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104 results on '"Asano, Hiroyuki"'

1. Commissioning of a compact multibend achromat lattice: A new 3 GeV synchrotron radiation facility

Author

Obara, Shuhei, Ueshima, Kota, Asaka, Takao, Hosaka, Yuji, Kan, Koichi, Nishimori, Nobuyuki, Aoki, Toshitaka, Asano, Hiroyuki, Haga, Koichi, Iba, Yuto, Ihara, Akira, Ito, Katsumasa, Iwashita, Taiki, Kadowaki, Masaya, Kanahama, Rento, Kobayashi, Hajime, Kobayashi, Hideki, Nishihara, Hideo, Nishikawa, Masaaki, Oikawa, Haruhiko, Saida, Ryota, Sakuraba, Keisuke, Sugimoto, Kento, Suzuki, Masahiro, Takahashi, Kouki, Takahashi, Shunya, Tanaka, Tatsuki, Tsuchiyama, Tsubasa, Yoshioka, Risa, Aoki, Tsuyoshi, Dewa, Hideki, Fujita, Takahiro, Kawase, Morihiro, Kiyomich, Akio, Hamano, Takashi, Masaki, Mitsuhiro, Masuda, Takemasa, Matsubara, Shinichi, Okada, Kensuke, Saji, Choji, Taniuchi, Tsutomu, Taniuchi, Yukiko, Ueda, Yosuke, Yamaguchi, Hiroshi, Yanagida, Kenichi, Fukami, Kenji, Hosoda, Naoyasu, Ishii, Miho, Itoga, Toshiro, Iwai, Eito, Magome, Tamotsu, Oishi, Masaya, Ohshima, Takashi, Kondo, Chikara, Sakurai, Tatsuyuki, Shoji, Masazumi, Sugimoto, Takashi, Takano, Shiro, Tamura, Kazuhiro, Watanabe, Takahiro, Tomai, Takato, Azumi, Noriyoshi, Inagaki, Takahiro, Maesaka, Hirokazu, Takahashi, Sunao, Tanaka, Takashi, Inoue, Shinobu, Kumazawa, Hirosuke, Moriya, Kazuki, Sakai, Kohei, Seno, Toshio, Sumitomo, Hiroshi, Takesako, Ryoichi, Tanaka, Shinichiro, Yamamoto, Ryo, Yokomachi, Kazutoshi, Yoshioka, Masamichi, Hara, Toru, Matsui, Sakuo, Hiraiwa, Toshihiko, Tanaka, Hitoshi, and Ego, Hiroyasu

Subjects
Physics - Accelerator Physics, High Energy Physics - Experiment
Abstract

NanoTerasu, a new 3 GeV synchrotron light source in Japan, began user operation in April 2024. It provides high-brilliance soft to tender X-rays and covers a wide spectral range from ultraviolet to tender X-rays. Its compact storage ring with a circumference of 349 m is based on a four-bend achromat lattice to provide two straight sections in each cell for insertion devices with a natural horizontal emittance of 1.14 nm rad, which is small enough for soft X-rays users. The NanoTerasu accelerator incorporates several innovative technologies, including a full-energy injector C-band linear accelerator with a length of 110 m, an in-vacuum off-axis injection system, a four-bend achromat with B-Q combined bending magnets, and a TM020 mode accelerating cavity with built-in higher-order-mode dampers in the storage ring. This paper presents the accelerator machine commissioning over a half-year period and our model-consistent ring optics correction. The first user operation with a stored beam current of 160 mA is also reported. We summarize the storage ring parameters obtained from the commissioning. This is helpful for estimating the effective optical properties of synchrotron radiation at NanoTerasu., Comment: 30 pages, 24 figures, submitted to the journal

Published
2024

2. Communication-Aware Flight Algorithms for UAV-Based Delay-Tolerant Networks

Author

ASANO, Hiroyuki, OKADA, Hiraku, BEN NAILA, Chedlia, KATAYAMA, Masaaki, ASANO, Hiroyuki, OKADA, Hiraku, BEN NAILA, Chedlia, and KATAYAMA, Masaaki

