Search

Your search keyword '"Chai, Paul J."' showing total 178 results
Start Over Author "Chai, Paul J." Search Limiters Full Text
178 results on '"Chai, Paul J."'

3. Comparison of Management Strategies for Neonates With Symptomatic Tetralogy of Fallot

Author

Goldstein, Bryan H., Petit, Christopher J., Qureshi, Athar M., McCracken, Courtney E., Kelleman, Michael S., Nicholson, George T., Law, Mark A., Meadows, Jeffery J., Zampi, Jeffrey D., Shahanavaz, Shabana, Mascio, Christopher E., Chai, Paul J., Romano, Jennifer C., Batlivala, Sarosh P., Maskatia, Shiraz A., Asztalos, Ivor B., Kamsheh, Alicia M., Healan, Steven J., Smith, Justin D., Ligon, R. Allen, Pettus, Joelle A., Juma, Sarina, Raulston, James E.B., Hock, Krissie M., Pajk, Amy L., Eilers, Lindsay F., Khan, Hala Q., Merritt, Taylor C., Canter, Matthew, Juergensen, Stephan, Rinderknecht, Fatuma-Ayaan, Bauser-Heaton, Holly, and Glatz, Andrew C.

Published
2021
Full Text
View/download PDF

5. Pulmonary Artery Hypoplasia in Neonates With Tetralogy of Fallot

Author

Petit, Christopher J., primary, Glatz, Andrew C., additional, Goldstone, Andrew B., additional, Law, Mark A., additional, Romano, Jennifer C., additional, Maskatia, Shiraz A., additional, Chai, Paul J., additional, Zampi, Jeffrey D., additional, Meadows, Jeffery J., additional, Nicholson, George T., additional, Shahanavaz, Shabana, additional, Qureshi, Athar M., additional, McCracken, Courtney E., additional, Mascio, Christopher E., additional, Batlivala, Sarosh P., additional, Asztalos, Ivor B., additional, Healan, Steven J., additional, Smith, Justin D., additional, Pettus, Joelle A., additional, Beshish, Asaad, additional, Raulston, James E.B., additional, Hock, Krissie M., additional, Pajk, Amy L., additional, and Goldstein, Bryan H., additional

Published
2023
Full Text
View/download PDF

13. Bioprosthetic Pulmonary Valve Dysfunction in Congenital Heart Disease.

Author

Patel, Parth M., Zapata, David, Qu, William, Callahan, Mia, Rao, Nikita, Kelleman, Michael, Kanter, Kirk R., Chai, Paul J., Shaw, Fawwaz R., Shashidharan, Subhadra, and Rosenblum, Joshua M.

Abstract

We aim to identify the incidence and timing of dysfunction and failure of stented bioprosthetic valves in the pulmonary position in congenital heart disease patients. A total of 482 congenital heart disease patients underwent 484 stented bioprosthetic pulmonary valve implantations between 2008 and 2018. There were 164 porcine valves (Porcine) and 320 bovine pericardial valves (Pericardial) implanted. Primary endpoints were survival, valve dysfunction, and valve failure. Pericardial valves were implanted in older patients (22.0, interquartile range [IQR] 14-33 vs 16.0, IQR 11-23 years, P < 0.001). Five-year survival (96.7% vs 97.9%) for the Pericardial and Porcine groups, respectively, were similar, P > 0.05. Forty-six (34%) Porcine and 75 (27%) Pericardial group patients met criteria for valve dysfunction at a median echocardiographic follow-up time of 7.43 years (IQR 4.1-9.5 years) and 3.26 years (IQR 1.7-4.7 years), respectively. More Pericardial group patients suffered from at least mild late PR while late median peak gradient was higher in the Porcine group, P <.001 for both. Risk factors for valve dysfunction included decreasing patient age for the entire cohort (hazard ratio [HR] 1.02, 95% confidence interval [CI] 1.00-1.04, P =.015) and lack of anticoagulation at discharge for the Porcine group (HR 3.06, 95% CI 1.03-9.10, P =.044) but not the Pericardial group. Five-year cumulative incidence of dysfunction was 39% for the Pericardial group and 17% for the Porcine group. Porcine stented and bovine pericardial stented valves can be implanted in the pulmonary position in all age groups safely. However, despite similar rates of valve failure, bovine pericardial stented valves have a higher incidence of valve dysfunction at mid-term follow-up. [ABSTRACT FROM AUTHOR]

