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Byline: CHLOE SCHAMA ALEX JHAMB BURNS MARLEY MARIUS TAYLOR ANTRIM LIAM HESS Love Letters Family and romantic affairs are at the core of fall's best new books. Susie Boyt's Loved [...]

"Hannah Peterson's film 'The Graduates' explores the impact of gun violence on high school students in suburban Utah following a school shooting. The story follows Genevieve, Ben, and John as they navigate grief, survivor's guilt, and the everyday struggles of teenage life. The film, which features age-appropriate casting and a realistic portrayal of teenagers, emphasizes the need for young people to share their perspectives on issues like gun violence. Director Peterson avoids sensationalizing the topic, instead allowing space for the characters to process their emotions and experiences." [Extracted from the article]

Withdrawalof progestational support for pregnancy is part of the final common pathways for parturition, but the role of nuclear progesterone receptor (PGR) isoforms in this process is not known. To determine if the PGR-B isoform participates in cervical remodeling at term, cervices were obtained from mice lacking PGR-B (PGR-BKO) and from wild-type (WT) controls before or after birth. PGR-BKO mice gave birth to viable pups at the same time as WT controls during the early morning of Day 19 postbreeding. Morphological analyses indicated that by the day before birth, cervices from PGR-BKO and WT mice had increased in size, with fewer cell nuclei/area as well as diminished collagen content and structure, as evidenced by optical density of picrosirius red-stained sections, compared to cervices from nonpregnant mice. Moreover, increased numbers of resident macrophages, but not neutrophils, were found in the prepartum cervix of PGR-BKO compared to nonpregnant mice, parallel to findings in WT mice. These results suggest that PGR-B does not contribute to the growth or degradation of the extracellular matrix or proinflammatory processes associated with recruitment of macrophages in the cervix leading up to birth. Rather, other receptors may contribute to the progesterone-dependent mechanism that promotes remodeling of the cervix during pregnancy and in the proinflammatory process associated with ripening before parturition.