13 results on '"Buxo M"'
Search Results
2. Silibinin and SARS-CoV-2: Dual Targeting of Host Cytokine Storm and Virus Replication Machinery for Clinical Management of COVID-19 Patients
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Bosch-Barrera J, Martin-Castillo B, Buxo M, Brunet J, Encinar J, and Menendez J
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IL-6 ,senescence ,cytokine storm ,coronavirus ,remdesivir ,stat3 ,JAK - Abstract
COVID-19, the illness caused by infection with the novel coronavirus SARS-CoV-2, is a rapidly spreading global pandemic in urgent need of effective treatments. Here we present a comprehensive examination of the host- and virus-targeted functions of the flavonolignan silibinin, a potential drug candidate against COVID-19/SARS-CoV-2. As a direct inhibitor of STAT3-a master checkpoint regulator of inflammatory cytokine signaling and immune response-silibinin might be expected to phenotypically integrate the mechanisms of action of IL-6-targeted monoclonal antibodies and pan-JAK1/2 inhibitors to limit the cytokine storm and T-cell lymphopenia in the clinical setting of severe COVID-19. As a computationally predicted, remdesivir-like inhibitor of RNA-dependent RNA polymerase (RdRp)-the central component of the replication/transcription machinery of SARS-CoV-2-silibinin is expected to reduce viral load and impede delayed interferon responses. The dual ability of silibinin to target both the host cytokine storm and the virus replication machinery provides a strong rationale for the clinical testing of silibinin against the COVID-19 global public health emergency. A randomized, open-label, phase II multicentric clinical trial (SIL-COVID19) will evaluate the therapeutic efficacy of silibinin in the prevention of acute respiratory distress syndrome in moderate-to-severe COVID-19-positive onco-hematological patients at the Catalan Institute of Oncology in Catalonia, Spain.
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- 2020
3. A teaching project on rectal cancer and concentration of procedures: a comparison of oncological results between Catalonia and the rest of autonomous communities
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Codina-Cazador, A, Biondo, S, Espin-Basany, E, Enriquez-Navascues, JM, Garcia-Granero, E, Roig-Vila, JV, Buxo, M, and Spanish Assoc Surg AEC
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Proyecto Vikingo ,Local recurrence ,Overall survival ,Plan Director de Oncologia ,Rectal cancer ,Metastasis - Abstract
Introduction: the goal of this study was to compare the oncological results (local recurrence, metastasis and overall survival) obtained by the Proyecto Docente del Cancer de Recto of the Spanish Association of Surgeons (AEC) (Proyecto Vikingo, PV) in Catalonia versus the rest of Spanish autonomous communities. Methods: the PV database includes 4,508 patients who underwent a curative resection between March 2006 and December 2010, from the first 59 hospitals included in PV; 1,163 were from Catalonia and 3,345 were from the rest of Spain. There was a minimum follow-up of five years. Results: in Catalonia, the five-year cumulative incidence was 8% (95% CI: 6.4-9.9) for local recurrence, 17.7% (95% CI: 15.420.2) for metastasis and 75% (95% CI: 72.4-77.7) for overall survival. In the rest of autonomous communities, these figures were 7% (95% CI: 6.2-8.2) for local recurrence, 22.3% (95% CI: 20.7-23.9) for metastasis, and 71% (95% CI: 69.4-72.9) for overall survival. Variables associated with tumor recurrence in PV included Hartmann's procedure, intraoperative perforation and circumferential margin involvement. Conclusion: the results obtained by the Proyecto Docente del Cancer de Recto were homogeneous between Catalonia and the rest of the autonomous communities.
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- 2019
4. P-237 Percentage of residual fibrosis versus Rubbia-Brandt classification as predictors of overall survival in metastatic colorectal cancer. Which is better?
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Hernández-Yagüe, X., Ortiz-Duran, R., Lopez-Ben, S., Meléndez-Muñoz, C., Buxó, M., Llavata, L., Castro-Gutiérrez, E., Falgueras-Verdaguer, L., Fuertes-Negro, B., Brunet-Vidal, J., and Figueras-Felip, J.
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- 2022
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5. P-252 Residual fibrosis after treatment with anti-epidermal growth factor receptor or bevacizumab in colorectal liver metastases and its correlation with survival: A retrospective pooled analysis
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Hernández-Yagüe, X., Lopez-Ben, S., Llavata, L., Mateu Esquerda, G., Casellas-Robert, M., Ortiz-Duran, R., Buxó, M., Albiol-Quer, M., Meléndez-Muñoz, C., Brunet-Vidal, J., and Figueras-Felip, J.
