample and the most frequently mutated genes were PIK3CA, GATA3, TP53 and MAP2K4. Potential cancer drivers affected in the present non-BRCA tumors include GRHL2, PIK3AP1, CACNA1E, SEMA6D, SMURF2, RSBN1 and MTHFD2. Sixteen out of 37 luminal tumors (43%) harbored SNVs in DNA repair genes, such as ATR, BAP1, ERCC6, FANCD2, FANCL, MLH1, MUTYH, PALB2, POLD1, POLE, RAD9A, RAD51 and TP53, and 54% presented pathogenic mutations (frameshift or nonsense) in at least one gene involved in gene transcription. The differential biology of luminal early-age onset breast cancer needs a deeper genomic investigation.

Published
2018

9. STAT3 contributes to cisplatin resistance, modulating EMT markers, and the mTOR signaling in lung adenocarcinoma

Author

Morelli, Ana Paula, Tortelli, Tharcísio Citrângulo, Jr, Mancini, Mariana Camargo Silva, Pavan, Isadora Carolina Betim, Silva, Luiz Guilherme Salvino, Severino, Matheus Brandemarte, Granato, Daniela Campos, Pestana, Nathalie Fortes, Ponte, Luis Gustavo Saboia, Peruca, Guilherme Francisco, Pauletti, Bianca Alves, dos Santos, Daniel Francisco Guimarães, Jr, de Moura, Leandro Pereira, Bezerra, Rosângela Maria Neves, Leme, Adriana Franco Paes, Chammas, Roger, and Simabuco, Fernando Moreira

Published
2021
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10. Editorial: Pharmacology of gangliosides.

Author

Hongda Zhuang, Zhendong Huang, Birklé, Stéphane, Chammas, Roger, Tikkanen, Ritva, and Yong Chen

Subjects
CELL receptors, TARGETED drug delivery, LIPID rafts, CHIMERIC antigen receptors, PROGNOSIS, MONOCLONAL antibodies, BISPECIFIC antibodies, GLYCOCALYX
Abstract

This editorial, titled "Pharmacology of gangliosides," explores the potential of gangliosides as therapeutic targets and diagnostic biomarkers. Gangliosides are glycosphingolipids found on the surfaces of vertebrate cells and are involved in various diseases, including cancer, neurological disorders, infections, metabolic disorders, autoimmune diseases, and cardiovascular diseases. The editorial provides an overview of recent research on gangliosides, including their role as cancer biomarkers, targeted therapies, enhanced effect of immunotherapy, and drug delivery systems. It highlights the importance of further research into gangliosides in tumor biology and the exploration of other gangliosides beyond GD2 and GD3. The author contributions, funding, acknowledgments, conflict of interest, and publisher's note are also mentioned. [Extracted from the article]

Published
2024
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12. Exercise training reverses cancer-induced oxidative stress and decrease in muscle COPS2/TRIP15/ALIEN

Author

Alves, Christiano R.R., Neves, Willian das, de Almeida, Ney R., Eichelberger, Eric J., Jannig, Paulo R., Voltarelli, Vanessa A., Tobias, Gabriel C., Bechara, Luiz R.G., de Paula Faria, Daniele, Alves, Maria J.N., Hagen, Lars, Sharma, Animesh, Slupphaug, Geir, Moreira, José B.N., Wisloff, Ulrik, Hirshman, Michael F., Negrão, Carlos E., de Castro Jr, Gilberto, Chammas, Roger, Swoboda, Kathryn J., Ruas, Jorge L., Goodyear, Laurie J., and Brum, Patricia C.

Published
2020
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13. Data-driven, cross-disciplinary collaboration: lessons learned at the largest academic health center in Latin America during the COVID-19 pandemic

Author

Ritto, Ana Paula, primary, de Araujo, Adriana Ladeira, additional, de Carvalho, Carlos Roberto Ribeiro, additional, De Souza, Heraldo Possolo, additional, Favaretto, Patricia Manga e Silva, additional, Saboya, Vivian Renata Boldrim, additional, Garcia, Michelle Louvaes, additional, Kulikowski, Leslie Domenici, additional, Kallás, Esper Georges, additional, Pereira, Antonio José Rodrigues, additional, Cobello Junior, Vilson, additional, Silva, Katia Regina, additional, Abdalla, Eidi Raquel Franco, additional, Segurado, Aluisio Augusto Cotrim, additional, Sabino, Ester Cerdeira, additional, Ribeiro Junior, Ulysses, additional, Francisco, Rossana Pulcineli Vieira, additional, Miethke-Morais, Anna, additional, Levin, Anna Sara Shafferman, additional, Sawamura, Marcio Valente Yamada, additional, Ferreira, Juliana Carvalho, additional, Silva, Clovis Artur, additional, Mauad, Thais, additional, Gouveia, Nelson da Cruz, additional, Letaif, Leila Suemi Harima, additional, Bego, Marco Antonio, additional, Battistella, Linamara Rizzo, additional, Duarte, Alberto José da Silva, additional, Seelaender, Marilia Cerqueira Leite, additional, Marchini, Julio, additional, Forlenza, Orestes Vicente, additional, Rocha, Vanderson Geraldo, additional, Mendes-Correa, Maria Cassia, additional, Costa, Silvia Figueiredo, additional, Cerri, Giovanni Guido, additional, Bonfá, Eloisa Silva Dutra de Oliveira, additional, Chammas, Roger, additional, de Barros Filho, Tarcisio Eloy Pessoa, additional, and Busatto Filho, Geraldo, additional

Published
2024
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16. Development of a Prognostic Model for Early Breast Cancer Integrating Neutrophil to Lymphocyte Ratio and Clinical-Pathological Characteristics.