Abstract

In this paper, a wireless communication network that uses unmanned aerial vehicles (UAVs) in the sky to transmit information between ground users is considered. We highlight a delay-tolerant network, where information is relayed in a store-and-forward fashion by establishing two types of intermittent communication links: between a UAV and a user (UAV-to-user) and between UAVs (UAV-to-UAV). Thus, a flight algorithm that controls the movement of the UAVs is crucial in achieving rapid information transmission. Our study proposes new flight algorithms that simultaneously consider the two types of communication links. In UAV-to-UAV links, the direct information transmission between two UAVs and the indirect transmission through other UAVs are considered separately. The movement of the UAVs is controlled by solving an optimization problem at certain time intervals, with a variable consideration ratio of the two types of links. In addition, we investigate not only the case where all UAVs move cooperatively but also the case where each UAV moves autonomously. Simulation results show that the proposed algorithms are effective. Moreover, they indicate the existence of an optimal consideration ratio of the two types of communication and demonstrate that our approach enables the control of frequencies of establishing the communication links. We conclude that increasing the frequency of indirect communication between UAVs improves network performance.

Published
2023

4. Rebounding Flight with Rebounding Rate in a Wireless Relay Network Using Drones

Author

ASANO, Hiroyuki, OKADA, Hiraku, BEN NAILA, Chedlia, and KATAYAMA, Masaaki

Subjects
無線リレーネットワーク, 臨時通信システム, ドローン, 飛行モデル
Abstract

広域災害被災地における臨時通信システムとして，ドローンを用いた無線リレーネットワークを考える．ドローンの飛行モデルである反発飛行について，どの程度離れた位置を目的地とするかを決める反発率を導入し，反発率を変化させた場合の遅延特性を評価する

Published
2020

8. Supplemental Material, sj-docx-1-tpx-10.1177_01926233211027474 - Chimeric Mouse With Humanized Liver Is an Appropriate Animal Model to Investigate Mode of Action for Porphyria-Mediated Hepatocytotoxicity

Author

Eguchi, Ayumi, Fukunaga, Satoki, Ogata, Keiko, Kushida, Masahiko, Asano, Hiroyuki, Cohen, Samuel M., and Sukata, Tokuo

Subjects
FOS: Clinical medicine, 111599 Pharmacology and Pharmaceutical Sciences not elsewhere classified
Abstract

Supplemental Material, sj-docx-1-tpx-10.1177_01926233211027474 for Chimeric Mouse With Humanized Liver Is an Appropriate Animal Model to Investigate Mode of Action for Porphyria-Mediated Hepatocytotoxicity by Ayumi Eguchi, Satoki Fukunaga, Keiko Ogata, Masahiko Kushida, Hiroyuki Asano, Samuel M. Cohen and Tokuo Sukata in Toxicologic Pathology

Published
2021
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15. 「Jo Kleyと学生たちの国際彫刻シンポジウム2013」の考察

Author

ASANO,Hiroyuki, TAKAHASHI,Kiharu, ARAKAWA,Shinichirou, KURODA,Chihiro, ITAGAKI,Daichi, 高橋,来春(東京学芸大学Ｂ類美術専攻 平成24年度卒), 荒川,新一郎(東京学芸大学Ａ類美術専修 平成24年度卒), 黒田,千紘(東京学芸大学Ａ類美術専修 平成25年度卒), and 板垣,大地(東京学芸大学Ｇ類美術専攻4年)

Subjects
ETYP:教育実践, Sculpture Symposium, STYP:大学, SSUB:美術
Published
2014

18. Mapping the genetic diversity of HLA haplotypes in the Japanese populations

Author

Saw, Woei Yuh, Liu, Xuanyao, Khor, Chiea Chuen, Takeuchi, Fumihiko, Katsuya, Tomohiro, Kimura, Ryosuke, Nabika, Toru, Ohkubo, Takayoshi, Tabara, Yasuharu, Yamamoto, Ken, Yokota, Mitsuhiro, Akiyama, Koichi, Asano, Hiroyuki, Asayama, Kei, Haga, Toshikazu, Hara, Azusa, Hirose, Takuo, Hosaka, Miki, Ichihara, Sahoko, Imai, Yutaka, Inoue, Ryusuke, Ishiguro, Aya, Isomura, Minoru, Isono, Masato, Kamide, Kei, Kato, Norihiro, Kikuya, Masahiro, Kohara, Katsuhiko, Matsubara, Tatsuaki, Matsuda, Ayako, Metoki, Hirohito, Miki, Tetsuro, Murakami, Keiko, Nakatochi, Masahiro, Ogihara, Toshio, Ohnaka, Keizo, Rakugi, Hiromi, Satoh, Michihiro, Shiwaku, Kunihiro, Sugimoto, Ken, Takami, Yoichi, Takayanagi, Ryoichi, Tsubota-Utsugi, Megumi, Yamamoto, Koichi, Yamasaki, Masayuki, Yasui, Daisaku, and Teo, Yik Ying

