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2. 4-1BBL–containing leukemic extracellular vesicles promote immunosuppressive effector regulatory T cells

Author

Swatler, Julian, Turos-Korgul, Laura, Brewinska-Olchowik, Marta, De Biasi, Sara, Dudka, Wioleta, Le, Bac Viet, Kominek, Agata, Cyranowski, Salwador, Pilanc, Paulina, Mohammadi, Elyas, Cysewski, Dominik, Kozlowska, Ewa, Grabowska-Pyrzewicz, Wioleta, Wojda, Urszula, Basak, Grzegorz, Mieczkowski, Jakub, Skorski, Tomasz, Cossarizza, Andrea, and Piwocka, Katarzyna

Published
2022
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3. Prevalence of hypogammaglobulinemia and its management with subcutaneous immunoglobulin supplementation in patients after allogeneic hematopoietic stem cell transplantation—a single-center analysis

Author

Karakulska-Prystupiuk, Ewa, Dwilewicz-Trojaczek, Jadwiga, Drozd-Sokołowska, Joanna, Kmin, Ewelina, Chlebus, Marcin, Szczypińska, Karolina, Boguradzki, Piotr, Tomaszewska, Agnieszka, Mądry, Krzysztof, Biliński, Jarosław, Basak, Grzegorz Władysław, and Jędrzejczak, Wiesław Wiktor

Published
2021
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4. Advancement and Challenges in Monitoring of CAR-T Cell Therapy: A Comprehensive Review of Parameters and Markers in Hematological Malignancies.

Author

Ploch, Weronika, Sadowski, Karol, Olejarz, Wioletta, and Basak, Grzegorz W.

Subjects
CEREBROSPINAL fluid examination, IMMUNIZATION, FLOW cytometry, BONE marrow examination, HEMATOLOGIC malignancies, IMMUNOTHERAPY, POLYMERASE chain reaction, TREATMENT effectiveness, TUMOR markers, PATIENT monitoring, CYTOKINES, INDIVIDUALIZED medicine, DISEASE progression
Abstract

Simple Summary: Chimeric antigen receptor T-cell (CAR-T) therapy has revolutionized the treatment of hematological malignancies but is often associated with significant adverse events. As these events affect up to 80% of patients, they constitute a crucial problem to overcome. This review focuses on the monitoring process of CAR-T cell therapy including the monitoring of the persistence, activity, and phenotyping of the cells. The implementation of tools like flow cytometry and polymerase chain reaction provides insights into cellular responses, enabling the optimization of CAR-T cell therapy for more precise and personalized treatment and addressing the challenge of tumor relapse. Chimeric antigen receptor T-cell (CAR-T) therapy has revolutionized the treatment for relapsed/refractory B-cell lymphomas. Despite its success, this therapy is accompanied by a significant frequency of adverse events, including cytokine release syndrome (CRS), immune-effector-cell-associated neurotoxicity syndrome (ICANS), or cytopenias, reaching even up to 80% of patients following CAR-T cell therapy. CRS results from the uncontrolled overproduction of proinflammatory cytokines, which leads to symptoms such as fever, headache, hypoxia, or neurological complications. CAR-T cell detection is possible by the use of flow cytometry (FC) or quantitative polymerase chain reaction (qPCR) assays, the two primary techniques used for CAR-T evaluation in peripheral blood, bone marrow (BM), and cerebrospinal fluid (CSF). State-of-the-art imaging technologies play a crucial role in monitoring the distribution and persistence of CAR-T cells in clinical trials. Still, they can also be extended with the use of FC and digital PCR (dPCR). Monitoring the changes in cell populations during disease progression and treatment gives an important insight into how the response to CAR-T cell therapy develops on a cellular level. It can help improve the therapeutic design and optimize CAR-T cell therapy to make it more precise and personalized, which is crucial to overcoming the problem of tumor relapse. [ABSTRACT FROM AUTHOR]

Published
2024
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7. Allogeneic Hematopoietic Stem Cell Transplantation for Paroxysmal Nocturnal Hemoglobinuria: Multicenter Analysis by the Polish Adult Leukemia Group

Author

Markiewicz, Miroslaw, Drozd-Sokolowska, Joanna, Biecek, Przemyslaw, Dzierzak-Mietla, Monika, Boguradzki, Piotr, Staniak, Mateusz, Piatkowska-Jakubas, Beata, Piekarska, Agnieszka, Tormanowska, Magdalena, Halaburda, Kazimierz, Ussowicz, Marek, Waszczuk-Gajda, Anna, Basak, Grzegorz, Bołkun, Lukasz, Rybka, Justyna, Sadus-Wojciechowska, Maria, Giebel, Sebastian, Szmigielska-Kaplon, Anna, Mendek-Czajkowska, Ewa, Warzybok, Katarzyna, Burdacki, Adrian, and Dwilewicz-Trojaczek, Jadwiga

Published
2020
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10. Potent but transient immunosuppression of T-cells is a general feature of CD71+ erythroid cells

Author

Grzywa, Tomasz M., Sosnowska, Anna, Rydzynska, Zuzanna, Lazniewski, Michal, Plewczynski, Dariusz, Klicka, Klaudia, Malecka-Gieldowska, Milena, Rodziewicz-Lurzynska, Anna, Ciepiela, Olga, Justyniarska, Magdalena, Pomper, Paulina, Grzybowski, Marcin M., Blaszczyk, Roman, Wegrzynowicz, Michal, Tomaszewska, Agnieszka, Basak, Grzegorz, Golab, Jakub, and Nowis, Dominika

Published
2021
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11. IDH2 mutations in patients with normal karyotype AML predict favorable responses to daunorubicin, cytarabine and cladribine regimen

