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1. Risk of hematological malignancies from CT radiation exposure in children, adolescents and young adults

Author

Bosch de Basea Gomez, Magda, Thierry-Chef, Isabelle, Harbron, Richard, Hauptmann, Michael, Byrnes, Graham, Bernier, Maria-Odile, Le Cornet, Lucian, Dabin, Jérémie, Ferro, Gilles, Istad, Tore S., Jahnen, Andreas, Lee, Choonsik, Maccia, Carlo, Malchair, Françoise, Olerud, Hilde, Simon, Steven L., Figuerola, Jordi, Peiro, Anna, Engels, Hilde, Johansen, Christoffer, Blettner, Maria, Kaijser, Magnus, Kjaerheim, Kristina, Berrington de Gonzalez, Amy, Journy, Neige, Meulepas, Johanna M., Moissonnier, Monika, Nordenskjold, Arvid, Pokora, Roman, Ronckers, Cecile, Schüz, Joachim, Kesminiene, Ausrele, and Cardis, Elisabeth

Published
2023
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2. Integrative genomic profiling of large-cell neuroendocrine carcinomas reveals distinct subtypes of high-grade neuroendocrine lung tumors.

Author

George, Julie, Walter, Vonn, Peifer, Martin, Alexandrov, Ludmil B, Seidel, Danila, Leenders, Frauke, Maas, Lukas, Müller, Christian, Dahmen, Ilona, Delhomme, Tiffany M, Ardin, Maude, Leblay, Noemie, Byrnes, Graham, Sun, Ruping, De Reynies, Aurélien, McLeer-Florin, Anne, Bosco, Graziella, Malchers, Florian, Menon, Roopika, Altmüller, Janine, Becker, Christian, Nürnberg, Peter, Achter, Viktor, Lang, Ulrich, Schneider, Peter M, Bogus, Magdalena, Soloway, Matthew G, Wilkerson, Matthew D, Cun, Yupeng, McKay, James D, Moro-Sibilot, Denis, Brambilla, Christian G, Lantuejoul, Sylvie, Lemaitre, Nicolas, Soltermann, Alex, Weder, Walter, Tischler, Verena, Brustugun, Odd Terje, Lund-Iversen, Marius, Helland, Åslaug, Solberg, Steinar, Ansén, Sascha, Wright, Gavin, Solomon, Benjamin, Roz, Luca, Pastorino, Ugo, Petersen, Iver, Clement, Joachim H, Sänger, Jörg, Wolf, Jürgen, Vingron, Martin, Zander, Thomas, Perner, Sven, Travis, William D, Haas, Stefan A, Olivier, Magali, Foll, Matthieu, Büttner, Reinhard, Hayes, David Neil, Brambilla, Elisabeth, Fernandez-Cuesta, Lynnette, and Thomas, Roman K

Subjects
Humans, Neuroendocrine Tumors, Carcinoma, Neuroendocrine, Carcinoma, Non-Small-Cell Lung, Lung Neoplasms, Immunohistochemistry, In Situ Hybridization, Fluorescence, DNA Mutational Analysis, Genomics, Small Cell Lung Carcinoma, High-Throughput Nucleotide Sequencing, In Vitro Techniques, Carcinoma, Neuroendocrine, Non-Small-Cell Lung, In Situ Hybridization, Fluorescence
Abstract

Pulmonary large-cell neuroendocrine carcinomas (LCNECs) have similarities with other lung cancers, but their precise relationship has remained unclear. Here we perform a comprehensive genomic (n = 60) and transcriptomic (n = 69) analysis of 75 LCNECs and identify two molecular subgroups: "type I LCNECs" with bi-allelic TP53 and STK11/KEAP1 alterations (37%), and "type II LCNECs" enriched for bi-allelic inactivation of TP53 and RB1 (42%). Despite sharing genomic alterations with adenocarcinomas and squamous cell carcinomas, no transcriptional relationship was found; instead LCNECs form distinct transcriptional subgroups with closest similarity to SCLC. While type I LCNECs and SCLCs exhibit a neuroendocrine profile with ASCL1high/DLL3high/NOTCHlow, type II LCNECs bear TP53 and RB1 alterations and differ from most SCLC tumors with reduced neuroendocrine markers, a pattern of ASCL1low/DLL3low/NOTCHhigh, and an upregulation of immune-related pathways. In conclusion, LCNECs comprise two molecularly defined subgroups, and distinguishing them from SCLC may allow stratified targeted treatment of high-grade neuroendocrine lung tumors.

Published
2018

3. Circulating tumour-derived KRAS mutations in pancreatic cancer cases are predominantly carried by very short fragments of cell-free DNA

Author

Zvereva, Maria, Roberti, Gabriel, Durand, Geoffroy, Voegele, Catherine, Nguyen, Minh Dao, Delhomme, Tiffany M., Chopard, Priscilia, Fabianova, Eleonora, Adamcakova, Zora, Holcatova, Ivana, Foretova, Lenka, Janout, Vladimir, Brennan, Paul, Foll, Matthieu, Byrnes, Graham B., McKay, James D., Scelo, Ghislaine, and Le Calvez-Kelm, Florence

Published
2020
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4. Main nutrient patterns are associated with prospective weight change in adults from 10 European countries

Author

Freisling, Heinz, Pisa, Pedro T, Ferrari, Pietro, Byrnes, Graham, Moskal, Aurelie, Dahm, Christina C, Vergnaud, Anne-Claire, Boutron-Ruault, Marie-Christine, Fagherazzi, Guy, Cadeau, Claire, Kühn, Tilman, Neamat-Allah, Jasmine, Buijsse, Brian, Boeing, Heiner, Halkjær, Jytte, Tjonneland, Anne, Hansen, Camilla P, Quirós, J Ramón, Travier, Noémie, Molina-Montes, Esther, Amiano, Pilar, Huerta, José M, Barricarte, Aurelio, Khaw, Kay-Tee, Wareham, Nicholas, Key, Tim J, Romaguera, Dora, Lu, Yunxia, Lassale, Camille M, Naska, Androniki, Orfanos, Philippos, Trichopoulou, Antonia, Masala, Giovanna, Pala, Valeria, Berrino, Franco, Tumino, Rosario, Ricceri, Fulvio, de Magistris, Maria Santucci, Bueno-de-Mesquita, H Bas, Ocké, Marga C, Sonestedt, Emily, Ericson, Ulrika, Johansson, Mattias, Skeie, Guri, Weiderpass, Elisabete, Braaten, Tonje, Peeters, Petra HM, and Slimani, Nadia

Subjects
Public Health, Biomedical and Clinical Sciences, Nutrition and Dietetics, Health Sciences, Clinical Research, Prevention, Nutrition, Metabolic and endocrine, Adult, Aged, Ascorbic Acid, Calcium, Dietary, Diet, Dietary Fiber, Dietary Proteins, Europe, Female, Folic Acid, Follow-Up Studies, Humans, Linear Models, Male, Middle Aged, Nutrition Assessment, Phosphorus, Dietary, Prospective Studies, Riboflavin, Surveys and Questionnaires, Weight Gain, beta Carotene, Dietary patterns, Energy balance, Nutrients, Obesity, Public health, Weight gain, Nutrition & Dietetics, Nutrition and dietetics, Epidemiology
Abstract

PurposeVarious food patterns have been associated with weight change in adults, but it is unknown which combinations of nutrients may account for such observations. We investigated associations between main nutrient patterns and prospective weight change in adults.MethodsThis study includes 235,880 participants, 25-70 years old, recruited between 1992 and 2000 in 10 European countries. Intakes of 23 nutrients were estimated from country-specific validated dietary questionnaires using the harmonized EPIC Nutrient DataBase. Four nutrient patterns, explaining 67 % of the total variance of nutrient intakes, were previously identified from principal component analysis. Body weight was measured at recruitment and self-reported 5 years later. The relationship between nutrient patterns and annual weight change was examined separately for men and women using linear mixed models with random effect according to center controlling for confounders.ResultsMean weight gain was 460 g/year (SD 950) and 420 g/year (SD 940) for men and women, respectively. The annual differences in weight gain per one SD increase in the pattern scores were as follows: principal component (PC) 1, characterized by nutrients from plant food sources, was inversely associated with weight gain in men (-22 g/year; 95 % CI -33 to -10) and women (-18 g/year; 95 % CI -26 to -11). In contrast, PC4, characterized by protein, vitamin B2, phosphorus, and calcium, was associated with a weight gain of +41 g/year (95 % CI +2 to +80) and +88 g/year (95 % CI +36 to +140) in men and women, respectively. Associations with PC2, a pattern driven by many micro-nutrients, and with PC3, a pattern driven by vitamin D, were less consistent and/or non-significant.ConclusionsWe identified two main nutrient patterns that are associated with moderate but significant long-term differences in weight gain in adults.

Published
2016

5. The time-evolution of DCIS size distributions with applications to breast cancer growth and progression

Author

Dowty, James G., Byrnes, Graham B., and Gertig, Dorota M.

