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2. Multi-population genome-wide association study implicates immune and non-immune factors in pediatric steroid-sensitive nephrotic syndrome

Author

Barry, Alexandra, McNulty, Michelle T., Jia, Xiaoyuan, Gupta, Yask, Debiec, Hanna, Luo, Yang, Nagano, China, Horinouchi, Tomoko, Jung, Seulgi, Colucci, Manuela, Ahram, Dina F., Mitrotti, Adele, Sinha, Aditi, Teeninga, Nynke, Jin, Gina, Shril, Shirlee, Caridi, Gianluca, Bodria, Monica, Lim, Tze Y., Westland, Rik, Zanoni, Francesca, Marasa, Maddalena, Turudic, Daniel, Giordano, Mario, Gesualdo, Loreto, Magistroni, Riccardo, Pisani, Isabella, Fiaccadori, Enrico, Reiterova, Jana, Maringhini, Silvio, Morello, William, Montini, Giovanni, Weng, Patricia L., Scolari, Francesco, Saraga, Marijan, Tasic, Velibor, Santoro, Domenica, van Wijk, Joanna A. E., Milošević, Danko, Kawai, Yosuke, Kiryluk, Krzysztof, Pollak, Martin R., Gharavi, Ali, Lin, Fangmin, Simœs e Silva, Ana Cristina, Loos, Ruth J. F., Kenny, Eimear E., Schreuder, Michiel F., Zurowska, Aleksandra, Dossier, Claire, Ariceta, Gema, Drozynska-Duklas, Magdalena, Hogan, Julien, Jankauskiene, Augustina, Hildebrandt, Friedhelm, Prikhodina, Larisa, Song, Kyuyoung, Bagga, Arvind, Cheong, II, Hae, Ghiggeri, Gian Marco, Vachvanichsanong, Prayong, Nozu, Kandai, Lee, Dongwon, Vivarelli, Marina, Raychaudhuri, Soumya, Tokunaga, Katsushi, Sanna-Cherchi, Simone, Ronco, Pierre, Iijima, Kazumoto, and Sampson, Matthew G.

Published
2023
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3. A Focus Group Study of Self-Management in Patients With Glomerular Disease

Author

Carter, Simon A, Teng, Claris, Gutman, Talia, Logeman, Charlotte, Cattran, Dan, Lightstone, Liz, Bagga, Arvind, Barbour, Sean J, Barratt, Jonathan, Boletis, John, Caster, Dawn J, Coppo, Rosanna, Fervenza, Fernando C, Floege, Jürgen, Hladunewich, Michelle A, Hogan, Jonathan J, Kitching, A Richard, Lafayette, Richard A, Malvar, Ana, Radhakrishnan, Jai, Rovin, Brad H, Scholes-Robertson, Nicole, Trimarchi, Hernán, Zhang, Hong, Azukaitis, Karolis, Cho, Yeoungjee, Viecelli, Andrea K, Dunn, Louese, Harris, David, Johnson, David W, Kerr, Peter G, Laboi, Paul, Ryan, Jessica, Shen, Jenny I, Ruiz, Lorena, Wang, Angela Yee-Moon, Lee, Achilles Hoi Kan, Shun, Samuel Fung Ka, Tong, Matthew Ka-Hang, Teixeira-Pinto, Armando, Wilkie, Martin, Alexander, Stephen I, Craig, Jonathan C, Martin, Adam, and Tong, Allison

Subjects
Health Services and Systems, Health Sciences, Behavioral and Social Science, Health Services, Clinical Research, Management of diseases and conditions, 7.1 Individual care needs, Good Health and Well Being, focus groups, glomerulonephritis, personal autonomy, self-management, therapeutic alliance, Biomedical and clinical sciences, Health sciences
Abstract

IntroductionPatients with glomerular disease experience symptoms that impair their physical and mental health while managing their treatments, diet, appointments and monitoring general and specific indicators of health and their illness. We sought to describe the perspectives of patients and their care partners on self-management in glomerular disease.MethodsWe conducted 16 focus groups involving adult patients with glomerular disease (n = 101) and their care partners (n = 34) in Australia, Hong Kong, the United Kingdom, and United States. Transcripts were analyzed thematically.ResultsWe identified the following 4 themes: empowered in autonomy (gaining confidence through understanding, taking ownership of disease and treatment, learning a positive health approach); overwhelmed by compounding treatment burdens (financially undermined and depleted, demoralized by side effects and harms, frustrated by fragmented and inflexible care, fear of possible drug harms); striving for stability and normalcy (making personal sacrifices, maximizing life participation, attentiveness to bodily signs, avoiding precarious health states, integrating medicines into routines); and necessity of health-sustaining relationships (buoyed by social support, fulfilling meaningful responsibilities, sharing and normalizing experiences, seeking a trusting and respectful alliance).ConclusionPatients with glomerular disease and their care partners value their capacity for autonomy and disease ownership, stability of their health, and relationships that support self-management. Strategies directed at strengthening these factors may increase self-efficacy and improve the care and outcomes for patients with glomerular disease.

Published
2022

9. Recognition and management of acute kidney injury in children: The ISN 0by25 Global Snapshot study

Author

Macedo, Etienne, Cerdá, Jorge, Hingorani, Sangeeta, Hou, Jiayi, Bagga, Arvind, Burdmann, Emmanuel Almeida, V., Michael Rocco, and L., Ravindra Mehta

Subjects
Biomedical and Clinical Sciences, Clinical Sciences, Health Sciences, Kidney Disease, Clinical Research, Pediatric, 2.4 Surveillance and distribution, Aetiology, Renal and urogenital, Good Health and Well Being, Acute Kidney Injury, Child, Child, Preschool, Cross-Sectional Studies, Female, Humans, Income, Infant, Internationality, Male, General Science & Technology
Abstract

BackgroundIn low and middle-income countries, reliable data on the epidemiology of childhood acute kidney injury (AKI) is lacking. The Global Snapshot, conducted by the ISN "0by25" AKI initiative, was a world-wide cross-sectional, observational study to evaluate AKI in hospitalized patients. Here we report the pediatric results of this study.Patients and methodsWe prospectively collected data on children who met the Kidney Disease Improving Global Outcomes AKI criteria during a 10-week window in late 2014. AKI risk factors, etiological factors, management and outcomes were recorded using standardized forms and protocols. Countries were classified according to their 2014 gross national income (GNI) per person into high-income countries (HIC), upper-middle income countries (UMIC) and low and low-middle income countries (LLMIC). Need for renal replacement therapy, mortality, and renal recovery were assessed 7 days after AKI diagnosis or at hospital discharge, whichever came first.Results92 centers from 41 countries collected data on 354 pediatric AKI patients; 53% of the children developed AKI while hospitalized and 47% in the community. The most common etiological factors for AKI differed across GNI categories as well as between patients with community-acquired vs. hospital-acquired AKI. Children from HIC were younger, and larger proportion of AKI in this group were due to post-surgical complications vs. other etiologies when compared to other income categories. In patients with hypotension as the cause of AKI, the adjusted risk of death was almost 10-fold higher compared to patients without hypotension as an etiological factor for AKI development. Mortality was similar within AKI stages in HIC and UMIC. In LLMIC, patients with the highest AKI level of severity had higher mortality than patients in higher income categories. Patients from LLMIC and UMIC had a 57-fold and 11 fold higher adjusted risk of death, respectively, compared to patients from HIC.ConclusionIn resource-limited countries, pediatric AKI-associated mortality is disproportionately higher when compared to high-resource areas, especially among patients with more severe AKI.

Published
2018

11. Development of an international Delphi survey to establish core outcome domains for trials in adults with glomerular disease

Author

Carter, Simon A., Logeman, Charlotte, Howell, Martin, Cattran, Dan, Lightstone, Liz, Bagga, Arvind, Barbour, Sean J., Barratt, Jonathan, Boletis, John, Caster, Dawn J., Coppo, Rosanna, Fervenza, Fernando C., Floege, Jürgen, Hladunewich, Michelle A., Hogan, Jonathan J., Kitching, A. Richard, Lafayette, Richard A., Malvar, Ana, Radhakrishnan, Jai, Rovin, Brad H., Scholes-Robertson, Nicole, Trimarchi, Hérnan, Zhang, Hong, Cho, Yeoungjee, Dunn, Louese, Gipson, Debbie S., Liew, Adrian, Sautenet, Benedicte, Viecelli, Andrea K., Harris, David, Johnson, David W., Wang, Angela Yee-Moon, Teixeira-Pinto, Armando, Alexander, Stephen I., Martin, Adam, Tong, Allison, and Craig, Jonathan C.

Published
2021
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16. Acute Kidney Injury Risk Assessment: Differences and Similarities Between Resource-Limited and Resource-Rich Countries

Author

Kashani, Kianoush, Macedo, Etienne, Burdmann, Emmanuel A, Hooi, Lai Seong, Khullar, Dinesh, Bagga, Arvind, Chakravarthi, Rajasekara, Mehta, Ravindra, and Group, Acute Disease Quality Initiative Consensus

Subjects
Health Services and Systems, Health Sciences, Prevention, Kidney Disease, Patient Safety, Clinical Research, Aetiology, 2.4 Surveillance and distribution, Renal and urogenital, Good Health and Well Being, acute kidney injury, acute renal failure, developed countries, developing countries, risk assessment, outcomes, Biomedical and clinical sciences, Health sciences
Abstract

The incidence of acute kidney injury (AKI) among acutely ill patients is reportedly very high and has vexing consequences on patient outcomes and health care systems. The risks and impact of AKI differ between developed and developing countries. Among developing countries, AKI occurs in young individuals with no or limited comorbidities, and is usually due to environmental causes, including infectious diseases. Although several risk factors have been identified for AKI in different settings, there is limited information on how risk assessment can be used at population and patient levels to improve care in patients with AKI, particularly in developing countries where significant health disparities may exist. The Acute Disease Quality Initiative consensus conference work group addressed the issue of identifying risk factors for AKI and provided recommendations for developing individualized risk stratification strategies to improve care. We proposed a 5-dimension, evidence-based categorization of AKI risk that allows clinicians and investigators to study, define, and implement individualized risk assessment tools for the region or country where they practice. These dimensions include environmental, socioeconomic and cultural factors, processes of care, exposures, and the inherent risks of AKI. We provide examples of these risks and describe approaches for risk assessments in the developing world. We anticipate that these recommendations will be useful for health care providers to plan and execute interventions to limit the impact of AKI on society and each individual patient. Using a modified Delphi process, this group reached consensus regarding several aspects of AKI risk stratification.

