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15 results on '"Campioni, Silvia"'

2. Regulation of α-synuclein by chaperones in mammalian cells

Author

Burmann, Björn M., Gerez, Juan A., Matečko-Burmann, Irena, Campioni, Silvia, Kumari, Pratibha, Ghosh, Dhiman, Mazur, Adam, Aspholm, Emelie E., Šulskis, Darius, Wawrzyniuk, Magdalena, Bock, Thomas, Schmidt, Alexander, Rüdiger, Stefan G. D., Riek, Roland, and Hiller, Sebastian

Published
2020
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5. In vivo demonstration that α-synuclein oligomers are toxic

Author

Winner, Beate, Jappelli, Roberto, Maji, Samir K., Desplats, Paula A., Boyer, Leah, Aigner, Stefan, Hetzer, Claudia, Loher, Thomas, Vilar, Marçal, Campioni, Silvia, Tzitzilonis, Christos, Soragni, Alice, Jessberger, Sebastian, Mira, Helena, Consiglio, Antonella, Pham, Emiley, Masliah, Eliezer, Gage, Fred H., and Riek, Roland

Published
2011

8. Regulation of α-synuclein by chaperones in mammalian cells

Author

Burmann, Björn M., primary, Gerez, Juan A., additional, Matečko-Burmann, Irena, additional, Campioni, Silvia, additional, Kumari, Pratibha, additional, Ghosh, Dhiman, additional, Mazur, Adam, additional, Aspholm, Emelie E., additional, Šulskis, Darius, additional, Wawrzyniuk, Magdalena, additional, Bock, Thomas, additional, Schmidt, Alexander, additional, Rüdiger, Stefan G. D., additional, Riek, Roland, additional, and Hiller, Sebastian, additional

Published
2019
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10. Preparation and Characterization of Stable α-Synuclein Lipoprotein Particles

Author

Eichmann, Cédric, primary, Campioni, Silvia, additional, Kowal, Julia, additional, Maslennikov, Innokentiy, additional, Gerez, Juan, additional, Liu, Xiaoxia, additional, Verasdonck, Joeri, additional, Nespovitaya, Nadezhda, additional, Choe, Senyon, additional, Meier, Beat H., additional, Picotti, Paola, additional, Rizo, Josep, additional, Stahlberg, Henning, additional, and Riek, Roland, additional

Published
2016
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14. Accumulation of oligomer-prone α-synuclein exacerbates synaptic and neuronal degeneration in vivo

Author

Rockenstein, Edward, Nuber, Silke, Overk, Cassia R., Ubhi, Kiren, Mante, Michael, Patrick, Christina, Adame, Anthony, Trejo-Morales, Margarita, Gerez, Juan, Picotti, Paola, Jensen, Poul H., Campioni, Silvia, Riek, Roland, Winkler, Jürgen, Gage, Fred H., Winner, Beate, Masliah, Eliezer, Rockenstein, Edward, Nuber, Silke, Overk, Cassia R., Ubhi, Kiren, Mante, Michael, Patrick, Christina, Adame, Anthony, Trejo-Morales, Margarita, Gerez, Juan, Picotti, Paola, Jensen, Poul H., Campioni, Silvia, Riek, Roland, Winkler, Jürgen, Gage, Fred H., Winner, Beate, and Masliah, Eliezer

Abstract

The toxicity of α-synuclein invivo is not well understood. Rockenstein etal. describe an α-synuclein transgenic model expressing the E57K mutant that forms stable oligomers. They show that oligomers accumulate at synapses and that the mutation interferes with synaptic vesicles and is associated with behavioural deficits and neurodegeneration

15. In vivo demonstration that alpha-synuclein oligomers are toxic.

Author

Winner B, Jappelli R, Maji SK, Desplats PA, Boyer L, Aigner S, Hetzer C, Loher T, Vilar M, Campioni S, Tzitzilonis C, Soragni A, Jessberger S, Mira H, Consiglio A, Pham E, Masliah E, Gage FH, and Riek R

Subjects
Animals, Brain metabolism, Lentivirus genetics, Rats, alpha-Synuclein genetics, alpha-Synuclein metabolism, Biopolymers toxicity, alpha-Synuclein toxicity
Abstract

The aggregation of proteins into oligomers and amyloid fibrils is characteristic of several neurodegenerative diseases, including Parkinson disease (PD). In PD, the process of aggregation of α-synuclein (α-syn) from monomers, via oligomeric intermediates, into amyloid fibrils is considered the disease-causative toxic mechanism. We developed α-syn mutants that promote oligomer or fibril formation and tested the toxicity of these mutants by using a rat lentivirus system to investigate loss of dopaminergic neurons in the substantia nigra. The most severe dopaminergic loss in the substantia nigra is observed in animals with the α-syn variants that form oligomers (i.e., E57K and E35K), whereas the α-syn variants that form fibrils very quickly are less toxic. We show that α-syn oligomers are toxic in vivo and that α-syn oligomers might interact with and potentially disrupt membranes.

Published
2011
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