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26 results on '"Cabellos J"'

1. Substrate interference and strain in the second harmonic generation from MoSe$_2$ monolayers

Author

Puri, S., Patel, S., Cabellos, J. L., Rosas-Hernandez, L. E., Barraza-Lopez, S., Mendoza, B., and Nakamura, H.

Subjects
Condensed Matter - Materials Science
Abstract

Nonlinear optical materials of atomic thickness--such as non-centrosymmetric 2H transition metal dichalcogenide monolayers--have a second order nonlinear susceptibility ($\chi^{(2)}$) whose intensity can be tuned by strain. However, whether $\chi^{(2)}$ is enhanced or reduced by tensile strain is a subject of conflicting reports. Here, we grow high-quality MoSe$_2$ monolayers under controlled biaxial strain created by two different substrates, and study their linear and non-linear optical responses with a combination of experimental and theoretical approaches. A 15-fold overall enhancement in second harmonic generation (SHG) intensity is observed on MoSe$_2$ monolayers grown on SiO$_2$ when compared to its value when on a Si$_3$N$_4$ substrate. A seven-fold enhancement was ascertained to substrate interference, and a factor of two to the enhancement of $\chi^{(2)}$ arising from biaxial strain: substrate interference and strain are independent handles to engineer the SHG strength of non-centrosymmetric 2D materials.

Published
2024

2. Understanding Charge Transfer in Donor-Acceptor/Metal Systems: A Combined Theoretical and Experimental Study

Author

Cabellos, J. L., Mowbray, D. J., Goiri, E., El-Sayed, A., Floreano, L., de Oteyza, D. G., Rogero, C., Ortega, J. E., and Rubio, A.

Subjects
Condensed Matter - Materials Science
Abstract

We develop an effective potential approach for assessing the flow of charge within a two-dimensional donor-acceptor/metal network based on core-level shifts. To do so, we perform both density functional theory (DFT) calculations and x-ray photoemission spectroscopy (XPS) measurements of the core-level shifts for three different monolayers adsorbed on a Ag substrate. Specifically, we consider perfluorinated pentacene (PFP), copper phthalocyanine (CuPc) and their 1:1 mixture (PFP+CuPc) adsorbed on Ag(111)., Comment: 12 pages, 10 figures

Published
2013
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4. Hazard strategy for nanoforms and nano-enabled products to implement safe-and-sustainable-by-design [Abstract]

Author

Braakhuis, H., Cabellos, J., Auffan, M., Ayerbe, R., Boyles, M., Candalija, A., Carriere, M., Catalan, J., Cross, R., Hanlon, J., Katsumiti, A., Lahive, E., Masion, A., McLean, P., Morel, E., Rashid, S., Rodriguez-Llopis, I., Ruijter, N., Simeone, F., Soeteman-Hernández, L., Vanhauten, R., Vázquez-Campos, S., Braakhuis, H., Cabellos, J., Auffan, M., Ayerbe, R., Boyles, M., Candalija, A., Carriere, M., Catalan, J., Cross, R., Hanlon, J., Katsumiti, A., Lahive, E., Masion, A., McLean, P., Morel, E., Rashid, S., Rodriguez-Llopis, I., Ruijter, N., Simeone, F., Soeteman-Hernández, L., Vanhauten, R., and Vázquez-Campos, S.

Published
2022

6. miRNA-23b as a biomarker of culture-positive neonatal sepsis

Author

Fatmi A, Rebiahi S, Chabni N, Zerrouki H, Azzaoui H, Elhabiri Y, Benmassour S, Ibanez-Cabellos J, Smahi M, Aribi M, Garcia-Gimenez J, and Pallardo F

Abstract

BACKGROUND: Neonatal sepsis remains an important cause of morbidity and mortality. The ability to quickly and accurately diagnose neonatal sepsis based on clinical assessments and laboratory blood tests remains difficult, where haemoculture is the gold standard for detecting bacterial sepsis in blood culture. It is also very difficult to study because neonatal samples are lacking. METHODS: Forty-eight newborns suspected of sepsis admitted to the Neonatology Department of the Mother-Child Specialized Hospital of Tlemcen. From each newborn, a minimum of 1-2ml of blood was drawn by standard sterile procedures for blood culture. The miRNA-23b level in haemoculture was evaluated by RT-qPCR. RESULTS: miR-23b levels increased in premature and full-term newborns in early onset sepsis (p