Published
2017

19. Global Burden of Cardiovascular Diseases and Risks, 1990-2022

Author

Mensah, George A., primary, Fuster, Valentin, additional, Murray, Christopher J.L., additional, Roth, Gregory A., additional, Mensah, George A., additional, Abate, Yohannes Habtegiorgis, additional, Abbasian, Mohammadreza, additional, Abd-Allah, Foad, additional, Abdollahi, Ashkan, additional, Abdollahi, Mohammad, additional, Abdulah, Deldar Morad, additional, Abdullahi, Auwal, additional, Abebe, Ayele Mamo, additional, Abedi, Aidin, additional, Abedi, Armita, additional, Abiodun, Olugbenga Olusola, additional, Ali, Hiwa Abubaker, additional, Abu-Gharbieh, Eman, additional, Abu-Rmeileh, Niveen M.E., additional, Aburuz, Salahdein, additional, Abushouk, Abdelrahman I., additional, Abu-Zaid, Ahmed, additional, Adane, Tigist Demssew, additional, Adderley, Nicola J., additional, Adebayo, Oladimeji M., additional, Aden, Bashir, additional, Adeyeoluwa, Temitayo Esther, additional, Adeyomoye, Olorunsola Israel, additional, Sakilah Adnani, Qorinah Estiningtyas, additional, Afrashteh, Fatemeh, additional, Afyouni, Shadi, additional, Afzal, Saira, additional, Agasthi, Pradyumna, additional, Agodi, Antonella, additional, Aguilera Arriagada, Constanza Elizabeth, additional, Agyemang-Duah, Williams, additional, Ahinkorah, Bright Opoku, additional, Ahmad, Aqeel, additional, Ahmad, Danish, additional, Ahmad, Firdos, additional, Ahmad, Muayyad M., additional, Ahmed, Ayman, additional, Ahmed, Haroon, additional, Ahmed, Muktar Beshir, additional, Ahmed, Syed Anees, additional, Ajami, Marjan, additional, Akinosoglou, Karolina, additional, Ala, Moein, additional, Ali AL-Ahdal, Tareq Mohammed, additional, Alalalmeh, Samer O., additional, Al-Aly, Ziyad, additional, Alam, Nazmul, additional, Al-amer, Rasmieh Mustafa, additional, Alashi, Alaa, additional, Albashtawy, Mohammed, additional, AlBataineh, Mohammad T., additional, Alema, Haileselasie Berhane, additional, Alemi, Sharifullah, additional, Alemu, Yihun Mulugeta, additional, Saeed Al-Gheethi, Adel Ali, additional, Alhabib, Khalid F., additional, Naji Alhalaiqa, Fadwa Alhalaiqa, additional, Ali, Mohammed Usman, additional, Ali, Rafat, additional, pursuing, PhD., additional, Shujait Ali, Syed Shujait, additional, Alicandro, Gianfranco, additional, Alikhani, Reyhaneh, additional, Aljunid, Syed Mohamed, additional, Alla, François, additional, Almahmeed, Wael, additional, Al-Marwani, Sabah, additional, Alonso, Jordi, additional, Al-Raddadi, Rajaa M., additional, Alvi, Farrukh Jawad, additional, Alvis-Guzman, Nelson, additional, Alvis-Zakzuk, Nelson J., additional, Alwafi, Hassan, additional, Aly, Hany, additional, Amegbor, Prince M., additional, Amin, Tarek Tawfik, additional, Amindarolzarbi, Alireza, additional, Amini-Rarani, Mostafa, additional, Amiri, Sohrab, additional, Ammirati, Enrico, additional, Anand, Tanu, additional, Ancuceanu, Robert, additional, Anderlini, Deanna, additional, Anil, Abhishek, additional, Ansari, Golnoosh, additional, Anyanwu, Philip Emeka, additional, Anyasodor, Anayochukwu Edward, additional, Carace Apostol, Geminn Louis, additional, Arabloo, Jalal, additional, Arafat, Mosab, additional, Aravkin, Aleksandr Y., additional, Aremu, Olatunde, additional, Armocida, Benedetta, additional, Ärnlöv, Johan, additional, Arowosegbe, Oluwaseyi Olalekan, additional, Artamonov, Anton A., additional, Artanti, Kurnia Dwi, additional, Arulappan, Judie, additional, Aruleba, Idowu Thomas, additional, Arumugam, Ashokan, additional, Aryan, Zahra, additional, Asghari-Jafarabadi, Mohammad, additional, Astell-Burt, Thomas, additional, Ataei, Mahshid, additional, Athar, Mohammad, additional, Atreya, Alok, additional, Aujayeb, Avinash, additional, Awotidebe, Adedapo Wasiu, additional, Aynalem, Amdehiwot A., additional, Azizi, Zahra, additional, Azzam, Ahmed Y., additional, Babu, Abraham Samuel, additional, Badar, Muhammad, additional, Bader, Feras, additional, Badiye, Ashish D., additional, Bagga, Arvind, additional, Bagherieh, Sara, additional, Asl, Farshad Bahrami, additional, Bai, Ruhai, additional, Baker, Jennifer L., additional, Bakkannavar, Shankar M., additional, Bako, Abdulaziz T., additional, Bakshi, Ravleen Kaur, additional, Balogun, Saliu A., additional, Baltatu, Ovidiu Constantin, additional, Bam, Kiran, additional, Banach, Maciej, additional, Bandyopadhyay, Soham, additional, Banik, Biswajit, additional, Chandra Banik, Palash, additional, Bansal, Kannu, additional, Baradaran, Hamid Reza, additional, Barbic, Franca, additional, Barchitta, Martina, additional, Bardhan, Mainak, additional, Barker-Collo, Suzanne Lyn, additional, Bärnighausen, Till Winfried, additional, Barone-Adesi, Francesco, additional, Barteit, Sandra, additional, Barua, Lingkan, additional, Bashiri, Azadeh, additional, Bayati, Mohsen, additional, Bayileyegn, Nebiyou Simegnew, additional, Behboudi, Emad, additional, Behnoush, Amir Hossein, additional, Béjot, Yannick, additional, Belay, Sefealem Assefa, additional, Belete, Melaku Ashagrie, additional, Belgaumi, Uzma Iqbal, additional, Bell, Michelle L., additional, Belo, Luis, additional, Bendak, Salaheddine, additional, Benfor, Bright, additional, Bennett, Derrick A., additional, Bensenor, Isabela M., additional, Benziger, Catherine P., additional, Beran, Azizullah, additional, Berman, Adam E., additional, Bermudez, Amiel Nazer C., additional, Bertolacci, Gregory J., additional, Beyene, Habtamu B., additional, Beyene, Kebede A., additional, Srikanth Bhagavathula, Akshaya Srikanth, additional, Bhardwaj, Nikha, additional, Bhardwaj, Pankaj, additional, Bhardwaj, Prarthna V., additional, Bhat, Vivek, additional, Bhatti, Gurjit Kaur, additional, Bhatti, Jasvinder Singh, additional, Bikbov, Boris, additional, Bikov, Andras, additional, Birck, Marina G., additional, Biswas, Bijit, additional, Bitaraf, Saeid, additional, Bodunrin, Aadam Olalekan, additional, Bogale, Eyob Ketema, additional, Bogale, Kassawmar Angaw, additional, Boloor, Archith, additional, Hashemi, Milad Bonakdar, additional, Borhany, Hamed, additional, Boyko, Edward J., additional, Braithwaite, Dejana, additional, Brant, Luisa C., additional, Brauer, Michael, additional, Breitner, Susanne, additional, Briko, Andrey, additional, Bulto, Lemma N., additional, Bustanji, Yasser, additional, Butt, Zahid A., additional, Calina, Daniela, additional, Cao, Fan, additional, Cárdenas, Rosario, additional, Carr, Sinclair, additional, Carreras, Giulia, additional, Carrero, Juan J., additional, Carvalho, Márcia, additional, Castaldelli-Maia, Joao Mauricio, additional, Castañeda-Orjuela, Carlos A., additional, Cattaruzza Luca Cegolon, Maria Sofia, additional, Cerin, Ester, additional, Chahine, Yaacoub, additional, Kai Chan, Jeffrey Shi, additional, Chan, Mei Yen, additional, Chan, Raymond N.C., additional, Charalampous, Periklis, additional, Charan, Jaykaran, additional, Chattu, Vijay Kumar, additional, Chen, An-Tian, additional, Chen, Catherine S., additional, Chen, Haowei, additional, Chennapragada, Suma Sri, additional, Chew, Derek S., additional, Chi, Gerald, additional, Ching, Patrick R., additional, Chitheer, Abdulaal, additional, Jemma Cho, So Mi, additional, Cho, William C.S., additional, Chong, Bryan, additional, Chopra, Hitesh, additional, Choudhary, Rahul, additional, Chowdhury, Enayet Karim, additional, Chowdhury, Rajiv, additional, Chu, Dinh-Toi, additional, Chukwu, Isaac Sunday, additional, Giuseppe Cicero, Arrigo Francesco, additional, Cindi, Zinhle, additional, Cioffi, Iolanda, additional, Coberly, Kaleb, additional, Coffey, Sean, additional, Columbus, Alyssa, additional, Conde, Joao, additional, Conti, Sara, additional, Corso, Barbara, additional, Cortés, Sandra, additional, Cortesi, Paolo Angelo, additional, Costa, Vera Marisa, additional, Couto, Rosa A.S., additional, Cowart, Emma Johnson, additional, Criqui, Michael H., additional, Cruz, Jessica A., additional, Dadana, Sriharsha, additional, Dadras, Omid, additional, Dai, Xiaochen, additional, Dai, Zhaoli, additional, Dalaba, Maxwell Ayindenaba, additional, Moura Damasceno, Albertino Antonio, additional, Damiani, Giovanni, additional, D'Amico, Emanuele, additional, Das, Saswati, additional, Das, Subasish, additional, Dashti, Mohsen, additional, Dashtkoohi, Mohammad, additional, Dastmardi, Maedeh, additional, Davletov, Kairat, additional, Debele, Aklilu Tamire, additional, Debopadhaya, Shayom, additional, DeCleene, Nicole K., additional, Delgado-Enciso, Ivan, additional, Delgado-Saborit, Juana Maria, additional, Demessa, Berecha Hundessa, additional, Demetriades, Andreas K., additional, Deng, Xinlei, additional, Denova-Gutiérrez, Edgar, additional, Dereje, Nebiyu Dereje, additional, Asrat Derese, Awoke Masrie, additional, Desai, Hardik Dineshbhai, additional, Desai, Rupak, additional, Chellaiyan Devanbu, Vinoth Gnana, additional, Rahman Dewan, Syed Masudur, additional, Dey, Sourav, additional, Dhulipala, Vishal R., additional, Diaz, Daniel, additional, Diaz, Michael J., additional, Ding, Delaney D., additional, Dinis-Oliveira, Ricardo Jorge, additional, Do, Thanh Chi, additional, Phuong Do, Thao Huynh, additional, Doaei, Saeid, additional, Dohare, Sushil, additional, Dong, Wanyue, additional, D'Oria, Mario, additional, Mombaque dos Santos, Wendel, additional, Douiri, Abdel, additional, Dowou, Robert Kokou, additional, Dsouza, Ashel Chelsea, additional, Dsouza, Haneil Larson, additional, Dsouza, Viola, additional, Du, Mi, additional, Duraes, Andre