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1. Practical Consensus Guidelines for the Use of S-1 in GI Malignancies

Author

Purvish M Parikh, Tarini P. Sahoo, Ghanashyam Biswas, Vineet Talwar, Somashekhar SP, Soumya Surath Panda, Avinash CB, Nishita Shetty, Anita Ramesh, Joydeep Ghosh, Vijith Vital Shetty, Radheshyam Naik, Ashish Singh, Gaurav Gupta, and Bhavesh Parekh

Subjects
SCOPE-C, IASCO, Tegafur, OXO, CDHP, SAARC, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282
Published
2024
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2. Immunomodulatory Therapy in Head and Neck Squamous Cell Carcinoma: Recent Advances and Clinical Prospects

Author

Avinash Khadela PhD, Yesha Shah PharmD, Priya Mistry PharmD, Kunjan Bodiwala PhD, and Avinash CB DM

Subjects
Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282
Abstract

The immune system plays a significant role in the development, invasion, progression, and metastasis of head and neck cancer. Over the last decade, the emergence of immunotherapy has irreversibly altered the paradigm of cancer treatment. The current treatment modalities for head and neck squamous cell carcinoma (HNSCC) include surgery, radiotherapy, and adjuvant or neoadjuvant chemotherapy which has failed to provide satisfactory clinical outcomes. To encounter this, there is a need for a novel or targeted therapy such as immunological targets along with conventional treatment strategy for optimal therapeutic outcomes. The immune system can contribute to promoting metastasis, angiogenesis, and growth by exploiting the tumor's influence on the microenvironment. Immunological targets have been found effective in recent clinical studies and have shown promising results. This review outlines the important immunological targets and the medications acting on them that have already been explored, are currently under clinical trials and are further being targeted.

Published
2023
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3. A Multi- institutional Prospective Analysis of Impact of CanAssist Breast (Morphometric Immunohistochemistry Based Test) on Adjuvant Chemotherapy Decisions in Early Breast Cancer

Author

Karthik S Udapa, Ajay Bapna, Vijay Dg, Ravi Thippeswamy, Avinash Cb, Krishna Prasad, Shekhar Patil, Dinesh C. Doval, Rajeevkumar Rajeevkumar, Kiran Shankar, S.P. Somashekhar, and Chaturbhuj Agrawal

Subjects
Oncology, medicine.medical_specialty, business.industry, Adjuvant chemotherapy, fungi, food and beverages, Test (assessment), Prospective analysis, Text mining, Internal medicine, Medicine, Immunohistochemistry, business, Early breast cancer
Abstract

Purpose: CanAssist Breast (CAB) has been validated retrospectively for assessing risk of recurrence and thereby usefulness of chemotherapy in HR+/HER2- breast cancer. The objective of this study is to assess the agreement between physician’s treatment plan and CAB risk stratification and evaluate whether CAB results aid in the physician’s treatment decision.Methods: The data on the physician’s treatment plan before and after the CAB test was collected prospectively between 2016 and 2021 in 249 patients. Changes in treatment recommendations and compliance with CAB reports were analyzed. Results: Based on conventional clinicopathological features physicians planned to treat 46% of patients with endocrine therapy (ET) (low-risk-LR)), 24% with chemoendocrine therapy (CET) (high-risk-HR)) and in 30% physicians were uncertain of prescribing chemotherapy (intermediate-risk-IR)) before CAB testing. The correlation between clinical risk assessment and CAB risk stratification (k=0.2 (0.05-0.35) was nonsignificant. CAB classified 64% as LR, which was 18% (9.3-25, P=0.0001) higher compared to clinical LR. In the clinical IR category, CAB risk proportions were 55:45 (LR: HR). We observed a substantial shift in treatment recommendation from CET to ET in 54% (40.75- 66.84, PP

Published
2021
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