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1. Fast Dose Calculation for Stereotactic Synchrotron Radiotherapy

Author

Freud, N, Letang, J, Mary, C, Boudou, C, Ferrero, C, Elleaume, H, Bravin, A, Esteve, F, Babot, D, Freud N, Letang JM, Mary C, Boudou C, Ferrero C, Elleaume H, Bravin A, Esteve F, Babot D, Freud, N, Letang, J, Mary, C, Boudou, C, Ferrero, C, Elleaume, H, Bravin, A, Esteve, F, Babot, D, Freud N, Letang JM, Mary C, Boudou C, Ferrero C, Elleaume H, Bravin A, Esteve F, and Babot D

Abstract

A hybrid approach is proposed to compute the dose deposited in cancerous and healthy tissues during stereotactic synchrotron radiotherapy treatment. In this approach the computation is divided into two parts: (1) the primary dose is calculated using a deterministic algorithm based on ray casting; (2) the secondary dose (due to scattering and fluorescence) is computed using a hybrid algorithm combining Monte Carlo and a deterministic method. The results obtained for test cases are compared to those obtained with the Monte Carlo method alone (Geant4 code) and found to be in excellent agreement. The proposed simulation scheme makes it possible to simulate dose maps with a single personal computer, with computation time and statistical fluctuations substantially reduced in comparison with conventional Monte Carlo simulations. © 2007 IEEE.

Published
2007

2. Synchrotron radiation computed tomography station at the ESRF biomedical beamline

Author

Choi, JY, Rah, S, Nemoz, C, Bayat, S, Berruyer, G, Brochard, T, Coan, P, Le Duc, G, Keyrilainen, J, Monfraix, S, Renier, M, Requardt, H, Bravin, A, Tafforeau, P, Adam, J, Biston, M, Boudou, C, Charvet, A, Corde, S, Elleaume, H, Esteve, F, Joubert, A, Rousseau, J, Tropres, I, Fernandez, M, Porra, L, Suortti, P, Fiedler, S, Thomlinson, W, Nemoz C., Bayat S., Berruyer G., Brochard T., Coan P., Le Duc G., Keyrilainen J., Monfraix S., Renier M., Requardt H., Bravin A, Tafforeau P., Adam J. F., Biston M. C., Boudou C., Charvet A. M., Corde S., Elleaume H., Esteve F., Joubert A., Rousseau J., Tropres I., Fernandez M., Porra L., Suortti P., Fiedler S., Thomlinson W, Choi, JY, Rah, S, Nemoz, C, Bayat, S, Berruyer, G, Brochard, T, Coan, P, Le Duc, G, Keyrilainen, J, Monfraix, S, Renier, M, Requardt, H, Bravin, A, Tafforeau, P, Adam, J, Biston, M, Boudou, C, Charvet, A, Corde, S, Elleaume, H, Esteve, F, Joubert, A, Rousseau, J, Tropres, I, Fernandez, M, Porra, L, Suortti, P, Fiedler, S, Thomlinson, W, Nemoz C., Bayat S., Berruyer G., Brochard T., Coan P., Le Duc G., Keyrilainen J., Monfraix S., Renier M., Requardt H., Bravin A, Tafforeau P., Adam J. F., Biston M. C., Boudou C., Charvet A. M., Corde S., Elleaume H., Esteve F., Joubert A., Rousseau J., Tropres I., Fernandez M., Porra L., Suortti P., Fiedler S., and Thomlinson W

Abstract

The different tomography imaging modalities of the ESRF Medical Beamline are described and research applications are presented.

Published
2007

3. A hybrid approach for fast simulation of dose deposition in stereotactic synchrotron radiotherapy

Author

Freud, N, Letang Jean, M, Mary, C, Boudou, C, Ferrero, C, Elleaume, H, Bravin, A, Esteve, F, Babot, D, Freud Nicolas, Letang Jean Michel, Mary Corentin, Boudou Caroline, Ferrero Claudio, Elleaume Helene, Bravin A, Esteve Francois, Babot Daniel, Freud, N, Letang Jean, M, Mary, C, Boudou, C, Ferrero, C, Elleaume, H, Bravin, A, Esteve, F, Babot, D, Freud Nicolas, Letang Jean Michel, Mary Corentin, Boudou Caroline, Ferrero Claudio, Elleaume Helene, Bravin A, Esteve Francois, and Babot Daniel

Abstract

A hybrid approach was developed to compute the dose deposited in cancerous and healthy tissues during stereotactic synchrotron radiation therapy treatment. The proposed approach divides the computation into two parts: (1) the dose deposited by primary radiation (coming directly from the incident X-ray beam) is calculated using a deterministic algorithm based on ray casting, optimized for transport in voxelized geometries; (2) the dose deposited by secondary radiation (Rayleigh and Compton scattering, fluorescence) is computed using a hybrid algorithm combining Monte Carlo and deterministic calculations. In the Monte Carlo part, a set of scattering and fluorescence events occurring in the patient is determined. These events are further processed in a deterministic way, which considerably improves the statistics of the final dose map. The results obtained in test cases are compared to those obtained with the Monte Carlo method alone (Geant4 and MCNPX codes) and found to be in excellent agreement. The proposed simulation scheme makes it possible to simulate dose maps with a single PC, featuring computation time and statistical fluctuations substantially reduced in comparison with full Monte Carlo simulations.