Rodrigues, additional, Durojaiye, Oyewole Christopher, additional, Dutta, Sulagna, additional, Dziedzic, Arkadiusz Marian, additional, Ebrahimi, Alireza, additional, Efendi, Defi, additional, Efendi, Ferry, additional, Effendi, Diyan Ermawan, additional, Eini, Ebrahim, additional, Ekholuenetale, Michael, additional, Ekundayo, Temitope Cyrus, additional, El Sayed, Iman, additional, El Tantawi, Maha, additional, Elbarazi, Iffat, additional, Elgar, Frank J., additional, Elgendy, Islam Y., additional, Elhadi, Muhammed, additional, El-Huneidi, Waseem, additional, Emamverdi, Mehdi, additional, Emeto, Theophilus I., additional, Erkhembayar, Ryenchindorj, additional, Eshetie, Tesfahun C., additional, Espinosa-Montero, Juan, additional, Etaee, Farshid, additional, Fabin, Natalia, additional, Fadhil, Ibtihal, additional, Fagbamigbe, Adeniyi Francis, additional, Falzone, Luca, additional, Sofia e Sá Farinha, Carla, additional, Faris, MoezAlIslam Ezzat Mahmoud, additional, Faro, Andre, additional, Faruque, Mithila, additional, Farwati, Medhat, additional, Fasanmi, Abidemi Omolara, additional, Fatehizadeh, Ali, additional, Fazeli, Pooria, additional, Feigin, Valery L., additional, Feng, Xiaoqi, additional, Fereshtehnejad, Seyed-Mohammad, additional, Feroze, Abdullah Hamid, additional, Ferrara, Pietro, additional, Ferreira, Nuno, additional, Filip, Irina, additional, Fleszar, Laura, additional, Flood, David, additional, Folayan, Morenike Oluwatoyin, additional, Fomenkov, Artem Alekseevich, additional, Fonseca, Diogo A., additional, Fornari, Carla, additional, Foschi, Matteo, additional, Franklin, Richard Charles, additional, Fukumoto, Takeshi, additional, BlimaFux, PhD., additional, Gaal, Peter Andras, additional, Gadanya, Muktar A., additional, Gaidhane, Shilpa, additional, Gaipov, Abduzhappar, additional, Gakidou, Emmanuela, additional, Galali, Yaseen, additional, Gallus, Silvano, additional, Gandhi, Aravind P., additional, Ganesan, Balasankar, additional, Gautam, Rupesh K., additional, Gebregergis, Miglas W.W., additional, Gebrekidan, Kahsu Gebrekirstos, additional, Geleijnse, Johanna M., additional, Gerema, Urge, additional, Ghajar, Alireza, additional, Ghamari, Seyyed-Hadi, additional, Ghasemi, MohammadReza, additional, Dabaghi, Ghazal Ghasempour, additional, Ghasemzadeh, Afsaneh, additional, Ghazy, Ramy Mohamed, additional, Gholamalizadeh, Maryam, additional, Ghuge, Arun Digambarrao, additional, Gill, Paramjit Singh, additional, Gill, Tiffany K., additional, Gillum, Richard F., additional, Gnedovskaya, Elena V., additional, Golchin, Ali, additional, Goleij, Pouya, additional, Gorini, Giuseppe, additional, Goulart, Alessandra C., additional, Goyal, Anmol, additional, Goyal, Kashish, additional, Guan, Shi-Yang, additional, Guarducci, Giovanni, additional, Gudeta, Mesay Dechasa, additional, Guha, Avirup, additional, Guicciardi, Stefano, additional, Gulisashvili, David, additional, Gunawardane, Damitha Asanga, additional, Guo, Cui, additional, Gupta, Anish Kumar, additional, Gupta, Bhawna, additional, Gupta, Indarchand Ratanlal, additional, Gupta, Kartik, additional, Gupta, Mohak, additional, Gupta, Rajat Das, additional, Gupta, Rajeev, additional, Gupta, Renu, additional, Gupta, Sapna, additional, Gupta, Veer Bala, additional, Gupta, Vijai Kumar, additional, Gupta, Vivek Kumar, additional, Gurmessa, Lami, additional, Gutiérrez, Reyna Alma, additional, Habibzadeh, Farrokh, additional, Hadei, Mostafa, additional, Haeri Boroojeni, Helia Sadat, additional, Halimi, Aram, additional, Haller, Sebastian, additional, Halwani, Rabih, additional, Hamadeh, Randah R., additional, Hamdy, Nadia M., additional, Hamidi, Samer, additional, Han, Chieh, additional, Han, Qiuxia, additional, Hankey, Graeme J., additional, Hannan, Md. Abdul, additional, Hargono, Arief, additional, Haro, Josep Maria, additional, Hasan, Faizul, additional, Hasan, Ikramul, additional, Hasani, Hamidreza, additional, Hashemian, Maryam, additional, Hasnain, Md Saquib, additional, Hassan, Amr, additional, Hassan, Ikrama, additional, Haubold, Johannes, additional, Havmoeller, Rasmus J., additional, Hay, Simon I., additional, Hayat, Khezar, additional, Hbid, Youssef, additional, Hegazi, Omar E., additional, Hegena, Tadele Yohannes, additional, Heidari, Mohammad, additional, Helfer, Bartosz, additional, Herrera-Serna, Brenda Yuliana, additional, Herteliu, Claudiu, additional, Hesami, Hamed, additional, Hessami, Kamran, additional, Heydari, Keyvan, additional, Hezam, Kamal, additional, Hiraike, Yuta, additional, Hoan, Nguyen Quoc, additional, Holla, Ramesh, additional, Hossain, Md Mahbub, additional, Hossain, Md. Belal, additional, Hosseinzadeh, Hassan, additional, Hosseinzadeh, Mehdi, additional, Hostiuc, Mihaela, additional, Hostiuc, Sorin, additional, Hsairi, Mohamed, additional, Huang, Junjie, additional, Hultström, Michael, additional, Huynh, Hong-Han, additional, Hwang, Bing-Fang, additional, Ibrahim, Khalid S., additional, Idowu, Oluwatope Olaniyi, additional, Ilesanmi, Olayinka Stephen, additional, Ilic, Irena M., additional, Ilic, Milena D., additional, Immurana, Mustapha, additional, Inbaraj, Leeberk Raja, additional, Iqhrammullah, Muhammad, additional, Shariful Islam, Sheikh Mohammed, additional, Ismail, Faisal, additional, Ismail, Nahlah Elkudssiah, additional, Isola, Gaetano, additional, Iwagami, Masao, additional, J, Linda Merin, additional, Jaafari, Jalil, additional, Jacob, Louis, additional, Jafarzadeh, Abdollah, additional, Jaggi, Khushleen, additional, Jahrami, Haitham, additional, Jain, Akhil, additional, Jain, Nityanand, additional, Jairoun, Ammar Abdulrahman, additional, Jakovljevic, Mihajlo, additional, Jamora, Roland Dominic G., additional, Javadi, Nilofer, additional, Jayapal, Sathish Kumar, additional, Jayaram, Shubha, additional, Jebai, Rime, additional, Jeben, Rebuma Sorsa, additional, Jee, Sun Ha, additional, Jha, Anil K., additional, Jha, Ravi Prakash, additional, Jha, Vivekanand, additional, Jiang, Heng, additional, Jin, Yinzi, additional, Jobanputra, Yash B., additional, Johnson, Catherine Owens, additional, Jokar, Mohammad, additional, Joo, Tamas, additional, Joseph, Abel, additional, Joseph, Nitin, additional, Joshua, Charity Ehimwenma, additional, Jozwiak, Jacek Jerzy, additional, Jürisson, Mikk, additional, Kabir, Ali, additional, Kabir, Zubair, additional, Kadashetti, Vidya, additional, Kahe, Farima, additional, Kalani, Rizwan, additional, Kalankesh, Laleh R., additional, Kalantar, Farnaz, additional, Kalkonde, Yogeshwar, additional, Kalra, Sanjay, additional, Kamath, Ashwin, additional, Kamath, Sagarika, additional, Kamireddy, Arun, additional, Kanchan, Tanuj, additional, Kandel, Himal, additional, Kanmanthareddy, Arun R., additional, Kanmodi, Kehinde Kazeem, additional, Kansal, Sushil Kumar, additional, Kapner, Daniel John, additional, Kar, Sitanshu Sekhar, additional, Karakasis, Paschalis, additional, Karki, Prabin, additional, Kashoo, Faizan Zaffar, additional, Kasraei, Hengameh, additional, Kassahun, Eskeziaw Abebe, additional, Kassebaum, Nicholas J., additional, Katoto, Patrick D.M. C., additional, Kaydi, Neda, additional, Kazemi, Foad, additional, Kazemian, Sina, additional, Kazeminia, Sara, additional, Kerr, Jessica A., additional, Kesse-Guyot, Emmanuelle, additional, Keykhaei, Mohammad, additional, Khadembashiri, Mohamad Mehdi, additional, Khadembashiri, Mohammad Amin, additional, Khafaie, Morteza Abdullatif, additional, Khajuria, Himanshu, additional, Khalaji, Amirmohammad, additional, Khalid, Nauman, additional, Khalilian, Alireza, additional, Khalilov, Rovshan, additional, Khan, Asaduzzaman, additional, Khan, Ejaz Ahmad, additional, Khan, Junaid, additional, Khan, M Nuruzzaman, additional, Khan, Maseer, additional, Khan, Mohammad Jobair, additional, Khan, Muhammad Shahzeb, additional, Khan, Yusra H., additional, Khan suheb, Mahammed Ziauddin, additional, Khanmohammadi, Shaghayegh, additional, Khatab, Khaled, additional, Khateri, Sorour, additional, Khayat Kashani, Hamid Reza, additional, Kheirallah, Khalid A., additional, Khidri, Feriha Fatima, additional, Kian, Saeid, additional, Kifle, Zemene Demelash, additional, Kimokoti, Ruth W., additional, Kisa, Adnan, additional, Kisa, Sezer, additional, Kolahi, Ali-Asghar, additional, Kompani, Farzad, additional, Koren, Gerbrand, additional, Kotnis, Ashwin Laxmikant, additional, Koul, Parvaiz A., additional, Koyanagi, Ai, additional, Krishan, Kewal, additional, Krishna, Hare, additional, Krishnamoorthy, Vijay, additional, Krishnamoorthy, Yuvaraj, additional, Kuddus, Md Abdul, additional, Kuddus, Mohammed, additional, Kulimbet, Mukhtar, additional, Kulkarni, Vishnutheertha, additional, Kumar, Akshay, additional, Kumar, Ashish, additional, Kumar, Naveen, additional, Kumar, Nithin, additional, Kumar, Rahul, additional, Kumsa, Netsanet Bogale, additional, Kunle, Kunle Rotimi, additional, Kusuma, Dian, additional, Kyriopoulos, Ilias, additional, La Vecchia, Carlo, additional, Lacey, Ben, additional, Ladan, Muhammad Awwal, additional, Laflamme, Lucie, additional, Lahariya, Chandrakant, additional, Lahiri, Arista, additional, Ching Lai, Daphne Teck, additional, Lallukka, Tea, additional, Lan, Qing, additional, Landires, Iván, additional, Lanfranchi, Francesco, additional, Larijani, Bagher, additional, Larsson, Anders O., additional, Lasrado, Savita, additional, Latief