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- 2021
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6. Oncological results of the educational Rectal Cancer Project in Spain 10 years after its implementation
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Codina Cazador A, Biondo, S, Espin Basany E, Enriquez-Navascues, JM, Garcia-Granero, E, Roig Vila JV, and Buxo, M
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Local recurrence ,Overall survival ,Rectal cancer ,Metastases - Abstract
Introduction: The objective of this observational, prospective, multicenter and multilevel study was to evaluate the oncological outcomes (local recurrence, metastasis and overall survival) of the Rectal Cancer Project of the Spanish Association of Surgeons (AEC) 10 years after its initiation, comparing the results with Scandinavian registries. Methods: The AEC teaching project database includes 17,620 patients to date, of which 4,508 were operated on with a potentially curative resection between March 2006 and December 2010. All of them come from the first 59 hospitals included in the project, and therefore followed for at least 5 years, and are the subject of the present study. Results: The cumulative incidence of local recurrence was 7.3 (95% CI: 8.2-6.5), metastasis 21.0 (CI 95%: 22.4-19.7) and overall survival 72.3 (CI 95%: 80.3-77.6). The multilevel regression analysis with the hospital variable as a random effect, showed a significant variation among the hospitals for the cancer outcome variables: general survival, local recurrence and metastasis (delta 2 = 0.053). Conclusions: This study indicates that the results observed in the AEC' Rectal Cancer Project are inferior than those observed in the Scandinavian registries that we tried to emulate and that this is attributable to the variability of practice in some centers. (C) 2017 AEC. Published by Elsevier Espana, S.L.U. All rights reserved.
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- 2017
7. ANALYSIS OF THE RISK OF THROMBOSIS IN PATIENTS WITH CHRONIC MYELOPROLIFERATIVE NEOPLASMS AND MUTATION OF THE JAK2 AND MPL GENES
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Sagues, M, Xicoy, B, Estrada, N, Zamora, L, Buxo, M, Bustins, A, Diaz, J, Coll, R, Guardia, R, Cruz, D, Moret, C, Roncero, JM, Gonzalez, Y, Santos, N, Blanco, A, Kelleher, N, Lloveras, N, Mostacedo, S, Buch, J, Costa, P, Tejerina, P, Marull, A, Serrando, M, Tuset, E, and Gallardo, D
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- 2017
8. STUDY ON THROMBOSIS, HEMORRHAGE AND MORTALITY OF CHRONIC MYELOPROLIFERATIVE NEOPLASMS: EXPERIENCES OF TWO CENTERS
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Sagues, M, Zamora, L, Xicoy, B, Estrada, N, Bustins, A, Diaz, J, Cruz, D, Moret, C, Costa, P, Buxo, M, Tejerina, P, Marull, A, Serrando, M, Roncero, JM, Gonzalez, Y, Santos, N, Blanco, A, Kelleher, N, Lloveras, N, Mostacedo, S, Coll, R, Guardia, R, Buch, J, Tuset, E, and Gallardo, D
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- 2017
9. Time trends of cancer incidence and mortality in Catalonia during 1993-2007
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Medicina i Cirurgia, Universitat Rovira i Virgili, Ribes, J, Gispert, R, Izquierdo, A, Puigdefabregas, A, Buxo, M, Carulla, M, Freitas, A, Marcos-Gragera, R, Borras, J, Esteban, L, Cleries, R, GALCERAN PADRÓS, JAUME JOSEP MARIA, BORRAS BALADA, JOAN LLUÍS, Medicina i Cirurgia, Universitat Rovira i Virgili, Ribes, J, Gispert, R, Izquierdo, A, Puigdefabregas, A, Buxo, M, Carulla, M, Freitas, A, Marcos-Gragera, R, Borras, J, Esteban, L, Cleries, R, GALCERAN PADRÓS, JAUME JOSEP MARIA, and BORRAS BALADA, JOAN LLUÍS
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To describe time trends of cancer in Catalonia, Spain, during the period 1993-2007.Data have been provided by two population-based cancer registries, Girona and Tarragona, and the Catalan mortality registry. Cancer incidence in Catalonia has been estimated through modeling methods using data from these health structures.During 2003-2007, there were 20,042 cancer cases and 9,842 deaths per year among men and 13,673 new cancer cases and 5,882 deaths among women. The most frequent incident cancers among men were prostate (N = 4,258), lung (N = 3,021), colorectal (N = 3,007) and bladder (N = 2,238), whereas among women they were breast (N = 3,907), colorectal (N = 2,088), corpus uteri (N = 734) and lung (N = 527). During 1993-2007, age-standardized incidence rates (ASIRs) rose 1.2 % per year among men [prostate (6.3 %), testis (5.7 %), kidney (2.9 %), liver (2.2 %) and colorectal (2.1 %)]. ASIRs decreased for stomach (-2.9 %), oral cavity and pharynx (-2.8 %), larynx (-2.7 %) and esophagus (-2 %). Among women, ASIRs only rose for lung (5.2 %), kidney (3.1 %), oral cavity and pharynx (2.6 %) and thyroid (1.6 %). ASIRs decreased for corpus uteri (-2.3 %), stomach (-1.7 %) and ovary (-1.6 %). Cancer mortality decreased -1.3 % per year among men and -2.1 % among women during the same period.Among men, the decrease of incidence/mortality of tobacco-related tumors was related to a reduction of smoking prevalence. Among women, the stabilization of breast cancer incidence and the rise of lung cancer incidence are similar to that observed in most European regions. These results allow assessing the effectiveness of public health strategies and they pose new frontiers for cancer control in Catalonia.
