11 results on '"Anabel Chade"'
Search Results
2. Detecting cognitive impairment in patients with Parkinson's disease using a brief cognitive screening tool: Addenbrooke's Cognitive Examination (ACE)
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Anabel Chade, María Roca, Teresa Torralva, Ezequiel Gleichgerrcht, Nicolás Fabbro, Gonzalo Gómez Arévalo, Oscar Gershanik, and Facundo Manes
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Parkinson's disease ,Alzheimer's disease ,frontotemporal dementia ,screening tools ,Addenbrooke's Cognitive Examination (ACE). ,Neurosciences. Biological psychiatry. Neuropsychiatry ,RC321-571 - Abstract
Abstract Detecting cognitive impairment in patients with Parkinson's disease is crucial for good clinical practice given the new therapeutic possibilities available. When full neuropsychological evaluations are not available, screening tools capable of detecting cognitive difficulties become crucial. Objective: The goal of this study was to investigate whether the Spanish version of the Addenbrooke's Cognitive Examination (ACE) is capable of detecting cognitive difficulties in patients with Parkinson's disease and discriminating their cognitive profile from patients with dementia. Methods: 77 early dementia patients (53 with Alzheimer's Disease and 24 with Frontotemporal Dementia), 22 patients with Parkinson's disease, and 53 healthy controls were evaluated with the ACE. Results: Parkinson's disease patients significantly differed from both healthy controls and dementia patients on ACE total score. Conclusions: This study shows that the Spanish version of the ACE is capable of detecting patients with cognitive impairment in Parkinson's disease and is able to differentiate them from patients with dementia based on their general cognitive status. more...
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3. Decreased Palpebral Fissure in Patients with Parkinson's Disease
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Gonzalo Gomez Arevalo, Oscar S. Gershanik, Anabel Chade, Gabriel Mizraji, Marina Sanchez Abraham, and S. Garcia
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0301 basic medicine ,Levodopa ,medicine.medical_specialty ,Pediatrics ,animal structures ,Parkinson's disease ,Population ,03 medical and health sciences ,0302 clinical medicine ,Medicine ,education ,Research Articles ,education.field_of_study ,business.industry ,Odds ratio ,medicine.disease ,Confidence interval ,Surgery ,030104 developmental biology ,Palpebral fissure ,Neurology ,embryonic structures ,Laterality ,Observational study ,Neurology (clinical) ,business ,030217 neurology & neurosurgery ,medicine.drug - Abstract
Background The diagnosis of Parkinson's disease (PD) is based exclusively on clinical criteria established by the Queen Square Brain Bank. On occasion, these clinical symptoms may be subtle and inconclusive; therefore, it becomes necessary to appeal to contributory criteria to establish a correct diagnosis. The authors propose the observation of palpebral fissure (PF) asymmetry as an additional criterion for the diagnosis of PD. Objectives The objectives of this study were to determine whether decreased PF (DPF) is more prevalent in patients with PD than in the general population and whether DPF in PD coincides with the side of onset of parkinsonian symptomatology. Methods In total, 112 consecutive patients with a diagnosis of PD and 112 control participants without PD were selected between April and June 2014. At the office visit, it was established through clinical observation whether DPF was present. In patients with PD, it was determined whether the DPF was consistent with the side of onset of parkinsonian symptomatology. Results Of 112 patients with PD, 39 (35%) had DPF clinically evident DPF, and, in 34 (87%), the DPF was consistent with the laterality of parkinsonian signs. In the control group, only 12% (14 of 112 controls) had PF asymmetry. The difference in prevalence of DPF between these groups was statistically significant (P < 0.0001), with an odds ratio of 3.7 (95% confidence interval, 1.8–7.3). Twenty-eight of the 39 patients with PD who had PF asymmetry were treated with levodopa. Conclusions Although the data are purely observational, it may be concluded that DPF coincidental with the side of initial parkinsonian symptomatology in patients with probable PD is an additional sign worth considering. more...
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- 2016
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4. Protective glove use and hygiene habits modify the associations of specific pesticides with Parkinson's disease
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Anabel Chade, Cheryl Meng, Freya Kamel, Connie Marras, Marie Richards, Meike Kasten, David M. Umbach, Monica Korell, Caroline M. Tanner, G. Webster Ross, J. William Langston, Jane A. Hoppin, Melissa Furlong, Grace S. Bhudhikanok, Kathleen Comyns, Samuel M. Goldman, Dale P. Sandler, and Aaron Blair more...
