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2. Platelet Reactivity in Patients With Acute Coronary Syndromes Awaiting Surgical Revascularization

Author

Nakashima, Carlos A.K., Dallan, Luis A.O., Lisboa, Luiz A.F., Jatene, Fabio B., Hajjar, Ludhmila A., Soeiro, Alexandre M., Furtado, Remo H.M., Dalçoquio, Talia F., Baracioli, Luciano M., Lima, Felipe G., Giraldez, Roberto R.C.V., Silva, Bianca A., Costa, Mateus S.S., Strunz, Celia M.C., Dallan, Luis R.P., Barbosa, Carlos J.D.G., Britto, Flavia A.B., Farkouh, Michael E., Gurbel, Paul A., and Nicolau, Jose C.

Published
2021
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4. Sintomas Cardiopulmonares Pós-COVID-19: Preditores e Características de Imagem de Pacientes após a Alta Hospitalar

Author

Roberto, Kalil-Filho, primary, Saretta, Roberta, additional, Franci, André, additional, Baracioli, Luciano M., additional, Galas, Filomena R. B. G., additional, Gil, Juliana S., additional, Ferino, Amanda, additional, Giacovone, Camilla, additional, Oliveira, Isabella, additional, Souza, Johnatan, additional, Batista, Vanessa, additional, Scalabrini, Augusto, additional, Costa, Livia do Valle, additional, Ruiz, Amanda Danieleto, additional, Ledo, Carla B., additional, Nascimento, Teresa Cristina D. C., additional, and Drager, Luciano F., additional

Published
2023
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5. Effects of exercise on platelet reactivity after myocardial infarction: a randomized clinical trial.

Author

Falcão Dalçóquio, Talia, Alves dos Santos, Mayara, Silva Alves, Leandro, Brito Arantes, Flávia Bittar, Ferreira-Santos, Larissa, Pinto Brandão Rondon, Maria Urbana, Furtado, Remo Holanda M., Ferrari, Aline Gehlen, Rizzo, Paulo Roberto Genestreti, Salsoso, Rocio, Franci, Andre, Moreira Baracioli, Luciano, de Nazare Nunes Alves, Maria Janieire, Eduardo Negrão, Carlos, and Carlos Nicolau, José

Subjects
MYOCARDIAL infarction, CLINICAL trials, BLOOD platelets, EXERCISE tests, CARDIOVASCULAR diseases risk factors, ADENOSINE diphosphate
Abstract

Exercise training (ET) can lower platelet reactivity in patients with cardiovascular risk factors. However, the effects of ET on platelet reactivity in higher-risk patients is unknown. The aim of this study was to evaluate the effects of ET on platelet reactivity in patients with recent myocardial infarction (MI). Ninety patients were randomly assigned 1 month post-MI to the intervention (patients submitted to a supervised ET program) or control group. All patients were on dual antiplatelet therapy (DAPT). Platelet reactivity by VerifyNow-P2Y12 (measured by P2Y12 reaction units - PRUs) test was determined at baseline and at the end of 14 ± 2 weeks of follow-up at rest (primary endpoint), and multiplate electrode aggregometry (MEA) adenosine diphosphate (ADP) and aspirin (ASPI) tests were performed immediately before and after the maximal cardiopulmonary exercise test (CPET) at the same time points (secondary endpoints). Sixty-five patients (mean age 58.9 ± 10 years; 73.8% men; 60% ST elevation MI) completed follow-up (control group, n = 31; intervention group, n = 34). At the end of the follow-up, the mean platelet reactivity was 172.8 ± 68.9 PRUs and 166.9 ± 65.1 PRUs for the control and intervention groups, respectively (p = .72). Platelet reactivity was significantly increased after the CPET compared to rest at the beginning and at the end of the 14-week follow-up (among the intervention groups) by the MEA-ADP and MEA-ASPI tests (p < .01 for all analyses). In post-MI patients on DAPT, 14 weeks of supervised ET did not reduce platelet reactivity. Moreover, platelet reactivity was increased after highintensity exercise (ClinicalTrials.gov: NCT02958657; https://clinicaltrials.gov/ct2/show/NCT02958657). [ABSTRACT FROM AUTHOR]

Published
2023
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6. Long‐term mortality after acute coronary syndromes among patients with normal, mildly reduced, or reduced ejection fraction

Author

Furtado, Remo H.M., primary, Juliasz, Marcela G., additional, Chiu, Felipe Y.J., additional, Bastos, Livia B.C., additional, Dalcoquio, Talia F., additional, Lima, Felipe G., additional, Rosa, Renato, additional, Caporrino, Cesar A., additional, Bertolin, Adriadne, additional, Genestreti, Paulo R.R., additional, Ribeiro, Andre S., additional, Andrade, Maria Carolina, additional, Giraldez, Roberto R.C.V., additional, Baracioli, Luciano M., additional, Zelniker, Thomas A., additional, and Nicolau, Jose C., additional

Published
2022
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7. Effects of DPP4 Inhibitor in Platelet Reactivity and Other Cardiac Risk Markers in Patients with Type 2 Diabetes and Acute Myocardial Infarction

Author

Genestreti, Paulo R. Rizzo, primary, Furtado, Remo H. M., additional, Salsoso, Rocio, additional, Dalçóquio, Talia F., additional, Franci, Andre, additional, Menezes, Fernando R., additional, Caporrino, Cesar, additional, Ferrari, Aline G., additional, Nakashima, Carlos A. K., additional, Scanavini Filho, Marco A., additional, Lima, Felipe G., additional, Giraldez, Roberto R. C. V., additional, Baracioli, Luciano M., additional, and Nicolau, Jose C., additional

Published
2022
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10. Long‐term mortality after acute coronary syndromes among patients with normal, mildly reduced, or reduced ejection fraction.