Epidemiology, Kamaluddin, additional, Latifinaibin, Kaveh, additional, Lau, Jerrald, additional, Lauriola, Paolo, additional, Le, Khuong, additional, Dao Le, Long Khanh, additional, Hanh Le, Nhi Huu, additional, Thu Le, Thao Thi, additional, Thanh Le, Trang Diep, additional, Bich Le, Trang Thi, additional, Ledda, Caterina, additional, Lee, Munjae, additional, Lee, Paul H., additional, Lee, Seung Won, additional, Lee, Wei-Chen, additional, Lee, Yo Han, additional, LeGrand, Kate E., additional, Leinsalu, Mall, additional, Leonardi, Matilde, additional, Lerango, Temesgen L., additional, Li, An, additional, Li, Ming-Chieh, additional, Li, Wei, additional, Li, Xiaopan, additional, Li, Yichong, additional, Lim, Lee-Ling, additional, Lim, Stephen S., additional, Lin, Ro-Ting, additional, Lindstrom, Megan, additional, Linn, Shai, additional, Liu, Gang, additional, Liu, Simin, additional, Liu, Xiaofeng, additional, Liu, Xuefeng, additional, Livingstone, Katherine M., additional, Llanaj, Erand, additional, Lopukhov, Platon D., additional, Sci (Med), Cand of, additional, Loreche, Arianna Maever, additional, Lorenzovici, László, additional, Lorkowski, Stefan, additional, Lotufo, Paulo A., additional, Lucchetti, Giancarlo, additional, Lugo, Alessandra, additional, Ma, Zheng Feei, additional, Madadizadeh, Farzan, additional, Maddison, Ralph, additional, Magaña Gómez, Javier A., additional, Magne, Julien, additional, Prasad, D. R. Mahadeshwara, additional, Mahalleh, Mehrdad, additional, Mahmoud, Mansour Adam, additional, Mahmoudi, Elham, additional, Mahmoudvand, Behnaz, additional, Makram, Omar Mohamed, additional, Rad, Elaheh Malakan, additional, Malekzadeh, Reza, additional, Malhotra, Kashish, additional, Malik, Iram, additional, Ahmed Malik, Muhammad Sajeel, additional, Mallhi, Tauqeer Hussain, additional, Malta, Deborah Carvalho, additional, Manilal, Aseer, additional, Manla, Yosef, additional, Mansoori, Yasaman, additional, Mansouri, Borhan, additional, Mansouri, Pejman, additional, Mansournia, Mohammad Ali, additional, Marateb, Hamid Reza, additional, Marino, Mirko, additional, Martini, Daniela, additional, Martini, Santi, additional, Maryam, Sharmeen, additional, Marzo, Roy Rillera, additional, Masoudi, Alireza, additional, Masoudi, Sahar, additional, Matei, Clara N., additional, Mathangasinghe, Yasith, additional, Mathews, Elezebeth, additional, Mathur, Manu Raj, additional, Mattumpuram, Jishanth, additional, Maude, Richard James, additional, Maugeri, Andrea, additional, Mayeli, Mahsa, additional, Mazidi, Mohsen, additional, McGrath, John J., additional, McPhail, Steven M., additional, Mechili, Enkeleint A., additional, Carabeo Medina, John Robert, additional, Meena, Jitendra Kumar, additional, Mehrabani-Zeinabad, Kamran, additional, Mendez Mendez-Lopez, Max Alberto, additional, Mendoza, Walter, additional, Menezes, Ritesh G., additional, Mengist, Belayneh, additional, Meo, Sultan Ayoub, additional, Meresa, Haftu Asmerom, additional, Meretoja, Atte, additional, Meretoja, Tuomo J., additional, Mestrovic, Tomislav, additional, Dinushi Mettananda, Kukulege Chamila, additional, Mettananda, Sachith, additional, Mhlanga, Laurette, additional, Mi, Tianyue, additional, Jonasson, Junmei Miao, additional, Miazgowski, Tomasz, additional, Michalek, Irmina Maria, additional, Miller, Ted R., additional, Nhat Minh, Le Huu, additional, Minja, Neema W., additional, Mohammad Sadeghi, Pouya Mir, additional, Mirdamadi, Niloofar, additional, Mirica, Andreea, additional, Mirrakhimov, Erkin M., additional, Mirza, Moonis, additional, Mirza-Aghazadeh-Attari, Mohammad, additional, Mithra, Prasanna, additional, Moghimi, Zahra, additional, Mohamed, Jama, additional, Mohamed, Mouhand F.H., additional, Mohamed, Nouh Saad, additional, Mohammadi, Soheil, additional, Mohammed, Hussen, additional, Mohammed, Mustapha, additional, Mohammed, Salahuddin, additional, Mohammed, Shafiu, additional, Moka, Nagabhishek, additional, Mokdad, Ali H., additional, Vardanjani, Hossein Molavi, additional, Momtazmanesh, Sara, additional, Monasta, Lorenzo, additional, Montazeri, Fateme, additional, Ghalibaf, AmirAli Moodi, additional, Moradi, Yousef, additional, Moraga, Paula, additional, Morawska, Lidia, additional, Morovatdar, Negar, additional, Morrison, Shane Douglas, additional, Morze, Jakub, additional, Mostafavi, Ebrahim, additional, Mostofinejad, Amirmahdi, additional, Mougin, Vincent, additional, Mousavi, Parsa, additional, Mousavi, Seyed Ehsan, additional, Mozaffarian, Dariush, additional, Msherghi, Ahmed, additional, Muccioli, Lorenzo, additional, Mueller, Ulrich Otto, additional, Mukherjee, Sumoni, additional, Munjal, Kavita, additional, Murillo-Zamora, Efrén, additional, Mustafa, Ghulam, additional, Muthu, Sathish, additional, Mwita, Julius C., additional, Myung, Woojae, additional, Nagarajan, Ahamarshan Jayaraman, additional, Nagaraju, Shankar Prasad, additional, Naik, Ganesh R., additional, Naik, Gurudatta, additional, Nair, Tapas Sadasivan, additional, Najafi, Mohammad Sadeq, additional, Ansari, Noureddin Nakhostin, additional, Nangia, Vinay, additional, Swamy, Sreenivas Narasimha, additional, Nargus, Shumaila, additional, Nascimento, Bruno Ramos, additional, Nascimento, Gustavo G., additional, Nasoori, Hadis, additional, Natto, Zuhair S., additional, Nauman, Javaid, additional, Naveed, Muhammad, additional, Nayak, Biswa Prakash, additional, Nayak, Vinod C., additional, Negash, Hadush, additional, Negoi, Ionut, additional, Negoi, Ruxandra Irina, additional, Shahrokh Abadi, Reza Nejad, additional, Nejadghaderi, Seyed Aria, additional, Nejjari, Chakib, additional, Nematollahi, Mohammad Hadi, additional, Nepal, Samata, additional, Ng, Nawi, additional, Nguyen, Dang H., additional, Nguyen, Phat Tuan, additional, Nguyen, Van Thanh, additional, Niazi, Robina Khan, additional, Nijjar, Shawn S., additional, Nizam, Muhammad A., additional, Noman, Efaq Ali, additional, Nomura, Shuhei, additional, Noreen, Mamoona, additional, Norrving, Bo, additional, Noubiap, Jean Jacques, additional, Nri-Ezedi, Chisom Adaobi, additional, Ntsekhe, Mpiko, additional, Nurrika, Dieta, additional, Nzoputam, Chimezie Igwegbe, additional, Nzoputam, Ogochukwu Janet, additional, Obamiro, Kehinde O., additional, O'Donnell, Martin James, additional, Oghenetega, Onome Bright, additional, Oguntade, Ayodipupo Sikiru, additional, Oguta, James Odhiambo, additional, Okeke, Sylvester Reuben, additional, Okekunle, Akinkunmi Paul, additional, Okidi, Lawrence, additional, Okonji, Osaretin Christabel, additional, Okwute, Patrick Godwin, additional, Olagunju, Andrew T., additional, Olaiya, Muideen Tunbosun, additional, Olana, Matifan Dereje, additional, Olatubi, Matthew Idowu, additional, Moraes Oliveira, Gláucia Maria, additional, Olorukooba, Abdulhakeem Abayomi, additional, Olufadewa, Isaac Iyinoluwa, additional, Oluwafemi, Yinka Doris, additional, Oluwatunase, Gideon Olamilekan, additional, Omer, Goran Latif, additional, Ommati, Mohammad Mehdi, additional, Ong, Kanyin Liane, additional, Ong, Sokking, additional, Onyedibe, Kenneth Ikenna, additional, Ordak, Michal, additional, Ortega-Altamirano, Doris V., additional, Ortiz, Alberto, additional, Ortiz-Prado, Esteban, additional, Osman, Wael M.S., additional, Osuagwu, Uchechukwu Levi, additional, Otoiu, Adrian, additional, Otstavnov, Stanislav S., additional, Owolabi, Mayowa O., additional, Padukudru P A, Mahesh, additional, Padron-Monedero, Alicia, additional, Padubidri, Jagadish Rao, additional, Varnosfaderani, Mahsa Pahlavikhah, additional, Palicz, Tamás, additional, Palladino, Raffaele, additional, Pan, Feng, additional, Pan, Hai-Feng, additional, Pandi-Perumal, Seithikurippu R., additional, Papadopoulou, Paraskevi, additional, Park, Seoyeon, additional, Passera, Roberto, additional, Patel, Jay, additional, Patil, Shankargouda, additional, Patoulias, Dimitrios, additional, Patthipati, Venkata Suresh, additional, Pawar, Shrikant, additional, Peden, Amy E., additional, Pedersini, Paolo, additional, Peng, Minjin, additional, Filipino Pepito, Veincent Christian, additional, Peprah, Emmanuel K., additional, Pereira, Marcos, additional, Pereira, Maria Odete, additional, Peres, Mario F.P., additional, Perianayagam, Arokiasamy, additional, Perico, Norberto, additional, Petermann-Rocha, Fanny Emily, additional, Pham, Hoang Tran, additional, Philip, Anil K., additional, Pigott, David M., additional, Pilgrim, Thomas, additional, Piradov, Michael A., additional, Plotnikov, Evgenii, additional, Poddighe, Dimitri, additional, Polibin, Roman V., additional, Poluru, Ramesh, additional, Pourali, Ghazaleh, additional, Pourshams, Akram, additional, Singh Pradhan, Pranil Man, additional, Prasad, Manya, additional, Sady Prates, Elton Junio, additional, Purohit, Bharathi M., additional, Puvvula, Jagadeesh, additional, Qattea, Ibrahim, additional, Qian, Gangzhen, additional, Qureshi, Maryam Faiz, additional, Rabiee rad, Mehrdad, additional, Radfar, Amir, additional, Rafiei Alavi, Seyedeh Niloufar, additional, Rafique, Ibrar, additional, Raggi, Alberto, additional, Rahim, Fakher, additional, Rahim, Md Jillur, additional, Rahimi, Mehran, additional, Rahman, Mosiur, additional, Rahman, Muhammad Aziz, additional, Rahmani, Amir Masoud, additional, Rahmani, Bita, additional, Rahmani, Shayan, additional, Rahmanian, Vahid, additional, Rai, Pramila, additional, Rajaa, Sathish, additional, Rajabpour-Sanati, Ali, additional, Rajput, Prashant, additional, Ram, Pradhum, additional, Ram, Prasanna, additional, Ramalingam, Sudha, additional, Ramasamy, Shakthi