Author

Faria, Sara Socorro, Giannarelli, Diana, Lima, Vladmir Claudio Cordeiro de, Anwar, Sumadi Luckman, Casadei, Chiara, Giorgi, Ugo De, Madonna, Gabriele, Ascierto, Paolo Antonio, López, Rossana Veronica Mendoza, Chammas, Roger, and Capone, Mariaelena

Subjects
BREAST cancer prognosis, NEUTROPHIL lymphocyte ratio, BREAST tumors, EARLY detection of cancer, TUMOR markers, SYMPTOMS, DESCRIPTIVE statistics, PROGRESSION-free survival
Abstract

Background Breast cancer-related inflammation is critical in tumorigenesis, cancer progression, and patient prognosis. Several inflammatory markers derived from peripheral blood cells count, such as the neutrophil-lymphocyte ratio (NLR), platelet-lymphocyte ratio (PLR), monocyte-lymphocyte ratio (MLR), and systemic immune-inflammation index (SII) are considered as prognostic markers in several types of malignancy. Methods We investigate and validate a prognostic model in early patients with breast cancer to predict disease-free survival (DFS) based on readily available baseline clinicopathological prognostic factors and preoperative peripheral blood-derived indexes. Results We analyzed a training cohort of 710 patients and 2 external validation cohorts of 980 and 157 patients with breast cancer, respectively, with different demographic origins. An elevated preoperative NLR is a better DFS predictor than others scores. The prognostic model generated in this study was able to classify patients into 3 groups with different risks of relapse based on ECOG-PS, presence of comorbidities, T and N stage, PgR status, and NLR. Conclusion Prognostic models derived from the combination of clinicopathological features and peripheral blood indices, such as NLR, represent attractive markers mainly because they are easily detectable and applicable in daily clinical practice. More comprehensive prospective studies are needed to unveil their actual effectiveness. [ABSTRACT FROM AUTHOR]

Published
2024
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17. A novel program of infiltrative control in astrocytomas: ADAM23 depletion promotes cell invasion by activating γ-Secretase complex

Author

Jandrey, Elisa Helena Farias, primary, Barnabé, Gabriela Filoso, additional, Maldaun, Marcos, additional, Asprino, Paula Fontes, additional, dos Santos, Natália Cristina, additional, Inoue, Lilian Tiemi, additional, Rozanski, Andrei, additional, Galante, Pedro Alexandre Favoretto, additional, Marie, Suely Kazue Nagahashi, additional, Oba-Shinjo, Sueli Mieko, additional, dos Santos, Tiago Góss, additional, Chammas, Roger, additional, Lancellotti, Carmen Lucia Penteado, additional, Furnari, Frank B, additional, Camargo, Anamaria Aranha, additional, and Costa, Érico Tosoni, additional

Published
2023
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19. Frequency of CDH1 germline variants and contribution of dietary habits in early age onset gastric cancer patients in Brazil

Author

Guindalini, Rodrigo Santa Cruz, Cormedi, Marina Cândido Visontai, Maistro, Simone, Pasini, Fátima Solange, Branas, Priscila Cristina Abduch Adas, dos Santos, Liliane, de Lima Pereira, Gláucia Fernanda, de Bock, Geertruida Hendrika, Saccaro, Daniela Marques, Katayama, Maria Lucia Hirata, Faraj, Sheila Friedrich, Safatle-Ribeiro, Adriana, Ribeiro Junior, Ulysses, Diz, Maria Del Pilar Estevez, de Gouvêa, Ana Carolina Ribeiro Chaves, Chammas, Roger, and Folgueira, Maria Aparecida Azevedo Koike

Published
2019
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21. Screening of Exosome-Derived Proteins and Their Potential as Biomarkers in Diagnostic and Prognostic for Pancreatic Cancer

Author

Marin, Anelis Maria, primary, Batista, Michel, additional, Korte de Azevedo, Alexandre Luiz, additional, Bombardelli Gomig, Talita Helen, additional, Soares Caldeira Brant, Rodrigo, additional, Chammas, Roger, additional, Uno, Miyuki, additional, Dias Araújo, Diogo, additional, Zanette, Dalila Luciola, additional, and Nóbrega Aoki, Mateus, additional

Published
2023
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23. Modulation of stress and immune response by Amblyomin-X results in tumor cell death in a horse melanoma model

Author

Lichtenstein, Flavio, Iqbal, Asif, de Lima Will, Sonia Elisabete Alves, Bosch, Rosemary Viola, DeOcesano-Pereira, Carlos, Goldfeder, Mauricio Barbugiani, Chammas, Roger, Trufen, Carlos Eduardo Madureira, Morais, Katia Luciano Pereira, de Souza, Jean Gabriel, Natalino, Renato Jose Mendonça, de Azevedo, Inacio Junqueira, Nishiyama Junior, Milton Yutaka, Oliveira, Ursula, Alves, Francisco Ivanio Arruda, Araujo, Jaqueline Mayara, Lobba, Aline Ramos Maia, and Chudzinski-Tavassi, Ana Marisa

Published
2020
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25. Polymorphic variants involved in methylation regulation: a strategy to discover risk loci for pancreatic ductal adenocarcinoma