Author

Furtado, Remo H.M., Juliasz, Marcela G., Chiu, Felipe Y.J., Bastos, Livia B.C., Dalcoquio, Talia F., Lima, Felipe G., Rosa, Renato, Caporrino, Cesar A., Bertolin, Adriadne, Genestreti, Paulo R.R., Ribeiro, Andre S., Andrade, Maria Carolina, Giraldez, Roberto R.C.V., Baracioli, Luciano M., Zelniker, Thomas A., and Nicolau, Jose C.

Subjects
ACUTE coronary syndrome, VENTRICULAR ejection fraction, MORTALITY risk factors, HOSPITAL admission & discharge
Abstract

Aims: Left ventricular ejection fraction (LVEF) ≤ 40% is a well‐established risk factor for mortality after acute coronary syndromes (ACS). However, the long‐term prognostic impact of mildly reduced ejection fraction (EF) (LVEF 41–49%) after ACS remains less clear. Methods and results: This was a retrospective study enrolling patients admitted with ACS included in a single‐centre databank. LVEF was assessed by echocardiography during index hospitalization. Patients were divided in the following categories according to LVEF: normal (LVEF ≥ 50%), mildly reduced (LVEF 41–49%), and reduced (LVEF ≤ 40%). The endpoint of interest was all‐cause death after hospital discharge. A multivariable Cox model was used to adjust for confounders. A total of 3200 patients were included (1952 with normal EF, 375 with mildly reduced EF, and 873 with reduced EF). The estimated cumulative incidence rates of mortality at 10 years for patients with normal, mildly reduced, and reduced EF were 24.8%, 33.5%, and 41.3%, respectively. After adjustments, the presence of reduced EF was associated with higher mortality compared with normal EF [adjusted hazard ratio (HR) 1.64; 95% confidence interval (CI) 1.36–1.96; P < 0.001], as was mildly reduced EF compared with normal EF (adjusted HR 1.33; 95% CI 1.05–1.68; P = 0.019). The presence of reduced EF was not associated with a statistically significantly higher mortality compared with mildly reduced EF (adjusted HR 1.23; 95% CI 0.96–1.57; P = 0.095). Conclusions: In patients with ACS, mildly reduced EF measured in the acute phase was associated with higher long‐term mortality compared with patients with normal EF. These data emphasize the importance of anti‐remodelling therapies for ACS patients who have LVEF in the mildly reduced range. [ABSTRACT FROM AUTHOR]

Published
2023
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11. Atualização da Diretriz de Avaliação Cardiovascular Perioperatória da Sociedade Brasileira de Cardiologia: Foco em Manejo dos Pacientes com Intervenção Coronária Percutânea – 2022

Author

Calderaro, Daniela, primary, Bichuette, Luciana Dornfeld, additional, Maciel, Pamela Camara, additional, Cardozo, Francisco Akira Malta, additional, Ribeiro, Henrique Barbosa, additional, Gualandro, Danielle Menosi, additional, Baracioli, Luciano Moreira, additional, Soeiro, Alexandre de Matos, additional, Serrano, Carlos Vicente, additional, Costa, Ricardo Alves da, additional, and Caramelli, Bruno, additional

Published
2022
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12. Abstract 12524: Very Long-term Mortality After St Elevation Myocardial Infarction (stemi) Complicated By Cardiogenic Shock

Author

Kanhouche, Gabriel, primary, Nicolau, Jose, additional, Falcão Dalçoquio, Talia, additional, Marchi, Mauricio Felippi de Sa, additional, Giraldez, Roberto R, additional, Furtado, Remo, additional, Baracioli, Luciano, additional, Kalil Filho, Roberto, additional, de Brito Junior, Fabio, additional, Abizaid, Alexandre, additional, and Ribeiro, Henrique, additional

Published
2021
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13. Abstract 10724: Long-Term Mortality After Acute Coronary Syndromes Among Patients with Normal, Mid-Range or Low Ejection Fraction

Author

Furtado, Remo, primary, Juliasz, Marcela G, additional, CHIU, FELIPE Y, additional, Bastos, Livia B, additional, Dalcoquio, Talia F, additional, Lima, Felipe G, additional, Rosa, Renato, additional, Caporrino, Cesar A, additional, Bertolin, Adriadne, additional, Soffiatti, Carla, additional, Ribeiro, Andre S, additional, Andrade, Maria C, additional, Giraldez, Roberto, additional, Baracioli, Luciano, additional, and Nicolau, Jose C, additional

Published
2021
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14. Abstract 13782: Platelet Aggregation and Adenosine Levels Among Patients With Stable Chronic Coronary Artery Disease Taking Ticagrelor or Prasugrel

Author

Menezes, Fernando, primary, Furtado, Remo, additional, Dalçóquio, Talia, additional, Genestreti, Paulo, additional, Bertolin, Adriadne, additional, Baracioli, Luciano, additional, Scanavini, Marco, additional, oliveira, beatriz, additional, Franci, Andre, additional, Silva, Marli, additional, Roggerio, Alessandra, additional, Ferrari, Aline G, additional, Lima, Viviane, additional, Pereira, Cesar, additional, Nakashima, Carlos A, additional, Strunz, Celia, additional, Salsoso, Rocio, additional, Soffiatti, Carla, additional, Baldo, Vanessa, additional, and Nicolau, Jose C, additional

Published
2021
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15. Effects of exercise on platelet reactivity after myocardial infarction: a randomized clinical trial.