Kumaran, additional, Ramazanu, Sheena, additional, Ramesh, Pushkal Sinduvadi, additional, Rana, Juwel, additional, Rana, Kritika, additional, Ranabhat, Chhabi Lal, additional, Rancic, Nemanja, additional, Rane, Amey, additional, Ranjan, Shubham, additional, Ranta, Annemarei, additional, Rao, Indu Ramachandra, additional, Rao, Mithun, additional, Rao, Sowmya J., additional, Rashedi, Sina, additional, Rashedi, Vahid, additional, Rashid, Ahmed Mustafa, additional, Rasul, Azad, additional, Ratan, Zubair Ahmed, additional, Babu, Giridhara Rathnaiah, additional, Ravikumar, Nakul, additional, Rawaf, Salman, additional, Razeghian-Jahromi, Iman, additional, Razo, Christian, additional, Rama Krishna Reddy, Murali Mohan, additional, Mohamed Redwan, Elrashdy Moustafa, additional, Remuzzi, Giuseppe, additional, Reyes, Luis Felipe, additional, Rezaei, Nazila, additional, Rezaeian, Mohsen, additional, Ribeiro, Antonio Luiz P., additional, Ribeiro, Daniela, additional, Rikhtegar, Reza, additional, Roever, Leonardo, additional, Romadlon, Debby Syahru, additional, Ronfani, Luca, additional, Sekhar Rout, Himanshu Sehar, additional, Roy, Nitai, additional, Roy, Priyanka, additional, Rynkiewicz, Andrzej, additional, Saad, Aly M.A., additional, Saadatian, Zahra, additional, Sabour, Siamak, additional, Sacco, Simona, additional, Sachdeva, Rajesh, additional, Saddik, Basema, additional, Sadeghi, Erfan, additional, Saeed, Umar, additional, Safaeinejad, Fahimeh, additional, Sharif-Askari, Fatemeh Saheb, additional, Sharif-Askari, Narjes Saheb, additional, Sahebkar, Amirhossein, additional, Sahoo, Soumya Swaroop, additional, Sajedi, Seyed Aidin, additional, Sajid, Mirza Rizwan, additional, Sakshaug, Joseph W., additional, Salam, Nasir, additional, Salami, Afeez Abolarinwa, additional, Saleh, Mohamed A., additional, Salehi, Sana, additional, Salem, Marwa Rashad, additional, Salem, Mohammed Z.Y., additional, Samadzadeh, Sara, additional, Samargandy, Saad, additional, Samuel, Vijaya Paul, additional, Samy, Abdallah M., additional, Sanabria, Juan, additional, Sanjeev, Rama Krishna, additional, Santric-Milicevic, Milena M., additional, Nadeem Saqib, Muhammad Arif, additional, Sarasmita, Made Ary, additional, Saravanan, Aswini, additional, Sarikhani, Yaser, additional, Sarkar, Tanmay, additional, Sarmiento-Suárez, Rodrigo, additional, Sarode, Gargi Sachin, additional, Sarode, Sachin C., additional, Sathish, Thirunavukkarasu, additional, Sathyanarayan, Anudeep, additional, Sawhney, Monika, additional, Sayyah, Mehdi, additional, Scarmeas, Nikolaos, additional, Schaarschmidt, Benedikt Michael, additional, Schuermans, Art, additional, Schumacher, Austin E., additional, Schutte, Aletta Elisabeth, additional, Schwebel, David C., additional, Sedighi, Mansour, additional, Seidu, Abdul-Aziz, additional, Semnani, Farbod, additional, Senapati, Sabyasachi, additional, Sengupta, Pallav, additional, Senthilkumaran, Subramanian, additional, Sepanlou, Sadaf G., additional, Sethi, Yashendra, additional, Seyedi, Seyed Arsalan, additional, Seylani, Allen, additional, Shabany, Maryam, additional, Shafeghat, Melika, additional, Shafie, Mahan, additional, Shah, Pritik A., additional, Shahbandi, Ataollah, additional, Shahid, Izza, additional, Shahid, Samiah, additional, Shahid, Wajeehah, additional, Shahwan, Moyad Jamal, additional, Shaikh, Masood Ali, additional, Sham, Sunder, additional, Shamim, Muhammad Aaqib, additional, Shanawaz, Mohd, additional, Sharfaei, Sadaf, additional, Sharifan, Amin, additional, Sharifi-Rad, Javad, additional, Sharma, Purva, additional, Sharma, Saurab, additional, Sharma, Ujjawal, additional, Sharma, Vishal, additional, Sheikh, Aziz, additional, Shiferaw, Desalegn Shiferaw, additional, Shigematsu, Mika, additional, Shin, Min-Jeong, additional, Shiri, Rahman, additional, Shishani, Kawkab, additional, Shittu, Aminu, additional, Shiue, Ivy, additional, Shivakumar, K.M., additional, Shrestha, Sunil, additional, Shuval, Kerem, additional, Sibhat, Migbar Mekonnen, additional, Sigfusdottir, Inga Dora, additional, Simpson, Colin R., additional, Singh, Abhinav, additional, Singh, Aditya, additional, Singh, Ambrish, additional, Singh, Jasvinder A., additional, Singh, Paramdeep, additional, Singh, Rajat, additional, Singh, Surjit, additional, Siraj, Md Shahjahan, additional, Skryabin, Valentin Yurievich, additional, Skryabina, Anna Aleksandrovna, additional, Sleet, David A., additional, Soleimani, Hamidreza, additional, Solikhah, Solikhah, additional, Soliman, Sameh S.M., additional, Son, Juyeon, additional, Song, Suhang, additional, Song, Yi, additional, Soriano, Joan B., additional, Spartalis, Michael, additional, Sreeramareddy, Chandrashekhar T., additional, Stafford, Lauryn K., additional, Stark, Benjamin A., additional, Steiropoulos, Paschalis, additional, Stortecky, Stefan, additional, Abdulkader, Rizwan Suliankatchi, additional, Sultana, Abida, additional, Sundström, Johan, additional, Swain, Chandan Kumar, additional, Damavandi, Payam Tabaee, additional, Tabatabaei, Seyyed Mohammad, additional, Malazy, Ozra Tabatabaei, additional, Tabatabaeizadeh, Seyed-Amir, additional, Tabatabai, Shima, additional, Tabb, Karen M., additional, Tabish, Mohammad, additional, Tabuchi, Takahiro, additional, Tadese, Fentaw, additional, Abkenar, Yasaman Taheri, additional, Taiba, Jabeen, additional, Talaat, Iman M., additional, Tampa, Mircea, additional, Lukenze Tamuzi, Jacques J.L., additional, Tan, Ker-Kan, additional, Tang, Haosu, additional, Tarkang, Elvis Enowbeyang, additional, Tat, Nathan Y., additional, Tavangar, Seyed Mohammad, additional, Tehrani, Hadi, additional, Teimoori, Mojtaba, additional, Temsah, Mohamad-Hani, additional, Hani Temsah, Reem Mohamad, additional, Teramoto, Masayuki, additional, Thangaraju, Pugazhenthan, additional, Thankappan, Kavumpurathu Raman, additional, Thapa, Rajshree, additional, Thapar, Rekha, additional, Thavamani, Aravind, additional, Thayakaran, Rasiah, additional, Thomas, Nikhil Kenny, additional, Tian, Jing, additional, Tichopad, Ales, additional, Tillawi, Tala, additional, Tonelli, Marcello, additional, Topor-Madry, Roman, additional, Touvier, Mathilde, additional, Tovani-Palone, Marcos Roberto, additional, Tran, Jasmine T., additional, Tran, Nghia Minh, additional, Van Tran, Phu, additional, Trihandini, Indang, additional, Tripathi, Avnish, additional, Tromans, Samuel Joseph, additional, Truong, Vien T., additional, Tri Tai Truyen, Thien Tan, additional, Tsatsakis, Aristidis, additional, Tsegay, Guesh Mebrahtom, additional, Tsermpini, Evangelia Eirini, additional, Tumurkhuu, Munkhtuya, additional, Tung, Kang, additional, Ubah, Chukwudi S., additional, Udoakang, Aniefiok John, additional, Udoh, Arit, additional, Ullah, Atta, additional, Ullah, Sana, additional, Umair, Muhammad, additional, Umar, Tungki Pratama, additional, Unim, Brigid, additional, Unnikrishnan, Bhaskaran, additional, Upadhyay, Era, additional, Usman, Jibrin Sammani, additional, Vahabi, Seyed Mohammad, additional, Vaithinathan, Asokan Govindaraj, additional, Valizadeh, Rohollah, additional, Van den Eynde, Jef, additional, Varga, Orsolya, additional, Varma, Siddhartha Alluri, additional, Vart, Priya, additional, Varthya, Shoban Babu, additional, Vasankari, Tommi Juhani, additional, Vellingiri, Balachandar, additional, Vervoort, Dominique, additional, Villafañe, Jorge Hugo, additional, Violante, Francesco S., additional, Viskadourou, Maria, additional, Volovat, Simona Ruxandra, additional, Vos, Theo, additional, Vujcic, Isidora S., additional, Wafa, Hatem A., additional, Wahab, Feras, additional, Wang, Cong, additional, Wang, Fang, additional, Wang, Nelson, additional, Wang, Shu, additional, Wang, Yanzhong, additional, Wang, Yuan-Pang, additional, Wei, Melissa Y., additional, Werdecker, Andrea, additional, Wickramasinghe, Nuwan Darshana, additional, Wijeratne, Tissa, additional, Wilandika, Angga, additional, Wilson, Shadrach, additional, Wolfe, Charles D.A., additional, Wongsin, Utoomporn, additional, Wu, Zenghong, additional, Xiao, Hong, additional, Xu, Suowen, additional, Xu, Xiaoyue, additional, Yadav, Lalit, additional, Yano, Yuichiro, additional, Yaribeygi, Habib, additional, Yasufuku, Yuichi, additional, Nia, Iman Yazdani, additional, Ye, Pengpeng, additional, Yesuf, Subah Abderehim, additional, Yezli, Saber, additional, Yiğit, Arzu, additional, Yiğit, Vahit, additional, Yilma, Mekdes Tigistu, additional, Yon, Dong Keon, additional, Yonemoto, Naohiro, additional, Yousefi, Zabihollah, additional, Yperzeele, Laetitia, additional, Yu, Chuanhua, additional, Yunusa, Ismaeel, additional, Zafari, Nima, additional, Tajrishi, Farbod Zahedi, additional, Zakham, Fathiah, additional, Zastrozhin, Mikhail Sergeevich, additional, Zeineddine, Mohammad A., additional, Zemedikun, Dawit T., additional, Zeng, Youjie, additional, Zhai, Chunxia, additional, Zhang, Chen, additional, Zhang, Haijun, additional, Zhang, Hongwei, additional, Zhang, Liqun, additional, Zhang, Ning, additional, Zhang, Yunquan, additional, Zhao, Hanqing, additional, Zheng, Peng, additional, Zhong, Chenwen, additional, Zhou, Shuduo, additional, Zhu, Bin, additional, Zhu, Lei, additional, Zielińska, Magdalena, additional, Zikarg, Yossef Teshome, additional, Zmaili, Mohammad, additional, Zoeckler, Leo Zucker, additional, Zou, Zhiyong, additional, Zumla, Alimuddin, additional, Zweck, Elric, additional, and Zyoud, Samer H., additional