Subjects
Quantitative Biology - Populations and Evolution, Quantitative Biology - Quantitative Methods, Quantitative Biology - Tissues and Organs
Abstract

Ductal carcinoma {\em in situ} (DCIS) lesions are non-invasive tumours of the breast which are thought to precede most invasive breast cancers (IBC). As individual DCIS lesions are initiated, grow and invade (i.e. become IBC) the size distribution of the DCIS lesions present in a given human population will evolve. We derive a differential equation governing this evolution and show, for given assumptions about growth and invasion, that there is a unique distribution which does not vary with time. Further, we show that any initial distribution converges to this stationary distribution exponentially quickly. It is therefore reasonable to assume that the stationary distribution is equal to the true DCIS size distribution, at least for human populations which are relatively stable with respect to the determinants of breast cancer. Based on this assumption and the size data of 110 DCIS lesions detected in a mammographic screening program between 1993 and 2000, we produce maximum likelihood estimates for certain growth and invasion parameters. Assuming that DCIS size is proportional to a positive power $p$ of the time since tumour initiation we estimate $p$ to be 0.50 with a 95% confidence interval of $(0.35, 0.71)$. Therefore we estimate that DCIS lesions follow a square-root growth law and hence that they grow rapidly when small and relatively slowly when large. Our approach and results should be useful for other mathematical studies of cancer, especially those investigating biological mechanisms of invasion., Comment: 12 pages, 2 figures and 1 table. To appear in Mathematical Medicine and Biology

Published
2013
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6. Urinary TERT promoter mutations as non-invasive biomarkers for the comprehensive detection of urothelial cancer

Author

Avogbe, Patrice Hodonou, Manel, Arnaud, Vian, Emmanuel, Durand, Geoffroy, Forey, Nathalie, Voegele, Catherine, Zvereva, Maria, Hosen, Md Ismail, Meziani, Sonia, De Tilly, Berengere, Polo, Gilles, Lole, Olesia, Francois, Pauline, Delhomme, Tiffany Myriam, Carreira, Christine, Monteiro-Reis, Sara, Henrique, Rui, Abedi-Ardekani, Behnoush, Byrnes, Graham, Foll, Matthieu, Weiderpass, Elisabete, McKay, James, Jeronimo, Carmen, Scelo, Ghislaine, and Le Calvez-Kelm, Florence

Published
2019
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7. Perspective: An Extension of the STROBE Statement for Observational Studies in Nutritional Epidemiology (STROBE-nut): Explanation and Elaboration

Author

Hörnell, Agneta, Berg, Christina, Forsum, Elisabet, Larsson, Christel, Sonestedt, Emily, Åkesson, Agneta, Lachat, Carl, Hawwash, Dana, Kolsteren, Patrick, Byrnes, Graham, De Keyzer, Willem, Van Camp, John, Cade, Janet E, Greenwood, Darren C, Slimani, Nadia, Cevallos, Myriam, Egger, Matthias, Huybrechts, Inge, and Wirfält, Elisabet

Published
2017
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8. BAP1 Is Altered by Copy Number Loss, Mutation, and/or Loss of Protein Expression in More Than 70% of Malignant Peritoneal Mesotheliomas

Author

Leblay, Noémie, Leprêtre, Frédéric, Le Stang, Nolwenn, Gautier-Stein, Amandine, Villeneuve, Laurent, Isaac, Sylvie, Maillet, Denis, Galateau-Sallé, Françoise, Villenet, Céline, Sebda, Shéhérazade, Goracci, Alexandra, Byrnes, Graham, McKay, James D, Figeac, Martin, Glehen, Olivier, Gilly, François-Noël, Foll, Matthieu, Fernandez-Cuesta, Lynnette, and Brevet, Marie

Published
2017
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10. Sweetened beverages are associated with a higher risk of differentiated thyroid cancer in the EPIC cohort:a dietary pattern approach

Author

Zamora-Ros, Raul, Cayssials, Valerie, Cleries, Ramon, Torrents, Maria, Byrnes, Graham, Weiderpass, Elisabete, Sandstrom, Maria, Almquist, Martin, Boutron-Ruault, Marie-Christine, Tjonneland, Anne, Kyro, Cecilie, Katzke, Verena A., Le Cornet, Charlotte, Masala, Giovanna, Krogh, Vittorio, Iannuzzo, Gabriella, Tumino, Rosario, Milani, Lorenzo, Skeie, Guri, Ubago-Guisado, Esther, Amiano, Pilar, Chirlaque, Maria-Dolores, Ardanaz, Eva, Janzi, Suzanne, Eriksson, Linda, Freisling, Heinz, Heath, Alicia K., Rinaldi, Sabina, Agudo, Antonio, Zamora-Ros, Raul, Cayssials, Valerie, Cleries, Ramon, Torrents, Maria, Byrnes, Graham, Weiderpass, Elisabete, Sandstrom, Maria, Almquist, Martin, Boutron-Ruault, Marie-Christine, Tjonneland, Anne, Kyro, Cecilie, Katzke, Verena A., Le Cornet, Charlotte, Masala, Giovanna, Krogh, Vittorio, Iannuzzo, Gabriella, Tumino, Rosario, Milani, Lorenzo, Skeie, Guri, Ubago-Guisado, Esther, Amiano, Pilar, Chirlaque, Maria-Dolores, Ardanaz, Eva, Janzi, Suzanne, Eriksson, Linda, Freisling, Heinz, Heath, Alicia K., Rinaldi, Sabina, and Agudo, Antonio

Abstract

Background Dietary pattern analysis has gained particular interest, because it reflects the complexity of dietary intake. The aim of this study was to explore the associations between a posteriori dietary patterns, derived using a data-driven approach, and the risk of differentiated thyroid cancer (TC) in Europe. Methods This investigation included 450,064 adults from the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort. Dietary intake was assessed using validated country-specific dietary questionnaires. A posteriori dietary patterns were computed using principal component analyses. Cox regression was used to calculate multivariable adjusted hazard ratios (HRs) and 95% confidence intervals (CIs). Results After a mean follow-up time of 14 years, 712 first differentiated TCs were diagnosed. In the fully adjusted model, a dietary pattern characterized by alcohol consumption (basically beer and wine) was negatively associated with differentiated TC risk (HRQ4vs.Q1 = 0.75; 95% CI:0.60-0.94, P-trend = 0.005), while a dietary pattern rich in sweetened beverages was positively associated with differentiated TC risk (HRQ4vs.Q1 = 1.26; 95% CI:0.99-1.61; P-trend = 0.07). The remaining 8 dietary patterns were not related to differentiated TC risk. The intake of sweetened beverages was positively associated with differentiated TC risk (HR100mL/d = 1.05; 95% CI:1.00-1.11), especially with papillary TC risk (HR100mL/d = 1.07; 95% CI:1.01-1.13). Similar results were observed with sugary and artificially sweetened beverages. Conclusions The investigation of dietary patterns detected that the consumption of sweetened beverages was associated with a higher risk of differentiated thyroid cancer. Our results are in line with the general dietary recommendations of reducing the consumption of sweetened beverages.

Published
2023

12. Sweetened beverages are associated with a higher risk of differentiated thyroid cancer in the EPIC cohort : a dietary pattern approach

Author

Zamora-Ros, Raul, Cayssials, Valerie, Clèries, Ramon, Torrents, Maria, Byrnes, Graham, Weiderpass, Elisabete, Sandström, Maria, Almquist, Martin, Boutron-Ruault, Marie-Christine, Tjønneland, Anne, Kyrø, Cecilie, Katzke, Verena A., Le Cornet, Charlotte, Masala, Giovanna, Krogh, Vittorio, Iannuzzo, Gabriella, Tumino, Rosario, Milani, Lorenzo, Skeie, Guri, Ubago-Guisado, Esther, Amiano, Pilar, Chirlaque, María-Dolores, Ardanaz, Eva, Janzi, Suzanne, Eriksson, Linda, Freisling, Heinz, Heath, Alicia K., Rinaldi, Sabina, Agudo, Antonio, Zamora-Ros, Raul, Cayssials, Valerie, Clèries, Ramon, Torrents, Maria, Byrnes, Graham, Weiderpass, Elisabete, Sandström, Maria, Almquist, Martin, Boutron-Ruault, Marie-Christine, Tjønneland, Anne, Kyrø, Cecilie, Katzke, Verena A., Le Cornet, Charlotte, Masala, Giovanna, Krogh, Vittorio, Iannuzzo, Gabriella, Tumino, Rosario, Milani, Lorenzo, Skeie, Guri, Ubago-Guisado, Esther, Amiano, Pilar, Chirlaque, María-Dolores, Ardanaz, Eva, Janzi, Suzanne, Eriksson, Linda, Freisling, Heinz, Heath, Alicia K., Rinaldi, Sabina, and Agudo, Antonio

Abstract

Background: Dietary pattern analysis has gained particular interest, because it reflects the complexity of dietary intake. The aim of this study was to explore the associations between a posteriori dietary patterns, derived using a data-driven approach, and the risk of differentiated thyroid cancer (TC) in Europe. Methods: This investigation included 450,064 adults from the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort. Dietary intake was assessed using validated country-specific dietary questionnaires. A posteriori dietary patterns were computed using principal component analyses. Cox regression was used to calculate multivariable adjusted hazard ratios (HRs) and 95% confidence intervals (CIs). Results: After a mean follow-up time of 14 years, 712 first differentiated TCs were diagnosed. In the fully adjusted model, a dietary pattern characterized by alcohol consumption (basically beer and wine) was negatively associated with differentiated TC risk (HRQ4vs.Q1 = 0.75; 95% CI:0.60–0.94, P-trend = 0.005), while a dietary pattern rich in sweetened beverages was positively associated with differentiated TC risk (HRQ4vs.Q1 = 1.26; 95% CI:0.99–1.61; P-trend = 0.07). The remaining 8 dietary patterns were not related to differentiated TC risk. The intake of sweetened beverages was positively associated with differentiated TC risk (HR100mL/d = 1.05; 95% CI:1.00–1.11), especially with papillary TC risk (HR100mL/d = 1.07; 95% CI:1.01–1.13). Similar results were observed with sugary and artificially sweetened beverages. Conclusions: The investigation of dietary patterns detected that the consumption of sweetened beverages was associated with a higher risk of differentiated thyroid cancer. Our results are in line with the general dietary recommendations of reducing the consumption of sweetened beverages.