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Male ,Aging ,Parkinson's disease ,Rural Health ,Neurodegenerative ,Occupational safety and health ,Toxicology ,Habits ,chemistry.chemical_compound ,Paraquat ,Hygiene ,Surveys and Questionnaires ,Personal protective equipment ,80 and over ,Medicine ,Workplace ,lcsh:Environmental sciences ,General Environmental Science ,media_common ,Aged, 80 and over ,lcsh:GE1-350 ,Neurodegenerative diseases ,Parkinson Disease ,Agriculture ,Middle Aged ,Neurological ,Female ,medicine.drug ,Risk ,Adult ,media_common.quotation_subject ,Gloves ,Article ,Rotenone ,Occupational Exposure ,Environmental health ,North Carolina ,Humans ,Pesticides ,Movement disorders ,Permethrin ,Occupational Health ,Aged ,business.industry ,Neurosciences ,Case-control study ,Pesticide ,equipment and supplies ,medicine.disease ,Iowa ,Trifluralin ,Brain Disorders ,Protective ,chemistry ,Case-Control Studies ,Gloves, Protective ,business ,Environmental Sciences - Abstract
Pesticides have been associated with Parkinson's disease (PD), and protective gloves and workplace hygiene can reduce pesticide exposure. We assessed whether use of gloves and workplace hygiene modified associations between pesticides and PD. The Farming and Movement Evaluation (FAME) study is a nested case–control study within the Agricultural Health Study. Use of protective gloves, other PPE, and hygiene practices were determined by questionnaire (69 cases and 237 controls were included). We considered interactions of gloves and hygiene with ever-use of pesticides for all pesticides with ≥5 exposed and unexposed cases and controls in each glove-use stratum (paraquat, permethrin, rotenone, and trifluralin). 61% of respondents consistently used protective gloves and 87% consistently used ≥2 hygiene practices. Protective glove use modified the associations of paraquat and permethrin with PD: neither pesticide was associated with PD among protective glove users, while both pesticides were associated with PD among non-users (paraquat OR 3.9 [95% CI 1.3, 11.7], interaction p = 0.15; permethrin OR 4.3 [95% CI 1.2, 15.6] interaction p = 0.05). Rotenone was associated with PD regardless of glove use. Trifluralin was associated with PD among participants who used more...
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- 2015
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5. Screening for idiopathic REM sleep behavior disorder: usefulness of actigraphy
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Werner Poewe, Joan Santamaria, Ambra Stefani, Lisa-Marie Neier, Anabel Chade, Friederike Sixel-Döring, Birgit Högl, Oscar S. Gershanik, Anna Heidbreder, Marc Guaita, Thomas Mitterling, Aleksander Videnovic, Gregor K. Wenning, Elisabeth Brandauer, Alex Iranzo, and Claudia Trenkwalder more...
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Male ,medicine.medical_specialty ,Polysomnography ,alpha-synuclein ,Population ,REM Sleep Behavior Disorder ,Sleep medicine ,REM sleep behavior disorder ,Likelihood ratios in diagnostic testing ,Neurological Disorders ,RBD ,03 medical and health sciences ,0302 clinical medicine ,Physiology (medical) ,Surveys and Questionnaires ,Medicine ,Humans ,Mass Screening ,Restless legs syndrome ,sleep ,education ,parkinsonism ,Aged ,screening method ,education.field_of_study ,medicine.diagnostic_test ,business.industry ,Sleep apnea ,Actigraphy ,Middle Aged ,medicine.disease ,3. Good health ,030228 respiratory system ,Physical therapy ,Female ,Neurology (clinical) ,business ,030217 neurology & neurosurgery - Abstract
Study Objectives To evaluate the utility of multimodal low-cost approaches including actigraphy, a wrist-worn device monitoring rest/activity cycles, in identifying patients with idiopathic REM sleep behavior disorder (iRBD). Methods Seventy patients diagnosed with sleep disorders causing different motor manifestations during sleep (iRBD, sleep apnea, restless legs syndrome) and 20 subjects without any relevant motor manifestation during sleep, underwent video-polysomnography (vPSG) and 2 week actigraphy, completed six validated RBD screening questionnaires, and sleep apps use was assessed. Actigraphy was analyzed automatically, and visually by seven blinded sleep medicine experts who rated as “no,” “possible,” and “probable” RBD. Results Quantitative actigraphy analysis distinguished patients from controls, but not between patients with different types of motor activity during sleep. Visual actigraphy rating by blinded experts in sleep medicine using pattern recognition identified vPSG confirmed iRBD with 85%–95% sensitivity, 79%–91% specificity, 81%–91% accuracy, 57.7% ± 11.3% positive predictive value, 95.1% ± 3.3% negative predictive value, 6.8 ± 2.2 positive likelihood ratio, 0.14 ± 0.05 negative likelihood ratio and 0.874–0.933 area under the ROC curve (AUC). AUC of the best performing questionnaire was 0.868. Few patients used sleep apps; therefore, their potential utility in the evaluated patients’ groups is limited. Conclusions Visual analysis of actigraphy using pattern recognition can identify subjects with iRBD, and is able to distinguish iRBD from other motor activities during sleep, even when patients are not aware of the disease in contrast to questionnaires. Therefore, actigraphy can be a reliable screening instrument for RBD potentially useful in the general population. more...