Author

Dalçóquio, Talia Falcão, Alves dos Santos, Mayara, Silva Alves, Leandro, Bittar Brito Arantes, Flávia, Ferreira-Santos, Larissa, Pinto Brandão Rondon, Maria Urbana, Furtado, Remo Holanda M, Gehlen Ferrari, Aline, Genestreti Rizzo, Paulo Roberto, Salsoso, Rocio, Franci, Andre, Moreira Baracioli, Luciano, de Nazare Nunes Alves, Maria Janieire, Negrão, Carlos Eduardo, and Nicolau, José Carlos

Subjects
MYOCARDIAL infarction, CLINICAL trials, BLOOD platelets, CARDIOVASCULAR diseases risk factors, EXERCISE tests, PLATELET aggregation inhibitors
Abstract

Exercise training (ET) can lower platelet reactivity in patients with cardiovascular risk factors. However, the effects of ET on platelet reactivity in higher-risk patients is unknown. The aim of this study was to evaluate the effects of ET on platelet reactivity in patients with recent myocardial infarction (MI). Ninety patients were randomly assigned 1 month post-MI to the intervention (patients submitted to a supervised ET program) or control group. All patients were on dual antiplatelet therapy (DAPT). Platelet reactivity by VerifyNow-P2Y12 (measured by P2Y12 reaction units – PRUs) test was determined at baseline and at the end of 14 ± 2 weeks of follow-up at rest (primary endpoint), and multiplate electrode aggregometry (MEA) adenosine diphosphate (ADP) and aspirin (ASPI) tests were performed immediately before and after the maximal cardiopulmonary exercise test (CPET) at the same time points (secondary endpoints). Sixty-five patients (mean age 58.9 ± 10 years; 73.8% men; 60% ST elevation MI) completed follow-up (control group, n = 31; intervention group, n = 34). At the end of the follow-up, the mean platelet reactivity was 172.8 ± 68.9 PRUs and 166.9 ± 65.1 PRUs for the control and intervention groups, respectively (p =.72). Platelet reactivity was significantly increased after the CPET compared to rest at the beginning and at the end of the 14-week follow-up (among the intervention groups) by the MEA-ADP and MEA-ASPI tests (p <.01 for all analyses). In post-MI patients on DAPT, 14 weeks of supervised ET did not reduce platelet reactivity. Moreover, platelet reactivity was increased after high-intensity exercise (ClinicalTrials.gov: NCT02958657; ). What is the context? Platelet reactivity is reduced after exercise training in healthy individuals and patients with cardiovascular risk factors, but the effect in higher-risk patients is unknown. High-intensity exercise in untrained individuals increases platelet reactivity. The effect of dual antiplatelet therapy in inhibiting exercise-induced hyperreactivity is poorly understood. What's new? Exercise training did not reduce platelet reactivity in post-myocardial infarction patients. High-intensity exercise increased platelet reactivity in post-myocardial infarction patients on dual antiplatelet therapy. Exercise training did not attenuate the exercise-induced increase in platelet reactivity. What's the impact? The study suggests that strenuous exercise, if indicated, should be applied carefully to patients with high risk of recurrent ischemic events, even if on optimal medical therapy and after being trained. [ABSTRACT FROM AUTHOR]

Published
2023
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16. High risk coronavirus disease 2019: The primary results of the CoronaHeart multi-center cohort study

Author

Guimarães, Patrícia O., primary, de Souza, Francis R., additional, Lopes, Renato D., additional, Bittar, Cristina, additional, Cardozo, Francisco A., additional, Caramelli, Bruno, additional, Calderaro, Daniela, additional, Albuquerque, Cícero P., additional, Drager, Luciano F., additional, Feres, Fausto, additional, Baracioli, Luciano, additional, Feitosa Filho, Gilson, additional, Barbosa, Roberto R., additional, Ribeiro, Henrique B., additional, Ribeiro, Expedito, additional, Alves, Renato J., additional, Soeiro, Alexandre, additional, Faillace, Bruno, additional, Figueiredo, Estêvão, additional, Damiani, Lucas P., additional, do Val, Renata M., additional, Huemer, Natassja, additional, Nicolai, Lisiê G., additional, Hajjar, Ludhmila A., additional, Abizaid, Alexandre, additional, and Kalil Filho, Roberto, additional

Published
2021
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17. Primary coronary angioplasty in a nonagenarian

Author

Baracioli Luciano M., Serrano Jr Carlos V., Esteves Antônio, Ciporkin Jean Pierre, and Nicolau José Carlos

Subjects
Diseases of the circulatory (Cardiovascular) system, RC666-701
Abstract

A woman aged 98 years entered the tertiary hospital service with a picture of acute myocardial infarction of the extensive anterior wall, which began 4 hours earlier. Due to the large myocardial risk area suggested by the electrocardiogram, the patient was taken to the hemodynamics laboratory for the performance of emergency coronary arteriography, which revealed occlusion in the proximal third of the anterior descending artery. Primary angioplasty followed by stent grafting was successfully performed. The patient had a satisfactory evolution (Killip I) and was discharged from the hospital on the seventh postinfarction day. We discuss here aspects of thrombolysis and coronary percutaneous interventions in the aged.

Published
2002

19. Diretrizes da Sociedade Brasileira de Cardiologia sobre Angina Instável e Infarto Agudo do Miocárdio sem Supradesnível do Segmento ST – 2021

