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5 results on '"Ceparano, Giusy"'

3. Prognostic Impact of the Baseline Immunologic Profile in Patients with Aggressive B Non-Hodgkin Lymphomas

Author

Ramadan, Safaa M., primary, Ceparano, Giusy, additional, Cignetti, Alessandro, additional, Sammassimo, Simona, additional, Bagnardi, Vincenzo, additional, Pagan, Eleonora, additional, Gottardi, Daniela, additional, Fiori, Stefano, additional, Passerini, Rita, additional, Radice, Tommaso, additional, Saglio, Giuseppe, additional, and Tarella, Corrado, additional

Published
2019
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4. B-ALL/NHL 2002 GMALL Protocol As First-Line Treatment in Patients with Double-Hit Lymphoma: Favorable Results in18 Consecutive Patients from Two Italian Institutions

Author

Ramadan, Safaa M., primary, Cignetti, Alessandro, additional, Sammassimo, Simona, additional, Derenzini, Enrico, additional, Ceparano, Giusy, additional, Radice, Tommaso, additional, Gigli, Federica, additional, Fiori, Stefano, additional, Tabanelli, Valentina, additional, Milani, Martina, additional, Omodeo Sale', Emanuela, additional, Gandini, Sara, additional, Gottardi, Daniela, additional, Saglio, Giuseppe, additional, Pileri, Stefano, additional, and Tarella, Corrado, additional

Published
2019
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5. Prognostic Impact of Baseline Immunologic Profile in Aggressive B-cell non-Hodgkin's Lymphomas.

Author

Ramadan, Safaa, Ceparano, Giusy, Cignetti, Alessandro, Sammassimo, Simona, Bagnardi, Vincenzo, Pagan, Eleonora, Gottardi, Daniela, Fiori, Stefano, Passerini, Rita, Radice, Tommaso, Saglio, Giuseppe, and Tarella, Corrado

Subjects
*MONOCYTE lymphocyte ratio, *LYMPHOMAS, *NON-Hodgkin's lymphoma, *IMMUNOGLOBULINS
Abstract

Host immune homeostasis as an independent prognostic indicator has been inadequately evaluated in aggressive non-Hodgkin's lymphomas (NHL). The present study addresses the prognostic significance in aggressive NHLs of the immunologic profile evaluated by pretreatment serum levels of immunoglobulins (Ig) and lymphocyte-monocyte ratio (LMR). In this series of 90 patients with aggressive lymphoma, the median level for IgG was 1,024mg/dl (range 436-2236), and for LMR was 2.2 (range 0.2-13.8). CR rate was higher with IgG levels =1,024mg/dL (91% vs 77% p=0.059). LMR = 2.2 was associated with lower 1-year PFS (73% vs. 92%, p 0.016). Patients with good/very good R-IPI showed a reduced PFS if IgG or LMR was low, while patients with poor R-IPI did better if LMR or IgG levels were high. We combined both parameters with the RIPI and produced a four-risk prognostic score showing one-year PFS of 95% (95% CI 68%-99%), 100% (95% CI 100%-100%), 73% (95% CI 52%-86%), and 59% (95% CI 31%-79%), in patients with zero, one, two and three risk factors, respectively. The results indicate for the first time the value of baseline serum Ig levels in the prognostic assessment of aggressive lymphoma. [ABSTRACT FROM AUTHOR]

Published
2021
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