Author

Corradi, Chiara, primary, Lencioni, Giulia, additional, Gentiluomo, Manuel, additional, Felici, Alessio, additional, Latiano, Anna, additional, Kiudelis, Gediminas, additional, van Eijck, Casper H J, additional, Marta, Katalin, additional, Lawlor, Rita T, additional, Tavano, Francesca, additional, Boggi, Ugo, additional, Dijk, Frederike, additional, Cavestro, Giulia Martina, additional, Vermeulen, Roel C H, additional, Hackert, Thilo, additional, Petrone, Maria Chiara, additional, Uzunoğlu, Faik Güntac, additional, Archibugi, Livia, additional, Izbicki, Jakob R, additional, Morelli, Luca, additional, Zerbi, Alessandro, additional, Landi, Stefano, additional, Stocker, Hannah, additional, Talar-Wojnarowska, Renata, additional, Di Franco, Gregorio, additional, Hegyi, Péter, additional, Sperti, Cosimo, additional, Carrara, Silvia, additional, Capurso, Gabriele, additional, Gazouli, Maria, additional, Brenner, Hermann, additional, Bunduc, Stefania, additional, Busch, Olivier, additional, Perri, Francesco, additional, Oliverius, Martin, additional, Hegyi, Péter Jeno, additional, Goetz, Mara, additional, Scognamiglio, Pasquale, additional, Mambrini, Andrea, additional, Arcidiacono, Paolo Giorgio, additional, Kreivenaite, Edita, additional, Kupcinskas, Juozas, additional, Hussein, Tamas, additional, Ermini, Stefano, additional, Milanetto, Anna Caterina, additional, Vodicka, Pavel, additional, Kiudelis, Vytautas, additional, Hlaváč, Viktor, additional, Soucek, Pavel, additional, Theodoropoulos, George E, additional, Basso, Daniela, additional, Neoptolemos, John P, additional, Nóbrega Aoki, Mateus, additional, Pezzilli, Raffaele, additional, Pasquali, Claudio, additional, Chammas, Roger, additional, Testoni, Sabrina Gloria Giulia, additional, Mohelnikova-Duchonova, Beatrice, additional, Lucchesi, Maurizio, additional, Rizzato, Cosmeri, additional, Canzian, Federico, additional, and Campa, Daniele, additional

Published
2023
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26. Polymorphic variants involved in methylation regulation: a strategy to discover risk loci for pancreatic ductal adenocarcinoma

Author

Corradi, Chiara, Lencioni, Giulia, Gentiluomo, Manuel, Felici, Alessio, Latiano, Anna, Kiudelis, Gediminas, van Eijck, Casper H J, Marta, Katalin, Lawlor, Rita T, Tavano, Francesca, Boggi, Ugo, Dijk, Frederike, Cavestro, Giulia Martina, Vermeulen, Roel C H, Hackert, Thilo, Petrone, Maria Chiara, Uzunoğlu, Faik Güntac, Archibugi, Livia, Izbicki, Jakob R, Morelli, Luca, Zerbi, Alessandro, Landi, Stefano, Stocker, Hannah, Talar-Wojnarowska, Renata, Di Franco, Gregorio, Hegyi, Péter, Sperti, Cosimo, Carrara, Silvia, Capurso, Gabriele, Gazouli, Maria, Brenner, Hermann, Bunduc, Stefania, Busch, Olivier, Perri, Francesco, Oliverius, Martin, Hegyi, Péter Jeno, Goetz, Mara, Scognamiglio, Pasquale, Mambrini, Andrea, Arcidiacono, Paolo Giorgio, Kreivenaite, Edita, Kupcinskas, Juozas, Hussein, Tamas, Ermini, Stefano, Milanetto, Anna Caterina, Vodicka, Pavel, Kiudelis, Vytautas, Hlaváč, Viktor, Soucek, Pavel, Theodoropoulos, George E, Basso, Daniela, Neoptolemos, John P, Nóbrega Aoki, Mateus, Pezzilli, Raffaele, Pasquali, Claudio, Chammas, Roger, Testoni, Sabrina Gloria Giulia, Mohelnikova-Duchonova, Beatrice, Lucchesi, Maurizio, Rizzato, Cosmeri, Canzian, Federico, Campa, Daniele, Corradi, Chiara, Lencioni, Giulia, Gentiluomo, Manuel, Felici, Alessio, Latiano, Anna, Kiudelis, Gediminas, van Eijck, Casper H J, Marta, Katalin, Lawlor, Rita T, Tavano, Francesca, Boggi, Ugo, Dijk, Frederike, Cavestro, Giulia Martina, Vermeulen, Roel C H, Hackert, Thilo, Petrone, Maria Chiara, Uzunoğlu, Faik Güntac, Archibugi, Livia, Izbicki, Jakob R, Morelli, Luca, Zerbi, Alessandro, Landi, Stefano, Stocker, Hannah, Talar-Wojnarowska, Renata, Di Franco, Gregorio, Hegyi, Péter, Sperti, Cosimo, Carrara, Silvia, Capurso, Gabriele, Gazouli, Maria, Brenner, Hermann, Bunduc, Stefania, Busch, Olivier, Perri, Francesco, Oliverius, Martin, Hegyi, Péter Jeno, Goetz, Mara, Scognamiglio, Pasquale, Mambrini, Andrea, Arcidiacono, Paolo Giorgio, Kreivenaite, Edita, Kupcinskas, Juozas, Hussein, Tamas, Ermini, Stefano, Milanetto, Anna Caterina, Vodicka, Pavel, Kiudelis, Vytautas, Hlaváč, Viktor, Soucek, Pavel, Theodoropoulos, George E, Basso, Daniela, Neoptolemos, John P, Nóbrega Aoki, Mateus, Pezzilli, Raffaele, Pasquali, Claudio, Chammas, Roger, Testoni, Sabrina Gloria Giulia, Mohelnikova-Duchonova, Beatrice, Lucchesi, Maurizio, Rizzato, Cosmeri, Canzian, Federico, and Campa, Daniele