Abstract

Japan has often been viewed as an Asian country that possesses a genetically homogenous community. The basis for partitioning the country into prefectures has largely been geographical, although cultural and linguistic differences still exist between some of the districts/prefectures, especially between Okinawa and the mainland prefectures. The Major Histocompatibility Complex (MHC) region has consistently emerged as the most polymorphic region in the human genome, harbouring numerous biologically important variants; nevertheless the presence of population-specific long haplotypes hinders the imputation of SNPs and classical HLA alleles. Here, we examined the extent of genetic variation at the MHC between eight Japanese populations sampled from Okinawa, and six other prefectures located in or close to the mainland of Japan, specifically focusing at the haplotypes observed within each population, and what the impact of any variation has on imputation. Our results indicated that Okinawa was genetically farther to the mainland Japanese than were Gujarati Indians from Tamil Indians, while the mainland Japanese from six prefectures were more homogeneous than between northern and southern Han Chinese. The distribution of haplotypes across Japan was similar, although imputation was most accurate for Okinawa and several mainland prefectures when population-specific panels were used as reference.

Published
2015

21. Mapping the genetic diversity of HLA haplotypes in the Japanese populations

Author

00268749, Saw, Woei Yuh, Liu, Xuanyao, Khor, Chiea Chuen, Takeuchi, Fumihiko, Katsuya, Tomohiro, Kimura, Ryosuke, Nabika, Toru, Ohkubo, Takayoshi, Tabara, Yasuharu, Yamamoto, Ken, Yokota, Mitsuhiro, Akiyama, Koichi, Asano, Hiroyuki, Asayama, Kei, Haga, Toshikazu, Hara, Azusa, Hirose, Takuo, Hosaka, Miki, Ichihara, Sahoko, Imai, Yutaka, Inoue, Ryusuke, Ishiguro, Aya, Isomura, Minoru, Isono, Masato, Kamide, Kei, Kato, Norihiro, Kikuya, Masahiro, Kohara, Katsuhiko, Matsubara, Tatsuaki, Matsuda, Ayako, Metoki, Hirohito, Miki, Tetsuro, Murakami, Keiko, Nakatochi, Masahiro, Ogihara, Toshio, Ohnaka, Keizo, Rakugi, Hiromi, Satoh, Michihiro, Shiwaku, Kunihiro, Sugimoto, Ken, Takami, Yoichi, Takayanagi, Ryoichi, Tsubota-Utsugi, Megumi, Yamamoto, Koichi, Yamasaki, Masayuki, Yasui, Daisaku, Teo, Yik Ying, 00268749, Saw, Woei Yuh, Liu, Xuanyao, Khor, Chiea Chuen, Takeuchi, Fumihiko, Katsuya, Tomohiro, Kimura, Ryosuke, Nabika, Toru, Ohkubo, Takayoshi, Tabara, Yasuharu, Yamamoto, Ken, Yokota, Mitsuhiro, Akiyama, Koichi, Asano, Hiroyuki, Asayama, Kei, Haga, Toshikazu, Hara, Azusa, Hirose, Takuo, Hosaka, Miki, Ichihara, Sahoko, Imai, Yutaka, Inoue, Ryusuke, Ishiguro, Aya, Isomura, Minoru, Isono, Masato, Kamide, Kei, Kato, Norihiro, Kikuya, Masahiro, Kohara, Katsuhiko, Matsubara, Tatsuaki, Matsuda, Ayako, Metoki, Hirohito, Miki, Tetsuro, Murakami, Keiko, Nakatochi, Masahiro, Ogihara, Toshio, Ohnaka, Keizo, Rakugi, Hiromi, Satoh, Michihiro, Shiwaku, Kunihiro, Sugimoto, Ken, Takami, Yoichi, Takayanagi, Ryoichi, Tsubota-Utsugi, Megumi, Yamamoto, Koichi, Yamasaki, Masayuki, Yasui, Daisaku, and Teo, Yik Ying