Published
2008

4. Synchrotron radiation computed tomography station at the ESRF biomedical beamline

Author

Nemoz, C, Bayat, S, Berruyer, G, Brochard, T, Coan, P, Le Duc, G, Keyrilainen, J, Monfraix, S, Renier, M, Requardt, H, Bravin, A, Tafforeau, P, Adam, J F, Biston, M C, Boudou, C, Charvet, A M, corde, s, Elleaume, H, Esteve, F, Joubert, A, Rousseau, J, Tropres, I, Fernandez, M, Porra, L, Suortti, P, Fiedler, S, Thomlinson, W, Nemoz, C, Bayat, S, Berruyer, G, Brochard, T, Coan, P, Le Duc, G, Keyrilainen, J, Monfraix, S, Renier, M, Requardt, H, Bravin, A, Tafforeau, P, Adam, J F, Biston, M C, Boudou, C, Charvet, A M, corde, s, Elleaume, H, Esteve, F, Joubert, A, Rousseau, J, Tropres, I, Fernandez, M, Porra, L, Suortti, P, Fiedler, S, and Thomlinson, W

Abstract

The different tomography imaging modalities of the ESRF Medical Beamline are described and research applications are presented

Published
2007

5. Dosimetry for synchrotron stereotactic radiotherapy: fricke gel and Monte Carlo calculations

Author

Boudou, C, Biston, M-C, corde, s, Adam, J-F, Joubert, A, Charvet, A-M, Nemoz, C, Ferrero, C, Esteve, F, Elleaume, H, Boudou, C, Biston, M-C, corde, s, Adam, J-F, Joubert, A, Charvet, A-M, Nemoz, C, Ferrero, C, Esteve, F, and Elleaume, H

Abstract

In Synchrotron stereotactic radiotherapy (SSR) the tumor is loaded with atoms ofhigh atomic number (Z) element, and exposed to monochromatic X-rays from a synchrotron source (50-100 keV), in stereotactic conditions. This method is under investigation at the European Synchrotron Radiation Facility (ESRF) for the treatment of brain tumors. Conventional treatment planning systems are not suitable for SSR since the beam energy, the irradiation geometry and the presence ofhigh Z elements differ from commercial systems. Therefore, SSR requires the development of new procedures for the evaluation of dose maps. Monte Carlo (MC) method offers the potential of calculating the dose in complicated geometries, made ofheterogeneous materials. MC calculations were performed using the MCNP4C general purpose code. Gel dosimetry allows accurate experimental verification ofthree-dimensional absorbed dose distributions from any irradiation geometries. In this study, the Fricke chemical dosimeter was employed for it is easy to prepare without special facilities. Various phantoms filled with Fricke gel were irradiated in SSR configuration. The dose profiles obtained were compared with MC simulations.

Published
2005

6. Fricke dosimetry for synchrotron stereotactic radiotherapy

Author

Boudou, C, Biston, M C, Adam, J F, Joubert, A, corde, s, Charvet, A M, Esteve, F, Elleaume, H, Boudou, C, Biston, M C, Adam, J F, Joubert, A, corde, s, Charvet, A M, Esteve, F, and Elleaume, H

Abstract

In synchrotron stereotactic radiotherapy (SSR) the tumor is loaded with a high Z element, and exposed to monochromatic x-rays from a synchrotron source, in stereotactic conditions. The SSR treatment efficiency is related to the heavy element concentration achievable in the tumor, to the radiation energy, and the irradiation geometry [1,2]. The experimental dose verification of SSR in three dimensions with a good spatial resolution is highly desirable for radiotherapy [3]. In this study, Fricke dosimeter and Monte Carlo calculations were employed for assessing 2D dose distribution.

Published
2004

8. Horizonte Humanista e Fenomenologia na Geografia: o problema da assimilação humanista do pensamento de Martin Heidegger

Author

SANTOS, J. M., BOUDOU, C. J., FREIRE, A. L. O., and REIS, L. C. T. D.

