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Timely forecast of atmospheric pollutants fallout due to accidental fires can provide decision-makers with useful information for effective emergency response, for planning environmental monitoring and for conveying essential alerts to the population to minimize health risks. The SAPERI project (Accelerated simulation of accidental releases in the atmosphere on heterogeneous platforms—from its Italian initials) implements a modeling chain to quickly supply evidence about the dispersion of pollutants accidentally released in the atmosphere, even in the early stages of the emergency when full knowledge of the incident details is missing. The SAPERI modeling chain relies on SPRAY-WEB, a Lagrangian particle dispersion model openly shared for research purposes, parallelized on a GPU to take advantage of local or cloud computing resources and interfaced with open meteorological forecasts made available by the Meteo Italian SupercompuTing PoRtAL (MISTRAL) consortium over Italy. The operational model provides a quantitative and qualitative estimate of the impact of the emergency event by means of a maximum ground level concentration and a footprint map. In this work, the SAPERI modeling chain is tested in a real case event that occurred in Beinasco (Torino, Italy) in December 2021, mimicking its use with limited or missing local input data as occurs when an alert message is first issued. An evaluation of the meteorology forecast is carried out by comparing the wind and temperature fields obtained from MISTRAL with observations from weather stations. The concentrations obtained from the dispersion model are then compared with the observations at three air quality monitoring stations impacted by the event.