Abstract

Japan has often been viewed as an Asian country that possesses a genetically homogenous community. The basis for partitioning the country into prefectures has largely been geographical, although cultural and linguistic differences still exist between some of the districts/prefectures, especially between Okinawa and the mainland prefectures. The Major Histocompatibility Complex (MHC) region has consistently emerged as the most polymorphic region in the human genome, harbouring numerous biologically important variants; nevertheless the presence of population-specific long haplotypes hinders the imputation of SNPs and classical HLA alleles. Here, we examined the extent of genetic variation at the MHC between eight Japanese populations sampled from Okinawa, and six other prefectures located in or close to the mainland of Japan, specifically focusing at the haplotypes observed within each population, and what the impact of any variation has on imputation. Our results indicated that Okinawa was genetically farther to the mainland Japanese than were Gujarati Indians from Tamil Indians, while the mainland Japanese from six prefectures were more homogeneous than between northern and southern Han Chinese. The distribution of haplotypes across Japan was similar, although imputation was most accurate for Okinawa and several mainland prefectures when population-specific panels were used as reference.

Published
2015

22. J-PARCリニアックにおける高周波負水素イオン源の状況

Author

Oguri, Hidetomo, Okoshi, Kiyonori, Ikegami, Kiyoshi, Takagi, Akira, Asano, Hiroyuki, Ueno, Akira, and Shibata, Takanori

Abstract

For the upgrade of the Japan Proton Accelerator Research Complex (J-PARC) linac beam current, a cesiated RF-driven negative hydrogen ion source was installed in 2014 summer shutdown period, and started to operate on September 29, 2014. The ion source has been successfully operated with a beam current and a duty factor of 33 mA and 1.25\% (0.5 ms and 25 Hz), respectively. The result of recent beam operation showed that the ion source is capable of continuous operation for approximately 1,100 h. The spark rate at the beam extractor was observed to be less than once a day, which is acceptable level for the user operation. Although the antenna failure occurred during the user operation on October 26, 2014, there were no further serious troubles since then. In this conference, we will present the some operation parameters and the beam stability of the RF-driven ion source through the long-term user operation., J-PARCリニアックのビーム電流を増強するために、セシウム添加型高周波負水素イオン源を2014年夏の加速器メンテナンス時にインストールし、同年9月29日より運転を開始した。現在、本イオン源はビーム電流33mA、デューティファクタ1.25\%で稼働している。いままでのところ、連続運転時間は約1100時間を達成している。運転中の高圧部放電頻度は1日に1回以下であり、ユーザ運転には影響のないレベルである。2014年10月にアンテナが破損したが、それ以降は深刻なトラブルは発生していない。本会議では、本イオン源の長時間運転における各種パラメータや安定性について発表する。

Published
2016

23. Numerical study of plasma generation process and internal antenna heat loadings in J-PARC RF negative ion source

Author

Shibata, Takanori, Nishida, Kenjiro, Mochizuki, Shintaro, Mattei, S., Lettry, J., Hatayama, Akiyoshi, Ueno, Akira, Oguri, Hidetomo, Okoshi, Kiyonori, Ikegami, Kiyoshi, Takagi, Akira, Asano, Hiroyuki, and Naito, Fujio