Published
2022
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14. A Rare Truncating BRCA2 Variant and Genetic Susceptibility to Upper Aerodigestive Tract Cancer

Author

Delahaye-Sourdeix, Manon, Anantharaman, Devasena, Timofeeva, Maria N., Gaborieau, Valérie, Chabrier, Amélie, Vallée, Maxime P., Lagiou, Pagona, Holcátová, Ivana, Richiardi, Lorenzo, Kjaerheim, Kristina, Agudo, Antonio, Castellsagué, Xavier, Macfarlane, Tatiana V., Barzan, Luigi, Canova, Cristina, Thakker, Nalin S., Conway, David I., Znaor, Ariana, Healy, Claire M., Ahrens, Wolfgang, Zaridze, David, Szeszenia-Dabrowska, Neonilia, Lissowska, Jolanta, Fabianova, Eleonora, Mates, Ioan Nicolae, Bencko, Vladimir, Foretova, Lenka, Janout, Vladimir, Curado, Maria Paula, Koifman, Sergio, Menezes, Ana, Wünsch-Filho, Victor, Eluf-Neto, José, Boffetta, Paolo, Fernández Garrote, Leticia, Polesel, Jerry, Lener, Marcin, Jaworowska, Ewa, Lubiński, Jan, Boccia, Stefania, Rajkumar, Thangarajan, Samant, Tanuja A., Mahimkar, Manoj B., Matsuo, Keitaro, Franceschi, Silvia, Byrnes, Graham, Brennan, Paul, and McKay, James D.

Published
2015
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15. A statistical framework to model the meeting-in-the-middle principle using metabolomic data: application to hepatocellular carcinoma in the EPIC study

Author

Assi, Nada, Fages, Anne, Vineis, Paolo, Chadeau-Hyam, Marc, Stepien, Magdalena, Duarte-Salles, Talita, Byrnes, Graham, Boumaza, Houda, Knüppel, Sven, Kühn, Tilman, Palli, Domenico, Bamia, Christina, Boshuizen, Hendriek, Bonet, Catalina, Overvad, Kim, Johansson, Mattias, Travis, Ruth, Gunter, Marc J., Lund, Eiliv, Dossus, Laure, Elena-Herrmann, Bénédicte, Riboli, Elio, Jenab, Mazda, Viallon, Vivian, and Ferrari, Pietro

Published
2015
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17. Maternal Age And Risk Of Type 1 Diabetes In Children

Author

Byrnes, Graham, Patterson, C. C., Dahlquist, G., Soltész, G., Gunn, Alistair J., Cutfield, Wayne S., Hofman, Paul L., Jeferries, Craig, Stene, Lars Christian, Joner, Geir, Bingley, Polly J., and Gale, Edwin A. M.

Published
2001

18. Dried venous blood samples for the detection and quantification of measles IgG using a commercial enzyme immunoassay

Author

Riddell Michaela A., Byrnes Graham B., Leydon Jennie A., and Kelly Heath A.

Subjects
Measles/immunology, Measles/diagnosis, Blood specimen collection/methods, Immunoenzyme techniques, Immunoglobulin G, Sensitivity and specificity, Seroepidemiologic studies, Public aspects of medicine, RA1-1270
Abstract

OBJECTIVES: To determine whether samples of dried venous blood (DVB) were an acceptable alternative to serum for detecting measles-specific IgG in a commercial enzyme immunoassay. METHODS: Paired samples of serum and DVB were collected from 98 suspected cases of measles and 1153 schoolchildren in Victoria, Australia. All samples were tested using the Dade Behring Enzygnost® Anti-Measles-Virus/IgG immunoassay. DVB samples were eluted using either the sample buffer provided with the kit or 5% dry milk powder in phosphate-buffered saline-Tween 20. FINDINGS: DVB samples eluted by sample buffer showed significantly better linear correlation to the serum samples than did DVB samples eluted in 5% dry milk in phosphate-buffered saline-Tween 20. To improve the comparability of serum and DVB samples an adjustment factor of 1.28 was applied to the optical density (OD) values of DVB. This adjustment also enabled quantification of the titre of measles IgG in mIU/ml directly from the OD value using the alpha calculation as specified by the kit protocol. For DVB samples stored for less than six months at 4 °C, the assay showed an overall sensitivity of 98.4% and a specificity of 97.2% compared with the results of serum testing. CONCLUSION: These results illustrate the potential for DVB samples to be widely used with the Dade Behring enzyme immunoassay system for determining the immunity of the individual and the population to the measles virus.

Published
2003

19. Meat, eggs, dairy products, and risk of breast cancer in the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort

Author

Pala, Valeria, Krogh, Vittorio, Berrino, Franco, Sieri, Sabina, Grioni, Sara, Tjønneland, Anne, Olsen, Anja, Jakobsen, Marianne Uhre, Overvad, Kim, Clavel-Chapelon, Françoise, Boutron-Ruault, Marie-Christine, Romieu, Isabelle, Linseisen, Jakob, Rohrmann, Sabine, Boeing, Heiner, Steffen, Annika, Trichopoulou, Antonia, Benetou, Vassiliki, Naska, Androniki, Vineis, Paolo, Tumino, Rosario, Panico, Salvatore, Masala, Giovanna, Agnoli, Claudia, Engeset, Dagrun, Skeie, Guri, Lund, Eiliv, Ardanaz, Eva, Navarro, Carmen, Sánchez, Maria-José, Amiano, Pilar, Svatetz, Carlos Alberto Gonzalez, Rodriguez, Laudina, Wirfält, Elisabet, Manjer, Jonas, Lenner, Per, Hallmans, Göran, Peeters, Petra HM, van Gils, Carla H, Bueno-de-Mesquita, H Bas, van Duijnhoven, Fränzel JB, Key, Timothy J, Spencer, Elizabeth, Bingham, Sheila, Khaw, Kay-Tee, Ferrari, Pietro, Byrnes, Graham, Rinaldi, Sabina, Norat, Teresa, Michaud, Dominique S, and Riboli, Elio

Published
2009
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20. Plasma phospholipid fatty acid profiles and their association with food intakes: results from a cross-sectional study within the European Prospective Investigation into Cancer and Nutrition

Author

Saadatian-Elahi, Mitra, Slimani, Nadia, Chajès, Véronique, Jenab, Mazda, Goudable, Joëlle, Biessy, Carine, Ferrari, Pietro, Byrnes, Graham, Autier, Philippe, Peeters, Petra HM, Ocké, Marga, Bueno de Mesquita, Bas, Johansson, Ingegerd, Hallmans, Göran, Manjer, Jonas, Wirfält, Elisabet, González, Carlos A, Navarro, Carmen, Martinez, Carmen, Amiano, Pilar, Suárez, Laudina Rodriguez, Ardanaz, Eva, Tjønneland, Anne, Halkjaer, Jytte, Overvad, Kim, Jakobsen, Marianne Uhre, Berrino, Franco, Pala, Valeria, Palli, Domenico, Tumino, Rosario, Vineis, Paolo, Santucci de Magistris, Maria, Spencer, Elisabeth A, Crowe, Francesca L, Bingham, Sheila, Khaw, Kay-Tee, Linseisen, Jakob, Rohrmann, Sabine, Boeing, Heiner, Noethlings, Ute, Olsen, Karina Standahl, Skeie, Guri, Lund, Eiliv, Trichopoulou, Antonia, Oustoglou, Erifili, Clavel-Chapelon, Françoise, and Riboli, Elio

Published
2009
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21. Blood polyphenol concentrations and differentiated thyroid carcinoma in women from the European Prospective Investigation into Cancer and Nutrition (EPIC) study

