659 results on '"Beck, Alexander"'
Search Results
2. PD-1 blockade does not improve efficacy of EpCAM-directed CAR T-cell in lung cancer brain metastasis
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Blobner, Jens, Dengler, Laura, Eberle, Constantin, Herold, Julika J., Xu, Tao, Beck, Alexander, Mühlbauer, Anton, Müller, Katharina J., Teske, Nico, Karschnia, Philipp, van den Heuvel, Dominic, Schallerer, Ferdinand, Ishikawa-Ankerhold, Hellen, Thon, Niklas, Tonn, Joerg-Christian, Subklewe, Marion, Kobold, Sebastian, Harter, Patrick N., Buchholz, Veit R., and von Baumgarten, Louisa
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- 2024
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3. On the effect of galactic outflows in cosmological simulations of disc galaxies
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Valentini, Milena, Murante, Giuseppe, Borgani, Stefano, Monaco, Pierluigi, Bressan, Alessandro, and Beck, Alexander M.
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Astrophysics - Astrophysics of Galaxies - Abstract
We investigate the impact of galactic outflow modelling on the formation and evolution of a disc galaxy, by performing a suite of cosmological simulations with zoomed-in initial conditions of a Milky Way-sized halo. We verify how sensitive the general properties of the simulated galaxy are to the way in which stellar feedback triggered outflows are implemented, keeping initial conditions, simulation code and star formation (SF) model all fixed. We present simulations that are based on a version of the GADGET3 code where our sub-resolution model is coupled with an advanced implementation of Smoothed Particle Hydrodynamics that ensures a more accurate fluid sampling and an improved description of gas mixing and hydrodynamical instabilities. We quantify the strong interplay between the adopted hydrodynamic scheme and the sub-resolution model describing SF and feedback. We consider four different galactic outflow models, including the one introduced by Dalla Vecchia and Schaye (2012) and a scheme that is inspired by the Springel and Hernquist (2003) model. We find that the sub-resolution prescriptions adopted to generate galactic outflows are the main shaping factor of the stellar disc component at low redshift. The key requirement that a feedback model must have to be successful in producing a disc-dominated galaxy is the ability to regulate the high-redshift SF (responsible for the formation of the bulge component), the cosmological infall of gas from the large-scale environment, and gas fall-back within the galactic radius at low redshift, in order to avoid a too high SF rate at $z=0$., Comment: Published in MNRAS. Figure 18 is a duplicate of Fig. 12 (left-hand panel) in the published version of the paper, due to an error occurred in the proof editing process. The real Fig. 18 is missing in the published version. This problem is not present here in the arxiv submission. Corrected a few typos to match the published version
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- 2017
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4. nIFTy galaxy cluster simulations V: Investigation of the Cluster Infall Region
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Arthur, Jake, Pearce, Frazer R., Gray, Meghan E., Elahi, Pascal J., Knebe, Alexander, Beck, Alexander M., Cui, Weiguang, Cunnama, Daniel, Davé, Romeel, February, Sean, Huang, Shuiyao, Katz, Neal, Kay, Scott T., McCarthy, Ian G., Murante, Giuseppe, Perret, Valentin, Power, Chris, Puchwein, Ewald, Saro, Alexandro, Sembolini, Federico, Teyssier, Romain, and Yepes, Gustavo
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Astrophysics - Astrophysics of Galaxies - Abstract
We examine the properties of the galaxies and dark matter haloes residing in the cluster infall region surrounding the simulated $\Lambda$CDM galaxy cluster studied by Elahi et al. (2016) at z=0. The $1.1\times10^{15}h^{-1}\text{M}_{\odot}$ galaxy cluster has been simulated with eight different hydrodynamical codes containing a variety of hydrodynamic solvers and subgrid schemes. All models completed a dark-matter only, non-radiative and full-physics run from the same initial conditions. The simulations contain dark matter and gas with mass resolution $m_{\text{DM}}=9.01\times 10^8h^{-1}\text{M}_{\odot}$ and $m_{\text{gas}}=1.9\times 10^8h^{-1}\text{M}_{\odot}$ respectively. We find that the synthetic cluster is surrounded by clear filamentary structures that contain ~60% of haloes in the infall region with mass ~$10^{12.5} - 10^{14} h^{-1}\text{M}_{\odot}$, including 2-3 group-sized haloes ($> 10^{13}h^{-1}\text{M}_{\odot}$). However, we find that only ~10% of objects in the infall region are subhaloes residing in haloes, which may suggest that there is not much ongoing preprocessing occurring in the infall region at z=0. By examining the baryonic content contained within the haloes, we also show that the code-to-code scatter in stellar fraction across all halo masses is typically ~2 orders of magnitude between the two most extreme cases, and this is predominantly due to the differences in subgrid schemes and calibration procedures that each model uses. Models that do not include AGN feedback typically produce too high stellar fractions compared to observations by at least ~1 order of magnitude., Comment: 14 pages, 9 figures, 1 table; accepted for publication in MNRAS
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- 2016
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5. nIFTy Galaxy Cluster simulations IV: Quantifying the Influence of Baryons on Halo Properties
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Cui, Weiguang, Power, Chris, Knebe, Alexander, Kay, Scott T., Sembolini, Federico, Elahi, Pascal J., Yepes, Gustavo, Pearce, Frazer, Cunnama, Daniel, Beck, Alexander M., Vecchia, Claudio Dalla, Davé, Romeel, February, Sean, Huang, Shuiyao, Hobbs, Alex, Katz, Neal, McCarthy, Ian G., Murante, Giuseppe, Perret, Valentin, Puchwein, Ewald, Read, Justin I., Saro, Alexandro, Teyssier, Romain, and Thacker, Robert J.
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Astrophysics - Astrophysics of Galaxies - Abstract
Building on the initial results of the nIFTy simulated galaxy cluster comparison, we compare and contrast the impact of baryonic physics with a single massive galaxy cluster, run with 11 state-of-the-art codes, spanning adaptive mesh, moving mesh, classic and modern SPH approaches. For each code represented we have a dark matter only (DM) and non-radiative (NR) version of the cluster, as well as a full physics (FP) version for a subset of the codes. We compare both radial mass and kinematic profiles, as well as global measures of the cluster (e.g. concentration, spin, shape), in the NR and FP runs with that in the DM runs. Our analysis reveals good consistency (<= 20%) between global properties of the cluster predicted by different codes when integrated quantities are measured within the virial radius R200. However, we see larger differences for quantities within R2500, especially in the FP runs. The radial profiles reveal a diversity, especially in the cluster centre, between the NR runs, which can be understood straightforwardly from the division of codes into classic SPH and non-classic SPH (including the modern SPH, adaptive and moving mesh codes); and between the FP runs, which can also be understood broadly from the division of codes into those that include AGN feedback and those that do not. The variation with respect to the median is much larger in the FP runs with different baryonic physics prescriptions than in the NR runs with different hydrodynamics solvers., Comment: 24 pages, 13 figures, MNRAS submitted
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- 2016
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6. A supernova scenario for magnetic fields and rotation measures in galaxies
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Beck, Alexander M. and Dolag, Klaus
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Astrophysics - Astrophysics of Galaxies ,Astrophysics - Cosmology and Nongalactic Astrophysics - Abstract
We present a model for the seeding and evolution of magnetic fields in galaxies by supernovae (SN). SN explosions during galaxy assembly provide seed fields, which are subsequently amplified by compression, shear flows and random motions. Our model explains the origin of microG magnetic fields within galactic structures. We implement our model in the MHD version of the cosmological simulation code Gadget-3 and couple it with a multi-phase description of the interstellar medium. We perform simulations of Milky Way-like galactic halo formation and analyze the distribution and strength of the magnetic field. We investigate the intrinsic rotation measure (RM) evolution and find RM values exceeding 1000 rad/m*m at high redshifts and RM values around 10 rad/m*m at present-day. We compare our simulations to a limited set of observational data points and find encouraging similarities. In our model, galactic magnetic fields are a natural consequence of the very basic processes of star formation and galaxy assembly., Comment: 2 pages, proceedings of IAU symposium 315
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- 2015
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7. nIFTY galaxy cluster simulations III: The Similarity & Diversity of Galaxies & Subhaloes
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Elahi, Pascal J., Knebe, Alexander, Pearce, Frazer R., Power, Chris, Yepes, Gustavo, Cui, Weiguang, Cunnama, Daniel, Kay, Scott T., Sembolini, Federico, Beck, Alexander M., Davé, Romeel, February, Sean, Huang, Shuiyao, Katz, Neal, McCarthy, Ian G., Murante, Giuseppe, Perret, Valentin, Puchwein, Ewald, Saro, Alexandro, and Teyssier, Romain
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Astrophysics - Astrophysics of Galaxies - Abstract
We examine subhaloes and galaxies residing in a simulated LCDM galaxy cluster ($M^{\rm crit}_{200}=1.1\times10^{15}M_\odot/h$) produced by hydrodynamical codes ranging from classic Smooth Particle Hydrodynamics (SPH), newer SPH codes, adaptive and moving mesh codes. These codes use subgrid models to capture galaxy formation physics. We compare how well these codes reproduce the same subhaloes/galaxies in gravity only, non-radiative hydrodynamics and full feedback physics runs by looking at the overall subhalo/galaxy distribution and on an individual objects basis. We find the subhalo population is reproduced to within $\lesssim10\%$ for both dark matter only and non-radiative runs, with individual objects showing code-to-code scatter of $\lesssim0.1$ dex, although the gas in non-radiative simulations shows significant scatter. Including feedback physics significantly increases the diversity. Subhalo mass and $V_{max}$ distributions vary by $\approx20\%$. The galaxy populations also show striking code-to-code variations. Although the Tully-Fisher relation is similar in almost all codes, the number of galaxies with $10^{9}M_\odot/h\lesssim M_*\lesssim 10^{12}M_\odot/h$ can differ by a factor of 4. Individual galaxies show code-to-code scatter of $\sim0.5$ dex in stellar mass. Moreover, strong systematic differences exist, with some codes producing galaxies $70\%$ smaller than others. The diversity partially arises from the inclusion/absence of AGN feedback. Our results combined with our companion papers demonstrate that subgrid physics is not just subject to fine-tuning, but the complexity of building galaxies in all environments remains a challenge. We argue even basic galaxy properties, such as the stellar mass to halo mass, should be treated with errors bars of $\sim0.2-0.4$ dex., Comment: 17 pages (+4 page appendix), 16 figures, 2 tables; accepted for publication in MNRAS
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- 2015
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8. Geometrical on-the-fly shock detection in SPH
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Beck, Alexander M., Dolag, K., and Donnert, Julius M. F.
