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5. Experiments in a Parkinson's Rat Model

Author

Pallini, Roberto, Consales, Alessandro, Lauretti, Liverana, Fernandez, Eduardo, Choi-Lundberg, Derek L., and Bohn, Martha C.

Published
1997

6. Reconnection Rate and Long-Term Outcome with Adenosine Provocation During Cryoballoon Ablation for Pulmonary Vein Isolation

Author

Kaplan, Rachel M, primary, Dandamudi, Sanjay, additional, Bohn, Martha, additional, Verma, Nishant, additional, Tomson, Todd T, additional, Arora, Rishi, additional, Chicos, Alexandru B, additional, Goldberger, Jeffrey J, additional, Kim, Susan S, additional, Knight, Bradley P, additional, Lin, Albert C, additional, and Passman, Rod S, additional

Published
2017
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9. Onset of rosette formation during spontaneous neural differentiation of hESC and hiPSC colonies

Author

Malchenko, Sergey, primary, Xie, Jianping, additional, de Fatima Bonaldo, Maria, additional, Vanin, Elio F., additional, Bhattacharyya, Bula J., additional, Belmadani, Abdelhak, additional, Xi, Guifa, additional, Galat, Vasily, additional, Goossens, William, additional, Seftor, Richard E.B., additional, Tomita, Tadanori, additional, Crispino, John, additional, Miller, Richard J., additional, Bohn, Martha C., additional, Hendrix, Mary J.C., additional, and Soares, Marcelo B., additional

Published
2014
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10. POST-PROCEDURAL DABIGATRAN VERSUS STANDARD ANTICOAGULATION IN ABLATION FOR ATRIAL FIBRILLATION

Author

Lin, Jeffrey, primary, Knight, Bradley, additional, Bhave, Prashant, additional, Bohn, Martha, additional, Chicos, Alexandru, additional, Giedrimas, Evaldas, additional, Goldberger, Jeffrey, additional, Ilkhanoff, Leonard, additional, Kim, Susan, additional, Lin, Albert, additional, Patel, Taral, additional, Shen, Sharon, additional, and Passman, Rod, additional

Published
2013
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17. Human Fetal Astrocytes as an Ex VivoGene Therapy Vehicle for Delivering Biologically Active Nerve Growth Factor

Author

Lin, Qing, Cunningham, Lee A., Epstein, Leon G., Pechan, Peter A., Short, M. Priscilla, Fleet, Christina, and Bohn, Martha C.

Abstract

ABSTRACTThe therapeutic use of neurotrophic factors for neurodegenerative diseases is promising, however, optimal methods for continuous delivery of these substances to the human central nervous system (CNS) remains problematic. One approach would be to graft genetically engineered human cells that continuously secrete high levels of a biologically produced and processed neurotrophic factor. This ex vivogene therapy approach has worked well in animal models of neurodegenerative diseases using a variety of nonneuronal cell types to deliver the transgene. In our studies, we have been investigating the potential of astrocytes, a cell type normally present in the CNS, as a vehicle for ex vivogene therapy. Here, we demonstrate that astrocytes in the human fetal cortex can be isolated and efficiently infected with an amphotropic retrovirus harboring mouse -nerve growth factor (NGF). These transduced astrocytes express high levels of NGF mRNA and secrete bioactive NGF protein as demonstrated by stimulation of neurite outgrowth from adrenal chromaffin cells. NGF ELISA showed that these astrocytes secrete NGF protein at a rate of 41 ng/day per 105cells after 2 weeks in vitro, whereas NGF is undetectable in medium conditioned by normal astrocytes. These data suggest that human fetal astrocytes can be used for delivering biologically produced neurotrophic factors to the human CNS.

Published
1997
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19. Post-Procedural Dabigatran Versus Interrupted Warfarin Therapy Following Catheter Ablation for Atrial Fibrillation.

Author

Lin, Jeffrey, Shen, Sharon, Bhave, Prashant, Knight, Bradley, Bohn, Martha, Giedrimas, Evaldas, Patel, Taral K., Chicos, Alexandru, Goldberger, Jeffrey, Ilkhanoff, Leonard, Kim, Susan, Lin, Albert, and Passman, Rod

Subjects
*ATRIAL fibrillation treatment, *CATHETER ablation, *WARFARIN, *THROMBOSIS risk factors, *SURGICAL complications, *ANTICOAGULANTS
Abstract

Purpose:Patients undergoing catheter ablation for atrial fibrillation (AF) are at a higher risk of thromboembolic events post-procedure and therefore require therapeutic anticoagulation after ablation. Anticoagulation strategies include performing the procedure on or off therapeutic warfarin, though the latter approach requires post-procedure bridging therapy with low molecular-weight heparin (LMWH) until a therapeutic INR is achieved. The purpose of this study is to compare the safety and efficacy of post-ablation dabigatran as compared to warfarin with LMWH bridging. Methods: We performed a single-center retrospective analysis of consecutive patients who underwent catheter ablation for AF between January 2010 and December 2012 and received either post-procedure warfarin with a LMWH bridge or dabigatran. Warfarin was started the night of ablation; LMWH was started the next morning and continued until the INR was ⩾ 2.0. Dabigatran was started the morning post-ablation. Results: The analysis included 324 patients. Of these, mean age was 60 ± 9 years, 78% were male, 81% had CHADS2 scores of 0 or 1, and 181 (56%) received dabigatran post-ablation. Patients who received dabigatran had lower CHADS2 scores and were more likely to be in NYHA Class I. At 30-days post-procedure, there were 0 thromboembolic or bleeding complications in the dabigatran group versus 4 (2.8%) in the warfarin group (p=0.037). There were no deaths in either group at 30 days post-ablation. Conclusions: Post-ablation dabigatran appears safe and efficacious compared to an interrupted warfarin strategy with LMWH bridging. [ABSTRACT FROM AUTHOR]

Published
2014

21. 124. The “Perivascular Pump” Driven by Arterial Pulsation Is a Powerful Mechanism for the Distribution of Therapeutic Molecules within the Brain

Author

Hadaczek, Piotr, Mirek, Hanna, Tamas, Laszlo, Bohn, Martha C., Noble, Charles, Park, John W., and Bankiewicz, Krystof

Subjects
*MOLECULES, *BRAIN
Abstract

An abstract of the article "The Perivascular Pump Driven by Arterial Pulsation Is a Powerful Mechanism for the Distribution of Therapeutic Molecules within the Brain," by Piotr Hadaczek, Hanna Mirek, Laszlo Tamas, Martha C. Bohn, Charles Noble, John W. Park, and Krystof Bankiewicz is presented.

Published
2005
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