1. Proliferative retinopathy and maculopathy are two independent conditions in sickle cell disease: Is there a role of blood rheology?1
- Author
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Laurence Beral, Nathalie Lemonne, Marc Romana, Maryse Etienne-Julan, Elie Nader, Keyne Charlot, Malik Acomat, Coralie Zorobabel, Marie Billaud, Thierry David, Philippe Connes, Unité Transversale de la Drépanocytose, CHU Pointe-à-Pitre/Abymes [Guadeloupe] -Hôpital Ricou, Protéines de la membrane érythrocytaire et homologues non-érythroides, Université des Antilles et de la Guyane (UAG)-Institut National de la Transfusion Sanguine [Paris] (INTS)-Université Paris Diderot - Paris 7 (UPD7)-Université de La Réunion (UR)-Institut National de la Santé et de la Recherche Médicale (INSERM), Adaptation, Climat Tropical, Exercice et Santé (ACTES), Université des Antilles (UA), Centre de recherche Cardio-Thoracique de Bordeaux [Bordeaux] (CRCTB), Université Bordeaux Segalen - Bordeaux 2-CHU Bordeaux [Bordeaux]-Institut National de la Santé et de la Recherche Médicale (INSERM), Laboratoire Interuniversitaire de Biologie de la Motricité (LIBM ), Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Université Jean Monnet [Saint-Étienne] (UJM)-Université Savoie Mont Blanc (USMB [Université de Savoie] [Université de Chambéry]), Pharmacogénétique et abords thérapeutiques des maladies héréditaires, Université des Antilles et de la Guyane (UAG)-Université Paris Diderot - Paris 7 (UPD7)-IFR2-Institut National de la Santé et de la Recherche Médicale (INSERM), CMP La Maisonnée, Hôpital Ricou-CHU Pointe-à-Pitre/Abymes [Guadeloupe], Service d'ophtalmologie, and CHU Pointe-à-Pitre/Abymes [Guadeloupe]
- Subjects
Adult ,Male ,medicine.medical_specialty ,Physiology ,Blood viscosity ,Anemia, Sickle Cell ,030204 cardiovascular system & hematology ,Hematocrit ,Gastroenterology ,030218 nuclear medicine & medical imaging ,maculopathy ,Macular Degeneration ,03 medical and health sciences ,0302 clinical medicine ,Retinal Diseases ,Physiology (medical) ,Internal medicine ,Genotype ,retinopathy ,medicine ,Humans ,[SDV.BBM]Life Sciences [q-bio]/Biochemistry, Molecular Biology ,hemorheology ,ComputingMilieux_MISCELLANEOUS ,Hematology ,medicine.diagnostic_test ,business.industry ,[SDV.MHEP.HEM]Life Sciences [q-bio]/Human health and pathology/Hematology ,Blood Viscosity ,medicine.disease ,Sickle cell anemia ,3. Good health ,Maculopathy ,Female ,Hemorheology ,sickle cell disease ,Rheology ,Cardiology and Cardiovascular Medicine ,business ,Retinopathy - Abstract
OBJECTIVE Our study investigated the prevalence of retinopathy and maculopathy in sickle cell patients and tested the association between these two conditions. In addition, we tested whether hematological and hemorheological parameters, as well as genotype, were involved in the development of these two conditions. METHODS Seventy sickle cell adult patients were recruited: 37 with sickle cell anemia (SCA) and 33 with sickle cell hemoglobin C disease (SCC). All patients underwent retinal examination and macular ocular coherence tomography. Blood was sampled for the measurements of hematological and hemorheological parameters. RESULTS Twenty-six patients had maculopathy and 30 had retinopathy with no significant difference between SCA and SCC patients. No association between the presence of retinopathy and maculopathy was detected. RBC aggregation was higher and RBC deformability lower at 3 Pa in SCA patients. Blood viscosity and hematocrit were higher in SCC than in SCA patients. However, no association was found between biological parameters and the ocular complications studied. CONCLUSIONS Our study showed that retinopathy and maculopathy are common in sickle cell disease. Nevertheless, we found no association with hematological parameters, blood rheology or genotype.
- Published
- 2018
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