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113 results on '"Baptista, Daniela"'

1. Genome-wide association meta-analyses and fine-mapping elucidate pathways influencing albuminuria.

Author

Teumer, Alexander, Li, Yong, Ghasemi, Sahar, Prins, Bram P, Wuttke, Matthias, Hermle, Tobias, Giri, Ayush, Sieber, Karsten B, Qiu, Chengxiang, Kirsten, Holger, Tin, Adrienne, Chu, Audrey Y, Bansal, Nisha, Feitosa, Mary F, Wang, Lihua, Chai, Jin-Fang, Cocca, Massimiliano, Fuchsberger, Christian, Gorski, Mathias, Hoppmann, Anselm, Horn, Katrin, Li, Man, Marten, Jonathan, Noce, Damia, Nutile, Teresa, Sedaghat, Sanaz, Sveinbjornsson, Gardar, Tayo, Bamidele O, van der Most, Peter J, Xu, Yizhe, Yu, Zhi, Gerstner, Lea, Ärnlöv, Johan, Bakker, Stephan JL, Baptista, Daniela, Biggs, Mary L, Boerwinkle, Eric, Brenner, Hermann, Burkhardt, Ralph, Carroll, Robert J, Chee, Miao-Li, Chee, Miao-Ling, Chen, Mengmeng, Cheng, Ching-Yu, Cook, James P, Coresh, Josef, Corre, Tanguy, Danesh, John, de Borst, Martin H, De Grandi, Alessandro, de Mutsert, Renée, de Vries, Aiko PJ, Degenhardt, Frauke, Dittrich, Katalin, Divers, Jasmin, Eckardt, Kai-Uwe, Ehret, Georg, Endlich, Karlhans, Felix, Janine F, Franco, Oscar H, Franke, Andre, Freedman, Barry I, Freitag-Wolf, Sandra, Gansevoort, Ron T, Giedraitis, Vilmantas, Gögele, Martin, Grundner-Culemann, Franziska, Gudbjartsson, Daniel F, Gudnason, Vilmundur, Hamet, Pavel, Harris, Tamara B, Hicks, Andrew A, Holm, Hilma, Foo, Valencia Hui Xian, Hwang, Shih-Jen, Ikram, M Arfan, Ingelsson, Erik, Jaddoe, Vincent WV, Jakobsdottir, Johanna, Josyula, Navya Shilpa, Jung, Bettina, Kähönen, Mika, Khor, Chiea-Chuen, Kiess, Wieland, Koenig, Wolfgang, Körner, Antje, Kovacs, Peter, Kramer, Holly, Krämer, Bernhard K, Kronenberg, Florian, Lange, Leslie A, Langefeld, Carl D, Lee, Jeannette Jen-Mai, Lehtimäki, Terho, Lieb, Wolfgang, Lim, Su-Chi, Lind, Lars, Lindgren, Cecilia M, Liu, Jianjun, and Loeffler, Markus

Subjects
Animals, Humans, Drosophila melanogaster, Albuminuria, Diabetes Mellitus, Genetic Predisposition to Disease, Creatinine, Risk Factors, Chromosome Mapping, Gene Expression Regulation, Meta-Analysis as Topic, Genome-Wide Association Study, Genetic Loci, Phenomics
Abstract

Increased levels of the urinary albumin-to-creatinine ratio (UACR) are associated with higher risk of kidney disease progression and cardiovascular events, but underlying mechanisms are incompletely understood. Here, we conduct trans-ethnic (n = 564,257) and European-ancestry specific meta-analyses of genome-wide association studies of UACR, including ancestry- and diabetes-specific analyses, and identify 68 UACR-associated loci. Genetic correlation analyses and risk score associations in an independent electronic medical records database (n = 192,868) reveal connections with proteinuria, hyperlipidemia, gout, and hypertension. Fine-mapping and trans-Omics analyses with gene expression in 47 tissues and plasma protein levels implicate genes potentially operating through differential expression in kidney (including TGFB1, MUC1, PRKCI, and OAF), and allow coupling of UACR associations to altered plasma OAF concentrations. Knockdown of OAF and PRKCI orthologs in Drosophila nephrocytes reduces albumin endocytosis. Silencing fly PRKCI further impairs slit diaphragm formation. These results generate a priority list of genes and pathways for translational research to reduce albuminuria.

Published
2019

5. Performance and Durability of Paints for the Conservation of Historic Façades.

Author

Melo, Rodrigo Henryque Reginato Quevedo, Falcão, Juliane Rodrigues, Bersch, Jéssica Deise, Baptista, Daniela Tatsch, and Masuero, Angela Borges

Subjects
ACRYLIC paint, PRESERVATION of painting, PRESERVATION of historic buildings, PRESERVATION of materials, HISTORIC preservation, AIR-entrained concrete, CONCRETE slabs, CONSTRUCTION slabs
Abstract

This paper analyzes the performance of various types of paints available in the Brazilian market, including PVA, matte acrylic, silicate, and lime paints within the context of their applicability to the conservation of historic building facades. Considering distinct suppliers and application methods, this study highlights the importance of tailoring paint selection to the preservation requirements of historic edifices, taking into account local preservation norms and the material characteristics of the buildings' original construction. The paints were evaluated based on water vapor permeability, washability, and adhesion. Furthermore, the paints' color variation with exposure to accelerated artificial aging was assessed. For testing purposes, specimens produced from cellular concrete slabs were used as substrates, which were coated with the paints under study. Based on the results, it was observed that, regarding the diffusion of water vapor, the silicate and lime paints presented the highest permeability values, and the acrylic and PVA paints had the lowest. Concerning washability, the silicate and lime paints showed the greatest wear. The adhesion tests revealed that, except for lime paint, detachment often occurred at the substrate. As for the accelerated aging test, lime paint exhibited the most significant color variation, losing its pigmentation considerably over time. With the results of this research and considering the main preservation requirements of historic coatings, silicate-based paints may be considered the most suitable. [ABSTRACT FROM AUTHOR]

Published
2024
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7. Sensory-evoked LTP driven by dendritic plateau potentials in vivo

Author

Gambino, Frederic, Pages, Stephane, Kehayas, Vassilis, Baptista, Daniela, Tatti, Roberta, Carleton, Alan, and Holtmaat, Anthony

Subjects
Physiological aspects, Research, Synaptic transmission -- Physiological aspects -- Research, Somatosensory evoked potentials -- Physiological aspects -- Research, Evoked potentials (Electrophysiology) -- Physiological aspects -- Research, Neural transmission -- Physiological aspects -- Research
Abstract

In most cortical synaptic LTP studies in vivo, strong postsynaptic depolarization was provided by action-potential-triggering somatic current injections (3). To examine whether sensory stimuli can elicit LTP of synaptic inputs [...], Long-term synaptic potentiation (LTP) is thought to be a key process in cortical synaptic network plasticity and memory formation (1). Hebbian forms of LTP depend on strong postsynaptic depolarization, which in many models is generated by action potentials that propagate back from the soma into dendrites (2,3). However, local dendritic depolarization has been shown to mediate these forms of LTP as well (1,4,5). As pyramidal cells in supragranular layers of the somatosensory cortex spike infrequently (6-8), it is unclear which of the two mechanisms prevails for those cells in vivo. Using whole-cell recordings in the mouse somatosensory cortex in vivo, we demonstrate that rhythmic sensory whisker stimulation efficiently induces synaptic LTP in layer 2/3 (L2/3) pyramidal cells in the absence of somatic spikes. The induction of LTP depended on the occurrence of NMDAR (N-methyl-D-aspartate receptor)-mediated long-lasting depolarizations, which bear similarities to dendritic plateau potentials (9-13). In addition, we show that whisker stimuli recruit synaptic networks that originate from the posteromedial complex of the thalamus (POm). Photostimulation of channelrhodopsin-2 expressing POm neurons generated NMDAR-mediated plateau potentials, whereas the inhibition of POm activity during rhythmic whisker stimulation suppressed the generation of those potentials and prevented whisker-evoked LTP. Taken together, our data provide evidence for sensory-driven synaptic LTP in vivo, in the absence of somatic spiking. Instead, LTP is mediated by plateau potentials that are generated through the cooperative activity of lemniscal and paralemniscal synaptic circuitry (14-16).

Published
2014

8. Single-Cell Analysis Uncovers Osteoblast Factor Growth Differentiation Factor 10 as Mediator of Vascular Smooth Muscle Cell Phenotypic Modulation Associated with Plaque Rupture in Human Carotid Artery Disease

Author

Brandt, Karim J., primary, Burger, Fabienne, additional, Baptista, Daniela, additional, Roth, Aline, additional, Fernandes da Silva, Rafaela, additional, Montecucco, Fabrizio, additional, Mach, Francois, additional, and Miteva, Kapka, additional

Published
2022
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11. Evaluation of sustainable solutions for water supply and sewage treatment in small municipalities using gradients of urban density

Author

Baptista, Daniela Tatsch, Sattler, Miguel Aloysio, Silva, Alline Gomes Lamenha e, and Stein, Márcia de Morais

Subjects
Densidades Populacionais, Sustentabilidade Urbana, Abastecimento de Água, Efluentes Domésticos
Abstract

Com o crescimento urbano, torna-se necessário definir as formas de atendimento à necessidade humana por água, em qualidade e quantidade adequadas. O presente artigo busca identificar como os gradientes de densidades populacionais podem contribuir na definição de soluções sustentáveis para o suprimento de água e tratamento de esgoto em pequenas municipalidades. Partiu-se da definição das áreas estratégicas, em termos de sustentabilidade, buscando-se determinar, com base em dados gratuitos e publicamente disponíveis, a densidade urbana do município de Feliz/RS, bem como a distribuição do abastecimento de água e destinação dos efluentes domésticos. A partir desse diagnóstico, que considera as particularidades do município, foram propostas soluções alternativas e descentralizadas para as áreas avaliadas. Os resultados mostram que a avaliação integrada e espacial pode conduzir a soluções mais sustentáveis, que envolvam e empoderem a comunidade local quanto ao uso e cuidado com a água e como potencial de suporte à tomada de decisão. As cities grow, it becomes necessary to define ways of meeting the human need for water in adequate quality and quantity. In this article, it was identified how population densities gradients can contribute to the definition of sustainable solutions for water supply and sewage treatment in small municipalities. Strategic areas were defined in terms of sustainability, seeking to determine, based on free and public data, the urban density of the municipality of Feliz/RS and the distribution of water supply and solutions for domestic effluents. Based on this diagnosis, which considers the particularities of the municipality, alternative and decentralized solutions were proposed for the assessed areas. The results show that the integrated and spatial assessment can lead to more sustainable solutions, which involve and empower the local community regarding the use and care of water and with the potential to support decision making