Abstract

Made available in DSpace on 2018-08-01T23:45:51Z (GMT). No. of bitstreams: 1 tese_11510_Dissertação Josimar Monteiro20180406-93909.pdf: 1243835 bytes, checksum: 98e14ea445aaf4bc3436ebbd800c8f50 (MD5) Previous issue date: 2017-12-08 Resumo da dissertação: A pesquisa proposta se estabelece pela relação entre dois elementos básicos, por um lado o horizonte humanista na Geografia e, por outro lado, a fenomenologia. A articulação desses elementos na pesquisa proposta se dá através da problematização da leitura humanista dispensada ao pensamento de Heidegger no horizonte humanista da ciência geográfica. O objetivo geral da pesquisa consiste em ratificar que o pensamento de Heidegger é frontalmente incompatível com qualquer modalidade de Humanismo - a despeito do fato da própria constituição da Geografia humanista, na década de 1970, tenha se desenvolvido através da filiação à fenomenologia, destacando-se, nesse contexto, a referência expressa à obra de Heidegger. Esse objetivo se justifica quando se observa o estado da arte atual sobre o assunto na disciplina, na medida em que, não obstante a referida incompatibilidade já tenha sido trazida à tona no debate interno da ciência geográfica, de modo patente, desde meados da década de 1980, a requisição ao pensamento de Heidegger como matriz fenomenológica para a perspectiva humanista permaneceu se reproduzindo nas décadas subsequentes, como atestam publicações recentes que incidem na filiação ao filósofo para fomentar a perspectiva humanista na geografia. Trata-se de uma leitura particularmente recorrente nos rumos que, sobretudo a partir da década de 1990, se desenvolveu na pesquisa brasileira vinculada à Geografia humanista. Pretende-se, desse modo, contribuir à pesquisa geográfica sobre o assunto, evidenciando que a leitura humanista do filósofo tende a obstruir o propósito primordial que deveria conduzir a relação entre uma ciência particular, no caso a Geografia, e o pensamento de Heidegger, a saber: reabilitar a investigação sobre a fundamentação ontológica da respectiva ciência. Isso implicaria a necessidade do geógrafo assumir, antes de tudo, a analítica do ser-aí (exposta de modo paradigmático em Ser e Tempo) como fio condutor à investigação ontológica através da fenomenologia-hermenêutica de Heidegger, na medida em a referida analítica constitui, para o filósofo, a fonte da ontologia fundamental de onde todas as ontologias derivariam.

Published
2017

9. Synchrotron radiation computed tomography station at the ESRF biomedical beamline

Author

William Thomlinson, Paul Tafforeau, Thierry Brochard, I. Tropres, H. Elleaume, Jean-François Adam, Herwig Requardt, Christian Nemoz, S. Monfraix, G. Le Duc, Alberto Bravin, Pekka Suortti, François Estève, Sam Bayat, Jani Keyriläinen, G. Berruyer, Marie-Claude Biston, Julia Rousseau, Stéphanie Corde, Manuel Fernández, Liisa Porra, S. Fiedler, Aurélie Joubert, A. M. Charvet, Paola Coan, Michel Renier, Caroline Boudou, Choi, JY, Rah, S, Nemoz, C, Bayat, S, Berruyer, G, Brochard, T, Coan, P, Le Duc, G, Keyrilainen, J, Monfraix, S, Renier, M, Requardt, H, Bravin, A, Tafforeau, P, Adam, J, Biston, M, Boudou, C, Charvet, A, Corde, S, Elleaume, H, Esteve, F, Joubert, A, Rousseau, J, Tropres, I, Fernandez, M, Porra, L, Suortti, P, Fiedler, S, and Thomlinson, W

Subjects
medicine.medical_specialty, genetic structures, Synchrotron radiation, FIS/07 - FISICA APPLICATA (A BENI CULTURALI, AMBIENTALI, BIOLOGIA E MEDICINA), Image processing, Computed tomography, Biomedical equipment, urologic and male genital diseases, law.invention, Imaging modalities, Imaging, Optics, law, Medical, otorhinolaryngologic diseases, medicine, Medical physics, Tomography, Physics, medicine.diagnostic_test, business.industry, Synchrotron, Beamline, business, psychological phenomena and processes
Abstract

The different tomography imaging modalities of the ESRF Medical Beamline are described and research applications are presented.

Published
2007

10. Wnt-pathway inhibitors with selective activity against triple-negative breast cancer: From thienopyrimidine to quinazoline inhibitors.

