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2. Ginkgo biloba: A Leaf of Hope in the Fight against Alzheimer’s Dementia: Clinical Trial Systematic Review

Author

Pagotto, Guilherme Lopes de Oliveira, primary, Santos, Livia Maria Oliveira dos, additional, Osman, Najwa, additional, Lamas, Caroline Barbalho, additional, Laurindo, Lucas Fornari, additional, Pomini, Karina Torres, additional, Guissoni, Leila M., additional, Lima, Enzo Pereira de, additional, Goulart, Ricardo de Alvares, additional, Catharin, Virginia M. C. Strozze, additional, Direito, Rosa, additional, Tanaka, Masaru, additional, and Barbalho, Sandra Maria, additional

Published
2024
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3. Curcumin: A Golden Approach to Healthy Aging: A Systematic Review of the Evidence.

Author

Nunes, Yandra Cervelim, Mendes, Nathalia M., Pereira de Lima, Enzo, Chehadi, Amanda Chabrour, Lamas, Caroline Barbalho, Haber, Jesselina F. S., dos Santos Bueno, Manoela, Araújo, Adriano Cressoni, Catharin, Vitor C. Strozze, Detregiachi, Claudia Rucco P., Laurindo, Lucas Fornari, Tanaka, Masaru, Barbalho, Sandra Maria, and Marin, Maria José Sanches

Abstract

Aging-related disorders pose significant challenges due to their complex interplay of physiological and metabolic factors, including inflammation, oxidative stress, and mitochondrial dysfunction. Curcumin, a natural compound with potent antioxidant and anti-inflammatory properties, has emerged as a promising candidate for mitigating these age-related processes. However, gaps in understanding the precise mechanisms of curcumin's effects and the optimal dosages for different conditions necessitate further investigation. This systematic review synthesizes current evidence on curcumin's potential in addressing age-related disorders, emphasizing its impact on cognitive function, neurodegeneration, and muscle health in older adults. By evaluating the safety, efficacy, and mechanisms of action of curcumin supplementation, this review aims to provide insights into its therapeutic potential for promoting healthy aging. A systematic search across three databases using specific keywords yielded 2256 documents, leading to the selection of 15 clinical trials for synthesis. Here, we highlight the promising potential of curcumin as a multifaceted therapeutic agent in combating age-related disorders. The findings of this review suggest that curcumin could offer a natural and effective approach to enhancing the quality of life of aging individuals. Further research and well-designed clinical trials are essential to validate these findings and optimize the use of curcumin in personalized medicine approaches for age-related conditions. [ABSTRACT FROM AUTHOR]

Published
2024
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4. Underlying Mechanisms behind the Brain–Gut–Liver Axis and Metabolic-Associated Fatty Liver Disease (MAFLD): An Update

Author

De Cól, Júlia Pauli, primary, de Lima, Enzo Pereira, additional, Pompeu, Fernanda Moris, additional, Cressoni Araújo, Adriano, additional, de Alvares Goulart, Ricardo, additional, Bechara, Marcelo Dib, additional, Laurindo, Lucas Fornari, additional, Méndez-Sánchez, Nahum, additional, and Barbalho, Sandra Maria, additional

Published
2024
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5. Glycolipid Metabolic Disorders, Metainflammation, Oxidative Stress, and Cardiovascular Diseases: Unraveling Pathways.

Author

de Lima, Enzo Pereira, Moretti Jr., Renato Cesar, Torres Pomini, Karina, Laurindo, Lucas Fornari, Sloan, Kátia Portero, Sloan, Lance Alan, Castro, Marcela Vialogo Marques de, Baldi Jr., Edgar, Ferraz, Bruna Fidencio Rahal, de Souza Bastos Mazuqueli Pereira, Eliana, Catharin, Virgínia Maria Cavallari Strozze, Mellen, Carolina Haber, Caracio, Flávia Cristina Castilho, Spilla, Caio Sérgio Galina, Haber, Jesselina F. S., and Barbalho, Sandra Maria

Subjects
ADVANCED glycation end-products, METABOLIC disorders, CARDIOVASCULAR diseases, HORMONE regulation, INSULIN resistance, ATP-binding cassette transporters, ISLANDS of Langerhans
Abstract