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- 2017
6. Dietary fat intake, pesticide use, and Parkinson's disease
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G. Webster Ross, Honglei Chen, David M. Umbach, Gina Richardson, Meike Kasten, Freya Kamel, Monica Korell, Jane A. Hoppin, Cheryl Meng, Connie Marras, Anabel Chade, Marie Richards Barber, Dale P. Sandler, Caroline M. Tanner, Aaron Blair, J. William Langston, Kathleen Comyns, Grace S. Bhudhikanok, and Samuel M. Goldman more...
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Male ,Aging ,Parkinson's disease ,Physiology ,Rural Health ,Neurodegenerative ,chemistry.chemical_compound ,Paraquat ,Risk Factors ,80 and over ,Food science ,Aged, 80 and over ,Omega-3 ,chemistry.chemical_classification ,Fatty Acids ,Parkinson Disease ,Middle Aged ,Neurology ,Neurological ,Cohort ,Female ,Cognitive Sciences ,Polyunsaturated fatty acid ,Adult ,Clinical Sciences ,Article ,Clinical Research ,Fatty Acids, Omega-3 ,medicine ,Humans ,Pesticides ,Aged ,Nutrition ,Neurology & Neurosurgery ,business.industry ,Prevention ,Neurosciences ,Rotenone ,Odds ratio ,Pesticide ,medicine.disease ,Dietary Fats ,Confidence interval ,Diet ,Brain Disorders ,chemistry ,Case-Control Studies ,Polyunsaturated fatty acids ,Neurology (clinical) ,Geriatrics and Gerontology ,business ,Dietary fat - Abstract
Background: Dietary fat intake may modify Parkinson’s disease (PD) risk directly or by altering the response to environmental neurotoxicants including pesticides. Methods: We conducted a case-control study of PD nested in the Agricultural Health Study (AHS), a cohort of pesticide applicators and spouses. We evaluated diet and pesticide use before diagnosis in 89 PD cases, confirmed by movement disorder specialists, or a corresponding date in 336 frequencymatched controls. Associations were evaluated using multivariate logistic regression to estimate odds ratios (ORs) and 95% confidence intervals (CIs). Results: In the AHS, PD was inversely associated with N-3 polyunsaturated fatty acids (PUFAs) (OR 0.4, 95% CI 0.2e0.8 for highest vs. lowest tertile) and the N-3 precursor a-linolenic acid (0.4, 0.2e0.8). In a meta-analysis of nine studies, including the present one, PD was inversely associated with a-linolenic acid (0.81, 0.68e0.96). In the AHS, associations of PD with the pesticides paraquat and rotenone were modified by fat intake. The OR for paraquat was 4.2 (1.5e12) in individuals with PUFA intake below the median but 1.2 (0.4e3.4) in those with higher intake (p-interaction ¼ 0.10). The OR for rotenone was 5.8 (2.3e15) in those with saturated fat intake above the median but 1.5 (0.5e4.2) in those with lower intake (p-interaction ¼ 0.02). Conclusions: PUFA intake was consistently associated with lower PD risk, and dietary fats modified the association of PD risk with pesticide exposure. If confirmed, these findings suggest that a diet high in PUFAs and low in saturated fats might reduce risk of PD. Published by Elsevier Ltd. more...