Author

Libura, Marta, Bialopiotrowicz, Emilia, Giebel, Sebastian, Wierzbowska, Agnieszka, Roboz, Gail J., Piatkowska-Jakubas, Beata, Pawelczyk, Marta, Gorniak, Patryk, Borg, Katarzyna, Wojtas, Magdalena, Florek, Izabella, Matiakowska, Karolina, Jazwiec, Bozena, Solarska, Iwona, Noyszewska-Kania, Monika, Piechna, Karolina, Zawada, Magdalena, Czekalska, Sylwia, Salamanczuk, Zoriana, Karabin, Karolina, Wasilewska, Katarzyna, Paluszewska, Monika, Urbanowska, Elzbieta, Gajkowska-Kulik, Justyna, Semenczuk, Grazyna, Rybka, Justyna, Wrobel, Tomasz, Ejduk, Anna, Kata, Dariusz, Grosicki, Sebastian, Robak, Tadeusz, Pluta, Agnieszka, Kominek, Agata, Piwocka, Katarzyna, Pyziak, Karolina, Sroka-Porada, Agnieszka, Wrobel, Anna, Przybylowicz, Agnieszka, Wojtaszewska, Marzena, Lewandowski, Krzysztof, Gil, Lidia, Piekarska, Agnieszka, Knopinska, Wanda, Bolkun, Lukasz, Warzocha, Krzysztof, Kuliczkowski, Kazimierz, Sacha, Tomasz, Basak, Grzegorz, Jedrzejczak, Wieslaw Wiktor, Holowiecki, Jerzy, Juszczynski, Przemysław, and Haus, Olga

Published
2021
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12. Gonadal Function after Busulfan Compared with Treosulfan in Children and Adolescents Undergoing Allogeneic Hematopoietic Stem Cell Transplant

Author

Faraci, Maura, Diesch, Tamara, Labopin, Myriam, Dalissier, Arnaud, Lankester, Arian, Gennery, Andrew, Sundin, Mikael, Uckan-Cetinkaya, Duygu, Bierings, Marc, Peters, Anke M.J., Garwer, Martina, Schulz, Ansgar, Michel, Gerard, Giorgiani, Giovanna, Gruhn, Bernd, Locatelli, Franco, Giardino, Stefano, Uyttebroeck, Anne, Rialland, Fanny, Itäla-Remes, Maija, Dreger, Peter, Shaw, Peter J., Bordon, Victoria, Schlegel, Paul G., Mellgren, Karin, Moraleda, Jose M., Patrick, Katharine, Schneider, Pascale, Jubert, Charlotte, Lawitschka, Anita, Salooja, Nina, Basak, Grzegorz W., Corbacioglu, Selim, Duarte, Rafael, and Bader, Peter

Published
2019
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14. Non-Graft-versus-Host Disease Ocular Complications after Hematopoietic Cell Transplantation: Expert Review from the Late Effects and Quality of Life Working Committee of the Center for International Blood and Marrow Transplant Research and the Transplant Complications Working Party of the European Society for Blood and Marrow Transplantation

Author

Inamoto, Yoshihiro, Petriček, Igor, Burns, Linda, Chhabra, Saurabh, DeFilipp, Zachariah, Hematti, Peiman, Rovó, Alicia, Schears, Raquel, Shah, Ami, Agrawal, Vaibhav, Ahmed, Aisha, Ahmed, Ibrahim, Ali, Asim, Aljurf, Mahmoud, Alkhateeb, Hassan, Beitinjaneh, Amer, Bhatt, Neel, Buchbinder, Dave, Byrne, Michael, Callander, Natalie, Fahnehjelm, Kristina, Farhadfar, Nosha, Gale, Robert Peter, Ganguly, Siddhartha, Hashmi, Shahrukh, Hildebrandt, Gerhard C., Horn, Erich, Jakubowski, Ann, Kamble, Rammurti T., Law, Jason, Lee, Catherine, Nathan, Sunita, Penack, Olaf, Pingali, Ravi, Prasad, Pinki, Pulanic, Drazen, Rotz, Seth, Shreenivas, Aditya, Steinberg, Amir, Tabbara, Khalid, Tichelli, André, Wirk, Baldeep, Yared, Jean, Basak, Grzegorz W., Battiwalla, Minoo, Duarte, Rafael, Savani, Bipin N., Flowers, Mary E.D., Shaw, Bronwen E., and Valdés-Sanz, Nuria

Published
2019
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15. Ocular Graft-versus-Host Disease after Hematopoietic Cell Transplantation: Expert Review from the Late Effects and Quality of Life Working Committee of the Center for International Blood and Marrow Transplant Research and Transplant Complications Working Party of the European Society of Blood and Marrow Transplantation

Author

Inamoto, Yoshihiro, Valdés-Sanz, Nuria, Ogawa, Yoko, Alves, Monica, Berchicci, Luigi, Galvin, John, Greinix, Hildegard, Hale, Gregory A., Horn, Biljana, Kelly, Debra, Liu, Hien, Rowley, Scott, Schoemans, Helene, Shah, Ami, Lupo Stanghellini, Maria Teresa, Agrawal, Vaibhav, Ahmed, Ibrahim, Ali, Asim, Bhatt, Neel, Byrne, Michael, Chhabra, Saurabh, DeFilipp, Zachariah, Fahnehjelm, Kristina, Farhadfar, Nosha, Horn, Erich, Lee, Catherine, Nathan, Sunita, Penack, Olaf, Prasad, Pinki, Rotz, Seth, Rovó, Alicia, Yared, Jean, Pavletic, Steven, Basak, Grzegorz W., Battiwalla, Minoo, Duarte, Rafael, Savani, Bipin N., Flowers, Mary E.D., Shaw, Bronwen E., and Petriček, Igor

Published
2019
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16. Endothelial Activation and Stress Index (EASIX) to predict mortality after allogeneic stem cell transplantation: a prospective study

Author

Penack, Olaf, primary, Luft, Thomas, additional, Peczynski, Christophe, additional, Benner, Axel, additional, Sica, Simona, additional, Arat, Mutlu, additional, Itäla-Remes, Maija, additional, Corral, Lucia López, additional, Schaap, Nicolaas P M, additional, Karas, Michal, additional, Raida, Ludek, additional, Schroeder, Thomas, additional, Dreger, Peter, additional, Metafuni, Elisabetta, additional, Ozcelik, Tulay, additional, Sandmaier, Brenda M, additional, Kordelas, Lambros, additional, Moiseev, Ivan, additional, Schoemans, Hélène, additional, Koenecke, Christian, additional, Basak, Grzegorz W, additional, and Peric, Zinaida, additional

Published
2024
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17. Advancements in Personalized CAR-T Therapy: Comprehensive Overview of Biomarkers and Therapeutic Targets in Hematological Malignancies.