Published
2020

14. A catalog of genetic loci associated with kidney function from analyses of a million individuals

Author

Wuttke, Matthias, Li, Yong, Li, Man, Sieber, Karsten B., Feitosa, Mary F., Gorski, Mathias, Tin, Adrienne, Wang, Lihua, Chu, Audrey Y., Hoppmann, Anselm, Kirsten, Holger, Giri, Ayush, Chai, Jin-Fang, Sveinbjornsson, Gardar, Tayo, Bamidele O., Nutile, Teresa, Fuchsberger, Christian, Marten, Jonathan, Cocca, Massimiliano, Ghasemi, Sahar, Xu, Yizhe, Horn, Katrin, Noce, Damia, van der Most, Peter J., Sedaghat, Sanaz, Yu, Zhi, Akiyama, Masato, Afaq, Saima, Ahluwalia, Tarunveer S., Almgren, Peter, Amin, Najaf, Ärnlöv, Johan, Bakker, Stephan J. L., Bansal, Nisha, Baptista, Daniela, Bergmann, Sven, Biggs, Mary L., Biino, Ginevra, Boehnke, Michael, Boerwinkle, Eric, Boissel, Mathilde, Bottinger, Erwin P., Boutin, Thibaud S., Brenner, Hermann, Brumat, Marco, Burkhardt, Ralph, Butterworth, Adam S., Campana, Eric, Campbell, Archie, Campbell, Harry, Canouil, Mickaël, Carroll, Robert J., Catamo, Eulalia, Chambers, John C., Chee, Miao-Ling, Chee, Miao-Li, Chen, Xu, Cheng, Ching-Yu, Cheng, Yurong, Christensen, Kaare, Cifkova, Renata, Ciullo, Marina, Pina Concas, Maria, Cook, James P., Coresh, Josef, Corre, Tanguy, Sala, Cinzia Felicita, Cusi, Daniele, Danesh, John, Daw, E. Warwick, de Borst, Martin H., De Grandi, Alessandro, de Mutsert, Renée, de Vries, Aiko P. J., Degenhardt, Frauke, Delgado, Graciela, Demirkan, Ayse, Di Angelantonio, Emanuele, Dittrich, Katalin, Divers, Jasmin, Dorajoo, Rajkumar, Eckardt, Kai-Uwe, Ehret, Georg, Elliott, Paul, Endlich, Karlhans, Evans, Michele K., Felix, Janine F., Foo, Valencia Hui Xian, Franco, Oscar H., Franke, Andre, Freedman, Barry I., Freitag-Wolf, Sandra, Friedlander, Yechiel, Froguel, Philippe, Gansevoort, Ron T., Gao, He, Gasparini, Paolo, Gaziano, J. Michael, Giedraitis, Vilmantas, Gieger, Christian, Girotto, Giorgia, Giulianini, Franco, Gögele, Martin, Gordon, Scott D., Gudbjartsson, Daniel F., Gudnason, Vilmundur, Haller, Toomas, Hamet, Pavel, Harris, Tamara B., Hartman, Catharina A., Hayward, Caroline, Hellwege, Jacklyn N., Heng, Chew-Kiat, Hickst, Andrew A., Hofer, Edith, Huang, Wei, Hutri-Kähönen, Nina, Hwang, Shih-Jen, ikram, M. Arfan, indridason, Olafur S., Ingelsson, Erik, ising, Marcus, Jaddoe, Vincent W. V., Jakobsdottir, Johanna, Jonas, Jost B, Joshi, Peter K., Shilpa Josyula, Navya, Jung, Bettina, Kähönen, Mika, Kamatani, Yoichiro, Kammerer, Candace M., Kanai, Masahiro, Kastarinen, Mika, Kerr, Shona M., Khor, Chiea-Chuen, Kiess, Wieland, Kleber, Marcus E., Koenig, Wolfgang, Kooner, Jaspal S., Körner, Antje, Kovacs, Peter, Kraja, Aldi T., Krajcoviechova, Alena, Kramer, Holly, Krämer, Bernhard K., Kronenberg, Florian, Kubo, Michiaki, Kühnel, Brigitte, Kuokkanen, Mikko, Kuusisto, Johanna, La Bianca, Martina, Laakso, Markku, Lange, Leslie A., Langefeld, Carl D., Jen-Mai Lee, Jeannette, Lehne, Benjamin, Lehtimäki, Terho, Lieb, Wolfgang, Cohort Study, Lifelines, Lim, Su-Chi, Lind, Lars, Lindgren, Cecilia M., Liu, Jun, Liu, Jianjun, Loeffler, Markus, Loos, Ruth J. F., Lucae, Susanne, Ann Lukas, Mary, Lyytikäinen, Leo-Pekka, Mägi, Reedik, Magnusson, Patrik K. E., Mahajan, Anubha, Martin, Nicholas G., Martins, Jade, März, Winfried, Mascalzoni, Deborah, Matsuda, Koichi, Christa Meisinger, Meitinger, Thomas, Melander, Olle, Metspalu, Andres, Mikaelsdottir, Evgenia K., Milaneschi, Yuri, Miliku, Kozeta, Mishra, Pashupati P., Veteran Program, V. A. Million, Mohlke, Karen L., Mononen, Nina, Montgomery, Grant W., Mook-Kanamori, Dennis O., Mychaleckyj, Josyf C., Nadkarni, Girish N, Nalls, Mike A., Nauck, Matthias, Nikus, Kjell, Ning, Boting, Nolte, ilja M., Noordam, Raymond, O’Connell, Jeffrey, O’Donoghue, Michelle L., Olafsson, Isleifur, Oldehinkel, Albertine J., Orho-Melander, Marju, Ouwehand, Willem H., Padmanabhan, Sandosh, Palmer, Nicholette D., Palsson, Runolfur, Penninx, Brenda W. J. H., Perls, Thomas, Perola, Markus, Pirastu, Mario, Pirastu, Nicola, Pistis, Giorgio, Podgornaia, Anna I., Polasek, Ozren, Ponte, Belen, Porteous, David J., Poulain, Tanja, Pramstaller, Peter P., Preuss, Michael H., Prins, Bram P., Province, Michael A., Rabelink, Ton J., Raffield, Laura M., Raitakari, Olli T., Reilly, Dermot F., Rettig, Rainer, Rheinberger, Myriam, Rice, Kenneth M., Ridker, Paul M., Rivadeneira, Fernando, Rizzi, Federica, Roberts, David J., Robino, Antonietta, Rossing, Peter, Rudan, Igor, Rueedi, Rico, Ruggiero, Daniela, Ryan, Kathleen A., Saba, Yasaman, Sabanayagam, Charumathi, Salomaa, Veikko, Salvi, Erika, Saum, Kai-Uwe, Schmidt, Helena, Schmidt, Reinhold, Schöttker, Ben, Schulz, Christina-Alexandra, Schupf, Nicole, Shaffer, Christian M., Shi, Yuan, Smith, Albert V., Smith, Blair H., Soranzo, Nicole, Spracklen, Cassandra N., Strauch, Konstantin, Stringham, Heather M., Stumvoll, Michael, Svensson, Per O., Szymczak, Silke, Tai, E-Shyong, Tajuddin, Salman M., Tan, Nicholas Y. Q., Taylor, Kent D., Teren, Andrej, Tham, Yih-Chung, Thiery, Joachim, Thio, Chris H. L., Thomsen, Hauke, Thorleifsson, Gudmar, Toniolo, Daniela, Tönjes, Anke, Tremblay, Johanne, Tzoulaki, Ioanna, Uitterlinden, André G., Vaccargiu, Simona, van Dam, Rob M., van der Harst, Pim, van Duijn, Cornelia M., Velez Edward, Digna R., Verweij, Niek, Vogelezang, suzanne, Völker, üwe, Vollenweider, Peter, Waeber, Gerard, Waldenberger, Melanie, Wallentin, Lars, Wang, Ya Xing, Wang, Chaolong, Waterworth, Dawn M., Bin Wei, Wen, White, Harvey, Whitfield, John B., Wild, Sarah H., Wilson, James F., Wojczynski, Mary K., Wong, Charlene, Wong, Tien-Yin, Xu, Liang, Yang, Qiong, Yasuda, Masayuki, Yerges-Armstrong, Laura M., Zhang, Weihua, Zonderman, Alan B., Rotter, Jerome I., Bochud, Murielle, Psaty, Bruce M., Vitart, Veronique, Wilson, James G., Dehghan, Abbas, Parsa, Afshin, Chasman, Daniel I., Ho, Kevin, Morris, Andrew P., Devuyst, Olivier, Akilesh, Shreeram, Pendergrass, Sarah A., Sim, Xueling, Böger, Carsten A., Okada, Yukinori, Edwards, Todd L., Snieder, Harold, Stefansson, Kari, Hung, Adriana M., Heid, Iris M., Markus Scholz, Teumer, Alexander, Köttgen, Anna, Pattaro, Cristian, Groningen Institute for Organ Transplantation (GIOT), Lifestyle Medicine (LM), Groningen Kidney Center (GKC), Cardiovascular Centre (CVC), Interdisciplinary Centre Psychopathology and Emotion regulation (ICPE), Life Course Epidemiology (LCE), Internal Medicine, Epidemiology, Erasmus MC other, Pediatrics, Psychiatry, APH - Mental Health, APH - Digital Health, Wuttke, M, Li, Y, Li, M, Sieber, Kb, Feitosa, Mf, Gorski, M, Tin, A, Wang, L, Chu, Ay, Hoppmann, A, Kirsten, H, Giri, A, Chai, Jf, Sveinbjornsson, G, Tayo, Bo, Nutile, T, Fuchsberger, C, Marten, J, Cocca, M, Ghasemi, S, Xu, Y, Horn, K, Noce, D, van der Most, Pj, Sedaghat, S, Yu, Z, Akiyama, M, Afaq, S, Ahluwalia, T, Almgren, P, Amin, N, Ärnlöv, J, Bakker, Sjl, Bansal, N, Baptista, D, Bergmann, S, Biggs, Ml, Biino, G, Boehnke, M, Boerwinkle, E, Boissel, M, Bottinger, Ep, Boutin, T, Brenner, H, Brumat, M, Burkhardt, R, Butterworth, A, Campana, Eric, Campbell, A, Campbell, H, Canouil, M, Carroll, Rj, Catamo, E, Chambers, Jc, Chee, Ml, Chen, X, Cheng, Cy, Cheng, Y, Christensen, K, Cifkova, R, Ciullo, M, Concas, Mp, Cook, Jp, Coresh, J, Corre, T, Sala, Cf, Cusi, D, Danesh, J, Daw, Ew, de Borst, Mh, De Grandi, A, de Mutsert, R, de Vries, Apj, Degenhardt, F, Delgado, G, Demirkan, A, Di Angelantonio, E, Dittrich, K, Divers, J, Dorajoo, R, Eckardt, Ku, Ehret, G, Elliott, P, Endlich, K, Evans, Mk, Felix, Jf, Foo, Vhx, Franco, Oh, Franke, A, Freedman, Bi, Freitag-Wolf, S, Friedlander, Y, Froguel, P, Gansevoort, Rt, Gao, H, Gasparini, P, Gaziano, Jm, Giedraitis, V, Gieger, C, Girotto, G, Giulianini, F, Gögele, M, Gordon, Sd, Gudbjartsson, Df, Gudnason, V, Haller, T, Hamet, P, Harris, Tb, Hartman, Ca, Hayward, C, Hellwege, Jn, Heng, Ck, Hicks, Aa, Hofer, E, Huang, W, Hutri-Kähönen, N, Hwang, Sj, Ikram, Ma, Indridason, O, Ingelsson, E, Ising, M, Jaddoe, Vwv, Jakobsdottir, J, Jonas, Jb, Joshi, Pk, Josyula, N, Jung, B, Kähönen, M, Kamatani, Y, Kammerer, Cm, Kanai, M, Kastarinen, M, Kerr, Sm, Khor, Cc, Kiess, W, Kleber, Me, Koenig, W, Kooner, J, Körner, A, Kovacs, P, Kraja, At, Krajcoviechova, A, Kramer, H, Krämer, Bk, Kronenberg, F, Kubo, M, Kühnel, B, Kuokkanen, M, Kuusisto, J, La Bianca, M, Laakso, M, Lange, La, Langefeld, Cd, Lee, Jj, Lehne, B, Lehtimäki, T, Lieb, W, Lifelines Cohort, Study, Lim, Sc, Lind, L, Lindgren, Cm, Liu, J, Loeffler, M, Loos, Rjf, Lucae, S, Lukas, Ma, Lyytikäinen, Lp, Mägi, R, Magnusson, Pke, Mahajan, A, Martin, Ng, Martins, J, März, W, Mascalzoni, D, Matsuda, K, Meisinger, C, Meitinger, T, Melander, O, Metspalu, A, Mikaelsdottir, Ek, Milaneschi, Y, Miliku, K, Mishra, Pp, V. A., Million Veteran Program, Mohlke, Kl, Mononen, N, Montgomery, Gw, Mook-Kanamori, Do, Mychaleckyj, Jc, Nadkarni, Gn, Nalls, Ma, Nauck, M, Nikus, K, Ning, B, Nolte, Im, Noordam, R, O'Connell, J, O'Donoghue, Ml, Olafsson, I, Oldehinkel, Aj, Orho-Melander, M, Ouwehand, Wh, Padmanabhan, S, Palmer, Nd, Palsson, R, Penninx, Bwjh, Perls, T, Perola, M, Pirastu, M, Pirastu, N, Pistis, G, Podgornaia, Ai, Polasek, O, Ponte, B, Porteous, Dj, Poulain, T, Pramstaller, Pp, Preuss, Mh, Prins, Bp, Province, Ma, Rabelink, Tj, Raffield, Lm, Raitakari, Ot, Reilly, Df, Rettig, R, Rheinberger, M, Rice, Km, Ridker, Pm, Rivadeneira, F, Rizzi, F, Roberts, Dj, Robino, A, Rossing, P, Rudan, I, Rueedi, R, Ruggiero, D, Ryan, Ka, Saba, Y, Sabanayagam, C, Salomaa, V, Salvi, E, Saum, Ku, Schmidt, H, Schmidt, R, Schöttker, B, Schulz, Ca, Schupf, N, Shaffer, Cm, Shi, Y, Smith, Av, Smith, Bh, Soranzo, N, Spracklen, Cn, Strauch, K, Stringham, Hm, Stumvoll, M, Svensson, Po, Szymczak, S, Tai, E, Tajuddin, Sm, Tan, Nyq, Taylor, Kd, Teren, A, Tham, Yc, Thiery, J, Thio, Chl, Thomsen, H, Thorleifsson, G, Toniolo, D, Tönjes, A, Tremblay, J, Tzoulaki, I, Uitterlinden, Ag, Vaccargiu, S, van Dam, Rm, van der Harst, P, van Duijn, Cm, Velez Edward, Dr, Verweij, N, Vogelezang, S, Völker, U, Vollenweider, P, Waeber, G, Waldenberger, M, Wallentin, L, Wang, Yx, Wang, C, Waterworth, Dm, Bin Wei, W, White, H, Whitfield, Jb, Wild, Sh, Wilson, Jf, Wojczynski, Mk, Wong, C, Wong, Ty, Xu, L, Yang, Q, Yasuda, M, Yerges-Armstrong, Lm, Zhang, W, Zonderman, Ab, Rotter, Ji, Bochud, M, Psaty, Bm, Vitart, V, Wilson, Jg, Dehghan, A, Parsa, A, Chasman, Di, Ho, K, Morris, Ap, Devuyst, O, Akilesh, S, Pendergrass, Sa, Sim, X, Böger, Ca, Okada, Y, Edwards, Tl, Snieder, H, Stefansson, K, Hung, Am, Heid, Im, Scholz, M, Teumer, A, Köttgen, A, and Pattaro, C.

