6 results on '"Catarina Lindqvist"'
Search Results
2. Treatment of NAFLD with intermittent calorie restriction or low-carb high-fat diet – a randomised controlled trial
- Author
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Magnus Holmer, Catarina Lindqvist, Sven Petersson, John Moshtaghi-Svensson, Veronika Tillander, Torkel B. Brismar, Hannes Hagström, and Per Stål
- Subjects
Obesity ,Diet treatment ,Low-carb-high fat (LCHF) ,Intermittent calorie restriction ,5:2 diet ,Diseases of the digestive system. Gastroenterology ,RC799-869 - Abstract
Background & Aims: The first-line treatment for non-alcoholic fatty liver disease (NAFLD) is weight reduction. Several diets have been proposed, with various effects specifically on liver steatosis. This trial compared the effects of intermittent calorie restriction (the 5:2 diet) and a low-carb high-fat diet (LCHF) on reduction of hepatic steatosis. Methods: We conducted an open-label randomised controlled trial that included 74 patients with NAFLD randomised in a 1:1:1 ratio to 12 weeks’ treatment with either a LCHF or 5:2 diet, or general lifestyle advice from a hepatologist (standard of care; SoC). The primary outcome was reduction of hepatic steatosis as measured by magnetic resonance spectroscopy. Secondary outcomes included transient elastography, insulin resistance, blood lipids, and anthropometrics. Results: The LCHF and 5:2 diets were both superior to SoC treatment in reducing steatosis (absolute reduction: LCHF: −7.2% [95% CI = −9.3 to −5.1], 5:2: −6.1% [95% CI = −8.1 to −4.2], SoC: −3.6% [95% CI = −5.8 to −1.5]) and body weight (LCHF: −7.3 kg [95% CI = −9.6 to −5.0]; 5:2: −7.4 kg [95% CI = −8.7 to −6.0]; SoC: −2.5 kg [95% CI =−3.5 to −1.5]. There was no difference between 5:2 and LCHF (p = 0.41 for steatosis and 0.78 for weight). Liver stiffness improved in the 5:2 and SoC but not in the LCHF group. The 5:2 diet was associated with reduced LDL levels and was tolerated to a higher degree than LCHF. Conclusions: The LCHF and 5:2 diets were more effective in reducing steatosis and body weight in patients with NAFLD than SoC, suggesting dietary advice can be tailored to meet individual preferences. Lay summary: For a person with obesity who suffers from fatty liver, weight loss through diet can be an effective treatment to improve the condition of the liver. Many popular diets that are recommended for weight reduction, such as high-fat diets and diets based on intermittent fasting, have not had their effects on the liver directly evaluated. This study shows that both a low-carb high-fat and the 5:2 diet are effective in treating fatty liver caused by obesity. Clinical Trials Registration: This study is registered at Clinicaltrials.gov (NCT03118310).
- Published
- 2021
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3. Macronutrient composition and its effect on body composition changes during weight loss therapy in patients with non-alcoholic fatty liver disease: Secondary analysis of a randomized controlled trial
- Author
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Catarina Lindqvist, Magnus Holmer, Hannes Hagström, Sven Petersson, Veronika Tillander, Torkel B. Brismar, and Per Stål
- Subjects
Nutrition and Dietetics ,Endocrinology, Diabetes and Metabolism - Published
- 2023
4. Protein intake early after liver transplantation and postoperative outcome: An observational study comparing two nutritional protocols
- Author
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Catarina Lindqvist, Peter Nordstedt, Mathias Vidgren, and Greg Nowak
- Subjects
Adult ,Male ,Observational Studies as Topic ,Nutrition and Dietetics ,Enteral Nutrition ,Postoperative Complications ,Nutritional Support ,Endocrinology, Diabetes and Metabolism ,Humans ,Female ,Postoperative Period ,Middle Aged ,Liver Transplantation - Abstract
Patients undergoing liver transplantation (LT) are at risk for eating difficulties. Adequate nutritional support is important to promote enhanced recovery and to reduce postoperative complications. The aim of this study was to evaluate two nutritional protocols and their effect on total protein intake during the first 7 d after LT.Adult patients were monitored daily for energy and protein intake during the first week after LT. Patients with ≥3 d of monitoring were included in the study. Two patient groups were studied: protocol A (pA) based on enteral nutrition (EN) provided from postoperative days 1 through 4 (historical control); and protocol B (pB), which was based on high volume of EN and high-protein oral nutritional supplements (ONS). Outcome measures were hospital length of stay and grade of complications according to Clavien-Dindo within the first 3 mo after transplantation.Seventy patients were included in the study (pA n=34, pB n= 36). The median age was 59 y and 70% were men. During postoperative week 1, patients with pB had a higher daily protein intake (95 g versus 77 g, P0.01) and met a higher proportion of estimated protein requirements (80% versus 70%, P0.05). There were no differences in severe postoperative outcomes between the two groups.A nutritional protocol with a higher rate of EN and high-protein ONS resulted in a higher protein intake early after LT. However, there was no difference in severe postoperative outcomes between the two nutritional protocols.