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- 2014
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7. Differences in MDS-UPDRS Scores Based on Hoehn and Yahr Stage and Disease Duration
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Barbara C. Tilley, Eva Reiter, Klaus Seppi, Thomas Foltynie, Carlos Singer, Iciar Aviles-Olmos, Carmen Rodriguez-Blazquez, Michal Minár, Milan Grofik, Pille Taba, Vladimir Han, Henry Moore, Peter Valkovič, Alberto Bergareche-Yarza, Christopher G. Goetz, Eve Benchetrit, Matej Skorvanek, Graziella Mangone, Pablo Martinez-Martin, Anabel Chade, Anette Schrag, Werner Poewe, Norbert Kovács, Veronika Datieva, Amin Cervantes-Arriaga, Zuzana Gdovinova, Mario Alvarez-Sanchez, Nelida Garretto, Bernadette Pinter, Florence Cormier, Mari Muldmaa, Amelia Mendoza-Rodriguez, Juan Carlos Martínez-Castrillo, Oleg Levin, Jean-Christophe Corvol, Charline Benoit, Liis Kadastik-Eerme, David A. Gallagher, Tomoko Arakaki, Glenn T. Stebbins, Mayela Rodríguez-Violante, Monica M. Kurtis, Jing Huang, Karin Rallmann, Oscar S. Gershanik, Zsuzsanna Aschermann, and Christoph Mueller more...
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0301 basic medicine ,Gerontology ,medicine.medical_specialty ,Parkinson's disease ,Mds updrs ,Disease duration ,Hoehn and Yahr ,Part iii ,scale ,03 medical and health sciences ,0302 clinical medicine ,Rating scale ,Internal medicine ,medicine ,Stage (cooking) ,Motor assessment ,Research Articles ,Mean age ,Movement Disorder Society Unified Parkinson's Disease Rating Scale (MDS‐UPDRS) ,medicine.disease ,nervous system diseases ,030104 developmental biology ,Neurology ,Neurology (clinical) ,disease duration ,Psychology ,030217 neurology & neurosurgery - Abstract
BACKGROUND: The Movement Disorder Society Unified Parkinson's Disease Rating Scale (MDS‐UPDRS) is a newly developed tool to assess Parkinson's disease (PD). Changes in scores on the scale over the course of PD, including increasing disease duration and Hoehn and Yahr (HY) stages, have not been described. The objectives of this study were to analyze MDS‐UPDRS scores on Parts I through IV and their differences based on HY stage and disease duration in a large cohort of patients with PD. METHODS: For this cross‐sectional study, demographic data and MDS‐UPDRS scores were collected, including HY stage. Subscores on MDS‐UPDRS Parts I through IV were analyzed using 1‐way analyses of variance for each HY stage and in 5‐year increments of disease duration. Part III (motor assessment) scores were analyzed separately for on and off states. RESULTS: The mean age of the 3206 patients was 65.8 ± 10.6 years, 53.3% were men, the mean disease duration was 11.5 ± 4.6 years, and the median HY stage was 2 (range, 0–5); 2156 patients were examined in an on state and 987 were examined in an off state. Scores for all MDS‐UPDRS parts increased significantly through HY stages 1 through 5, with an average increase of 3.8, 7.7, 14.6, and 2.0 points consecutively for parts I through IV, respectively. For the 5‐year increments of disease duration, MDS‐UPDRS subscores increased by an average of 1.6, 3.3, 4.2, and 1.4 points consecutively for parts I through IV, respectively. This increase was significant only during the first 15 years of disease for all 4 parts, including part III scores evaluated in both on and off states. CONCLUSIONS: MDS‐UPDRS scores for all 4 parts increase significantly with every HY stage and also with 5‐year increments of disease duration in the first 15 years of the disease. more...