Subjects
Physics::Plasma Physics
Abstract

A numerical model of plasma transport and electromagnetic field in the J-PARC RF ion source has been developed to understand relation between antenna coil heat loadings and plasma production/transport processes. From the calculation, the local plasma density increase is observed in the region close to the antenna coil. The magnetic field line with absolute magnetic flux density 30-120 Gauss results in the magnetization of electron which leads to high local ionization rate. The results suggest that modification of magnetic configuration can be made to reduce plasma heat flux onto the antenna., J-PARC高周波(RF)イオン源のアンテナコイル熱負荷とプラズマ熱流束の関係を明らかにするため、プラズマ輸送過程と電磁場分布を同時に解析する数値シミュレーションモデルを構築した。シミュレーションから、ロッドフィルターおよびカスプ磁石により、アンテナコイル近傍で、磁束密度の絶対値が30-120Gaussの値を取る領域が生じる。このような磁場中では、イオン源内の電子が磁化されるため、コイル近傍で電子密度増加が起こる。すると、水素分子・原子のイオン化が促進されるため、局在的にプラズマ密度が増加する。このとき、アンテナ電位が負の値を取ると、イオン化で生じた水素の正イオンがアンテナに向かって加速され、アンテナの特定部位に熱負荷が集中する結果が得られた。これより、フィルター、およびカスプ磁石の配置変更により、コイル近傍の磁場構造を改変することで、熱負荷が低減されることが指摘された。

Published
2016

24. Fine-tuning to minimize emittances of J-PARC RF-driven H^- ion source

Author

Ueno, Akira, Okoshi, Kiyonori, Ikegami, Kiyoshi, Takagi, Akira, Asano, Hiroyuki, and Oguri, Hidetomo

Subjects
Physics::Accelerator Physics
Abstract

The Japan Proton Accelerator Research Complex (J-PARC) cesiated rf-driven H$^-$ ion source (IS), whose requirements are a peak beam intensity of 60mA within normalized emittances of 1.5 $\pi$mm$\cdot$mrad both horizontally and vertically, a flat top beam duty factor of 1.25\% (500 $\mu$s$ \times$ 25 Hz) and a life-time of longer than 1month, has been successfully operated for about one year. The results of the fine-tuning to minimize the emittances of the J-PARC-IS with plasma chamber \#3, which had the largest emittances with initial settings among four plasma chambers, will be presented in this paper. The rod-filter-filed will be finely tuned by selecting magnets with slightly different field strengths and/or changing gap-lengths. The dependence of the beam-hole-diameter on the emittances will be also presented. The tuning procedure to improve the emittances is one of the most important technologies for the IS of the high-energy and high-intensity accelerator., J-PARCセシウム添加高周波駆動負水素イオン源は、約1年間運転に使用されてきた。このイオン源への要求性能は、水平と垂直両方向エミッタンス1.5$\pi$mm$\cdot$mrad内にピークビーム強度60mA、強度一定のビームデューティ1.25\%(500$\mu$s$\times$25Hz)と1ヶ月以上の寿命である。プラズマ容器\#3を使用したエミッタンスを最小にするための微細調整の結果を報告する。初期設定時のプラズマ容器\#3のエミッタンスは、4つの同型プラズマ容器の中で、最も大きかった。わずかに異なる磁場強度を有する永久磁石の選定や磁石間ギャップ長の調整によるロッドフィルター磁場の微細調整や引き出し電極孔径の違いによるエミッタンスの測定結果を報告する。エミッタンス改善のために調整手順は、高強度高エネルギー加速器用イオン源にとって最も重要な技術の一つである。

Published
2016

26. 「Jo Kleyと学生たちの国際彫刻シンポジウム2013」の考察

Author

朝野,浩行, 高橋,来春, 荒川,新一郎, 黒田,千紘, 板垣,大地, ASANO,Hiroyuki, TAKAHASHI,Kiharu, ARAKAWA,Shinichirou, KURODA,Chihiro, ITAGAKI,Daichi, 朝野,浩行(東京学芸大学美術分野), 高橋,来春(東京学芸大学Ｂ類美術専攻 平成24年度卒), 荒川,新一郎(東京学芸大学Ａ類美術専修 平成24年度卒), 黒田,千紘(東京学芸大学Ａ類美術専修 平成25年度卒), 板垣,大地(東京学芸大学Ｇ類美術専攻4年), 朝野,浩行, 高橋,来春, 荒川,新一郎, 黒田,千紘, 板垣,大地, ASANO,Hiroyuki, TAKAHASHI,Kiharu, ARAKAWA,Shinichirou, KURODA,Chihiro, ITAGAKI,Daichi, 朝野,浩行(東京学芸大学美術分野), 高橋,来春(東京学芸大学Ｂ類美術専攻 平成24年度卒), 荒川,新一郎(東京学芸大学Ａ類美術専修 平成24年度卒), 黒田,千紘(東京学芸大学Ａ類美術専修 平成25年度卒), and 板垣,大地(東京学芸大学Ｇ類美術専攻4年)