Author

Nicolau, José Carlos, primary, Feitosa, Gilson Soares, additional, Petriz, João Luiz, additional, Furtado, Remo Holanda de Mendonça, additional, Précoma, Dalton Bertolim, additional, Lemke, Walmor, additional, Lopes, Renato Delascio, additional, Timerman, Ari, additional, Marin, José A., additional, Bezerra, Luiz, additional, Gomes, Bruno Ferraz de Oliveira, additional, Santos, Eduardo Cavalcanti Lapa, additional, Piegas, Leopoldo Soares, additional, Soeiro, Alexandre de Matos, additional, Negri, Alexandre Jorge de Andrade, additional, Franci, Andre, additional, Markman, Brivaldo, additional, Baccaro, Bruno Mendonça, additional, Montenegro, Carlos Eduardo Lucena, additional, Rochitte, Carlos Eduardo, additional, Barbosa, Carlos José Dornas Gonçalves, additional, Virgens, Cláudio Marcelo Bittencourt das, additional, Stefanini, Edson, additional, Manenti, Euler Roberto Fernandes, additional, Lima, Felipe Gallego, additional, Monteiro, Francisco das Chagas, additional, Correa, Harry, additional, Pena, Henrique Patrus Mundim, additional, Pinto, Ibraim Masciarelli Francisco, additional, Falcão, João Luiz de Alencar Araripe, additional, Sena, Joberto Pinheiro, additional, Peixoto, José Maria, additional, Souza, Juliana Ascenção de, additional, Silva, Leonardo Sara da, additional, Maia, Lilia Nigro, additional, Ohe, Louis Nakayama, additional, Baracioli, Luciano Moreira, additional, Dallan, Luís Alberto de Oliveira, additional, Dallan, Luis Augusto Palma, additional, Mattos, Luiz Alberto Piva e, additional, Bodanese, Luiz Carlos, additional, Ritt, Luiz Eduardo Fonteles, additional, Canesin, Manoel Fernandes, additional, Rivas, Marcelo Bueno da Silva, additional, Franken, Marcelo, additional, Magalhães, Marcos José Gomes, additional, Oliveira, Múcio Tavares de, additional, Filgueiras, Nivaldo Menezes, additional, Dutra, Oscar Pereira, additional, Coelho, Otávio Rizzi, additional, Leães, Paulo Ernesto, additional, Rossi, Paulo Roberto Ferreira, additional, Soares, Paulo Rogério, additional, Lemos, Pedro Alves, additional, Farsky, Pedro Silvio, additional, Cavalcanti, Rafael Rebêlo C., additional, Alves, Renato Jorge, additional, Kalil, Renato Abdala Karam, additional, Esporcatte, Roberto, additional, Marino, Roberto Luiz, additional, Giraldez, Roberto Rocha Corrêa Veiga, additional, Meneghelo, Romeu Sérgio, additional, Lima, Ronaldo de Souza Leão, additional, Ramos, Rui Fernando, additional, Falcão, Sandra Nivea dos Reis Saraiva, additional, Dalçóquio, Talia Falcão, additional, Lemke, Viviana de Mello Guzzo, additional, Chalela, William Azem, additional, and Mathias, Wilson, additional

Published
2021
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20. SAFETY AND EFFICACY OF DPP4 INHIBITORS IN ACUTE MYOCARDIAL INFARCTION: A BIOMARKER DRIVEN DOUBLE-BLINDED RANDOMIZED CONTROLLED TRIAL

Author

Genestreti, Paulo Rizzo, primary, Furtado, Remo, additional, Salsoso, Rocío, additional, Dalcoquio, Talia, additional, Nakashima, Carlos, additional, Lima, Viviane, additional, Colodetti, Raiza, additional, Ferrari, Aline, additional, Franci, Andre, additional, Menezes, Fernando, additional, Baracioli, Luciano, additional, and Nicolau, Jose, additional

Published
2021
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21. HIGH-DENSITY LIPOPROTEIN FUNCTION IN PATIENTS WITH TYPE 2 DIABETES: DIFFERENCES BETWEEN THE ACUTE AND CHRONIC PHASES OF CORONARY ARTERY DISEASE

Author

Genestreti, Paulo Rizzo, primary, Freitas, Fatima R., additional, Furtado, Remo, additional, Rodriguez, Rocio Salsoso, additional, Dalcoquio, Talia, additional, Tavoni, Thauany, additional, Nakashima, Carlos, additional, Ferrari, Aline Gehlen, additional, Colodetti, Raiza, additional, Menezes, Fernando, additional, Lima, Viviane, additional, Baracioli, Luciano, additional, Maranhao, Raul C., additional, and Nicolau, Jose, additional

Published
2021
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23. INFLUENCE OF HEALTH INSURANCE ON LONG-TERM ADHERENCE TO STATINS AND BETA-BLOCKERS AFTER ACUTE CORONARY SYNDROMES

Author

Nicolau, Jose Carlos, primary, Salsoso, Rocío, additional, Dalcoquio, Talia, additional, Genestreti, Paulo, additional, Franci, Andre, additional, Ferrari, Aline, additional, Bertolin, Adriadne, additional, Lara, Livia, additional, Juliasz, Marcela, additional, Pereira, Cesar, additional, Lima, Felipe, additional, Baracioli, Luciano, additional, Giraldez, Roberto, additional, and Furtado, Remo, additional

Published
2021
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24. Associação entre Terapia com Estatinas e Menor Incidência de Hiperglicemia em Pacientes Internados com Síndromes Coronarianas Agudas

Author

Furtado, Remo Holanda de Mendonça, primary, Genestreti, Paulo Rizzo, additional, Dalçóquio, Talia F., additional, Baracioli, Luciano Moreira, additional, Lima, Felipe Galego, additional, Franci, André, additional, Giraldez, Roberto R. C. V., additional, Menezes, Fernando R., additional, Ferrari, Aline Gehlen, additional, Lima, Viviane Moreira, additional, Pereira, Cesar A. C., additional, Nakashima, Carlos Alberto Kenji, additional, Salsoso, Rocio, additional, Godoy, Lucas Colombo, additional, and Nicolau, José C., additional

Published
2021
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25. Factors associated with actively working in the very long-term following acute coronary syndrome

Author

Nicolau, Jose C., primary, Furtado, Remo H.M., additional, Dalçóquio, Talia F., additional, Lara, Livia M., additional, Juliasz, Marcela G., additional, Ferrari, Aline G., additional, Nakashima, Carlos A.K., additional, Franci, Andre, additional, Pereira, Cesar A.C., additional, Lima, Felipe G., additional, Giraldez, Roberto R., additional, Salsoso, Rocío, additional, Baracioli, Luciano M., additional, and Goodman, Shaun, additional

Published
2021
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27. COMPARISON BETWEEN TWO DIFFERENT LOCAL HEMOSTASIS TECHNIQUES FOR DENTAL EXTRACTIONS IN PATIENTS ON DUAL ANTIPLATELET THERAPY: A WITHIN-PERSON, SINGLE-BLIND, RANDOMIZED TRIAL