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- 2017
8. Verbal Fluency as a Rapid Screening Test for Cognitive Impairment in Early Parkinson's Disease
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Sandra Baez, Agustín Ibáñez, Ezequiel Gleichgerrcht, Oscar S. Gershanik, Anabel Chade, Teresa Torralva, María Roca, Teresa Laffaye, Diana Bruno, and Facundo Manes
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Male ,medicine.medical_specialty ,Parkinson's disease ,CIENCIAS MÉDICAS Y DE LA SALUD ,Neurociencias ,MEDLINE ,Disease ,Neuropsychological Tests ,Executive Function ,Rapid screening test ,medicine ,Humans ,Verbal fluency test ,Parkinson ,Psychiatry ,Cognitive impairment ,Analysis of Variance ,Verbal Behavior ,Verbal Fluency ,Parkinson Disease ,Cognition ,purl.org/becyt/ford/3.1 [https] ,medicine.disease ,Psychiatry and Mental health ,Medicina Básica ,ROC Curve ,Female ,purl.org/becyt/ford/3 [https] ,Neurology (clinical) ,Analysis of variance ,Cognition Disorders ,Psychology ,Clinical psychology - Abstract
The phonological verbal fluencytestcan actasafast screeningtesttodetectcognitive deficits in neurological conditions. In the present study, its utility in the detection of executive deficits in patients with early Parkinson’sdisease is demonstrated. Fil: Torralva, Teresa. Instituto de Neurología Cognitiva; Argentina. Universidad Favaloro; Argentina. Universidad Diego Portales; Chile Fil: Laffaye, Teresa. Instituto de Neurología Cognitiva; Argentina Fil: Báez, Sandra. Universidad Diego Portales; Chile Fil: Gleichgerrcht, Ezequiel. Instituto de Neurología Cognitiva; Argentina Fil: Bruno, Diana. Instituto de Neurología Cognitiva; Argentina Fil: Chade, Anabel. Universidad Favaloro; Argentina. Instituto de Neurología Cognitiva; Argentina Fil: Ibáñez Barassi, Agustín Mariano. Universidad Favaloro; Argentina. Universidad Diego Portales; Chile. Instituto de Neurología Cognitiva; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina Fil: Manes, Facundo Francisco. Instituto de Neurología Cognitiva; Argentina. Universidad Favaloro; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina Fil: Gershanik, Oscar Samuel. Instituto de Neurología Cognitiva; Argentina. Universidad Favaloro; Argentina Fil: Roca, María. Instituto de Neurología Cognitiva; Argentina. Universidad Favaloro; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Diego Portales; Chile more...
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- 2015
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9. The relationship between executive functions and fluid intelligence in Parkinson's disease
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Anabel Chade, Gonzalo Gomez Arevalo, Teresa Torralva, John S. Duncan, O. Gershanik, María Roca, Facundo Manes, and Ezequiel Gleichgerrcht
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Parkinson's disease ,Intelligence ,Theory of Mind ,behavioral disciplines and activities ,Executive Function ,Wisconsin Card Sorting Test ,Theory of mind ,medicine ,Humans ,Verbal fluency test ,Human multitasking ,Applied Psychology ,Cognitive deficit ,fluid intelligence ,Aged ,Neuropsychology ,Parkinson Disease ,Original Articles ,Middle Aged ,frontal lobe ,Executive functions ,Psychiatry and Mental health ,Frontal lobe ,medicine.symptom ,Psychology ,Cognitive psychology - Abstract
BackgroundWe recently demonstrated that decline in fluid intelligence is a substantial contributor to frontal deficits. For some classical ‘executive’ tasks, such as the Wisconsin Card Sorting Test (WCST) and Verbal Fluency, frontal deficits were entirely explained by fluid intelligence. However, on a second set of frontal tasks, deficits remained even after statistically controlling for this factor. These tasks included tests of theory of mind and multitasking. As frontal dysfunction is the most frequent cognitive deficit observed in early Parkinson's disease (PD), the present study aimed to determine the role of fluid intelligence in such deficits.MethodWe assessed patients with PD (n=32) and control subjects (n=22) with the aforementioned frontal tests and with a test of fluid intelligence. Group performance was compared and fluid intelligence was introduced as a covariate to determine its role in frontal deficits shown by PD patients.ResultsIn line with our previous results, scores on the WCST and Verbal Fluency were closely linked to fluid intelligence. Significant patient–control differences were eliminated or at least substantially reduced once fluid intelligence was introduced as a covariate. However, for tasks of theory of mind and multitasking, deficits remained even after fluid intelligence was statistically controlled.ConclusionsThe present results suggest that clinical assessment of neuropsychological deficits in PD should include tests of fluid intelligence, together with one or more specific tasks that allow for the assessment of residual frontal deficits associated with theory of mind and multitasking. more...