Author

Zamora-Ros, Raul, Lujan-Barroso, Leila, Achaintre, David, Franceschi, Silvia, Kyro, Cecilie, Overvad, Kim, Tjonneland, Anne, Truong, Therese, Lecuyer, Lucie, Boutron-Ruault, Marie-Christine, Katzke, Verena, Johnson, Theron S., Schulze, Matthias B., Trichopoulou, Antonia, Peppa, Eleni, La Vechia, Carlo, Masala, Giovanna, Pala, Valeria, Panico, Salvatore, Tumino, Rosario, Ricceri, Fulvio, Skeie, Guri, Quiros, J. Ramon, Rodriguez-Barranco, Miguel, Amiano, Pilar, Chirlaque, Maria-Dolores, Ardanaz, Eva, Almquist, Martin, Hennings, Joakim, Vermeulen, Roel, Wareham, Nicholas J., Tong, Tammy Y. N., Aune, Dagfinn, Byrnes, Graham, Weiderpass, Elisabete, Scalbert, Augustin, Rinaldi, Sabina, Agudo, Antonio, Zamora-Ros, Raul, Lujan-Barroso, Leila, Achaintre, David, Franceschi, Silvia, Kyro, Cecilie, Overvad, Kim, Tjonneland, Anne, Truong, Therese, Lecuyer, Lucie, Boutron-Ruault, Marie-Christine, Katzke, Verena, Johnson, Theron S., Schulze, Matthias B., Trichopoulou, Antonia, Peppa, Eleni, La Vechia, Carlo, Masala, Giovanna, Pala, Valeria, Panico, Salvatore, Tumino, Rosario, Ricceri, Fulvio, Skeie, Guri, Quiros, J. Ramon, Rodriguez-Barranco, Miguel, Amiano, Pilar, Chirlaque, Maria-Dolores, Ardanaz, Eva, Almquist, Martin, Hennings, Joakim, Vermeulen, Roel, Wareham, Nicholas J., Tong, Tammy Y. N., Aune, Dagfinn, Byrnes, Graham, Weiderpass, Elisabete, Scalbert, Augustin, Rinaldi, Sabina, and Agudo, Antonio

Abstract

Background: Polyphenols are natural compounds with anticarcinogenic properties in cellular and animal models, but epidemiological evidence determining the associations of these compounds with thyroid cancer (TC) is lacking. Objectives: The aim of this study was to evaluate the relations between blood concentrations of 36 polyphenols and TC risk in EPIC (the European Prospective Investigation into Cancer and Nutrition). Methods: A nested case-control study was conducted on 273 female cases (210 papillary, 45 follicular, and 18 not otherwise specified TC tumors) and 512 strictly matched controls. Blood polyphenol concentrations were analyzed by HPLC coupled to tandem MS after enzymatic hydrolysis. Results: Using multivariable-adjusted conditional logistic regression models, caffeic acid (ORlog2: 0.55; 95% CI: 0.33, 0.93) and its dehydrogenated metabolite, 3,4-dihydroxyphenylpropionic acid (ORlog2: 0.84; 95% CI: 0.71, 0.99), were inversely associated with differentiated TC risk. Similar results were observed for papillary TC, but not for follicular TC. Ferulic acid was also inversely associated only with papillary TC (ORlog2: 0.68; 95% CI: 0.51, 0.91). However, none of these relations was significant after Bonferroni correction for multiple testing. No association was observed for any of the remaining polyphenols with total differentiated, papillary, or follicular TC. Conclusions: Blood polyphenol concentrations were mostly not associated with differentiated TC risk in women, although our study raises the possibility that high blood concentrations of caffeic, 3,4-dihydroxyphenylpropionic, and ferulic acids may be related to a lower papillary TC risk.

Published
2021
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22. Thyroid-Stimulating Hormone, Thyroglobulin, and Thyroid Hormones and Risk of Differentiated Thyroid Carcinoma: The EPIC Study

Author

Rinaldi, Sabina, Plummer, Martyn, Biessy, Carine, Tsilidis, Konstantinos K., Østergaard, Jane Nautrup, Overvad, Kim, Tjønneland, Anne, Halkjær, Jytte, Boutron-Ruault, Marie-Christine, Clavel-Chapelon, Françoise, Dossus, Laure, Kaaks, Rudolf, Lukanova, Annekatrin, Boeing, Heiner, Trichopoulou, Antonia, Lagiou, Pagona, Trichopoulos, Dimitrios, Palli, Domenico, Agnoli, Claudia, Tumino, Rosario, Vineis, Paolo, Panico, Salvatore, Bueno-de-Mesquita, Bas H., Peeters, Petra H, Weiderpass, Elisabete, Lund, Eiliv, Quirós, Ramón J., Agudo, Antonio, Molina, Esther, Larrañaga, Nerea, Navarro, Carmen, Ardanaz, Eva, Manjer, Jonas, Almquist, Martin, Sandström, Maria, Hennings, Joakim, Khaw, Kay-Tee, Schmidt, Julie, Travis, Ruth C., Byrnes, Graham, Scalbert, Augustin, Romieu, Isabelle, Gunter, Marc, Riboli, Elio, and Franceschi, Silvia

Published
2014
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23. Rare, evolutionarily unlikely missense substitutions in ATM Confer increased risk of breast cancer

Author

Tavtigian, Sean V., Oefner, Peter J., Babikyan, Davit, Hartmann, Anne, Chenevix-Trench, Georgia, John, Esther M., Healey, Sue, Le Calvez-Kelm, Florence, Lesueur, Fabienne, Andrulis, Irene L., Southey, Melissa C., Byrnes, Graham B., Shu-Chun Chuang, Forey, Nathalie, Voegele, Catherine, Webb, Penelope M., Feuchtinger, Corinna, Gioia, Lydie, Hall, Janet, Hashibe, Mia, Whitemanv, David C., Sangrajrang, Suleeporn, Herte, Barbara, McKay-Chopin, Sandrine, Thomas, Alun, Vallee, Maxime P., and Hopper, John L.

Subjects
Gene mutations -- Analysis, Human evolution -- Analysis, Ataxia telangiectasia -- Genetic aspects, Ataxia telangiectasia -- Research, Breast cancer -- Risk factors, Biological sciences
Abstract

Several case-studies are conducted to explain the rare and evolutionary ATM (ataxia telangiectasia [MIM 208900]) mutations, which usually lead to increase risk of breast cancer in humans. The breast cancer risk is shown to be highly enhanced by the protein-truncating and splice-junction variants of the ATM mutations.

Published
2009

25. Tobacco smoking among chrysotile asbestos workers in Asbest in the Russian Federation

Author

Olsson, Ann, Kovalevskiy, Evgeny V, Talibov, Madar, Moissonnier, Monika, Byrnes, Graham, Bouaoun, Liacine, Schonfeld, Sara J, Feletto, Eleonora, Kashanskiy, Sergey V, Ostroumova, Evgenia, Kromhout, Hans, Bukhtiyarov, Igor V, Schüz, Joachim, IRAS OH Epidemiology Chemical Agents, dIRAS RA-2, IRAS OH Epidemiology Chemical Agents, and dIRAS RA-2

Subjects
Adult, Male, Asbestos, Serpentine, Cross-sectional study, Miners, medicine.disease_cause, Logistic regression, Asbestos, Occupational safety and health, smoking, cross sectional studies, Russia, Cohort Studies, 03 medical and health sciences, 0302 clinical medicine, Environmental health, Occupational Exposure, Surveys and Questionnaires, Chrysotile, medicine, Tobacco Smoking, Humans, 030212 general & internal medicine, Workplace, Aged, business.industry, Confounding, Public Health, Environmental and Occupational Health, Dust, Middle Aged, asbestos, Cross-Sectional Studies, 030220 oncology & carcinogenesis, Cohort, Female, Particulate Matter, business, Historical Cohort
Abstract

ObjectivesA historical cohort study of cancer mortality is being conducted among workers in a chrysotile mine and its enrichment factories in the town of Asbest, Russian Federation. Because individual-level information on tobacco use is not available for Asbest Chrysotile Cohort members, a cross-sectional survey of smoking behaviours was conducted among active and retired workers.MethodsSelf-administered questionnaires were completed by active workers during meetings organised by occupational safety personnel. Retired workers completed questionnaires during meetings of the Veterans Council or were interviewed via telephone or in person. Of the respondents, 46% could be linked to the Asbest Chrysotile Cohort. Among those, logistic regression models were used to assess associations between smoking and cumulative dust exposure.ResultsAmong men, smoking prevalence was high and relatively consistent across birth decades (average, 66%), and was similar in workers across all levels of cumulative dust exposure (p trend, 0.44). Among women, the prevalence increased from ConclusionsOur study suggests that cross-sectional surveys may be a useful tool for understanding the potential health impact from smoking in occupational cohorts, including possible confounding by smoking. This survey showed that adjustment at the age group level among women is needed to reduce residual confounding and account for smoking patterns, which have changed substantially over time.