Simple Summary: Glycolipid metabolic disorders (GLMDs) result from imbalances in glycolipid levels, leading to various health issues, including obesity, diabetes, liver problems, nerve and muscle complications, and cardiovascular and kidney diseases. This study explores the connection between GLMDs, oxidative stress, and chronic inflammation, which exacerbate these conditions. GLMD originates from disruptions in glucose and fat metabolism, often associated with hormone regulation and insulin resistance. These disruptions cause the accumulation of harmful molecules, triggering inflammation in multiple organs. Key molecules, such as advanced glycation end products (AGEs) and sphingosine-1-phosphate (S1P), play significant roles in this process. Understanding these relationships is essential for developing better treatments, reducing illness and mortality rates, lowering healthcare costs, and improving quality of life. Glycolipid metabolic disorders (GLMDs) are various metabolic disorders resulting from dysregulation in glycolipid levels, consequently leading to an increased risk of obesity, diabetes, liver dysfunction, neuromuscular complications, and cardiorenal vascular diseases (CRVDs). In patients with GLMDs, excess caloric intake and a lack of physical activity may contribute to oxidative stress (OxS) and systemic inflammation. This study aimed to review the connection between GLMD, OxS, metainflammation, and the onset of CRVD. GLMD is due to various metabolic disorders causing dysfunction in the synthesis, breakdown, and absorption of glucose and lipids in the body, resulting in excessive ectopic accumulation of these molecules. This is mainly due to neuroendocrine dysregulation, insulin resistance, OxS, and metainflammation. In GLMD, many inflammatory markers and defense cells play a vital role in related tissues and organs, such as blood vessels, pancreatic islets, the liver, muscle, the kidneys, and adipocytes, promoting inflammatory lesions that affect various interconnected organs through their signaling pathways. Advanced glycation end products, ATP-binding cassette transporter 1, Glucagon-like peptide-1, Toll-like receptor-4, and sphingosine-1-phosphate (S1P) play a crucial role in GLMD since they are related to glucolipid metabolism. The consequences of this is system organ damage and increased morbidity and mortality. [ABSTRACT FROM AUTHOR]

Published
2024
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6. Plant-Derived Bioactive Compounds: Exploring Neuroprotective, Metabolic, and Hepatoprotective Effects for Health Promotion and Disease Prevention.

Author

Direito, Rosa, Barbalho, Sandra Maria, Sepodes, Bruno, and Figueira, Maria Eduardo

Subjects
*SCIENTIFIC knowledge, *BIOACTIVE compounds, *HEALTH promotion, *PREVENTIVE medicine, *CLIMATE change, *GRAPES, *ARTICHOKES
Abstract

There is a growing trend among consumers to seek out natural foods and products with natural ingredients. This shift in consumer preferences had a direct impact on both food and pharmaceutical industries, leading to a focus of scientific research and commercial efforts to meet these new demands. The aim of this work is to review recent available scientific data on foods of interest, such as the artichoke, gooseberry, and polygonoideae plants, as well as olive oil and red raspberries. Interestingly, the urgency of solutions to the climate change emergency has brought new attention to by-products of grapevine bunch stem and cane, which have been found to contain bioactive compounds with potential health benefits. There is a pressing need for a faster process of translating scientific knowledge from the laboratory to real-world applications, especially in the face of the increasing societal burden associated with non-communicable diseases (NCDs), environmental crises, the post-pandemic world, and ongoing violent conflicts around the world. [ABSTRACT FROM AUTHOR]

Published
2024
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7. Effects of Smallanthus sonchifolius Flour on Metabolic Parameters: A Systematic Review.

Author

Silva, Isabela Frazão da, Bragante, Wesley Rossi, Junior, Renato Cesar Moretti, Laurindo, Lucas Fornari, Guiguer, Elen Landgraf, Araújo, Adriano Cressoni, Fiorini, Adriana M. R., Nicolau, Claudia C. T., Oshiiwa, Marie, Lima, Enzo Pereira de, Barbalho, Sandra Maria, and Silva, Luís R.

Subjects
YACON, ADIPOSE tissues, INULIN, FAT, FLOUR, BLOOD lipids, OXIDANT status
Abstract

Smallanthus sonchifolius, popularly known as yacon, is a member of the Asteraceae family. Due to its medicinal and edible value, yacon is consumed by different populations. Yacon is unique due to its high fructo-oligosaccharide and inulin content, as well as flavonoids, sesquiterpene lactones, and phenolic acids. Roots can be used to produce flour, which is less perishable and can be applied in various industrial products. This systematic review focuses on the effects of yacon flour on metabolic parameters. PubMed, Cochrane, Embase, Science Direct, Scopus, Web of Science, and Google Scholar databases were consulted, and PRISMA guidelines were followed in the selection of the studies. In total, 526 articles were found in the databases, and of these, only 28 full texts were eligible for inclusion. After applying the inclusion and exclusion criteria, seven studies were finally included. The results showed that the use of yacon flour can reduce glycemia, HbA1c, advanced glycation ends, plasma lipids, body fat mass, body weight, and waist circumference and improve intestinal microbiota and the antioxidant status. Further exploration of the effects of yacon flour is warranted, and additional clinical trials are necessary to determine the optimal daily consumption levels required to assist in improving metabolic parameters. [ABSTRACT FROM AUTHOR]

Published
2024
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8. New Trends to Treat Muscular Atrophy: A Systematic Review of Epicatechin

Author

German, Iris Jasmin Santos, primary, Pomini, Karina Torres, additional, Andreo, Jesus Carlos, additional, Shindo, João Vitor Tadashi Cosin, additional, Castro, Marcela Vialogo Marques de, additional, Detregiachi, Claudia Rucco P., additional, Araújo, Adriano Cressoni, additional, Guiguer, Elen Landgraf, additional, Fornari Laurindo, Lucas, additional, Bueno, Patrícia Cincotto dos Santos, additional, Souza, Maricelma da Silva Soares de, additional, Gabaldi, Marcia, additional, Barbalho, Sandra Maria, additional, and Shinohara, André Luis, additional

