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7. ELTD1 as a multi-focal target for malignant gliomas: preclinical studies

Author

Zalles, Michelle, primary, Smith, Nataliya, additional, Saunders, Debra, additional, Guzman, Mayra, additional, Lerner, Megan, additional, Fung, Kar-Ming, additional, Babu, Anish, additional, Battiste, James, additional, Chung, Junho, additional, Hwang, Kyusang, additional, Jin, Junyeong, additional, and Towner, Rheal A, additional

Published
2021
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9. HuR Reduces Radiation-Induced DNA Damage by Enhancing Expression of ARID1A

Author

Andrade, Daniel, primary, Mehta, Meghna, additional, Griffith, James, additional, Oh, Sangphil, additional, Corbin, Joshua, additional, Babu, Anish, additional, De, Supriyo, additional, Chen, Allshine, additional, Zhao, Yan D., additional, Husain, Sanam, additional, Roy, Sudeshna, additional, Xu, Liang, additional, Aube, Jeffrey, additional, Janknecht, Ralf, additional, Gorospe, Myriam, additional, Herman, Terence, additional, Ramesh, Rajagopal, additional, and Munshi, Anupama, additional

Published
2019
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15. Nanosomes carrying doxorubicin exhibit potent anticancer activity against human lung cancer cells

Author

Srivastava, Akhil, primary, Amreddy, Narsireddy, additional, Babu, Anish, additional, Panneerselvam, Janani, additional, Mehta, Meghna, additional, Muralidharan, Ranganayaki, additional, Chen, Allshine, additional, Zhao, Yan Daniel, additional, Razaq, Mohammad, additional, Riedinger, Natascha, additional, Kim, Hogyoung, additional, Liu, Shaorong, additional, Wu, Si, additional, Abdel-Mageed, Asim B., additional, Munshi, Anupama, additional, and Ramesh, Rajagopal, additional

Published
2016
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16. HuR silencing elicits oxidative stress and DNA damage and sensitizes human triple-negative breast cancer cells to radiotherapy

Author

Mehta, Meghna, primary, Basalingappa, Kanthesh, additional, Griffith, James N., additional, Andrade, Daniel, additional, Babu, Anish, additional, Amreddy, Narsireddy, additional, Muralidharan, Ranganayaki, additional, Gorospe, Myriam, additional, Herman, Terence, additional, Ding, Wei-Qun, additional, Ramesh, Rajagopal, additional, and Munshi, Anupama, additional

Published
2016
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19. Nanoparticle-Based Drug Delivery for Therapy of Lung Cancer: Progress and Challenges

Author

Babu, Anish, Templeton, Amanda K., Munshi, Anupama, and Ramesh, Rajagopal

Subjects
Article Subject
Abstract

The last decade has witnessed enormous advances in the development and application of nanotechnology in cancer detection, diagnosis, and therapy culminating in the development of the nascent field of “cancer nanomedicine.” A nanoparticle as per the National Institutes of Health (NIH) guidelines is any material that is used in the formulation of a drug resulting in a final product smaller than 1 micron in size. Nanoparticle-based therapeutic systems have gained immense popularity due to their ability to overcome biological barriers, effectively deliver hydrophobic therapies, and preferentially target disease sites. Currently, many formulations of nanocarriers are utilized including lipid-based, polymeric and branched polymeric, metal-based, magnetic, and mesoporous silica. Innovative strategies have been employed to exploit the multicomponent, three-dimensional constructs imparting multifunctional capabilities. Engineering such designs allows simultaneous drug delivery of chemotherapeutics and anticancer gene therapies to site-specific targets. In lung cancer, nanoparticle-based therapeutics is paving the way in the diagnosis, imaging, screening, and treatment of primary and metastatic tumors. However, translating such advances from the bench to the bedside has been severely hampered by challenges encountered in the areas of pharmacology, toxicology, immunology, large-scale manufacturing, and regulatory issues. This review summarizes current progress and challenges in nanoparticle-based drug delivery systems, citing recent examples targeted at lung cancer treatment.