Author

Guardieiro, Bruno, primary, Santos-Paul, Marcela A., additional, Salsoso, Rocío, additional, Dalçóquio, Talia, additional, Furtado, Remo, additional, Neves, Itamara L.I., additional, Neves, Ricardo S., additional, Filho, Cyrillo Cavalheiro, additional, Baracioli, Luciano, additional, and Nicolau, Jose C., additional

Published
2020
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28. ELECTRICAL STORM AND CARDIOGENIC SHOCK AFTER ACUTE CORONARY SYNDROME REVERTED WITH ECMO CASE REPORT

Author

Ferreira, Mayara Reis Cardoso, primary, Baracioli, Luciano Moreira, additional, Galas, Filomena Regina Barbosa Gomes, additional, Dalcoquio, Talia, additional, Furtado, Remo Holanda, additional, Baldo, Vanessa Maria Gomes Taques, additional, Soffiatti, Carla David, additional, Bertolin, Adriadne Justi, additional, Mustafa, Sumaia, additional, Sobreiro, Daniely Iadocico, additional, and Nicolau, Jose Carlos, additional

Published
2020
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29. IMPACT OF HIGH LIPOPROTEIN(A) LEVELS ON PLATELET AGGREGABILITY IN PATIENTS WITH STABLE CORONARY ARTERY DISEASE

Author

Salsoso, Rocío, primary, Dalçóquio, Talia, additional, Furtado, Remo, additional, Franci, Andre, additional, Barbosa, Carlos, additional, Genestreti, Paulo, additional, Ferreira, Mayara Reis Cardoso, additional, Strunz, Celia, additional, Baracioli, Luciano, additional, Maranhão, Raul Cavalcante, additional, and Nicolau, Jose Carlos, additional

Published
2020
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30. EFFECT OF EXERCISE TRAINING ON PLATELET AGGREGATION AND ON P2Y12 INHIBITOR RESISTANCE AFTER MYOCARDIAL INFARCTION: A RANDOMIZED CLINICAL TRIAL

Author

Dalçóquio, Talia, primary, de Mendonça Furtado, Remo Holanda, additional, Arantes, Flavia Bittar Britto Britto, additional, dos Santos, Mayara Alves, additional, Alves, Leandro Silva, additional, Rondon, Maria Urbana Pinto Brandão, additional, Ferreira-Santos, Larissa, additional, de Nazaré Nunes Alves, Maria Janieire, additional, Ferrari, Aline Gehlen, additional, Genestreti, Paulo Rizzo, additional, Baracioli, Luciano Moreira, additional, Franci, André, additional, Salsoso, Rocio, additional, Negrão, Carlos Eduardo, additional, and Nicolau, José Carlos, additional

Published
2020
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31. EFFECT OF TICAGRELOR AND CLOPIDOGREL ON CORONARY MICROCIRCULATION IN PATIENTS WITH ACUTE MYOCARDIAL INFARCTION

Author

Filho, Marco Antonio Scanavini, primary, Berwanger, Otavio, additional, Mathias, Wilson, additional, Aguiar, Miguel Osman, additional, Chiang, Hsu Po, additional, Baracioli, Luciano Moreira, additional, Lima, Felipe Gallego, additional, Menezes, Fernando Reis, additional, Dalçoquio, Talia, additional, Furtado, Remo Holanda M., additional, De Luca, Fabio Augusto, additional, Uezato, Delcio, additional, Ramires, Jose Antonio Franchini, additional, Filho, Roberto Kalil, additional, and Nicolau, Jose Carlos, additional

Published
2019
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32. INCREASED BODYWEIGHT AND INADEQUATE RESPONSE TO ASPIRIN IN INDIVIDUALS WITH CORONARY ARTERY DISEASE

Author

de Mendonca Furtado, Remo Holanda, primary, Arantes, Flavia, additional, Barbosa, Carlos, additional, Franci, Andre, additional, Menezes, Fernando, additional, Salsoso, Rocio, additional, Dalcoquio, Talia, additional, Nakashima, Carlos, additional, Filho, Marco Scanavini, additional, Ferrari, Aline, additional, Genestreti, Paulo, additional, Baracioli, Luciano, additional, and Nicolau, Jose C., additional

Published
2019
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33. O escore de risco de sangramento como preditor de mortalidade em pacientes com síndromes coronarianas agudas

Author

Nicolau, José Carlos, Moreira, Humberto Graner, Baracioli, Luciano Moreira, Serrano Jr, Carlos Vicente, Lima, Felipe Galego, Franken, Marcelo, Giraldez, Roberto Rocha, Ganem, Fernando, Kalil Filho, Roberto, Ramires, José Antônio Franchini, and Mehran, Roxana

Subjects
Hemorragia/mortalidade, Síndrome Coronariana Aguda, Probabilidade, lcsh:Diseases of the circulatory (Cardiovascular) system, lcsh:RC666-701, Hemorragia, Hemorrhage, Síndrome Coronariana Aguda/complicações, Acute Coronary Syndrome, Probability
Abstract