Published
2024
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9. Mangifera indica L., By-Products, and Mangiferin on Cardio-Metabolic and Other Health Conditions: A Systematic Review

Author

Minniti, Giulia, primary, Laurindo, Lucas Fornari, additional, Machado, Nathalia Mendes, additional, Duarte, Lidiane Gonsalves, additional, Guiguer, Elen Landgraf, additional, Araujo, Adriano Cressoni, additional, Dias, Jefferson Aparecido, additional, Lamas, Caroline Barbalho, additional, Nunes, Yandra Crevelin, additional, Bechara, Marcelo Dib, additional, Baldi Júnior, Edgar, additional, Gimenes, Fabrício Bertoli, additional, and Barbalho, Sandra Maria, additional

Published
2023
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10. Investigating the Neuroprotective and Cognitive-Enhancing Effects of Bacopa monnieri : A Systematic Review Focused on Inflammation, Oxidative Stress, Mitochondrial Dysfunction, and Apoptosis.

Author

Valotto Neto, Luiz José, Reverete de Araujo, Matheus, Moretti Junior, Renato Cesar, Mendes Machado, Nathalia, Joshi, Rakesh Kumar, dos Santos Buglio, Daiane, Barbalho Lamas, Caroline, Direito, Rosa, Fornari Laurindo, Lucas, Tanaka, Masaru, and Barbalho, Sandra Maria

Subjects
BACOPA monnieri, OXIDATIVE stress, NEURAL transmission, BETULINIC acid, CONTINUOUS performance test, INFLAMMATION, MITOCHONDRIA, APOPTOSIS
Abstract

The aging of the global population has increased the prevalence of neurodegenerative conditions. Bacopa monnieri (BM), an herb with active compounds, such as bacosides A and B, betulinic acid, loliolide, asiatic acid, and quercetin, demonstrates the potential for brain health. Limited research has been conducted on the therapeutic applications of BM in neurodegenerative conditions. This systematic review aims to project BM's beneficial role in brain disorders. BM has anti-apoptotic and antioxidant actions and can repair damaged neurons, stimulate kinase activity, restore synaptic function, improve nerve transmission, and increase neuroprotection. The included twenty-two clinical trials demonstrated that BM can reduce Nuclear Factor-κB phosphorylation, improve emotional function, cognitive functions, anhedonia, hyperactivity, sleep routine, depression, attention deficit, learning problems, memory retention, impulsivity, and psychiatric problems. Moreover, BM can reduce the levels of pro-inflammatory biomarkers and oxidative stress. Here, we highlight that BM provides notable therapeutic benefits and can serve as a complementary approach for the care of patients with neurodegenerative conditions associated with brain disorders. This review adds to the growing interest in natural products and their potential therapeutic applications by improving our understanding of the mechanisms underlying cognitive function and neurodegeneration and informing the development of new therapeutic strategies for neurodegenerative diseases. [ABSTRACT FROM AUTHOR]

Published
2024
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11. Investigating the Incidence of Dyslipidemia among Brazilian Children and Adolescents Diagnosed with Type 1 Diabetes Mellitus: A Cross-Sectional Study.

Author

Fagundes Melo, Rafael, Laurindo, Lucas Fornari, Sloan, Katia Portero, Sloan, Lance Alan, Cressoni Araújo, Adriano, Bitelli, Piero, Laís Menegucci Zutin, Tereza, Haber Mellen, Rodrigo, Junqueira Mellen, Luciano, Landgraf Guiguer, Elen, Cera Albarossi, João Paulo, Rocha Gabaldi, Márcia, Cincotto dos S. Bueno, Patricia, Francisco dos Santos Haber, Jesselina, Barbalho, Sandra Maria, and Federighi Baisi Chagas, Eduardo

Subjects
TYPE 1 diabetes, INSULIN, DYSLIPIDEMIA, PHYSICAL activity, FAT, CROSS-sectional method, TEENAGE girls
Abstract

The treatment of Type 1 Diabetes Mellitus (T1DM) has always been a challenge for health professionals in relation to glycemic control. Increased body fat has been related to a worsening of the lipid profile and increased prevalence of dyslipidemia in this population, leading to negative repercussions on the control of cardiovascular risk. We aimed to investigate the distribution of lipid levels and the presence of dyslipidemia in children and adolescents with T1DM. A cross-sectional observational study was conducted with 81 individuals of both sexes (4–19 years) diagnosed with T1DM. Anthropometric and biochemical data were collected, in addition to data on physical activity level, sexual maturation stage, and insulin administration regimen. Lipid levels were categorized as normal, borderline, and elevated, and the presence of dyslipidemia was diagnosed by the presence of one or more altered lipid parameter. We noted a prevalence of dyslipidemia in 65.4% of the participants when considering borderline lipid values. Of those, 23.5% had one altered lipid level, and 42.0% had two or more. The main altered lipid levels were total cholesterol and triglycerides, followed by non-HDL-c. The main factor associated with the worsening of lipid levels was the increase in HbA1c. Sex had a significant effect on the levels of TC, HDL-c, and ApoA-I. The results of this study reinforce the need to monitor lipid profile in children and adolescents with T1DM, as well as the importance of early intervention in treating dyslipidemia, especially in patients with poor glycemic control. [ABSTRACT FROM AUTHOR]