Abstract

INTRODUCTION: Only a small number of risk factors for pancreatic ductal adenocarcinoma (PDAC) has been established. Several studies identified a role of epigenetics and of deregulation of DNA methylation. DNA methylation is variable across a lifetime and in different tissues; nevertheless, its levels can be regulated by genetic variants like methylation quantitative trait loci (mQTLs), which can be used as a surrogate.MATERIALS AND METHODS: We scanned the whole genome for mQTLs and performed an association study in 14 705 PDAC cases and 246 921 controls. The methylation data were obtained from whole blood and pancreatic cancer tissue through online databases. We used the Pancreatic Cancer Cohort Consortium and the Pancreatic Cancer Case-Control Consortium genome-wide association study (GWAS) data as discovery phase and the Pancreatic Disease Research consortium, the FinnGen project and the Japan Pancreatic Cancer Research consortium GWAS as replication phase.RESULTS: The C allele of 15q26.1-rs12905855 showed an association with a decreased risk of PDAC (OR=0.90, 95% CI 0.87 to 0.94, p=4.93×10 -8 in the overall meta-analysis), reaching genome-level statistical significance. 15q26.1-rs12905855 decreases the methylation of a 'C-phosphate-G' (CpG) site located in the promoter region of the RCCD1 antisense ( RCCD1-AS1) gene which, when expressed, decreases the expression of the RCC1 domain-containing ( RCCD1) gene (part of a histone demethylase complex). Thus, it is possible that the rs12905855 C-allele has a protective role in PDAC development through an increase of RCCD1 gene expression, made possible by the inactivity of RCCD1-AS1. CONCLUSION: We identified a novel PDAC risk locus which modulates cancer risk by controlling gene expression through DNA methylation.

Published
2023

27. The PANcreatic Disease ReseArch (PANDoRA) consortium:Ten years’ experience of association studies to understand the genetic architecture of pancreatic cancer

Author

Campa, Daniele, Gentiluomo, Manuel, Stein, Angelika, Aoki, Mateus Nóbrega, Oliverius, Martin, Vodičková, Ludmila, Jamroziak, Krzysztof, Theodoropoulos, George, Pasquali, Claudio, Greenhalf, William, Arcidiacono, Paolo Giorgio, Uzunoglu, Faik, Pezzilli, Raffaele, Luchini, Claudio, Puzzono, Marta, Loos, Martin, Giaccherini, Matteo, Katzke, Verena, Mambrini, Andrea, Kiudeliene, Edita, Federico, Kauffmann Emanuele, Johansen, Julia, Hussein, Tamás, Mohelnikova-Duchonova, Beatrice, van Eijck, Casper H.J., Brenner, Hermann, Farinella, Riccardo, Pérez, Juan Sainz, Lovecek, Martin, Büchler, Markus W., Hlavac, Viktor, Izbicki, Jakob R., Hackert, Thilo, Chammas, Roger, Zerbi, Alessandro, Lawlor, Rita, Felici, Alessio, Götz, Mara, Capurso, Gabriele, Ginocchi, Laura, Gazouli, Maria, Kupcinskas, Juozas, Cavestro, Giulia Martina, Vodicka, Pavel, Moz, Stefania, Neoptolemos, John P., Kunovsky, Lumir, Bojesen, Stig E., Carrara, Silvia, Gioffreda, Domenica, Morkunas, Egidijus, Abian, Olga, Bunduc, Stefania, Basso, Daniela, Boggi, Ugo, Wlodarczyk, Barbara, Szentesi, Andrea, Vanella, Giuseppe, Chen, Inna, Bijlsma, Maarten F., Kiudelis, Vytautas, Landi, Stefano, Schöttker, Ben, Corradi, Chiara, Giese, Nathalia, Kaaks, Rudolf, Peduzzi, Giulia, Hegyi, Péter, Morelli, Luca, Furbetta, Niccolò, Soucek, Pavel, Latiano, Anna, Talar-Wojnarowska, Renata, Lindgaard, Sidsel C., Dijk, Frederike, Milanetto, Anna Caterina, Tavano, Francesca, Cervena, Klara, Erőss, Bálint, Testoni, Sabrina G., Verhagen-Oldenampsen, Judith H.E., Małecka-Wojciesko, Ewa, Costello, Eithne, Salvia, Roberto, Maiello, Evaristo, Ermini, Stefano, Sperti, Cosimo, Holleczek, Bernd, Perri, Francesco, Skieceviciene, Jurgita, Archibugi, Livia, Lucchesi, Maurizio, Rizzato, Cosmeri, Canzian, Federico, Campa, Daniele, Gentiluomo, Manuel, Stein, Angelika, Aoki, Mateus Nóbrega, Oliverius, Martin, Vodičková, Ludmila, Jamroziak, Krzysztof, Theodoropoulos, George, Pasquali, Claudio, Greenhalf, William, Arcidiacono, Paolo Giorgio, Uzunoglu, Faik, Pezzilli, Raffaele, Luchini, Claudio, Puzzono, Marta, Loos, Martin, Giaccherini, Matteo, Katzke, Verena, Mambrini, Andrea, Kiudeliene, Edita, Federico, Kauffmann Emanuele, Johansen, Julia, Hussein, Tamás, Mohelnikova-Duchonova, Beatrice, van Eijck, Casper H.J., Brenner, Hermann, Farinella, Riccardo, Pérez, Juan Sainz, Lovecek, Martin, Büchler, Markus W., Hlavac, Viktor, Izbicki, Jakob R., Hackert, Thilo, Chammas, Roger, Zerbi, Alessandro, Lawlor, Rita, Felici, Alessio, Götz, Mara, Capurso, Gabriele, Ginocchi, Laura, Gazouli, Maria, Kupcinskas, Juozas, Cavestro, Giulia Martina, Vodicka, Pavel, Moz, Stefania, Neoptolemos, John P., Kunovsky, Lumir, Bojesen, Stig E., Carrara, Silvia, Gioffreda, Domenica, Morkunas, Egidijus, Abian, Olga, Bunduc, Stefania, Basso, Daniela, Boggi, Ugo, Wlodarczyk, Barbara, Szentesi, Andrea, Vanella, Giuseppe, Chen, Inna, Bijlsma, Maarten F., Kiudelis, Vytautas, Landi, Stefano, Schöttker, Ben, Corradi, Chiara, Giese, Nathalia, Kaaks, Rudolf, Peduzzi, Giulia, Hegyi, Péter, Morelli, Luca, Furbetta, Niccolò, Soucek, Pavel, Latiano, Anna, Talar-Wojnarowska, Renata, Lindgaard, Sidsel C., Dijk, Frederike, Milanetto, Anna Caterina, Tavano, Francesca, Cervena, Klara, Erőss, Bálint, Testoni, Sabrina G., Verhagen-Oldenampsen, Judith H.E., Małecka-Wojciesko, Ewa, Costello, Eithne, Salvia, Roberto, Maiello, Evaristo, Ermini, Stefano, Sperti, Cosimo, Holleczek, Bernd, Perri, Francesco, Skieceviciene, Jurgita, Archibugi, Livia, Lucchesi, Maurizio, Rizzato, Cosmeri, and Canzian, Federico