Published
2020

7. Oxidative Stress, a Crossroad Between Rare Diseases and Neurodegeneration

Author

Espinos C, Galindo M, Garcia-Gimeno M, Ibanez-Cabellos J, Martinez-Rubio D, Millan J, Rodrigo R, Sanz P, Seco-Cervera M, Sevilla T, Tapia A, and Pallardo F

Subjects
Charcot-Marie-Tooth disease (CMT), Dravet syndrome, Friedreich’s ataxia, Lafora disease (LD), Unverricht–Lundborg disease (ULD), inherited retinal dystrophy (IRD), neurodegenerative disorders with brain iron accumulation (NBIA), progressive myoclonus epilepsy (PME)
Abstract

Oxidative stress is an imbalance between production and accumulation of oxygen reactive species and/or reactive nitrogen species in cells and tissues, and the capacity of detoxifying these products, using enzymatic and non-enzymatic components, such as glutathione. Oxidative stress plays roles in several pathological processes in the nervous system, such as neurotoxicity, neuroinflammation, ischemic stroke, and neurodegeneration. The concepts of oxidative stress and rare diseases were formulated in the eighties, and since then, the link between them has not stopped growing. The present review aims to expand knowledge in the pathological processes associated with oxidative stress underlying some groups of rare diseases: Friedreich's ataxia, diseases with neurodegeneration with brain iron accumulation, Charcot-Marie-Tooth as an example of rare neuromuscular disorders, inherited retinal dystrophies, progressive myoclonus epilepsies, and pediatric drug-resistant epilepsies. Despite the discrimination between cause and effect may not be easy on many occasions, all these conditions are Mendelian rare diseases that share oxidative stress as a common factor, and this may represent a potential target for therapies.

Published
2020

8. Acute depletion of telomerase components DKC1 and NOP10 induces oxidative stress and disrupts ribosomal biogenesis via NPM1 and activation of the P53 pathway

Author

Ibanez-Cabellos J, Seco-Cervera M, Picher-Latorre C, Perez-Machado G, Garcia-Gimenez J, and Pallardo F

Subjects
Ageing, Oxidative stress, Telomeropathies, p53 pathway, Ribosomopathies
Abstract

Mutations in DKC1, NOP10, and TINF2 genes, coding for proteins in telomerase and shelterin complexes, are responsible for diverse diseases known as telomeropathies and ribosomopathies, including dyskeratosis congenita (DC, ORPHA 1775). These genes contribute to the DC phenotype through mechanisms that are not completely understood. We previously demonstrated in models of DC that oxidative stress is an early and independent event that occurs prior to telomere shortening. To clarify the mechanisms that induce oxidative stress, we silenced genes DKC1, NOP10, and TINF2 with siRNA technology. With RNA array hybridisation, we found several altered pathways for each siRNA model. Afterwards, we identified common related genes. The silenced cell line with the most deregulated genes and pathways was siNOP10, followed by siDKC1, and then by siTINF2 to a lesser extent. The siDKC1 and siNOP10 models shared altered expression of genes in the p53 pathway, while siNOP10 and siTINF2 had the adherens junction pathway in common. We also observed that depletion of DKC1 and NOP10 H/ACA ribonucleoprotein produced ribosomal biogenesis impairment which, in turn, promoted p53 pathway activation. Finally, we found that those enzymes responsible for GSH synthesis were down-regulated in models of siDKC1 and siNOP10. In contrast, the silenced cells for TINF2 showed no disruption of ribosomal biogenesis or oxidative stress and did not produce p53 pathway activation. These results indicate that depletion of DKC1 and NOP10 promotes oxidative stress and disrupts ribosomal biogenesis which, in turn, activates the p53 pathway.