Subjects
catalog, Inheritance Patterns, Hasso-Plattner-Institut für Digital Engineering GmbH, Genome-wide association study, Disease, Kidney Function Tests, Bioinformatics, DISEASE, 0302 clinical medicine, Uromodulin/urine, kidney function, 11 Medical and Health Sciences, Genetics & Heredity, ddc:616, 0303 health sciences, Kidney, Genome-wide association, HERITABILITY, GENOME-WIDE ASSOCIATION, COMMON VARIANTS, RENAL-FUNCTION, TRANS-EQTLS, METAANALYSIS, TRANSPORTER, CLASSIFICATION, INTEGRATION, Chromosome Mapping, 3. Good health, Phenotype, medicine.anatomical_structure, Medical genetics, Common variants, Renal function, Trans-EQTLS, Metaanalysis, Heritability, Transporter, Life Sciences & Biomedicine, Glomerular Filtration Rate, Metaanalysi, medicine.medical_specialty, Genotype, European Continental Ancestry Group, Quantitative Trait Loci, Common variant, Quantitative trait locus, Biology, Polymorphism, Single Nucleotide, Article, White People, V. A. Million Veteran Program, 03 medical and health sciences, Quantitative Trait, Heritable, Lifelines Cohort Study, Uromodulin, Genetics, medicine, Humans, Genetic Predisposition to Disease, Renal Insufficiency, Chronic, Genetic Association Studies, 030304 developmental biology, Genetic association, Science & Technology, urogenital system, association, genetic loci, 06 Biological Sciences, medicine.disease, Renal Insufficiency, Chronic/genetics/physiopathology/urine, Genetic Association Studies/methods, ddc:000, 030217 neurology & neurosurgery, Developmental Biology, Genome-Wide Association Study, Kidney disease
Abstract

Chronic kidney disease (CKD) is responsible for a public health burden with multi-systemic complications. Through trans-ancestry meta-analysis of genome-wide association studies of estimated glomerular filtration rate (eGFR) and independent replication (n = 1,046,070), we identified 264 associated loci (166 new). Of these, 147 were likely to be relevant for kidney function on the basis of associations with the alternative kidney function marker blood urea nitrogen (n = 416,178). Pathway and enrichment analyses, including mouse models with renal phenotypes, support the kidney as the main target organ. A genetic risk score for lower eGFR was associated with clinically diagnosed CKD in 452,264 independent individuals. Colocalization analyses of associations with eGFR among 783,978 European-ancestry individuals and gene expression across 46 human tissues, including tubulo-interstitial and glomerular kidney compartments, identified 17 genes differentially expressed in kidney. Fine-mapping highlighted missense driver variants in 11 genes and kidney-specific regulatory variants. These results provide a comprehensive priority list of molecular targets for translational research.

Published
2019
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15. Prevalência e susceptibilidade antimicrobiana de sorotipos de Salmonella spp. isolados de frangos vivos e carcaças no estado do Rio de Janeiro

Author

Baptista, Daniela Q., Santos, André F.M., Aquino, Maria Helena C., Abreu, Dayse L.C., Rodrigues, Dália P., Nascimento, Elmiro R., and Pereira, Virginia L.A.

Subjects
sorotipo, frango, broilers, Salmonella spp, Rio de Janeiro, bacterioses, serotype, poultry carcass, Susceptiblidade antimicrobiana, carcaças, Antimicrobial susceptibility, Brazil
Abstract

RESUMO: A presença de Salmonella spp. em produtos de origem avícola e seus subprodutos se mostra um grande desafio para a produção comercial. Dados de prevalência, dos sorotipos circulantes e do perfil de susceptibilidade antimicrobiana de cepas de Salmonella spp. no Estado do Rio de Janeiro são escassos. Portanto, objetivou-se detectar a presença Salmonella spp. em frangos vivos e carcaças em matadouros do Estados do Rio de Janeiro, identificar os sorotipos e avaliar a susceptibilidade antimicrobiana dessas cepas para fluoroquinolonas e betalactâmicos. Foram coletadas 60 amostras cloacais de frangos vivos e 60 amostras de carcaça de seis matadouros sob Inspeção Estadual (SIE). Os isolados foram sorotipificados e testados frente a oito antimicrobianos: enrofloxacina, ciprofloxacina, norfloxacina, cefalotina, ceftiofur, cefotaxima, amoxicilina/ácido clavulânico e ampicilina pelo método de difusão em disco. Os resultados mostraram uma prevalência de Salmonella spp. de 1,66% (1/60) em amostras de suabe de cloaca e de 26,66% (16/60) em carcaças. Em amostras de suabe de cloaca, somente o sorotipo Senftenberg (1,66%) foi isolado. No total, foram isolados sete sorotipos diferentes nas carcaças: Senftenberg (15%) o mais frequente, seguido por Mbandaka (8,3%), Schwarzengrund (3,3%), Cerro (3,3%), Ohio (3,3%), Minnesota (1,66%) e Tennessee (1,66%). Em relação à susceptibilidade antimicrobiana, 29 (87,87%) isolados foram sensíveis a todos os antimicrobianos testados e 4 (12,12%) isolados foram resistentes a pelo menos três antimicrobianos betalactâmicos ou mais. Não foi observada resistência às fluoroquinolonas. Os resultados encontrados demonstram uma prevalência de Salmonella spp. acima da esperada em matadouros do Estado do Rio de Janeiro, além da presença de vários sorotipos de Salmonella spp. A resistência encontrada para betalactâmicos alerta para a disseminação dessas cepas pela cadeia alimentar. ABSTRACT: The presence of Salmonella spp. in poultry products and their by-products is a major challenge for commercial production. Data about the prevalence, the circulating serotypes and the antimicrobial susceptibility profile of Salmonella spp. strains in the State of Rio de Janeiro are scarce. Therefore, the aim of this study was to detect the presence of Salmonella spp. in live chickens and carcasses in slaughterhouses of the State of Rio de Janeiro, to identify the serotypes and to evaluate the antimicrobial susceptibility of these strains for fluoroquinolones and beta-lactams. Sixty cloacal swabs samples from broiler chickens and sixty samples of carcasses from six slaughterhouses under State Inspection were collected. The isolates were serotyped and resistance was tested to eight antimicrobials: enrofloxacin, ciprofloxacin, norfloxacin, cephalothin, ceftiofur, cefotaxime, amoxicillin/clavulanic acid and ampicillin by disc diffusion method. The results showed a prevalence of Salmonella spp. of 1.66% (1/60) in cloacal swabs samples and 26.66% (16/60) in carcasses. In cloacal swabs sample only Senftenberg (1.66%) serotype was isolated. In total, seven different serotypes were obtained from carcasses: Senftenberg (15%), followed by Mbandaka (8.3%), Schwarzengrund (3.3%), Cerro (3.3%), Ohio (3.3%), Minnesota (1.66%) and Tennessee (1.66%). Regarding antimicrobial susceptibility, 29 (87.87%) isolates were sensitive to all antimicrobials tested and 4 (12.12%) isolates were resistant to three or more beta-lactams antimicrobials. No susceptibility to fluoroquinolones was observed. These results showed a prevalence of Salmonella spp. higher than expected in slaughterhouses in the State of Rio de Janeiro, besides the presence of several serotypes of Salmonella spp. The resistance found for beta-lactams alerts to the spread of these strains through the food chain.

Published
2018

16. Situação epidemiológica da micoplasmose aviária no Estado do Rio de Janeiro

Author

Teixeira, Valéria Christina Magalhães, Baptista, Daniela de Queiroz, Carlos, Fernanda Carla, de Menezes, Willker Rocha, José, Daniela Sabroza, Barreto, Maria Lúcia, Abreu, Dayse Lima da Costa, Pereira, Virginia Léo de Almeida, and do Nascimento, Elmiro Rosendo

Subjects
avicultura, Mycoplasma synoviae, diagnosis, poultry, Veterinary medicine, SF600-1100, Mycoplasma gallisepticum, diagnóstico
Abstract

Teixeira V.C.M., Baptista D.Q., Carlos F.C., Menezes W.R., José D.S., Barreto M.L., Abreu D.L.C., Pereira V.L.A. & Nascimento E.R. [Epidemiological situation of avian mycoplamosis in the State of Rio de Janeiro, Brazil.] Situação epidemiológica da micoplasmose aviária no Estado do Rio de Janeiro. Revista Brasileira de Medicina Veterinária, 37(4):379-385, 2015. Departamento de Saúde Coletiva Veterinária e Saúde Pública, Faculdade de Medicina Veterinária, Universidade Federal Fluminense, Rua Vital Brasil, 64, Santa Rosa, Niterói, RJ 24320-340, Brasil. E-mail: petlela@hotmail.com This study was conducted to characterize the Mycoplasmosis epidemiological situation in Rio de Janeiro State. The state was divided into three regions considered significant in poultry production in the state and 252 samples of tracheal specimens were taken, using swabs dipped in 1.5ml of Frey medium and 2.5 ml of blood from 884 birds, in 47 flocks, from 11broiler chickens farms, 6 laying hens farms and 1 broiler breeders farm, of which were evaluated 334 broilers, 205 laying hens and 345 broilers breeders. The serums were subjected to Rapid Serum Agglutination (RSA) and ELISA for detection of antibodies against Mycoplasma gallisepticum (MG) and M. synoviae (MS) and the swabs used in the polymerase chain reaction (PCR) for those agents detection. Were obtained by SAR for MG and MS in the 884 birds studied, frequencies of 14.25% (126/884) and 13.68% (121/884), respectively. By ELISA, were btained 16.17% (143/884) for MG and 15.61% (138/884) for MS. According to the type of production, it was found in broilers chickens by SAR, 11.37% (38/334) for MG and 9.5% (32/334) for MS and in the ELISA, 9.28% (31/334) for MG and 9.88% (33/334) for MS. In laying chickens, the frequency of positive birds by SAR for MG and MS were in an amount of 42.92% (88/205) and 43.41% (89/205), respectively, and by ELISA, 54.63% (112/205) for MG and 49.75% (102/205) for MS. The broiler breeders shown to be negative for MG by SAR and by ELISA, but for MS, 0.86% (2/345) were positive only by ELISA. When comparing the frequencies for MG and MS in the flocks studied, by SAR, was obtained a total of positivity of 55.31% (26/47) for MG and 63.82% (30/47) for MS, and by ELISA, 51.06% (24/47) and 68.08% (32/47), respectively. For each type of production, was obtained for the broilers chickens a positivity to the SAR of 40% (10/25) for MG e 56% (14/25) for MS; and to the ELISA, 28% (7/25) e 60% (15/25) for MG and MS, respectively. In laying chickens was obtained values of 80% (16/20) for the MG and MS by SAR, whereas by ELISA, was obtained 85% (17/20) for MG and 75% (15/20) for MS. In breeders, by ELISA both two flocks studied were positive only for MS. By PCR, the total of positivity for MG and MS were in an amount of 1.19% (3/252) and 9.92% (25/252), respectively. For each type of production, were obtained 0.78% (1/127) of positive for MS in broilers chickens. In laying hens chickens, the results were 2.6% (3/115) positive for MG and 20.86% (24/115) for MS. About the broiler breeders, there was no positivity by PCR. The frequency of positives for MG and MS, by PCR, in the total of the flocks studied were, respectively, 2.12% (1/47) and 21.27% (10/47). By type of production, were not found positive flocks for MG, however, for MS was obtained 4% (1/25) in the broilers. In laying chickens, it was verifiedthat 5% (1/20) of the flocks were positive for MG and 45% (9/20) for MS. All flocks of broiler breeders were negative for MG and MS. Higher prevalence for MS were detected in the layeing hens farms than in the broilers farms and breeders farm, such as by serology as by PCR. The prevalence of MG was higher in broilers chickens than in broilers breeders. There was high positivity in laying hens, whose data was not considered because included vaccinated chickens. There were differences in the results obtained for the broilers flocks and laying hens flocks and in the positivity among the flocks, which can be attributed to differences in farm building and structures, in the ambience and manger inherent to each type of production. In this research for MG and MS in poultry production, was obtained higher frequency of positive by ELISA than by SAR, with a low agreement between the tests., Realizou-se um estudo para caracterizar a situação epidemiológica da Micoplasmose no Estado do Rio de Janeiro, o qual foi dividido em três regiões consideradas expressivas em produção avícola no Estado. Foram realizadas coletas de 252 espécimes de traqueia, utilizando suabes imersos em 1,5ml de meio de Frey e 2,5 ml de sangue de 884 aves, em 47 lotes, provenientes de 11 propriedades de criação de frangos de corte, 6 de postura e em 1 de matrizes pesadas, das quais foram avaliados 334 frangos de corte, 205 galinhas de postura e 345 matrizes pesadas. Os soros foram submetidos à Soroaglutinação rápida (SAR) e ao ELISA para detec- ção de anticorpos contra MG e MS e os suabes utilizados na reação em cadeia pela polimerase (PCR), para detecção desses agentes. Foram obtidas à SAR para Mycoplasma gallisepticum (MG) e M. synoviae (MS) nas 884 aves estudadas, frequências de 14,25% (126/884) e 13,68% (121/884), respectivamente. Ao ELISA, foram obtidos 16,17% (143/884) para MG e 15,61% (138/884) para MS. De acordo com o tipo de produção, verificou-se nos frangos de corte pela SAR 11,37% (38/334) para MG e para MS, 9,5% (32/334) e no ELISA, 9,28%(31/334) para MG e 9,88% (33/334) para MS. Em galinhas de postura, as frequências de aves positivas à SAR para MG e MS foram de 42,92% (88/205) e 43,41% (89/205), respectivamente, e ao ELISA, 54,63% (112/205) para MG e 49,75% (102/205) para MS. As matrizes pesadas apresentaram-se negativas para MG à SAR e ao ELISA, mas para MS, 0,86% (2/345) foram positivas apenas ao ELISA. Quando comparadas as frequências para MG e para MS nos lotes estudados, à SAR, obtive-se um total de positividade de 55,31% (26/47) para MG e 63,82% (30/47) para MS, e ao ELISA, 51,06% (24/47) e 68,08% (32/47), respectivamente. Por tipos de produção, obteve-se para os frangos de corte uma positividade à SAR de 40% (10/25) para MG e 56% (14/25) para MS; e ao ELISA, 28% (7/25) e 60% (15/25) para MG e MS, respectivamente. Em galinhas de postura, obteve- -se valores de 80% (16/20) para MG e MS à SAR, enquanto que ao ELISA, obteve-se 85% (17/20) para MG e 75% (15/20) para MS. Nas matrizes, ao ELISA os dois lotes estudados foram positivos apenas para MS. À PCR, os coeficientes de positividade total das aves para MG e MS foram de 1,19% (3/252) e 9,92% (25/252), respectivamente. Por tipos de produção, foram obtidos 0,78% (1/127) de positividade para MS em frangos de corte. Nas galinhas de postura, os resultados foram 2,6% (3/115) positivos para MG e 20,86% (24/115) para MS. Quanto as matrizes, não houve positividade à PCR. A frequência de positivos para MG e MS, à PCR, no total de lotes estudados foi, respectivamente, 2,12% (1/47) e 21,27% (10/47). Por tipo de produção, não foram encontrados lotes positivos para MG, entretanto para MS obteve-se 4% (1/25) nos frangos. Na postura comercial, verificou-se que 5% (1/20) dos lotes foram positivos para MG e 45%(9/20), para MS. Todos os lotes de matrizes pesadas foram negativos para MG e MS. Foi detectada maior prevalência para MS nas criações de postura que nas criações de frangos de corte e reprodução tanto pela sorologia como pela PCR. A prevalência de MG foi maior em frangos de corte que nas matrizes pesadas. Houve alta positividade em poedeiras comerciais, não sendo considerados esses dados porque incluíam galinhas vacinadas. Houve diferença nos resultados obtidos para as criações de frangos de corte e de postura comercial e na positividade entre os lotes, o que pode ser atribuído às diferenças nas instalações, na ambiência e no manejo inerentes ao tipo de produção. Na pesquisa para MG e MS nas criações avícolas, foi obtida maior frequência de positivos ao ELISA que à SAR, com uma fraca concordância entre os testes.