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Astrophysics - Instrumentation and Methods for Astrophysics ,Astrophysics - Cosmology and Nongalactic Astrophysics - Abstract
We present an on-the-fly geometrical approach for shock detection and Mach number calculation in simulations employing smoothed particle hydrodynamics (SPH). We utilize pressure gradients to select shock candidates and define up- and downstream positions. We obtain hydrodynamical states in the up- and downstream regimes with a series of normal and inverted kernel weightings parallel and perpendicular to the shock normals. Our on-the-fly geometrical Mach detector incorporates well within the SPH formalism and has low computational cost. We implement our Mach detector into the simulation code GADGET and alongside many SPH improvements. We test our shock finder in a sequence of shock-tube tests with successively increasing Mach numbers exceeding by far the typical values inside galaxy clusters. For all shocks, we resolve the shocks well and the correct Mach numbers are assigned. An application to a strong magnetized shock-tube gives stable results in full magnetohydrodynamic set-ups. We simulate a merger of two idealized galaxy clusters and study the shock front. Shock structures within the merging clusters as well as the cluster shock are well-captured by our algorithm and assigned correct Mach numbers., Comment: 9 pages, 9 figures, accepted to MNRAS
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- 2015
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9. nIFTy galaxy cluster simulations II: radiative models
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Sembolini, Federico, Elahi, Pascal Jahan, Pearce, Frazer R., Power, Chris, Knebe, Alexander, Kay, Scott T., Cui, Weiguang, Yepes, Gustavo, Beck, Alexander M., Borgani, Stefano, Cunnama, Daniel, Davé, Romeel, February, Sean, Huang, Shuiyao, Katz, Neal, McCarthy, Ian G., Murante, Giuseppe, Newton, Richard D. A., Perret, Valentin, Saro, Alexandro, Schaye, Joop, and Teyssier, Romain
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Astrophysics - Cosmology and Nongalactic Astrophysics ,Astrophysics - Astrophysics of Galaxies - Abstract
We have simulated the formation of a massive galaxy cluster (M$_{200}^{\rm crit}$ = 1.1$\times$10$^{15}h^{-1}M_{\odot}$) in a $\Lambda$CDM universe using 10 different codes (RAMSES, 2 incarnations of AREPO and 7 of GADGET), modeling hydrodynamics with full radiative subgrid physics. These codes include Smoothed-Particle Hydrodynamics (SPH), spanning traditional and advanced SPH schemes, adaptive mesh and moving mesh codes. Our goal is to study the consistency between simulated clusters modeled with different radiative physical implementations - such as cooling, star formation and AGN feedback. We compare images of the cluster at $z=0$, global properties such as mass, and radial profiles of various dynamical and thermodynamical quantities. We find that, with respect to non-radiative simulations, dark matter is more centrally concentrated, the extent not simply depending on the presence/absence of AGN feedback. The scatter in global quantities is substantially higher than for non-radiative runs. Intriguingly, adding radiative physics seems to have washed away the marked code-based differences present in the entropy profile seen for non-radiative simulations in Sembolini et al. (2015): radiative physics + classic SPH can produce entropy cores. Furthermore, the inclusion/absence of AGN feedback is not the dividing line -as in the case of describing the stellar content- for whether a code produces an unrealistic temperature inversion and a falling central entropy profile. However, AGN feedback does strongly affect the overall stellar distribution, limiting the effect of overcooling and reducing sensibly the stellar fraction., Comment: 20 pages, 13 figures, submitted to MNRAS
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- 2015
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10. Neutral hydrogen in galaxy clusters: impact of AGN feedback and implications for intensity mapping
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Villaescusa-Navarro, Francisco, Planelles, Susana, Borgani, Stefano, Viel, Matteo, Rasia, Elena, Murante, Giuseppe, Dolag, Klaus, Steinborn, Lisa K., Biffi, Veronica, Beck, Alexander M., and Ragone-Figueroa, Cinthia
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Astrophysics - Cosmology and Nongalactic Astrophysics ,Astrophysics - Astrophysics of Galaxies - Abstract
By means of zoom-in hydrodynamic simulations we quantify the amount of neutral hydrogen (HI) hosted by groups and clusters of galaxies. Our simulations, which are based on an improved formulation of smoothed particle hydrodynamics (SPH), include radiative cooling, star formation, metal enrichment and supernova feedback, and can be split in two different groups, depending on whether feedback from active galactic nuclei (AGN) is turned on or off. Simulations are analyzed to account for HI self-shielding and the presence of molecular hydrogen. We find that the mass in neutral hydrogen of dark matter halos monotonically increases with the halo mass and can be well described by a power-law of the form $M_{\rm HI}(M,z)\propto M^{3/4}$. Our results point out that AGN feedback reduces both the total halo mass and its HI mass, although it is more efficient in removing HI. We conclude that AGN feedback reduces the neutral hydrogen mass of a given halo by $\sim50\%$, with a weak dependence on halo mass and redshift. The spatial distribution of neutral hydrogen within halos is also affected by AGN feedback, whose effect is to decrease the fraction of HI that resides in the halo inner regions. By extrapolating our results to halos not resolved in our simulations we derive astrophysical implications from the measurements of $\Omega_{\rm HI}(z)$: halos with circular velocities larger than $\sim25~{\rm km/s}$ are needed to host HI in order to reproduce observations. We find that only the model with AGN feedback is capable of reproducing the value of $\Omega_{\rm HI}b_{\rm HI}$ derived from available 21cm intensity mapping observations., Comment: 19 pages, 12 figures. Accepted for publication in MNRAS
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- 2015
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11. nIFTy galaxy cluster simulations I: dark matter & non-radiative models
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Sembolini, Federico, Yepes, Gustavo, Pearce, Frazer R., Knebe, Alexander, Kay, Scott T., Power, Chris, Cui, Weiguang, Beck, Alexander M., Borgani, Stefano, Vecchia, Claudio Dalla, Davé, Romeel, Elahi, Pascal Jahan, February, Sean, Huang, Shuiyao, Hobbs, Alex, Katz, Neal, Lau, Erwin, McCarthy, Ian G., Murante, Giuseppe, Nagai, Daisuke, Nelson, Kaylea, Newton, Richard D. A., Puchwein, Ewald, Read, Justin I., Saro, Alexandro, Schaye, Joop, and Thacker, Robert J.
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Astrophysics - Cosmology and Nongalactic Astrophysics - Abstract
We have simulated the formation of a galaxy cluster in a $\Lambda$CDM universe using twelve different codes modeling only gravity and non-radiative hydrodynamics (\art, \arepo, \hydra\ and 9 incarnations of GADGET). This range of codes includes particle based, moving and fixed mesh codes as well as both Eulerian and Lagrangian fluid schemes. The various GADGET implementations span traditional and advanced smoothed-particle hydrodynamics (SPH) schemes. The goal of this comparison is to assess the reliability of cosmological hydrodynamical simulations of clusters in the simplest astrophysically relevant case, that in which the gas is assumed to be non-radiative. We compare images of the cluster at $z=0$, global properties such as mass, and radial profiles of various dynamical and thermodynamical quantities. The underlying gravitational framework can be aligned very accurately for all the codes allowing a detailed investigation of the differences that develop due to the various gas physics implementations employed. As expected, the mesh-based codes ART and AREPO form extended entropy cores in the gas with rising central gas temperatures. Those codes employing traditional SPH schemes show falling entropy profiles all the way into the very centre with correspondingly rising density profiles and central temperature inversions. We show that methods with modern SPH schemes that allow entropy mixing span the range between these two extremes and the latest SPH variants produce gas entropy profiles that are essentially indistinguishable from those obtained with grid based methods., Comment: 21 pages, 13 figures, 4 tables - submitted to MNRAS
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- 2015
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12. Past, present and future of glycolipids from Ustilaginaceae – A review on cellobiose lipids and mannosylerythritol lipids.