Published
2024
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12. Radiological and Functional Pulmonary Evolution in Post-COVID-19 Patients: An Observational Study

Author

Cavallari Strozze Catharin, Virgínia Maria, primary, Zutin, Tereza Laís Menegucci, additional, Guiguer, Elen Landgraf, additional, Cressoni Araújo, Adriano, additional, Fornari Laurindo, Lucas, additional, Chagas, Eduardo F. Baisi, additional, Gasparotti Zorzetto, Cássia Fernanda, additional, Bueno, Patrícia C. dos Santos, additional, dos Santos Bueno, Manoela, additional, Cervelim Nunes, Yandra, additional, Cavallari Strozze Catharin, Vitor, additional, Gonzaga, Heron Fernando, additional, and Barbalho, Sandra Maria, additional

Published
2023
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14. Medicinal Plants, Phytochemicals and Regulation of the NLRP3 Inflammasome in Inflammatory Bowel Diseases: A Comprehensive Review

Author

Direito, Rosa, primary, Barbalho, Sandra Maria, additional, Figueira, Maria Eduardo, additional, Minniti, Giulia, additional, de Carvalho, Gabriel Magno, additional, de Oliveira Zanuso, Bárbara, additional, de Oliveira dos Santos, Ana Rita, additional, de Góes Corrêa, Natália, additional, Rodrigues, Victória Dogani, additional, de Alvares Goulart, Ricardo, additional, Guiguer, Elen Landgraf, additional, Araújo, Adriano Cressoni, additional, Bosso, Henrique, additional, and Fornari Laurindo, Lucas, additional

Published
2023
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15. Organokines in COVID-19: A Systematic Review

Author

Barbalho, Sandra Maria, primary, Minniti, Giulia, additional, Miola, Vitor Fernando Bordin, additional, Haber, Jesselina Francisco dos Santos, additional, Bueno, Patrícia Cincotto dos Santos, additional, de Argollo Haber, Luiza Santos, additional, Girio, Raul S. J., additional, Detregiachi, Cláudia Rucco Penteado, additional, Dall’Antonia, Camila Tiveron, additional, Rodrigues, Victória Dogani, additional, Nicolau, Claudia C. T., additional, Catharin, Virginia Maria Cavallari Strozze, additional, Araújo, Adriano Cressoni, additional, and Laurindo, Lucas Fornari, additional

Published
2023
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18. Effects of Medicinal Plants and Phytochemicals in Nrf2 Pathways during Inflammatory Bowel Diseases and Related Colorectal Cancer: A Comprehensive Review

Author

Laurindo, Lucas Fornari, primary, de Maio, Mariana Canevari, additional, Minniti, Giulia, additional, de Góes Corrêa, Natália, additional, Barbalho, Sandra Maria, additional, Quesada, Karina, additional, Guiguer, Elen Landgraf, additional, Sloan, Kátia Portero, additional, Detregiachi, Claudia R. P., additional, Araújo, Adriano Cressoni, additional, and de Alvares Goulart, Ricardo, additional

Published
2023
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22. Phytochemicals and Regulation of NF-kB in Inflammatory Bowel Diseases: An Overview of In Vitro and In Vivo Effects

Author

Laurindo, Lucas Fornari, primary, Santos, Ana Rita de Oliveira dos, additional, Carvalho, Antonelly Cassio Alves de, additional, Bechara, Marcelo Dib, additional, Guiguer, Elen Landgraf, additional, Goulart, Ricardo de Alvares, additional, Vargas Sinatora, Renata, additional, Araújo, Adriano Cressoni, additional, and Barbalho, Sandra Maria, additional

Published
2023
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23. Insights into Pathogenesis, Nutritional and Drug Approach in Sarcopenia: A Systematic Review

Author

Mellen, Rodrigo Haber, primary, Girotto, Otávio Simões, additional, Marques, Eduarda Boni, additional, Laurindo, Lucas Fornari, additional, Grippa, Paulo Cesar, additional, Mendes, Claudemir Gregório, additional, Garcia, Lorena Natalino Haber, additional, Bechara, Marcelo Dib, additional, Barbalho, Sandra Maria, additional, Sinatora, Renata Vargas, additional, Haber, Jesselina Francisco dos Santos, additional, Flato, Uri Adrian P., additional, Bueno, Patricia Cincotto dos Santos, additional, Detregiachi, Claudia Rucco Penteado, additional, and Quesada, Karina, additional

Published
2023
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24. Melatonin receptors and Per1 expression in the inferior olivary nucleus of the Sapajus apella monkey

Author

Granado, Marcos Donizete Junior, primary, Pinato, Luciana, additional, Santiago, Jeferson, additional, Barbalho, Sandra Maria, additional, Parmezzan, Jessica Ellen Lima, additional, Suzuki, Lenita Mayumi, additional, Cabrini, Mayara Longui, additional, Spressão, Daniele Raineri Mesquita Serva, additional, Carneiro de Camargo, Ana Letícia, additional, and Guissoni Campos, Leila Maria, additional