Published
2015

17. Target genes, variants, tissues and transcriptional pathways influencing human serum urate levels

Author

Tin, Adrienne, Marten, Jonathan, Kuhns, Victoria L. Halperin, Li, Yong, Wuttke, Matthias, Kirsten, Holger, Sieber, Karsten B., Qiu, Chengxiang, Gorski, Mathias, Yu, Zhi, Giri, Ayush, Sveinbjornsson, Gardar, Li, Man, Chu, Audrey Y., Hoppmann, Anselm, O'Connor, Luke J., Prins, Bram, Nutile, Teresa, Noce, Damia, Akiyama, Masato, Cocca, Massimiliano, Ghasemi, Sahar, van Der Most, Peter J., Horn, Katrin, Xu, Yizhe, Fuchsberger, Christian, Sedaghat, Sanaz, Afaq, Saima, Amin, Najaf, Arnlov, Johan, Bakker, Stephan J. L., Bansal, Nisha, Baptista, Daniela, Bergmann, Sven, Biggs, Mary L., Biino, Ginevra, Boerwinkle, Eric, Bottinger, Erwin P., Boutin, Thibaud S., Brumat, Marco, Burkhardt, Ralph, Campana, Eric, Campbell, Archie, Campbell, Harry, Carroll, Robert J., Catamo, Eulalia, Chambers, John C., Ciullo, Marina, Concas, Maria Pina, Coresh, Josef, Corre, Tanguy, Cusi, Daniele, Felicita, Sala Cinzia, de Borst, Martin H., De Grandi, Alessandro, de Mutsert, Rene, de Vries, Aiko P. J., Delgado, Graciela, Demirkan, Ayse, Devuyst, Olivier, Dittrich, Katalin, Eckardt, Kai-Uwe, Ehret, Georg, Endlich, Karlhans, Evans, Michele K., Gansevoort, Ron T., Gasparini, Paolo, Giedraitis, Vilmantas, Gieger, Christian, Girotto, Giorgia, Ggele, Martin, Gordon, Scott D., Gudbjartsson, Daniel F., Gudnason, Vilmundur, Haller, Toomas, Hamet, Pavel, Harris, Tamara B., Hayward, Caroline, Hicks, Andrew A., Hofer, Edith, Holm, Hilma, Huang, Wei, Hutri-Kahonen, Nina, Hwang, Shih-Jen, Ikram, M. Arfan, Lewis, Raychel M., Ingelsson, Erik, Jakobsdottir, Johanna, Jonsdottir, Ingileif, Jonsson, Helgi, Joshi, Peter K., Josyula, Navya Shilpa, Jung, Bettina, Kahonen, Mika, Kamatani, Yoichiro, Kanai, Masahiro, Kerr, Shona M., Kiess, Wieland, Kleber, Marcus E., Koenig, Wolfgang, Kooner, Jaspal S., Korner, Antje, Kovacs, Peter, Kramer, Bernhard K., Kronenberg, Florian, Kubo, Michiaki, Kuhnel, Brigitte, La Bianca, Martina, Lange, Leslie A., Lehne, Benjamin, Lehtimaki, Terho, Liu, Jun, Loeffler, Markus, Loos, Ruth J. F., Lyytikainen, Leo-Pekka, Magi, Reedik, Mahajan, Anubha, Martin, Nicholas G., Marz, Winfried, Mascalzoni, Deborah, Matsuda, Koichi, Meisinger, Christa, Meitinger, Thomas, Metspalu, Andres, Milaneschi, Yuri, ODonnell, Christopher J., Wilson, Otis D., Gaziano, J. Michael, Mishra, Pashupati P., Mohlke, Karen L., Mononen, Nina, Montgomery, Grant W., Mook-Kanamori, Dennis O., Mueller-Nurasyid, Martina, Nadkarni, Girish N., Nalls, Mike A., Nauck, Matthias, Nikus, Kjell, Ning, Boting, Nolte, Ilja M., Noordam, Raymond, O'Connell, Jeffrey R., Olafsson, Isleifur, Padmanabhan, Sandosh, Penninx, Brenda W. J. H., Perls, Thomas, Peters, Annette, Pirastu, Mario, Pirastu, Nicola, Pistis, Giorgio, Polasek, Ozren, Ponte, Belen, Porteous, David J., Poulain, Tanja, Preuss, Michael H., Rabelink, Ton J., Raffield, Laura M., Raitakari, Olli T., Rettig, Rainer, Rheinberger, Myriam, Rice, Kenneth M., Rizzi, Federica, Robino, Antonietta, Rudan, Igor, Krajcoviechova, Alena, Cifkova, Renata, Rueedi, Rico, Ruggiero, Daniela, Ryan, Kathleen A., Saba, Yasaman, Salvi, Erika, Schmidt, Helena, Schmidt, Reinhold, Shaffer, Christian M., Smith, Albert, V, Smith, Blair H., Spracklen, Cassandra N., Strauch, Konstantin, Stumvoll, Michael, Sulem, Patrick, Tajuddin, Salman M., Teren, Andrej, Thiery, Joachim, Thio, Chris H. L., Thorsteinsdottir, Unnur, Toniolo, Daniela, Tonjes, Anke, Tremblay, Johanne, Uitterlinden, Andre G., Vaccargiu, Simona, van der Harst, Pim, van Duijn, Cornelia M., Verweij, Niek, Voelker, Uwe, Vollenweider, Peter, Waeber, Gerard, Waldenberger, Melanie, Whitfield, John B., Wild, Sarah H., Wilson, James F., Yang, Qiong, Zhang, Weihua, Zonderman, Alan B., Bochud, Murielle, Wilson, James G., Pendergrass, Sarah A., Ho, Kevin, Parsa, Afshin, Pramstaller, Peter P., Psaty, Bruce M., Boeger, Carsten A., Snieder, Harold, Butterworth, Adam S., Okada, Yukinori, Edwards, Todd L., Stefansson, Kari, Susztak, Katalin, Scholz, Markus, Heid, Iris M., Hung, Adriana M., Teumer, Alexander, Pattaro, Cristian, Woodward, Owen M., Vitart, Veronique, Koettgen, Anna, Tin, Adrienne, Marten, Jonathan, Kuhns, Victoria L. Halperin, Li, Yong, Wuttke, Matthias, Kirsten, Holger, Sieber, Karsten B., Qiu, Chengxiang, Gorski, Mathias, Yu, Zhi, Giri, Ayush, Sveinbjornsson, Gardar, Li, Man, Chu, Audrey Y., Hoppmann, Anselm, O'Connor, Luke J., Prins, Bram, Nutile, Teresa, Noce, Damia, Akiyama, Masato, Cocca, Massimiliano, Ghasemi, Sahar, van Der Most, Peter J., Horn, Katrin, Xu, Yizhe, Fuchsberger, Christian, Sedaghat, Sanaz, Afaq, Saima, Amin, Najaf, Arnlov, Johan, Bakker, Stephan J. L., Bansal, Nisha, Baptista, Daniela, Bergmann, Sven, Biggs, Mary L., Biino, Ginevra, Boerwinkle, Eric, Bottinger, Erwin P., Boutin, Thibaud S., Brumat, Marco, Burkhardt, Ralph, Campana, Eric, Campbell, Archie, Campbell, Harry, Carroll, Robert J., Catamo, Eulalia, Chambers, John C., Ciullo, Marina, Concas, Maria Pina, Coresh, Josef, Corre, Tanguy, Cusi, Daniele, Felicita, Sala Cinzia, de Borst, Martin H., De Grandi, Alessandro, de Mutsert, Rene, de Vries, Aiko P. J., Delgado, Graciela, Demirkan, Ayse, Devuyst, Olivier, Dittrich, Katalin, Eckardt, Kai-Uwe, Ehret, Georg, Endlich, Karlhans, Evans, Michele K., Gansevoort, Ron T., Gasparini, Paolo, Giedraitis, Vilmantas, Gieger, Christian, Girotto, Giorgia, Ggele, Martin, Gordon, Scott D., Gudbjartsson, Daniel F., Gudnason, Vilmundur, Haller, Toomas, Hamet, Pavel, Harris, Tamara B., Hayward, Caroline, Hicks, Andrew A., Hofer, Edith, Holm, Hilma, Huang, Wei, Hutri-Kahonen, Nina, Hwang, Shih-Jen, Ikram, M. Arfan, Lewis, Raychel M., Ingelsson, Erik, Jakobsdottir, Johanna, Jonsdottir, Ingileif, Jonsson, Helgi, Joshi, Peter K., Josyula, Navya Shilpa, Jung, Bettina, Kahonen, Mika, Kamatani, Yoichiro, Kanai, Masahiro, Kerr, Shona M., Kiess, Wieland, Kleber, Marcus E., Koenig, Wolfgang, Kooner, Jaspal S., Korner, Antje, Kovacs, Peter, Kramer, Bernhard K., Kronenberg, Florian, Kubo, Michiaki, Kuhnel, Brigitte, La Bianca, Martina, Lange, Leslie A., Lehne, Benjamin, Lehtimaki, Terho, Liu, Jun, Loeffler, Markus, Loos, Ruth J. F., Lyytikainen, Leo-Pekka, Magi, Reedik, Mahajan, Anubha, Martin, Nicholas G., Marz, Winfried, Mascalzoni, Deborah, Matsuda, Koichi, Meisinger, Christa, Meitinger, Thomas, Metspalu, Andres, Milaneschi, Yuri, ODonnell, Christopher J., Wilson, Otis D., Gaziano, J. Michael, Mishra, Pashupati P., Mohlke, Karen L., Mononen, Nina, Montgomery, Grant W., Mook-Kanamori, Dennis O., Mueller-Nurasyid, Martina, Nadkarni, Girish N., Nalls, Mike A., Nauck, Matthias, Nikus, Kjell, Ning, Boting, Nolte, Ilja M., Noordam, Raymond, O'Connell, Jeffrey R., Olafsson, Isleifur, Padmanabhan, Sandosh, Penninx, Brenda W. J. H., Perls, Thomas, Peters, Annette, Pirastu, Mario, Pirastu, Nicola, Pistis, Giorgio, Polasek, Ozren, Ponte, Belen, Porteous, David J., Poulain, Tanja, Preuss, Michael H., Rabelink, Ton J., Raffield, Laura M., Raitakari, Olli T., Rettig, Rainer, Rheinberger, Myriam, Rice, Kenneth M., Rizzi, Federica, Robino, Antonietta, Rudan, Igor, Krajcoviechova, Alena, Cifkova, Renata, Rueedi, Rico, Ruggiero, Daniela, Ryan, Kathleen A., Saba, Yasaman, Salvi, Erika, Schmidt, Helena, Schmidt, Reinhold, Shaffer, Christian M., Smith, Albert, V, Smith, Blair H., Spracklen, Cassandra N., Strauch, Konstantin, Stumvoll, Michael, Sulem, Patrick, Tajuddin, Salman M., Teren, Andrej, Thiery, Joachim, Thio, Chris H. L., Thorsteinsdottir, Unnur, Toniolo, Daniela, Tonjes, Anke, Tremblay, Johanne, Uitterlinden, Andre G., Vaccargiu, Simona, van der Harst, Pim, van Duijn, Cornelia M., Verweij, Niek, Voelker, Uwe, Vollenweider, Peter, Waeber, Gerard, Waldenberger, Melanie, Whitfield, John B., Wild, Sarah H., Wilson, James F., Yang, Qiong, Zhang, Weihua, Zonderman, Alan B., Bochud, Murielle, Wilson, James G., Pendergrass, Sarah A., Ho, Kevin, Parsa, Afshin, Pramstaller, Peter P., Psaty, Bruce M., Boeger, Carsten A., Snieder, Harold, Butterworth, Adam S., Okada, Yukinori, Edwards, Todd L., Stefansson, Kari, Susztak, Katalin, Scholz, Markus, Heid, Iris M., Hung, Adriana M., Teumer, Alexander, Pattaro, Cristian, Woodward, Owen M., Vitart, Veronique, and Koettgen, Anna

Abstract

Elevated serum urate levels cause gout and correlate with cardiometabolic diseases via poorly understood mechanisms. We performed a trans-ancestry genome-wide association study of serum urate in 457,690 individuals, identifying 183 loci (147 previously unknown) that improve the prediction of gout in an independent cohort of 334,880 individuals. Serum urate showed significant genetic correlations with many cardiometabolic traits, with genetic causality analyses supporting a substantial role for pleiotropy. Enrichment analysis, fine-mapping of urate-associated loci and colocalization with gene expression in 47 tissues implicated the kidney and liver as the main target organs and prioritized potentially causal genes and variants, including the transcriptional master regulators in the liver and kidney, HNF1A and HNF4A. Experimental validation showed that HNF4A transactivated the promoter of ABCG2, encoding a major urate transporter, in kidney cells, and that HNF4A p.Thr139Ile is a functional variant. Transcriptional coregulation within and across organs may be a general mechanism underlying the observed pleiotropy between urate and cardiometabolic traits.