FUNDAMENTO: A ocorrência de sangramento aumenta a mortalidade intra-hospitalar em pacientes com síndromes coronarianas agudas (SCAs), e há uma boa correlação entre os escores de risco de sangramento e a incidência de eventos hemorrágicos. No entanto, o papel dos escores de risco de sangramento como fatores preditivos de mortalidade é pouco estudado. OBJETIVO: Analisar o papel do escore de risco de sangramento como fator preditivo de mortalidade intra-hospitalar numa coorte de pacientes com SCA tratados num centro terciário de cardiologia. MÉTODOS: Dos 1.655 pacientes com SCA (547 com SCA com supra de ST e 1.118 com SCA sem supra de ST), calculou-se o escore de risco de sangramento ACUITY/HORIZONS prospectivamente em 249 pacientes e retrospectivamente nos demais 1.416. Informações sobre mortalidade e complicações hemorrágicas também foram obtidas. RESULTADOS: A idade média da população estudada foi 64,3 ± 12,6 anos e o escore de risco de sangramento médio foi 18 ± 7,7. A correlação entre sangramento e mortalidade foi altamente significativa (p < 0,001; OR = 5,29), assim como a correlação entre escore de sangramento e hemorragia intra-hospitalar (p < 0,001; OR = 1,058), e entre escore de sangramento e mortalidade intra-hospitalar (OR ajustado = 1,121, p < 0,001, área sob a curva ROC 0,753; p < 0,001). O OR ajustado e a área sob a curva ROC para a população com SCA com supra de ST foram 1,046 (p = 0,046) e 0,686 ± 0,040 (p < 0,001), respectivamente, e para SCA sem supra de ST foram 1,150 (p < 0,001) e 0,769 ± 0,036 (p < 0,001), respectivamente. CONCLUSÃO: O escore de risco de sangramento é um fator preditivo muito útil e altamente confiável para mortalidade intra-hospitalar em uma grande variedade de pacientes com SCAs, especialmente aqueles com angina instável ou infarto agudo do miocárdio sem supra de ST. BACKGROUND: It is well known that the occurrence of bleeding increases in-hospital mortality in patients with acute coronary syndromes (ACS), and there is a good correlation between bleeding risk scores and bleeding incidence. However, the role of bleeding risk score as mortality predictor is poorly studied. OBJECTIVE: The main purpose of this paper was to analyze the role of bleeding risk score as in-hospital mortality predictor in a cohort of patients with ACS treated in a single cardiology tertiary center. METHODS: Out of 1655 patients with ACS (547 with ST-elevation ACS and 1118 with non-ST-elevation ACS), we calculated the ACUITY/HORIZONS bleeding score prospectively in 249 patients and retrospectively in the remaining 1416. Mortality information and hemorrhagic complications were also obtained. RESULTS: Among the mean age of 64.3 ± 12.6 years, the mean bleeding score was 18 ± 7.7. The correlation between bleeding and mortality was highly significant (p < 0.001, OR = 5.296), as well as the correlation between bleeding score and in-hospital bleeding (p < 0.001, OR = 1.058), and between bleeding score and in-hospital mortality (adjusted OR = 1.121, p < 0.001, area under the ROC curve 0.753, p < 0.001). The adjusted OR and area under the ROC curve for the population with ST-elevation ACS were, respectively, 1.046 (p = 0.046) and 0.686 ± 0.040 (p < 0.001); for non-ST-elevation ACS the figures were, respectively, 1.150 (p < 0.001) and 0.769 ± 0.036 (p < 0.001). CONCLUSIONS: Bleeding risk score is a very useful and highly reliable predictor of in-hospital mortality in a wide range of patients with acute coronary syndromes, especially in those with unstable angina or non-ST-elevation acute myocardial infarction.

Published
2013

34. THE ROLE OF ORAL BETA BLOCKER IN A REAL-WORLD POPULATION WITH NON-ST SEGMENT ELEVATION ACUTE CORONARY SYNDROMES

Author

Nicolau, Jose C., primary, Ferrari, Aline, additional, Coelho, Gabriela M.M., additional, Nakashima, Carlos A.K., additional, Lima, Viviane M., additional, Dalcoquio, Talia, additional, Furtado, Remo, additional, Menezes, Fernando, additional, Ramires, Jose, additional, Kalil-Filho, Roberto, additional, and Baracioli, Luciano, additional

Published
2017
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35. EFFECTS OF LOW MOLECULAR WEIGHT HEPARIN VERSUS DABIGATRAN ON PLATELET AGGREGATION IN PATIENTS WITH STABLE CORONARY ARTERY DISEASE

Author

Arantes, Flavia Bittar Britto, primary, Menezes, Fernando, additional, Franci, Andre, additional, Barbosa, Carlos, additional, Dalçoquio, Talia F., additional, Nakashima, Carlos K., additional, Ferrari, Aline, additional, Filho, Marco Scanavini, additional, Furtado, Remo, additional, Baracioli, Luciano, additional, Ramires, Jose, additional, Kalil-Filho, Roberto, additional, and Nicolau, Jose, additional

Published
2017
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36. Resumo Executivo: Diretrizes da SBC sobre Angina Instável e Infarto Agudo do Miocárdio Sem Supradesnível do Segmento ST

Author

Feitosa-Filho,Gilson Soares, Baracioli,Luciano Moreira, Barbosa,Carlos José Dornas G., Franci,André, Timerman,Ari, Soares Piegas,Leopoldo, Marin-Neto,José Antônio, and Nicolau,José Carlos

Subjects
Troponin / therapeutic use, Angina Instável / fisiopatologia, Infarto do Miocárdio / mortalidade, Angina, Unstable / physiopathology, Troponina / uso terapêutico, Myocardial Infarction / mortality
Published
2015

37. Do Diabetic Patients with Acute Coronary Syndromes Have a Higher Threshold for Ischemic Pain?

Author

Nicolau, José Carlos, Barbosa, Carlos José Dornas Gonçalves, Franci, André, Baracioli, Luciano Moreira, Franken, Marcelo, Lima, Felipe Gallego, Giraldez, Roberto Rocha, Kalil Filho, Roberto, Ramires, José Antônio Franchini, and Giugliano, Robert P.