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- 2014
10. Cancer incidence and mortality projections up to 2020 in Catalonia by means of Bayesian models
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Medicina i Cirurgia, Universitat Rovira i Virgili, Borras, J. M., Izquierdo, A., Freitas, A., Buxo, M., Puigdefabregas, A., Borras, J., Vilardell, M. L., Ameijide, A., Gispert, R., Marcos-Gragera, R., Galceran, J., Cleries, R., Esteban, L., Ribes, J., Medicina i Cirurgia, Universitat Rovira i Virgili, Borras, J. M., Izquierdo, A., Freitas, A., Buxo, M., Puigdefabregas, A., Borras, J., Vilardell, M. L., Ameijide, A., Gispert, R., Marcos-Gragera, R., Galceran, J., Cleries, R., Esteban, L., and Ribes, J.
- Abstract
To predict the burden of cancer in Catalonia by 2020 assessing changes in demography and cancer risk during 2010-2020.Data were obtained from Tarragona and Girona cancer registries and Catalan mortality registry. Population age distribution was obtained from the Catalan Institute of Statistics. Predicted cases in Catalonia were estimated through autoregressive Bayesian age-period-cohort models.There will be diagnosed 26,455 incident cases among men and 18,345 among women during 2020, which means an increase of 22.5 and 24.5 % comparing with the cancer incidence figures of 2010. In men, the increase of cases (22.5 %) can be partitioned in three components: 12 % due to ageing, 8 % due to increase in population size and 2 % due to cancer risk. In women, the role of each component was 9, 8 and 8 %, respectively. The increased risk is mainly expected to be observed in tobacco-related tumours among women and in colorectal and liver cancers among men. During 2010-2020 a mortality decline is expected in both sexes.The expected increase of cancer incidence, mainly due to tobacco-related tumours in women and colorectal in men, reinforces the need to strengthen smoking prevention and the expansion of early detection of colorectal cancer in Catalonia.
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- 2014
11. Abstract P4-09-10: Prospective Analysis of Fatty Acid Synthase (FASN) in Breast Cancer Tissue of Early-Stage Breast Cancer Patients
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Puig, T, primary, Blancafort, A, additional, Casoliva, G, additional, Oliveras, G, additional, Casas, M, additional, Buxo, M, additional, Saiz, E, additional, Viñas, G, additional, Dorca, J, additional, and Porta, R, additional
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- 2012
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12. Prospective Analysis of Fatty Acid Synthase (FASN) in Breast Cancer Tissue of Early-Stage Breast Cancer Patients.
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Puig, T., Blancafort, A., Casoliva, G., Oliveras, G., Casas, M., Buxo, M., Saiz, E., Viñas, G., Dorca, J., and Porta, R.
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CANCER cells , *FATTY acid synthases , *TUMORS , *METASTASIS , *NEOVASCULARIZATION , *FATTY acid synthesis , *BREAST cancer patients - Abstract
Background: Cancer cells require nutrients to survive in the unfavorable microenvironment of primary solid tumors or metastases before angiogenesis development. Fatty acid synthase (FASN) is a multi-enzyme protein that catalyzes fatty acid synthesis. Expression levels of FASN are low or undetectable in normal human tissues except for the liver and the adipose tissue. In contrast, high levels of FASN expression have been detected in breast cancer tumors and other human carcinomas. Several reports highlight that FASN overexpression in tumor samples correlates with progression, aggressiveness and metastatic potential of the disease. In addition, some studies have suggested the same correlation with serum levels of FASN. Our aim was to analyze the association between the expression of tumor and serum levels of FASN with clinical and pathological prognostic factors in early-stage breast cancer patients. Methods: Fifty-five patients with early-stage breast cancer treated with surgery and postoperative chemotherapy were included in the study. We prospectively measured the levels of FASN in tumor and serum samples. Clinical data included demographic characteristics, menarche, pregnancy, breast feeding, menopausal status and body mass index (BMI). Pathological and molecular data included: pathological state, histological grade, estrogen and progesterone receptors, HER2 status, p53 mutation and Ki 67 levels. FASN tissue expression levels were determined by IHC and circulating FASN levels were determined by ELISA. FASN expression was graded from 0 to 3+, meaning 0--1+ normal amounts of FASN protein compared to non-tumor breast tissue, 2+ moderate amounts and 3+ the highest levels of FASN expression. Baseline characteristics were summarized descriptively. Categorical variables were compared by c² or Fisher's exact. For continuous variables, if the data are approximately normal, the two groups were compared using ANOVA. If the normality assumption is not warranted, then the Kruskall-Wallis test has been used. Results: Median age was 49 (rage 33-77). 