Published
2020

11. Quality evaluation of human and environmental toxicity studies performed with nanomaterials – the GUIDEnano approach

Author

Fernández-Cruz, M.L., Hernández-Moreno, D., Catalán, J., Cross, R.K., Stockmann-Juvala, H., Cabellos, J., Lopes, Viviana R., Matzke, M., Ferraz, N., Izquierdo, J.J., Navas, J.M., Park, M., Svendsen, C., Janer, G., Fernández-Cruz, M.L., Hernández-Moreno, D., Catalán, J., Cross, R.K., Stockmann-Juvala, H., Cabellos, J., Lopes, Viviana R., Matzke, M., Ferraz, N., Izquierdo, J.J., Navas, J.M., Park, M., Svendsen, C., and Janer, G.

Abstract

The European Union FP-7 project GUIDEnano developed a web-based guidance tool, which guides users to assess human and environmental risks of nanomaterial-enabled products throughout their life cycle. One of the aims in the GUIDEnano hazard assessment strategy is to derive safety limit values based on existing human toxicity and ecotoxicological studies. Clear criteria needed to be established to select studies that could be used for such purpose. In the present paper, we present an approach for a systematical and quantitative evaluation of the quality of environmental and human toxicity studies performed with nanomaterials. The approach builds upon previous initiatives and includes refinements to facilitate its application by users with limited toxicological expertise. It covers in vivo and in vitro human toxicity studies as well as ecotoxicological studies addressing the toxicity to all environmental compartments. A scoring system related to test design and reporting considerations was developed following the principles of the Klimisch score (K score). In addition, the approach includes a scoring system based on the physicochemical properties that have been characterized and reported for the nanomaterial, including properties characterized in the exposure medium (S score). These two scores (K and S) are combined to obtain an overall quality score (Q score) that can be used to select studies, to weight different studies, and/or to introduce uncertainty factors in the risk assessment process. During its development, the approach has been tested and refined with 137 peer-reviewed articles. The final quality assessment approach and the results of its evaluation are presented here.

Published
2018

15. Circulating miR-323-3p is a biomarker for cardiomyopathy and an indicator of phenotypic variability in Friedreich’s ataxia patients

Author

Seco-Cervera, M., primary, González-Rodríguez, D., additional, Ibáñez-Cabellos, J. S., additional, Peiró-Chova, L., additional, González-Cabo, P., additional, García-López, E., additional, Vílchez, J. J., additional, Sanz-Gallego, I., additional, Pallardó, F. V., additional, and García-Giménez, J. L., additional

Published
2017
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16. Towards a nanospecific approach for risk assessment

Author

Dekkers, S., Oomen, A.G., Bleeker, E.A.J., Vandebriel, R.J., Micheletti, C., Cabellos, J., Janer, G., Fuentes, N., Vázquez-Campos, S., Borges, T., Silva, M.J., Prina-Mello, A., Movia, D., Nesslany, F., Ribeiro, A.R., Leite, P.E., Groenewold, M., Cassee, F.R., Sips, A.J.A.M., Dijkzeul, A., van Teunenbroek, T., Wijnhoven, S.W.P., Dekkers, S., Oomen, A.G., Bleeker, E.A.J., Vandebriel, R.J., Micheletti, C., Cabellos, J., Janer, G., Fuentes, N., Vázquez-Campos, S., Borges, T., Silva, M.J., Prina-Mello, A., Movia, D., Nesslany, F., Ribeiro, A.R., Leite, P.E., Groenewold, M., Cassee, F.R., Sips, A.J.A.M., Dijkzeul, A., van Teunenbroek, T., and Wijnhoven, S.W.P.

Abstract

In the current paper, a new strategy for risk assessment of nanomaterials is described, which builds upon previous project outcomes and is developed within the FP7 NANoREG project. NANoREG has the aim to develop, for the long term, new testing strategies adapted to a high number of nanomaterials where many factors can affect their environmental and health impact. In the proposed risk assessment strategy, approaches for (Quantitative) Structure Activity Relationships ((Q)SARs), grouping and read-across are integrated and expanded to guide the user how to prioritise those nanomaterial applications that may lead to high risks for human health. Furthermore, those aspects of exposure, kinetics and hazard assessment that are most likely to be influenced by the nanospecific properties of the material under assessment are identified. These aspects are summarised in six elements, which play a key role in the strategy: exposure potential, dissolution, nanomaterial transformation, accumulation, genotoxicity and immunotoxicity. With the current approach it is possible to identify those situations where the use of nanospecific grouping, read-across and (Q)SAR tools is likely to become feasible in the future, and to point towards the generation of the type of data that is needed for scientific justification, which may lead to regulatory acceptance of nanospecific applications of these tools. © 2016 The Authors

