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An experimental set-up is presented for the in vitro characterization of the fluid dynamics in personalized phantoms of healthy and stenosed coronary arteries. The proposed set-up was fine-tuned with the aim of obtaining a compact, flexible, low-cost test-bench for biomedical applications. Technically, velocity vector fields were measured adopting a so-called smart-PIV approach, consisting of a smartphone camera and a low-power continuous laser (30 mW). Experiments were conducted in realistic healthy and stenosed 3D-printed phantoms of left anterior descending coronary artery reconstructed from angiographic images. Time resolved image acquisition was made possible by the combination of the image acquisition frame rate of last generation commercial smartphones and the flow regimes characterizing coronary hemodynamics (velocities in the order of 10 cm/s). Different flow regimes (Reynolds numbers ranging from 20 to 200) were analyzed. The smart-PIV approach was able to provide both qualitative flow visualizations and quantitative results. A comparison between smart-PIV and conventional PIV (i.e., the gold-standard experimental technique for bioflows characterization) measurements showed a good agreement in the measured velocity vector fields for both the healthy and the stenosed coronary phantoms. Displacement errors and uncertainties, estimated by applying the particle disparity method, confirmed the soundness of the proposed smart-PIV approach, as their values fell within the same range for both smart and conventional PIV measured data (≈5% for the normalized estimated displacement error and below 1.2 pixels for displacement uncertainty). In conclusion, smart-PIV represents an easy-to-implement, low-cost methodology for obtaining an adequately robust experimental characterization of cardiovascular flows. The proposed approach, to be intended as a proof of concept, candidates to become an easy-to-handle test bench suitable for use also outside of research labs, e.g., for educational or industrial purposes, or as first-line investigation to direct and guide subsequent conventional PIV measurements., Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest., (Copyright © 2022 Caridi, Torta, Mazzi, Chiastra, Audenino, Morbiducci and Gallo.)

Hydrodynamic Cavitation (HC) is considered as a promising water-disinfection technique. Due to the enormous complexity of the physical and chemical processes at play, research on HC reactors is usually carried out following an empirical approach. Surprisingly, past experimental studies have never been designed on dimensional-analysis principles, which makes it difficult to identify the key processes controlling the problem, isolate their effects and scale up the results from laboratory to full-scale scenarios. The present paper overcomes this issue and applies the principles of dimensional analysis to identify the major non-dimensional parameters controlling disinfection efficacy in classical HC reactors, namely orifice plates. On the basis of this analysis, it presents results from a new set of experiments, which were designed to isolate mainly the effects of the so-called cavitation number (σ v ). Experimental data confirm that the disinfection efficacy of orifice plates increases with decreasing σ v . Finally, in order to discuss the significance of the results presented herein and frame the scope of future research, the present paper provides an overview of the drawbacks associated with dimensional analysis within the context of HC., (Copyright © 2019 Elsevier B.V. All rights reserved.)