Abstract

Pancreatic cancer has an incidence that almost matches its mortality. Only a small number of risk factors and 33 susceptibility loci have been identified. so Moreover, the relative rarity of pancreatic cancer poses significant hurdles for research aimed at increasing our knowledge of the genetic mechanisms contributing to the disease. Additionally, the inability to adequately power research questions prevents small monocentric studies from being successful. Several consortia have been established to pursue a better understanding of the genetic architecture of pancreatic cancers. The Pancreatic disease research (PANDoRA) consortium is the largest in Europe. PANDoRA is spread across 12 European countries, Brazil and Japan, bringing together 29 basic and clinical research groups. In the last ten years, PANDoRA has contributed to the discovery of 25 susceptibility loci, a feat that will be instrumental in stratifying the population by risk and optimizing preventive strategies., Pancreatic cancer has an incidence that almost matches its mortality. Only a small number of risk factors and 33 susceptibility loci have been identified. so Moreover, the relative rarity of pancreatic cancer poses significant hurdles for research aimed at increasing our knowledge of the genetic mechanisms contributing to the disease. Additionally, the inability to adequately power research questions prevents small monocentric studies from being successful. Several consortia have been established to pursue a better understanding of the genetic architecture of pancreatic cancers. The Pancreatic disease research (PANDoRA) consortium is the largest in Europe. PANDoRA is spread across 12 European countries, Brazil and Japan, bringing together 29 basic and clinical research groups. In the last ten years, PANDoRA has contributed to the discovery of 25 susceptibility loci, a feat that will be instrumental in stratifying the population by risk and optimizing preventive strategies.

Published
2023

28. Polymorphic variants involved in methylation regulation: a strategy to discover risk loci for pancreatic ductal adenocarcinoma

Author

IRAS OH Epidemiology Chemical Agents, IRAS – One Health Chemical, Corradi, Chiara, Lencioni, Giulia, Gentiluomo, Manuel, Felici, Alessio, Latiano, Anna, Kiudelis, Gediminas, van Eijck, Casper H J, Marta, Katalin, Lawlor, Rita T, Tavano, Francesca, Boggi, Ugo, Dijk, Frederike, Cavestro, Giulia Martina, Vermeulen, Roel C H, Hackert, Thilo, Petrone, Maria Chiara, Uzunoğlu, Faik Güntac, Archibugi, Livia, Izbicki, Jakob R, Morelli, Luca, Zerbi, Alessandro, Landi, Stefano, Stocker, Hannah, Talar-Wojnarowska, Renata, Di Franco, Gregorio, Hegyi, Péter, Sperti, Cosimo, Carrara, Silvia, Capurso, Gabriele, Gazouli, Maria, Brenner, Hermann, Bunduc, Stefania, Busch, Olivier, Perri, Francesco, Oliverius, Martin, Hegyi, Péter Jeno, Goetz, Mara, Scognamiglio, Pasquale, Mambrini, Andrea, Arcidiacono, Paolo Giorgio, Kreivenaite, Edita, Kupcinskas, Juozas, Hussein, Tamas, Ermini, Stefano, Milanetto, Anna Caterina, Vodicka, Pavel, Kiudelis, Vytautas, Hlaváč, Viktor, Soucek, Pavel, Theodoropoulos, George E, Basso, Daniela, Neoptolemos, John P, Nóbrega Aoki, Mateus, Pezzilli, Raffaele, Pasquali, Claudio, Chammas, Roger, Testoni, Sabrina Gloria Giulia, Mohelnikova-Duchonova, Beatrice, Lucchesi, Maurizio, Rizzato, Cosmeri, Canzian, Federico, Campa, Daniele, IRAS OH Epidemiology Chemical Agents, IRAS – One Health Chemical, Corradi, Chiara, Lencioni, Giulia, Gentiluomo, Manuel, Felici, Alessio, Latiano, Anna, Kiudelis, Gediminas, van Eijck, Casper H J, Marta, Katalin, Lawlor, Rita T, Tavano, Francesca, Boggi, Ugo, Dijk, Frederike, Cavestro, Giulia Martina, Vermeulen, Roel C H, Hackert, Thilo, Petrone, Maria Chiara, Uzunoğlu, Faik Güntac, Archibugi, Livia, Izbicki, Jakob R, Morelli, Luca, Zerbi, Alessandro, Landi, Stefano, Stocker, Hannah, Talar-Wojnarowska, Renata, Di Franco, Gregorio, Hegyi, Péter, Sperti, Cosimo, Carrara, Silvia, Capurso, Gabriele, Gazouli, Maria, Brenner, Hermann, Bunduc, Stefania, Busch, Olivier, Perri, Francesco, Oliverius, Martin, Hegyi, Péter Jeno, Goetz, Mara, Scognamiglio, Pasquale, Mambrini, Andrea, Arcidiacono, Paolo Giorgio, Kreivenaite, Edita, Kupcinskas, Juozas, Hussein, Tamas, Ermini, Stefano, Milanetto, Anna Caterina, Vodicka, Pavel, Kiudelis, Vytautas, Hlaváč, Viktor, Soucek, Pavel, Theodoropoulos, George E, Basso, Daniela, Neoptolemos, John P, Nóbrega Aoki, Mateus, Pezzilli, Raffaele, Pasquali, Claudio, Chammas, Roger, Testoni, Sabrina Gloria Giulia, Mohelnikova-Duchonova, Beatrice, Lucchesi, Maurizio, Rizzato, Cosmeri, Canzian, Federico, and Campa, Daniele