Author

Olejarz, Wioletta, Sadowski, Karol, Szulczyk, Daniel, and Basak, Grzegorz

Subjects
HEMATOLOGIC malignancies, DRUG resistance in cancer cells, CYTOKINE release syndrome, BIOMARKERS, DRUG target
Abstract

Chimeric antigen receptor T-cell (CAR-T) therapy is a novel anticancer therapy using autologous or allogeneic T-cells. To date, six CAR-T therapies for specific B-cell acute lymphoblastic leukemia (B-ALL), non-Hodgkin lymphomas (NHL), and multiple myeloma (MM) have been approved by the Food and Drug Administration (FDA). Significant barriers to the effectiveness of CAR-T therapy include cytokine release syndrome (CRS), neurotoxicity in the case of Allogeneic Stem Cell Transplantation (Allo-SCT) graft-versus-host-disease (GVHD), antigen escape, modest antitumor activity, restricted trafficking, limited persistence, the immunosuppressive microenvironment, and senescence and exhaustion of CAR-Ts. Furthermore, cancer drug resistance remains a major problem in clinical practice. CAR-T therapy, in combination with checkpoint blockades and bispecific T-cell engagers (BiTEs) or other drugs, appears to be an appealing anticancer strategy. Many of these agents have shown impressive results, combining efficacy with tolerability. Biomarkers like extracellular vesicles (EVs), cell-free DNA (cfDNA), circulating tumor (ctDNA) and miRNAs may play an important role in toxicity, relapse assessment, and efficacy prediction, and can be implicated in clinical applications of CAR-T therapy and in establishing safe and efficacious personalized medicine. However, further research is required to fully comprehend the particular side effects of immunomodulation, to ascertain the best order and combination of this medication with conventional chemotherapy and targeted therapies, and to find reliable predictive biomarkers. [ABSTRACT FROM AUTHOR]

Published
2024
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18. No advantage of antimicrobial prophylaxis in AML/MDS/CMML patients treated with azacitidine --a prospective multicenter study by the Polish Adult Leukemia Group.

Author

Mądry, Krzysztof, Lis, Karol, Sienkiewicz, Elzbieta, Drozd-Sokołowska, Joanna, Biecek, Przemysław, Sośnia, Oktawia, Gołos, Aleksandra, Olszewska-Szopa, Magdalena, Obara, Agata, Walkowiak, Zuzanna, Ściesińska, Joanna, Subocz, Edyta, Butrym, Aleksandra, Machowicz, Rafał, Budziszewska, Katarzyna, and Basak, Grzegorz

Subjects
AZACITIDINE, ACUTE myeloid leukemia, ERYTHROCYTES, LEUKEMIA, PREVENTIVE medicine
Abstract

Introduction: Infections represent one of the most frequent causes of death of higher-risk MDS patients, as reported previously also by our group. Azacitidine Infection Risk Model (AIR), based on red blood cell (RBC) transfusion dependency, neutropenia <0.8 x 109/L, platelet count <50 x 109/L, albumin <35g/L, and ECOG performance status ≥2 has been proposed based on the retrospective data to estimate the risk of infection in azacitidine treated patients. Methods: The prospective non-intervention study aimed to identify factors predisposing to infection, validate the AIR score, and assess the impact of antimicrobial prophylaxis on the outcome of azacitidine-treated MDS/AML and CMML patients. Results: We collected data on 307 patients, 57.6 % males, treated with azacitidine: AML (37.8%), MDS (55.0%), and CMML (7.1%). The median age at azacitidine treatment commencement was 71 (range, 18-95) years. 200 (65%) patients were assigned to higher risk AIR group. Antibacterial, antifungal, and antiviral prophylaxis was used in 66.0%, 29.3%, and 25.7% of patients, respectively. In total, 169 infectious episodes (IE) were recorded in 118 (38.4%) patients within the first three azacitidine cycles. In a multivariate analysis ECOG status, RBC transfusion dependency, IPSS-R score, and CRP concentration were statistically significant for infection development (p < 0.05). The occurrence of infection within the first three azacitidine cycles was significantly higher in the higher risk AIR group -- 47.0% than in lower risk 22.4% (odds ratio (OR) 3.06; 95% CI 1.82-5.30, p < 0.05). Administration of antimicrobial prophylaxis did not have a significant impact on all-infection occurrence in multivariate analysis: antibacterial prophylaxis (OR 0.93; 0.41-2.05, p = 0.87), antifungal OR 1.24 (0.54-2.85) (p = 0.59), antiviral OR 1.24 (0.53-2.82) (p = 0.60). Discussion: The AIR Model effectively discriminates infection-risk patients during azacitidine treatment. Antimicrobial prophylaxis does not decrease the infection rate. [ABSTRACT FROM AUTHOR]

Published
2024
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19. ECP versus ruxolitinib in steroid-refractory acute GVHD – a retrospective study by the EBMT transplant complications working party