Published
2019
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18. Follicular regulatory helper T cells control the response of regulatory B cells to a high-cholesterol diet.

Author

Burger, Fabienne, Miteva, Kapka, Baptista, Daniela, Roth, Aline, Fraga-Silva, Rodrigo A, Martel, Catherine, Stergiopulos, Nikolaos, Mach, François, and Brandt, Karim J

Subjects
T helper cells, SUPPRESSOR cells, REGULATORY B cells, HIGH cholesterol diet, CELL populations
Abstract

Aims B cell functions in the process of atherogenesis have been investigated but several aspects remain to be clarified. Methods and results In this study, we show that follicular regulatory helper T cells (TFR) control regulatory B cell (BREG) populations in Apoe−/− mice models on a high-cholesterol diet (HCD). Feeding mice with HCD resulted in up-regulation of TFR and BREG cell populations, causing the suppression of proatherogenic follicular helper T cell (TFH) response. TFH cell modulation is correlated with the growth of atherosclerotic plaque size in thoracoabdominal aortas and aortic root plaques, suggesting that TFR cells are atheroprotective. During adoptive transfer experiments, TFR cells transferred into HCD mice decreased TFH cell populations, atherosclerotic plaque size, while BREG cell population and lymphangiogenesis are significantly increased. Conclusion Our results demonstrate that, through different strategies, both TFR and TFH cells modulate anti- and pro-atherosclerotic immune processes in an Apoe−/− mice model since TFR cells are able to regulate both TFH and BREG cell populations as well as lymphangiogenesis and lipoprotein metabolism. [ABSTRACT FROM AUTHOR]

Published
2021
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19. Follicular regulatory T cell in atherosclerosis

Author

Baptista, Daniela, Mach, François, and Brandt, Karim

Subjects
ddc:616, Atherosclerosis/immunology/pathology, Regulatory/immunology/pathology, T-Lymphocytes, Animals, Humans
Abstract

Atherosclerosis is a chronic inflammatory disease involving the infiltration of immune cells, such as monocytes/macrophages, neutrophils, T cells, and B cells, into the inner layer of vessel walls. T and B cell functions in the process of atherogenesis, as well as their mutual regulation, have been investigated but several aspects remain to be clarified. In the present review, we give a brief overview of the functions of follicular regulatory T cell (Tfr) on follicular T (Tfh) and B cell regulation related to atherosclerosis pathogenesis, including their influence on lymphangiogenesis and lipoprotein metabolism. We will also discuss their potential therapeutics properties in the resolution of established atherosclerotic lesions.

Published
2018

21. Genome-Wide Meta-Analysis Unravels Interactions between Magnesium Homeostasis and Metabolic Phenotypes

Author

Corre, Tanguy, primary, Arjona, Francisco J., additional, Hayward, Caroline, additional, Youhanna, Sonia, additional, de Baaij, Jeroen H.F., additional, Belge, Hendrica, additional, Nägele, Nadine, additional, Debaix, Huguette, additional, Blanchard, Maxime G., additional, Traglia, Michela, additional, Harris, Sarah E., additional, Ulivi, Sheila, additional, Rueedi, Rico, additional, Lamparter, David, additional, Macé, Aurélien, additional, Sala, Cinzia, additional, Lenarduzzi, Stefania, additional, Ponte, Belen, additional, Pruijm, Menno, additional, Ackermann, Daniel, additional, Ehret, Georg, additional, Baptista, Daniela, additional, Polasek, Ozren, additional, Rudan, Igor, additional, Hurd, Toby W., additional, Hastie, Nicholas D., additional, Vitart, Veronique, additional, Waeber, Geràrd, additional, Kutalik, Zoltán, additional, Bergmann, Sven, additional, Vargas-Poussou, Rosa, additional, Konrad, Martin, additional, Gasparini, Paolo, additional, Deary, Ian J., additional, Starr, John M., additional, Toniolo, Daniela, additional, Vollenweider, Peter, additional, Hoenderop, Joost G.J., additional, Bindels, René J.M., additional, Bochud, Murielle, additional, and Devuyst, Olivier, additional

Published
2017
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22. Genome-Wide Meta-Analysis Unravels Interactions between Magnesium Homeostasis and Metabolic Phenotypes

Author

UCL - SSS/IREC/NEFR - Pôle de Néphrologie, Corre, Tanguy, Arjona, Francisco J., Hayward, Caroline, Youhanna, Sonia, de Baaij, Jeroen H.F., Belge, Hendrica, Nägele, Nadine, Debaix, Huguette, Blanchard, Maxime G., Traglia, Michela, Harris, Sarah E., Ulivi, Sheila, Rueedi, Rico, Lamparter, David, Macé, Aurélien, Sala, Cinzia, Lenarduzzi, Stefania, Ponte, Belen, Pruijm, Menno, Ackermann, Daniel, Ehret, Georg, Baptista, Daniela, Polasek, Ozren, Rudan, Igor, Hurd, Toby W., Hastie, Nicholas D., Vitart, Veronique, Waeber, Geràrd, Kutalik, Zoltán, Bergmann, Sven, Vargas-Poussou, Rosa, Konrad, Martin, Gasparini, Paolo, Deary, Ian J., Starr, John M., Toniolo, Daniela, Vollenweider, Peter, Hoenderop, Joost G.J., Bindels, René J.M., Bochud, Murielle, Devuyst, Olivier, UCL - SSS/IREC/NEFR - Pôle de Néphrologie, Corre, Tanguy, Arjona, Francisco J., Hayward, Caroline, Youhanna, Sonia, de Baaij, Jeroen H.F., Belge, Hendrica, Nägele, Nadine, Debaix, Huguette, Blanchard, Maxime G., Traglia, Michela, Harris, Sarah E., Ulivi, Sheila, Rueedi, Rico, Lamparter, David, Macé, Aurélien, Sala, Cinzia, Lenarduzzi, Stefania, Ponte, Belen, Pruijm, Menno, Ackermann, Daniel, Ehret, Georg, Baptista, Daniela, Polasek, Ozren, Rudan, Igor, Hurd, Toby W., Hastie, Nicholas D., Vitart, Veronique, Waeber, Geràrd, Kutalik, Zoltán, Bergmann, Sven, Vargas-Poussou, Rosa, Konrad, Martin, Gasparini, Paolo, Deary, Ian J., Starr, John M., Toniolo, Daniela, Vollenweider, Peter, Hoenderop, Joost G.J., Bindels, René J.M., Bochud, Murielle, and Devuyst, Olivier

Abstract

Magnesium (Mg2+) homeostasis is critical for metabolism. However, the genetic determinants of the renal handling of Mg2+, which is crucial for Mg2+ homeostasis, and the potential influence on metabolic traits in the general population are unknown. We obtained plasma and urine parameters from 9099 individuals from seven cohorts, and conducted a genome-wide meta-analysis of Mg2+ homeostasis. We identified two loci associated with urinary magnesium (uMg), rs3824347 (P=4.4×10-13) near TRPM6, which encodes an epithelial Mg2+ channel, and rs35929 (P=2.1×10-11), a variant of ARL15, which encodes a GTP-binding protein. Together, these loci account for 2.3% of the variation in 24-hour uMg excretion. In human kidney cells, ARL15 regulated TRPM6-mediated currents. In zebrafish, dietary Mg2+ regulated the expression of the highly conserved ARL15 ortholog arl15b, and arl15b knockdown resulted in renal Mg2+ wasting and metabolic disturbances. Finally, ARL15 rs35929 modified the association of uMg with fasting insulin and fat mass in a general population. In conclusion, this combined observational and experimental approach uncovered a gene-environment interaction linking Mg2+ deficiency to insulin resistance and obesity.

Published
2017

23. Temporal series analyses in equine infectious anemia cases in the State of Rio de Janeiro, Brazil, 2007 to 2011.

Author

Baptista, Daniela de Queiroz, Bruhn, Fábio Raphael Pascoti, da Rocha, Christiane Maria Barcellos Magalhães, Torres, Fernanda Coelho, Machado, Everardo Duarte, Sáfadi, Thelma, Pereira, Stela Márcia, Baptista, Daniela de Queiroz, Bruhn, Fábio Raphael Pascoti, da Rocha, Christiane Maria Barcellos Magalhães, Torres, Fernanda Coelho, Machado, Everardo Duarte, Sáfadi, Thelma, and Pereira, Stela Márcia

Abstract

Baptista D.Q., Bruhn F.R.P., da Rocha C.M.B.M., Torres F.C., Machado E.D., Sáfadi T. & Pereira S.M. Temporal series analyses in equine infectious anemia cases in the State of Rio de Janeiro, Brazil, 2007 to 2011. [Análise de series temporais dos casos de anemia infecciosa equina no estado do Rio de Janeiro, Brasil, 2007 a 2011.] Revista Brasileira de Medicina Veterinária, 38(4):431- 438, 2016. Coordenadoria de Defesa Sanitária Animal, Secretaria de Estado de agricultura, Pecuária, Pesca e Abastecimento, Alameda São Boaventura, n° 770, Fonseca, Niterói, RJ 24120-191. E-mail: daniqb@yahoo.com Equine Infectious Anemia (EIA) is a disease caused by a cosmopolitan infection of which the etiological agent is the Lentivirus, which reaches equines in general. This paper presents the results of a survey of the EIA in the State of Rio de Janeiro, Brazil, by means of a temporal series from 2007 to 2011. In addition, was estimating a model of case occurrences in subsequent years. The occurrence of EIA in the State is low (0.43%), with the highest occurrence being in 2007 (0.63%). The Livestock Defense Regionals (LDRs) that had the highest prevalence of this disease were Rio de Janeiro, Niterói, Cordeiro and Tres Rios, however, the LDRs, such as Barra Mansa, Itaocara and Campos dos Goytacazes had the lowest number of tests performed, thus presenting the lowest prevalence values. This disease is still considered endemic in the state of Rio de Janeiro. The prevision analysis indicates an approximate prediction (p<0.01) of the real observation of the number of EIA cases in the State of Rio de Janeiro in the year of 2011, thus constituting an important tool for planning the control and eradication of EIA., Anemia Infecciosa Equina (AIE) é uma doença causada por infecção cosmopolita cujo agente etiológico é um Lentivirus que atinge os equídeos em geral. Esse trabalho tem como objetivos fazer um levantamento da AIE no Estado do Rio de Janeiro por meio de uma série temporal de 2007 a 2011, alem de estimar um modelo para ocorrência dos casos em anos subsequentes, fornecendo informações aos profissionais da área, para que medidas sanitárias mais eficazes possam ser adotadas no controle e erradicação. A ocorrência da AIE no Estado é baixa (0,43%), sendo a maior (0,63%) no ano de 2007. As Regionais que apresentaram maior prevalência da doença foram Rio de Janeiro, Niterói, Cordeiro e Três Rios. As Regionais de Barra Mansa, Itaocara e Campos dos Goytacazes, obtiveram o menor número de exames realizados, assim como apresentaram os menores valores de prevalência da doença. A enfermidade é endêmica no Estado do Rio de Janeiro. A análise de previsão indica uma predição aproximada (p<0,01) da observação real no numero de casos de AIE no Rio de Janeiro no ano de 2011, constituindo assim uma importante ferramenta para o planejamento de ações de controle e erradicação da AIE no estado.