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Münßinger, Sini, Beck, Alexander, Oraby, Amira, and Zibek, Susanne
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MOLECULAR structure , *MICROBIOLOGICAL synthesis , *BIOSURFACTANTS , *SOLVENT extraction , *MOIETIES (Chemistry) , *GLYCOLIPIDS - Abstract
The glycolipids cellobiose lipids (CL) and mannosylerythritol lipids (MEL) are biosurfactants mainly synthesized by microorganisms of the Ustilaginaceae family. They have a large structural diversity, varying in their sugar moieties and the attached fatty acids, resulting in a prospectively broad range of applications. This literature review provides a detailed overview of known microbial producers of CL and MEL, and their respective metabolic pathways that result in different molecular structures. Further, current advances in the aerobic fermentative synthesis of the glycolipids and their purification methods are illustrated. All influencing factors identified to date with regard to the fermentation are highlighted in detail: For CL synthesis usually hydrophilic carbon sources are used as substrate, whereas hydrophobic carbon sources are usually metabolized to MEL. Nitrogen limitation was described as a major trigger for glycolipid synthesis and an acidic pH range was favored for increased CL production. An overview of applied fermentation parameters in recent publications (e.g., substrate‐concentrations, feeding approaches) demonstrates the future potential of CL and MEL production optimization. Foaming during fermentation is either combated or exploited by foam fractionation as the first purification step. The current purification processes focus on solvent extractions and chromatography in the laboratory scale and a need for development was identified for future scale‐up. Finally, environmental hotspots during CL and MEL production are presented and future optimization potentials are highlighted. [ABSTRACT FROM AUTHOR]
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- 2024
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13. Anisotropic thermal conduction in galaxy clusters with MHD in Gadget
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Arth, Alexander, Dolag, Klaus, Beck, Alexander M., Petkova, Margarita, and Lesch, Harald
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Astrophysics - Cosmology and Nongalactic Astrophysics ,Astrophysics - High Energy Astrophysical Phenomena - Abstract
We present an implementation of thermal conduction including the anisotropic effects of magnetic fields for SPH. The anisotropic thermal conduction is mainly proceeding parallel to magnetic fields and suppressed perpendicular to the fields. We derive the SPH formalism for the anisotropic heat transport and solve the corresponding equation with an implicit conjugate gradient scheme. We discuss several issues of unphysical heat transport in the cases of extreme ansiotropies or unmagnetized regions and present possible numerical workarounds. We implement our algorithm into the GADGET code and study its behaviour in several test cases. In general, we reproduce the analytical solutions of our idealised test problems, and obtain good results in cosmological simulations of galaxy cluster formations. Within galaxy clusters, the anisotropic conduction produces a net heat transport similar to an isotropic Spitzer conduction model with an efficiency of one per cent. In contrast to isotropic conduction our new formalism allows small-scale structure in the temperature distribution to remain stable, because of their decoupling caused by magnetic field lines. Compared to observations, isotropic conduction with more than 10 per cent of the Spitzer value leads to an oversmoothed temperature distribution within clusters, while the results obtained with anisotropic thermal conduction reproduce the observed temperature fluctuations well. A proper treatment of heat transport is crucial especially in the outskirts of clusters and also in high density regions. It's connection to the local dynamical state of the cluster also might contribute to the observed bimodal distribution of cool core and non cool core clusters. Our new scheme significantly advances the modelling of thermal conduction in numerical simulations and overall gives better results compared to observations., Comment: 25 pages, 18 figures
- Published
- 2014
14. New constraints on modelling the random magnetic field of the MW
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Beck, Marcus C., Beck, Alexander M., Beck, Rainer, Dolag, Klaus, Strong, Andrew W., and Nielaba, Peter
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Astrophysics - Astrophysics of Galaxies ,Astrophysics - High Energy Astrophysical Phenomena - Abstract
We extend the description of the isotropic and anisotropic random component of the small-scale magnetic field within the existing magnetic field model of the Milky Way from Jansson&Farrar, by including random realizations of the small-scale component. Using a magnetic-field power spectrum with Gaussian random fields, the NE2001 model for the thermal electrons and the Galactic cosmic-ray electron distribution from the current GALPROP model we derive full-sky maps for the total and polarized synchrotron intensity as well as the Faraday rotation-measure distribution. While previous work assumed that small-scale fluctuations average out along the line-of-sight or which only computed ensemble averages of random fields, we show that these fluctuations need to be carefully taken into account. Comparing with observational data we obtain not only good agreement with 408 MHz total and WMAP7 22 GHz polarized intensity emission maps, but also an improved agreement with Galactic foreground rotation-measure maps and power spectra, whose amplitude and shape strongly depend on the parameters of the random field. We demonstrate that a correlation length of ~220pc (50pc being a 5\sigma lower limit) is needed to match the slope of the observed power spectrum of Galactic foreground rotation-measure maps. Using multiple realizations allows us also to infer errors on individual observables. We find that previously-used amplitudes for random and anisotropic random magnetic field components need to be rescaled by factors of ~0.3 and 0.6 to account for the new small-scale contributions. Our model predicts a rotation measure of -2.8\pm7.1 rad/m^2 and 4.4\pm11.0 rad/m^2 for the north and south Galactic poles respectively, in good agreement with observations. Applying our model to deflections of ultra-high-energy cosmic rays we infer a mean deflection of ~3.5\pm1.1 degree for 60 EeV protons arriving from CenA., Comment: 28 pages, 12 figures, 2 tables
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- 2014
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15. A Vade Mecum on Official Investigation on Organic Products. Good Implementation Practices for Articles 28 and 29 of Regularion (EU) 2018/848
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Bauer, Lea, Beck, Alexander, Belliere, Samanta Rosi, Catrou, Olivier, Fritz, Rosi, Fuchsbauer, Norbert, Galashevskyy, Sergiy, Garancs, Janis, Gonzalez, Christine, Hartung, Mathis, Könen, Philipp Peter, Lippert, Felix, Lignon, Bernard, Lind, Robert, Marchand, Julie, Maresca, Roberto, Neuendorff, Jochen, Nizet, Tom, Novak, Christian, Pfannkuchen, Carmen, Simon, Monika, Speiser, Bernhard, Verlet, Nicolas, Vidal, Rodolphe, Vido, Laurence, Bauer, Lea, Beck, Alexander, Belliere, Samanta Rosi, Catrou, Olivier, Fritz, Rosi, Fuchsbauer, Norbert, Galashevskyy, Sergiy, Garancs, Janis, Gonzalez, Christine, Hartung, Mathis, Könen, Philipp Peter, Lippert, Felix, Lignon, Bernard, Lind, Robert, Marchand, Julie, Maresca, Roberto, Neuendorff, Jochen, Nizet, Tom, Novak, Christian, Pfannkuchen, Carmen, Simon, Monika, Speiser, Bernhard, Verlet, Nicolas, Vidal, Rodolphe, and Vido, Laurence
- Abstract
The issue of traces of non-authorized substances in organic products, mainly pesticides, was one of the hot topics during the development of the new EU Organic Regulation, and the debate continues. If such substances are found, an official investigation must be conducted to determine the source and cause of contamination. A product can only be sold as organic if no major or critical non-compliances are found. The products concerned cannot be sold as organic until the investigation is concluded. The issue has generated numerous reactions and discussions. Organic consumers need to be protected against fraud. On the other hand, pesticides from conventional agriculture are everywhere, sometimes it is difficult to determine their origin. Systematic investigations might be burdensome, expensive and lead to food waste. To support effective and efficient official investigations, a "Vade mecum on official investigation in organic products" has just been published, guiding investigation methods and techniques.
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- 2024
16. Strong magnetic fields and large rotation measures in protogalaxies by supernova seeding
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Beck, Alexander M., Dolag, Klaus, Lesch, Harald, and Kronberg, Philipp P.
