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1. Automated iterative Csp3–C bond formation

Author

Blair, Daniel J., Chitti, Sriyankari, Trobe, Melanie, Kostyra, David M., Haley, Hannah M. S., Hansen, Richard L., Ballmer, Steve G., Woods, Toby J., Wang, Wesley, Mubayi, Vikram, Schmidt, Michael J., Pipal, Robert W., Morehouse, Greg. F., Palazzolo Ray, Andrea M. E., Gray, Danielle L., Gill, Adrian L., and Burke, Martin D.

Published
2022
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2. Abstract 1598: RM-046, a first-in-class, mutant-selective, and oral KRASQ61H(ON) inhibitor that drives tumor regression in preclinical models and validates KRASQ61H as a therapeutic target

Author

Yang, Yu C., primary, Thompson, Severin, additional, Montgomery, David, additional, Quiñones, Antonio J., additional, Wei, Xing, additional, Madej, Benjamin, additional, Tomlinson, Aidan, additional, Shifrin, Nataliya T., additional, McNamara, Alexander, additional, Ahler, Ethan, additional, McDowell, Laura L., additional, Flagella, Michael, additional, Setser, John, additional, Chang, Stephanie, additional, Wang, Zhican, additional, Wang, Zhengping, additional, Huang, Jun, additional, Ballmer, Steve, additional, li, Shaong, additional, Buckl, Andreas, additional, Koltun, Elena, additional, Gill, Adrian, additional, Jiang, Jingjing, additional, Singh, Mallika, additional, and Smith, Jacqueline A., additional

Published
2023
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3. Automated iterative Csp3–C bond formation.

Author

Blair, Daniel J., Chitti, Sriyankari, Trobe, Melanie, Kostyra, David M., Haley, Hannah M. S., Hansen, Richard L., Ballmer, Steve G., Woods, Toby J., Wang, Wesley, Mubayi, Vikram, Schmidt, Michael J., Pipal, Robert W., Morehouse, Greg. F., Palazzolo Ray, Andrea M. E., Gray, Danielle L., Gill, Adrian L., and Burke, Martin D.

Abstract

Fully automated synthetic chemistry would substantially change the field by providing broad on-demand access to small molecules. However, the reactions that can be run autonomously are still limited. Automating the stereospecific assembly of Csp3–C bonds would expand access to many important types of functional organic molecules1. Previously, methyliminodiacetic acid (MIDA) boronates were used to orchestrate the formation of Csp2–Csp2 bonds and were effective building blocks for automating the synthesis of many small molecules2, but they are incompatible with stereospecific Csp3–Csp2 and Csp3–Csp3 bond-forming reactions3–10. Here we report that hyperconjugative and steric tuning provide a new class of tetramethyl N-methyliminodiacetic acid (TIDA) boronates that are stable to these conditions. Charge density analysis11–13 revealed that redistribution of electron density increases covalency of the N–B bond and thereby attenuates its hydrolysis. Complementary steric shielding of carbonyl π-faces decreases reactivity towards nucleophilic reagents. The unique features of the iminodiacetic acid cage2, which are essential for generalized automated synthesis, are retained by TIDA boronates. This enabled Csp3 boronate building blocks to be assembled using automated synthesis, including the preparation of natural products through automated stereospecific Csp3–Csp2 and Csp3–Csp3 bond formation. These findings will enable increasingly complex Csp3-rich small molecules to be accessed via automated assembly.Identification of a hyperstable boronate enables automated lego-like synthesis to access a wider range of three-dimensionally complex small organic molecules rich in Csp3–C bonds. [ABSTRACT FROM AUTHOR]

Published
2022
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4. How Philanthropy Can Enable Social Workers to Do More Good

Author

Ballmer, Connie and Ballmer, Steve

Subjects
Philanthropy, Child welfare, Social workers, Nonprofit organizations, Public transportation, Sociology and social work
Abstract

CONSIDER an American family struggling to experience the American Dream of economic mobility, yet repeatedly running into setbacks. Mom is working three jobs and must constantly find new ones because [...]

Published
2018

5. A Breakup Is Too Harsh: And will keep us from doing what we do best: innovating

Author

Ballmer, Steve

Subjects
Microsoft Corp. -- Cases, Cases, Company legal issue, Antitrust issue, Software industry -- Cases, Antitrust law -- Cases, Computer software industry -- Cases
Abstract

Anyone who uses a personal computer, cares about preserving America's leadership in technology or is concerned about overreaching government regulation should take a close look at the government's proposal to [...]