Published
2014

29. Genome-wide association study of coronary artery disease in the Japanese

Author

Takeuchi Fumihiko, Yokota Mitsuhiro, Yamamoto Ken, Nakashima Eitaro, Katsuya Tomohiro, Asano Hiroyuki, Isono Masato, Nabika, Toru, Sugiyama Takao, Fujioka Akihiro, Awata Nobuhisa, Ohnaka Keizo, Nakatochi Masahiro, Kitajima Hidetoshi, Rakugi Hiromi, Nakamura Jiro, Ohkubo Takayoshi, Imai Yutaka, Shimamoto Kazuaki, Yamori Yukio, Yamaguchi Shuhei, Kobayashi Shotai, Takayanagi Ryoichi, Ogihara Toshio, Kato Norihiro, Takeuchi Fumihiko, Yokota Mitsuhiro, Yamamoto Ken, Nakashima Eitaro, Katsuya Tomohiro, Asano Hiroyuki, Isono Masato, Nabika, Toru, Sugiyama Takao, Fujioka Akihiro, Awata Nobuhisa, Ohnaka Keizo, Nakatochi Masahiro, Kitajima Hidetoshi, Rakugi Hiromi, Nakamura Jiro, Ohkubo Takayoshi, Imai Yutaka, Shimamoto Kazuaki, Yamori Yukio, Yamaguchi Shuhei, Kobayashi Shotai, Takayanagi Ryoichi, Ogihara Toshio, and Kato Norihiro

Published
2012

30. A genome-wide association study of a coronary artery disease risk variant

Author

Lee, Ji-Young, primary, Lee, Bok-Soo, additional, Shin, Dong-Jik, additional, Woo Park, Kyung, additional, Shin, Young-Ah, additional, Joong Kim, Kwang, additional, Heo, Lyong, additional, Young Lee, Ji, additional, Kyoung Kim, Yun, additional, Jin Kim, Young, additional, Bum Hong, Chang, additional, Lee, Sang-Hak, additional, Yoon, Dankyu, additional, Jung Ku, Hyo, additional, Oh, Il-Young, additional, Kim, Bong-Jo, additional, Lee, Juyoung, additional, Park, Seon-Joo, additional, Kim, Jimin, additional, Kawk, Hye-kyung, additional, Lee, Jong-Eun, additional, Park, Hye-kyung, additional, Lee, Jae-Eun, additional, Nam, Hye-young, additional, Park, Hyun-young, additional, Shin, Chol, additional, Yokota, Mitsuhiro, additional, Asano, Hiroyuki, additional, Nakatochi, Masahiro, additional, Matsubara, Tatsuaki, additional, Kitajima, Hidetoshi, additional, Yamamoto, Ken, additional, Kim, Hyung-Lae, additional, Han, Bok-Ghee, additional, Cho, Myeong-Chan, additional, Jang, Yangsoo, additional, Kim, Hyo-Soo, additional, Euy Park, Jeong, additional, and Lee, Jong-Young, additional

Published
2013
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33. Genome-wide association study of coronary artery disease in the Japanese

Author

Takeuchi, Fumihiko, primary, Yokota, Mitsuhiro, additional, Yamamoto, Ken, additional, Nakashima, Eitaro, additional, Katsuya, Tomohiro, additional, Asano, Hiroyuki, additional, Isono, Masato, additional, Nabika, Toru, additional, Sugiyama, Takao, additional, Fujioka, Akihiro, additional, Awata, Nobuhisa, additional, Ohnaka, Keizo, additional, Nakatochi, Masahiro, additional, Kitajima, Hidetoshi, additional, Rakugi, Hiromi, additional, Nakamura, Jiro, additional, Ohkubo, Takayoshi, additional, Imai, Yutaka, additional, Shimamoto, Kazuaki, additional, Yamori, Yukio, additional, Yamaguchi, Shuhei, additional, Kobayashi, Shotai, additional, Takayanagi, Ryoichi, additional, Ogihara, Toshio, additional, and Kato, Norihiro, additional

Published
2011
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35. Relation of a common variant of the adiponectin gene to serum adiponectin concentration and metabolic traits in an aged Japanese population