Published
2023
Full Text
View/download PDF

15. Comparative Costs of Management Strategies for Neonates With Symptomatic Tetralogy of Fallot

Author

O’Byrne, Michael L., primary, Glatz, Andrew C., additional, Huang, Yuan-shung V., additional, Kelleman, Michael S., additional, Petit, Christopher J., additional, Qureshi, Athar M., additional, Shahanavaz, Shabana, additional, Nicholson, George T., additional, Batlivala, Shawn, additional, Meadows, Jeffery J., additional, Zampi, Jeffrey D., additional, Law, Mark A., additional, Romano, Jennifer C., additional, Mascio, Christopher E., additional, Chai, Paul J., additional, Maskatia, Shiraz, additional, Asztalos, Ivor B., additional, Beshish, Asaad, additional, Pettus, Joelle, additional, Pajk, Amy L., additional, Healan, Steven J., additional, Eilers, Lindsay F., additional, Merritt, Taylor, additional, McCracken, Courtney E., additional, and Goldstein, Bryan H., additional

Published
2022
Full Text
View/download PDF

16. INFLUENCE OF INITIAL TREATMENT STRATEGY UPON LATE STATUS AND REINTERVENTION IN NEONATES WITH SYMPTOMATIC TETRALOGY OF FALLOT

Author

Meadows, Jeffery, primary, Glatz, Andrew C., additional, Goldstein, Bryan H., additional, Petit, Christopher J., additional, McCracken, Courtney, additional, Kelleman, Mike, additional, Nicholson, George T., additional, Law, Mark Aaron, additional, Zampi, Jeffrey, additional, Shahanavaz, Shabana, additional, Mascio, Christopher E., additional, Chai, Paul J., additional, Romano, Jennifer C., additional, Batlivala, Sarosh P., additional, Maskatia, Shiraz, additional, Asztalos, Ivor, additional, Kamsheh, Alicia M., additional, Healan, Steven, additional, Smith, Justin, additional, Ligon, Allen, additional, Juergensen, Stephan, additional, and Pettus, Joelle, additional

Published
2022
Full Text
View/download PDF

17. Comparison of management strategies for neonates with symptomatic tetralogy of Fallot and weight <2.5 kg

Author

Qureshi, Athar M., primary, Caldarone, Christopher A., additional, Romano, Jennifer C., additional, Chai, Paul J., additional, Mascio, Christopher E., additional, Glatz, Andrew C., additional, Petit, Christopher J., additional, McCracken, Courtney E., additional, Kelleman, Michael S., additional, Nicholson, George T., additional, Meadows, Jeffery J., additional, Zampi, Jeff D., additional, Shahanavaz, Shabana, additional, Law, Mark A., additional, Batlivala, Sarosh P., additional, Goldstein, Bryan H., additional, Eilers, Lindsay F., additional, Khan, Hala Q., additional, Smith, Justin D., additional, Asztalos, Ivor B., additional, Kamsheh, Alicia M., additional, Pettus, Joelle, additional, Ligon, R. Allen, additional, Healan, Steven J., additional, Juergensen, Stephan, additional, Merritt, Taylor C., additional, Hock, Kristal M., additional, Raulston, Jeb, additional, Huskey, Jordan L., additional, and Pajk, Amy, additional

Published
2022
Full Text
View/download PDF

18. Bioprosthetic Pulmonary Valve Dysfunction in Congenital Heart Disease

Author

Patel, Parth M., primary, Zapata, David, additional, Qu, William, additional, Callahan, Mia, additional, Rao, Nikita, additional, Kelleman, Michael, additional, Kanter, Kirk R., additional, Chai, Paul J., additional, Shaw, Fawwaz R., additional, Shashidharan, Subhadra, additional, and Rosenblum, Joshua M., additional

Published
2022
Full Text
View/download PDF

36. The free radical spin trap [alpha]-phenyl-tert-butyl nitrone attenuates the cerebral response to deep hypothermic ischemia

Author

Langley, Stephen M., Chai, Paul J., Jaggers, James J., and Ungerleider, Ross M.