Published
2016

17. Towards a nanospecific approach for risk assessment

Author

dIRAS RA-2, LS IRAS EEPI Inhalatie Toxicologie, Dekkers, S., Oomen, A.G., Bleeker, E.A.J., Vandebriel, R.J., Micheletti, C., Cabellos, J., Janer, G., Fuentes, N., Vázquez-Campos, S., Borges, T., Silva, M.J., Prina-Mello, A., Movia, D., Nesslany, F., Ribeiro, A.R., Leite, P.E., Groenewold, M., Cassee, F.R., Sips, A.J.A.M., Dijkzeul, A., van Teunenbroek, T., Wijnhoven, S.W.P., dIRAS RA-2, LS IRAS EEPI Inhalatie Toxicologie, Dekkers, S., Oomen, A.G., Bleeker, E.A.J., Vandebriel, R.J., Micheletti, C., Cabellos, J., Janer, G., Fuentes, N., Vázquez-Campos, S., Borges, T., Silva, M.J., Prina-Mello, A., Movia, D., Nesslany, F., Ribeiro, A.R., Leite, P.E., Groenewold, M., Cassee, F.R., Sips, A.J.A.M., Dijkzeul, A., van Teunenbroek, T., and Wijnhoven, S.W.P.

Published
2016

18. Improvement of Malvar Wine quality by use of locally-selected Saccharomyces cerevisiae strains

Author

Universitat Rovira i Virgili, Cordero-Bueso G, Esteve-Zarzoso B, Gil-Díaz M, García M, Cabellos J, Arroyo T, Universitat Rovira i Virgili, and Cordero-Bueso G, Esteve-Zarzoso B, Gil-Díaz M, García M, Cabellos J, Arroyo T

Abstract

© 2016 by the authors; licensee MDPI, Basel, Switzerland. Malvar grape juice offers relatively little in the way of a sensory experience. Our interest lies in the use of locally-selected yeast strains in experimental fermentations to improve the sensory characteristics of Malvar wines. Two locally-selected strains of Saccharomyces cerevisiae were used as starter cultures in vinifications and compared with spontaneous fermentations of the same cultivar musts. Wine quality was investigated by their principal oenological parameters, analysis of the volatile aroma components, and corroborated by an experienced taster panel. The most salient chemical attributes were its high concentrations of isoamyl acetate and hexyl acetate and the high acidity, which have been detected to be key constituents in setting the fruity and fresh character of Malvar wines. Winemakers of winegrowing areas where this grape variety is cultivated will have improved options to elaborate new white wines styles, using selected yeast strains that enhance its aromatic properties.

Published
2016

19. Uracosinus: una causa poco frecuente de onfalitis recurrente en adultos

Author

Ochando Cerdán, F., Vega Menéndez, D., Pacheco Martínez, P., Ramos Fernández, M., Blanco Cabellos, J. A., Hernández Granados, P., Loinaz Segurola, C., and Quintans Rodríguez, A.

Subjects
Malformaciones del uraco, Urachal anomaly, Onfalitis recurrente, Umbilical discharge, Urachal sinus, Uracosinus
Abstract

El uracosinus es una anomalía congénita poco frecuente secundaria a la obliteración incompleta del uraco en su porción infraumbilical, que puede aparecer a cualquier edad. Presentamos un paciente de 47 años que acudió al servicio de urgencias por supuración umbilical persistente que no había respondido al tratamiento médico (antibioterapia y curas). El TAC confirmó la existencia de un sinus del uraco con cambios de onfalitis. La cirugía consistió en la resección en bloque del mismo con onfalectomía. El postoperatorio transcurrió sin incidencias. Urachal sinus is a rare congenital anomaly due to incomplete closure the urachus in the umbilical region, it is very rare in adults. 47-year-old male who arrived at our Emergency Department with recurrent umbilical discharge. Not response medical treatment (oral antibiotic and drainage). Abdominal computerized tomography scan confirmed the urachal sinus with omphalitis. Surgical complete excision with omphalectomy was performed. Any complications in the postoperative was observed.