Subjects
Síndrome Coronariana Aguda, Chest Pain, Hyperglycemia, Diabetes Mellitus, Dor no Peito, Acute Coronary Syndrome, Hiperglicemia
Abstract

Background: Data from over 4 decades have reported a higher incidence of silent infarction among patients with diabetes mellitus (DM), but recent publications have shown conflicting results regarding the correlation between DM and presence of pain in patients with acute coronary syndromes (ACS). Objective: Our primary objective was to analyze the association between DM and precordial pain at hospital arrival. Secondary analyses evaluated the association between hyperglycemia and precordial pain at presentation, and the subgroup of patients presenting within 6 hours of symptom onset. Methods: We analyzed a prospectively designed registry of 3,544 patients with ACS admitted to a Coronary Care Unit of a tertiary hospital. We developed multivariable models to adjust for potential confounders. Results: Patients with precordial pain were less likely to have DM (30.3%) than those without pain (34.0%; unadjusted p = 0.029), but this difference was not significant after multivariable adjustment, for the global population (p = 0.84), and for subset of patients that presented within 6 hours from symptom onset (p = 0.51). In contrast, precordial pain was more likely among patients with hyperglycemia (41.2% vs 37.0% without hyperglycemia, p = 0.035) in the overall population and also among those who presented within 6 hours (41.6% vs. 32.3%, p = 0.001). Adjusted models showed an independent association between hyperglycemia and pain at presentation, especially among patients who presented within 6 hours (OR = 1.41, p = 0.008). Conclusion: In this non-selected ACS population, there was no correlation between DM and hospital presentation without precordial pain. Moreover, hyperglycemia correlated significantly with pain at presentation, especially in the population that arrived within 6 hours from symptom onset. Fundamento: Dados de mais de 4 décadas relataram maior incidência de infarto silencioso entre os pacientes com diabetes mellitus (DM), mas publicações recentes mostraram resultados conflitantes quanto à correlação entre DM e presença de dor em pacientes com síndromes coronárias agudas (SCA). Objetivo: Nosso objetivo principal foi analisar a associação entre dor precordial e DM na chegada ao hospital. Análises secundárias avaliaram a associação entre hiperglicemia e dor precordial na apresentação, e o subgrupo de pacientes que se apresentaram em até 6 horas após o início dos sintomas. Métodos: Analisamos um registro prospectivo de 3.544 pacientes com SCA internados em unidade coronária de um hospital terciário. Desenvolvemos modelos multivariados para ajustar potenciais fatores de confusão. Resultados: Os pacientes com dor precordial eram menos propensos a ter DM (30,3%) do que aqueles sem dor (34,0 %, p não ajustado = 0,029), mas essa diferença não foi significativa após ajuste multivariado, para a população global (p = 0,84), e para o subgrupo de pacientes que se apresentaram dentro do período de 6 horas após o início dos sintomas (p = 0,51). Em contraste, a dor precordial era mais provável entre os pacientes com hiperglicemia (41,2% vs. 37,0% sem hiperglicemia, p = 0,035) na população total, e também entre aqueles que se apresentaram no período de 6 horas (41,6% vs. 32,3%, p = 0,001). Modelos ajustados mostraram uma associação independente entre hiperglicemia e dor na apresentação, especialmente entre os pacientes que se apresentaram no período de até 6 horas (OR = 1,41, p = 0,008). Conclusão: Nesta população não-selecionada com SCA, não houve correlação entre DM e a apresentação no hospital sem dor precordial. Além disso, a hiperglicemia foi correlacionada de forma significativa com a dor na apresentação, especialmente na população que chegou dentro do período de até 6 horas após o início dos sintomas.

Published
2014

38. Oclusão de comunicação interventricular pós-infarto com prótese percutânea CERA

Author

Ribeiro, Henrique Barbosa, Baracioli, Luciano Moreira, Kajita, Luiz Junya, Pinheiro, Martina Battistini, Ribeiro, Expedito E., and Nicolau, José Carlos

Subjects
Myocardial infarction, septal occluder device, heart septal defects, ventricular, Infarto do miocárdio, comunicação interventricular/mortalidade, dispositivo para oclusão septal, comunicação interventricular, comunicação interventricular/cirurgia
Published
2012

41. II Diretriz Brasileira de insuficiência cardíaca aguda

Author

Montera, Marcelo Westerlund, Almeida, Dirceu Rodrigues de, Mesquita, Evandro Tinoco, Rocha, Ricardo Mourilhe, Moura, Lídia Ana Zytynski, Réa Neto, Álvaro, Pereira, Sabrina Bernardez, Mangini, Sandrigo, Braga, Fabiana Goulart Marcondes, Albuquerque, Denílson Campos de, Stefanini, Edson, Saad, Eduardo Benchimol, Vilas-Boas, Fábio, Silva, Fabrício Braga da, Ramires, Felix José Alvarez, Soriano, Francisco Garcia, Westphal, Glauco Adrieno, Ribeiro, Gustavo Calado de Aguiar, Almeida Júnior, Gustavo Luiz Gouvêa de, Villacorta Júnior, Humberto, Souza Neto, João David de, Costa, João Luiz Ferreira, Rossi Neto, João Manoel, Baracioli, Luciano Moreira, Silva Neto, Luís Beck da, Camanho, Luiz Eduardo, Bittencourt, Marcelo Imbroinise, Garcia, Marcelo Iório, Moreira, Maria da Consolação Vieira, Moritz, Rachel Duarte, Oliveira, Ricardo Guerra Gusmão de, Martins, Silvia Marinho, Bordignon, Solange, and Fiorelli, Alfredo Inacio

Subjects
Insuficiência cardíaca, Normas
Abstract

Resumo não disponível

Published
2009

42. The influence of health insurance plans on the long term outcome of patients with acute myocardial infarction

Author

Nicolau,José Carlos, Baracioli,Luciano Moreira, Serrano Jr.,Carlos Vicente, Giraldez,Roberto Rocha, Kalil Filho,Roberto, Lima,Felipe Galego, Franken,Marcelo, Ganem,Fernando, Lage,Rony Lopes, and Truffa,Rodrigo

Subjects
planos de saúde, Myocardial infarction, Infarto do miocárdio, health plans, seguimentos, follow-up studies
Abstract

