13 results on '"Benediktsdottir, Kristrun R"'
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2. Parental origin of sequence variants associated with complex diseases
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Kong, Augustine, Steinthorsdottir, Valgerdur, Masson, Gisli, Thorleifsson, Gudmar, Sulem, Patrick, Besenbacher, Soren, Jonasdottir, Aslaug, Sigurdsson, Asgeir, Kristinsson, Kari Th., Jonasdottir, Adalbjorg, Frigge, Michael L., Gylfason, Arnaldur, Olason, Pall I., Gudjonsson, Sigurjon A., Sverrisson, Sverrir, Stacey, Simon N., Sigurgeirsson, Bardur, Benediktsdottir, Kristrun R., Sigurdsson, Helgi, Jonsson, Thorvaldur, Benediktsson, Rafn, Olafsson, Jon H., Johannsson, Oskar Th., Hreidarsson, Astradur B., Sigurdsson, Gunnar, Ferguson-Smith, Anne C., Gudbjartsson, Daniel F., Thorsteinsdottir, Unnur, and Stefansson, Kari
- Subjects
Genes -- Physiological aspects -- Research -- Genetic aspects ,Single nucleotide polymorphisms -- Research -- Physiological aspects -- Genetic aspects ,Type 2 diabetes -- Genetic aspects -- Risk factors -- Research ,Environmental issues ,Science and technology ,Zoology and wildlife conservation - Abstract
Effects of susceptibility variants may depend on from which parent they are inherited. Although many associations between sequence variants and human traits have been discovered through genome-wide associations, the impact of parental origin has largely been ignored. Here we show that for 38,167 Icelanders genotyped using single nucleotide polymorphism (SNP) chips, the parental origin of most alleles can be determined. For this we used a combination of genealogy and long-range phasing. We then focused on SNPs that associate with diseases and are within 500 kilobases of known imprinted genes. Seven independent SNP associations were examined. Five--one with breast cancer, one with basal-cell carcinoma and three with type 2 diabetes--have parental-origin-specific associations. These variants are located in two genomic regions, 11p15 and 7q32, each harbouring a cluster of imprinted genes. Furthermore, we observed a novel association between the SNP rs2334499 at 11p15 and type 2 diabetes. Here the allele that confers risk when paternally inherited is protective when maternally transmitted. We identified a differentially methylated CTCF-binding site at 11p15 and demonstrated correlation of rs2334499 with decreased methylation of that site., The effect of sequence variants on phenotypes may depend on parental origin. The most obvious scheme, although not the only one (1), is imprinting in which the effect is limited [...]
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- 2009
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3. Insertion of an SVA-E retrotransposon into theCASP8gene is associated with protection against prostate cancer
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Stacey, Simon N., primary, Kehr, Birte, additional, Gudmundsson, Julius, additional, Zink, Florian, additional, Jonasdottir, Aslaug, additional, Gudjonsson, Sigurjon A., additional, Sigurdsson, Asgeir, additional, Halldorsson, Bjarni V., additional, Agnarsson, Bjarni A., additional, Benediktsdottir, Kristrun R., additional, Aben, Katja K.H., additional, Vermeulen, Sita H., additional, Cremers, Ruben G., additional, Panadero, Angeles, additional, Helfand, Brian T., additional, Cooper, Phillip R., additional, Donovan, Jenny L., additional, Hamdy, Freddie C., additional, Jinga, Viorel, additional, Okamoto, Ichiro, additional, Jonasson, Jon G., additional, Tryggvadottir, Laufey, additional, Johannsdottir, Hrefna, additional, Kristinsdottir, Anna M., additional, Masson, Gisli, additional, Magnusson, Olafur T., additional, Iordache, Paul