Published
2016

24. The coincident activation of lemniscal and paralemniscal inputs can drive synaptic plasticity in layer 2/3 pyramidal neurons of the mouse somatosensory cortex in vivo

Author

Gambino Frédéric, Holtmaat Anthony, Pagès Stéphane, Kehayas Vassilis, Baptista Daniela, Interdisciplinary Institute for Neuroscience [Bordeaux] (IINS), and Université de Bordeaux (UB)-Centre National de la Recherche Scientifique (CNRS)

Subjects
POm, animal structures, lemniscal, Cognitive Neuroscience, Cortical Circuits, Neuroscience (miscellaneous), Neurophysiology, Somatosensory system, Time-Lapse Imaging, Optogenetic stimulation, AAV vectors, lcsh:RC321-571, photostimulation, 03 medical and health sciences, Cellular and Molecular Neuroscience, 0302 clinical medicine, Developmental Neuroscience, In vivo, Coincident, whisker stimulation, channelrhodopsin-2, lcsh:Neurosciences. Biological psychiatry. Neuropsychiatry, ComputingMilieux_MISCELLANEOUS, 030304 developmental biology, 0303 health sciences, functional plasticity, Chemistry, Somatosensory Cortex, structural plasticity, in vivo, nervous system, Synaptic plasticity, barrel cortex, [SDV.NEU]Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC], paralemniscal, LTP, two-photon imaging, Neuroscience, Layer (electronics), 030217 neurology & neurosurgery
Abstract

Structural plasticity in the somatosensory cortex is maintained throughout life. In adult animals structural changes occur at the level of dendritic spines and axonal boutons in response to alterations in sensory experience. The causal relationship between synaptic activity and structural changes, however, is not clear. Hebbian-plasticity models predict that synapses will be stabilized at the nodes of neuronal networks that display high levels of coincident activity. Here, we aim at studying the effects of a targeted increase in coincident activity between segregated inputs on pyramidal cell synapses of the mouse somatosensory barrel cortex in vivo. Supragranular layers of the barrel cortex receive anatomically distinct inputs from two thalamic pathways: the ‘lemniscal’ pathway that originates in the ventral posteromedial (VPM) nucleus and projects in a whisker-specific fashion to the barrel columns, and the ‘paralemniscal’ pathway that originates in the posteromedial (POm) nucleus and projects to the cortex in a non-specific manner. Previous work from our lab shows that rhythmic (8Hz) whisker stimulation-evoked LTP (RWS-LTP) in layer (L) 2/3 pyramidal cells relies on the combined activity of lemniscal and paralemniscal pathways. Here, we targeted ChR2 expression to POm neurons using AAV-mediated gene transfer in order to optically control the activity of those inputs. As a first step, we show that photostimulation of the POm nucleus induces NMDA-dependent, sub-threshold responses in L2/3 pyramidal cells similar to those that are required for the induction of RWS-LTP. In addition, simultaneous photostimulation of POm neurons together with whisker stimulation at low frequencies (1Hz) can also elicit LTP, suggesting that coincident lemniscal and paralemniscal input can drive LTP induction. Next, we combined the ChR2-tdTomato expression in POm neurons with sparse AAV-mediated eGFP expression in L2/3 pyramidal cells in order to study the effects of coincident activity on dendritic spines. Preliminary data suggest that simultaneous photostimulation of the POm nucleus together with whisker stimulation may also affect spine dynamics. Taken together, these results indicate that the coincident activity of the convergent lemniscal and paralemniscal inputs onto L2/3 pyramidal cells may potentiate synapses and affect their stability.

Published
2014
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25. Identidade portuguesa no mobiliário,do gótico ao design contemporâneo

Author

Baptista, Daniela

Subjects
Identidade, Artesanato, Mercado, Indústria, Mobiliário
Abstract

O presente relatório, tem por finalidade descrever os aspectos relativos a uma experiência de estágio académico onde se colocou o enfoque fundamental numa reflexão acerca de uma condição portuguesa no design, indústria, artesanato e mercado. Foi efectuado na Menina Design Group, no Porto, em que os inovadores e esclarecidos processos de investigação, análise, argumentação e criação se revelaram especialmente eficientes na configuração de produtos “globais”, contemporâneos, com evidente sucesso nos mais diversos mercados, sublinhando e enfatizando os recursos técnicos e tecnológicos existentes. Partindo da identidade portuguesa no mobiliário, dos processos de globalização e do mercado internacional, desenvolveram-se duas abordagens projectuais que pretendem interpretar o discurso de cada marca, seus valores e conteúdo narrativo e formal, destinados a “target’s” bem definidos, em mercado global, sem que com isso se deixasse de introduzir força identitária, a qualidade original e preponderantemente retórica aos artefactos de tradição portuguesa. O objectivo seria contribuir para a produção e disseminação de conhecimento sobre as relações existentes entre artesanato e design no mobiliário, para servir de suporte ao desenvolvimento projectual na MDG e testar os variados recursos disponíveis para descrever e analisar a implementação de soluções experimentalistas nas variadas áreas de intervenção da instituição.

Published
2013

27. Epidemiological situation of avian mycoplamosis in the State of Rio de Janeiro, Brazil

Author

Teixeira, Valéria Christina Magalhães, Baptista, Daniela de Queiroz, Carlos, Fernanda Carla, de Menezes, Willker Rocha, José, Daniela Sabroza, Barreto, Maria Lúcia, Abreu, Dayse Lima da Costa, Pereira, Virginia Léo de Almeida, do Nascimento, Elmiro Rosendo, Teixeira, Valéria Christina Magalhães, Baptista, Daniela de Queiroz, Carlos, Fernanda Carla, de Menezes, Willker Rocha, José, Daniela Sabroza, Barreto, Maria Lúcia, Abreu, Dayse Lima da Costa, Pereira, Virginia Léo de Almeida, and do Nascimento, Elmiro Rosendo

Abstract

Teixeira V.C.M., Baptista D.Q., Carlos F.C., Menezes W.R., José D.S., Barreto M.L., Abreu D.L.C., Pereira V.L.A. & Nascimento E.R. [Epidemiological situation of avian mycoplamosis in the State of Rio de Janeiro, Brazil.] Situação epidemiológica da micoplasmose aviária no Estado do Rio de Janeiro. Revista Brasileira de Medicina Veterinária, 37(4):379-385, 2015. Departamento de Saúde Coletiva Veterinária e Saúde Pública, Faculdade de Medicina Veterinária, Universidade Federal Fluminense, Rua Vital Brasil, 64, Santa Rosa, Niterói, RJ 24320-340, Brasil. E-mail: petlela@hotmail.com This study was conducted to characterize the Mycoplasmosis epidemiological situation in Rio de Janeiro State. The state was divided into three regions considered  significant in poultry production in the state and 252 samples of tracheal specimens were taken, using swabs dipped in 1.5ml of Frey medium and 2.5 ml of blood from 884 birds, in 47 flocks, from 11broiler chickens farms, 6 laying hens farms and 1 broiler breeders farm, of which were evaluated 334 broilers, 205 laying hens and 345 broilers breeders. The serums were subjected to Rapid Serum Agglutination  (RSA) and ELISA for detection of antibodies against Mycoplasma gallisepticum (MG) and M. synoviae (MS) and the swabs used in the polymerase chain reaction (PCR) for those agents detection. Were obtained by SAR for MG and MS in the 884 birds studied, frequencies of 14.25% (126/884) and 13.68% (121/884), respectively. By ELISA, were btained 16.17% (143/884) for MG and 15.61% (138/884) for MS. According to the type of production, it was found in broilers chickens by SAR, 11.37% (38/334) for MG and 9.5% (32/334) for MS and in the ELISA, 9.28% (31/334) for MG and 9.88% (33/334) for MS. In laying chickens, the frequency of positive birds by SAR for MG and MS were in an amount of 42.92% (88/205) and 43.41% (89/205), respectively, and by ELISA, 54.63% (112/205) for MG and 49.75% (102/205) for MS. The broiler breeders s, Realizou-se um estudo para caracterizar a situação epidemiológica da Micoplasmose no Estado do Rio de Janeiro, o qual foi dividido em três regiões consideradas expressivas em produção avícola no Estado. Foram realizadas coletas de 252 espécimes de traqueia, utilizando suabes imersos em 1,5ml de meio de Frey e 2,5 ml de sangue de 884 aves, em 47 lotes, provenientes de 11 propriedades de criação de frangos de corte, 6 de postura e em 1 de matrizes pesadas, das quais foram avaliados 334 frangos de corte, 205 galinhas de postura e 345 matrizes pesadas. Os soros foram submetidos à Soroaglutinação rápida (SAR) e ao ELISA para detec- ção de anticorpos contra MG e MS e os suabes utilizados na reação em cadeia pela polimerase (PCR), para detecção desses agentes. Foram obtidas à SAR para Mycoplasma gallisepticum (MG) e M. synoviae (MS) nas 884 aves estudadas, frequências de 14,25% (126/884) e 13,68% (121/884), respectivamente. Ao ELISA, foram obtidos 16,17% (143/884) para MG e 15,61% (138/884) para MS. De acordo com o tipo de produção, verificou-se nos frangos de corte pela SAR 11,37% (38/334) para MG e para MS, 9,5% (32/334) e no ELISA, 9,28%(31/334) para MG e 9,88% (33/334) para MS. Em galinhas de postura, as frequências de aves positivas à SAR para MG e MS foram de 42,92% (88/205) e 43,41% (89/205), respectivamente, e ao ELISA, 54,63% (112/205) para MG e 49,75% (102/205) para MS. As matrizes pesadas apresentaram-se negativas para MG à SAR e ao ELISA, mas para MS, 0,86% (2/345) foram positivas apenas ao ELISA. Quando comparadas as frequências para MG e para MS nos lotes estudados, à SAR, obtive-se um total de positividade de 55,31% (26/47) para MG e 63,82% (30/47) para MS, e ao ELISA, 51,06% (24/47) e 68,08% (32/47), respectivamente. Por tipos de produção, obteve-se para os frangos de corte uma positividade à SAR de 40% (10/25) para MG e 56% (14/25) para MS; e ao ELISA, 28% (7/25) e 60% (15/25) para MG e MS, respectivamente. Em galinhas de postura, obteve- -se valores de 80

Published
2015

28. O princípio da tipicidade e os valores mobiliários

Author

Baptista, Daniela and Veritati - Repositório Institucional da Universidade Católica Portuguesa

Abstract

Submitted by Ana Costa (apcosta@porto.ucp.pt) on 2015-03-11T17:05:52Z No. of bitstreams: 1 O Princípio da tipicidade e os valores mobiliários.pdf: 3221771 bytes, checksum: 41eb6b0710c8c909a7a2aed1d3f8afa0 (MD5) Made available in DSpace on 2015-03-12T12:22:27Z (GMT). No. of bitstreams: 1 O Princípio da tipicidade e os valores mobiliários.pdf: 3221771 bytes, checksum: 41eb6b0710c8c909a7a2aed1d3f8afa0 (MD5) Previous issue date: 2014

Published
2007

29. NLRP3 Inflammasome Activation Controls Vascular Smooth Muscle Cells Phenotypic Switch in Atherosclerosis.

Author

Burger, Fabienne, Baptista, Daniela, Roth, Aline, da Silva, Rafaela Fernandes, Montecucco, Fabrizio, Mach, François, Brandt, Karim J., and Miteva, Kapka

Subjects
*VASCULAR smooth muscle, *NLRP3 protein, *MUSCLE cells, *INFLAMMASOMES, *HIGH cholesterol diet
Abstract

(1) Background: Monocytes and nucleotide-binding oligomerization domain-like receptor protein 3 (NLRP3) inflammasome orchestrate lipid-driven amplification of vascular inflammation promoting the disruption of the fibrous cap. The components of the NLRP3 inflammasome are expressed in macrophages and foam cells within human carotid atherosclerotic plaques and VSMCs in hypertension. Whether monocytes and NLRP3 inflammasome activation are direct triggers of VSMC phenotypic switch and plaque disruption need to be investigated. (2) Methods: The direct effect of oxLDL-activated monocytes in VSMCs co-cultured system was demonstrated via flow cytometry, qPCR, ELISA, caspase 1, and pyroptosis assay. Aortic roots of VSMCs lineage tracing mice fed normal or high cholesterol diet and human atherosclerotic plaques were used for immunofluorescence quantification of NLRP3 inflammasome activation/VSMCs phenotypic switch. (3) Results: OxLDL-activated monocytes reduced α-SMA, SM22α, Oct-4, and upregulation of KLF-4 and macrophage markers MAC2, F4/80 and CD68 expression as well as caspase 1 activation, IL-1β secretion, and pyroptosis in VSMCs. Increased caspase 1 and IL-1β in phenotypically modified VSMCs was detected in the aortic roots of VSMCs lineage tracing mice fed high cholesterol diet and in human atherosclerotic plaques from carotid artery disease patients who experienced a stroke. (4) Conclusions: Taken together, these results provide evidence that monocyte promote VSMC phenotypic switch through VSMC NLRP3 inflammasome activation with a likely detrimental role in atherosclerotic plaque stability in human atherosclerosis. [ABSTRACT FROM AUTHOR]

Published
2022
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30. Ações preferenciais sem voto (em particular, as detidas por investidores qualificados)

Author

Baptista, Daniela and Veritati - Repositório Institucional da Universidade Católica Portuguesa

Abstract

Submitted by Ana Costa (apcosta@porto.ucp.pt) on 2017-01-09T18:51:28Z No. of bitstreams: 1 Ações preferenciais sem voto.PDF: 574459 bytes, checksum: 4fb9ab72e40139bec0356c1ce5e1813b (MD5) Made available in DSpace on 2017-01-23T11:19:50Z (GMT). No. of bitstreams: 1 Ações preferenciais sem voto.PDF: 574459 bytes, checksum: 4fb9ab72e40139bec0356c1ce5e1813b (MD5) Previous issue date: 2016 info:eu-repo/semantics/publishedVersion

31. A problemática dos stock buybacks e a remuneração dos administradores

Author

Gonçalves, João André dos Santos and Baptista, Daniela Farto

Subjects
Executives, Remuneration, Stock buybacks, Remuneração, Acionistas, Administradores, Ciências Sociais::Direito [Domínio/Área Científica], Shareholders
Abstract

Submitted by Ana Costa (apcosta@porto.ucp.pt) on 2021-05-19T14:30:58Z No. of bitstreams: 1 00645_02_joao-andre-goncalves-344918011-dissertacao-integral.pdf: 597947 bytes, checksum: ee159106ce3132e250ee4acfd07212ee (MD5) Approved for entry into archive by Maria Helena Ribeiro (helena.ribeiro@lisboa.ucp.pt) on 2021-06-16T15:06:43Z (GMT) No. of bitstreams: 1 00645_02_joao-andre-goncalves-344918011-dissertacao-integral.pdf: 597947 bytes, checksum: ee159106ce3132e250ee4acfd07212ee (MD5) Made available in DSpace on 2021-06-16T15:06:43Z (GMT). No. of bitstreams: 1 00645_02_joao-andre-goncalves-344918011-dissertacao-integral.pdf: 597947 bytes, checksum: ee159106ce3132e250ee4acfd07212ee (MD5) Previous issue date: 2020-09-11