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2023
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23. Post-transplant recurrence of focal segmental glomerular sclerosis: consensus statements

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Raina, Rupesh, Jothi, Swathi, Haffner, Dieter, Somers, Michael, Filler, Guido, Vasistha, Prabhav, Chakraborty, Ronith, Shapiro, Ron, Randhawa, Parmjeet S., Parekh, Rulan, Licht, Christopher, Bunchman, Timothy, Sethi, Sidharth, Mangat, Guneive, Zaritsky, Joshua, Schaefer, Franz, Warady, Bradley, Bartosh, Sharon, McCulloch, Mignon, Alhasan, Khalid, Swiatecka-Urban, Agnieszka, Smoyer, William E., Chandraker, Anil, Yap, Hui Kim, Jha, Vivekanand, Bagga, Arvind, and Radhakrishnan, Jai

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2024
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29. Advillin acts upstream of phospholipase C [epsilon]1 in steroid-resistant nephrotic syndrome

Author

Rao, Jia, Ashraf, Shazia, Tan, Weizhen, van der Ven, Amelie T., Gee, Heon Yung, Braun, Daniela A., Feher, Krisztina, George, Sudeep P., Esmaeilniakooshkghazi, Amin, Choi, Won-Il, Jobst-Schwan, Tilman, Schneider, Ronen, Schmidt, Johanna Magdalena, Widmeier, Eugen, Warejko, Jillian K., Hermle, Tobias, Schapiro, David, Lovric, Svjetlana, Shril, Shirlee, Daga, Ankana, Nayir, Ahmet, Shenoy, Mohan, Tse, Yincent, Bald, Martin, Helmchen, Udo, Mir, Sevgi, Berdeli, Afig, Kari, Jameela A., Desoky, Sherif El, Soliman, Neveen A., Bagga, Arvind, Mane, Shrikant, Jairajpuri, Mohamad A., Lifton, Richard P., Khurana, Seema, Martins, Jose C., and Hildebrandt, Friedhelm

Subjects
Nephrotic syndrome -- Causes of -- Research, Cytoskeleton -- Research, Chronic kidney failure -- Genetic aspects, Health care industry
Abstract

Steroid-resistant nephrotic syndrome (SRNS) is a frequent cause of chronic kidney disease. Here, we identified recessive mutations in the gene encoding the actin-binding protein advillin (AVIL) in 3 unrelated families with SRNS. While all AVIL mutations resulted in a marked loss of its actin-bundling ability, truncation of AVIL also disrupted colocalization with F-actin, thereby leading to impaired actin binding and severing. Additionally, AVIL colocalized and interacted with the phospholipase enzyme PLCE1 and with the ARP2/3 actin-modulating complex. Knockdown of AVIL in human podocytes reduced actin stress fibers at the cell periphery, prevented recruitment of PLCE1 to the ARP3-rich lamellipodia, blocked EGF-induced generation of diacylglycerol (DAG) by PLCE1, and attenuated the podocyte migration rate (PMR). These effects were reversed by overexpression of WT AVIL but not by overexpression of any of the 3 patient-derived AVIL mutants. The PMR was increased by overexpression of WT Avilor PLCE1, or by EGF stimulation; however, this increased PMR was ameliorated by inhibition of the ARP2/3 complex, indicating that ARP-dependent lamellipodia formation occurs downstream of AVIL and PLCE1 function. Together, these results delineate a comprehensive pathogenic axis of SRNS that integrates loss of AVIL function with alterations in the action of PLCE1, an established SRNS protein., Introduction Nephrotic syndrome (NS) is characterized by proteinuria caused by disruption of the glomerular filtration barrier (1). It is the second most frequent cause of chronic kidney disease before the [...]