Published
2022
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25. Organokines, Sarcopenia, and Metabolic Repercussions: The Vicious Cycle and the Interplay with Exercise

Author

Minniti, Giulia, primary, Pescinini-Salzedas, Letícia Maria, additional, Minniti, Guilherme Almeida dos Santos, additional, Laurindo, Lucas Fornari, additional, Barbalho, Sandra Maria, additional, Vargas Sinatora, Renata, additional, Sloan, Lance Alan, additional, Haber, Rafael Santos de Argollo, additional, Araújo, Adriano Cressoni, additional, Quesada, Karina, additional, Haber, Jesselina F. dos Santos, additional, Bechara, Marcelo Dib, additional, and Sloan, Katia Portero, additional

Published
2022
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26. Organokines in Rheumatoid Arthritis: A Critical Review

Author

Laurindo, Lucas Fornari, primary, de Maio, Mariana Canevari, additional, Barbalho, Sandra Maria, additional, Guiguer, Elen Landgraf, additional, Araújo, Adriano Cressoni, additional, de Alvares Goulart, Ricardo, additional, Flato, Uri Adrian Prync, additional, Júnior, Edgar Baldi, additional, Detregiachi, Cláudia Rucco Penteado, additional, dos Santos Haber, Jesselina Francisco, additional, Bueno, Patrícia C. Santos, additional, Girio, Raul S. J., additional, Eleutério, Rachel Gomes, additional, and Bechara, Marcelo Dib, additional

Published
2022
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29. Ginkgo biloba in the Aging Process: A Narrative Review

Author

Barbalho, Sandra Maria, primary, Direito, Rosa, additional, Laurindo, Lucas Fornari, additional, Marton, Ledyane Taynara, additional, Guiguer, Elen Landgraf, additional, Goulart, Ricardo de Alvares, additional, Tofano, Ricardo José, additional, Carvalho, Antonely C. A., additional, Flato, Uri Adrian Prync, additional, Capelluppi Tofano, Viviane Alessandra, additional, Detregiachi, Cláudia Rucco Penteado, additional, Bueno, Patrícia C. Santos, additional, Girio, Raul S. J., additional, and Araújo, Adriano Cressoni, additional

Published
2022
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30. Association of Metabolic Syndrome and Hyperferritinemia in Patients at Cardiovascular Risk

Author

Tofano, Ricardo José, Pescinni-Salzedas, Leticia Maria, Chagas, Eduardo Federighi Baisi, Detregiachi, Claudia Rucco Penteado, Guiguer, Elen Landgraf, Araujo, Adriano Cressoni, Bechara, Marcelo Dib, Rubira, Claudio José, and Barbalho, Sandra Maria

Subjects
iron overload syndrome, cardiovascular disease, hyperferritinemia, Targets and Therapy [Diabetes, Metabolic Syndrome and Obesity], metabolic syndrome, Original Research
Abstract

Ricardo José Tofano,1,2 Leticia Maria Pescinni-Salzedas,1 Eduardo Federighi Baisi Chagas,2 Claudia Rucco Penteado Detregiachi,2 Elen Landgraf Guiguer,1– 3 Adriano Cressoni Araujo,1,2 Marcelo Dib Bechara,1 Claudio José Rubira,1 Sandra Maria Barbalho1– 3 1Department of Biochemistry and Pharmacology, School of Medicine, University of Marília (UNIMAR), Marília, São Paulo, Brazil; 2Postgraduate Program in Structural and Functional Interactions in Rehabilitation, UNIMAR, Marília, São Paulo, Brazil; 3School of Food and Technology of Marilia (FATEC), Marilia, São Paulo, BrazilCorrespondence: Sandra Maria BarbalhoDepartment of Biochemistry and Pharmacology, School of Medicine, University of Marília (UNIMAR), Av. Higino Muzzi Filho 1001, Marília 15525-902, São Paulo, BrazilTel +55 14 99655-3190Email smbarbalho@gmail.comAim: To evaluate the association between parameters of hyperferritinemia (HF) and metabolic syndrome (MS) in patients at cardiovascular risk.Patients and Methods: This is a cross-sectional analytical observational study that included 269 patients who attended a cardiology unit. Biochemical and anthropometric parameters were evaluated to identify the presence of HF and MS. The presence of MS was evaluated according to NCEP ATP III. Biochemical parameters (glycemia, triglycerides, HDL-c) were assessed according to the manufacturer’s protocols. Anthropometric measurements and blood pressure measurements were made by a trained professional. The chi-square (X2) test, odds ratio, normality distribution (verified by the Kolmogorov–Smirnov test), and Levene’s test were used to analyze the variables. To evaluate the effect of MS, HF, and the interaction between MS and HF, two-way analysis of variance (ANOVA) was performed based on the homogeneity of the variances, followed by Bonferroni’s post hoc comparisons. Spearman correlation analysis was performed to evaluate the relationship between quantitative variables. A multiple linear regression model was used to analyze the effect of covariables. A logistic regression model was built to analyze the variables that contribute significantly to predict the outcome (HF) using the backward method.Results: Our results showed that 57% of men and 49.5% of women presented with MS; 44% of men and 11% of women presented with HF. The presence of MS and hypertriglyceridemia increase the probability of having HF by up to 2.1 and 1.88 times, respectively, while for male sex it is increased by 6.2 times. Patients with HF have higher values of C-reactive protein, ferritin, and transferrin saturation, regardless of the presence of MS. The linear regression analysis model indicated that the variables considered in this study explain less than 30% of the variation in ferritin and that the presence of MS in men is responsible for 22% of the variation in the probability of the occurrence of HF.Conclusion: Our results show that hyperferritinemia is closely associated with the components of MS (positive correlation with glycemia, triglycerides levels, blood pressure, and waist circumference, and negative correlation with HDL-c values) in the studied population.Keywords: cardiovascular disease, hyperferritinemia, iron overload syndrome, metabolic syndrome

