Search

Silver ions are antimicrobial agents with powerful action against bacteria. Applications in surface treatments, as Ag + -functionalized sol-gel coatings, are expected in the biomedical field to prevent contaminations and infections. The potential cytotoxicity of Ag + cations toward human cells is well known though. However, few studies consider both the bactericidal activity and the biocompatibility of the Ag + -functionalized sol-gels. Here, we demonstrate that the cytotoxicity of Ag + cations is circumvented, thanks to the ability of Ag + cations to kill Escherichia coli ( E. coli ) much faster than normal human dermal fibroblasts (NHDFs). This phenomenon was investigated in the case of two silver nitrate-loaded sol-gel coatings: one with 0.5 w/w% Ag + cations and the second with 2.5 w/w%. The maximal amount of released Ag + ions over time (0.25 mg/L) was ten times lower than the minimal inhibition (MIC) and minimal bactericidal (MBC) concentrations (respectively, 2.5 and 16 mg/L) for E. coli and twice lower to the minimal cytotoxic concentration (0.5 mg/L) observed in NHDFs. E. coli were killed 8-18 times, respectively, faster than NHDFs by silver-loaded sol-gel coatings. This original approach, based on the kinetic control of the biological activity of Ag + cations instead of a concentration effect, ensures the bactericidal protection while maintaining the biocompatibility of the Ag + cation-functionalized sol-gels. This opens promising applications of silver-loaded sol-gel coatings for biomedical tools in short-term or indirect contacts with the skin., Competing Interests: The authors declare no competing financial interest., (© 2024 The Authors. Published by American Chemical Society.)

The design of supramolecular networks based on organic molecules deposited on surfaces, is highly attractive for various applications. One of the remaining challenges is the expansion of monolayers to well-ordered multilayers in order to enhance the functionality and complexity of self-assemblies. In this study, we present an assessment of molecular conformation from 2D to 3D supramolecular networks adsorbed onto a HOPG surface under ambient conditions utilizing a combination of scanning probe microscopies and atomic force microscopy- infrared (AFM-IR). We have observed that the infrared (IR) spectra of the designed molecules vary from layer to layer due to the modifications in the dihedral angle between the C=O group and the neighboring phenyl ring, especially in the case of a 3D supramolecular network consisting of multiple layers of molecules., (© 2023. The Author(s).)

Polymers obtained by on-surface chemistry have emerged as a class of promising materials. Here, we propose a new strategy to obtain self-assembled 1D polymers by using photochemical [2+2] cyclo-addition or by using a mild thermal annealing. All nanostructures are fully characterized by using scanning tunneling microscopy at ambient conditions on a graphite surface. We demonstrated that nature of the stimulus strongly alters the overall quality of the resulting polymers in terms of length and number of defects. This new way is an efficient method to elaborate on-surface self-assembled 1D polymers.

On-surface metal-organic polymers have emerged as a class of promising 2D materials. Here, we propose a new strategy to obtain coordination polymers by transforming supramolecular networks into coordination polymers by surface-assisted cyclo-dehydrogenation of organic building blocks. All nanostructures are fully characterized by using scanning tunneling microscopy under ultra-high vacuum on a gold surface. We demonstrated that the balance between molecule-molecule interaction and molecule-substrate interaction can be drastically modified by a strong modification of the geometry of the molecules thanks to a thermal annealing. This new way is an efficient method to elaborate on-surface coordination polymers.

Catechols are ubiquitous substances often acting as antioxidants, thus of importance in a variety of biological processes. The Fenton and Haber-Weiss processes are thought to transform these molecules into aggressive reactive oxygen species (ROS), a source of oxidative stress and possibly inducing degenerative diseases. Here, using model conditions (ultrahigh vacuum and single crystals), we unveil another process capable of converting catechols into ROSs, namely an intramolecular redox reaction catalysed by a Cu surface. We focus on a tri-catechol, the hexahydroxytriphenylene molecule, and show that this antioxidant is thereby transformed into a semiquinone, as an intermediate product, and then into an even stronger oxidant, a quinone, as final product. We argue that the transformations occur via two intramolecular redox reactions: since the Cu surface cannot oxidise the molecules, the starting catechol and the semiquinone forms each are, at the same time, self-oxidised and self-reduced. Thanks to these reactions, the quinone and semiquinone are able to interact with the substrate by readily accepting electrons donated by the substrate. Our combined experimental surface science and ab initio analysis highlights the key role played by metal nanoparticles in the development of degenerative diseases., Competing Interests: There are no conflicts to declare., (This journal is © The Royal Society of Chemistry.)

We investigated the adsorption of 4-methoxy-4'-(3-sulfonatopropyl)stilbazolium (MSPS) on different ionic (001) crystal surfaces by means of noncontact atomic force microscopy. MSPS is a zwitterionic molecule with a strong electric dipole moment. When deposited onto the substrates at room temperature, MSPS diffuses to step edges and defect sites and forms disordered assemblies of molecules. Subsequent annealing induces two different processes: First, at high coverage, the molecules assemble into a well-organized quadratic lattice, which is perfectly aligned with the <110> directions of the substrate surface (i.e., rows of equal charges) and which produces a Moiré pattern due to coincidences with the substrate lattice constant. Second, at low coverage, we observe step edges decorated with MSPS molecules that run along the <110> direction. These polar steps most probably minimize the surface energy as they counterbalance the molecular dipole by presenting oppositely charged ions on the rearranged step edge.

The capability to accurately handle liquids in small volumes is a key point for the development of lab-on-chip devices. In this paper, we investigate an application of surface acoustic waves (SAW) for positioning micro-droplets. A SAW device based on a 2 x 2 matrix of inter-digital transducers (IDTs) has been fabricated on a (YXI)/128 degrees LiNbO3 substrate, which implies displacement and detection in two dimensions of droplets atop a flat surface. Each IDT operates at a given frequency, allowing for an easy addressing of the active channel. Furthermore, very low cross-talk effects were observed as no frequency mixing arose in our device. Continuous as well as pulsed excitations of the IDTs have been studied, yielding, respectively, continuous and step-by-step droplet displacement modes. In addition, we also have used these two excitation types to control the velocity and the position of the droplets. We also have developed a theoretical analysis of the detection mode, which has been validated by experimental assessment.