Author

Tanimura, Daisuke, primary, Shibata, Rei, additional, Izawa, Hideo, additional, Hirashiki, Akihiro, additional, Asano, Hiroyuki, additional, Murase, Yosuke, additional, Miyata, Seiko, additional, Nakatochi, Masahiro, additional, Ouchi, Noriyuki, additional, Ichihara, Sahoko, additional, Yasui, Kenji, additional, Yoshida, Tsutomu, additional, Naruse, Keiko, additional, Matsubara, Tatsuaki, additional, and Yokota, Mitsuhiro, additional

Published
2010
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36. Blood Pressure and Hypertension Are Associated With 7 Loci in the Japanese Population

Author

Takeuchi, Fumihiko, primary, Isono, Masato, additional, Katsuya, Tomohiro, additional, Yamamoto, Ken, additional, Yokota, Mitsuhiro, additional, Sugiyama, Takao, additional, Nabika, Toru, additional, Fujioka, Akihiro, additional, Ohnaka, Keizo, additional, Asano, Hiroyuki, additional, Yamori, Yukio, additional, Yamaguchi, Shuhei, additional, Kobayashi, Shotai, additional, Takayanagi, Ryoichi, additional, Ogihara, Toshio, additional, and Kato, Norihiro, additional

Published
2010
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37. Light Sources and Lighting Circuits

Author

YASUDA, Takeo, primary, BESSHO, Makoto, additional, NAOKI, Shouji, additional, SAITO, Akiko, additional, MAEHARA, Akiyoshi, additional, OKADA, Atsunori, additional, ASANO, Hiroyuki, additional, and HASEGAWA, Junichi, additional

Published
2010
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38. Mutation of ARHGAP9 in patients with coronary spastic angina

Author

Takefuji, Mikito, primary, Asano, Hiroyuki, additional, Mori, Kazutaka, additional, Amano, Mutsuki, additional, Kato, Katsuhiro, additional, Watanabe, Takashi, additional, Morita, Yasuhiro, additional, Katsumi, Akira, additional, Itoh, Toshiki, additional, Takenawa, Tadaomi, additional, Hirashiki, Akihiro, additional, Izawa, Hideo, additional, Nagata, Kozo, additional, Hirayama, Haruo, additional, Takatsu, Fumimaro, additional, Naoe, Tomoki, additional, Yokota, Mitsuhiro, additional, and Kaibuchi, Kozo, additional

Published
2009
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39. Light Sources and Lighting Circuit

Author

YASUDA, Takeo, primary, SUWA, Takumi, additional, NAOKI, Shouji, additional, SAITO, Akiko, additional, MAEHARA, Akiyoshi, additional, OKADA, Atsunori, additional, KOMATSU, Naoki, additional, and ASANO, Hiroyuki, additional

Published
2009
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40. Dobutamine Stress Testing as a Diagnostic Tool for Evaluation of Myocardial Contractile Reserve in Asymptomatic or Mildly Symptomatic Patients With Dilated Cardiomyopathy

Author

Kobayashi, Masakazu, primary, Izawa, Hideo, additional, Cheng, Xian Wu, additional, Asano, Hiroyuki, additional, Hirashiki, Akihiro, additional, Unno, Kazumasa, additional, Ohshima, Satoru, additional, Yamada, Takashi, additional, Murase, Yosuke, additional, Kato, Tomoko S., additional, Obata, Koji, additional, Noda, Akiko, additional, Nishizawa, Takao, additional, Isobe, Satoshi, additional, Nagata, Kohzo, additional, Matsubara, Tatsuaki, additional, Murohara, Toyoaki, additional, and Yokota, Mitsuhiro, additional

Published
2008
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41. Abstract 4366: Relation of Functional and Morphological Changes in Mitochondria to Myocardial Contractile and Relaxation Reserves in Asymptomatic to Mildly Symptomatic Patients with Hypertrophic Cardiomyopathy