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Astrophysics - Astrophysics of Galaxies ,Astrophysics - Cosmology and Nongalactic Astrophysics - Abstract
We present a model for the seeding and evolution of magnetic fields in protogalaxies. Supernova (SN) explosions during the assembly of a protogalaxy provide magnetic seed fields, which are subsequently amplified by compression, shear flows and random motions. We implement the model into the MHD version of the cosmological N-body / SPH simulation code GADGET and we couple the magnetic seeding directly to the underlying multi-phase description of star formation. We perform simulations of Milky Way-like galactic halo formation using a standard LCDM cosmology and analyse the strength and distribution of the subsequent evolving magnetic field. A dipole-shape divergence-free magnetic field is injected at a rate of 10^{-9}G / Gyr within starforming regions, given typical dimensions and magnetic field strengths in canonical SN remnants. Subsequently, the magnetic field strength increases exponentially on timescales of a few ten million years. At redshift z=0, the entire galactic halo is magnetized and the field amplitude is of the order of a few $\mu$G in the center of the halo, and 10^{-9} G at the virial radius. Additionally, we analyse the intrinsic rotation measure (RM) of the forming galactic halo over redshift. The mean halo intrinsic RM peaks between redshifts z=4 and z=2 and reaches absolute values around 1000 rad m^{-2}. While the halo virializes towards redshift z=0, the intrinsic RM values decline to a mean value below 10 rad m^{-2}. At high redshifts, the distribution of individual starforming, and thus magnetized regions is widespread. In our model for the evolution of galactic magnetic fields, the seed magnetic field amplitude and distribution is no longer a free parameter, but determined self-consistently by the star formation process occuring during the formation of cosmic structures., Comment: 13 pages, 14 figures, accepted to MNRAS after moderate revision
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- 2013
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17. Shear transfer across cracks in steel fibre reinforced concrete
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Kaufmann, Walter, Amin, Ali, Beck, Alexander, and Lee, Minu
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- 2019
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18. On the magnetic fields in voids
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Beck, Alexander M., Hanasz, Michal, Lesch, Harald, Remus, Rhea-Silvia, and Stasyszyn, Federico A.
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Astrophysics - Cosmology and Nongalactic Astrophysics ,Astrophysics - Astrophysics of Galaxies - Abstract
We study the possible magnetization of cosmic voids by void galaxies. Recently, observations revealed isolated starforming galaxies within the voids. Furthermore, a major fraction of a voids volume is expected to be filled with magnetic fields of a minimum strength of about $10^{-15}$ G on Mpc scales. We estimate the transport of magnetic energy by cosmic rays (CR) from the void galaxies into the voids. We assume that CRs and winds are able to leave small isolated void galaxies shortly after they assembled, and then propagate within the voids. For a typical void, we estimate the magnetic field strength and volume filling factor depending on its void galaxy population and possible contributions of strong active galactic nuclei (AGN) which border the voids. We argue that the lower limit on the void magnetic field can be recovered, if a small fraction of the magnetic energy contained in the void galaxies or void bordering AGNs is distributed within the voids., Comment: 5 pages, 2 figures, accepted to MNRAS Letters after moderate revision
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- 2012
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19. Synthetic X-ray and radio maps for two different models of Stephan's Quintet
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Geng, Annette, Beck, Alexander M., Dolag, Klaus, Bürzle, Florian, Beck, Marcus C., Kotarba, Hanna, and Nielaba, Peter
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Astrophysics - Astrophysics of Galaxies - Abstract
We present simulations of the compact galaxy group Stephan's Quintet (SQ) including magnetic fields, performed with the N-body/smoothed particle hydrodynamics (SPH) code \textsc{Gadget}. The simulations include radiative cooling, star formation and supernova feedback. Magnetohydrodynamics (MHD) is implemented using the standard smoothed particle magnetohydrodynamics (SPMHD) method. We adapt two different initial models for SQ based on Renaud et al. and Hwang et al., both including four galaxies (NGC 7319, NGC 7320c, NGC 7318a and NGC 7318b). Additionally, the galaxies are embedded in a magnetized, low density intergalactic medium (IGM). The ambient IGM has an initial magnetic field of $10^{-9}$ G and the four progenitor discs have initial magnetic fields of $10^{-9} - 10^{-7}$ G. We investigate the morphology, regions of star formation, temperature, X-ray emission, magnetic field structure and radio emission within the two different SQ models. In general, the enhancement and propagation of the studied gaseous properties (temperature, X-ray emission, magnetic field strength and synchrotron intensity) is more efficient for the SQ model based on Renaud et al., whose galaxies are more massive, whereas the less massive SQ model based on Hwang et al. shows generally similar effects but with smaller efficiency. We show that the large shock found in observations of SQ is most likely the result of a collision of the galaxy NGC 7318b with the IGM. This large group-wide shock is clearly visible in the X-ray emission and synchrotron intensity within the simulations of both SQ models. The order of magnitude of the observed synchrotron emission within the shock front is slightly better reproduced by the SQ model based on Renaud et al., whereas the distribution and structure of the synchrotron emission is better reproduced by the SQ model based on Hwang et al.., Comment: 20 pages, 15 figures, accepted to MNRAS
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- 2012
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20. Origin of strong magnetic fields in Milky-Way like galactic haloes
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Beck, Alexander M., Lesch, Harald, Dolag, Klaus, Kotarba, Hanna, Geng, Annette, and Stasyszyn, Federico A.
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Astrophysics - Cosmology and Nongalactic Astrophysics ,Astrophysics - Astrophysics of Galaxies - Abstract
An analytical model predicting the growth rates, the absolute growth times and the saturation values of the magnetic field strength within galactic haloes is presented. The analytical results are compared to cosmological MHD simulations of Milky-Way like galactic halo formation performed with the N-body / \textsc{Spmhd} code \textsc{Gadget}. The halo has a mass of $\approx{}3\cdot{}10^{12}$ $M_{\odot}$ and a virial radius of $\approx{}$270 kpc. The simulations in a $\Lambda$CDM cosmology also include radiative cooling, star formation, supernova feedback and the description of non-ideal MHD. A primordial magnetic seed field ranging from $10^{-10}$ to $10^{-34}$ G in strength agglomerates together with the gas within filaments and protohaloes. There, it is amplified within a couple of hundred million years up to equipartition with the corresponding turbulent energy. The magnetic field strength increases by turbulent small-scale dynamo action. The turbulence is generated by the gravitational collapse and by supernova feedback. Subsequently, a series of halo mergers leads to shock waves and amplification processes magnetizing the surrounding gas within a few billion years. At first, the magnetic energy grows on small scales and then self-organizes to larger scales. Magnetic field strengths of $\approx{}10^{-6}$ G are reached in the center of the halo and drop to $\approx{}10^{-9}$ G in the IGM. Analyzing the saturation levels and growth rates, the model is able to describe the process of magnetic amplification notably well and confirms the results of the simulations., Comment: 13 pages, 12 figures, accepted to MNRAS after minor revision
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- 2012
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21. Magnetic field amplification and X-ray emission in galaxy minor mergers
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Geng, Annette, Kotarba, Hanna, Bürzle, Florian, Dolag, Klaus, Stasyszyn, Federico, Beck, Alexander, and Nielaba, Peter
- Subjects
Astrophysics - Astrophysics of Galaxies - Abstract
We investigate the magnetic field evolution in a series of galaxy minor mergers using the N-body/smoothed particle hydrodynamics (SPH) code \textsc{Gadget}. The simulations include the effects of radiative cooling, star formation and supernova feedback. Magnetohydrodynamics (MHD) is implemented using the SPH method. We present 32 simulations of binary mergers of disc galaxies with mass ratios of 2:1 up to 100:1, whereby we have additionally varied the initial magnetic field strengths, disc orientations and resolutions. We investigate the amplification of a given initial magnetic field within the galaxies and an ambient intergalactic medium (IGM) during the interaction. We find that the magnetic field strengths of merger remnants with mass ratios up to 10:1 saturate at a common value of several $\mu$G. For higher mass ratios, the field strength saturates at lower values. The saturation values correspond to the equipartition value of magnetic and turbulent energy density. The initial magnetization, disc orientation and numerical resolution show only minor effects on the saturation value of the magnetic field. We demonstrate that a higher impact energy of the progenitor galaxies leads to a more efficient magnetic field amplification. The magnetic and turbulent energy densities are higher for larger companion galaxies, consistent with the higher impact energy supplied to the system. We present a detailed study of the evolution of the temperature and the bolometric X-ray luminosity within the merging systems. Thereby we find that magnetic fields cause a more efficient increase of the IGM temperature and the corresponding IGM X-ray luminosity after the first encounter. However, the presence of magnetic fields does not enhance the total X-ray luminosity. Generally, the final value of the X-ray luminosity is even clearly lower for higher initial magnetic fields., Comment: 20 pages, 12 figures. Submitted to MNRAS