D., additional, Helgason, Agnar, additional, Helgason, Hannes, additional, Sulem, Patrick, additional, Gudbjartsson, Daniel F., additional, Kong, Augustine, additional, Jonsson, Eirikur, additional, Barkardottir, Rosa B., additional, Einarsson, Gudmundur V., additional, Rafnar, Thorunn, additional, Thorsteinsdottir, Unnur, additional, Mates, Ioan N., additional, Neal, David E., additional, Catalona, William J., additional, Mayordomo, José I., additional, Kiemeney, Lambertus A., additional, Thorleifsson, Gudmar, additional, and Stefansson, Kari, additional
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- 2016
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4. New basal cell carcinoma susceptibility loci
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Stacey, Simon N., primary, Helgason, Hannes, additional, Gudjonsson, Sigurjon A., additional, Thorleifsson, Gudmar, additional, Zink, Florian, additional, Sigurdsson, Asgeir, additional, Kehr, Birte, additional, Gudmundsson, Julius, additional, Sulem, Patrick, additional, Sigurgeirsson, Bardur, additional, Benediktsdottir, Kristrun R., additional, Thorisdottir, Kristin, additional, Ragnarsson, Rafn, additional, Fuentelsaz, Victoria, additional, Corredera, Cristina, additional, Gilaberte, Yolanda, additional, Grasa, Matilde, additional, Planelles, Dolores, additional, Sanmartin, Onofre, additional, Rudnai, Peter, additional, Gurzau, Eugene, additional, Koppova, Kvetoslava, additional, Nexø, Bjørn A., additional, Tjønneland, Anne, additional, Overvad, Kim, additional, Jonasson, Jon G., additional, Tryggvadottir, Laufey, additional, Johannsdottir, Hrefna, additional, Kristinsdottir, Anna M., additional, Stefansson, Hreinn, additional, Masson, Gisli, additional, Magnusson, Olafur T., additional, Halldorsson, Bjarni V., additional, Kong, Augustine, additional, Rafnar, Thorunn, additional, Thorsteinsdottir, Unnur, additional, Vogel, Ulla, additional, Kumar, Rajiv, additional, Nagore, Eduardo, additional, Mayordomo, José I., additional, Gudbjartsson, Daniel F., additional, Olafsson, Jon H., additional, and Stefansson, Kari, additional
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- 2015
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5. A germline variant in the TP53 polyadenylation signal confers cancer susceptibility.
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Stacey, Simon N, Sulem, Patrick, Jonasdottir, Aslaug, Masson, Gisli, Gudmundsson, Julius, Gudbjartsson, Daniel F, Magnusson, Olafur T, Gudjonsson, Sigurjon A, Sigurgeirsson, Bardur, Thorisdottir, Kristin, Ragnarsson, Rafn, Benediktsdottir, Kristrun R, Nexø, Bjørn A, Tjønneland, Anne, Overvad, Kim, Rudnai, Peter, Gurzau, Eugene, Koppova, Kvetoslava, Hemminki, Kari, Corredera, Cristina, Fuentelsaz, Victoria, Grasa, Pilar, Navarrete, Sebastian, Fuertes, Fernando, García-Prats, Maria D, Sanambrosio, Enrique, Panadero, Angeles, De Juan, Ana, Garcia, Almudena, Rivera, Fernando, Planelles, Dolores, Soriano, Virtudes, Requena, Celia, Aben, Katja K, van Rossum, Michelle M, Cremers, Ruben G H M, van Oort, Inge M, van Spronsen, Dick-Johan, Schalken, Jack A, Peters, Wilbert H M, Helfand, Brian T, Donovan, Jenny L, Hamdy, Freddie C, Badescu, Daniel, Codreanu, Ovidiu, Jinga, Mariana, Csiki, Irma E, Constantinescu, Vali, Badea, Paula, Mates, Ioan N, Dinu, Daniela E, Constantin, Adrian, Mates, Dana, Kristjansdottir, Sjofn, Agnarsson, Bjarni A, Jonsson, Eirikur, Barkardottir, Rosa B, Einarsson, Gudmundur V, Sigurdsson, Fridbjorn, Moller, Pall H, Stefansson, Tryggvi, Valdimarsson, Trausti, Johannsson, Oskar T, Sigurdsson, Helgi, Jonsson, Thorvaldur, Jonasson, Jon G, Tryggvadottir, Laufey, Rice, Terri, Hansen, Helen