Subjects
Children -- Health aspects, Ischemia, Health
Abstract

Byline: Stephen M. Langley, Paul J. Chai, James J. Jaggers, Ross M. Ungerleider Abstract: Objective: The aim of this study was to assess the role of reactive oxygen species in the impairment of cerebral recovery that follows deep hypothermic circulatory arrest. Methods: Twelve 1-week-old piglets were randomized to placebo (control group; n = 6) or 100 mg * kg.sup.-1 intravenous [alpha]-phenyl-tert -butyl nitrone, a free radical spin trap (PBN group; n = 6). All piglets underwent cardiopulmonary bypass, cooling to 18[degrees]C, 60 minutes of circulatory arrest followed by 60 minutes of reperfusion, and rewarming. Cerebral blood flow and metabolism were determined at baseline before deep hypothermic circulatory arrest and after 60 minutes of reperfusion. Results: In control animals, mean global cerebral blood flow ([+ or -] 1 standard error) before circulatory arrest was 48.4 [+ or -] 3.6 mL * 100 g.sup.-1 * min.sup.-1 and fell to 25.1 [+ or -] 3.6 mL * 100 g.sup.-1 * min.sup.-1 after circulatory arrest (P = .001). Global cerebral metabolism fell from 3.5 [+ or -] 0.2 mL * 100 g.sup.-1 * min.sup.-1 before arrest to 2.2 [+ or -] 0.2 mL * 100 g.sup.-1 * min.sup.-1 after circulatory arrest (P = .0002). In the PBN group after circulatory arrest, the mean global cerebral blood flow and metabolism of 37.2 [+ or -] 4.9 and 3.6 [+ or -] 0.5 mL * 100 g.sup.-1 * min.sup.-1, respectively, were significantly higher than in the control group (P < .05). Recovery of cerebral blood flow in the PBN group was 78% of pre-arrest level compared with 52% in the control group (P = .002). Global cerebral metabolism after circulatory arrest was 100% of the pre-arrest value compared with 61% in the control group (P = .01). Regional recovery of cerebral metabolism in the cerebellum, brain stem, and basal ganglia was 131%, 130%, and 115%, respectively, of pre-arrest values in the PBN group compared with 85%, 78%, and 70% in the control group (P < .04). Conclusions: Reactive oxygen species contribute to the impairment of cerebral recovery that follows deep hypothermic circulatory arrest. The use of [alpha]-phenyl-tert -butyl nitrone before the arrest period attenuates the normal response to ischemia and improves recovery by affording protection from free radical-mediated damage. (J Thorac Cardiovasc Surg 2000;119:305-13) Author Affiliation: Department of Pediatric Cardiac Surgery, Duke University Medical Center, Durham, NC. Article History: Received 29 June 1999; Revised 7 September 1999; Revised 11 October 1999; Accepted 26 October 1999 Article Note: (footnote) [star] Read at the Twenty-fifth Annual Meeting of The Western Thoracic Surgical Association, Olympic Valley (Lake Tahoe), Calif, June 23-26, 1999., [star][star] Address for reprints: Stephen Langley, MD, Department of Cardiothoracic Surgery, Southampton General Hospital, Southampton, Hampshire, SO16 6YD, United Kingdom (E-mail: StephenLangley@dial.pipex.com) ., a 0022-5223/2000 $12.00 + 0 12/6/104033

Published
2000

40. Blood gas management and degree of cooling: Effects on cerebral metabolism before and after circulatory arrest

Author

Skaryak, Lynne A., Chai, Paul J., Kern, Frank H., Greeley, William J., and Ungerleider, Ross M.

Subjects
Flexible response (Strategy) -- Physiological aspects, Coronary artery bypass -- Physiological aspects, Deterrence (Strategy) -- Physiological aspects, Company business management, Health
Abstract

