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1. Advanced Age Is an Independent Risk Factor for Severe Infections and Mortality in Patients Given Anti–Tumor Necrosis Factor Therapy for Inflammatory Bowel Disease

Author

Cottone, Mario, Kohn, Anna, Daperno, Marco, Armuzzi, Alessandro, Guidi, Luisa, D'Inca, Renata, Bossa, Fabrizio, Angelucci, Erika, Biancone, Livia, Gionchetti, Paolo, Ardizzone, Sandro, Papi, Claudio, Fries, Walter, Danese, Silvio, Riegler, Gabriele, Cappello, Maria, Castiglione, Fabiana, Annese, Vito, and Orlando, Ambrogio

Published
2011
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3. Su1266 Characterization of Incident Cases of Cancer in Inflammatory Bowel Disease: A Prospective Multicenter Nested Case-Control IG-IBD Study

Author

Biancone, Livia, primary, Armuzzi, Alessandro, additional, Lia, Scribano Maria, additional, D'Inca, Renata, additional, Papi, Claudio, additional, Spina, Luisa, additional, Ruffa, Alessandra, additional, Petruzziello, Carmelina, additional, Guidi, Luisa, additional, Kohn, Anna, additional, Calabrese, Emma, additional, Mocciaro, Filippo, additional, Alvisi, Patrizia, additional, Angelucci, Erika, additional, Monterubbianesi, Rita, additional, Fries, Walter, additional, Riegler, Gabriele, additional, Castiglione, Fabiana, additional, Margagnoni, Giovanna, additional, Renna, Sara, additional, Di Mitri, Roberto, additional, Meucci, Gianmichele, additional, Rogai, Francesca, additional, Ardizzone, Sandro, additional, Rossi, Alessandra, additional, Orlando, Ambrogio, additional, and Pallone, Francesco, additional

Published
2015
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4. Sa1270 Early Post-Operative Endoscopic Recurrence in Crohn's Disease Patients: Data From a Large Prospective Italian Multicenter Cohort

Author

Orlando, Ambrogio, primary, Mocciaro, Filippo, additional, Scimeca, Daniela, additional, Rispo, Antonio, additional, Scribano, Maria Lia, additional, Testa, Anna, additional, Aratari, Annalisa, additional, Bossa, Fabrizio, additional, Tambasco, Rosy, additional, Angelucci, Erika, additional, Onali, Sara, additional, Cappello, Maria, additional, Fries, Walter, additional, D'Incà, Renata, additional, Martinato, Matteo, additional, Castiglione, Fabiana, additional, Papi, Claudio, additional, Annese, Vito, additional, Gionchetti, Paolo, additional, Rizzello, Fernando, additional, Vernia, Piero, additional, Biancone, Livia, additional, Kohn, Anna, additional, and Cottone, Mario, additional

Published
2012
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5. S1214 Early Post-Operative Endoscopic Recurrence in Crohn's Disease in an Italian Multicentric Cohort

Author

Orlando, Ambrogio, primary, Scimeca, Daniela, additional, Mocciaro, Filippo, additional, Testa, Anna, additional, Aratari, Annalisa, additional, Bossa, Fabrizio, additional, Tambasco, Rosy, additional, Angelucci, Erika, additional, Onali, Sara, additional, Cappello, Maria, additional, Fries, Walter, additional, D'Incà, Renata, additional, Castiglione, Fabiana, additional, Papi, Claudio, additional, Annese, Vito, additional, Gionchetti, Paolo, additional, Vernia, Piero, additional, Biancone, Livia, additional, and Cottone, Mario, additional

Published
2010
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6. S1112 Newly Diagnosed Neoplasia in a Cohort of Crohn's Disease Patients Treated or Untreated with Infliximab Followed Up in the Long Term: A Multicenter Matched-Pair Study

