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6. Cancer detection in clinical practice and using blood‐based liquid biopsy: A retrospective audit of over 350 dogs

Author

Flory, Andi, primary, McLennan, Lisa, additional, Peet, Betsy, additional, Kroll, Marissa, additional, Stuart, Deirdre, additional, Brown, Devon, additional, Stuebner, Kathy, additional, Phillips, Brenda, additional, Coomber, Brenda L., additional, Woods, J. Paul, additional, Miller, Mairin, additional, Tripp, Chelsea D., additional, Wolf‐Ringwall, Amber, additional, Kruglyak, Kristina M., additional, McCleary‐Wheeler, Angela L., additional, Phelps‐Dunn, Ashley, additional, Wong, Lilian K., additional, Warren, Chelsea D., additional, Brandstetter, Gina, additional, Rosentel, Michelle C., additional, DiMarzio, Lauren R., additional, O'Kell, Allison L., additional, Cohen, Todd A., additional, Grosu, Daniel S., additional, Chibuk, Jason, additional, Tsui, Dana W. Y., additional, Chorny, Ilya, additional, and Rafalko, Jill M., additional

Published
2023
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7. Validation of single‐gene noninvasive prenatal testing for sickle cell disease

Author

Westin, Erik R., primary, Tsao, David S., additional, Atay, Oguzhan, additional, Landry, Brian P., additional, Ye, Patrick P., additional, Chandler‐Brown, Devon, additional, Alford, Brian, additional, Hoskovec, Jennifer, additional, Subramaniam, Akila, additional, Pawlik, Kevin M., additional, Kuper, Spencer G., additional, Goldman, Frederick D., additional, Townes, Tim M., additional, and Sheehan, Vivien A., additional

Published
2022
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9. Tips To Write A Perfect Annotated Bibliography

Author

Brown, Devon

Subjects
perfect annotated bibliography, GeneralLiterature_REFERENCE(e.g.,dictionaries,encyclopedias,glossaries)
Abstract

Are you in the process of writing a good assignment or dissertation that will help you get good marks or applause? Well, the best tip that you need today is to not write a regular bibliography and instead go for the annotated bibliography. If you have been someone who always asked friends and parents questions like to help me with essays andwrite my essay, you may be in a messy situation right now. But, in this article, we will provide you with tips to write a perfect annotated bibliography. Thus, instead of asking your friends, “help me with essays,” you can now give them advice about how to write a perfect annotated bibliography. Follow these tips For Perfect Annotated Bibliography: Summarize the source The first towards writing an annotated bibliography is to summarize the sources you have used while completing the assignment. You can summarize your sources easily by taking down notes or by pointing out major highlights of the sources. Citations Citations are a necessity when someone asks you to “write my essay” or bibliography. It basically means references that are taken from books and other scholarly sources. These are the references that will help you to support your argument. Annotated bibliography The best part about an annotated bibliography is that it is easy to read, and it also helps the readers to know what sources they are going to check for different references. Thus, if you want to make the task easier for the reader, writing annotated bibliography can be a good idea to follow. List of the central theme It is also important to make a list of central themes that focuses on your writing. The list of central themes will give a brief overview of the reader about your writing and the goal and idea behind the writing piece you submitted. In addition to this, you have to explain to your reader why you have written certain points and why you have used a particular reference. Thus, the list of central themes will help your reader to understand the topic in a better way. Evaluate sources It is very important to make a critical evaluation of each source that you have used in your writing. If there are any tests and devices used, you need to include the list in your writing. Let the reader know if you have added value to the research work or not. In addition to this, also add the chronology of the book used. It is important to write if the book you have used is current or outdated. Conclusion An annotated bibliography will help you to become a better writer and researcher. Thus, the next time when you have to complete research and writing on time, you want to ask your friends and family members questions like “Help me with an assignment.” you will know all details, descriptions, and tips needed to write a good quality essay. Finding good sources and writing a research paper takes time. But, if you follow the annotated bibliography, you will be able to convince the reader about your research work. Original Source:https://www.valdezlink.com/perfect-annotated-bibliography

Published
2021
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14. DOCK8 regulates lymphocyte shape integrity for skin antiviral immunity

Author

Zhang, Qian, primary, Dove, Christopher G., additional, Hor, Jyh Liang, additional, Murdock, Heardley M., additional, Strauss-Albee, Dara M., additional, Garcia, Jordan A., additional, Mandl, Judith N., additional, Grodick, Rachael A., additional, Jing, Huie, additional, Chandler-Brown, Devon B., additional, Lenardo, Timothy E., additional, Crawford, Greg, additional, Matthews, Helen, additional, Freeman, Alexandra F., additional, Cornall, Richard J., additional, Germain, Ronald N., additional, Mueller, Scott N., additional, and Su, Helen C., additional

Published
2014
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15. The lived experience of family-centred care by primary caregivers of critically ill children in the pediatric intensive care unit

Author

McClement, Susan (Nursing) Veroukis, Stasa (Pediatrics), Woodgate, Roberta (Nursing), Brown, Devon, McClement, Susan (Nursing) Veroukis, Stasa (Pediatrics), Woodgate, Roberta (Nursing), and Brown, Devon

