1. Excessive anticoagulation in patients with mild renal insufficiency receiving long-term therapeutic enoxaparin.
- Author
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Busby LT, Weyman A, and Rodgers GM
- Subjects
- Adult, Anticoagulants administration & dosage, Anticoagulants adverse effects, Creatine blood, Drug Monitoring, Enoxaparin pharmacokinetics, Female, Hemorrhage chemically induced, Heparin, Low-Molecular-Weight adverse effects, Heparin, Low-Molecular-Weight pharmacokinetics, Humans, Thrombosis complications, Thrombosis drug therapy, Enoxaparin adverse effects, Renal Insufficiency chemically induced
- Abstract
Low-molecular-weight heparins, such as enoxaparin, are increasingly being used for treatment of venous thromboembolism. We describe two patients who received therapeutic enoxaparin for several months. Although their serum creatinine values were normal, both had mild renal insufficiency (creatinine clearance 60-70 ml/min), and both accumulated the drug abnormally and experienced clinical bleeding. These results suggest that patients receiving enoxaparin (or other low-molecular-weight heparins) in therapeutic doses for periods of more than 4 weeks should be considered for laboratory monitoring to avoid bleeding., (Copyright 2001 Wiley-Liss, Inc.)
- Published
- 2001
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