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I. INTRODUCTION The US Internal Revenue Service (IRS) possesses invaluable data from individual income tax returns that could vastly expand our understanding of how tax policies affect behavior and how [...], Tax data are invaluable for research, but privacy concerns severely limit access. Although the US Internal Revenue Service produces a public-use file (PUF). improved technology and the proliferation of individual data have made it increasingly difficult to protect. Synthetic data are an alternative that reproduce the statistical properties of administrative data without revealing individual taxpayer information. This paper evaluates the quality and safety of the first fully synthetic PUF and demonstrates its performance in tax model microsimulations. The synthetic PUF could also be used to develop and debug statistical programs that could then be safely run on confidential data via a validation server. Keywords: synthetic data, privacy, individual income taxes, validation server JEL Codes: C15. C18. H24

Germline SAMD9 and SAMD9L mutations cause a spectrum of multisystem disorders that carry a markedly increased risk of developing myeloid malignancies with somatic monosomy 7. Here, we describe 16 siblings, the majority of which were phenotypically normal, from 5 families diagnosed with myelodysplasia and leukemia syndrome with monosomy 7 (MLSM7; OMIM 252270) who primarily had onset of hematologic abnormalities during the first decade of life. Molecular analyses uncovered germline SAMD9L (n = 4) or SAMD9 (n = 1) mutations in these families. Affected individuals had a highly variable clinical course that ranged from mild and transient dyspoietic changes in the bone marrow to a rapid progression of myelodysplastic syndrome (MDS) or acute myeloid leukemia (AML) with monosomy 7. Expression of these gain-of-function SAMD9 and SAMD9L mutations reduces cell cycle progression, and deep sequencing demonstrated selective pressure favoring the outgrowth of clones that have either lost the mutant allele or acquired revertant mutations. The myeloid malignancies of affected siblings acquired cooperating mutations in genes that are also altered in sporadic cases of AML characterized by monosomy 7. These data have implications for understanding how SAMD9 and SAMD9L mutations contribute to myeloid transformation and for recognizing, counseling, and treating affected families.

By the end of 2010, the fair market values for Individual Retirement Arrangements (IRAs) had recovered from their precipitous decline in 2008 to reach levels higher than their previous peak [...]

The year-end fair market value of all Individual Retirement Arrangements (IRAs) fell from $4.7 trillion in 2007 to $3.7 trillion in 2008, a 22.5 percent decrease. While the overwhelming majority [...]

For 2004, individual income taxpayers contributed approximately $48.7 billion to Individual Retirement Arrangements (IRAs). In addition, $214.9 billion were reported as rollovers into IRAs for 2004, usually from employer-sponsored plans [...]

An identification of four breakpoint combination by fluorescence in situ hybridization mapping of 40 cases of inv (2) (p11.2q13) of European origin was done. Result show majority arose independently in different ancestors and a minority either has been transmitted from a common founder or have different breakpoints at the molecular cytogenetic level.

For 2002, individual income taxpayers contributed approximately $42.3 billion to Individual Retirement Arrangements (IRAs). This represented an 18.3-percent increase over the contributions for 2001. In addition, $204.4 billion came into [...]

By combining individual tax returns (Form 1040) and information returns (such as Forms W-2 and 5498) in one panel database, the Statistics of Income (SOI) Division has made it possible [...]

Myelodysplastic syndromes (MDS) are uncommon in children and have a poor prognosis. In contrast to adult MDS, little is known about the genomic landscape of pediatric MDS. Here, we describe the somatic and germline changes of pediatric MDS using whole exome sequencing, targeted amplicon sequencing, and/or RNA-sequencing of 46 pediatric primary MDS patients. Our data show that, in contrast to adult MDS, Ras/MAPK pathway mutations are common in pediatric MDS (45% of primary cohort), while mutations in RNA splicing genes are rare (2% of primary cohort). Surprisingly, germline variants in SAMD9 or SAMD9L were present in 17% of primary MDS patients, and these variants were routinely lost in the tumor cells by chromosomal deletions (e.g., monosomy 7) or copy number neutral loss of heterozygosity (CN-LOH). Our data confirm that adult and pediatric MDS are separate diseases with disparate mechanisms, and that SAMD9/SAMD9L mutations represent a new class of MDS predisposition. [ABSTRACT FROM AUTHOR]

In 1987, the Statistics of Income (SOI) Program began a major new project called the 1987-Based Family Panel. It followed taxpayers selected for our 1987 cross-sectional sample for 10 years. [...]