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- 2011
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22. Influence of microorganism and plant oils on the structure of mannosylerythritol lipid (MEL) biosurfactants revealed by a novel thin layer chromatography mass spectrometry method
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Beck, Alexander, Haitz, Fabian, Grunwald, Saskia, Preuss, Laura, Rupp, Steffen, and Zibek, Susanne
- Published
- 2019
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23. EPCO-45. CELLULAR HIERARCHIES OF ETMR ARE SHAPED BY ONCOGENIC MICRORNAS AND RECEPTOR-LIGAND INTERACTIONS
- Author
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Gabler, Lisa, primary, Beck, Alexander, additional, Cruzeiro, Gustavo, additional, Lambo, Sander, additional, Englinger, Bernhard, additional, Shaw, McKenzie L, additional, Hack, Olivia, additional, Chi, Susan, additional, Alexandrescu, Sanda, additional, Gojo, Johannes, additional, Kool, Marcel, additional, Hovestadt, Volker, additional, and Filbin, Mariella, additional
- Published
- 2023
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24. DDDR-17. CLINICAL RESPONSE TO THE PDGFRA/KIT INHIBITOR AVAPRITINIB IN PEDIATRIC AND YOUNG ADULT HIGH-GRADE GLIOMA PATIENTS
- Author
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Mayr, Lisa, primary, Trissal, Maria, additional, Schwark, Kallen, additional, Neyazi, Sina, additional, Beck, Alexander, additional, Labelle, Jenna, additional, Marques, Joana Graca, additional, Weiler-Wichtl, Liesa, additional, Madlener, Sibylle, additional, Kong, Seongbae, additional, Miclea, Madeline, additional, Supko, Jeffrey, additional, Guntner, Armin Sebastian, additional, Palova, Hana, additional, Neradil, Jakub, additional, Stepien, Natalia, additional, Loetsch-Gojo, Daniela, additional, Dorfer, Christian, additional, Dieckmann, Karen, additional, Peyrl, Andreas, additional, Azizi, Amedeo A, additional, Baumgartner, Alicia-Christina, additional, Slaby, Ondrej, additional, Pokorna, Petra, additional, Dubois, Frank, additional, Greenwald, Noah, additional, Bandopadhayay, Pratiti, additional, Beroukhim, Rameen, additional, Ligon, Keith, additional, Kramm, Christof, additional, Bronsema, Annika, additional, Bailey, Simon, additional, Stuecklin, Ana Guerreiro, additional, Mueller, Sabine, additional, Skrypek, Mary, additional, Martinez, Nina, additional, Bowers, Daniel C, additional, Jones, David, additional, Jones, Chris, additional, Jaeger, Natalie, additional, Sterba, Jaroslav, additional, Müllauer, Leonhard, additional, Haberler, Christine, additional, Kumar-Sinha, Chandan, additional, Chinnaiyan, Arul, additional, Mody, Rajen, additional, Furtner-Srajer, Julia, additional, Koschmann, Carl, additional, Gojo, Johannes, additional, and Filbin, Mariella, additional
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- 2023
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25. Deciphering sources of PET signals in the tumor microenvironment of glioblastoma at cellular resolution
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Bartos, Laura M., primary, Kirchleitner, Sabrina V., additional, Kolabas, Zeynep Ilgin, additional, Quach, Stefanie, additional, Beck, Alexander, additional, Lorenz, Julia, additional, Blobner, Jens, additional, Mueller, Stephan A., additional, Ulukaya, Selin, additional, Hoeher, Luciano, additional, Horvath, Izabela, additional, Wind-Mark, Karin, additional, Holzgreve, Adrien, additional, Ruf, Viktoria C., additional, Gold, Lukas, additional, Kunze, Lea H., additional, Kunte, Sebastian T., additional, Beumers, Philipp, additional, Park, Ha Eun, additional, Antons, Melissa, additional, Zatcepin, Artem, additional, Briel, Nils, additional, Hoermann, Leonie, additional, Schaefer, Rebecca, additional, Messerer, Denise, additional, Bartenstein, Peter, additional, Riemenschneider, Markus J., additional, Lindner, Simon, additional, Ziegler, Sibylle, additional, Herms, Jochen, additional, Lichtenthaler, Stefan F., additional, Ertürk, Ali, additional, Tonn, Joerg C., additional, von Baumgarten, Louisa, additional, Albert, Nathalie L., additional, and Brendel, Matthias, additional
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- 2023
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26. Life cycle assessment for early-stage process optimization of microbial biosurfactant production using kinetic models--a case study on mannosylerythritol lipids (MEL).
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Bippus, Lars, Briem, Ann-Kathrin, Beck, Alexander, Zibek, Susanne, and Albrecht, Stefan
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- 2024
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27. Mannosylerythritollipide — mikrobielle Biotenside aus dem Bioreaktor
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Beck, Alexander and Zibek, Susanne
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- 2020
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28. DIPG-19. BAF COMPLEX PERTURBATION AS A NOVEL THERAPEUTIC OPPORTUNITY IN H3K27M PEDIATRIC GLIOMA
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Panditharatna, Eshini, primary, Marques, Joana G, additional, Wang, Tingjian, additional, Trissal, Maria, additional, Liu, Ilon, additional, Jiang, Li, additional, Beck, Alexander, additional, Groves, Andrew, additional, Dharia, Neekesh, additional, Hoffman, Samantha, additional, Kugener, Guillaume, additional, Shaw, McKenzie, additional, Hack, Olivia, additional, Dempster, Joshua, additional, Lareau, Caleb, additional, Quezada, Michael, additional, Stanton, Ann-Catherine, additional, Wyatt, Meghan, additional, Kalani, Zohra, additional, Goodale, Amy, additional, Vazquez, Francisca, additional, Piccioni, Federica, additional, Doench, John, additional, Root, David, additional, Anastas, Jamie, additional, Jones, Kristen, additional, Conway, Amy, additional, Stopka, Sylwia, additional, Regan, Michael, additional, Liang, Yu, additional, Seo, Hyuk-Soo, additional, Song, Kijun, additional, Bashyal, Puspalata, additional, Mathewson, Nathan, additional, Dhe-Paganon, Sirano, additional, Suvà, Mario L, additional, Carcaboso, Angel M, additional, Lavarino, Cinzia, additional, Mora, Jaume, additional, Nguyen, Quang-De, additional, Ligon, Keith L, additional, Shi, Yang, additional, Agnihotri, Sameer, additional, Agar, Nathalie Y R, additional, Stegmaier, Kimberly, additional, Stiles, Charles D, additional, Monje, Michelle, additional, Golub, Todd R, additional, Qi, Jun, additional, and Filbin, Mariella G, additional
- Published
- 2023
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29. Using neural networks to aid CVSS risk aggregation — An empirically validated approach
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Beck, Alexander and Rass, Stefan
- Published
- 2016
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30. Influence of reduction accuracy in lateral tibial plateau fractures on intra-articular friction – a biomechanical study
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Walter, Christian, Beck, Alexander, Jacob, Christopher, Hofmann, Ulf Krister, Stöckle, Ulrich, and Stuby, Fabian
- Published
- 2020
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31. Prognostic Implications of Global Longitudinal Strain by Feature-Tracking Cardiac Magnetic Resonance in ST-Elevation Myocardial Infarction
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Reindl, Martin, Tiller, Christina, Holzknecht, Magdalena, Lechner, Ivan, Beck, Alexander, Plappert, David, Gorzala, Michelle, Pamminger, Mathias, Mayr, Agnes, Klug, Gert, Bauer, Axel, Metzler, Bernhard, and Reinstadler, Sebastian J.
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- 2019
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32. Erarbeitung eines Code of Practice (CoP) für die ökologische Lebensmittelverarbeitung
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Beck, Alexander and Beck, Alexander
- Abstract
Dieses Aufstockungsprojekt baut auf dem EU-Projekt ProOrg auf. Im Rahmen des ProOrg Projekts wurde ein sogenannter „Code of Practice (CoP)“ für Akteure der BioVerarbeitungsbranche entwickelt. Dieser besteht aus einer „Management Guideline“ (ein Leitfaden für die Umsetzung des EU-Bio Rechts für die Verarbeitungspraxis), einem „Assessment Framework“ (ein Bewertungssystem zum Vergleich von Verarbeitungstechnologien hinsichtlich ihrer Bio-Tauglichkeit) und einer „Communication Guideline“ (einem Leitfaden zur Kommunikation der Verarbeitungstechnik an die Zielgruppe). Diese drei Teilergebnisse enthalten ein so hohes Potential, dass diese über das Projekt hinaus im Rahmen dieses Aufstockungsprojekts weiterentwickelt/aufbereitet wurden, um alle Ergebnisse zugänglicher an die jeweilige Zielgruppe zu vermitteln. Dafür wurde das Tool EVA TechProof, das den Assessment Framework für die tägliche Anwendungspraxis verfügbar macht, als Teil des CoP’s, auf einer Online-Plattform entwickelt und finalisiert. Auch die Management Guideline, inklusive Einführungsfilm und die Kommunikationsleitlinie wurden dort der Zielgruppe zur Verfügung gestellt. Diese neuen Entwicklungen wurden auf der Biofach dem Fachpublikum präsentiert. Zusätzlich ist es wichtig Studierende der Ernährungs- und Lebensmittelbranche für die Themen des ProOrg Projekts zu sensibilisieren. Deswegen wurde eine Veranstaltung zu diesem Thema mit Studierenden durchgeführt und mit ihnen über die Themen Bio- Verarbeitung, Lebensmittelqualität und schonende Verarbeitungstechnologien gesprochen.