Author

Penack, Olaf, primary, Peczynski, Christophe, additional, Boreland, William, additional, Lemaitre, Jessica, additional, Afanasyeva, Ksenia, additional, Kornblit, Brian, additional, Jurado, Manuel, additional, Martinez, Carmen, additional, Natale, Annalisa, additional, Pérez-Simón, Jose Antonio, additional, Brunello, Lucia, additional, Avenoso, Daniele, additional, Klein, Stefan, additional, Ozkurt, Zubeyde Nur, additional, Herrera, Concha, additional, Wichert, Stina, additional, Chiusolo, Patrizia, additional, Gavriilaki, Eleni, additional, Basak, Grzegorz W., additional, Schoemans, Hélène, additional, Koenecke, Christian, additional, Moiseev, Ivan, additional, and Peric, Zinaida, additional

Published
2023
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21. Prognostic Impact of Copy Number Alterations’ Profile and AID/RAG Signatures in Acute Lymphoblastic Leukemia (ALL) with BCR::ABL and without Recurrent Genetic Aberrations (NEG ALL) Treated with Intensive Chemotherapy

Author

Libura, Marta, primary, Karabin, Karolina, additional, Tyrna, Paweł, additional, Czyż, Anna, additional, Makuch-Łasica, Hanna, additional, Jaźwiec, Bożena, additional, Paluszewska, Monika, additional, Piątkowska-Jakubas, Beata, additional, Zawada, Magdalena, additional, Gniot, Michał, additional, Trubicka, Joanna, additional, Szymańska, Magdalena, additional, Borg, Katarzyna, additional, Więsik, Marta, additional, Czekalska, Sylwia, additional, Florek, Izabela, additional, Król, Maria, additional, Paszkowska-Kowalewska, Małgorzata, additional, Gil, Lidia, additional, Kapelko-Słowik, Katarzyna, additional, Patkowska, Elżbieta, additional, Tomaszewska, Agnieszka, additional, Mądry, Krzysztof, additional, Machowicz, Rafał, additional, Czerw, Tomasz, additional, Piekarska, Agnieszka, additional, Dutka, Magdalena, additional, Kopińska, Anna, additional, Helbig, Grzegorz, additional, Gromek, Tomasz, additional, Lewandowski, Krzysztof, additional, Zacharczuk, Marta, additional, Pastwińska, Anna, additional, Wróbel, Tomasz, additional, Haus, Olga, additional, Basak, Grzegorz, additional, Hołowiecki, Jerzy, additional, Juszczyński, Przemysław, additional, Lech-Marańda, Ewa, additional, Giebel, Sebastian, additional, and Jędrzejczak, Wiesław Wiktor, additional

Published
2023
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24. Neurocognitive Dysfunction in Hematopoietic Cell Transplant Recipients: Expert Review from the Late Effects and Quality of Life Working Committee of the Center for International Blood and Marrow Transplant Research and Complications and Quality of Life Working Party of the European Society for Blood and Marrow Transplantation

Author

Kelly, Debra Lynch, Buchbinder, David, Duarte, Rafael F., Auletta, Jeffrey J., Bhatt, Neel, Byrne, Michael, DeFilipp, Zachariah, Gabriel, Melissa, Mahindra, Anuj, Norkin, Maxim, Schoemans, Helene, Shah, Ami J., Ahmed, Ibrahim, Atsuta, Yoshiko, Basak, Grzegorz W., Beattie, Sara, Bhella, Sita, Bredeson, Christopher, Bunin, Nancy, Dalal, Jignesh, Daly, Andrew, Gajewski, James, Gale, Robert Peter, Galvin, John, Hamadani, Mehdi, Hayashi, Robert J., Adekola, Kehinde, Law, Jason, Lee, Catherine J., Liesveld, Jane, Malone, Adriana K., Nagler, Arnon, Naik, Seema, Nishihori, Taiga, Parsons, Susan K., Scherwath, Angela, Schofield, Hannah-Lise, Soiffer, Robert, Szer, Jeff, Twist, Ida, Warwick, Anne, Wirk, Baldeep M., Yi, Jean, Battiwalla, Minoo, Flowers, Mary E., Savani, Bipin, and Shaw, Bronwen E.

Published
2018
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25. Male-Specific Late Effects in Adult Hematopoietic Cell Transplantation Recipients: A Systematic Review from the Late Effects and Quality of Life Working Committee of the Center for International Blood and Marrow Transplant Research and Transplant Complications Working Party of the European Society of Blood and Marrow Transplantation

Author

Phelan, Rachel, Im, Annie, Hunter, Rebecca L., Inamoto, Yoshihiro, Lupo-Stanghellini, Maria Teresa, Rovo, Alicia, Badawy, Sherif M., Burns, Linda, Eissa, Hesham, Murthy, Hemant S., Prasad, Pinki, Sharma, Akshay, Suelzer, Elizabeth, Agrawal, Vaibhav, Aljurf, Mahmoud, Baker, Karen, Basak, Grzegorz W., Buchbinder, David, DeFilipp, Zachariah, Grkovic, Lana Desnica, Dias, Ajoy, Einsele, Hermann, Eisenberg, Michael L., Epperla, Narendranath, Farhadfar, Nosha, Flatau, Arthur, Gale, Robert Peter, Greinix, Hildegard, Hamilton, Betty K., Hashmi, Shahrukh, Hematti, Peiman, Jamani, Kareem, Maharaj, Dipnarine, Murray, John, Naik, Seema, Nathan, Sunita, Pavletic, Steven, Peric, Zinaida, Pulanic, Drazen, Ross, Richard, Salonia, Andrea, Sanchez-Ortega, Isabel, Savani, Bipin N., Schechter, Tal, Shah, Ami J., Smith, Stephanie M., Snowden, John A., Steinberg, Amir, Tremblay, Douglas, Vij, Sarah C., Walker, Lauren, Wolff, Daniel, Yared, Jean A., Schoemans, Hélène, and Tichelli, André