Published
2023

30. NDRG4 promoter hypermethylation is a mechanistic biomarker associated with metastatic progression in breast cancer patients

Author

Jandrey, Elisa H. F., Moura, Ricardo P., Andrade, Luciana N. S., Machado, Camila L., Campesato, Luiz Felipe, Leite, Katia Ramos M., Inoue, Lilian T., Asprino, Paula F., da Silva, Ana Paula M., de Barros, Alfredo Carlos S. D., Carvalho, Andre, de Lima, Vladmir C., Carraro, Dirce M., Brentani, Helena P., da Cunha, Isabela W., Soares, Fernando A., Parmigiani, Raphael B., Chammas, Roger, Camargo, Anamaria A., and Costa, Érico T.

Published
2019
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31. Unraveling the peripheral and local role of inflammatory cytokines in glioblastoma survival

Author

Cavalheiro, Vitor J., primary, Campos, Ana Carolina P., additional, Lima, Luiz G.C.A., additional, Roça, Cairo Thomé, additional, Docema, Marcos Fernando L., additional, Lancellotti, Carmen Lucia P., additional, Martinez, Raquel C.R., additional, Pagano, Rosana L., additional, Chammas, Roger, additional, Teixeira, Manoel J., additional, Maldaun, Marcos V.C., additional, and Neville, Iuri S., additional

Published
2023
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33. Collagen V α1 Chain Decrease in Papillary Dermis from Early Systemic Sclerosis: A New Proposal in Cutaneous Fibrosis Molecular Structure

Author

de Morais, Jymenez, primary, Velosa, Ana Paula P., additional, Andrade, Priscila C., additional, Frediani, Denise, additional, Carrasco, Solange, additional, Queiroz, Zelita A. de Jesus, additional, Martin, Patrícia, additional, Saito, Renata F., additional, Elias, Vitória, additional, Goldenstein-Schainberg, Cláudia, additional, Chammas, Roger, additional, Sampaio-Barros, Percival D., additional, Capelozzi, Vera L., additional, and Teodoro, Walcy R., additional

Published
2022
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34. Melatonin Regulates the Daily Levels of Plasma Amino Acids, Acylcarnitines, Biogenic Amines, Sphingomyelins, and Hexoses in a Xenograft Model of Triple Negative Breast Cancer

Author

Junior, Rubens Paula, primary, Chuffa, Luiz Gustavo de Almeida, additional, Simão, Vinicius Augusto, additional, Sonehara, Nathália Martins, additional, Chammas, Roger, additional, Reiter, Russel J., additional, and Zuccari, Debora Aparecida Pires de Campos, additional

Published
2022
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35. Allergic sensitization and exposure to ambient air pollution beginning early in life lead to a COPD-like phenotype in young adult mice

Author

de Souza Xavier Costa, Natália, primary, Mirtes Teles, Aila, additional, de Brito, Jôse Mára, additional, de Barros Mendes Lopes, Thaís, additional, Calciolari Rossi, Renata, additional, Magalhães Arantes Costa, Fernanda, additional, Mangueira Saraiva-Romanholo, Beatriz, additional, Perini, Adenir, additional, Furuya, Tatiane Katsue, additional, Germán Murillo Carrasco, Alexis, additional, Matera Veras, Mariana, additional, Nascimento Saldiva, Paulo Hilário, additional, Chammas, Roger, additional, and Mauad, Thais, additional

Published
2022
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36. MG-Pe: A Novel Galectin-3 Ligand with Antimelanoma Properties and Adjuvant Effects to Dacarbazine

Author

Biscaia, Stellee M. P., primary, Pires, Cassiano, additional, Lívero, Francislaine A. R., additional, Bellan, Daniel L., additional, Bini, Israel, additional, Bustos, Silvina O., additional, Vasconcelos, Renata O., additional, Acco, Alexandra, additional, Iacomini, Marcello, additional, Carbonero, Elaine R., additional, Amstalden, Martin K., additional, Kubata, Fábio R., additional, Cummings, Richard D., additional, Dias-Baruffi, Marcelo, additional, Simas, Fernanda F., additional, Oliveira, Carolina C., additional, Freitas, Rilton A., additional, Franco, Célia Regina Cavichiolo, additional, Chammas, Roger, additional, and Trindade, Edvaldo S., additional

Published
2022
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37. miRNA and mRNA Expression Profiles Associated with Lymph Node Metastasis and Prognosis in Penile Carcinoma