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- 2023
33. General Concepts and Recent Advances in the Electrochemical Transformation of Chloro‐ and Hydrosilanes
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Beck, Alexander D., primary, Haufe, Stefan, additional, and Waldvogel, Siegfried R., additional
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- 2023
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34. Entwicklung neuartiger statistischer Downscalingansätze unter besonderer Berücksichtigung von Instationaritäten
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Hertig, Elke, Jacobeit, Jucundus, Merkenschlager, Christian, and Beck, Alexander
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ddc:550 - Published
- 2022
35. Overexpression of UHRF1 promotes silencing of tumor suppressor genes and predicts outcome in hepatoblastoma
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Beck, Alexander, Trippel, Franziska, Wagner, Alexandra, Joppien, Saskia, Felle, Max, Vokuhl, Christian, Schwarzmayr, Thomas, Strom, Tim M., von Schweinitz, Dietrich, Längst, Gernot, and Kappler, Roland
- Published
- 2018
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36. Searching for primaries in patients with neuroendocrine tumors (NET) of unknown primary and clinically suspected NET: Evaluation of Ga-68 DOTATOC PET/CT and In-111 DTPA octreotide SPECT/CT
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Schreiter Nils Friedemann, Bartels Ann-Mirja, Froeling Vera, Steffen Ingo, Pape Ulrich-Frank, Beck Alexander, Hamm Bernd, Brenner Winfried, and Röttgen Rainer
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net ,cup ,ga-68 dotatoc pet/ct ,in-111 dtpa octreotide spect ,clinically suspected net ,Medical physics. Medical radiology. Nuclear medicine ,R895-920 - Abstract
Background. To evaluate the clinical efficacy of In-111 DTPA octreotide SPECT/CT and Ga-68 DOTATOC PET/CT for detection of primary tumors in patients with either neuroendocrine tumor of unknown primary (NETUP) or clinically suspected primary NET (SNET).
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- 2014
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37. EPCO-21. THE SPATIAL ORGANIZATION OF H3-K27M MUTANT DIFFUSE MIDLINE GLIOMA
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Liu, Ilon, primary, Li, Jiang, additional, Samuelsson, Erik, additional, Salas, Sergio Marco, additional, Beck, Alexander, additional, Hack, Olivia, additional, Jeong, Daeun, additional, Shaw, McKenzie, additional, Englinger, Bernhard, additional, Labelle, Jenna, additional, Mire, Hafsa, additional, Madlener, Sibylle, additional, Mayr, Lisa, additional, Quezada, Michael, additional, Trissal, Maria, additional, Panditharatna, Eshini, additional, Ernst, Kati, additional, Gatesman, Taylor, additional, Halbert, Matthew, additional, Palova, Hana, additional, Pokorna, Petra, additional, Sterba, Jaroslav, additional, Slaby, Ondrej, additional, Geyeregger, Rene, additional, Diaz, Aaron, additional, Resnick, Adam C, additional, Suva, Mario, additional, Jones, David, additional, Agnihotri, Sameer, additional, Ostlin, Jessica, additional, Koschmann, Carl, additional, Haberler, Christine, additional, Czech, Thomas, additional, Slavc, Irene, additional, Cotter, Jennifer, additional, Ligon, Keith, additional, Alexandrescu, Sanda, additional, Yung, W K Alfred, additional, Arrillaga-Romany, Isabel, additional, Gojo, Johannes, additional, Monje, Michelle, additional, Nilsson, Mats, additional, and Filbin, Mariella, additional
- Published
- 2022
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38. Scaling law of static liquefaction mechanism in geocentrifuge and corresponding hydromechanical characterization of an unsaturated silty sand having a viscous pore fluid
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Askarinejad, Amin, Beck, Alexander, and Springman, Sarah M.
- Subjects
Silt -- Research ,Liquefaction (Geology) -- Research ,Landslides -- Models -- Switzerland ,Scaling laws (Mathematical physics) -- Research ,Earth sciences - Abstract
Fast landslides induced by rainfall impose considerable damage on infrastructure and cause major casualties worldwide. 1Static liquefaction is one of the triggering mechanisms mentioned frequently in the literature as a cause of this type of landslide. The scaling laws required to model this mechanism in the geotechnical centrifuge are developed, and it is shown that either a reduction in the soil pore size or use of a viscous pore fluid is needed to unify the time scaling factors of contractive volume change of the saturated voids and dissipation of the excess pore pressure generated. The latter option was used in this research; therefore, the influences of the viscous pore fluid on the hydromechanical characteristics of a silty sand were investigated. Subsequently, geocentrifuge tests were conducted to compare the behaviour of a slope having a viscous solution as the pore fluid with that of a model with water as the pore fluid. Both slopes were subjected to rainfall, and the evolution of the pore pressure and surface movements were monitored. Key words: landslide, rainfall, static liquefaction, unsaturated soils, viscous pore fluid, geotechnical centrifuge modelling. Les glissements de terrain rapides provoques par les precipitations pluvieuses infligent des dommages considerables aux infrastructures et font de nombreuses victimes dans le monde entier. La liquefaction statique est l'un des mecanismes declencheurs de ce type de glissement de terrain souvent evoque dans la litterature. Les lois d'echelle necessaires a la modelisation de ce mecanisme en centrifugeuse geotechnique sont elaborees. De plus, il est demontre qu'une reduction de la taille des pores du sol ou l'utilisation d'un fluide interstitiel visqueux est necessaire a l'unification des echelles de temps de la variation du volume par contraction des espaces vides satures et de la dissipation de l'exces de pression interstitielle genere. La derniere option a ete utilisee dans la presente etude et l'influence du fluide interstitiel visqueux sur les caracteristiques hydromecaniques d'un sable silteux a donc ete etudiee. Par la suite, des essais en centrifugeuse ont ete effectues pour comparer le comportement d'une pente contenant une solution visqueuse en guise de fluide interstitiel a celui d'un modele se servant d'eau comme fluide interstitiel. Les deux pentes ont ete soumises fi des precipitations pluvieuses et l'evolution de la pression interstitielle et des mouvements de surface ont ete observes. [Traduit par la Redaction] Mots-cles: glissement de terrain, precipitation pluvieuse, liquefaction statique, sols insatures, fluide interstitiel visqueux, modelisation en centrifugeuse geotechnique., Introduction Landslides induced by long and (or) intense rainfall events affect lives and infrastructure severely in many parts of the world (e.g. Larsen et al. 2001; Lagmay et al. 2006; [...]
- Published
- 2015
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39. DIPG-39. New preclinical models for Diffuse Midline Glioma
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Klenner, Marbod, primary, Freidel, Pia, additional, Filbin, Mariella G, additional, and Beck, Alexander, additional
- Published
- 2022
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40. DIPG-49. International preclinical drug discovery and biomarker program informing an adoptive combinatorial trial for DMG
- Author
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Nazarian, Javad, primary, Dun, Matthew, additional, Kilburn, Lindsay, additional, Waszak, Sebastian, additional, Vitanza, Nicholas, additional, Franson, Andrea, additional, Prados, Mike, additional, Raabe, Eric, additional, Firestein, Ron, additional, Beck, Alexander, additional, Saratsis, Amanda, additional, Rotblat, Barak, additional, van Vuurder, Dannis, additional, Foster, Jessica, additional, Hulleman, Esther, additional, Kline, Cassie, additional, Gupta, Nalin, additional, Cain, Jason, additional, Koschmann, Carl, additional, and Muller, Sabine, additional
- Published
- 2022
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41. Optimization and Kinetic Modeling of a Fed-Batch Fermentation for Mannosylerythritol Lipids (MEL) Production with Moesziomyces aphidis
- Author
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Beck, Alexander, Vogt, Franziska, Hägele, Lorena, Rupp, Steffen, Zibek, Susanne, and Publica
- Subjects
bioreactor ,biosurfactants ,process engineering ,mannosylerythritol lipids ,kinetic modeling ,ustilaginaceae - Abstract
Mannosylerythritol lipids are glycolipid biosurfactants with many interesting properties. Despite the general interest in those molecules and the need for a robust process, studies on their production in bioreactors are still scarce. In the current study, the fermentative production of MEL in a bioreactor with Moesziomyces aphidis was performed using a defined mineral salt medium. Several kinetic process parameters like substrate consumption rates and product formation rates were evaluated and subsequently enhanced by increasing the biomass concentration through an exponential fed-batch strategy. The fed-batch approaches resulted in two to three fold increased dry biomass concentrations of 10.9-15.5 g/L at the end of the growth phase, compared with 4.2 g/L in the batch process. Consequently, MEL formation rates were increased from 0.1 g/Lh up to around 0.4 g/Lh during the MEL production phase. Thus, a maximum concentration of up to 50.5 g/L MEL was obtained when oil was added in excess, but high concentrations of residual fatty acids were also present in the broth. By adjusting the oil feeding to biomass-specific hydrolysis and MEL production rates, a slightly lower MEL concentration of 34.3 g/L was obtained after 170 h, but at the same time a very pure crude lipid extract with more than 90% MEL and a much lower concentration of remaining fatty acids. With rapeseed oil as substrate, the ideal oil-to-biomass ratio for full substrate conversion was found to be around 10 goil/gbiomass. In addition, off-gas analysis and pH trends could be used to assess biomass growth and MEL production. Finally, kinetic models were developed and compared to the experimental data, allowing for a detailed prediction of the process behavior in future experiments.