Author

Boudou C, Mattio L, Koval A, Soulard V, and Katanaev VL

Abstract

The Wnt-pathway has a critical role in development and tissue homeostasis and has attracted increased attention to develop anticancer drugs due to its aberrant activation in many cancers. In this study, we identified a novel small molecule series with a thienopyrimidine scaffold acting as a downstream inhibitor of the β-catenin-dependent Wnt-pathway. This novel chemotype was investigated using Wnt-dependent triple-negative breast cancer (TNBC) cell lines. Structure activity relationship (SAR) exploration led to identification of low micromolar compounds such as 5a , 5d , 5e and a novel series with quinazoline scaffold such as 9d . Further investigation showed translation of activity to inhibit cancer survival of HCC1395 and MDA-MB-468 TNBC cell lines without affecting a non-cancerous breast epithelial cell line MCF10a. This anti-proliferative effect was synergistic to docetaxel treatment. Collectively, we identified novel chemotypes acting as a downstream inhibitor of β-catenin-dependent Wnt-pathway that could expand therapeutic options to manage TNBC., Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest., (Copyright © 2022 Boudou, Mattio, Koval, Soulard and Katanaev.)

Published
2022
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11. Enhanced survival and cure of F98 glioma-bearing rats following intracerebral delivery of carboplatin in combination with photon irradiation.

Author

Rousseau J, Boudou C, Barth RF, Balosso J, Estève F, and Elleaume H

Subjects
Animals, Combined Modality Therapy, Glioma mortality, Glioma pathology, Humans, Male, Rats, Rats, Inbred F344, Antineoplastic Agents administration & dosage, Carboplatin administration & dosage, Glioma drug therapy, Photons therapeutic use
Abstract

Purpose: The goal of the present study was to evaluate the efficacy of intracerebral (i.c.) administration of carboplatin by means of convection-enhanced delivery (CED) in combination with fractionated, external beam photon irradiation for the treatment of F98 glioma-bearing rats., Experimental Design: Carboplatin (20 microg/20 microL) was administrated i.c. by CED to F98 glioma-bearing rats, 13 days after stereotactic implantation of 10(3) tumor cells. One day following initiation of CED, a 24-Gy X-ray dose was administered in three daily fractions of 8 Gy each. Photon irradiation was carried out using either a conventional (6 MV) linear accelerator or a monochromatic synchrotron source (80 keV) at the European Synchrotron Radiation Facility. The primary end point of this study was overall survival., Results: The median survival times were 79 and 60 days and the corresponding percent increase in life spans were 182% and 114%, respectively, for the combination of carboplatin chemotherapy and irradiation with either 6-MV or 80-keV photons. A subset of long-term survivors (>200 days) were observed in both chemoradiotherapy groups: 16.6% and 8.3% for 6 MV and 80 keV, respectively. In contrast, the median survival times for 6-MV or 80-keV irradiated controls, chemotherapy alone, and untreated controls were 42, 51, 45, and 28 days, respectively., Conclusions: Our results convincingly show the therapeutic efficacy of i.c. administration of carboplatin by means of CED in combination with either 6-MV or 80-keV photons. Further studies are warranted to optimize this combination of chemoradiotherapy for malignant gliomas.

Published
2007
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12. Trans-(+/-)-2-tert-butyl-3-phenyloxaziridine: a unique reagent for the oxidation of thiolates into sulfenates.

Author

Boudou C, Bergès M, Sagnes C, Sopková-de Oliveira Santos J, Perrio S, and Metzner P

Subjects
Aziridines chemistry, Molecular Structure, Oxidation-Reduction, Sulfenic Acids chemistry, Aziridines chemical synthesis, Sulfenic Acids chemical synthesis, Sulfhydryl Compounds chemistry
Abstract

Aliphatic thiolates were efficiently converted into the corresponding sulfenates by smooth oxidation with trans-(+/-)-2-tert-butyl-3-phenyloxaziridine at room temperature (five examples). Subsequent electrophilic quench with benzyl bromide led to sulfoxides (S-alkylation) in good to moderate yields. Application of the protocol to an aromatic substrate was also successful. This work represents the first valuable example of the use of this poorly active oxidizing agent in synthetic organic chemistry without the need for activating conditions.

Published
2007
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13. Remarkably mild and simple preparation of sulfenate anions from beta-sulfinylesters: a new route to enantioenriched sulfoxides.

Author

Caupène C, Boudou C, Perrio S, and Metzner P

Abstract

[reaction: see text] A general, efficient, and experimentally simple method for the generation of sulfenate salts has been developed using beta-sulfinylesters as substrates. The process is based on a retro-Michael reaction, initiated by deprotonation at low temperature. Upon treatment with alkyl halides, the liberated sulfenates are subsequently converted into sulfoxides in good to excellent yield. Extension of the methodology to an unprecedented access to nonracemic sulfoxides by introduction of an enantiopure ligand, (-)-sparteine, is also described.

Published
2005
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