Author

Murta, Claudio B., primary, Furuya, Tatiane K., additional, Carrasco, Alexis G. M., additional, Uno, Miyuki, additional, Sichero, Laura, additional, Villa, Luisa L., additional, Faraj, Sheila F., additional, Coelho, Rafael F., additional, Guglielmetti, Giuliano B., additional, Cordeiro, Mauricio D., additional, Leite, Katia R. M., additional, Nahas, William C., additional, Chammas, Roger, additional, and Pontes, José, additional

Published
2022
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39. Perfil bioquímico y significado clínico de los genes de la vía MAPK /CINASA en el diagnóstico de neoplasias tiroides

Author

Santos, Joyce Nascimento, Silva, Raissa Monteiro da, Bhattacharjee, Tanmoy Tapobrata, Kulcsar, Marco Aurélio Vamondes, Uno, Miyuki, Chammas, Roger, and Canevari, Renata de Azevedo

Subjects
Thyroid, MAPK/KINASE, FTIR, Tireoide, Marcador molecular, Gene expression, Molecular marker, Expressão gênica, Espectroscopia, Tiroides, Spectroscopy, La expresion genica
Abstract

Thyroid neoplasms are the main types of endocrine malignancy, their incidence increasing in recent years. Routine diagnosis may present inconclusive results, leading to the need for using additional techniques that are more precise, such as molecular analysis. Therefore, it is essential to search for molecular markers for the diagnosis of these malignancies and their different histological types. The objective of this study was to identify diagnostic molecular markers for papillary thyroid carcinomas (PTC) and goiter lesions. For this, expression of genes belonging to the MAPK/KINASE pathway was assessed by the RT-qPCR technique. Additionally, complete biochemical profiles of the samples were obtained using Fourier transform infrared spectroscopy (FTIR). Results of RT-qPCR suggest that FOS, JUN, MAP2K6, CCNA1, SFN genes have the potential to be tumor markers of thyroid lesions, and the MAP2K6, CCNA1, SFN genes further have the potential to distinguish PTC samples from other thyroid lesions. FTIR results showed that PTC lesions can be distinguished from normal and benign tissues with 95.83% efficiency; changes in nucleic acids being the major classifying factor. Overall, results suggest potential of molecular and FTIR analysis in diagnosis of thyroid cancer. Las neoplasias tiroideas son los principales tipos de malignidad endocrina, incrementándose su incidencia en los últimos años. El diagnóstico de rutina puede presentar resultados no concluyentes, lo que obliga a utilizar técnicas adicionales más precisas, como el análisis molecular. Por lo tanto, es fundamental la búsqueda de marcadores moleculares para el diagnóstico de estas neoplasias malignas y sus diferentes tipos histológicos. El objetivo de este estudio fue identificar marcadores moleculares de diagnóstico para carcinomas papilares de tiroides (CPT) y lesiones de bocio. Para ello, se evaluó la expresión de genes pertenecientes a la vía MAPK/KINASE mediante la técnica RT-qPCR. Además, se obtuvieron perfiles bioquímicos completos de las muestras mediante espectroscopia infrarroja transformada de Fourier (FTIR). Los resultados de RT-qPCR sugieren que los genes FOS, JUN, MAP2K6, CCNA1, SFN tienen el potencial de ser marcadores tumorales de lesiones tiroideas, y los genes MAP2K6, CCNA1, SFN tienen además el potencial de distinguir muestras de CPT de otras lesiones tiroideas. Los resultados de FTIR mostraron que las lesiones de CPT se pueden distinguir de los tejidos normales y benignos con una eficiencia del 95,83 %; siendo los cambios en los ácidos nucleicos el principal factor de clasificación. En general, los resultados sugieren el potencial del análisis molecular y FTIR en el diagnóstico del cáncer de tiroides. As neoplasias da tireoide são os principais tipos de malignidade endócrina, apresentando incidência aumentada nos últimos anos. O diagnóstico de rotina pode apresentar resultados inconclusivos, levando à necessidade de utilização de técnicas adicionais mais precisas, tais como a análise molecular. Portanto, é essencial a busca de marcadores moleculares para o diagnóstico dessas neoplasias e seus diferentes tipos histológicos. O objetivo deste estudo foi identificar marcadores moleculares diagnósticos para carcinoma papilífero de tireoide (CPT) e lesões de bócio. Para isso, a expressão de genes pertencentes à via MAPK/KNASE foi avaliada pela técnica de RT-qPCR. Adicionalmente, perfis bioquímicos completos das amostras foram obtidos por meio da espectroscopia de infravermelho com transformada de Fourier (FTIR). Os resultados do RT-qPCR sugerem que os genes FOS, JUN, MAP2K6, CCNA1, SFN têm o potencial de serem marcadores tumorais de lesões da tireoide, e os genes MAP2K6, CCNA1, SFN têm ainda o potencial de distinguir amostras de CPT de outras lesões de tireoide. Os resultados do FTIR mostraram que as lesões de CPT podem ser diferenciadas de tecidos normais e benignos com 95,83% de eficiência; sendo as alterações nos ácidos nucleicos o principal fator de classificação. No geral, os resultados sugerem o potencial da análise molecular e do FTIR no diagnóstico do câncer de tireoide.