Published
2020

32. O problema de agência nas entidades bancárias : o exemplo das políticas de remuneração dos administradores como mecanismo adequado a resolver conflitos de interesse

Author

Faria, Patrícia Pereira and Baptista, Daniela Furto

Subjects
Bancos, Commercial companies, Banks, Agency, Agência, Exchange, Ciências Sociais::Direito [Domínio/Área Científica], Câmbio, Globalização, Globalization, Sociedades comerciais
Abstract

Submitted by Ana Costa (apcosta@porto.ucp.pt) on 2021-05-20T15:52:46Z No. of bitstreams: 1 00768_02_patricia-pereira-faria-344918007-dissertação-integral.pdf: 705830 bytes, checksum: ba037e1555fed5df78736f2c658c1e6b (MD5) Approved for entry into archive by Maria Helena Ribeiro (helena.ribeiro@lisboa.ucp.pt) on 2021-06-17T09:46:21Z (GMT) No. of bitstreams: 1 00768_02_patricia-pereira-faria-344918007-dissertação-integral.pdf: 705830 bytes, checksum: ba037e1555fed5df78736f2c658c1e6b (MD5) Made available in DSpace on 2021-06-17T09:46:21Z (GMT). No. of bitstreams: 1 00768_02_patricia-pereira-faria-344918007-dissertação-integral.pdf: 705830 bytes, checksum: ba037e1555fed5df78736f2c658c1e6b (MD5) Previous issue date: 2020-09-11

Published
2020

33. Pessoas coletivas no órgão de administração : especificidades : (des)vantagens da sua designação no modelo clássico de governação das sociedades anónimas

Author

Brandão, João Marcelo Gomes and Baptista, Daniela

Subjects
Vantagens, Appointment, Pessoas coletivas, Legal persons, Designação, Sociedades anónimas, Disadvantages, Public limited companies, Board of directors, Desvantagens, Pessoas singulares, Advantages, Ciências Sociais::Direito [Domínio/Área Científica], Natural persons, Órgão de administração
Abstract

Submitted by Ana Costa (apcosta@porto.ucp.pt) on 2021-05-19T16:14:13Z No. of bitstreams: 1 00225_02_joao-marcelo-brandao-344918012-dissertacao-integral.pdf: 678795 bytes, checksum: 31f0762923246b14521ed08dc2620846 (MD5) Approved for entry into archive by Maria Helena Ribeiro (helena.ribeiro@lisboa.ucp.pt) on 2021-06-16T15:57:08Z (GMT) No. of bitstreams: 1 00225_02_joao-marcelo-brandao-344918012-dissertacao-integral.pdf: 678795 bytes, checksum: 31f0762923246b14521ed08dc2620846 (MD5) Made available in DSpace on 2021-06-16T15:57:08Z (GMT). No. of bitstreams: 1 00225_02_joao-marcelo-brandao-344918012-dissertacao-integral.pdf: 678795 bytes, checksum: 31f0762923246b14521ed08dc2620846 (MD5) Previous issue date: 2020-10-09

Published
2020

34. Corporate Governance : o conselho de administração e o mercado para o controlo das sociedades : que perspetivas?

Author

Sousa, Vasco Nogueira Lemos de and Baptista, Daniela Farto

Subjects
Mercado para o controlo das sociedades, Corporate Governance, Remuneração dos administradores, Governo das sociedades, Market for corporate control, Ciências Sociais::Direito [Domínio/Área Científica], Board of directors compensation
Abstract

Submitted by Cristina Afonso (cac@lisboa.ucp.pt) on 2018-12-19T14:18:10Z No. of bitstreams: 1 TESE-VASCOLEMOS.pdf: 1125412 bytes, checksum: 65f35e533a2e521962a493e1e84168c1 (MD5) Approved for entry into archive by Cristina Afonso (cac@lisboa.ucp.pt) on 2018-12-19T14:18:25Z (GMT) No. of bitstreams: 1 TESE-VASCOLEMOS.pdf: 1125412 bytes, checksum: 65f35e533a2e521962a493e1e84168c1 (MD5) Made available in DSpace on 2018-12-19T14:18:25Z (GMT). No. of bitstreams: 1 TESE-VASCOLEMOS.pdf: 1125412 bytes, checksum: 65f35e533a2e521962a493e1e84168c1 (MD5) Previous issue date: 2018-12-30

Published
2018

35. A personalidade jurídica das sociedades comerciais : em particular do reconhecimento de direitos de personalidade

Author

Barros, Sofia Pereira and Baptista, Daniela Farto

Subjects
Direitos de personalidade, Protection of legal personality, Meios de proteção, Personality rights, Human rights, Ciências Sociais::Direito [Domínio/Área Científica], Companies, Sociedades comerciais, Direitos humanos, Personalidade jurídica, Legal personality
Abstract

Submitted by Cristina Afonso (cac@lisboa.ucp.pt) on 2018-12-19T09:41:59Z No. of bitstreams: 1 Sofia Pereira Barros 340112099.pdf: 917049 bytes, checksum: e9ecb5c2a62db46dd1f5fe0c0885ea40 (MD5) Approved for entry into archive by Cristina Afonso (cac@lisboa.ucp.pt) on 2018-12-19T09:42:10Z (GMT) No. of bitstreams: 1 Sofia Pereira Barros 340112099.pdf: 917049 bytes, checksum: e9ecb5c2a62db46dd1f5fe0c0885ea40 (MD5) Made available in DSpace on 2018-12-19T09:42:10Z (GMT). No. of bitstreams: 1 Sofia Pereira Barros 340112099.pdf: 917049 bytes, checksum: e9ecb5c2a62db46dd1f5fe0c0885ea40 (MD5) Previous issue date: 2018-10-30

Published
2018

36. Direito de exoneração vs alienação potestativa : no CSC e no CVM vs OPA obrigatória : diferentes regimes para o mesmo direito de saída?

Author

Mota, Rita Isabel das Neves and Baptista, Daniela Farto

Subjects
Minority shareholders, Sócios minoritários, Potestative alienation, Company exit rights, Resignation right, OPA obrigatória, Ciências Sociais::Direito [Domínio/Área Científica], Alienação potestativa, Compulsory takeover bid (OPA), Direito de exoneração, Direitos de saída da sociedade
Abstract

Submitted by Cristina Afonso (cac@lisboa.ucp.pt) on 2018-12-18T10:05:11Z No. of bitstreams: 1 Rita Mota - 340120023.pdf: 558941 bytes, checksum: 3a516ee6e20e4a419df9b70d34559b6d (MD5) Approved for entry into archive by Cristina Afonso (cac@lisboa.ucp.pt) on 2018-12-18T10:05:26Z (GMT) No. of bitstreams: 1 Rita Mota - 340120023.pdf: 558941 bytes, checksum: 3a516ee6e20e4a419df9b70d34559b6d (MD5) Made available in DSpace on 2018-12-18T10:05:26Z (GMT). No. of bitstreams: 1 Rita Mota - 340120023.pdf: 558941 bytes, checksum: 3a516ee6e20e4a419df9b70d34559b6d (MD5) Previous issue date: 2018-10-16

Published
2018

37. O voto por correspondência : análise do seu regime jurídico

Author

Branquinho, Natacha Sofia Ventura and Baptista, Daniela Farto

Subjects
Voto por correspondência, The right to vote, Vote by corresponde, Voto by correspondence legal framework, Ciências Sociais::Direito [Domínio/Área Científica], Regime jurídico do voto por correspondência, Direito de voto
Abstract

Submitted by Cristina Afonso (cac@lisboa.ucp.pt) on 2018-12-19T16:37:48Z No. of bitstreams: 1 Dissertação Natacha.pdf: 573280 bytes, checksum: 8db3546c5d5c4eb630bb580d77a2f3dc (MD5) Approved for entry into archive by Cristina Afonso (cac@lisboa.ucp.pt) on 2018-12-19T16:37:59Z (GMT) No. of bitstreams: 1 Dissertação Natacha.pdf: 573280 bytes, checksum: 8db3546c5d5c4eb630bb580d77a2f3dc (MD5) Made available in DSpace on 2018-12-19T16:37:59Z (GMT). No. of bitstreams: 1 Dissertação Natacha.pdf: 573280 bytes, checksum: 8db3546c5d5c4eb630bb580d77a2f3dc (MD5) Previous issue date: 2018-10-16

Published
2018

38. Acordos de recompra

Author

Silva, Andreia Patrícia Ferreira da and Baptista, Daniela Farto

Subjects
Contrato de reporte, Repurchase agreements, Articles 477 and 478 portuguese civil code, DMIF II, Repo contracts, Ciências Sociais::Direito [Domínio/Área Científica], Acordos de recompra, MiDIF II, Art.477º e 478º Código Civil Português
Abstract

Submitted by Cristina Afonso (cac@lisboa.ucp.pt) on 2019-11-14T14:05:59Z No. of bitstreams: 1 tese andreia.pdf: 1333922 bytes, checksum: e4e27b53ebce006620a2ce0e1a10f244 (MD5) Approved for entry into archive by Cristina Afonso (cac@lisboa.ucp.pt) on 2019-11-14T14:06:13Z (GMT) No. of bitstreams: 1 tese andreia.pdf: 1333922 bytes, checksum: e4e27b53ebce006620a2ce0e1a10f244 (MD5) Made available in DSpace on 2019-11-14T14:06:13Z (GMT). No. of bitstreams: 1 tese andreia.pdf: 1333922 bytes, checksum: e4e27b53ebce006620a2ce0e1a10f244 (MD5) Previous issue date: 2018-02-06

Published
2018

39. Genome-Wide Meta-Analysis Unravels Interactions between Magnesium Homeostasis and Metabolic Phenotypes

Author

Rosa Vargas-Poussou, Igor Rudan, Paolo Gasparini, Ian J. Deary, Joost G. J. Hoenderop, Olivier Devuyst, Aurélien Macé, Menno Pruijm, John M. Starr, Huguette Debaix, Martin Konrad, Jeroen H. F. de Baaij, Stefania Lenarduzzi, Sheila Ulivi, Ozren Polasek, Daniel Ackermann, Rico Rueedi, David Lamparter, Nicholas D. Hastie, Caroline Hayward, Gérard Waeber, Tanguy Corre, Daniela Baptista, Toby W. Hurd, Zoltán Kutalik, Murielle Bochud, Sonia Youhanna, Hendrica Belge, Peter Vollenweider, Sven Bergmann, Maxime G. Blanchard, Michela Traglia, Belen Ponte, René J. M. Bindels, Francisco J. Arjona, Veronique Vitart, Daniela Toniolo, Cinzia Sala, Nadine Nägele, Sarah E. Harris, Georg Ehret, Corre, Tanguy, Arjona, Francisco J., Hayward, Caroline, Youhanna, Sonia, De Baaij, Jeroen H. F., Belge, Hendrica, Nägele, Nadine, Debaix, Huguette, Blanchard, Maxime G., Traglia, Michela, Harris, Sarah E., Ulivi, Sheila, Rueedi, Rico, Lamparter, David, Macé, Aurélien, Sala, Cinzia, Lenarduzzi, Stefania, Ponte, Belen, Pruijm, Menno, Ackermann, Daniel, Ehret, Georg, Baptista, Daniela, Polasek, Ozren, Rudan, Igor, Hurd, Toby W., Hastie, Nicholas D., Vitart, Veronique, Waeber, Geràrd, Kutalik, Zoltán, Bergmann, Sven, Vargas-Poussou, Rosa, Konrad, Martin, Gasparini, Paolo, Deary, Ian J., Starr, John M., Toniolo, Daniela, Vollenweider, Peter, Hoenderop, Joost G. J., Bindels, René J. M., Bochud, Murielle, and Devuyst, Olivier

Subjects
0301 basic medicine, Magnesium homeostasis, Kidney, Genetic determinants, Mice, Homeostasis, Insulin, Magnesium, 610 Medicine & health, Zebrafish, Adiposity, ddc:616, DOUBLE-BLIND, SECONDARY HYPOCALCEMIA, NONDIABETIC SUBJECTS, INSULIN SENSITIVITY, CONTROLLED-TRIALS, RANDOMIZED-TRIAL, GENETIC-LOCI, ZEBRAFISH, SUPPLEMENTATION, HYPOMAGNESEMIA, education.field_of_study, Gene knockdown, Genetic determinant, ADP-Ribosylation Factors, General Medicine, Metabolic syndrome, Phenotype, Magnesium homeostasi, Nephrology, medicine.medical_specialty, Population, TRPM Cation Channels, Biology, Polymorphism, Single Nucleotide, 03 medical and health sciences, Insulin resistance, GTP-Binding Proteins, Internal medicine, TRPM6, medicine, Tubular transport, Animals, Humans, Obesity, RNA, Messenger, education, Zebrafish Proteins, zebrafish, medicine.disease, biology.organism_classification, Gene-environment interaction, 030104 developmental biology, Endocrinology, Renal disorders Radboud Institute for Molecular Life Sciences [Radboudumc 11], 570 Life sciences, biology, Gene-Environment Interaction, Insulin Resistance, Meta-Analysis, Genome-Wide Association Study
Abstract