51% of the patients were menopausal and median BMI was 24,75. Thirty-four percent of the patients had stage I, 51% stage II and 15% stage III. We observed a statistically significant association between FASN over expression and the lack of progesterone receptors (p = 0.027) in tumor samples. In contrast, we found no relation between FASN and estrogen receptor nor between FASN and HER2 tumor expression in this setting. Menopause and age were strongly related to higher levels of FASN tumor expression (p < 0.001). Patients with higher BMI had higher levels of FASN in tumor tissue although this association was not statistically significant (p = 0.07). Finally, we observed a positive relation between breast cancer stage and the levels of FASN tumor (p = 0.05). In contrast, circulating FASN levels were not associated with any pathological or clinical prognostic factor. Conclusions: Our study suggests that FASN overexpression is significantly related to age, menopausal status, more advanced stages and lack of progesterone receptor expression in early-stage breast cancer patients. However, no relation between serum levels of FASN and the clinical or molecular prognostic factors have been observed. [ABSTRACT FROM AUTHOR]
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- 2012
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13. Decreased TLR3 in Hyperplastic Adipose Tissue, Blood and Inflamed Adipocytes is Related to Metabolic Inflammation.
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Latorre J, Moreno-Navarrete JM, Sabater M, Buxo M, Rodriguez-Hermosa JI, Girones J, Fort JM, Vilallonga R, Ricart W, Simo R, Fernandez-Real JM, and Ortega FJ
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- Adipocytes metabolism, Adipose Tissue metabolism, Adult, Bariatric Surgery, Cross-Sectional Studies, Female, Humans, Inflammation blood, Inflammation pathology, Male, Middle Aged, Obesity blood, Obesity pathology, Obesity surgery, Toll-Like Receptor 3 blood, Adipocytes pathology, Adipose Tissue pathology, Inflammation genetics, Obesity genetics, Toll-Like Receptor 3 analysis, Toll-Like Receptor 3 genetics, Transcriptome
- Abstract
Background/aims: Obesity is characterized by the immune activation that eventually dampens insulin sensitivity and changes metabolism. This study explores the impact of different inflammatory/ anti-inflammatory paradigms on the expression of toll-like receptors (TLR) found in adipocyte cultures, adipose tissue, and blood., Methods: We evaluated by real time PCR the impact of acute surgery stress in vivo (adipose tissue) and macrophages (MCM) in vitro (adipocytes). Weight loss was chosen as an anti-inflammatory model, so TLR were analyzed in fat samples collected before and after bariatric surgery-induced weight loss. Associations with inflammatory and metabolic parameters were analyzed in non-obese and obese subjects, in parallel with gene expression measures taken in blood and isolated adipocytes/ stromal-vascular cells (SVC). Treatments with an agonist of TLR3 were conducted in human adipocyte cultures under normal conditions and upon conditions that simulated the chronic low-grade inflammatory state of obesity., Results: Surgery stress raised TLR1 and TLR8 in subcutaneous (SAT), and TLR2 in SAT and visceral (VAT) adipose tissue, while decreasing VAT TLR3 and TLR4. MCM led to increased TLR2 and diminished TLR3, TLR4, and TLR5 expressions in human adipocytes. The anti-inflammatory impact of weight loss was concomitant with decreased TLR1, TLR3, and TLR8 in SAT. Cross-sectional associations confirmed increased V/ SAT TLR1 and TLR8, and decreased TLR3 in obese patients, as compared with non-obese subjects. As expected, TLR were predominant in SVC and adipocyte precursor cells, even though expression of all of them but TLR8 (very low levels) was also found in ex vivo isolated and in vitro differentiated adipocytes. Among SVC, CD14+ macrophages showed increased TLR1, TLR2, and TLR7, but decreased TLR3 mRNA. The opposite patterns shown for TLR2 and TLR3 in V/ SAT, SVC, and inflamed adipocytes were observed in blood as well, being TLR3 more likely linked to lymphocyte instead of neutrophil counts. On the other hand, decreased TLR3 in adipocytes challenged with MCM dampened lipogenesis and the inflammatory response to Poly(I:C)., Conclusion: Functional variations in the expression of TLR found in blood and hypertrophied fat depots, namely decreased TLR3 in lymphocytes and inflamed adipocytes, are linked to metabolic inflammation., (© 2018 The Author(s). Published by S. Karger AG, Basel.)
- Published
- 2018
- Full Text
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