Published
2022

41. An international, interlaboratory ring trial confirms the feasibility of an extraction-less “direct” RT-qPCR method for reliable detection of SARS-CoV-2 RNA in clinical samples

Author

Mills, Margaret G., primary, Bruce, Emily, additional, Huang, Meei-Li, additional, Crothers, Jessica W., additional, Hyrien, Ollivier, additional, Oura, Christopher A. L., additional, Blake, Lemar, additional, Brown Jordan, Arianne, additional, Hester, Susan, additional, Wehmas, Leah, additional, Mari, Bernard, additional, Barby, Pascal, additional, Lacoux, Caroline, additional, Fassy, Julien, additional, Vial, Pablo, additional, Vial, Cecilia, additional, Martinez, Jose R. W., additional, Oladipo, Olusola Olalekan, additional, Inuwa, Bitrus, additional, Shittu, Ismaila, additional, Meseko, Clement A., additional, Chammas, Roger, additional, Santos, Carlos Ferreira, additional, Dionísio, Thiago José, additional, Garbieri, Thais Francini, additional, Parisi, Viviane Aparecida, additional, Mendes-Correa, Maria Cassia, additional, de Paula, Anderson V., additional, Romano, Camila M., additional, Góes, Luiz Gustavo Bentim, additional, Minoprio, Paola, additional, Campos, Angelica C., additional, Cunha, Marielton P., additional, Vilela, Ana Paula P., additional, Nyirenda, Tonney, additional, Mkakosya, Rajhab Sawasawa, additional, Muula, Adamson S., additional, Dumm, Rebekah E., additional, Harris, Rebecca M., additional, Mitchell, Constance A., additional, Pettit, Syril, additional, Botten, Jason, additional, and Jerome, Keith R., additional

Published
2022
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45. Identification of Recessively Inherited Genetic Variants Potentially Linked to Pancreatic Cancer Risk

Author

Lu, Ye, primary, Gentiluomo, Manuel, additional, Macauda, Angelica, additional, Gioffreda, Domenica, additional, Gazouli, Maria, additional, Petrone, Maria C., additional, Kelemen, Dezső, additional, Ginocchi, Laura, additional, Morelli, Luca, additional, Papiris, Konstantinos, additional, Greenhalf, William, additional, Izbicki, Jakob R., additional, Kiudelis, Vytautas, additional, Mohelníková-Duchoňová, Beatrice, additional, Bueno-de-Mesquita, Bas, additional, Vodicka, Pavel, additional, Brenner, Hermann, additional, Diener, Markus K., additional, Pezzilli, Raffaele, additional, Ivanauskas, Audrius, additional, Salvia, Roberto, additional, Szentesi, Andrea, additional, Aoki, Mateus Nóbrega, additional, Németh, Balázs C., additional, Sperti, Cosimo, additional, Jamroziak, Krzysztof, additional, Chammas, Roger, additional, Oliverius, Martin, additional, Archibugi, Livia, additional, Ermini, Stefano, additional, Novák, János, additional, Kupcinskas, Juozas, additional, Strouhal, Ondřej, additional, Souček, Pavel, additional, Cavestro, Giulia M., additional, Milanetto, Anna C., additional, Vanella, Giuseppe, additional, Neoptolemos, John P., additional, Theodoropoulos, George E., additional, van Laarhoven, Hanneke W. M., additional, Mambrini, Andrea, additional, Moz, Stefania, additional, Kala, Zdenek, additional, Loveček, Martin, additional, Basso, Daniela, additional, Uzunoglu, Faik G., additional, Hackert, Thilo, additional, Testoni, Sabrina G. G., additional, Hlaváč, Viktor, additional, Andriulli, Angelo, additional, Lucchesi, Maurizio, additional, Tavano, Francesca, additional, Carrara, Silvia, additional, Hegyi, Péter, additional, Arcidiacono, Paolo G., additional, Busch, Olivier R., additional, Lawlor, Rita T., additional, Puzzono, Marta, additional, Boggi, Ugo, additional, Guo, Feng, additional, Małecka-Panas, Ewa, additional, Capurso, Gabriele, additional, Landi, Stefano, additional, Talar-Wojnarowska, Renata, additional, Strobel, Oliver, additional, Gao, Xin, additional, Vashist, Yogesh, additional, Campa, Daniele, additional, and Canzian, Federico, additional

Published
2021
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50. Potential of [ 11 C](R)-PK11195 PET Imaging for Evaluating Tumor Inflammation: A Murine Mammary Tumor Model.

Author

de Souza, Aline Morais, Real, Caroline Cristiano, Junqueira, Mara de Souza, Estessi de Souza, Larissa, Navarro Marques, Fábio Luiz, Buchpiguel, Carlos Alberto, Chammas, Roger, Sapienza, Marcelo Tatit, and de Paula Faria, Daniele

Subjects
POSITRON emission tomography, BREAST tumors, AUTORADIOGRAPHY
Abstract

Background: Breast tumor inflammation is an immunological process that occurs mainly by mediation of Tumor-Associated Macrophages (TAM). Aiming for a specific measurement of tumor inflammation, the current study evaluated the potential of Positron Emission Tomography (PET) imaging with [11C](R)-PK11195 to evaluate tumor inflammation in a mammary tumor animal model. Methods: Female Balb/C mice were inoculated with 4T1 cells. The PET imaging with [11C](R)-PK11195 and [18F]FDG was acquired 3 days, 1 week, and 2 weeks after cell inoculation. Results: The [11C](R)-PK11195 tumor uptake increased from 3 days to 1 week, and decreased at 2 weeks after cell inoculation, as opposed to the [18F]FDG uptake, which showed a slight decrease in uptake at 1 week and increased uptake at 2 weeks. In the control group, no significant differences occurred in tracer uptake over time. Tumor uptake of both radiopharmaceuticals is more expressed in tumor edge regions, with greater intensity at 2 weeks, as demonstrated by [11C](R)-PK11195 autoradiography and immunofluorescence with TSPO antibodies and CD86 pro-inflammatory phenotype. Conclusion: The [11C](R)-PK11195 was able to identify heterogeneous tumor inflammation in a murine model of breast cancer and the uptake varied according to tumor size. Together with the glycolytic marker [18F]FDG, molecular imaging with [11C](R)-PK11195 may provide a better characterization of inflammatory responses in cancer. [ABSTRACT FROM AUTHOR]

Published
2022
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