Author

Biancone, Livia, primary, Orlando, Ambrogio, additional, Kohn, Anna, additional, Ardizzone, Sandro, additional, Daperno, Marco, additional, Angelucci, Erika, additional, Castiglione, Fabiana, additional, D'Incà, Renata, additional, Papi, Claudio, additional, Meucci, Gianmichele, additional, Riegler, Gabriele, additional, Petruzziello, Carmelina, additional, Rizzello, Fernando, additional, Sica, Giuseppe, additional, Mocciaro, Filippo, additional, Onali, Sara, additional, Calabrese, Emma, additional, Cottone, Mario, additional, and Pallone, Francesco, additional

Published
2009
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7. M1134 Newly Diagnosed Neoplasia in a Cohort of Crohn's Disease Patients Treated with Infliximab: A 3 Years Longer Follow Up from a Multicenter Matched-Pair Study

Author

Biancone, Livia, primary, Orlando, Ambrogio, additional, Kohn, Anna, additional, Ardizzone, Sandro, additional, Daperno, Marco, additional, Angelucci, Erika, additional, Castiglione, Fabiana, additional, D'Incà, Renata, additional, Papi, Claudio, additional, Rizzello, Fernando, additional, Meucci, Gianmichele, additional, Riegler, Gabriele, additional, Petruzziello, Carmelina, additional, Mocciaro, Filippo, additional, Onali, Sara, additional, Calabrese, Emma, additional, Cottone, Mario, additional, and Pallone, Francesco, additional

Published
2008
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9. Inflammatory Bowel Disease Phenotype as Risk Factor for Cancer in a Prospective Multicentre Nested Case-Control IG-IBD Study

Author

Biancone, L, Armuzzi, A, Scribano, Ml, D'Inca, R, Castiglione, F, Papi, C, Angelucci, E, Daperno, M, Mocciaro, F, Riegler, G, Fries, W, Meucci, G, Alvisi, P, Spina, L, Ardizzone, S, Petruzziello, C, Ruffa, A, Kohn, A, Vecchi, M, Guidi, L, Di Mitri, R, Renna, S, Emma, C, Rogai, F, Rossi, A, Orlando, A, Pallone, F, Italian Group for the study of Inflammatory Bowel, Disease., Biancone, Livia, Armuzzi, Alessandro, Scribano, Maria Lia, D'Inca, Renata, Castiglione, Fabiana, Papi, Claudio, Angelucci, Erika, Daperno, Marco, Mocciaro, Filippo, Riegler, Gabriele, Fries, Walter, Meucci, Gianmichele, Alvisi, Patrizia, Spina, Luisa, Ardizzone, Sandro, Petruzziello, Carmelina, Ruffa, Alessandra, Kohn, Anna, Vecchi, Maurizio, Guidi, Luisa, Di Mitri, Roberto, Renna, Sara, Emma, Calabrese, Rogai, Francesca, Rossi, Alessandra, Orlando, Ambrogio, and Pallone, Francesco

Subjects
Adult, Male, medicine.medical_specialty, Pancolitis, Adolescent, Colorectal cancer, phenotype, Settore MED/12 - GASTROENTEROLOGIA, cancer risk, Inflammatory bowel disease, Aged, Aged, 80 and over, Case-Control Studies, Female, Follow-Up Studies, Humans, Immunologic Factors, Incidence, Inflammatory Bowel Diseases, Logistic Models, Middle Aged, Multivariate Analysis, Neoplasms, Prospective Studies, Risk Factors, Young Adult, Phenotype, Gastroenterology, 03 medical and health sciences, 0302 clinical medicine, Internal medicine, 80 and over, medicine, Risk factor, Prospective cohort study, business.industry, Settore MED/09 - MEDICINA INTERNA, Cancer, General Medicine, medicine.disease, Ulcerative colitis, 030220 oncology & carcinogenesis, Nested case-control study, 030211 gastroenterology & hepatology, medicine.symptom, business
Abstract

