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5. Comparison between bicarbonate-based and Stewart methods to assess metabolic acid-base disorders in internistic patients. A pilot study

Author

Bruno Francesca, Bruno Cosimo Marcello, Demma Shirin, and Valenti Maria

Subjects
medicine.medical_specialty, Bicarbonate, Significant difference, Metabolic alkalosis, Anion gap, Metabolic acidosis, medicine.disease, Gastroenterology, chemistry.chemical_compound, chemistry, Internal medicine, Cohort, medicine, Chi-square test, Acid-base disorders, Mathematics
Abstract

Aim: To assess the acid-base status in a cohort of internistic patients, using traditional and “modern” methods, to compare their different sensitivity to detect metabolic disorders and to evaluate a possible relationship between classical and alternative parameters.Patients and Methods: 143 assessment of acid-base and electrolytes balance on 121 internistic patients (76 males and 45 females, mean age 73.9 ± 10,8 years) were examined according to bicarbonate-based and Stewart methods.Results: The traditional method detected 81 cases (56.6 %) of metabolic alkalosis and 15 cases (10.4 %) of metabolic acidosis. The Stewart method detected 92 cases (64.3 %) of metabolic alkalosis and 22 cases (15.3%) of metabolic acidosis.Traditional method failed to detect 11 cases of metabolic alkalosis (chi square = 1.443; p = 0.226), and 7 cases of metabolic acidosis (chi square = 1.118; p = 0.290) when compared to Stewart's method. A significant relationship was observed between Strong Ion Gap (SIG) and Anion Gap corrected for albumin concentration (AGcorr) (r= 0.53; p

Published
2017
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10. Acid-Base Disorders in Patients with Chronic Obstructive Pulmonary Disease: A Pathophysiological Review

Author

Bruno, Cosimo Marcello and Valenti, Maria

Subjects
Article Subject
Abstract

The authors describe the pathophysiological mechanisms leading to development of acidosis in patients with chronic obstructive pulmonary disease and its deleterious effects on outcome and mortality rate. Renal compensatory adjustments consequent to acidosis are also described in detail with emphasis on differences between acute and chronic respiratory acidosis. Mixed acid-base disturbances due to comorbidity and side effects of some drugs in these patients are also examined, and practical considerations for a correct diagnosis are provided.

Published
2012
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44. Ferro e ferrodeplezione nell'epatite cronica HCV-correlata

Author

Bertino, Gaetano, Ardiri, Am, Sciuto, M, Ierna, D, Bruno, Cosimo Marcello, Valenti, M, Fisichella, Alfredo, Boemi, Pm, Urso, G, Interlandi, D, Puglisi, M, Santonocito, Mm, DI PRIMA, P, Calvagno, G. S., Pulvirenti, D, and Neri, Sergio

Published
2006

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