Published
2022
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26. Age-dependent determinants of infectious complications profile in children and adults after hematopoietic cell transplantation: lesson from the nationwide study

Author

Czyżewski, Krzysztof, Styczyński, Jan, Giebel, Sebastian, Frączkiewicz, Jowita, Salamonowicz, Małgorzata, Zając-Spychala, Olga, Zaucha-Prażmo, Agnieszka, Drozd-Sokołowska, Joanna, Waszczuk-Gajda, Anna, Dybko, Jarosław, Mańko, Joanna, Zalas-Więcek, Patrycja, Gałązka, Przemysław, Wysocki, Mariusz, Kowalczyk, Jerzy, Wachowiak, Jacek, Goździk, Jolanta, Basak, Grzegorz W, Kałwak, Krzysztof, Adamska, Monika, Hus, Marek, Piekarska, Agnieszka, Sadowska-Klasa, Alicja, Mensah-Glanowska, Patrycja, Kyrcz-Krzemień, Sławomira, Biernat, Monika, Wierzbowska, Agnieszka, Rzepecki, Piotr, Tomaszewska, Agnieszka, Hałaburda, Kazimierz, Gil, Lidia, and for Polish Society of Pediatric Oncology and Hematology and Polish Society of Hematology and Blood Transfusion

Published
2019
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27. European experience and risk factor analysis of donor cell-derived leukaemias/MDS following haematopoietic cell transplantation

Author

Engel, Nicole, Rovo, Alicia, Badoglio, Manuela, Labopin, Myriam, Basak, Grzegorz W., Beguin, Yves, Guyotat, Denis, Ljungman, Per, Nagler, Arnon, Schattenberg, Anton, Schroeder, Thomas, Schroyens, Wilfried, Tischer, Johanna, Socie, Gerard, Kolb, Hans-Jochem, Tichelli, Andre, Salooja, Nina, Duarte, Rafael F., and for the Transplant Complications Working Party of the European Society for Blood and Marrow Transplantation

Published
2019
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28. ROR1 Is Expressed in Human Breast Cancer and Associated with Enhanced Tumor-Cell Growth

Author

Zhang, Suping, Chen, Liguang, Cui, Bing, Chuang, Han-Yu, Yu, Jianqiang, Wang-Rodriguez, Jessica, Tang, Li, Chen, George, Basak, Grzegorz W, and Kipps, Thomas J

Subjects
Biochemistry and Cell Biology, Biomedical and Clinical Sciences, Oncology and Carcinogenesis, Biological Sciences, Women's Health, Breast Cancer, Cancer, 2.1 Biological and endogenous factors, Animals, Antibodies, Monoclonal, Antibody Specificity, Breast Neoplasms, CHO Cells, Cell Proliferation, Cell Survival, Cricetinae, Cricetulus, Cyclic AMP Response Element-Binding Protein, Enzyme Activation, Female, Gene Expression Regulation, Neoplastic, Humans, Mice, Middle Aged, Phosphatidylinositol 3-Kinases, Proto-Oncogene Proteins, Proto-Oncogene Proteins c-akt, Receptor Tyrosine Kinase-like Orphan Receptors, Signal Transduction, Wnt Proteins, Wnt-5a Protein, General Science & Technology
Abstract

Receptor-tyrosine-kinase-like orphan receptor 1 (ROR1) is expressed during embryogenesis and by certain leukemias, but not by normal adult tissues. Here we show that the neoplastic cells of many human breast cancers express the ROR1 protein and high-level expression of ROR1 in breast adenocarcinoma was associated with aggressive disease. Silencing expression of ROR1 in human breast cancer cell lines found to express this protein impaired their growth in vitro and also in immune-deficient mice. We found that ROR1 could interact with casein kinase 1 epsilon (CK1ε) to activate phosphoinositide 3-kinase-mediated AKT phosphorylation and cAMP-response-element-binding protein (CREB), which was associated with enhanced tumor-cell growth. Wnt5a, a ligand of ROR1, could induce ROR1-dependent signaling and enhance cell growth. This study demonstrates that ROR1 is expressed in human breast cancers and has biological and clinical significance, indicating that it may be a potential target for breast cancer therapy.

Published
2012

30. Significance of HLA-E and its two NKG2 receptors in development of complications after allogeneic transplantation of hematopoietic stem cells

Author

Siemaszko, Jagoda, primary, Łacina, Piotr, additional, Szymczak, Donata, additional, Szeremet, Agnieszka, additional, Majcherek, Maciej, additional, Czyż, Anna, additional, Sobczyk-Kruszelnicka, Małgorzata, additional, Fidyk, Wojciech, additional, Solarska, Iwona, additional, Nasiłowska-Adamska, Barbara, additional, Skowrońska, Patrycja, additional, Bieniaszewska, Maria, additional, Tomaszewska, Agnieszka, additional, Basak, Grzegorz W., additional, Giebel, Sebastian, additional, Wróbel, Tomasz, additional, and Bogunia-Kubik, Katarzyna, additional

Published
2023
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32. Organ complications after CD19 CAR T-cell therapy for large B cell lymphoma: a retrospective study from the EBMT transplant complications and lymphoma working party

Author

Penack, Olaf, primary, Peczynski, Christophe, additional, Koenecke, Christian, additional, Polge, Emmanuelle, additional, Sanderson, Robin, additional, Yakoub-Agha, Ibrahim, additional, Fegueux, Nathalie, additional, Daskalakis, Michael, additional, Collin, Matthew, additional, Dreger, Peter, additional, Kröger, Nicolaus, additional, Schanz, Urs, additional, Bloor, Adrian, additional, Ganser, Arnold, additional, Besley, Caroline, additional, Wulf, Gerald G., additional, Novak, Urban, additional, Moiseev, Ivan, additional, Schoemans, Hélène, additional, Basak, Grzegorz W., additional, Chabannon, Christian, additional, Sureda, Anna, additional, Glass, Bertram, additional, and Peric, Zinaida, additional