M, Xiao, Yuanyuan, Lachance, Daniel H, O Neill, Brian Patrick, Kosel, Matthew L, Decker, Paul A, Thorleifsson, Gudmar, Johannsdottir, Hrefna, Helgadottir, Hafdis T, Sigurdsson, Asgeir, Steinthorsdottir, Valgerdur, Lindblom, Annika, Sandler, Robert S, Keku, Temitope O, Banasik, Karina, Jørgensen, Torben, Witte, Daniel R, Hansen, Torben, Pedersen, Oluf, Jinga, Viorel, Neal, David E, Catalona, William J, Wrensch, Margaret, Wiencke, John, Jenkins, Robert B, Nagore, Eduardo, Vogel, Ulla, Kiemeney, Lambertus A, Kumar, Rajiv, Mayordomo, José I, Olafsson, Jon H, Kong, Augustine, Thorsteinsdottir, Unnur, Rafnar, Thorunn, Stefansson, Kari, Smedh, Kenneth, Stacey, Simon N, Sulem, Patrick, Jonasdottir, Aslaug, Masson, Gisli, Gudmundsson, Julius, Gudbjartsson, Daniel F, Magnusson, Olafur T, Gudjonsson, Sigurjon A, Sigurgeirsson, Bardur, Thorisdottir, Kristin, Ragnarsson, Rafn, Benediktsdottir, Kristrun R, Nexø, Bjørn A, Tjønneland, Anne, Overvad, Kim, Rudnai, Peter, Gurzau, Eugene, Koppova, Kvetoslava, Hemminki, Kari, Corredera, Cristina, Fuentelsaz, Victoria, Grasa, Pilar, Navarrete, Sebastian, Fuertes, Fernando, García-Prats, Maria D, Sanambrosio, Enrique, Panadero, Angeles, De Juan, Ana, Garcia, Almudena, Rivera, Fernando, Planelles, Dolores, Soriano, Virtudes, Requena, Celia, Aben, Katja K, van Rossum, Michelle M, Cremers, Ruben G H M, van Oort, Inge M, van Spronsen, Dick-Johan, Schalken, Jack A, Peters, Wilbert H M, Helfand, Brian T, Donovan, Jenny L, Hamdy, Freddie C, Badescu, Daniel, Codreanu, Ovidiu, Jinga, Mariana, Csiki, Irma E, Constantinescu, Vali, Badea, Paula, Mates, Ioan N, Dinu, Daniela E, Constantin, Adrian, Mates, Dana, Kristjansdottir, Sjofn, Agnarsson, Bjarni A, Jonsson, Eirikur, Barkardottir, Rosa B, Einarsson, Gudmundur V, Sigurdsson, Fridbjorn, Moller, Pall H, Stefansson, Tryggvi, Valdimarsson, Trausti, Johannsson, Oskar T, Sigurdsson, Helgi, Jonsson, Thorvaldur, Jonasson, Jon G, Tryggvadottir, Laufey, Rice, Terri, Hansen, Helen M, Xiao, Yuanyuan, Lachance, Daniel H, O Neill, Brian Patrick, Kosel, Matthew L, Decker, Paul A, Thorleifsson, Gudmar, Johannsdottir, Hrefna, Helgadottir, Hafdis T, Sigurdsson, Asgeir, Steinthorsdottir, Valgerdur, Lindblom, Annika, Sandler, Robert S, Keku, Temitope O, Banasik, Karina, Jørgensen, Torben, Witte, Daniel R, Hansen, Torben, Pedersen, Oluf, Jinga, Viorel, Neal, David E, Catalona, William J, Wrensch, Margaret, Wiencke, John, Jenkins, Robert B, Nagore, Eduardo, Vogel, Ulla, Kiemeney, Lambertus A, Kumar, Rajiv, Mayordomo, José I, Olafsson, Jon H, Kong, Augustine, Thorsteinsdottir, Unnur, Rafnar, Thorunn, Stefansson, Kari, and Smedh, Kenneth
- Abstract
To identify new risk variants for cutaneous basal cell carcinoma, we performed a genome-wide association study of 16 million SNPs identified through whole-genome sequencing of 457 Icelanders. We imputed genotypes for 41,675 Illumina SNP chip-typed Icelanders and their relatives. In the discovery phase, the strongest signal came from rs78378222[C] (odds ratio (OR) = 2.36, P = 5.2 × 10(-17)), which has a frequency of 0.0192 in the Icelandic population. We then confirmed this association in non-Icelandic samples (OR = 1.75, P = 0.0060; overall OR = 2.16, P = 2.2 × 10(-20)). rs78378222 is in the 3' untranslated region of TP53 and changes the AATAAA polyadenylation signal to AATACA, resulting in impaired 3'-end processing of TP53 mRNA. Investigation of other tumor types identified associations of this SNP with prostate cancer (OR = 1.44, P = 2.4 × 10(-6)), glioma (OR = 2.35, P = 1.0 × 10(-5)) and colorectal adenoma (OR = 1.39, P = 1.6 × 10(-4)). However, we observed no effect for breast cancer, a common Li-Fraumeni syndrome tumor (OR = 1.06, P = 0.57, 95% confidence interval 0.88-1.27).