Published
2006

22. An integrated new approach methodology for inhalation risk assessment of safe and sustainable by design nanomaterials.

Author

Motta G, Gualtieri M, Bengalli R, Saibene M, Belosi F, Nicosia A, Cabellos J, and Mantecca P

Subjects
Humans, Lung, Epithelial Cells, Risk Assessment, Inhalation Exposure analysis, Nanostructures
Abstract

The production and use of nanomaterials (NMs) has increased over the last decades posing relevant questions on their risk after release and exposure of the population or sub-populations. In this context, the safe and sustainable by design (SSbD) approach framework requires to assess the potential hazard connected with intrinsic properties of the material along the whole life cycle of the NM and/or of the nano enabled products. Moreover, in the last years, the use of new advanced methodologies (NAMs) has increasingly gained attention for the use of alternative methods in obtaining relevant information on NMs hazard and risk. Considering the SSbD and the NAMs frameworks, within the ASINA H2020 project, we developed new NAMs devoted at improving the hazard and risk definition of different Ag and TiO2 NPs. The NAMs are developed considering two air liquid interface exposure systems, the Vitrocell Cloud-α and the Cultex Compact module and the relevant steps to obtain reproducible exposures are described. The new NAMs build on the integration of environmental monitoring campaigns at nano-coating production sites, allowing the quantification by the multiple-path particle dosimetry (MPPD) model of the expected lung deposited dose in occupational settings. Starting from this information, laboratory exposures to the aerosolized NPs are performed by using air liquid interface exposure equipment and human alveolar cells (epithelial cells and macrophages), replicating the doses of exposure estimated in workers by MPPD. Preliminary results on cell viability and inflammatory responses are reported. The proposed NAMs may represent possible future reference procedures for assessing the NPs inhalation toxicology, supporting risk assessment at real exposure doses., Competing Interests: Declaration of Competing Interest The authors declare the following financial interests/personal relationships which may be considered as potential competing interests: All authors reports financial support was provided by European CommissionASINA (Anticipating Safety Issues at the Design Stage of Nano Product Development)European Project (H2020-GA 862444). All authors reports a relationship with European Commission ASINA (Anticipating Safety Issues at the Design Stage of Nano Product Development)) European Project (H2020-GA 862444) that includes: funding grants. If there are other authors, they declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper., (Copyright © 2024 The Authors. Published by Elsevier Ltd.. All rights reserved.)

Published
2024
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23. The State of the Art and Challenges of In Vitro Methods for Human Hazard Assessment of Nanomaterials in the Context of Safe-by-Design.

Author

Ruijter N, Soeteman-Hernández LG, Carrière M, Boyles M, McLean P, Catalán J, Katsumiti A, Cabellos J, Delpivo C, Sánchez Jiménez A, Candalija A, Rodríguez-Llopis I, Vázquez-Campos S, Cassee FR, and Braakhuis H

Abstract

The Safe-by-Design (SbD) concept aims to facilitate the development of safer materials/products, safer production, and safer use and end-of-life by performing timely SbD interventions to reduce hazard, exposure, or both. Early hazard screening is a crucial first step in this process. In this review, for the first time, commonly used in vitro assays are evaluated for their suitability for SbD hazard testing of nanomaterials (NMs). The goal of SbD hazard testing is identifying hazard warnings in the early stages of innovation. For this purpose, assays should be simple, cost-effective, predictive, robust, and compatible. For several toxicological endpoints, there are indications that commonly used in vitro assays are able to predict hazard warnings. In addition to the evaluation of assays, this review provides insights into the effects of the choice of cell type, exposure and dispersion protocol, and the (in)accurate determination of dose delivered to cells on predictivity. Furthermore, compatibility of assays with challenging advanced materials and NMs released from nano-enabled products (NEPs) during the lifecycle is assessed, as these aspects are crucial for SbD hazard testing. To conclude, hazard screening of NMs is complex and joint efforts between innovators, scientists, and regulators are needed to further improve SbD hazard testing.