Published
2017
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31. PCRRT-ICONIC critical care pediatric nephrology course: the global prevalence of COVID-19 and associated sequelae

Author

Raina, Rupesh, primary, Vijayvargiya, Nina, additional, Kalra, Riti, additional, Yap, Hui-Kim, additional, Nair, Nikhil, additional, Alhasan, Khalid, additional, Montini, Giovanni, additional, Narang, Aarushi, additional, McCulloch, Mignon, additional, Bonilla-Felix, Melvin, additional, Bagga, Arvind, additional, Mok, Quen, additional, Tavares, Marcelo de Sousa, additional, Koch, Vera, additional, Schaefer, Franz, additional, Felipe, Cavagnaro, additional, Bunchman, Tim, additional, and Sethi, Sidharth, additional

Published
2022
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34. Sequential rituximab therapy sustains remission of nephrotic syndrome but carries high risk of adverse effects

Author

Sinha, Aditi, primary, Mathew, Georgie, additional, Arushi, Arushi, additional, Govindarajan, Srinivasavaradan, additional, Ghanapriya, Kshetrimayum, additional, Grewal, Neetu, additional, Rai, Khushboo, additional, Brijwal, Megha, additional, Kalluru, Sree Laya, additional, Tewari, Prachi, additional, Misra, Angeli, additional, Khandelwal, Priyanka, additional, Hari, Pankaj, additional, and Bagga, Arvind, additional

Published
2022
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35. Advillin acts upstream of phospholipase C ε1 in steroid-resistant nephrotic syndrome

Author

Rao, Jia, Ashraf, Shazia, Tan, Weizhen, van der Ven, Amelie T., Gee, Heon Yung, Braun, Daniela A., Fehér, Krisztina, George, Sudeep P., Esmaeilniakooshkghazi, Amin, Choi, Won-Il, Jobst-Schwan, Tilman, Schneider, Ronen, Schmidt, Johanna Magdalena, Widmeier, Eugen, Warejko, Jillian K., Hermle, Tobias, Schapiro, David, Lovric, Svjetlana, Shril, Shirlee, Daga, Ankana, Nayir, Ahmet, Shenoy, Mohan, Tse, Yincent, Bald, Martin, Helmchen, Udo, Mir, Sevgi, Berdeli, Afig, Kari, Jameela A., El Desoky, Sherif, Soliman, Neveen A., Bagga, Arvind, Mane, Shrikant, Jairajpuri, Mohamad A., Lifton, Richard P., Khurana, Seema, Martins, Jose C., and Hildebrandt, Friedhelm

Published
2017
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36. Sequential rituximab therapy sustains remission of nephrotic syndrome but carries high risk of adverse effects.

Author

Sinha, Aditi, Mathew, Georgie, Arushi, Arushi, Govindarajan, Srinivasavaradan, Ghanapriya, Kshetrimayum, Grewal, Neetu, Rai, Khushboo, Brijwal, Megha, Kalluru, Sree Laya, Tewari, Prachi, Misra, Angeli, Khandelwal, Priyanka, Hari, Pankaj, and Bagga, Arvind

Subjects
NEPHROTIC syndrome, BK virus, HEPATITIS B vaccines, RITUXIMAB, DISEASE remission, HEPATITIS B
Abstract

Background Sequential rituximab (RTX) administration has emerged as an important strategy to sustain remission of disease in patients with difficult-to-treat nephrotic syndrome. Methods We report the efficacy and safety of sequential therapy with two or more courses of intravenous RTX in 250 patients with difficult-to-treat steroid dependence (n  = 127) and calcineurin inhibitor (CNI)-dependent or CNI-refractory steroid resistance (n  = 123) managed at one center during 2015–2021. Subsets of patients were cross-sectionally tested for hypogammaglobulinemia, seroprotection against and hyporesponsiveness to vaccines for hepatitis B and tetanus, BK/JC viruria and human antichimeric antibodies (HACAs). Results Sequential RTX therapy, initiated at a median of 10 years [interquartile range (IQR) 7.3–14.4], was administered for 1.8 courses/person-year [95% confidence interval (CI) 1.7–2.0] over 2.0 years (95% CI 1.2–3.0). Therapy was associated with postponement of relapses by a median of 3 years in patients with steroid-sensitive disease and 2 years in those with steroid resistance. Relapses were reduced by a mean of 2.0 relapses/person-year (95% CI 1.8–2.2), enabling a reduction in prednisolone dose to 0.04 mg/kg/day (95% CI 0.01–0.11) and withdrawal of additional immunosuppression in 154 (62%) patients. RTX-associated adverse events, occurring at 0.20 events/person-year (95% CI 0.17–0.23), were chiefly comprised of infusion reactions (n  = 108) and infections (n  = 46); serious adverse events were observed in 10.8% patients, at 0.03 events/person-year (95% CI 0.02–0.05). Hypogammaglobulinemia was observed in 35% of 177 patients and was moderate to severe in 8.5% of cases. Rates of seroprotection at baseline and response following vaccination were lower for hepatitis B [1.9% and 29.4% (n  = 52)] than tetanus [65.5% and 34.5% (n  = 58)]. BK/JC viruria, without viremia, was observed in 7.3% of 109 cases. A total of 19 of 107 patients (17.8%) had HACAs, which were associated with B cell nondepletion and serum sickness. Age at therapy of <9–10 years was associated with a risk of early relapse, treatment failure and hypogammaglobulinemia following RTX therapy. Conclusions Sequential therapy with RTX effectively reduces relapses in patients with difficult-to-treat steroid- and/or CNI-dependent or CNI-refractory nephrotic syndrome. Therapy is associated with high rates of hypogammaglobulinemia and infusion reactions. [ABSTRACT FROM AUTHOR]

Published
2023
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38. IPNA clinical practice recommendations for the diagnosis and management of children with steroid-sensitive nephrotic syndrome

Author

Trautmann, Agnes, Boyer, Olivia, Hodson, Elisabeth, Bagga, Arvind, Gipson, Debbie S., Samuel, Susan, Wetzels, Jack, Alhasan, Khalid, Banerjee, Sushmita, Bhimma, Rajendra, Bonilla-Felix, Melvin, Cano, Francisco, Christian, Martin, Hahn, Deirdre, Kang, Hee Gyung, Nakanishi, Koichi, Safouh, Hesham, Trachtman, Howard, Xu, Hong, Cook, Wendy, Vivarelli, Marina, Haffner, Dieter, Bouts, Antonia, Dossier, Claire, Emma, Francesco, Kemper, Markus, Topaloglu, Rezan, Waters, Aoife, Thorsten Weber, Lutz, Zurowska, Alexandra, Gibson, Keisha L., Greenbaum, Larry, Massengill, Susan, Selewski, David, Srivastava, Tarak, Wang, Chia-shi, Wenderfer, Scott, Johnstone, Lilian, Larkins, Nicholas, Wong, William, Alba, Agnes A., Ha, T. S., Mokham, Masoumeh, Zhong, Xuhui, Hamada, Riku, Iijima, Kazumoto, Ishikura, Kenji, Nozu, Kandai, Bresolin, Nilzete, de Jesus Gonzalez, Nilka, Restrepo, Jaime, Anochie, Ifeoma, McCulloch, Mignon, Pediatrics, Paediatric Nephrology, ARD - Amsterdam Reproduction and Development, and AII - Amsterdam institute for Infection and Immunity

Subjects
Steroid-sensitive nephrotic syndrome, All institutes and research themes of the Radboud University Medical Center, Frequently relapsing nephrotic syndrome, Nephrology, Steroid toxicity, Pediatrics, Perinatology and Child Health, SSNS, Steroid-dependent nephrotic syndrome, Renal disorders Radboud Institute for Health Sciences [Radboudumc 11], Children, Pediatrics, Immunosuppressive treatment
Abstract

Contains fulltext : 290812.pdf (Publisher’s version ) (Open Access) Idiopathic nephrotic syndrome is the most frequent pediatric glomerular disease, affecting from 1.15 to 16.9 per 100,000 children per year globally. It is characterized by massive proteinuria, hypoalbuminemia, and/or concomitant edema. Approximately 85-90% of patients attain complete remission of proteinuria within 4-6 weeks of treatment with glucocorticoids, and therefore, have steroid-sensitive nephrotic syndrome (SSNS). Among those patients who are steroid sensitive, 70-80% will have at least one relapse during follow-up, and up to 50% of these patients will experience frequent relapses or become dependent on glucocorticoids to maintain remission. The dose and duration of steroid treatment to prolong time between relapses remains a subject of much debate, and patients continue to experience a high prevalence of steroid-related morbidity. Various steroid-sparing immunosuppressive drugs have been used in clinical practice; however, there is marked practice variation in the selection of these drugs and timing of their introduction during the course of the disease. Therefore, international evidence-based clinical practice recommendations (CPRs) are needed to guide clinical practice and reduce practice variation. The International Pediatric Nephrology Association (IPNA) convened a team of experts including pediatric nephrologists, an adult nephrologist, and a patient representative to develop comprehensive CPRs on the diagnosis and management of SSNS in children. After performing a systematic literature review on 12 clinically relevant PICO (Patient or Population covered, Intervention, Comparator, Outcome) questions, recommendations were formulated and formally graded at several virtual consensus meetings. New definitions for treatment outcomes to help guide change of therapy and recommendations for important research questions are given.