Published
2000

6. 'The only way to calm the doubters is by delivering'

Author

Ballmer, Steve

Subjects
Banking, finance and accounting industries, Business, Business, international
Abstract

What went wrong with Windows Vista? We made a set of decisions to improve security: those improvements came at the price of a level of compatibility with [Windows] XP. I'm [...]

Published
2009

7. Maybe I'm an emblem of an old era

Author

Ballmer, Steve

Subjects
Microsoft Corp. -- Officials and employees, Computer software industry -- Officials and employees, Chief executive officers -- Quotations, General interest, News, opinion and commentary
Abstract

'Maybe I'm an emblem of an old era and I have to move on' --Steve Ballmer, co-founder and former CEO of Microsoft, in an interview about his after 13 years [...]

Published
2013

8. Delivering value to cable

Author

Ballmer, Steve

Subjects
Business, Mass communications
Abstract

Welcome to Cable 2002, the 51st annual NCTA convention. Microsoft has long recognized the promise of cable, and the opportunity for software to help connect and bring to life the [...]

Published
2002

9. On Vista, virtualization and open vows.

Author

Ballmer, Steve

Subjects
*SQL
Abstract

The article presents an interview with Steve Ballmer, chief executive officer (CEO) of Microsoft, in the U.S. When asked about the impact of the launching of Windows Server 2008, SQL Server 2008 and Visual Studio 2008 to the company's market positioning, he replied that the company is still young and still got all the best years ahead of them. He added that 70% of enterprise are writing Net applications and SQL Server has the biggest share of unifying database market.

Published
2008

10. Permanent Press.

Author

BALLMER, STEVE

Subjects
ELECTRONIC books, BOOK sales & prices, BOOKS & reading, MARKET share, ELECTRONIC book readers
Abstract

The article looks at electronic books (e-books) and the book publishing industry. It discusses the pace at which readers of various genres have switched to e-books since the introduction of e-book readers such as the Amazon Kindle. Two graphs with data on trends for the period 2009 to 2013 are included, the prices of print books versus e-books and e-book sales as a share of total book sales for several countries.

Published
2015

11. A $5 BILLION VOTE OF CONFIDENCE.

Author

Ballmer, Steve

Subjects
*BUSINESS planning, *HIGH technology industries
Abstract

Presents business plans for Microsoft Corp. in the year 2003. Emphasis on increasing productivity, reliability and security; Increase investment in the high-tech industry; Launch of Window Server 2003, a server platform for powering connected applications.

Published
2003

12. Four Pillars of Excellence.

Author

Ballmer, Steve

Subjects
BUSINESS success, EMPLOYEE motivation, EMPLOYEE recruitment
Abstract

Discusses the four pillars to business success. Importance of having a clear vision; Need to motivate employees; Recruitment of people who share the company's vision and priorities.

Published
2002

13. Thriving Today.

Author

Ballmer, Steve

Subjects
LEADERSHIP, ECONOMIC development, INFORMATION technology, TECHNOLOGICAL innovations
Abstract

The article presents concepts for leaders in order to engineer economic growth in the information technology (IT) industry. It highlights real productivity growth coming from investments in IT in the U.S. economy. Innovation growth is anticipated with more jobs created in IT than in the economy at large. Possibilities for the future are noted in terms of developing the talent needed within an invention culture.

Published
2009

14. Embrace Innovation.

Author

Ballmer, Steve

Subjects
TECHNOLOGICAL innovations, BUSINESS, AUTOMOBILE industry, INFORMATION technology
Abstract

Focuses on the benefits of innovation for the business in the U.S. Acceptance of innovation in business; Innovation in the automobile industry; Evolution in the information technology industry.

Published
2004

15. Exchange: Steve Ballmer.

Author

Ballmer, Steve

Subjects
INFORMATION technology, COMPUTER operating systems
Abstract

Presents comments of Steve Dallmer, Chief executive officer at U.S.-based Microsoft Corp., regarding the developments in computer technology. Similarity in Linux operating system and StarOffice operating system; Comparison in compatibility of Windows and Linux; Enhancement in the technology of digital rights management.

Published
2002

16. NC no threat.

Author

Ballmer, Steve

Subjects
*NETWORK PC (Computer)
Abstract

Presents an interview with Steve Ballmer, Microsoft Corp.'s executive vice president of sales. Company's long-term plans regarding the Windows operating system; The Internet; Thin client network computers (NC).

Published
1996

17. Today's debate: Ruling against Microsoft.

Author

Ballmer, Steve

Abstract

Debates on the United States District Court Judge Thomas Penfield Jackson's ruling on the antitrust case of Microsoft Corporation. Highlights of the case; Its significance; Reasons the decision against the company is wrong.

Published
2000

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