Published
2020

31. Relationship of Inflammatory Markers and Metabolic Syndrome in Postmenopausal Women

Author

Sinatora, Renata Vargas, primary, Chagas, Eduardo Federighi Baisi, additional, Mattera, Fernando Otavio Pires, additional, Mellem, Luciano Junqueira, additional, Santos, Ana Rita de Oliveira dos, additional, Pereira, Larissa Pires, additional, Aranão, Ana Luíza de Carvalho, additional, Guiguer, Elen Landgraf, additional, Araújo, Adriano Cressoni, additional, Haber, Jesselina F. dos Santos, additional, Guissoni, Leila Campos, additional, and Barbalho, Sandra Maria, additional

Published
2022
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32. GLP-1a: Going beyond Traditional Use

Author

Laurindo, Lucas Fornari, primary, Barbalho, Sandra Maria, additional, Guiguer, Elen Landgraf, additional, da Silva Soares de Souza, Maricelma, additional, de Souza, Gabriela Achete, additional, Fidalgo, Thiago Marques, additional, Araújo, Adriano Cressoni, additional, de Souza Gonzaga, Heron F., additional, de Bortoli Teixeira, Daniel, additional, de Oliveira Silva Ullmann, Thais, additional, Sloan, Katia Portero, additional, and Sloan, Lance Alan, additional

Published
2022
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33. Non-Alcoholic Steatohepatitis (NASH) and Organokines: What Is Now and What Will Be in the Future

Author

Santos, João Paulo Margiotti dos, primary, Maio, Mariana Canevari de, additional, Lemes, Monike Alves, additional, Laurindo, Lucas Fornari, additional, Haber, Jesselina Francisco dos Santos, additional, Bechara, Marcelo Dib, additional, Prado, Pedro Sidnei do, additional, Rauen, Eduardo Costa, additional, Costa, Fernando, additional, Pereira, Barbara Cristina de Abreu, additional, Flato, Uri Adrian Prync, additional, Goulart, Ricardo de Alvares, additional, Chagas, Eduardo Federighi Baisi, additional, and Barbalho, Sandra Maria, additional

Published
2022
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34. Photobiomodulation Therapy as a Possible New Approach in COVID-19: A Systematic Review

Author

de Matos, Brenda Thaynne Lima, primary, Buchaim, Daniela Vieira, additional, Pomini, Karina Torres, additional, Barbalho, Sandra Maria, additional, Guiguer, Elen Landgraf, additional, Reis, Carlos Henrique Bertoni, additional, Bueno, Cleuber Rodrigo de Souza, additional, Cunha, Marcelo Rodrigues da, additional, Pereira, Eliana de Souza Bastos Mazuqueli, additional, and Buchaim, Rogerio Leone, additional

Published
2021
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35. Adipokines, Myokines, and Hepatokines: Crosstalk and Metabolic Repercussions

Author

de Oliveira dos Santos, Ana Rita, primary, de Oliveira Zanuso, Bárbara, additional, Miola, Vitor Fernando Bordin, additional, Barbalho, Sandra Maria, additional, Santos Bueno, Patrícia C., additional, Flato, Uri Adrian Prync, additional, Detregiachi, Claudia Rucco P., additional, Buchaim, Daniela Vieira, additional, Buchaim, Rogério Leone, additional, Tofano, Ricardo José, additional, Mendes, Claudemir Gregório, additional, Tofano, Viviane Alessandra Capelluppi, additional, and dos Santos Haber, Jesselina F., additional

Published
2021
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36. Effects of Consumption of Coconut and Cow's Milk on the Metabolic Profile of Wistar Rats Fed a Hyperprotein Diet

Author

Hauy, Beatriz Nomada, primary, Oliani, Caio Henrique Peres, additional, Fracaro, Gabriela Garcia, additional, Barbalho, Sandra Maria, additional, Guiguer, Élen Landgraf, additional, Souza, Maricelma da Silva Soares de, additional, Mendes, Claudemir Gregório, additional, Bueno, Manoela dos Santos, additional, Araújo, Adriano Cressoni, additional, and Bueno, Patrícia Cincotto dos Santos, additional

Published
2021
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37. Association of Metabolic Syndrome and Hyperferritinemia in Patients at Cardiovascular Risk