Published
2023
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24. Higher Loading of Gold Nanoparticles in PAD Mesenchymal-like Stromal Cells Leads to a Decreased Exocytosis.

Author

Oberländer J, Ayerbe R, Cabellos J, da Costa Marques R, Li B, Günday-Türeli N, Türeli AE, Ofir R, Shalom EI, and Mailänder V

Subjects
Exocytosis, Gold, Stromal Cells, Mesenchymal Stem Cells metabolism, Metal Nanoparticles
Abstract

Cell therapy is an important new method in medicine and is being used for the treatment of an increasing number of diseases. The challenge here is the precise tracking of cells in the body and their visualization. One method to visualize cells more easily with current methods is their labeling with nanoparticles before injection. However, for a safe and sufficient cell labeling, the nanoparticles need to remain in the cell and not be exocytosed. Here, we test a glucose-PEG-coated gold nanoparticle for the use of such a cell labeling. To this end, we investigated the nanoparticle exocytosis behavior from PLX-PAD cells, a cell type currently in clinical trials as a potential therapeutic agent. We showed that the amount of exocytosed gold from the cells was influenced by the uptake time and loading amount. This observation will facilitate the safe labeling of cells with nanoparticles in the future and contribute to stem cell therapy research.

Published
2022
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25. Quantifying Emission Factors and Setting Conditions of Use According to ECHA Chapter R.14 for a Spray Process Designed for Nanocoatings-A Case Study.

Author

Koivisto AJ, Del Secco B, Trabucco S, Nicosia A, Ravegnani F, Altin M, Cabellos J, Furxhi I, Blosi M, Costa A, Lopez de Ipiña J, and Belosi F

Abstract

Spray coatings' emissions impact to the environmental and occupational exposure were studied in a pilot-plant. Concentrations were measured inside the spray chamber and at the work room in Near-Field (NF) and Far-Field (FF) and mass flows were analyzed using a mechanistic model. The coating was performed in a ventilated chamber by spraying titanium dioxide doped with nitrogen (TiO 2 N) and silver capped by hydroxyethylcellulose (Ag-HEC) nanoparticles (NPs). Process emission rates to workplace, air, and outdoor air were characterized according to process parameters, which were used to assess emission factors. Full-scale production exposure potential was estimated under reasonable worst-case (RWC) conditions. The measured TiO 2 -N and Ag-HEC concentrations were 40.9 TiO 2 -μg/m 3 and 0.4 Ag-μg/m 3 at NF (total fraction). Under simulated RWC conditions with precautionary emission rate estimates, the worker's 95th percentile 8-h exposure was ≤171 TiO 2 and ≤1.9 Ag-μg/m 3 (total fraction). Environmental emissions via local ventilation (LEV) exhaust were ca. 35 and 140 mg-NP/g-NP, for TiO 2 -N and Ag-HEC, respectively. Under current situation, the exposure was adequately controlled. However, under full scale production with continuous process workers exposure should be evaluated with personal sampling if recommended occupational exposure levels for nanosized TiO 2 and Ag are followed for risk management.

Published
2022
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26. [Urachal sinus: an unusual cause of recurrent umbilical discharge in adults].

Author

Ochando Cerdán F, Vega Menéndez D, Pacheco Martínez P, Ramos Fernández M, Blanco Cabellos JA, Hernández Granados P, Loinaz Segurola C, and Quintans Rodríguez A

Subjects
Humans, Male, Middle Aged, Tomography, X-Ray Computed, Urachus diagnostic imaging, Urachus surgery, Urologic Surgical Procedures methods, Urachus abnormalities
Abstract

Urachal sinus is a rare congenital anomaly due to incomplete closure the urachus in the umbilical region, it is very rare in adults. 47-year-old male who arrived at our Emergency Department with recurrent umbilical discharge. Not response medical treatment (oral antibiotic and drainage). Abdominal computerized tomography scan confirmed the urachal sinus with omphalitis. Surgical complete excision with omphalectomy was performed. Any complications in the postoperative was observed.

Published
2006
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