1. Effects of retinoic acid and zinc on the treatment of caustic esophageal burns
- Author
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Corduk N, Koltuksuz U, Calli-Demirkan N, Rota S, Abban G, and Sarioglu-Buke A
- Subjects
Animals ,Anti-Inflammatory Agents/*administration & dosage ,Antioxidants/administration & dosage ,Burns, Chemical ,Caustics/*toxicity ,Disease Models, Animal ,Esophageal Stenosis/*chemically induced ,Esophagus/injuries ,Oxidative Stress/drug effects ,Rats ,Rats, Wistar ,Tretinoin/*administration & dosage ,Zinc Sulfate/*administration & dosage - Abstract
PURPOSE: An experimental study was carried out to investigate the efficacy of an anti-inflammatory and antiproliferative agent all-trans retinoic acid (ATRA) and an antioxidant agent zinc sulphate (ZnSO(4)) in the prevention of stricture after caustic esophageal burn in rats. METHODS: Esophageal burn was induced using 50% NaOH. Rats were divided into four groups as follows: group A (sham; n = 8), group B (control; n = 8), group C (treated with ATRA; n = 8) and group D (treated with ZnSO(4); n = 8). All rats were killed on the 28th day and esophageal tissues were evaluated for histopathologic damage score, hydroxyproline (HP) content and TGF-beta1 expression. RESULTS: Significant difference was detected in terms of histopathologic damage score between groups B and C (p = 0.002). Although mean HP levels of groups C and D were lower than group B, statistical comparison was not significant. TGF-beta1 expression in group C was significantly lower than group B. CONCLUSION: Zinc has not been found effective in the prevention of stricture formation. The results indicate that ATRA has a preventive effect in the development of fibrosis in an experimental model of caustic esophageal burns in rats.
- Published
- 2010