Author

Tofano,Ricardo José, Pescinni-Salzedas,Leticia Maria, Chagas,Eduardo Federighi Baisi, Detregiachi,Claudia Rucco Penteado, Guiguer,Elen Landgraf, Araujo,Adriano Cressoni, Bechara,Marcelo Dib, Rubira,Claudio José, Barbalho,Sandra Maria, Tofano,Ricardo José, Pescinni-Salzedas,Leticia Maria, Chagas,Eduardo Federighi Baisi, Detregiachi,Claudia Rucco Penteado, Guiguer,Elen Landgraf, Araujo,Adriano Cressoni, Bechara,Marcelo Dib, Rubira,Claudio José, and Barbalho,Sandra Maria

Abstract

Ricardo José Tofano,1,2 Leticia Maria Pescinni-Salzedas,1 Eduardo Federighi Baisi Chagas,2 Claudia Rucco Penteado Detregiachi,2 Elen Landgraf Guiguer,1– 3 Adriano Cressoni Araujo,1,2 Marcelo Dib Bechara,1 Claudio José Rubira,1 Sandra Maria Barbalho1– 3 1Department of Biochemistry and Pharmacology, School of Medicine, University of Marília (UNIMAR), Marília, São Paulo, Brazil; 2Postgraduate Program in Structural and Functional Interactions in Rehabilitation, UNIMAR, Marília, São Paulo, Brazil; 3School of Food and Technology of Marilia (FATEC), Marilia, São Paulo, BrazilCorrespondence: Sandra Maria BarbalhoDepartment of Biochemistry and Pharmacology, School of Medicine, University of Marília (UNIMAR), Av. Higino Muzzi Filho 1001, Marília 15525-902, São Paulo, BrazilTel +55 14 99655-3190Email smbarbalho@gmail.comAim: To evaluate the association between parameters of hyperferritinemia (HF) and metabolic syndrome (MS) in patients at cardiovascular risk.Patients and Methods: This is a cross-sectional analytical observational study that included 269 patients who attended a cardiology unit. Biochemical and anthropometric parameters were evaluated to identify the presence of HF and MS. The presence of MS was evaluated according to NCEP ATP III. Biochemical parameters (glycemia, triglycerides, HDL-c) were assessed according to the manufacturer’s protocols. Anthropometric measurements and blood pressure measurements were made by a trained professional. The chi-square (X2) test, odds ratio, normality distribution (verified by the Kolmogorov–Smirnov test), and Levene’s test were used to analyze the variables. To evaluate the effect of MS, HF, and the interaction between MS and HF, two-way analysis of variance (ANOVA) was performed based on the homogeneity of the variances, followed by Bonferroni’s pos

Published
2020

38. What Do Influenza and COVID-19 Represent for Patients With Inflammatory Bowel Disease?

Author

Barbalho, Sandra Maria, primary, Matias, Julia Novaes, additional, Flato, Uri Adrian Prync, additional, Pilon, Joao Paulo Galletti, additional, Bitelli, Piero, additional, Junior, Marcos Alberto Pagani, additional, Carvalho, Antonelly Cassio Alves de, additional, Haber, Jesselina Francisco dos Santos, additional, Reis, Carlos Henrique Bertoni, additional, and Goulart, Ricardo de Alvares, additional

Published
2021
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40. Physical Exercise and Myokines: Relationships with Sarcopenia and Cardiovascular Complications

Author

Barbalho, Sandra Maria, primary, Flato, Uri Adrian Prync, additional, Tofano, Ricardo José, additional, Goulart, Ricardo de Alvares, additional, Guiguer, Elen Landgraf, additional, Detregiachi, Cláudia Rucco P., additional, Buchaim, Daniela Vieira, additional, Araújo, Adriano Cressoni, additional, Buchaim, Rogério Leone, additional, Reina, Fábio Tadeu Rodrigues, additional, Biteli, Piero, additional, Reina, Daniela O. B. Rodrigues, additional, and Bechara, Marcelo Dib, additional

Published
2020
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41. Photobiomodulation Therapy Associated with Heterologous Fibrin Biopolymer and Bovine Bone Matrix Helps to Reconstruct Long Bones

Author

Rosso, Marcelie Priscila de Oliveira, primary, Oyadomari, Aline Tiemi, additional, Pomini, Karina Torres, additional, Della Coletta, Bruna Botteon, additional, Shindo, João Vitor Tadashi Cosin, additional, Ferreira Júnior, Rui Seabra, additional, Barraviera, Benedito, additional, Cassaro, Claudia Vilalva, additional, Buchaim, Daniela Vieira, additional, Teixeira, Daniel de Bortoli, additional, Barbalho, Sandra Maria, additional, Alcalde, Murilo Priori, additional, Duarte, Marco Antonio Hungaro, additional, Andreo, Jesus Carlos, additional, and Buchaim, Rogério Leone, additional

Published
2020
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42. Effects of Green Wheat (Triticum turgidum) and Common Wheat (Triticum aestivum) on the Metabolic Profile of Wistar Rats

Author

Bueno, Patrícia Cincotto dos Santos, primary, Barbalho, Sandra Maria, additional, Guiguer, Élen Landgraf, additional, Souza, Maricelma da Silva Soares de, additional, Medeiros, Isabela Ramos Araújo de, additional, Zattiti, Isabella Vasconcelos, additional, Bueno, Manuela dos Santos, additional, Nutels, Giovanna Soares, additional, Goulart, Ricardo de Alvares, additional, and Araújo, Adriano Cressoni, additional