Published
2013
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20. Tumor-targeted and pH-controlled delivery of doxorubicin using gold nanorods for lung cancer therapy

Author

Amreddy,Narsireddy, Muralidharan,Ranganayaki, Babu,Anish, Mehta,Meghna, Johnson,Elyse V, Zhao,Yan D, Munshi,Anupama, Ramesh,Rajagopal, Amreddy,Narsireddy, Muralidharan,Ranganayaki, Babu,Anish, Mehta,Meghna, Johnson,Elyse V, Zhao,Yan D, Munshi,Anupama, and Ramesh,Rajagopal

Abstract

Narsireddy Amreddy,1,2 Ranganayaki Muralidharan,1,2 Anish Babu,1,2 Meghna Mehta,2,3 Elyse V Johnson,4 Yan D Zhao,2,5 Anupama Munshi,2,3 Rajagopal Ramesh1,2,6 1Department of Pathology, 2Stephenson Cancer Center, 3Department of Radiation Oncology University of Oklahoma Health Sciences Center, Oklahoma City, OK, USA; 4CytoViva Inc., Auburn, AL, USA; 5Department of Biostatistics and Epidemiology, 6Graduate Program in Biomedical Sciences, University of Oklahoma Health Sciences Center, Oklahoma City, OK, USA Background: In lung cancer, the efficacy of conventional chemotherapy is limited due to poor drug accumulation in tumors and nonspecific cytotoxicity. Resolving these issues will increase therapeutic efficacy.Methods: GNR-Dox-Tf-NPs (gold nanorod-doxorubicin-transferrin-nanoparticles) were prepared by different chemical approaches. The efficacy of these nanoparticles was carried out by cell viability in lung cancer and primary coronary artery smooth muscle cells. The receptor-mediated endocytosis studies were done with human transferrin and desferrioxamine preincubation. The GNR-Dox-Tf nanoparticles induced apoptosis, and DNA damage studies were done by Western blot, H2AX foci, and comet assay.Results: We developed and tested a gold nanorod-based multifunctional nanoparticle system (GNR-Dox-Tf-NP) that carries Dox conjugated to a pH-sensitive linker and is targeted to the transferrin receptor overexpressed in human lung cancer (A549, HCC827) cells. GNR-Dox-Tf-NP underwent physicochemical characterization, specificity assays, tumor uptake studies, and hyperspectral imaging. Biological studies demonstrated that transferrin receptor-mediated uptake of the GNR-Dox-Tf-NP by A549 and HCC827 cells produced increased DNA damage, apoptosis, and cell killing compared with nontargeted GNR-Dox-NP. GNR-Dox-Tf-NP-mediated cytotoxicity was greater (48% A549, 46% HCC827) than GNR-Dox-NP-mediated cytotoxicity (36% A549, 39% HCC827). Further, GNR-Dox-Tf-NP markedly reduced cytotoxicity

Published
2015

25. Cancer stem cells: progress and challenges in lung cancer.

Author

Templeton AK, Miyamoto S, Babu A, Munshi A, and Ramesh R

Abstract

The identification of a subpopulation of tumor cells with stem cell-like characteristics first in hematological malignancies and later in solid tumors has emerged into a novel field of cancer research. It has been proposed that this aberrant population of cells now called "cancer stem cells" (CSCs) drives tumor initiation, progression, metastasis, recurrence, and drug resistance. CSCs have been shown to have the capacity of self-renewal and multipotency. Adopting strategies from the field of stem cell research has aided in identification, localization, and targeting of CSCs in many tumors. Despite the huge progress in other solid tumors such as brain, breast, and colon cancers no substantial advancements have been made in lung cancer. This is most likely due to the current rudimentary understanding of lung stem cell hierarchy and heterogeneous nature of lung disease. In this review, we will discuss the most recent findings related to identification of normal lung stem cells and CSCs, pathways involved in regulating the development of CSCs, and the importance of the stem cell niche in development and maintenance of CSCs. Additionally, we will examine the development and feasibility of novel CSC-targeted therapeutic strategies aimed at eradicating lung CSCs.

Published
2014
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