Published
2023
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34. PB1999: TOBACCO SMOKING IN MDS PATIENTS – ANALYSIS FROM THE MDS PALG REGISTRY

Author

Machowicz, Rafal, primary, Lis, Karol, additional, Rytel, Jagoda, additional, Jachalska, Anna, additional, Szwedyk, Pawel, additional, Sosnia, Oktawia, additional, Wiater, Elzbieta, additional, Obara, Agata, additional, Krochmalczyk, Dorota, additional, Kopinska, Anna, additional, Gajewska, Malgorzata, additional, Masternak, Anna, additional, Kopacz, Agnieszka, additional, Olszewska-Szopa, Magdalena, additional, Golos, Aleksandra, additional, Subocz, Edyta, additional, Drozd-Sokolowska, Joanna, additional, Basak, Grzegorz, additional, and Mądry, Krzysztof, additional

Published
2023
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35. The Real-World Evidence on the Fragility and Its Impact on the Choice of Treatment Regimen in Newly Diagnosed Patients with Multiple Myeloma over 75 Years of Age

Author

Tyczyńska, Agata, primary, Krzempek, Marcela Krzysława, additional, Cortez, Alexander Jorge, additional, Jurczyszyn, Artur, additional, Godlewska, Katarzyna, additional, Ciepłuch, Hanna, additional, Subocz, Edyta, additional, Hałka, Janusz, additional, Kulikowska de Nałęcz, Anna, additional, Wiśniewska, Anna, additional, Świderska, Alina, additional, Waszczuk-Gajda, Anna, additional, Drozd-Sokołowska, Joanna, additional, Guzicka-Kazimierczak, Renata, additional, Wiśniewski, Kamil, additional, Porowska, Agnieszka, additional, Knopińska-Posłuszny, Wanda, additional, Kłoczko, Janusz, additional, Rzepecki, Piotr, additional, Woszczyk, Dariusz, additional, Symonowicz, Hanna, additional, Basak, Grzegorz Władysław, additional, Zdziarska, Barbara, additional, Jamroziak, Krzysztof, additional, and Zaucha, Jan M., additional

Published
2023
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36. Supporting the Diagnosis of Fabry Disease Using a Natural Language Processing-Based Approach

Author

Michalski, Adrian A., primary, Lis, Karol, additional, Stankiewicz, Joanna, additional, Kloska, Sylwester M., additional, Sycz, Arkadiusz, additional, Dudziński, Marek, additional, Muras-Szwedziak, Katarzyna, additional, Nowicki, Michał, additional, Bazan-Socha, Stanisława, additional, Dabrowski, Michal J., additional, and Basak, Grzegorz W., additional

Published
2023
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38. Current incidence, severity, and management of veno-occlusive disease/sinusoidal obstruction syndrome in adult allogeneic HSCT recipients:an EBMT Transplant Complications Working Party study

Author

Ruutu, Tapani, Peczynski, Christophe, Houhou, Mohamed, Polge, Emmanuelle, Mohty, Mohamad, Kröger, Nicolaus, Moiseev, Ivan, Penack, Olaf, Salooja, Nina, Schoemans, Hélène, Duarte, Rafael F., Schroeder, Thomas, Passweg, Jakob, Wulf, Gerald G., Ganser, Arnold, Sica, Simona, Arat, Mutlu, Salmenniemi, Urpu, Broers, Annoek E.C., Bourhis, Jean Henri, Rambaldi, Alessandro, Maertens, Johan, Halaburda, Kazimierz, Zuckerman, Tsila, Labussière-Wallet, Hélène, Basak, Grzegorz, Koenecke, Christian, Perić, Zinaida, Ruutu, Tapani, Peczynski, Christophe, Houhou, Mohamed, Polge, Emmanuelle, Mohty, Mohamad, Kröger, Nicolaus, Moiseev, Ivan, Penack, Olaf, Salooja, Nina, Schoemans, Hélène, Duarte, Rafael F., Schroeder, Thomas, Passweg, Jakob, Wulf, Gerald G., Ganser, Arnold, Sica, Simona, Arat, Mutlu, Salmenniemi, Urpu, Broers, Annoek E.C., Bourhis, Jean Henri, Rambaldi, Alessandro, Maertens, Johan, Halaburda, Kazimierz, Zuckerman, Tsila, Labussière-Wallet, Hélène, Basak, Grzegorz, Koenecke, Christian, and Perić, Zinaida

Abstract

The current incidence, diagnostic policy, management, and outcome of VOD/SOS at EBMT centers were studied. All centers that had performed allogeneic HSCTs in adult patients within one defined year were invited to the study. Seventy-one centers participated with a total of 2886 allogeneic transplantations and 93 cases of VOD/SOS in 2018. The cumulative incidence of VOD/SOS at day 21 was 1.8% and at day 100 2.4%. Of 67 cases with detailed data, 52 were classical and 15 (22%) late onset (>day 21). According to the EBMT criteria, 65/67 patients had at least two VOD/SOS risk factors. The severity grades were: mild 0, moderate 3, severe 29, very severe 35. Fifty-four patients were treated with defibrotide. VOD/SOS resolved in 58% of the patients, 3/3 with moderate, 22/28 with severe, and 12/33 with very severe grade (p < 0.001). By day 100, 57% of the patients were alive; 3/3 with moderate, 22/29 with severe, and 13/35 with very severe VOD/SOS (p = 0.002). In conclusion, the incidence of VOD/SOS was low. Severe and very severe grades dominated. Very severe grade predicted poor outcome compared to severe grade further supporting the concept of early diagnosis and treatment to avoid a dismal outcome. [Figure not available: see fulltext.]