Published
2019
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43. Associação de níveis de HDL-c e não HDL-c com parâmetros antropométricos e bioquímicos

Author

Barbalho, Sandra Maria, Tofano, Ricardo José, Oliveira, Marcela Bueno de, Quesada, Karina Rodrigues, Barion, Mariana Ricci, Akuri, Marina Cristina, Oshiiwa, Marie, and Bechara, Marcelo Dib

Subjects
glycemia, glicemia, non-HDL-c, dyslipidemia, nutritional and metabolic diseases, lipids (amino acids, peptides, and proteins), não HDL-c, dislipidemia, metabolic syndrome, síndrome metabólica
Abstract

Background Dyslipidemias are associated with atherosclerosis and cardiovascular diseases. Recently, non-high-density lipoprotein cholesterol (non-HDL-c) has emerged as a new target for assessment and prediction of risk of cardiovascular disease (CVD) and is closely associated with atheroma plaque progression. Objectives To evaluate associations between HDL-c and non-HDL-c levels and anthropometric and biochemical parameters and with the Castelli risk indexes I and II. Methods 300 randomly selected people were subdivided into two groups: patients with normal values for non-HDL-c and patients with altered values for non-HDL-c. These parameters were analyzed for associations with glycemia, total cholesterol (TC), triglycerides (TG), low-density lipoprotein (LDL-c), Castelli Index I (CI-I), Castelli Index II (CI-II), waist circumference (WC), body mass index (BMI) and presence of metabolic syndrome (MS). Results Glycemia, TC, TG, LDL-c, CI-I, CI-II, WC and BMI were all significantly different between subjects with normal and altered values of HDL-c and non-HDL-c. TC and WC both exhibited significantly higher values among patients with abnormal non-HDL-c when compared to patients with abnormal HDL-c. A significant difference was observed in occurrence of MS among patients with altered values of HDL-c and non-HDL-c. Conclusions Our results show that both HDL-c and non-HDL-c are associated with insulin resistance, dyslipidemia, atherogenic indices, and obesity. There is therefore a need for randomized clinical intervention trials examining the potential role of non-HDL-c as a possible primary therapeutic target. Resumo Contexto A dislipidemia está associada à aterosclerose e às doenças cardiovasculares. Recentemente, a lipoproteína de não alta-densidade de colesterol (não HDL-c) emergiu como um novo alvo para avaliação da predição de risco de doença cardiovascular, intimamente associada à progressão da placa de ateroma. Objetivos Avaliar as associações de níveis de HDL-c e não HDL-c com parâmetros antropométricos e bioquímicos, bem como com índices de Castelli I e II (CI-I e CI-II). Métodos Trezentas pessoas selecionadas aleatoriamente foram divididas em dois grupos: pacientes com valores normais de não HDL-c e pacientes com valores alterados de não HDL-c. Esses parâmetros foram associados a glicemia, colesterol total (CT), triglicerídeos (TG), lipoproteína de baixa densidade (LDL-c), CI-I, CI-II, circunferência de cintura (CC), índice de massa corporal (IMC) e presença de síndrome metabólica (SM). Resultados Glicemia, CT, TG, LDL-c, CI-I, CI-II, CC e IMC exibiram valores significativamente maiores para o não HDL-c quando comparado ao HDL-c. Uma diferença significativa na ocorrência de SM foi encontrada em pacientes com valores alterados de HDL-c e não HDL-c. Conclusões Nossos resultados mostram que tanto o HDL-c quanto o não HDL-c estão associados a resistência à insulina, dislipidemia, índices de aterogênese e obesidade. Assim, há uma necessidade de futuros ensaios randomizados de intervenção clínica examinando o papel potencial do não HDL-c como possível alvo terapêutico primário.

Published
2019

46. Effects of Green and Ripe Coffee in the Metabolic Profile and Muscle Enzymes in Animals Practicing Physical Exercise

Author

Bosso, Henrique, primary, Soares Arantes, Giovanna Emanuella Piffer, additional, Barbalho, Sandra Maria, additional, Guiguer, Élen Landgraf, additional, de Souza, Maricelma da Silva Soares, additional, Bueno, Patrícia Cincotto dos Santos, additional, Chies, Agnaldo Bruno, additional, Oliveira, Priscilla Bianca de, additional, Mendes, Claudemir Gregório, additional, and Araújo, Adriano Cressoni, additional

Published
2019
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47. Effect of Morinda citrifolia and Annona muricata on Erhlich Tumor Cells in Swiss Albino Mice and In Vitro Fibroblast Cells

Author

Torres, Cleber da Silveira, primary, Santos, Francisnaira da Silva, additional, Guiguer, Elen Landgraf, additional, Araújo, Adriano Cressoni de, additional, Barbalho, Sandra Maria, additional, Bueno, Patrícia Cincotto dos Santos, additional, Souza, Maricelma Silva Soares de, additional, Antonini Alves, Danilo, additional, Lancellott, Marcelo, additional, and Moreira, Haydee Maria, additional

Published
2019
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