- Published
- 2022
42. Problemanalyse und Identifikation des Handlungsbedarfs bei Pflanzenschutzmittel- und Wirkstofffunden in der Bio-Wertschöpfungskette
- Author
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Milan, Marlene, Furtwengler, Jana, Possienke, M., Neuendorff, Jochen, Beck, Alexander, Uthe, Pia, Smith-Weißmann, Kevin, Miglbauer, T., Milan, Marlene, Furtwengler, Jana, Possienke, M., Neuendorff, Jochen, Beck, Alexander, Uthe, Pia, Smith-Weißmann, Kevin, and Miglbauer, T.
- Abstract
Der Umgang mit Funden unzulässiger Pflanzenschutzmittelwirkstoffe entlang der Bio- Wertschöpfungskette stellt eine große Herausforderung für die Branche dar. So kann ein Fund ein Hinweis dafür sein, dass der bio-zertifizierte Produktionsprozess nicht eingehalten wurde. Das bloße Vorhandensein eines Stoffes allein lässt allerdings noch keine Aussagen über die Bio-Integrität des Produkts zu. Im Rahmen des Projekts wurden Problembereiche detailliert analysiert sowie Informationsund Wissenslücken identifiziert. Aus dem Vorhaben resultieren folgende Handlungsempfehlungen: - Für eine sachgerechte Abgrenzung zwischen ubiquitärer Belastung, Wirkungen benachbarter konventioneller Produktionssysteme und Verstößen gegen die Vorgaben der EU-Öko-Verordnung ist eine verbesserte Durchführung und Zugänglichkeit eines umfassenden Umweltmonitorings von im Öko-Landbau unzulässigen Wirkstoffen unerlässlich. - Für eine sachgerechte Beurteilung von unzulässigen Wirkstofffunden entlang der Bio-Wertschöpfungskette steht bislang nur eine unzureichende und heterogene Datenbasis zur Verfügung. Fälle sollten systematisch elektronisch auswertbar dokumentiert werden. Hierzu wird eine verbesserte Erfassung benötigt. - Der einseitige Fokus auf Endproduktanalytik im Kontext moderner Pflanzenschutzmittel-Wirkstoffe kann nur einen begrenzten Beitrag zur Absicherung der Integrität von Bio-Produkten leisten. Bei Bio-Kontrollen sollte künftig stärker die Durchführung von Prozessproben (Betriebsmittel, Blattproben, Staubproben) fokussiert werden. - Die Situationsanalyse zeigt bei der EU-Öko-Kontrolle ein heterogenes Kompetenzniveau im Umgang mit unzulässigen Wirkstofffunden auf. Fachlich fundierte Qualifizierungs- und Bildungsmaßnahmen müssen vorangetrieben werden. - Im EU-weiten Handel führen unterschiedliche Vorgehensweisen mit Wirkstofffunden zu Wettbewerbsverzerrungen. Zusätzlich ist der unternehmensspezifische Umgang sehr heterogen. Vorgehensweisen sollten weiter harmonisiert und unter Berücksichtig
- Published
- 2022
43. The landscape of tumor cell states and spatial organization in H3-K27M mutant diffuse midline glioma across age and location
- Author
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Liu, Ilon, Jiang, Li, Samuelsson, Erik Reinhold, Marco Salas, Sergio, Beck, Alexander, Hack, Olivia A., Jeong, Daeun, Shaw, McKenzie L., Englinger, Bernhard, LaBelle, Jenna, Mire, Hafsa M., Madlener, Sibylle, Mayr, Lisa, Quezada, Michael A., Trissal, Maria, Panditharatna, Eshini, Ernst, Kati J., Vogelzang, Jayne, Gatesman, Taylor A., Halbert, Matthew E., Palova, Hana, Pokorna, Petra, Sterba, Jaroslav, Slaby, Ondrej, Geyeregger, Rene, Diaz, Aaron, Findlay, Izac J., Dun, Matthew D., Resnick, Adam, Suvà, Mario L., Jones, David T. W., Agnihotri, Sameer, Svedlund, Jessica, Koschmann, Carl, Haberler, Christine, Czech, Thomas, Slavc, Irene, Cotter, Jennifer A., Ligon, Keith L., Alexandrescu, Sanda, Yung, W. K. Alfred, Arrillaga-Romany, Isabel, Gojo, Johannes, Monje, Michelle, Nilsson, Mats, Filbin, Mariella G., Liu, Ilon, Jiang, Li, Samuelsson, Erik Reinhold, Marco Salas, Sergio, Beck, Alexander, Hack, Olivia A., Jeong, Daeun, Shaw, McKenzie L., Englinger, Bernhard, LaBelle, Jenna, Mire, Hafsa M., Madlener, Sibylle, Mayr, Lisa, Quezada, Michael A., Trissal, Maria, Panditharatna, Eshini, Ernst, Kati J., Vogelzang, Jayne, Gatesman, Taylor A., Halbert, Matthew E., Palova, Hana, Pokorna, Petra, Sterba, Jaroslav, Slaby, Ondrej, Geyeregger, Rene, Diaz, Aaron, Findlay, Izac J., Dun, Matthew D., Resnick, Adam, Suvà, Mario L., Jones, David T. W., Agnihotri, Sameer, Svedlund, Jessica, Koschmann, Carl, Haberler, Christine, Czech, Thomas, Slavc, Irene, Cotter, Jennifer A., Ligon, Keith L., Alexandrescu, Sanda, Yung, W. K. Alfred, Arrillaga-Romany, Isabel, Gojo, Johannes, Monje, Michelle, Nilsson, Mats, and Filbin, Mariella G.
- Abstract
Histone 3 lysine27-to-methionine (H3-K27M) mutations most frequently occur in diffuse midline gliomas (DMGs) of the childhood pons but are also increasingly recognized in adults. Their potential heterogeneity at different ages and midline locations is vastly understudied. Here, through dissecting the single-cell transcriptomic, epigenomic and spatial architectures of a comprehensive cohort of patient H3-K27M DMGs, we delineate how age and anatomical location shape glioma cell-intrinsic and -extrinsic features in light of the shared driver mutation. We show that stem-like oligodendroglial precursor-like cells, present across all clinico-anatomical groups, display varying levels of maturation dependent on location. We reveal a previously underappreciated relationship between mesenchymal cancer cell states and age, linked to age-dependent differences in the immune microenvironment. Further, we resolve the spatial organization of H3-K27M DMG cell populations and identify a mitotic oligodendroglial-lineage niche. Collectively, our study provides a powerful framework for rational modeling and therapeutic interventions.
- Published
- 2022
- Full Text
- View/download PDF
44. Identifikation von kritischen Kontrollpunkten und Vorsorgemaßnahmen zur Absicherung der Öko-Integrität (Verbundvorhaben)
- Author
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Guhrke, Lena, Reusch, Babette, Neuerburg, Wolfgang, Beck, Alexander, Uthe, Pia, Neuendorff, Jochen, Roosen, Alix, Guhrke, Lena, Reusch, Babette, Neuerburg, Wolfgang, Beck, Alexander, Uthe, Pia, Neuendorff, Jochen, and Roosen, Alix
- Abstract
Das hier beschriebene Verbundvorhaben umfasst folgende Teilprojekte: FKZ 19OE001, FKZ 19OE145 Für die Bio-Branche gilt seit dem 01. Januar 2022 mit der Öko-Verordnung (EU) 2018/848 ein neuer Rechtsrahmen. Darin werden die Vorsorgepflichten zur „Vermeidung des Vorhan-denseins nicht zugelassener Erzeugnisse und Stoffe“ konkretisiert. Alle Bio-Unternehmen müssen ein Konzept erstellen, mit dem Risiken der Kontamination durch nicht zugelassene Erzeugnisse und Stoffe innerhalb des betrieblichen Verantwortungsbereiches systematisch erfasst und durch Vorsorgemaßnahmen vermieden werden. Im Verbundvorhaben wurden Praxisleitfäden und Arbeitshilfen entwickelt, welche den Unternehmen in den Bereichen Ökolandbau (inkl. Weinbau, Imkerei), Ökoverarbeitung und Handel/Import bei der Umsetzung dieser neuen Anforderungen Hilfestellung bieten. Die Praxisleitfäden geben einen Überblick über die neue Rechtslage und stellen dar, wie ein betriebliches Vorsorgekonzept gemäß den Anforderungen des Artikels 28 (1) umgesetzt werden kann. Die Arbeitshilfen zeigen relevante Risiken und mögliche Vorsorgemaßnah-men für verschiedene Branchen auf und bieten den Unternehmen ein qualifiziertes Werk-zeug, um das Vorsorgekonzept aufzustellen und zu dokumentieren. In Zusammenarbeit mit einer fachkundigen Juristin wurde weiterhin eine detaillierte und praxisnahe Rechts-auslegung zu Artikel 28 (1) der neuen EU-Öko-Verordnung erstellt. Über die Projektlaufzeit fand eine kontinuierliche Einbeziehung von Expert*innen aus Pra-xis, Beratung und Kontrolle statt. Die Projektergebnisse wurden auf https://orgprints.org/id/eprint/42876/ veröffentlicht und über diverse Fachveranstaltungen und einschlägige Medien weit verbreitet.