Published
2023

39. ECP versus ruxolitinib in steroid-refractory acute GVHD – a retrospective study by the EBMT transplant complications working party

Author

German Research Foundation, German Cancer Aid, Stiftung Charité, Penack, Olaf, Peczynski, Christophe, Boreland, William, Lemaitre, Jessica, Afanasyeva, Ksenia, Kornblit, Brian, Jurado, Manuel, Martínez, Carmen, Natale, Annalisa, Pérez-Simón, José A., Brunello, Lucia, Avenoso, Daniele, Klein, Stefan, Ozkurt, Zubeyde Nur, Herrera, Concha, Wichert, Stina, Chiusolo, Patrizia, Gavriilaki, Eleni, Basak, Grzegorz W., Schoemans, Hélène, Koenecke, Christian, Moiseev, Ivan, Peric, Zinaida, German Research Foundation, German Cancer Aid, Stiftung Charité, Penack, Olaf, Peczynski, Christophe, Boreland, William, Lemaitre, Jessica, Afanasyeva, Ksenia, Kornblit, Brian, Jurado, Manuel, Martínez, Carmen, Natale, Annalisa, Pérez-Simón, José A., Brunello, Lucia, Avenoso, Daniele, Klein, Stefan, Ozkurt, Zubeyde Nur, Herrera, Concha, Wichert, Stina, Chiusolo, Patrizia, Gavriilaki, Eleni, Basak, Grzegorz W., Schoemans, Hélène, Koenecke, Christian, Moiseev, Ivan, and Peric, Zinaida

Abstract

Introduction: Extracorporal Photophoresis (ECP) is in clinical use for steroid-refractory and steroid-dependent acute GVHD (SR-aGVHD). Based on recent Phase-III study results, ruxolitinib has become the new standard of care for SR-aGVHD. Our aim was to collect comparative data between ruxolitinib and ECP in SR-aGVHD in order to improve the evidence base for clinical decision making., Methods: We asked EBMT centers if they were willing to participate in this study by completing a data form (Med-C) with detailed information on GVHD grading, -therapy, -dosing, -response and complications for each included patient., Results: 31 centers responded positively (14%) and we included all patients receiving alloSCT between 1/2017-7/2019 and treated with ECP or ruxolitinib for SR-aGVHD grades II-IV from these centers. We identified 53 and 40 patients with grades II-IV SR-aGVHD who were treated with ECP and ruxolitinib, respectively. We performed multivariate analyses adjusted on grading and type of SR-aGVHD (steroid dependent vs. refractory). At day+90 after initiation of treatment for SR-aGVHD we found no statistically significant differences in overall response. The odds ratio in the ruxolitinib group to achieve overall response vs. the ECP group was 1.13 (95% CI = [0.41; 3.22], p = 0.81). In line, we detected no statistically significant differences in overall survival, progression-free survival, non-relapse mortality and relapse incidence., Discussion: The clinical significance is limited by the retrospective study design and the current data can’t replace prospective studies on ECP in SR-aGVHD. However, the present results contribute to the accumulating evidence on ECP as an effective treatment option in SR-aGVHD.

Published
2023

41. Tisagenlecleucel CAR-T for relapsed/refractory diffuse large B-cell lymphoma, one therapy; two different clinical presentations. An urgent need to design adverse event predictors

Author

Tomasik, Jaromir, primary, Drozd-Sokołowska, Joanna, additional, Kacprzyk, Piotr, additional, Tomaszewska, Agnieszka, additional, Machowicz, Rafał, additional, Urbanowska, Elżbieta, additional, Witkowska, Samanta, additional, and Basak, Grzegorz Władysław, additional

Published
2023
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42. Severe cytopenia after CD19 CAR T-cell therapy: a retrospective study from the EBMT Transplant Complications Working Party

Author

Penack, Olaf, primary, Peczynski, Christophe, additional, Koenecke, Christian, additional, Polge, Emmanuelle, additional, Kuhnl, Andrea, additional, Fegueux, Nathalie, additional, Daskalakis, Michael, additional, Kröger, Nicolaus, additional, Dreger, Peter, additional, Besley, Caroline, additional, Schanz, Urs, additional, Bloor, Adrian, additional, Ganser, Arnold, additional, Forcade, Edouard, additional, Corral, Lucia López, additional, Passweg, Jakob R, additional, Novak, Urban, additional, Moiseev, Ivan, additional, Schoemans, Hélène, additional, Basak, Grzegorz W, additional, Chabannon, Christian, additional, Sureda, Anna, additional, Averbuch, Dina, additional, Glass, Bertram, additional, de la Camara, Rafael, additional, and Peric, Zinaida, additional

Published
2023
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43. Indications for haematopoietic cell transplantation for haematological diseases, solid tumours and immune disorders: current practice in Europe, 2022

Author

Snowden, John A., Sánchez-Ortega, Isabel, Corbacioglu, Selim, Basak, Grzegorz W., Chabannon, Christian, de la Camara, Rafael, Dolstra, Harry, Duarte, Rafael F., Glass, Bertram, Greco, Raffaella, Lankester, Arjan C., Mohty, Mohamad, Neven, Bénédicte, de Latour, Régis Peffault, Pedrazzoli, Paolo, Perić, Zinaida, Yakoub-Agha, Ibrahim, Sureda, Anna, Kröger, Nicolaus, and UAM. Departamento de Medicina

Subjects
Transplantation, Neoplasms / therapy, Medicina, Haematopoietic cell transplantation (HCT), Cancer development and immune defence Radboud Institute for Molecular Life Sciences [Radboudumc 2], Hematologic Diseases / therapy, Hematopoietic Stem Cell Transplantation, Hematology, Europe, Immune System Diseases / therapy, Immune disorders, HCT, Humans, Haematological diseases, Solid tumours, EBMT
Abstract