Published
2020

26. Polyphenol intake and differentiated thyroid cancer risk in the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort

Author

Zamora-Ros, Raul, Cayssials, Valerie, Franceschi, Silvia, Kyrø, Cecilie, Weiderpass, Elisabete, Hennings, Joakim, Sandström, Maria, Tjønneland, Anne, Olsen, Anja, Overvad, Kim, Boutron-Ruault, Marie-Christine, Truong, Thérèse, Mancini, Francesca Romana, Katzke, Verena, Kühn, Tilman, Boeing, Heiner, Trichopoulou, Antonia, Karakatsani, Anna, Martimianaki, Georgia, Palli, Domenico, Krogh, Vittorio, Panico, Salvatore, Tumino, Rosario, Sacerdote, Carlotta, Lasheras, Cristina, Rodríguez-Barranco, Miguel, Amiano, Pilar, Colorado-Yohar, Sandra M., Ardanaz, Eva, Almquist, Martin, Ericson, Ulrika, Bueno-de-Mesquita, H. Bas, Vermeulen, Roel, Schmidt, Julie A., Byrnes, Graham, Scalbert, Augustin, Agudo, Antonio, Rinaldi, Sabina, Zamora-Ros, Raul, Cayssials, Valerie, Franceschi, Silvia, Kyrø, Cecilie, Weiderpass, Elisabete, Hennings, Joakim, Sandström, Maria, Tjønneland, Anne, Olsen, Anja, Overvad, Kim, Boutron-Ruault, Marie-Christine, Truong, Thérèse, Mancini, Francesca Romana, Katzke, Verena, Kühn, Tilman, Boeing, Heiner, Trichopoulou, Antonia, Karakatsani, Anna, Martimianaki, Georgia, Palli, Domenico, Krogh, Vittorio, Panico, Salvatore, Tumino, Rosario, Sacerdote, Carlotta, Lasheras, Cristina, Rodríguez-Barranco, Miguel, Amiano, Pilar, Colorado-Yohar, Sandra M., Ardanaz, Eva, Almquist, Martin, Ericson, Ulrika, Bueno-de-Mesquita, H. Bas, Vermeulen, Roel, Schmidt, Julie A., Byrnes, Graham, Scalbert, Augustin, Agudo, Antonio, and Rinaldi, Sabina

Abstract

Polyphenols are bioactive compounds with several anticarcinogenic activities; however, human data regarding associations with thyroid cancer (TC) is still negligible. Our aim was to evaluate the association between intakes of total, classes and subclasses of polyphenols and risk of differentiated TC and its main subtypes, papillary and follicular, in a European population. The European Prospective Investigation into Cancer and Nutrition cohort included 476,108 men and women from 10 European countries. During a mean follow-up of 14 years, there were 748 incident differentiated TC cases, including 601 papillary and 109 follicular tumors. Polyphenol intake was estimated at baseline using validated center/country-specific dietary questionnaires and the Phenol-Explorer database. In multivariable-adjusted Cox regression models, no association between total polyphenol and the risks of overall differentiated TC (HRQ4 vs. Q1 = 0.99, 95% confidence interval [CI] 0.77-1.29), papillary (HRQ4 vs. Q1 = 1.06, 95% CI 0.80-1.41) or follicular TC (HRQ4 vs. Q1 = 1.10, 95% CI 0.55-2.22) were found. No associations were observed either for flavonoids, phenolic acids or the rest of classes and subclasses of polyphenols. After stratification by body mass index (BMI), an inverse association between the intake of polyphenols (p-trend = 0.019) and phenolic acids (p-trend = 0.007) and differentiated TC risk in subjects with BMI >= 25 was observed. In conclusion, our study showed no associations between dietary polyphenol intake and differentiated TC risk; although further studies are warranted to investigate the potential protective associations in overweight and obese individuals.

Published
2020
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27. Occupational cohort study of current and former workers exposed to chrysotile in mine and processing facilities in Asbest, the Russian Federation: Cohort profile of the Asbest Chrysotile Cohort study

Author

IRAS OH Epidemiology Chemical Agents, dIRAS RA-2, Schüz, Joachim, Bukhtiyarov, Igor, Olsson, Ann, Moissonnier, Monika, Ostroumova, Evgenia, Feletto, Eleonora, Schonfeld, Sara J., Byrnes, Graham, Tskhomariia, Iraklii, McCormack, Valerie, Straif, Kurt, Kashanskiy, Sergey, Morozova, Tatiana, Kromhout, Hans, Kovalevskiy, Evgeny, IRAS OH Epidemiology Chemical Agents, dIRAS RA-2, Schüz, Joachim, Bukhtiyarov, Igor, Olsson, Ann, Moissonnier, Monika, Ostroumova, Evgenia, Feletto, Eleonora, Schonfeld, Sara J., Byrnes, Graham, Tskhomariia, Iraklii, McCormack, Valerie, Straif, Kurt, Kashanskiy, Sergey, Morozova, Tatiana, Kromhout, Hans, and Kovalevskiy, Evgeny

Published
2020

28. Tobacco smoking among chrysotile asbestos workers in Asbest in the Russian Federation

Author

IRAS OH Epidemiology Chemical Agents, dIRAS RA-2, Olsson, Ann, Kovalevskiy, Evgeny V, Talibov, Madar, Moissonnier, Monika, Byrnes, Graham, Bouaoun, Liacine, Schonfeld, Sara J, Feletto, Eleonora, Kashanskiy, Sergey V, Ostroumova, Evgenia, Kromhout, Hans, Bukhtiyarov, Igor V, Schüz, Joachim, IRAS OH Epidemiology Chemical Agents, dIRAS RA-2, Olsson, Ann, Kovalevskiy, Evgeny V, Talibov, Madar, Moissonnier, Monika, Byrnes, Graham, Bouaoun, Liacine, Schonfeld, Sara J, Feletto, Eleonora, Kashanskiy, Sergey V, Ostroumova, Evgenia, Kromhout, Hans, Bukhtiyarov, Igor V, and Schüz, Joachim

Published
2020

29. Blood polyphenol concentrations and differentiated thyroid carcinoma in women from the European Prospective Investigation into Cancer and Nutrition (EPIC) study

Author

Zamora-Ros, Raul, primary, Lujan-Barroso, Leila, additional, Achaintre, David, additional, Franceschi, Silvia, additional, Kyrø, Cecilie, additional, Overvad, Kim, additional, Tjønneland, Anne, additional, Truong, Therese, additional, Lecuyer, Lucie, additional, Boutron-Ruault, Marie-Christine, additional, Katzke, Verena, additional, Johnson, Theron S, additional, Schulze, Matthias B, additional, Trichopoulou, Antonia, additional, Peppa, Eleni, additional, La Vechia, Carlo, additional, Masala, Giovanna, additional, Pala, Valeria, additional, Panico, Salvatore, additional, Tumino, Rosario, additional, Ricceri, Fulvio, additional, Skeie, Guri, additional, Quirós, J Ramón, additional, Rodriguez-Barranco, Miguel, additional, Amiano, Pilar, additional, Chirlaque, María-Dolores, additional, Ardanaz, Eva, additional, Almquist, Martin, additional, Hennings, Joakim, additional, Vermeulen, Roel, additional, Wareham, Nicholas J, additional, Tong, Tammy YN, additional, Aune, Dagfinn, additional, Byrnes, Graham, additional, Weiderpass, Elisabete, additional, Scalbert, Augustin, additional, Rinaldi, Sabina, additional, and Agudo, Antonio, additional

Published
2021
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30. Development of Sensitive Droplet Digital PCR Assays for Detecting Urinary TERT Promoter Mutations as Non-Invasive Biomarkers for Detection of Urothelial Cancer

Author

Hosen, Md Ismail, primary, Forey, Nathalie, additional, Durand, Geoffroy, additional, Voegele, Catherine, additional, Bilici, Selin, additional, Avogbe, Patrice Hodonou, additional, Delhomme, Tiffany Myriam, additional, Foll, Matthieu, additional, Manel, Arnaud, additional, Vian, Emmanuel, additional, Meziani, Sonia, additional, De Tilly, Berengere, additional, Polo, Gilles, additional, Lole, Olesia, additional, Francois, Pauline, additional, Boureille, Antoine, additional, Pisarev, Eduard, additional, Salas, Andrei R. O. S. E., additional, Monteiro-Reis, Sara, additional, Henrique, Rui, additional, Byrnes, Graham, additional, Jeronimo, Carmen, additional, Scelo, Ghislaine, additional, McKay, James D., additional, Calvez-Kelm, Florence Le, additional, and Zvereva, Maria, additional

Published
2020
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33. Occupational cohort study of current and former workers exposed to chrysotile in mine and processing facilities in Asbest, the Russian Federation: Cohort profile of the Asbest Chrysotile Cohort study

Author

Schüz, Joachim, primary, Bukhtiyarov, Igor, additional, Olsson, Ann, additional, Moissonnier, Monika, additional, Ostroumova, Evgenia, additional, Feletto, Eleonora, additional, Schonfeld, Sara J, additional, Byrnes, Graham, additional, Tskhomariia, Iraklii, additional, McCormack, Valerie, additional, Straif, Kurt, additional, Kashanskiy, Sergey, additional, Morozova, Tatiana, additional, Kromhout, Hans, additional, and Kovalevskiy, Evgeny, additional

Published
2020
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34. Needlestack: an ultra-sensitive variant caller for multi-sample next generation sequencing data

Author

Delhomme, Tiffany M, primary, Avogbe, Patrice H, additional, Gabriel, Aurélie A G, additional, Alcala, Nicolas, additional, Leblay, Noemie, additional, Voegele, Catherine, additional, Vallée, Maxime, additional, Chopard, Priscilia, additional, Chabrier, Amélie, additional, Abedi-Ardekani, Behnoush, additional, Gaborieau, Valérie, additional, Holcatova, Ivana, additional, Janout, Vladimir, additional, Foretová, Lenka, additional, Milosavljevic, Sasa, additional, Zaridze, David, additional, Mukeriya, Anush, additional, Brambilla, Elisabeth, additional, Brennan, Paul, additional, Scelo, Ghislaine, additional, Fernandez-Cuesta, Lynnette, additional, Byrnes, Graham, additional, Calvez-Kelm, Florence L, additional, McKay, James D, additional, and Foll, Matthieu, additional

Published
2020
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35. Autier et al. Respond to “A Sunbed Epidemic?”