Contains fulltext : 184156.pdf (Publisher’s version ) (Closed access) Magnesium (Mg(2+)) homeostasis is critical for metabolism. However, the genetic determinants of the renal handling of Mg(2+), which is crucial for Mg(2+) homeostasis, and the potential influence on metabolic traits in the general population are unknown. We obtained plasma and urine parameters from 9099 individuals from seven cohorts, and conducted a genome-wide meta-analysis of Mg(2+) homeostasis. We identified two loci associated with urinary magnesium (uMg), rs3824347 (P=4.4x10(-13)) near TRPM6, which encodes an epithelial Mg(2+) channel, and rs35929 (P=2.1x10(-11)), a variant of ARL15, which encodes a GTP-binding protein. Together, these loci account for 2.3% of the variation in 24-hour uMg excretion. In human kidney cells, ARL15 regulated TRPM6-mediated currents. In zebrafish, dietary Mg(2+) regulated the expression of the highly conserved ARL15 ortholog arl15b, and arl15b knockdown resulted in renal Mg(2+) wasting and metabolic disturbances. Finally, ARL15 rs35929 modified the association of uMg with fasting insulin and fat mass in a general population. In conclusion, this combined observational and experimental approach uncovered a gene-environment interaction linking Mg(2+) deficiency to insulin resistance and obesity. 01 januari 2018

Published
2018
Full Text
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40. Corporate governance : a influência e responsabilização do empty creditor

Author

Pereira, Sofia Carvalhais Leite and Baptista, Daniela Farto

Subjects
Credor vazio, Credit default swaps, Financiamento das sociedades, Financing of companies, Ciências Sociais::Direito [Domínio/Área Científica], Empty creditor
Abstract

Submitted by Cristina Afonso (cac@lisboa.ucp.pt) on 2017-12-20T09:35:49Z No. of bitstreams: 1 tese.pdf: 602306 bytes, checksum: c1f23539acabfa9f78387d68f21e7332 (MD5) Made available in DSpace on 2017-12-20T09:35:49Z (GMT). No. of bitstreams: 1 tese.pdf: 602306 bytes, checksum: c1f23539acabfa9f78387d68f21e7332 (MD5) Previous issue date: 2017-12-30

Published
2017

41. Alteração de circunstâncias no âmbito de uma OPA em curso

Author

Mota, Pedro Nuno Sarmento Leitão da and Baptista, Daniela Farto

Subjects
Ciências Sociais::Direito [Domínio/Área Científica]
Abstract

Submitted by Cristina Afonso (cac@lisboa.ucp.pt) on 2017-10-25T15:03:28Z No. of bitstreams: 1 Tese-PedroLeitaodaMota.pdf: 916799 bytes, checksum: 4883358883ad9d6b467330f2fa84dc18 (MD5) Approved for entry into archive by Cristina Afonso (cac@lisboa.ucp.pt) on 2017-10-25T15:04:26Z (GMT) No. of bitstreams: 1 Tese-PedroLeitaodaMota.pdf: 916799 bytes, checksum: 4883358883ad9d6b467330f2fa84dc18 (MD5) Made available in DSpace on 2017-10-25T15:04:26Z (GMT). No. of bitstreams: 1 Tese-PedroLeitaodaMota.pdf: 916799 bytes, checksum: 4883358883ad9d6b467330f2fa84dc18 (MD5) Previous issue date: 2017-05-15

Published
2017

42. Sociedades abertas : algumas questões levantadas pelo Insider Trading em Portugal

Author

Fonseca, Rodrigo Sá Pereira Ribeiro da and Baptista, Daniela Farto

Subjects
Ciências Sociais::Direito [Domínio/Área Científica]
Abstract

Submitted by Cristina Afonso (cac@lisboa.ucp.pt) on 2017-11-02T11:00:48Z No. of bitstreams: 1 Tese final Rodrigo.pdf: 759736 bytes, checksum: 738a036a43dd10eca8407305cea2e8aa (MD5) Approved for entry into archive by Cristina Afonso (cac@lisboa.ucp.pt) on 2017-11-02T11:01:01Z (GMT) No. of bitstreams: 1 Tese final Rodrigo.pdf: 759736 bytes, checksum: 738a036a43dd10eca8407305cea2e8aa (MD5) Made available in DSpace on 2017-11-02T11:01:01Z (GMT). No. of bitstreams: 1 Tese final Rodrigo.pdf: 759736 bytes, checksum: 738a036a43dd10eca8407305cea2e8aa (MD5) Previous issue date: 2017-05-15

Published
2017

43. Transposição da DMIF I no ordenamento jurídico português

Author

Regado, Gabriela Baptista and Baptista, Daniela Farto

Subjects
Ciências Sociais::Direito [Domínio/Área Científica]
Abstract

Submitted by Cristina Afonso (cac@lisboa.ucp.pt) on 2017-12-18T15:46:24Z No. of bitstreams: 1 Transposição da DMIF I no ordenamento jurídico português.pdf: 1205384 bytes, checksum: 6167e39e6109acb032e425e8497c6df9 (MD5) Made available in DSpace on 2017-12-18T15:46:24Z (GMT). No. of bitstreams: 1 Transposição da DMIF I no ordenamento jurídico português.pdf: 1205384 bytes, checksum: 6167e39e6109acb032e425e8497c6df9 (MD5) Previous issue date: 2017

Published
2017

44. Opa obrigatório nas relações de grupo : grupos de facto

Author

Silva, Ana Isabel Agarez Monteiro Cerca da and Baptista, Daniela Farto

Subjects
Ciências Sociais::Direito [Domínio/Área Científica]
Abstract

Submitted by Cristina Afonso (cac@lisboa.ucp.pt) on 2017-11-02T10:27:17Z No. of bitstreams: 1 OPAs Obrigatórias nas Relações de Grupo (1).pdf: 1006889 bytes, checksum: 33b0d631ec5b0e16a096ce6f5d645f20 (MD5) Approved for entry into archive by Cristina Afonso (cac@lisboa.ucp.pt) on 2017-11-02T10:27:30Z (GMT) No. of bitstreams: 1 OPAs Obrigatórias nas Relações de Grupo (1).pdf: 1006889 bytes, checksum: 33b0d631ec5b0e16a096ce6f5d645f20 (MD5) Made available in DSpace on 2017-11-02T10:27:30Z (GMT). No. of bitstreams: 1 OPAs Obrigatórias nas Relações de Grupo (1).pdf: 1006889 bytes, checksum: 33b0d631ec5b0e16a096ce6f5d645f20 (MD5) Previous issue date: 2017-05-09

Published
2017

45. As relações de domínio nas sociedades fechadas e nas sociedades abertas : análise do artigo 486º do CSC e do artigo 21º do CVM

Author

Costa, Ana Sofia Navio dos Santos and Baptista, Daniela Farto

Subjects
Ciências Sociais::Direito [Domínio/Área Científica]
Abstract

Submitted by Cristina Afonso (cac@lisboa.ucp.pt) on 2017-11-02T10:14:37Z No. of bitstreams: 1 TESE - Versão Final PDF-A.pdf: 899598 bytes, checksum: 080499020dcdb55564e014396b25ecf3 (MD5) Approved for entry into archive by Cristina Afonso (cac@lisboa.ucp.pt) on 2017-11-02T10:14:48Z (GMT) No. of bitstreams: 1 TESE - Versão Final PDF-A.pdf: 899598 bytes, checksum: 080499020dcdb55564e014396b25ecf3 (MD5) Made available in DSpace on 2017-11-02T10:14:49Z (GMT). No. of bitstreams: 1 TESE - Versão Final PDF-A.pdf: 899598 bytes, checksum: 080499020dcdb55564e014396b25ecf3 (MD5) Previous issue date: 2017-12-15

Published
2017

46. Ações preferenciais sem direito de voto

Author

Oliveira, João Paulo de Sousa and Baptista, Daniela Farto

Subjects
Ciências Sociais::Direito [Domínio/Área Científica]
Abstract

Submitted by Cristina Afonso (cac@lisboa.ucp.pt) on 2017-12-19T14:03:49Z No. of bitstreams: 1 tese final PDFA.pdf: 575474 bytes, checksum: b8680bbb4f9f44a24fc206531161b8a8 (MD5) Made available in DSpace on 2017-12-19T14:03:49Z (GMT). No. of bitstreams: 1 tese final PDFA.pdf: 575474 bytes, checksum: b8680bbb4f9f44a24fc206531161b8a8 (MD5) Previous issue date: 2017-05-15

Published
2017

47. Governo das instituições de crédito

Author

Carvalheira, Ana Bárbara Soares and Baptista, Daniela Farto

Subjects
Ciências Sociais::Direito [Domínio/Área Científica]
Abstract

Submitted by Cristina Afonso (cac@lisboa.ucp.pt) on 2017-09-08T08:26:45Z No. of bitstreams: 1 Governo das Instituições de Crédito.pdf: 1122573 bytes, checksum: 9c9023f51fe2049f3a741af33017825d (MD5) Approved for entry into archive by Cristina Afonso (cac@lisboa.ucp.pt) on 2017-09-08T08:26:53Z (GMT) No. of bitstreams: 1 Governo das Instituições de Crédito.pdf: 1122573 bytes, checksum: 9c9023f51fe2049f3a741af33017825d (MD5) Made available in DSpace on 2017-09-08T08:26:53Z (GMT). No. of bitstreams: 1 Governo das Instituições de Crédito.pdf: 1122573 bytes, checksum: 9c9023f51fe2049f3a741af33017825d (MD5) Previous issue date: 2016-12-23

Published
2016

48. O artigo 490.º n.º 5 do Código das Sociedades Comerciais : direito potestativo de alienação ou direito de exoneração dos sócios?

Author

Borges, Carlota Gonçalves and Baptista, Daniela

Subjects
Ciências Sociais::Direito [Domínio/Área Científica], Aquisições tendentes ao domínio total, Direito de exoneração, Direito potestativo de alienação
Abstract

Submitted by Cristina Afonso (cac@lisboa.ucp.pt) on 2017-04-04T14:49:32Z No. of bitstreams: 1 Dissertação de Mestrado - Carlota Gonçalves Borges.pdf: 981411 bytes, checksum: aad4bba219444fdfb92517702fa53411 (MD5) Approved for entry into archive by Cristina Afonso (cac@lisboa.ucp.pt) on 2017-04-04T14:49:47Z (GMT) No. of bitstreams: 1 Dissertação de Mestrado - Carlota Gonçalves Borges.pdf: 981411 bytes, checksum: aad4bba219444fdfb92517702fa53411 (MD5) Made available in DSpace on 2017-04-04T14:49:47Z (GMT). No. of bitstreams: 1 Dissertação de Mestrado - Carlota Gonçalves Borges.pdf: 981411 bytes, checksum: aad4bba219444fdfb92517702fa53411 (MD5) Previous issue date: 2016-12-22

Published
2016

49. Direito de subscrição preferencial no aumento de capital por novas entradas : breves reflexões acerca do seu regime

Author

Alves, Ana Sofia Silva Neves and Baptista, Daniela Farto

Subjects
Ciências Sociais::Direito [Domínio/Área Científica]
Abstract

Submitted by Cristina Afonso (cac@lisboa.ucp.pt) on 2017-04-04T13:50:05Z No. of bitstreams: 1 ANA FERREIRA DA SILVA - A RESPONSABILIDADE DA SOCIEDADE DIRETORA PARA COM OS CREDORES DA SOCIEDADE SUBORDINADA- O ART. 501.º DO CSC (PDF).pdf: 365669 bytes, checksum: b8fe0751e41063825b6e94585dc30ed9 (MD5) Approved for entry into archive by Cristina Afonso (cac@lisboa.ucp.pt) on 2017-04-04T13:50:15Z (GMT) No. of bitstreams: 1 ANA FERREIRA DA SILVA - A RESPONSABILIDADE DA SOCIEDADE DIRETORA PARA COM OS CREDORES DA SOCIEDADE SUBORDINADA- O ART. 501.º DO CSC (PDF).pdf: 365669 bytes, checksum: b8fe0751e41063825b6e94585dc30ed9 (MD5) Made available in DSpace on 2017-04-04T13:50:15Z (GMT). No. of bitstreams: 1 ANA FERREIRA DA SILVA - A RESPONSABILIDADE DA SOCIEDADE DIRETORA PARA COM OS CREDORES DA SOCIEDADE SUBORDINADA- O ART. 501.º DO CSC (PDF).pdf: 365669 bytes, checksum: b8fe0751e41063825b6e94585dc30ed9 (MD5) Previous issue date: 2016-10-17

Published
2016

50. Insider trading : a importação de um conceito norte-americano e o seu enquadramento no ordenamento jurídico português

Author

Espinhaço, João Telmo Marques and Baptista, Daniela Farto

Subjects
Ciências Sociais::Direito [Domínio/Área Científica]
Abstract

Submitted by Cristina Afonso (cac@lisboa.ucp.pt) on 2017-02-23T11:41:57Z No. of bitstreams: 1 Dissertação - insider trading.pdf: 401459 bytes, checksum: d782d6f61365a90ccc7732e6853174b8 (MD5) Approved for entry into archive by Cristina Afonso (cac@lisboa.ucp.pt) on 2017-02-23T11:42:06Z (GMT) No. of bitstreams: 1 Dissertação - insider trading.pdf: 401459 bytes, checksum: d782d6f61365a90ccc7732e6853174b8 (MD5) Made available in DSpace on 2017-02-23T11:42:06Z (GMT). No. of bitstreams: 1 Dissertação - insider trading.pdf: 401459 bytes, checksum: d782d6f61365a90ccc7732e6853174b8 (MD5) Previous issue date: 2016-10-13

Published
2016

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