For over two decades, the EBMT has updated recommendations on indications for haematopoietic cell transplantation (HCT) practice based on clinical and scientific developments in the field. This is the eighth special EBMT report on the indications for HCT for haematological diseases, solid tumours and immune disorders. Our aim is to provide general guidance on HCT indications according to prevailing clinical practice in EBMT countries and centres. In order to inform patient decisions, these recommendations must be considered in conjunction with the risk of the disease, risk of HCT procedure and non-transplant strategies, including evolving cellular therapies. HCT techniques are constantly evolving and we make no specific recommendations, but encourage harmonisation of practice, where possible, to ensure experience across indications can be meaningfully aggregated via registry outputs. We also recommend working according to JACIE accreditation standards to maintain quality in clinical and laboratory components of practice, including benchmarking of survival outcomes. Since the last edition, the COVID-19 pandemic has affected clinical decision making and activity across indications. Although the full impact of the pandemic is yet to be determined, we recommend that decision making across indications is delivered with ongoing reference to EBMT and national COVID-19 guidance, in accordance with current local conditions.

Published
2022

46. Dysfunctional subsets of CD39+ T cells, distinct from PD-1+, driven by leukemic extracellular vesicles in myeloid leukemias

Author

Swatler, Julian, primary, Lo Tartaro, Domenico, additional, Borella, Rebecca, additional, Brewinska-Olchowik, Marta, additional, Paolini, Annamaria, additional, Neroni, Anita, additional, Turos-Korgul, Laura, additional, Wiech, Milena, additional, Kozlowska, Ewa, additional, Cysewski, Dominik, additional, Grabowska-Pyrzewicz, Wioleta, additional, Wojda, Urszula, additional, Basak, Grzegorz, additional, Argüello, Rafael J., additional, Cossarizza, Andrea, additional, De Biasi, Sara, additional, and Piwocka, Katarzyna, additional

Published
2022
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47. Artificial Intelligence Methods to Estimate Overall Mortality and Non-Relapse Mortality Following Allogeneic Hematopoietic Cell Transplantation in the Modern Era: An EBMT Transplant Complications Working Party Study

Author

Rius Sansalvador, Blanca, primary, Mussetti, Alberto, additional, Moreno, Victor, additional, Peczynski, Christophe, additional, Polge, Emmanuelle, additional, Kröger, Nicolaus, additional, Blaise, Didier, additional, Peffault de Latour, Régis, additional, Kulagin, Alexander D., additional, Mousavi, Ashrafsadat, additional, Stelljes, Matthias, additional, Hamladji, Rose-Marie, additional, Bornhäuser, Martin, additional, Salmenniemi, Urpu, additional, Sengeloev, Henrik, additional, Forcade, Edouard, additional, Platzbecker, Uwe, additional, Reményi, Péter, additional, Angelucci, Emanuele, additional, Chevallier, Patrice, additional, Yakoub-Agha, Ibrahim, additional, Craddock, Charles, additional, Ciceri, Fabio, additional, Schroeder, Thomas, additional, Aljurf, Mahmoud, additional, Moiseev, Ivan, additional, Penack, Olaf, additional, Schoemans, Helene, additional, Mohty, Mohamad, additional, Glass, Bertram, additional, Sureda, Anna, additional, Basak, Grzegorz W, additional, and Peric, Zinaida, additional

Published
2022
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48. Hypoxia Regulates the Immunoregulatory Properties of CD71+ Erythroid Cells

Author

Grzywa, Tomasz M., primary, Justyniarska, Magdalena, additional, Sosnowska, Anna, additional, Szpak, Patrycja, additional, Czubak, Karol, additional, Fidyt, Klaudyna, additional, Kalaszczynska, Ilona, additional, Małecka-Giełdowska, Milena, additional, Ciepiela, Olga, additional, Tomaszewska, Agnieszka, additional, Basak, Grzegorz W, additional, Golab, Jakub, additional, and Nowis, Dominika, additional

Published
2022
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49. Organ Complications after CD19 CAR T-Cell Therapy for Large B Cell Lymphoma. a Retrospective Study from the EBMT Transplant Complications and Lymphoma Working Partys

Author

Penack, Olaf, primary, Peczynski, Christophe, additional, Koenecke, Christian, additional, Polge, Emmanuelle, additional, Potter, Victoria, additional, Yakoub-Agha, Ibrahim, additional, Fegueux, Nathalie, additional, Daskalakis, Michael, additional, Collin, Matthew P., additional, Dreger, Peter, additional, Kröger, Nicolaus, additional, Schanz, Urs, additional, Bloor, Adrian, additional, Ganser, Arnold, additional, Besley, Caroline, additional, Wulf, Gerald, additional, Novak, Urban, additional, Moiseev, Ivan, additional, Schoemans, Helene, additional, Basak, Grzegorz W, additional, Chabannon, Christian, additional, Sureda, Anna, additional, Glass, Bertram, additional, and Peric, Zinaida, additional

Published
2022
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50. Severe Cytopenia after CD19 CAR T-Cell Therapy: A Retrospective Study from the EBMT Transplant Complications Working Party

Author

Penack, Olaf, primary, Peczynski, Christophe, additional, Koenecke, Christian, additional, Polge, Emmanuelle, additional, Potter, Victoria, additional, Fegueux, Nathalie, additional, Daskalakis, Michael, additional, Kröger, Nicolaus, additional, Dreger, Peter, additional, Besley, Caroline, additional, Schanz, Urs, additional, Bloor, Adrian, additional, Ganser, Arnold, additional, Forcade, Edouard, additional, Corral, Lucía López, additional, Passweg, Jakob, additional, Novak, Urban, additional, Moiseev, Ivan, additional, Schoemans, Helene, additional, Basak, Grzegorz W., additional, Chabannon, Christian, additional, Sureda, Anna, additional, Averbuch, Diana, additional, Glass, Bertram, additional, De La Camara, Rafael, additional, and Peric, Zinaida, additional

Published
2022
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