- Published
- 2021
5. Reply to: 'Reduced steatosis and weight as a result of specific diets or the dietitian themselves'
- Author
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Per Stål, Hannes Hagström, Magnus Holmer, and Catarina Lindqvist
- Subjects
medicine.medical_specialty ,Hepatology ,business.industry ,Gastroenterology ,RC799-869 ,Diseases of the digestive system. Gastroenterology ,medicine.disease ,Internal medicine ,Internal Medicine ,medicine ,Immunology and Allergy ,Steatosis ,business ,Letter to the Editor - Published
- 2021
6. Treatment of NAFLD with intermittent calorie restriction or low-carb high-fat diet – a randomised controlled trial
- Author
-
Torkel B. Brismar, Magnus Holmer, Veronika Tillander, Per Stål, Catarina Lindqvist, John Moshtaghi-Svensson, Sven Petersson, and Hannes Hagström
- Subjects
OGTT, oral glucose tolerance test ,Blood lipids ,RC799-869 ,Gastroenterology ,EoT, end of treatment ,NNR, Nordic Nutrition Recommendations 2012 ,Waist–hip ratio ,IR, insulin resistance ,WHR, waist-to-hip ratio ,Weight loss ,Intermittent fasting ,Immunology and Allergy ,Low-carb-high fat (LCHF) ,Fatty liver ,ITT, intention-to-treat analysis ,low-CHO, low-carbohydrate diet ,Diseases of the digestive system. Gastroenterology ,Diet treatment ,5:2 diet ,CT, computed tomography ,LCHF, low-carb high-fat diet ,Intermittent calorie restriction ,CAP, controlled attenuation parameter ,medicine.symptom ,Research Article ,ICR, intermittent calorie restriction ,NAFLD, non-alcoholic fatty liver disease ,medicine.medical_specialty ,HOMA-IR, homeostatic model assessment for insulin resistance ,NASH, non-alcoholic steatohepatitis ,PP, per protocol analysis ,E%, energy percent ,Insulin resistance ,ALT, alanine aminotransferase ,Internal medicine ,Internal Medicine ,medicine ,Obesity ,ALA, α-linolenic acid ,Hepatology ,SoC, standard of care ,business.industry ,PUFAs, polyunsaturated fatty acids ,MRS, magnetic resonance spectroscopy ,T2DM, type 2 diabetes mellitus ,medicine.disease ,SFAs, saturated fatty acids ,Steatosis ,MUFA, monounsaturated fatty acids ,Transient elastography ,business - Abstract
Background & Aims The first-line treatment for non-alcoholic fatty liver disease (NAFLD) is weight reduction. Several diets have been proposed, with various effects specifically on liver steatosis. This trial compared the effects of intermittent calorie restriction (the 5:2 diet) and a low-carb high-fat diet (LCHF) on reduction of hepatic steatosis. Methods We conducted an open-label randomised controlled trial that included 74 patients with NAFLD randomised in a 1:1:1 ratio to 12 weeks’ treatment with either a LCHF or 5:2 diet, or general lifestyle advice from a hepatologist (standard of care; SoC). The primary outcome was reduction of hepatic steatosis as measured by magnetic resonance spectroscopy. Secondary outcomes included transient elastography, insulin resistance, blood lipids, and anthropometrics. Results The LCHF and 5:2 diets were both superior to SoC treatment in reducing steatosis (absolute reduction: LCHF: −7.2% [95% CI = −9.3 to −5.1], 5:2: −6.1% [95% CI = −8.1 to −4.2], SoC: −3.6% [95% CI = −5.8 to −1.5]) and body weight (LCHF: −7.3 kg [95% CI = −9.6 to −5.0]; 5:2: −7.4 kg [95% CI = −8.7 to −6.0]; SoC: −2.5 kg [95% CI =−3.5 to −1.5]. There was no difference between 5:2 and LCHF (p = 0.41 for steatosis and 0.78 for weight). Liver stiffness improved in the 5:2 and SoC but not in the LCHF group. The 5:2 diet was associated with reduced LDL levels and was tolerated to a higher degree than LCHF. Conclusions The LCHF and 5:2 diets were more effective in reducing steatosis and body weight in patients with NAFLD than SoC, suggesting dietary advice can be tailored to meet individual preferences. Lay summary For a person with obesity who suffers from fatty liver, weight loss through diet can be an effective treatment to improve the condition of the liver. Many popular diets that are recommended for weight reduction, such as high-fat diets and diets based on intermittent fasting, have not had their effects on the liver directly evaluated. This study shows that both a low-carb high-fat and the 5:2 diet are effective in treating fatty liver caused by obesity. Clinical Trials Registration This study is registered at Clinicaltrials.gov (NCT03118310)., Graphical abstract, Highlights • Weight reduction is the only generally available treatment for NAFLD today. • High-fat diets, such as the LCHF, are controversial in treating NAFLD. • The 5:2 diet has become popular and is widely used to achieve weight loss. • In this RCT, both the LCHF and 5:2 diets were highly effective in treating NAFLD. • The 5:2 diet reduced LDL and liver stiffness and was tolerated to a higher degree.
- Published
- 2021
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