Background and Aims: Cancer risk in inflammatory bowel disease [IBD] is still debated. In a prospective, multicentre, nested case-control study, we aimed to characterise incident cases of cancer in IBD. The role of immunomodulators vs clinical characteristics of IBD as risk factors for cancer was also investigated. Materials and Methods: From January 2012 to December 2014, each IBD patient with incident cancer was matched with two IBD patients without cancer for: IBD type, gender, and age. Risk factors were assessed by multivariate regression analysis. Results: IBD patients considered numbered 44619: 21953 Crohn’s disease \[CD], 22666 ulcerative colitis [UC]. Cancer occurred in 174 patients: 99 CD [CD-K], 75 UC [UC-K]. Controls included 198 CD [CD-C], 150 UC [UC-C]. Cancer incidence in IBD was 3.9/1000, higher in CD (4.5/1000 [99/21,953]) than in UC (3.3/1000 [75/22,666]; p = 0.042). Cancers involved: digestive system [36.8%], skin [13.2%], urinary tract [12.1%], lung [8.6%], breast [8%], genital tract [6.9%], thyroid [4.6%], lymphoma [3.5%], others [6.3%]. In CD, penetrating behaviour and combined thiopurines and tumour necrosis factor alpha [TNFα] antagonists were risk factors for cancer overall: odds ratio [OR\] (95% confidence interval \[CI] 2.33 [1.01–5.47]); 1.97 [1.1–3.5]; and for extracolonic cancers 3.9 [1.56–10.1]; 2.15 [1.17–4.1], respectively. In UC, risk factors were pancolitis and disease-related surgery for cancer overall (OR: 2.52 [1.26–5.1]; 5.09 [1.73–17.1]); disease-related surgery for colorectal cancer [CRC\] (OR 3.6 [1.0–12]); and extensive and left-sided vs distal UC for extracolonic cancers (OR: 2.55 [1.15–5.9]; 2.6 [1.04–6.6]), respectively. Conclusions: In a multicentre study, penetrating CD and extensive UC were risk factors for cancer overall. Cancer incidence was higher in CD than in UC.

Published
2016

10. Narrow-band imaging endoscopy to assess mucosal angiogenesis in inflammatory bowel disease: a pilot study.

Author

Danese S, Fiorino G, Angelucci E, Vetrano S, Pagano N, Rando G, Spinelli A, Malesci A, and Repici A

Subjects
Biopsy, Colitis, Ulcerative immunology, Crohn Disease immunology, Humans, Immunohistochemistry, Microvessels immunology, Microvessels pathology, Neovascularization, Pathologic immunology, Pilot Projects, Platelet Endothelial Cell Adhesion Molecule-1 analysis, Predictive Value of Tests, Severity of Illness Index, Colitis, Ulcerative pathology, Colon blood supply, Colonoscopy methods, Crohn Disease pathology, Intestinal Mucosa blood supply, Neovascularization, Pathologic pathology
Abstract

Aim: To investigate whether narrow band imaging (NBI) is a useful tool for the in vivo detection of angiogenesis in inflammatory bowel disease (IBD) patients., Methods: Conventional and NBI colonoscopy was performed in 14 patients with colonic inflammation (8 ulcerative colitis and 6 Crohn's disease). Biopsy samples were taken and CD31 expression was assayed immunohistochemically; microvascular density was assessed by vessel count., Results: In areas that were endoscopically normal but positive on NBI, there was a significant (P < 0.05) increase in angiogenesis (12 +/- 1 vessels/field vs 18 +/- 2 vessels/field) compared with areas negative on NBI. In addition, in areas that were inflamed on white light endoscopy and positive on NBI, there was a significant (P < 0.01) increase in vessel density (24 +/- 7 vessels/field) compared with NBI-negative areas., Conclusion: NBI may allow in vivo imaging of intestinal angiogenesis in IBD patients.

Published
2010
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