Published
2022

39. A Focus Group Study of Self-Management in Patients With Glomerular Disease

Author

Carter, Simon A. Teng, Claris Gutman, Talia Logeman, Charlotte Cattran, Dan Lightstone, Liz Bagga, Arvind and Barbour, Sean J. Barratt, Jonathan Boletis, John Caster, Dawn J. Coppo, Rosanna Fervenza, Fernando C. Floege, Jurgen and Hladunewich, Michelle A. Hogan, Jonathan J. Kitching, A. Richard Lafayette, Richard A. Malvar, Ana Radhakrishnan, Jai and Rovin, Brad H. Scholes-Robertson, Nicole Trimarchi, Hernan and Zhang, Hong Azukaitis, Karolis Cho, Yeoungjee Viecelli, Andrea K. Dunn, Louese Harris, David Johnson, David W. and Kerr, Peter G. Laboi, Paul Ryan, Jessica Shen, I, Jenny and Ruiz, Lorena Wang, Angela Yee-Moon Lee, Achilles Hoi Kan and Shun, Samuel Fung Ka Tong, Matthew Ka-Hang Teixeira-Pinto, Armando Wilkie, Martin Alexander, I, Stephen Craig, Jonathan C. Martin, Adam Tong, Allison

Abstract

Introduction: Patients with glomerular disease experience symptoms that impair their physical and mental health while managing their treatments, diet, appointments and monitoring general and specific indicators of health and their illness. We sought to describe the perspectives of patients and their care partners on self-management in glomerular disease. Methods: We conducted 16 focus groups involving adult patients with glomerular disease (n = 101) and their care partners (n = 34) in Australia, Hong Kong, the United Kingdom, and United States. Transcripts were analyzed thematically. Results: We identified the following 4 themes: empowered in autonomy (gaining confidence through understanding, taking ownership of disease and treatment, learning a positive health approach); over-whelmed by compounding treatment burdens (financially undermined and depleted, demoralized by side effects and harms, frustrated by fragmented and inflexible care, fear of possible drug harms); striving for stability and normalcy (making personal sacrifices, maximizing life participation, attentiveness to bodily signs, avoiding precarious health states, integrating medicines into routines); and necessity of health-sustaining relationships (buoyed by social support, fulfilling meaningful responsibilities, sharing and normalizing experiences, seeking a trusting and respectful alliance). Conclusion: Patients with glomerular disease and their care partners value their capacity for autonomy and disease ownership, stability of their health, and relationships that support self-management. Strategies directed at strengthening these factors may increase self-efficacy and improve the care and outcomes for patients with glomerular disease.

Published
2022

41. A Core Outcome Set for Trials in Glomerular Disease

Author

Carter, Simon A., primary, Lightstone, Liz, additional, Cattran, Dan, additional, Tong, Allison, additional, Bagga, Arvind, additional, Barbour, Sean J., additional, Barratt, Jonathan, additional, Boletis, John, additional, Caster, Dawn J., additional, Coppo, Rosanna, additional, Fervenza, Fernando C., additional, Floege, Jürgen, additional, Hladunewich, Michelle A., additional, Hogan, Jonathan J., additional, Kitching, A. Richard, additional, Lafayette, Richard A., additional, Malvar, Ana, additional, Radhakrishnan, Jai, additional, Rovin, Brad H., additional, Scholes-Robertson, Nicole, additional, Trimarchi, Hernán, additional, Zhang, Hong, additional, Anumudu, Samaya, additional, Cho, Yeoungjee, additional, Gutman, Talia, additional, O’Lone, Emma, additional, Viecelli, Andrea K., additional, Au, Eric, additional, Azukaitis, Karolis, additional, Baumgart, Amanda, additional, Bernier-Jean, Amelie, additional, Dunn, Louese, additional, Howell, Martin, additional, Ju, Angela, additional, Logeman, Charlotte, additional, Nataatmadja, Melissa, additional, Sautenet, Benedicte, additional, Sharma, Ankit, additional, and Craig, Jonathan C., additional

Published
2022
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42. Case reports

Author

Jagadisan, Barath, Krishnamurthy, Sriram, Raghavan, Renitha, Barathi, S. Deepak, Dhivyalakshmi, Jeevarathnam, Bhattacharyya, Shaila, Reddy, Rajeshwari, Arulselvi, K. I., Khandelwal, Priyanka, Sinha, Aditi, Hari, Pankaj, and Bagga, Arvind

Published
2014
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46. Defining renal remission in an international cohort of 248 children and adolescents with lupus nephritis

Author

De Mutiis, Chiara, primary, Wenderfer, Scott E, additional, Orjuela, Alvaro, additional, Bagga, Arvind, additional, Basu, Biswanath, additional, Sar, Tanmoy, additional, Aggarwal, Amita, additional, Jain, Avinash, additional, Yap, Hui-Kim, additional, Ito, Shuichi, additional, Ohnishi, Ai, additional, Iwata, Naomi, additional, Kasapcopur, Ozgur, additional, Laurent, Audrey, additional, Mastrangelo, Antonio, additional, Ogura, Masao, additional, Shima, Yuko, additional, Rianthavorn, Pornpimol, additional, Silva, Clovis A, additional, Trindade, Vitor, additional, Dormi, Ada, additional, and Tullus, Kjell, additional

Published
2021
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47. A Focus Group Study of Self-Management in Patients With Glomerular Disease

Author

Carter, Simon A., primary, Teng, Claris, additional, Gutman, Talia, additional, Logeman, Charlotte, additional, Cattran, Dan, additional, Lightstone, Liz, additional, Bagga, Arvind, additional, Barbour, Sean J., additional, Barratt, Jonathan, additional, Boletis, John, additional, Caster, Dawn J., additional, Coppo, Rosanna, additional, Fervenza, Fernando C., additional, Floege, Jürgen, additional, Hladunewich, Michelle A., additional, Hogan, Jonathan J., additional, Kitching, A. Richard, additional, Lafayette, Richard A., additional, Malvar, Ana, additional, Radhakrishnan, Jai, additional, Rovin, Brad H., additional, Scholes-Robertson, Nicole, additional, Trimarchi, Hernán, additional, Zhang, Hong, additional, Azukaitis, Karolis, additional, Cho, Yeoungjee, additional, Viecelli, Andrea K., additional, Dunn, Louese, additional, Harris, David, additional, Johnson, David W., additional, Kerr, Peter G., additional, Laboi, Paul, additional, Ryan, Jessica, additional, Shen, Jenny I., additional, Ruiz, Lorena, additional, Wang, Angela Yee-Moon, additional, Lee, Achilles Hoi Kan, additional, Ka Shun, Samuel Fung, additional, Ka-Hang Tong, Matthew, additional, Teixeira-Pinto, Armando, additional, Wilkie, Martin, additional, Alexander, Stephen I., additional, Craig, Jonathan C., additional, Martin, Adam, additional, and Tong, Allison, additional

Published
2021
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49. SARS-CoV-2 infection in children with nephrotic syndrome

Author

Krishnasamy, Sudarsan, Sinha, Aditi, and Bagga, Arvind

Subjects
Adult, Nephrotic Syndrome, SARS-CoV-2, Nephrology, Nephrosis, Lipoid, Pediatrics, Perinatology and Child Health, COVID-19, Humans, Child, Letter to the Editors, Pandemics
Abstract

Coronavirus Disease 2019 has spread from China as a global pandemic, Italy being one of the earliest affected countries. The infection displays a more complicated and often fatal course in adults with a history of kidney disease, while it does not seem to affect children in the same way. Pediatric patients with idiopathic nephrotic syndrome (INS), with or without chronic immunosuppressive therapy, are at greater risk of infections which may also trigger relapses.We performed a systematic review of the literature to identify all articles on SARS-CoV-2 infections in children with INS in order to describe the severity of all SARS-CoV-2 infections reported in children with INS, to evaluate the risk of new onset and relapses associated with SARS-CoV-2 infection, and to draw recommendations on their management and vaccination. The search was conducted on the following databases: MEDLINE (via Pubmed), Google Scholar, and Web of Science. The search methodology used with the selected free text terms or MesH was ("nephrotic syndrome" OR "idiopathic nephrotic syndrome") and ("covid 19" OR "severe acute respiratory syndrome coronavirus 2" OR "2019-nCoV" OR "SARS-CoV-2").The literature search provided 36 records. After screening for their relevance to the topic, 11 studies were selected. Two additional publications were identified through the reference list of all included articles and 13 articles were included in the review. A total of 43 cases of children with INS and SARS-CoV-2 infection have been reported; the course of the disease was mild for most patients with low need of respiratory support and no death in high income countries. In 5 patients, the infection was complicated by relapse, which anyway showed a good response to steroids. Two children had a new onset of INS during a SARS-CoV-2 infection.Children with INS, with or without immunosuppression, are not at higher risk of severe SARS-CoV-2 infection. Relapse is a possible complication, but steroid treatment is safe and effective. After summarizing the evidence, we have suggested recommendations for the management of children with INS during the pandemic and the vaccination campaign.

Published
2022

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