Author

Autier, Philippe, Tryggvadóttir, Laufey, Sigurdsson, Thorgeir, Ólafsdóttir, Elínborg, Sigurgeirsson, Bardur, Jonasson, Jon G., Olafsson, Jon H., Byrnes, Graham B., Héry, Clarisse, Doré, Jean-François, and Boniol, Mathieu

Published
2010
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38. Association between pre-diagnostic circulating vitamin D concentration and risk of colorectal cancer in European populations: a nested case-control study

Author

Jenab, Mazda, Bueno-de-Mesquita, Bas H, Ferrari, Pietro, van Duijnhoven, Franzel J B, Norat, Teresa, Pischon, Tobias, Jansen, Eugène H J M, Slimani, Nadia, Byrnes, Graham, Rinaldi, Sabina, Tjønneland, Anne, Olsen, Anja, Overvad, Kim, Boutron-Ruault, Marie-Christine, Clavel-Chapelon, Françoise, Morois, Sophie, Kaaks, Rudolf, Linseisen, Jakob, Boeing, Heiner, Bergmann, Manuela M, Trichopoulou, Antonia, Misirli, Gesthimani, Trichopoulos, Dimitrios, Berrino, Franco, Vineis, Paolo, Panico, Salvatore, Palli, Domenico, Tumino, Rosario, Ros, Martine M, van Gils, Carla H, Peeters, Petra H, Brustad, Magritt, Lund, Eiliv, Tormo, María-José, Ardanaz, Eva, Rodríguez, Laudina, Sánchez, Maria-José, Dorronsoro, Miren, Gonzalez, Carlos A, Hallmans, Göran, Palmqvist, Richard, Roddam, Andrew, Key, Timothy J, Khaw, Kay-Tee, Autier, Philippe, Hainaut, Pierre, and Riboli, Elio

Published
2010
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39. Strengthening the Reporting of Observational Studies in Epidemiology-Nutritional Epidemiology (STROBE-nut): An Extension of the STROBE Statement

Author

Lachat, Carl, Hawwash, Dana, Ocké, Marga C., Berg, Christina, Forsum, Elisabet, Hörnell, Agneta, Larsson, Christel, Sonestedt, Emily, Wirfält, Elisabet, Åkesson, Agneta, Kolsteren, Patrick, Byrnes, Graham, De Keyzer, Willem, Van Camp, John, Cade, Janet E., Slimani, Nadia, Cevallos, Myriam, Egger, Matthias, and Huybrechts, Inge

Subjects
Nutritional assessment -- Reports, Epidemiology -- Analysis, Biological sciences
Abstract

Background Concerns have been raised about the quality of reporting in nutritional epidemiology. Research reporting guidelines such as the Strengthening the Reporting of Observational Studies in Epidemiology (STROBE) statement can improve quality of reporting in observational studies. Herein, we propose recommendations for reporting nutritional epidemiology and dietary assessment research by extending the STROBE statement into Strengthening the Reporting of Observational Studies in Epidemiology-Nutritional Epidemiology (STROBE-nut). Methods and Findings Recommendations for the reporting of nutritional epidemiology and dietary assessment research were developed following a systematic and consultative process, coordinated by a multidisciplinary group of 21 experts. Consensus on reporting guidelines was reached through a three-round Delphi consultation process with 53 external experts. In total, 24 recommendations for nutritional epidemiology were added to the STROBE checklist. Conclusion When used appropriately, reporting guidelines for nutritional epidemiology can contribute to improve reporting of observational studies with a focus on diet and health., Author(s): Carl Lachat 1,2,*, Dana Hawwash 1, Marga C. Ocké 3, Christina Berg 4, Elisabet Forsum 5, Agneta Hörnell 6, Christel Larsson 4, Emily Sonestedt 7, Elisabet Wirfält 7, Agneta [...]

Published
2016
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40. Coffee and tea drinking in relation to the risk of differentiated thyroid carcinoma : results from the European Prospective Investigation into Cancer and Nutrition (EPIC) study

Author

Zamora-Ros, Raul, Alghamdi, Muath A., Cayssials, Valerie, Franceschi, Silvia, Almquist, Martin, Hennings, Joakim, Sandström, Maria, Tsilidis, Konstantinos K., Weiderpass, Elisabete, Boutron-Ruault, Marie-Christine, Hammer Bech, Bodil, Overvad, Kim, Tjonneland, Anne, Petersen, Kristina E. N., Mancini, Francesca Romana, Mahamat-Saleh, Yahya, Bonnet, Fabrice, Kuehn, Tilman, Fortner, Renee T., Boeing, Heiner, Trichopoulou, Antonia, Bamia, Christina, Martimianaki, Georgia, Masala, Giovanna, Grioni, Sara, Panico, Salvatore, Tumino, Rosario, Fasanelli, Francesca, Skeie, Guri, Braaten, Tonje, Lasheras, Cristina, Salamanca-Fernandez, Elena, Amiano, Pilar, Chirlaque, Maria-Dolores, Barricarte, Aurelio, Manjer, Jonas, Wallstrom, Peter, Bueno-de-Mesquita, H. Bas, Peeters, Petra H., Khaw, Kay-Thee, Wareham, Nicholas J., Schmidt, Julie A., Aune, Dagfinn, Byrnes, Graham, Scalbert, Augustin, Agudo, Antonio, Rinaldi, Sabina, Zamora-Ros, Raul, Alghamdi, Muath A., Cayssials, Valerie, Franceschi, Silvia, Almquist, Martin, Hennings, Joakim, Sandström, Maria, Tsilidis, Konstantinos K., Weiderpass, Elisabete, Boutron-Ruault, Marie-Christine, Hammer Bech, Bodil, Overvad, Kim, Tjonneland, Anne, Petersen, Kristina E. N., Mancini, Francesca Romana, Mahamat-Saleh, Yahya, Bonnet, Fabrice, Kuehn, Tilman, Fortner, Renee T., Boeing, Heiner, Trichopoulou, Antonia, Bamia, Christina, Martimianaki, Georgia, Masala, Giovanna, Grioni, Sara, Panico, Salvatore, Tumino, Rosario, Fasanelli, Francesca, Skeie, Guri, Braaten, Tonje, Lasheras, Cristina, Salamanca-Fernandez, Elena, Amiano, Pilar, Chirlaque, Maria-Dolores, Barricarte, Aurelio, Manjer, Jonas, Wallstrom, Peter, Bueno-de-Mesquita, H. Bas, Peeters, Petra H., Khaw, Kay-Thee, Wareham, Nicholas J., Schmidt, Julie A., Aune, Dagfinn, Byrnes, Graham, Scalbert, Augustin, Agudo, Antonio, and Rinaldi, Sabina

Abstract

Purpose: Coffee and tea constituents have shown several anti-carcinogenic activities in cellular and animal studies, including against thyroid cancer (TC). However, epidemiological evidence is still limited and inconsistent. Therefore, we aimed to investigate this association in a large prospective study. Methods: The study was conducted in the EPIC (European Prospective Investigation into Cancer and Nutrition) cohort, which included 476,108 adult men and women. Coffee and tea intakes were assessed through validated country-specific dietary questionnaires. Results: During a mean follow-up of 14 years, 748 first incident differentiated TC cases (including 601 papillary and 109 follicular TC) were identified. Coffee consumption (per 100 mL/day) was not associated either with total differentiated TC risk (HRcalibrated 1.00, 95% CI 0.97–1.04) or with the risk of TC subtypes. Tea consumption (per 100 mL/day) was not associated with the risk of total differentiated TC (HRcalibrated 0.98, 95% CI 0.95–1.02) and papillary tumor (HRcalibrated 0.99, 95% CI 0.95–1.03), whereas an inverse association was found with follicular tumor risk (HRcalibrated 0.90, 95% CI 0.81–0.99), but this association was based on a sub-analysis with a small number of cancer cases. Conclusions: In this large prospective study, coffee and tea consumptions were not associated with TC risk.