Author

Unno, Kazumasa, primary, Isobe, Satoshi, additional, Izawa, Hideo, additional, Cheng, Xian W, additional, Kobayashi, Masakazu, additional, Hirashiki, Akihiro, additional, Murase, Yosuke, additional, Asano, Hiroyuki, additional, Yamada, Takashi, additional, Ohshima, Satoru, additional, Nishizawa, Takao, additional, Noda, Akiko, additional, Nagata, Kohzo, additional, Murohara, Toyoaki, additional, and Yokota, Mitsuhiro, additional

Published
2008
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42. Abstract 2523: Azelnidipine Enhances Beneficial Effects of Olmesartan on Left Ventricular Remodeling During the Development of Hypertension-induced Heart Failure

Author

Cheng, Xian Wu, primary, Okumura, Kenji, additional, Nagata, Kohzo, additional, Inoue, Aiko, additional, Zhang, Jie, additional, Nishizawa, Takao, additional, Yamada, Takashi, additional, Murase, Yosuke, additional, Izawa, Hideo, additional, Asano, Hiroyuki, additional, Obata, Koji, additional, Kuzuya, Masafumi, additional, Shi, Guo-Ping, additional, Murohara, Toyoaki, additional, and Yokota, Mitsuhiro, additional

Published
2007
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45. Mineralocorticoid Receptor Antagonism Ameliorates Left Ventricular Diastolic Dysfunction and Myocardial Fibrosis in Mildly Symptomatic Patients With Idiopathic Dilated Cardiomyopathy

Author

Izawa, Hideo, primary, Murohara, Toyoaki, additional, Nagata, Kohzo, additional, Isobe, Satoshi, additional, Asano, Hiroyuki, additional, Amano, Tetsuya, additional, Ichihara, Sahoko, additional, Kato, Tomoko, additional, Ohshima, Satoru, additional, Murase, Yosuke, additional, Iino, Shigeo, additional, Obata, Koji, additional, Noda, Akiko, additional, Okumura, Kenji, additional, and Yokota, Mitsuhiro, additional

Published
2005
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50. Genome-wide association study of coronary artery disease in the Japanese.

Author

Takeuchi, Fumihiko, Yokota, Mitsuhiro, Yamamoto, Ken, Nakashima, Eitaro, Katsuya, Tomohiro, Asano, Hiroyuki, Isono, Masato, Nabika, Toru, Sugiyama, Takao, Fujioka, Akihiro, Awata, Nobuhisa, Ohnaka, Keizo, Nakatochi, Masahiro, Kitajima, Hidetoshi, Rakugi, Hiromi, Nakamura, Jiro, Ohkubo, Takayoshi, Imai, Yutaka, Shimamoto, Kazuaki, and Yamori, Yukio

Subjects
GENOMES, CORONARY disease, CORONARY arteries, BLOOD circulation disorders, BLOOD vessels
Abstract

A new understanding of the genetic basis of coronary artery disease (CAD) has recently emerged from genome-wide association (GWA) studies of common single-nucleotide polymorphisms (SNPs), thus far performed mostly in European-descent populations. To identify novel susceptibility gene variants for CAD and confirm those previously identified mostly in populations of European descent, a multistage GWA study was performed in the Japanese. In the discovery phase, we first genotyped 806 cases and 1337 controls with 451 382 SNP markers and subsequently assessed 34 selected SNPs with direct genotyping (541 additional cases) and in silico comparison (964 healthy controls). In the replication phase, involving 3052 cases and 6335 controls, 12 SNPs were tested; CAD association was replicated and/or verified for 4 (of 12) SNPs from 3 loci: near BRAP and ALDH2 on 12q24 (P=1.6 × 10−34), HLA-DQB1 on 6p21 (P=4.7 × 10−7), and CDKN2A/B on 9p21 (P=6.1 × 10−16). On 12q24, we identified the strongest association signal with the strength of association substantially pronounced for a subgroup of myocardial infarction cases (P=1.4 × 10−40). On 6p21, an HLA allele, DQB1*0604, could show one of the most prominent association signals in an ∼8-Mb interval that encompasses the LTA gene, where an association with myocardial infarction had been reported in another Japanese study. CAD association was also identified at CDKN2A/B, as previously reported in different populations of European descent and Asians. Thus, three loci confirmed in the Japanese GWA study highlight the likely presence of risk alleles with two types of genetic effects - population specific and common - on susceptibility to CAD. [ABSTRACT FROM AUTHOR]

Published
2012
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