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- 2011
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6. Common sequence variants on 2p15 and Xp11.22 confer susceptibility to prostate cancer.
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Gudmundsson, Julius, Sulem, Patrick, Rafnar, Thorunn, Bergthorsson, Jon T, Manolescu, Andrei, Gudbjartsson, Daniel, Agnarsson, Bjarni A, Sigurdsson, Asgeir, Benediktsdottir, Kristrun R, Blondal, Thorarinn, Jakobsdottir, Margret, Stacey, Simon N, Kostic, Jelena, Kristinsson, Kari T, Birgisdottir, Birgitta, Ghosh, Shyamali, Magnusdottir, Droplaug N, Thorlacius, Steinunn, Thorleifsson, Gudmar, Zheng, S Lilly, Sun, Jielin, Chang, Bao-Li, Elmore, J Bradford, Breyer, Joan P, McReynolds, Kate M, Bradley, Kevin M, Yaspan, Brian L, Wiklund, Fredrik, Stattin, Pär, Lindström, Sara, Adami, Hans-Olov, McDonnell, Shannon K, Schaid, Daniel J, Cunningham, Julie M, Wang, Liang, Cerhan, James R, St Sauver, Jennifer L, Isaacs, Sara D, Wiley, Kathleen E, Partin, Alan W, Walsh, Patrick C, Polo, Sonia, Ruiz-Echarri, Manuel, Navarrete, Sebastian, Fuertes, Fernando, Saez, Berta, Godino, Javier, Weijerman, Philip C, Swinkels, Dorine W, Aben, Katja K, Witjes, J Alfred, Suarez, Brian K, Helfand, Brian T, Frigge, Michael L, Kristjansson, Kristleifur, Ober, Carole, Jonsson, Eirikur, Einarsson, Gudmundur V, Xu, Jianfeng, Gronberg, Henrik, Smith, Jeffrey R, Thibodeau, Stephen N, Isaacs, William B, Catalona, William J, Mayordomo, Jose I, Kiemeney, Lambertus A, Barkardottir, Rosa B, Gulcher, Jeffrey R, Thorsteinsdottir, Unnur, Kong, Augustine, Stefansson, Kari, Gudmundsson, Julius, Sulem, Patrick, Rafnar, Thorunn, Bergthorsson, Jon T, Manolescu, Andrei, Gudbjartsson, Daniel, Agnarsson, Bjarni A, Sigurdsson, Asgeir, Benediktsdottir, Kristrun R, Blondal, Thorarinn, Jakobsdottir, Margret, Stacey, Simon N, Kostic, Jelena, Kristinsson, Kari T, Birgisdottir, Birgitta, Ghosh, Shyamali, Magnusdottir, Droplaug N, Thorlacius, Steinunn, Thorleifsson, Gudmar, Zheng, S Lilly, Sun, Jielin, Chang, Bao-Li, Elmore, J Bradford, Breyer, Joan P, McReynolds, Kate M, Bradley, Kevin M, Yaspan, Brian L, Wiklund, Fredrik, Stattin, Pär, Lindström, Sara, Adami, Hans-Olov, McDonnell, Shannon K, Schaid, Daniel J, Cunningham, Julie M, Wang, Liang, Cerhan, James R, St Sauver, Jennifer L, Isaacs, Sara D, Wiley, Kathleen E, Partin, Alan W, Walsh, Patrick C, Polo, Sonia, Ruiz-Echarri, Manuel, Navarrete, Sebastian, Fuertes, Fernando, Saez, Berta, Godino, Javier, Weijerman, Philip C, Swinkels, Dorine W, Aben, Katja K, Witjes, J Alfred, Suarez, Brian K, Helfand, Brian T, Frigge, Michael L, Kristjansson, Kristleifur, Ober, Carole, Jonsson, Eirikur, Einarsson, Gudmundur V, Xu, Jianfeng, Gronberg, Henrik, Smith, Jeffrey R, Thibodeau, Stephen N, Isaacs, William B, Catalona, William J, Mayordomo, Jose I, Kiemeney, Lambertus A, Barkardottir, Rosa B, Gulcher, Jeffrey R, Thorsteinsdottir, Unnur, Kong, Augustine, and Stefansson, Kari
- Published
- 2008
7. Two variants on chromosome 17 confer prostate cancer risk, and the one in TCF2 protects against type 2 diabetes