Byline: Lynne A. Skaryak, Paul J. Chai, Frank H. Kern, William J. Greeley, Ross M. Ungerleider Abstract: This study investigated the effects of different cooling strategies on cerebral metabolic response to circulatory arrest. In particular, it examined the impact of blood gas management and degree of cooling on cerebral metabolism before and after deep hypothermic circulatory arrest. Sixty-nine 1-week-old piglets (2 to 3 kg) were placed on cardiopulmonary bypass (37[degrees]C) at 100 ml/kg per minute. Animals were cooled to 18[degrees]or 14[degrees]C as follows: alpha-stat strategy to 18[degrees]C (n = 9) or 14[degrees]C (n = 6), pH-stat strategy to 18[degrees]C (n = 9) or 14[degrees]C (n = 7), or pH-stat strategy for 18 minutes followed by a switch to alpha-stat strategy for the last 5 minutes of cooling to 18[degrees]C (n = 12) or 14[degrees]C (n = 10). Animals underwent 60 minutes of circulatory arrest followed by rewarming with alpha-stat strategy to 36[degrees]C. Control animals were cooled with alpha-stat strategy to 18[degrees]C (n = 10) or 14[degrees]C (n = 3) and then maintained on cold cardiopulmonary bypass (100 ml/kg per minute) for 60 minutes. Three animals were excluded (see text). With the use of xenon 133 clearance methods, cerebral blood flow was measured at the following points: point I, cardiopulmonary bypass (37[degrees]C); point II, cardiopulmonary bypass before circulatory arrest or control flow (18[degrees] or 14[degrees]C); and point III, cardiopulmonary bypass after rewarming (36[degrees]C). Cerebral metabolic rate of oxygen consumption was calculated for each point. At point II, cerebral metabolism was more suppressed at 14[degrees]C compared with that at 18[degrees]C. At any given temperature (18[degrees] or 14[degrees]C), pH-stat strategy provided the greatest suppression of cerebral metabolism. In control animals, cerebral metabolic oxygen consumption at point III returned to baseline values after 60 minutes of cold bypass. Sixty minutes of circulatory arrest resulted in a significant reduction in cerebral metabolic oxygen consumption at point III compared with that at point I regardless of cooling temperature or blood gas strategy. The amount of cerebral metabolic recovery was significantly reduced in the pH-stat 14[degrees]C group compared with that in the pH-stat 18[degrees]C group at point III. The use of pH-stat strategy followed by a switch to alpha-stat at 14[degrees]C provided better cerebral metabolic recovery compared with either strategy used alone. The use of pH-stat strategy during initial cooling may provide the animal with maximal cerebral metabolic suppression. The cerebral acidosis produced with pH-stat cooling may worsen cerebral metabolic injury from circulatory arrest, but this effect is eliminated with the use of alpha-stat just before the period of circulatory arrest. (J THORAC CARDIOVASC SURG 1995;110:1649-57) Author Affiliation: Durham, N.C Article History: Received 15 September 1994; Accepted 27 February 1995 Article Note: (footnote) [star] From the Departments of Surgery, a Anesthesiology, and Pediatrics, b Duke University Medical Center, Durham, N.C., [star][star] Supported in part by The Children's Miracle Network Telethon., a Address for reprints: Ross M. Ungerleider, MD, Department of Surgery, Box 3178, Duke University Medical Center, Durham, NC 27710., aa 0022-5223/95 $5.00 + 0, acents 12/1/64508

Published
1995

47. Intervention for Recoarctation in the Single Ventricle Reconstruction Trial

Author

Hill, Kevin D., primary, Rhodes, John F., additional, Aiyagari, Ranjit, additional, Baker, G. Hamilton, additional, Bergersen, Lisa, additional, Chai, Paul J., additional, Fleming, Gregory A., additional, Fudge, J. Curt, additional, Gillespie, Matthew J., additional, Gray, Robert G., additional, Hirsch, Russel, additional, Lee, Kyong-Jin, additional, Li, Jennifer S., additional, Ohye, Richard G., additional, Oster, Matthew E., additional, Pasquali, Sara K., additional, Pelech, Andrew N., additional, Radtke, Wolfgang A.K., additional, Takao, Cheryl M., additional, Vincent, Julie A., additional, and Hornik, Christoph P., additional

Published
2013
Full Text
View/download PDF

48. Abstract 9363: Intervention for Re-coarctation in the Single Ventricle Reconstruction Trial: Incidence, Risk and Outcomes

Author

Hill, Kevin D, primary, Rhodes, John F, additional, Aiyagari, Ranjit, additional, Baker, G. H, additional, Bergersen, Lisa, additional, Chai, Paul J, additional, Fleming, Gregory A, additional, Fudge, J. C, additional, Gillespie, Matthew J, additional, Gray, Robert G, additional, Hirsch, Russel, additional, Lee, Kyong-Jin, additional, Li, Jennifer S, additional, Ohye, Richard G, additional, Oster, Matthew E, additional, Pasquali, Sara K, additional, Pelech, Andrew M, additional, Radtke, Wolfgang A, additional, Takao, Cheryl M, additional, Vincent, Julie A, additional, and Hornik, Christoph P, additional

Published
2012
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results