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- 2022
45. Optimization and Kinetic Modeling of a Fed-Batch Fermentation for Mannosylerythritol Lipids (MEL) Production With Moesziomyces aphidis
- Author
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Beck, Alexander, primary, Vogt, Franziska, additional, Hägele, Lorena, additional, Rupp, Steffen, additional, and Zibek, Susanne, additional
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- 2022
- Full Text
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46. Diseño, Construcción y Capacidades del Large Universal Shell Element Tester
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Demis Karagiannis, Dominik Werne, Walter Kaufmann, and Beck Alexander
- Subjects
elementos lámina ,solicitaciones combinadas ,hormigón estructural ,ensayos a gran escala ,Structural concrete ,large-scale experiments ,shell elements ,combined loading ,Computer science ,Shell element ,Mechanical engineering - Abstract
El Large Universal Shell Element Tester (LUSET) es un nuevo dispositivo de ensayos, desarrollado en la ETH Zúrich, el cual facilita el estudio del comportamiento mecánico, a escala real, de elementos lámina de hormigón armado sujetos a solicitaciones en sus tres dimensiones (esfuerzos combinados de elementos tipo losa y membrana). En este artículo se presentan los motivos que condujeron al desarrollo del LUSET y, adicionalmente, se describen sus componentes, el software de control y los sistemas de medición. Finalmente, se presenta una breve descripción de la serie de ensayos usada para validar la funcionalidad del LUSET, así como, un resumen de sus posibilidades., The Large Universal Shell Element Tester (LUSET) is a new testing facility that has been developed at ETH Zurich. It enables the investigation of the load-deformation behaviour of full-scale reinforced concrete shell elements under arbitrary loading conditions. The motivation for the development of the LUSET is outlined followed by a description of the hardware and software components of the setup and the measurement systems used. Finally, the test series for validating the functionality of the LUSET is discussed and a general overview of the facility’s overall testing capabilities is given., Hormigón y Acero, 73 (298), ISSN:0439-5689
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- 2022
- Full Text
- View/download PDF
47. Teilerneuerung Flughafentunnel: Rahmeneckversuche
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Beck, Alexander, Karrer, Simon, and Kaufmann, Walter
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Reinforced concrete ,Shear strength ,Frame corner ,Large scale experimental study - Abstract
Im Rahmen der statischen Überprüfungen des Flughafentunnels wurde in einigen Abschnitten eine ungenügende Schubtragfähigkeit der Riegelplatten im Bereich der Rahmenecken festgestellt. Da die Verhältnisse in diesen Platten infolge der Bewehrungsabstufung nicht durch die Tragwerksnormen abgedeckt werden und auch nicht mit vorhandenen Versuchen vergleichbar sind, wurden zwei Verifikationsversuche der Rahmenecken vorgeschlagen. Die Rahmeneckversuche sollten die Verhältnisse im realen Bauwerk möglichst realistisch nachbilden. Deshalb wurden Г-förmige Versuchskörper mit Voute im Massstab 1:1 nachgebaut und im Versuchslabor des IBK an der ETH Zürich getestet. Der Stiel der Rahmenecke wurde auf dem Aufspannboden aufgespannt. Der Kragarm, der einen Teil des Riegels repräsentierte, wurde durch zwei vertikale Kräfte belastet. Diese Kräfte wurden servohydraulisch mit je einem eigenen Kanal geregelt. Somit konnte eine beliebige M-V-Kombination in der Rahmenecke generiert werden. Das System des Flughafentunnels ist statisch unbestimmt. In einem horizontalen Abstand von rund 0.5 m zum Voutenanfang ist eine drastische Bewehrungsabstufung in der oberen Bewehrung der Riegelplatte vorhanden. Der sehr geringe geometrische Bewehrungsgehalt von 0.11 % auf der schwachen Seite der Abstufung führte dazu, dass im Versuch ein Schrägriss entstand, der von der Abstufung der Zuggurtbewehrung zum Voutenanfang verlief. Beim Reissen des Betons im Querschnitt der massiven Abstufung fand jeweils eine ausgeprägte Kräfteumlagerung statt, da die Fliessgrenze der schwachen oberen Bewehrung bei der Rissbildung überschritten wurde. In den Versuchen wurden die beiden Kräfte nach dem Reissen des Betons so geregelt, dass die Rissöffnung auf Zuggurthöhe konstant blieb und gleichzeitig die Querkraft im kritischen Querschnitt gesteigert werden konnte. Die Rissöffnung wurde beim ersten Versuch bei 2.45 mm und beim zweiten Versuch bei 1.25 mm konstant gehalten. Die Querkraft konnte nach dem Reissen des Betons in beiden Versuchen deutlich gesteigert werden. Beim ersten Versuch (FC1) wurde bei einer Rissöffnung von 2.45 mm eine über den Riss übertragene, auf die Breite b = 1.2 m sowie den Gurtabstand dv = 0.835 m bezogene mittlere Schubspannung von 0.88 MPa erreicht. Beim zweiten Versuch (FC2) konnte dieser Wert bei einer Rissöffnung von 1.25 mm auf 0.98 MPa gesteigert werden. Dabei wurde in beiden Versuchen wegen Kapazitätsbeschränkungen der Versuchsanlage tatsächlich kein Schubbruch erreicht. Die über den Schrägriss übertragene Querkraft hätte also unter Umständen noch weiter erhöht werden können. Im realen Bauwerk entstehen zudem, im Gegensatz zum Versuch, Membrandruckkräfte aus der Rahmenwirkung, die im Tragwerk günstig wirkend sind., IBK Bericht (507)
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- 2022
- Full Text
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48. Design, Construction and Capabilities of the Large Universal Shell Element Tester: Diseño, Construcción y Capacidades del Large Universal Shell Element Tester
- Author
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Kaufmann, Walter, Beck, Alexander, Karagiannis, Dimosthenis, and Werne, Dominik
- Subjects
Structural concrete ,shell elements ,combined loading ,large-scale experiments - Abstract
The Large Universal Shell Element Tester (LUSET) is a new testing facility that has been developed at ETH Zurich. It enables the investigation of the load-deformation behaviour of full-scale reinforced concrete shell elements under arbitrary loading conditions. The motivation for the development of the LUSET is outlined followed by a description of the hardware and software components of the setup and the measurement systems used. Finally, the test series for validating the functionality of the LUSET is discussed and a general overview of the facility’s overall testing capabilities is given.
- Published
- 2022
- Full Text
- View/download PDF
49. Praxisleitfäden für Bio-Unternehmen zur Umsetzung des Artikels 28 Absatz 1 der Öko-Verordnung (EU) 2018/848
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Guhrke, Lena, Reusch, Babette, Neuerburg, Wolfgang, Uthe, Pia, Beck, Alexander, Neuendorff, Jochen, Roosen, Alix, and Borges, Heike
- Subjects
Food security, food quality and human health ,Markets and trade ,Crop husbandry ,Education, extension and communication ,"Organics" in general ,Processing, packaging and transportation ,Animal husbandry ,Assessment of impacts and risks - Abstract
Im Rahmen des durch das Bundesprogramm Ökologischer Landbau und andere Formen nachhaltiger Landwirtschaft (BÖLN) geförderten Verbundvorhabens „Identifikation von kritischen Kontrollpunkten und Vorsorgemaßnahmen zur Absicherung der Öko-Integrität (BioKKP)“ (FKZ 2819OE001, 2819OE145) wurden vier Praxisleitfäden sowie weitere Arbeitshilfen erstellt. Diese sollen Bio-Unternehmen in den Bereichen Landwirtschaft, Lebens- und Futtermittelverarbeitung sowie Handel und Import bei der praktischen Umsetzung der Vorgaben des Artikels 28 (1) der Öko-Verordnung (EU) 2018/848 unterstützen. Die Leitfäden und Arbeitshilfen geben einen Überblick über: • die neue Rechtslage, • die unternehmerischen Pflichten zur Umsetzung von Vorsorgemaßnahmen, • eine praxisnahe Anleitung zur Umsetzung eines betriebsindividuellen „Vorsorgekonzeptes“, • relevante Risiken und entsprechende Vorsorgemaßnahmen in den unterschiedlichen Unternehmensbereichen, • Praxisbeispiele aus den verschiedenen Unternehmensbereichen. Einen detaillierten Überblick zur rechtlichen Auslegung des Artikels 28 (1) gibt das Rechtsauslegungsdokument.
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- 2021
50. Assessment Framework for the Evaluation of Organic Food Processing
- Author
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Meier, Matthias, Bickel, Regula, Beck, Alexander, and Stumpner, Johanna
- Subjects
"Organics" in general ,Processing, packaging and transportation ,ComputingMilieux_MISCELLANEOUS - Abstract
Processors having no experience in organic food processing may be not aware tha organic principles are not only relevant in organic production but also apply for the processing of organic food. In contrast, if processors are thinking about investments in new processing technologies or are planning to process organic food and want to evaluate whether the new processing technology or their existing processing technologies comply with the organic principles, they are quickly struggling today to come to a meaningful result as the present regulatory framework does not provide conclusive guidance on organic food processing.
- Published
- 2021
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