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Gudmundsson, Julius, Sulem, Patrick, Steinthorsdottir, Valgerdur, Bergthorsson, Jon T, Thorleifsson, Gudmar, Manolescu, Andrei, Rafnar, Thorunn, Gudbjartsson, Daniel, Agnarsson, Bjarni A, Baker, Adam, Sigurdsson, Asgeir, Benediktsdottir, Kristrun R, Jakobsdottir, Margret, Blondal, Thorarinn, Stacey, Simon N, Helgason, Agnar, Gunnarsdottir, Steinunn, Olafsdottir, Adalheidur, Kristinsson, Kari T, Birgisdottir, Birgitta, Ghosh, Shyamali, Thorlacius, Steinunn, Magnusdottir, Dana, Stefansdottir, Gerdur, Kristjansson, Kristleifur, Bagger, Yu, Wilensky, Robert L, Reilly, Muredach P, Morris, Andrew D, Kimber, Charlotte H, Adeyemo, Adebowale, Chen, Yuanxiu, Zhou, Jie, So, Wing-Yee, Tong, Peter C Y, Ng, Maggie C Y, Hansen, Torben, Andersen, Gitte, Borch-Johnsen, Knut, Jorgensen, Torben, Tres, Alejandro, Fuertes, Fernando, Ruiz-Echarri, Manuel, Asin, Laura, Saez, Berta, van Boven, Erica, Klaver, Siem, Swinkels, Dorine W, Aben, Katja K, Graif, Theresa, Cashy, John, Suarez, Brian K, van Vierssen Trip, Onco, Frigge, Michael L, Ober, Carole, Hofker, Marten H, Wijmenga, Cisca, Christiansen, Claus, Rader, Daniel J, Palmer, Colin N A, Rotimi, Charles, Chan, Juliana C N, Pedersen, Oluf, Sigurdsson, Gunnar, Benediktsson, Rafn, Jonsson, Eirikur, Einarsson, Gudmundur V, Mayordomo, Jose I, Catalona, William J, Kiemeney, Lambertus A, Barkardottir, Rosa B, Gulcher, Jeffrey R, Thorsteinsdottir, Unnur, Kong, Augustine, Stefansson, Kari, Gudmundsson, Julius, Sulem, Patrick, Steinthorsdottir, Valgerdur, Bergthorsson, Jon T, Thorleifsson, Gudmar, Manolescu, Andrei, Rafnar, Thorunn, Gudbjartsson, Daniel, Agnarsson, Bjarni A, Baker, Adam, Sigurdsson, Asgeir, Benediktsdottir, Kristrun R, Jakobsdottir, Margret, Blondal, Thorarinn, Stacey, Simon N, Helgason, Agnar, Gunnarsdottir, Steinunn, Olafsdottir, Adalheidur, Kristinsson, Kari T, Birgisdottir, Birgitta, Ghosh, Shyamali, Thorlacius, Steinunn, Magnusdottir, Dana, Stefansdottir, Gerdur, Kristjansson, Kristleifur, Bagger, Yu, Wilensky, Robert L, Reilly, Muredach P, Morris, Andrew D, Kimber, Charlotte H, Adeyemo, Adebowale, Chen, Yuanxiu, Zhou, Jie, So, Wing-Yee, Tong, Peter C Y, Ng, Maggie C Y, Hansen, Torben, Andersen, Gitte, Borch-Johnsen, Knut, Jorgensen, Torben, Tres, Alejandro, Fuertes, Fernando, Ruiz-Echarri, Manuel, Asin, Laura, Saez, Berta, van Boven, Erica, Klaver, Siem, Swinkels, Dorine W, Aben, Katja K, Graif, Theresa, Cashy, John, Suarez, Brian K, van Vierssen Trip, Onco, Frigge, Michael L, Ober, Carole, Hofker, Marten H, Wijmenga, Cisca, Christiansen, Claus, Rader, Daniel J, Palmer, Colin N A, Rotimi, Charles, Chan, Juliana C N, Pedersen, Oluf, Sigurdsson, Gunnar, Benediktsson, Rafn, Jonsson, Eirikur, Einarsson, Gudmundur V, Mayordomo, Jose I, Catalona, William J, Kiemeney, Lambertus A, Barkardottir, Rosa B, Gulcher, Jeffrey R, Thorsteinsdottir, Unnur, Kong, Augustine, and Stefansson, Kari
- Abstract