FUNDAMENTO: Pouco se sabe, principalmente em nosso meio, sobre a influência dos planos de saúde na evolução a longo prazo pós-infarto agudo do miocárdio (IAM). OBJETIVO: Avaliar a evolução de pacientes com IAM usuários do SUS ou de outros convênios. MÉTODOS: Foram analisados 1588 pacientes com IAM (idade média de 63,3 ± 12,9 anos, 71,7% homens), incluídos de forma prospectiva em banco de dados específico, e seguidos por até 7,55 anos. Deste total, 1003 foram alocados no "grupo SUS" e 585 no "outros convênios". Qui-quadrado, log-rank e Cox ("stepwise") foram aplicados nas diferentes análises estatísticas. O modelo multivariado a longo prazo, com mortalidade como variável dependente, incluiu 18 variáveis independentes. RESULTADOS: As mortalidades hospitalares nos grupos "outros convênios" e "SUS" foram de 11,4% e 10,3%, respectivamente (P=0,5); a longo prazo, as chances de sobrevivência nos grupos foram, respectivamente, de 70,4% ± 2,9 e 56,4% ± 4,0 (P=0,001, "hazard-ratio"=1,43, ou 43% a mais de chance de óbito no grupo "SUS"). No modelo ajustado, o grupo "SUS" permaneceu com probabilidade significativamente maior de óbito (36% a mais de chance, P=0,005), demonstrando-se ainda que cirurgia de revascularização miocárdica e angioplastia melhoraram o prognóstico dos pacientes, ao passo que idade e história de infarto prévio, diabete ou insuficiência cardíaca, pioraram o prognóstico dos mesmos. CONCLUSÃO: Em relação a usuários de outros convênios, o usuário SUS apresenta mortalidade similar durante a fase hospitalar, porém tem pior prognóstico a longo prazo, reforçando a necessidade de esforços adicionais no sentido de melhorar o nível de atendimento destes pacientes após a alta hospitalar. BACKGROUND: Little is known, especially in our country, about the influence of health insurance plans on the long term outcome of patients after acute myocardial infarction (AMI). OBJECTIVE: To assess the outcome of patients with AMI who are covered by the National Health System (SUS) or other health insurance plans. METHODS: We analyzed 1,588 patients with AMI (mean age of 63.3 + 12.9 years, 71.7% male) who were included prospectively into a specific database and followed up for up to 7.55 years. Of this total, 1,003 were placed in the "SUS" group and 585 in the "other insurance plans" group. We applied chi-square, log-rank and Cox (stepwise) to the different statistical analyses. The long term multivariate model with mortality as a dependent variable included 18 independent variables. RESULTS: In-hospital mortality rates in the "other insurance plans" and "SUS" groups were 11.4% and 10.3%, respectively (p = 0.5); in the long term, survival chances in the groups were respectively, 70.4% + 2.9 and 56.4% + 4.0 (p = 0.001, hazard-ratio = 1.43, or a 43% higher chance of death in the "SUS" group). In the adjusted model, the "SUS" group had a significantly higher chance of death (a 36% higher chance, p = 0.005). Surgical revascularization and angioplasty improved the prognosis of these patients, whereas age and previous history of infarction, diabetes or heart failure worsened the prognosis. CONCLUSIONS: Relative to patients with other insurance plans, SUS users present similar mortality rates during hospital stay, but their prognosis is worse in the long term, thus reinforcing the need for additional efforts to improve the care provided to these patients after hospital discharge.

Published
2008

46. Do Diabetic Patients with Acute Coronary Syndromes Have a Higher Threshold for Ischemic Pain?

Author

Nicolau, José Carlos, primary, Barbosa, Carlos José Dornas Gonçalves, additional, Franci, André, additional, Baracioli, Luciano Moreira, additional, Franken, Marcelo, additional, Lima, Felipe Gallego, additional, Giraldez, Roberto Rocha, additional, Kalil Filho, Roberto, additional, Ramires, José Antônio Franchini, additional, and Giugliano, Robert P., additional

Published
2014
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47. Primary coronary angioplasty in a nonagenarian

Author

Baracioli,Luciano M., Serrano Jr,Carlos V., Esteves,Antônio, Ciporkin,Jean Pierre, and Nicolau,José Carlos

Subjects
cardiovascular diseases
Abstract

A woman aged 98 years entered the tertiary hospital service with a picture of acute myocardial infarction of the extensive anterior wall, which began 4 hours earlier. Due to the large myocardial risk area suggested by the electrocardiogram, the patient was taken to the hemodynamics laboratory for the performance of emergency coronary arteriography, which revealed occlusion in the proximal third of the anterior descending artery. Primary angioplasty followed by stent grafting was successfully performed. The patient had a satisfactory evolution (Killip I) and was discharged from the hospital on the seventh postinfarction day. We discuss here aspects of thrombolysis and coronary percutaneous interventions in the aged.

Published
2002

49. The Bleeding Risk Score as a Mortality Predictor in Patients with Acute Coronary Syndrome

Author

Nicolau, José Carlos, primary, Moreira, Humberto Graner, additional, Baracioli, Luciano Moreira, additional, Serrano Junior, Carlos Vicente, additional, Lima, Felipe Galego, additional, Franken, Marcelo, additional, Giraldez, Roberto Rocha, additional, Ganem, Fernando, additional, Kalil Filho, Roberto, additional, Ramires, José Antônio Franchini, additional, and Mehran, Roxana, additional

Published
2013
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50. Unrecognized Diabetes and Myocardial Necrosis: Predictors of Hyperglycemia in Myocardial Infarction

Author

Ladeira, Renata Teixeira, primary, Baracioli, Luciano Moreira, additional, Faulin, Tanize Espírito Santo, additional, Abdalla, Dulcinéia Saes Parra, additional, Seydell, Talita Matttos, additional, Maranhão, Raul Cavalcante, additional, Mendonça, Berenice Bilharinho, additional, Strunz, Célia Cassaro, additional, Castro, Isac de, additional, and Nicolau, José Carlos, additional

Published
2013
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