- Published
- 2012
10. Comparing the Neuropsychiatric Profile of Patients with Alzheimer Disease Who Present Spared versus Impaired Executive Functioning
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Facundo Manes, Anabel Chade, Ezequiel Gleichgerrcht, Teresa Torralva, and María Roca
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medicine.medical_specialty ,Article Subject ,business.industry ,Significant difference ,Neuropsychology ,Functional impact ,lcsh:Geriatrics ,medicine.disease ,Motor symptoms ,lcsh:RC952-954.6 ,medicine ,Clinical Study ,Dementia ,In patient ,Geriatrics and Gerontology ,Alzheimer's disease ,Differential diagnosis ,Psychiatry ,business ,Clinical psychology - Abstract
Background. A “dysexecutive” group of patients with Alzheimer disease (AD) has been previously identified, and these patients have been found to present higher frequency of psychiatric symptoms and more pronounced functional impact. This study aimed at evaluating the frequency of neuropsychiatric symptoms in patients with early AD who present with impaired executive functioning.Methods. Thirty patients with early AD diagnosis were divided into a spared (SEF) and an impaired (IEF) executive functioning group according to their performance scores on neuropsychological tests. Their closest relatives or caregivers completed the Cambridge behavioral inventory (CBI), which assesses behavioral symptoms grouped into 13 categories.Results. A significant difference was exclusively found between SEF and IEF in terms of the frequency of stereotypies and repetitive motor behavior (U=60.5,P=.024).Conclusions. The presence of stereotypies could be associated with a dysexecutive profile in AD patients. These results shed light on the role of frontal circuitry in the expression of motor symptoms in AD and prompt for further research that will contribute to the differential diagnosis both of different subtypes of AD and other types of dementia. more...
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- 2011
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11. Detecting cognitive impairment in patients with Parkinson's disease using a brief cognitive screening tool: Addenbrooke's Cognitive Examination (ACE)
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Oscar S. Gershanik, Gonzalo Gomez Arevalo, Nicolás Fabbro, Anabel Chade, Teresa Torralva, Facundo Manes, Ezequiel Gleichgerrcht, and María Roca
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medicine.medical_specialty ,Parkinson's disease ,doença de Alzheimer ,Cognitive Neuroscience ,Disease ,Exame Cognitivo de Addenbrooke ,frontotemporal dementia ,lcsh:RC321-571 ,Addenbrooke's Cognitive Examination (ACE) ,Physical medicine and rehabilitation ,medicine ,Dementia ,lcsh:Neurosciences. Biological psychiatry. Neuropsychiatry ,Neuropsychology ,Cognition ,instrumentos de rastreio ,Original Articles ,Alzheimer's disease ,medicine.disease ,Addenbrooke's cognitive examination ,Addenbrooke’s Cognitive Examination (ACE) ,screening tools ,Sensory Systems ,doença de Parkinson ,Neurology ,demência frontotemporal ,Good clinical practice ,Physical therapy ,Parkinson’s disease ,Neurology (clinical) ,Geriatrics and Gerontology ,Psychology ,Alzheimer’s disease ,Frontotemporal dementia - Abstract
Detecting cognitive impairment in patients with Parkinson's disease is crucial for good clinical practice given the new therapeutic possibilities available. When full neuropsychological evaluations are not available, screening tools capable of detecting cognitive difficulties become crucial. Objective: The goal of this study was to investigate whether the Spanish version of the Addenbrooke's Cognitive Examination (ACE) is capable of detecting cognitive difficulties in patients with Parkinson's disease and discriminating their cognitive profile from patients with dementia. Methods: 77 early dementia patients (53 with Alzheimer's Disease and 24 with Frontotemporal Dementia), 22 patients with Parkinson's disease, and 53 healthy controls were evaluated with the ACE. Results: Parkinson's disease patients significantly differed from both healthy controls and dementia patients on ACE total score. Conclusions: This study shows that the Spanish version of the ACE is capable of detecting patients with cognitive impairment in Parkinson's disease and is able to differentiate them from patients with dementia based on their general cognitive status. Resumo A detecção de comprometimento cognitivo em pacientes com doença de Parkinson é crucial para uma boa prática clínica devido às novas possibilidades terapêuticas disponíveis. Quando uma avaliação neuropsicológica completa não está disponível, instrumentos de rastreio capazes de detectar dificuldades cognitivas tornam-se cruciais. Objetivo: Investigar se a versão espanhola do Addenbrooke´s Cognitive Examination (ACE) é capaz de detectar dificuldades cognitivas em pacientes com doença de Parkinson e discriminar seu perfil cognitivo de pacientes com demência. Métodos: 77 pacientes com demência leve (53 com doença de Alzheimer e 24 com demência frontotemporal), 22 pacientes com doença de Parkinson e 53 controles saudáveis foram avaliados com a ACE. Resultados: Os pacientes com doença de Parkinson significativamente diferiram de controles saudáveis e pacientes com demência no escore total do ACE. Conclusões: Este estudo mostra que a versão espanhola do ACE é capaz de detectar pacientes com comprometimento cognitivo na doença de Parkinson e de diferenciá-los de pacientes com demência baseados no seu estado cognitivo geral. more...
- Published
- 2008
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