We performed a genome-wide association scan to search for sequence variants conferring risk of prostate cancer using 1,501 Icelandic men with prostate cancer and 11,290 controls. Follow-up studies involving three additional case-control groups replicated an association of two variants on chromosome 17 with the disease. These two variants, 33 Mb apart, fall within a region previously implicated by family-based linkage studies on prostate cancer. The risks conferred by these variants are moderate individually (allele odds ratio of about 1.20), but because they are common, their joint population attributable risk is substantial. One of the variants is in TCF2 (HNF1beta), a gene known to be mutated in individuals with maturity-onset diabetes of the young type 5. Results from eight case-control groups, including one West African and one Chinese, demonstrate that this variant confers protection against type 2 diabetes.
- Published
- 2007
8. Insertion of an SVA-E retrotransposon into the CASP8 gene is associated with protection against prostate cancer.
- Author
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Stacey, Simon N., Kehr, Birte, Gudmundsson, Julius, FlorianZink, Jonasdottir, Aslaug, Gudjonsson, Sigurjon A., Sigurdsson, Asgeir, Halldorsson, Bjarni V., Agnarsson, Bjarni A., Benediktsdottir, Kristrun R., Aben, Katja K. H., Vermeulen, Sita H., Cremers, Ruben G., Panadero, Angeles, Helfand, Brian T., Cooper, Phillip R., Donovan, Jenny L., Hamdy, Freddie C., Jinga, Viorel, and Ichiro Okamoto
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- 2016
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9. A common variant associated with prostate cancer in European and African populations
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Amundadottir, Laufey T, Sulem, Patrick, Gudmundsson, Julius, Helgasson, Agnar, Baker, Adam, Agnarsson, Bjarni A, Sigurdsson, Asgeir, Benediktsdottir, Kristrun R, Cazier, Jean-Baptiste, Sainz, Jesus, Jakobsdottir, Margret, Kostic, Jelena, Magnusdottir, Droplaug N, Gosh, Shyamali, Agnarsson, Kari, Birgisdottir, Birgitta, Le Roux, Louise, Olafsdottir, Adalheidur, Blondal, Thorarinn, Andresdottir, Margret, Gretarsdottir, Olafia Svandis, Bergthorsson, Jon T, Gudbjartsson, Daniel, Gylfason, Arnaldur, Thorleifsson, Gudmar, Manolescu, Andrei, Kristjansson, Kristleifur, Geirsson, Gudmundur, Isaksson, Helgi, Douglas, Julie, Johansson, Jan-Erik, Bälter, Katarina, Wiklund, Fredrik, Montie, James E, Yu, Xiaoying, Suarez, Brian K, Ober, Carole, Cooney, Kathleen A, Grönberg, Henrik, Catalona, William J, Einarsson, Gudmundur V, Barkardottir, Rosa B, Gulcher, Jeffrey R, Kong, Augustine, Thorsteinsdottir, Unnur, Stefansson, Kari, Amundadottir, Laufey T, Sulem, Patrick, Gudmundsson, Julius, Helgasson, Agnar, Baker, Adam, Agnarsson, Bjarni A, Sigurdsson, Asgeir, Benediktsdottir, Kristrun R, Cazier, Jean-Baptiste, Sainz, Jesus, Jakobsdottir, Margret, Kostic, Jelena, Magnusdottir, Droplaug N, Gosh, Shyamali, Agnarsson, Kari, Birgisdottir, Birgitta, Le Roux, Louise, Olafsdottir, Adalheidur, Blondal, Thorarinn, Andresdottir, Margret, Gretarsdottir, Olafia Svandis, Bergthorsson, Jon T, Gudbjartsson, Daniel, Gylfason, Arnaldur, Thorleifsson, Gudmar, Manolescu, Andrei, Kristjansson, Kristleifur, Geirsson, Gudmundur, Isaksson, Helgi, Douglas, Julie, Johansson, Jan-Erik, Bälter, Katarina, Wiklund, Fredrik, Montie, James E, Yu, Xiaoying, Suarez, Brian K, Ober, Carole, Cooney, Kathleen A, Grönberg, Henrik, Catalona, William J, Einarsson, Gudmundur V, Barkardottir, Rosa B, Gulcher, Jeffrey R, Kong, Augustine, Thorsteinsdottir, Unnur, and Stefansson, Kari