Abstract

The unexpected admission of a child to the pediatric intensive care unit (PICU) creates feelings of uncertainty, distress, and fear and is a devastating experience for primary caregivers. Health care providers must address primary caregivers` concerns to enhance primary caregivers’ coping abilities. While a family-centred approach to care can assist in diminishing uneasy feelings experienced by primary caregivers, this philosophy of care is not consistently used in everyday practice. The PICU is a unique area of care that focuses on restoring the health of critically ill children with the use of machines and equipment. However, the use of technology for life sustaining measures creates additional responsibilities for health care providers, potentially compromising the quality of patient care. There is evidence to support that the involvement of the primary caregiver in the care of the critically child can address the gap that commonly exists between technology and holistic patient care. Furthermore, involvement in care increases primary caregivers’ satisfaction with the care their child receives and may also improve patient outcomes. Most importantly, the involvement of primary caregivers in the care of the critically ill child encompasses a family-centred approach to care. By increasing health care provider’s awareness of family-centred care within the PICU, primary caregiver’s needs may be more effectively addressed during this devastating and vulnerable time. Health care providers are key players in the promotion of family-centred care in the PICU; however, they are often faced with multiple challenges and barriers. Increasing health care providers’ awareness around the components of family-centred care can facilitate its implementation into practice by understanding how primary care givers define and experience ii family-centred care. Accordingly, a qualitative study guided by the philosophy of hermeneutic phenomenology was conducted to elicit a detailed descrip

Published
2012

19. DOCK8 regulates lymphocyte shape integrity for skin antiviral immunity

Author

Zhang, Qian, Dove, Christopher G., Hor, Jyh Liang, Murdock, Heardley M., Strauss-Albee, Dara M., Garcia, Jordan A., Mandl, Judith N., Grodick, Rachael A., Jing, Huie, Chandler-Brown, Devon B., Lenardo, Timothy E., Crawford, Greg, Matthews, Helen F., Freeman, Alexandra F., Cornall, Richard J., Germain, Ronald N., Mueller, Scott N., and Su, Helen C.

Abstract

DOCK8 mutations result in an inherited combined immunodeficiency characterized by increased susceptibility to skin and other infections. We show that when DOCK8-deficient T and NK cells migrate through confined spaces, they develop cell shape and nuclear deformation abnormalities that do not impair chemotaxis but contribute to a distinct form of catastrophic cell death we term cytothripsis. Such defects arise during lymphocyte migration in collagen-dense tissues when DOCK8, through CDC42 and p21-activated kinase (PAK), is unavailable to coordinate cytoskeletal structures. Cytothripsis of DOCK8-deficient cells prevents the generation of long-lived skin-resident memory CD8 T cells, which in turn impairs control of herpesvirus skin infections. Our results establish that DOCK8-regulated shape integrity of lymphocytes prevents cytothripsis and promotes antiviral immunity in the skin.

Published
2014
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25. PP2A Cdc55 dephosphorylates Pds1 and inhibits spindle elongation in S. cerevisiae .

Author

Khondker S, Kajjo S, Chandler-Brown D, Skotheim J, Rudner A, and Ikui AE

Subjects
Cell Cycle Proteins genetics, Cell Cycle Proteins metabolism, Chromosome Segregation, Nuclear Proteins genetics, Nuclear Proteins metabolism, Phosphorylation, Protein Phosphatase 2 genetics, Protein Phosphatase 2 metabolism, Protein Serine-Threonine Kinases genetics, Protein-Tyrosine Kinases, Securin, Separase, Spindle Apparatus metabolism, Saccharomyces cerevisiae genetics, Saccharomyces cerevisiae metabolism, Saccharomyces cerevisiae Proteins genetics, Saccharomyces cerevisiae Proteins metabolism
Abstract

PP2A Cdc55 (the form of protein phosphatase 2A containing Cdc55) regulates cell cycle progression by reversing cyclin-dependent kinase (CDK)- and polo-like kinase (Cdc5)-dependent phosphorylation events. In S. cerevisiae , Cdk1 phosphorylates securin (Pds1), which facilitates Pds1 binding and inhibits separase (Esp1). During anaphase, Esp1 cleaves the cohesin subunit Scc1 and promotes spindle elongation. Here, we show that PP2A Cdc55 directly dephosphorylates Pds1 both in vivo and in vitro Pds1 hyperphosphorylation in a cdc55 deletion mutant enhanced the Pds1-Esp1 interaction, which played a positive role in Pds1 nuclear accumulation and in spindle elongation. We also show that nuclear PP2A Cdc55 plays a role during replication stress to inhibit spindle elongation. This pathway acted independently of the known Mec1, Swe1 or spindle assembly checkpoint (SAC) checkpoint pathways. We propose a model where Pds1 dephosphorylation by PP2A Cdc55 disrupts the Pds1-Esp1 protein interaction and inhibits Pds1 nuclear accumulation, which prevents spindle elongation, a process that is elevated during replication stress., Competing Interests: Competing interestsThe authors declare no competing or financial interests., (© 2020. Published by The Company of Biologists Ltd.)

Published
2020
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