Published
2019
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41. Survival of glioma patients in relation to mobile phone use in Denmark, Finland and Sweden

Author

Olsson, Ann, Bouaoun, Liacine, Auvinen, Anssi, Feychting, Maria, Johansen, Christoffer, Mathiesen, Tiit, Melin, Beatrice S., Lahkola, Anna, Larjavaara, Suvi, Villegier, Anne-Sophie, Byrnes, Graham, Deltour, Isabelle, Schüz, Joachim, Olsson, Ann, Bouaoun, Liacine, Auvinen, Anssi, Feychting, Maria, Johansen, Christoffer, Mathiesen, Tiit, Melin, Beatrice S., Lahkola, Anna, Larjavaara, Suvi, Villegier, Anne-Sophie, Byrnes, Graham, Deltour, Isabelle, and Schüz, Joachim

Abstract

Purpose: Gliomas are the most common cancer of the brain, with a poor prognosis in particular for glioblastoma. In 2014, a study suggested reduced survival in relation to latency of mobile phone use among glioblastoma patients. A joint epidemiological/experimental project to study effects of RF-EMF on tumor development and progression was established. The current analysis relates to the epidemiological part and addresses whether pre-diagnostic mobile phone use was associated with survival among glioma patients. Methods: Glioma cases (n = 806) previously enrolled in a collaborative population-based case–control study in Denmark, Finland and Sweden were followed up for survival. Vital status, date of death, date of emigration, or date last known to be alive was obtained based on registry linkages with a unique personal ID in each country. Cox regression models were used to calculate hazard ratios (HR) and 95% confidence intervals (CI) stratified by country. Covariates investigated were sex, age, education, histology, treatment, anatomic location and marital status. Results: No indication of reduced survival among glioblastoma patients was observed for various measures of mobile phone use (ever regular use, time since start of regular use, cumulative call time overall or in the last 12 months) relative to no or non-regular use. All significant associations suggested better survival for mobile phone users. Results were similar for high-grade and low-grade gliomas. Conclusions: We found no evidence of reduced survival among glioma patients in relation to previous mobile phone use.

Published
2019
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42. Is adjustment for smoking needed in a cohort study of cancer mortality among chrysotile asbestos factory and mine workers?

Author

One Health Chemisch, dIRAS RA-2, Olsson, Ann, Talibov, Madar, Kovalevskiy, Evgeny V., Byrnes, Graham, Schonfeld, Sara, Feletto, Eleonora, Kashanskiy, Sergey V., Moissonnier, Monika, Ostroumova, Evgenia, Straif, Kurt, Kromhout, Hans, Bukhtiyarov, Igor V., Schüz, Joachim, One Health Chemisch, dIRAS RA-2, Olsson, Ann, Talibov, Madar, Kovalevskiy, Evgeny V., Byrnes, Graham, Schonfeld, Sara, Feletto, Eleonora, Kashanskiy, Sergey V., Moissonnier, Monika, Ostroumova, Evgenia, Straif, Kurt, Kromhout, Hans, Bukhtiyarov, Igor V., and Schüz, Joachim

Published
2019

43. Coffee and tea drinking in relation to the risk of differentiated thyroid carcinoma: results from the European Prospective Investigation into Cancer and Nutrition (EPIC) study

Author

MS MDL 1, Epi Infectieziekten Team 2, Epi Kanker Team 1, Cancer, JC onderzoeksprogramma Kanker, Zamora-Ros, Raul, Alghamdi, Muath A., Cayssials, Valerie, Franceschi, Silvia, Almquist, Martin, Hennings, Joakim, Sandström, Maria, Tsilidis, Konstantinos K., Weiderpass, Elisabete, Boutron-Ruault, Marie Christine, Hammer Bech, Bodil, Overvad, Kim, Tjønneland, Anne, Petersen, Kristina E.N., Mancini, Francesca Romana, Mahamat-Saleh, Yahya, Bonnet, Fabrice, Kühn, Tilman, Fortner, Renée T., Boeing, Heiner, Trichopoulou, Antonia, Bamia, Christina, Martimianaki, Georgia, Masala, Giovanna, Grioni, Sara, Panico, Salvatore, Tumino, Rosario, Fasanelli, Francesca, Skeie, Guri, Braaten, Tonje, Lasheras, Cristina, Salamanca-Fernández, Elena, Amiano, Pilar, Chirlaque, Maria Dolores, Barricarte, Aurelio, Manjer, Jonas, Wallström, Peter, Bueno-de-Mesquita, H. Bas, Peeters, Petra H., Khaw, Kay Thee, Wareham, Nicholas J., Schmidt, Julie A., Aune, Dagfinn, Byrnes, Graham, Scalbert, Augustin, Agudo, Antonio, Rinaldi, Sabina, MS MDL 1, Epi Infectieziekten Team 2, Epi Kanker Team 1, Cancer, JC onderzoeksprogramma Kanker, Zamora-Ros, Raul, Alghamdi, Muath A., Cayssials, Valerie, Franceschi, Silvia, Almquist, Martin, Hennings, Joakim, Sandström, Maria, Tsilidis, Konstantinos K., Weiderpass, Elisabete, Boutron-Ruault, Marie Christine, Hammer Bech, Bodil, Overvad, Kim, Tjønneland, Anne, Petersen, Kristina E.N., Mancini, Francesca Romana, Mahamat-Saleh, Yahya, Bonnet, Fabrice, Kühn, Tilman, Fortner, Renée T., Boeing, Heiner, Trichopoulou, Antonia, Bamia, Christina, Martimianaki, Georgia, Masala, Giovanna, Grioni, Sara, Panico, Salvatore, Tumino, Rosario, Fasanelli, Francesca, Skeie, Guri, Braaten, Tonje, Lasheras, Cristina, Salamanca-Fernández, Elena, Amiano, Pilar, Chirlaque, Maria Dolores, Barricarte, Aurelio, Manjer, Jonas, Wallström, Peter, Bueno-de-Mesquita, H. Bas, Peeters, Petra H., Khaw, Kay Thee, Wareham, Nicholas J., Schmidt, Julie A., Aune, Dagfinn, Byrnes, Graham, Scalbert, Augustin, Agudo, Antonio, and Rinaldi, Sabina

Published
2019

44. Assessment of Lung Cancer Risk on the Basis of a Biomarker Panel of Circulating Proteins

Author

Guida, Florence, Sun, Nan, Bantis, Leonidas E., Muller, David C., Li, Peng, Taguchi, Ayumu, Dhillon, Dilsher, Kundnani, Deepali L., Patel, Nikul J., Yan, Qingxiang, Byrnes, Graham, Moons, Karel G. M., Tjonneland, Anne, Panico, Salvatore, Agnoli, Claudia, Vineis, Paolo, Palli, Domenico, Bueno-de-Mesquita, Bas, Peeters, Petra H., Agudo, Antonio, Huerta, Jose M., Dorronsoro, Miren, Rodriguez Barranco, Miguel, Ardanaz, Eva, Travis, Ruth C., Byme, Karl Smith, Boeing, Heiner, Steffen, Annika, Kaaks, Rudolf, Huesing, Anika, Trichopoulou, Antonia, Lagiou, Pagona, La Vecchia, Carlo, Severi, Gianluca, Boutron-Ruault, Marie-Christine, Sandanger, Torkjel M., Weiderpass, Elisabete, Nost, Therese H., Tsilidis, Kostas, Riboli, Elio, Grankvist, Kjell, Johansson, Mikael, Goodman, Gary E., Feng, Ziding, Brennan, Paul, Johansson, Mattias, Hanash, Samir M., Guida, Florence, Sun, Nan, Bantis, Leonidas E., Muller, David C., Li, Peng, Taguchi, Ayumu, Dhillon, Dilsher, Kundnani, Deepali L., Patel, Nikul J., Yan, Qingxiang, Byrnes, Graham, Moons, Karel G. M., Tjonneland, Anne, Panico, Salvatore, Agnoli, Claudia, Vineis, Paolo, Palli, Domenico, Bueno-de-Mesquita, Bas, Peeters, Petra H., Agudo, Antonio, Huerta, Jose M., Dorronsoro, Miren, Rodriguez Barranco, Miguel, Ardanaz, Eva, Travis, Ruth C., Byme, Karl Smith, Boeing, Heiner, Steffen, Annika, Kaaks, Rudolf, Huesing, Anika, Trichopoulou, Antonia, Lagiou, Pagona, La Vecchia, Carlo, Severi, Gianluca, Boutron-Ruault, Marie-Christine, Sandanger, Torkjel M., Weiderpass, Elisabete, Nost, Therese H., Tsilidis, Kostas, Riboli, Elio, Grankvist, Kjell, Johansson, Mikael, Goodman, Gary E., Feng, Ziding, Brennan, Paul, Johansson, Mattias, and Hanash, Samir M.