- Published
- 2006
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10. A common variant associated with prostate cancer in European and African populations
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Amundadottir, Laufey T., Sulem, Patrick, Gudmundsson, Julius, Helgason, Agnar, Baker, Adam, Agnarsson, Bjarni A., Sigurdsson, Asgeir, Benediktsdottir, Kristrun R., Cazier, Jean-Baptiste, Sainz, Jesus, Jakobsdottir, Margret, Kostic, Jelena, Magnusdottir, Droplaug N., Ghosh, Shyamali, Agnarsson, Kari, Birgisdottir, Birgitta, Le Roux, Louise, Olafsdottir, Adalheidur, Blondal, Thorarinn, Andresdottir, Margret, Gretarsdottir, Olafia Svandis, Bergthorsson, Jon T., Gudbjartsson, Daniel, Gylfason, Arnaldur, Thorleifsson, Gudmar, Manolescu, Andrei, Kristjansson, Kristleifur, Geirsson, Gudmundur, Isaksson, Helgi, Douglas, Julie, Johansson, Jan-Erik, Bälter, Katarina, Wiklund, Fredrik, Montie, James E., Yu, Xiaoying, Suarez, Brian K., Ober, Carole, Cooney, Kathleen A., Gronberg, Henrik, Catalona, William J., Einarsson, Gudmundur V., Barkardottir, Rosa B., Gulcher, Jeffrey R., Kong, Augustine, Thorsteinsdottir, Unnur, Stefansson, Kari, Amundadottir, Laufey T., Sulem, Patrick, Gudmundsson, Julius, Helgason, Agnar, Baker, Adam, Agnarsson, Bjarni A., Sigurdsson, Asgeir, Benediktsdottir, Kristrun R., Cazier, Jean-Baptiste, Sainz, Jesus, Jakobsdottir, Margret, Kostic, Jelena, Magnusdottir, Droplaug N., Ghosh, Shyamali, Agnarsson, Kari, Birgisdottir, Birgitta, Le Roux, Louise, Olafsdottir, Adalheidur, Blondal, Thorarinn, Andresdottir, Margret, Gretarsdottir, Olafia Svandis, Bergthorsson, Jon T., Gudbjartsson, Daniel, Gylfason, Arnaldur, Thorleifsson, Gudmar, Manolescu, Andrei, Kristjansson, Kristleifur, Geirsson, Gudmundur, Isaksson, Helgi, Douglas, Julie, Johansson, Jan-Erik, Bälter, Katarina, Wiklund, Fredrik, Montie, James E., Yu, Xiaoying, Suarez, Brian K., Ober, Carole, Cooney, Kathleen A., Gronberg, Henrik, Catalona, William J., Einarsson, Gudmundur V., Barkardottir, Rosa B., Gulcher, Jeffrey R., Kong, Augustine, Thorsteinsdottir, Unnur, and Stefansson, Kari
- Abstract
With the increasing incidence of prostate cancer, identifying common genetic variants that confer risk of the disease is important. Here we report such a variant on chromosome 8q24, a region initially identified through a study of Icelandic families. Allele -8 of the microsatellite DG8S737 was associated with prostate cancer in three case-control series of European ancestry from Iceland, Sweden and the US. The estimated odds ratio (OR) of the allele is 1.62 (P = 2.7 x 10(-11)). About 19% of affected men and 13% of the general population carry at least one copy, yielding a population attributable risk (PAR) of approximately 8%. The association was also replicated in an African American case-control group with a similar OR, in which 41% of affected individuals and 30% of the population are carriers. This leads to a greater estimated PAR (16%) that may contribute to higher incidence of prostate cancer in African American men than in men of European ancestry.
- Published
- 2006
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11. Quantitative DNA perturbations of p53 in endometriosis: analysis of American and Icelandic cases
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Gylfason, Jon Torfi, primary, Dang, Dianne, additional, Petursdottir, Vigdis, additional, Benediktsdottir, Kristrun R., additional, Geirsson, Reynir T., additional, Poindexter, Alfred, additional, Mitchell-Leef, Dorothy, additional, Buster, John E., additional, Carson, Sandra A., additional, Simpson, Joe Leigh, additional, and Bischoff, Farideh Z., additional
- Published
- 2005
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12. Association of Folate-Pathway Gene Polymorphisms with the Risk of Prostate Cancer: a Population-Based Nested Case-Control Study, Systematic Review, and Meta-analysis.
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Collin, Simon M., Metcalfe, Chris, Zuccolo, Luisa, Lewis, Sarah J., Chen, Lina, Cox, Angela, Davis, Michael, Lane, J. Athene, Donovan, Jenny, Smith, George Davey, Neal, David E., Hamdy, Freddie C., Gudmundsson, Julius, Sulem, Patrick, Rafnar, Thorunn, Benediktsdottir, Kristrun R., Eeles, Rosalind A., Guy, Michelle, Kote-Jarai, Zsofia, and Morrison, Jonathan
- Abstract
The article offers a meta-analysis of associations among polymorphisms in the folate metabolic pathway and prostate cancer. It mentions that data from four genome-wide association studies and from a case-control study conducted within the Prostate Testing for Cancer and Treatment study. It mentions that the analysis intends to determine whether the folate metabolic pathway has a role in prostate cancer.
- Published
- 2009
- Full Text
- View/download PDF
13. Analysis of HPC1, HPCX, and PCaP in Icelandic hereditary prostate cancer.
- Author
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Bergthorsson, Jon T., Johannesdottir, Gudrun, Arason, Adalgeir, Benediktsdottir, Kristrun R., Agnarsson, Bjarni A., Bailey-Wilson, Joan E., Gillanders, Elizabeth, Smith, Jeffrey, Trent, Jeff, and Barkardottir, Rosa B.
- Subjects
PROSTATE cancer ,GENETIC disorders ,PROSTATE diseases ,HETEROGENEITY ,GENETICS ,ONCOLOGY - Abstract
Putative prostate cancer susceptibility loci have recently been identified by genetic linkage analysis on chromosomes 1q24–25 (HPC1), 1q44.2–43 (PCaP), and Xq27–28 (HPCX). In order to estimate the genetic linkage in Icelandic prostate cancer families, we genotyped 241 samples from 87 families with eleven markers in the HPC1 region, six markers at PCaP, and eight at HPCX. Concurrently, we assessed allelic imbalance at the HPC1 and PCaP loci in selected tumors from the patients. For each of the candidate regions, the combined parametric and non-parametric LOD scores were strongly negative. Evidence for linkage allowing for genetic heterogeneity was also insignificant for all the regions. The results were negative irrespective of whether calculations were performed for the whole material or for a selected set of early age at onset families. The prevalence of allelic imbalance was relatively low in both the HPC1 (0%–9%) and PCaP (5%–20%) regions and was not elevated in tumors from positively linked families. Our studies indicate that the putative cancer susceptibility genes at chromosomes 1q24–25, 1q44.2–43, and Xq27–28 are unlikely to contribute significantly to hereditary prostate cancer in Iceland and that selective loss of the HPC1 and PCaP loci is a relatively rare somatic event in prostate cancers. [ABSTRACT FROM AUTHOR]
- Published
- 2000
- Full Text
- View/download PDF
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