Abstract

Importance There is an urgent need to improve lung cancer risk assessment because current screening criteria miss a large proportion of cases. Objective To investigate whether a lung cancer risk prediction model based on a panel of selected circulating protein biomarkers can outperform a traditional risk prediction model and current US screening criteria. Design, Setting, and Participants Prediagnostic samples from 108 ever-smoking patients with lung cancer diagnosed within 1 year after blood collection and samples from 216 smoking-matched controls from the Carotene and Retinol Efficacy Trial (CARET) cohort were used to develop a biomarker risk score based on 4 proteins (cancer antigen 125 [CA125], carcinoembryonic antigen [CEA], cytokeratin-19 fragment [CYFRA 21-1], and the precursor form of surfactant protein B [Pro-SFTPB]). The biomarker score was subsequently validated blindly using absolute risk estimates among 63 ever-smoking patients with lung cancer diagnosed within 1 year after blood collection and 90 matched controls from 2 large European population-based cohorts, the European Prospective Investigation into Cancer and Nutrition (EPIC) and the Northern Sweden Health and Disease Study (NSHDS). Main Outcomes and Measures Model validity in discriminating between future lung cancer cases and controls. Discrimination estimates were weighted to reflect the background populations of EPIC and NSHDS validation studies (area under the receiver-operating characteristics curve [AUC], sensitivity, and specificity). Results In the validation study of 63 ever-smoking patients with lung cancer and 90 matched controls (mean [SD] age, 57.7 [8.7] years; 68.6% men) from EPIC and NSHDS, an integrated risk prediction model that combined smoking exposure with the biomarker score yielded an AUC of 0.83 (95% CI, 0.76-0.90) compared with 0.73 (95% CI, 0.64-0.82) for a model based on smoking exposure alone (P = .003 for difference in AUC). At an overall specificity of 0.83, base, En rättelse har publicerats. DOI: 10.1001/jamaoncol.2018.4576.A correction has been published. DOI: 10.1001/jamaoncol.2018.4576.

Published
2018
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45. Assessment of Lung Cancer Risk on the Basis of a Biomarker Panel of Circulating Proteins

Author

Epi Methoden, Child Health, Cancer, Circulatory Health, JC onderzoeksprogramma Methodologie, MS MDL 1, Epi Kanker Team 1, JC onderzoeksprogramma Kanker, Guida, Florence, Sun, Nan, Bantis, Leonidas E, Muller, David C, Li, Peng, Taguchi, Ayumu, Dhillon, Dilsher, Kundnani, Deepali L, Patel, Nikul J, Yan, Qingxiang, Byrnes, Graham, Moons, Karel G M, Tjønneland, Anne, Panico, Salvatore, Agnoli, Claudia, Vineis, Paolo, Palli, Domenico, Bueno-de-Mesquita, Bas, Peeters, Petra H, Agudo, Antonio, Huerta, Jose M, Dorronsoro, Miren, Barranco, Miguel Rodriguez, Ardanaz, Eva, Travis, Ruth C, Byrne, Karl Smith, Boeing, Heiner, Steffen, Annika, Kaaks, Rudolf, Hüsing, Anika, Trichopoulou, Antonia, Lagiou, Pagona, La Vecchia, Carlo, Severi, Gianluca, Boutron-Ruault, Marie-Christine, Sandanger, Torkjel M, Weiderpass, Elisabete, Nøst, Therese H, Tsilidis, Kostas, Riboli, Elio, Grankvist, Kjell, Johansson, Mikael, Goodman, Gary E, Feng, Ziding, Brennan, Paul, Johansson, Mattias, Hanash, Samir M, Integrative Analysis of Lung Cancer Etiology and Risk (INTEGRAL) Consortium for Early Detection of Lung Cancer, Epi Methoden, Child Health, Cancer, Circulatory Health, JC onderzoeksprogramma Methodologie, MS MDL 1, Epi Kanker Team 1, JC onderzoeksprogramma Kanker, Guida, Florence, Sun, Nan, Bantis, Leonidas E, Muller, David C, Li, Peng, Taguchi, Ayumu, Dhillon, Dilsher, Kundnani, Deepali L, Patel, Nikul J, Yan, Qingxiang, Byrnes, Graham, Moons, Karel G M, Tjønneland, Anne, Panico, Salvatore, Agnoli, Claudia, Vineis, Paolo, Palli, Domenico, Bueno-de-Mesquita, Bas, Peeters, Petra H, Agudo, Antonio, Huerta, Jose M, Dorronsoro, Miren, Barranco, Miguel Rodriguez, Ardanaz, Eva, Travis, Ruth C, Byrne, Karl Smith, Boeing, Heiner, Steffen, Annika, Kaaks, Rudolf, Hüsing, Anika, Trichopoulou, Antonia, Lagiou, Pagona, La Vecchia, Carlo, Severi, Gianluca, Boutron-Ruault, Marie-Christine, Sandanger, Torkjel M, Weiderpass, Elisabete, Nøst, Therese H, Tsilidis, Kostas, Riboli, Elio, Grankvist, Kjell, Johansson, Mikael, Goodman, Gary E, Feng, Ziding, Brennan, Paul, Johansson, Mattias, Hanash, Samir M, and Integrative Analysis of Lung Cancer Etiology and Risk (INTEGRAL) Consortium for Early Detection of Lung Cancer

Published
2018

46. Perception of social value predicts participation in school-based research

Author

Pound, Bernadette, Riddell, Michaela, Byrnes, Graham, and Kelly, Heath

Subjects
Public health -- Research, Public schools -- Social policy, Vaccination -- Research, Health surveys -- Social aspects, Health
Abstract

Objective: To investigate factors affecting the participation of schools in a serosurvey. Methods: A telephone interview was conducted with a representative of 80 schools (response rate 92%). The schools had been randomly selected to participate in a seroprevalence survey evaluating a measles vaccination campaign of Victorian school-aged children in 1998. Results: Univariate analysis suggested that responses to the interview were not influenced by school level (primary/ secondary), geographic location, funding source or participation in the seroprevalence survey. There was, however, a strong association of participation in the seroprevalence survey with the perception of value to students and the value to the community. Factor analysis identified two issues: the societal value and practical issues, which explained most of the variance in participation (pseudo R = 0.84). Conclusion: The perception of the benefits of the study strongly influenced the decision by school representatives to participate in the seroprevalence survey. Implications: Recruitment of schools for health-related research may be improved if the number of research projects in schools is monitored and possibly restricted, and the social value of the research is emphasised.

Published
2000

47. Additional file 2: Figure S1. of Unique DNA methylation signature in HPV-positive head and neck squamous cell carcinomas

Author

Esposti, Davide Degli, Sklias, Athena, Lima, Sheila, StĂŠphanie Beghelli-De La Forest Divonne, Cahais, Vincent, Fernandez-Jimenez, Nora, Cros, Marie-Pierre, Ecsedi, Szilvia, Cuenin, Cyrille, Liacine Bouaoun, Byrnes, Graham, Accardi, Rosita, Sudaka, Anne, ValĂŠrie Giordanengo, Hernandez-Vargas, Hector, Pinto, Luis, Obberghen-Schilling, Ellen Van, and Herceg, Zdenko

Abstract

MDS plots and differentially stratified methylation analysis. Figure S2. HNSCCs clustering by organ and by top 50 DMRs. (PPTX 1324Â kb) (PPTX 1324Â kb)

Published
2017
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48. A Case-Control Study to Test the Use of ctDNA in the Early Detection of SCLC Reveals TP53 Mutations in Non-Cancer Controls

Author

Fernandez-Cuesta, Lynnette Perdomo, Sandra Avogbe, Patrice and Leblay, Noemie Delhomme, Tiffany Gaborieau, Valerie and Abedi-Ardekani, Behnoush Chanudet, Estelle Olivier, Magali and Zaridze, David Mukeria, Anush Vilensky, Marta Holcatova, Ivana Polesel, Jerry Simonato, Lorenzo Canova, Cristina and Lagiou, Pagona Brambilla, Christian Brambilla, Elisabeth and Byrnes, Graham Scelo, Ghislaine Le Calvez-Kelm, Florence Fo, Matthieu Mckay, James Brennan, Paul

Published
2017

49. Additional file 1: of Unique DNA methylation signature in HPV-positive head and neck squamous cell carcinomas

Author

Esposti, Davide Degli, Sklias, Athena, Lima, Sheila, StĂŠphanie Beghelli-De La Forest Divonne, Cahais, Vincent, Fernandez-Jimenez, Nora, Cros, Marie-Pierre, Ecsedi, Szilvia, Cuenin, Cyrille, Liacine Bouaoun, Byrnes, Graham, Accardi, Rosita, Sudaka, Anne, ValĂŠrie Giordanengo, Hernandez-Vargas, Hector, Pinto, Luis, Obberghen-Schilling, Ellen Van, and Herceg, Zdenko

Abstract

Model optimization. (PPTX 1128Â kb)

Published
2017
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50. Additional file 9: of Unique DNA methylation signature in HPV-positive head and neck squamous cell carcinomas

Author

Esposti, Davide Degli, Sklias, Athena, Lima, Sheila, StĂŠphanie Beghelli-De La Forest Divonne, Cahais, Vincent, Fernandez-Jimenez, Nora, Cros, Marie-Pierre, Ecsedi, Szilvia, Cuenin, Cyrille, Liacine Bouaoun, Byrnes, Graham, Accardi, Rosita, Sudaka, Anne, ValĂŠrie Giordanengo, Hernandez-Vargas, Hector, Pinto, Luis, Obberghen-Schilling, Ellen Van, and Herceg, Zdenko

Abstract

Co-methylation analysis. (PPTX 3382Â kb)

Published
2017
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