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7. A case of equine multicentric lymphoma: Clinical, microscopical, and molecular findings.

Author

Fernandes Silva, Gabriela, Esteves Ribeiro, Tiago, Cunha, Raquel, Salas, Patricia Becerra, Guimarães, Tiago, Ribeiro, Mário, Barros, Gonçalo, Carvalho, Fátima, Mesquita, João Rodrigo, and Amorim, Irina

Subjects
MULTIPLE organ failure, T-cell lymphoma, LYMPHOMAS, ANIMAL reproduction, SYMPTOMS, TRACHEA
Abstract

Background: Although relatively uncommon, lymphoma is the most prevalent haematopoietic neoplasia in horses, and multicentric lymphoma remains the most common presentation of the disease. The pathogenesis of equine lymphoma is still poorly understood and the diagnosis is usually confirmed at an advanced stage of the disease, compromising the prognosis. This study investigated the clinical, pathological, and molecular features of a case of equine multicentric lymphoma. Case Description: An apparently healthy 5-year-old crossbreed mare hospitalized at the Centre of Animal Reproduction of Vairão, Portugal, suddenly presented clinical signs of supraorbital oedema and mandibular lymph node enlargement, developing fever, facial oedema, and generalized lymphadenopathy. The mare ended up dying twenty-four days after the first clinical signs due to multisystem organ failure. Haematological and biochemical analyses, necropsy, and microscopic and molecular evaluation of affected tissues were performed. At necropsy, the main findings were multiple multinodular lesions, distributed along the serous surface of oropharynx, trachea, pericardium, gastrointestinal tract, and mesentery. Microscopically, these consisted of solid proliferations of neoplastic round cells that exhibited immunopositivity for CD3 (T cells). Based on these findings, a medium-grade multicentric T-cell lymphoma was diagnosed. Conclusion: There is still very little research regarding the molecular characterization of lymphoma in horses. As an entity itself is quite heterogeneous, it is important to describe the interspecies particularities to understand its development and behaviour. [ABSTRACT FROM AUTHOR]

Published
2024
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9. Comparative epidemiological study of breast cancer in humans and canine mammary tumors: insights from Portugal.

Author

Tiago Carvalho, Paulo, Niza-Ribeiro, João, Amorim, Irina, Queiroga, Felisbina, Severo, Milton, Isabel Ribeiro, Ana, and Pinello, Katia

Subjects
BREAST cancer, METROPOLITAN areas, CLUSTER analysis (Statistics), MAMMARY glands, AGE distribution, LOBULAR carcinoma, MAST cell tumors
Abstract

Dogs spontaneously develop mammary gland tumors (MGT) and exhibit striking similarities in clinical and epidemiological characteristics to human breast cancer (HBC). Descriptive and comparative analysis of HBC and canine MGT with a focus on evaluating similarities and geographical distribution were the aims of this study. HBC cases were obtained from North Regional Oncological Registry (RORENO) (2010-2015) and canine MGT cases from Vet-OncoNet (2019-2022). Analyses were performed based on published and well accepted classification systems (ICD-O-3.2 for humans and Vet-ICD-O-canine-1). Age-standardized incidence risks (ASIR) of Porto district municipalities were calculated using 2021 Portuguese census (INE) and data from the Portuguese animal registration system (SIAC). Among 7,674 HBC cases and 1,140 MGT cases, a similar age and sex distribution pattern was observed. Approximately 69.2% of HBC cases were between 40 and 69 years old, while 66.9% of MGT cases were diagnosed between 7 and 12 years old (mean age of 9.6 years, SD = 2.6). In women, Invasive breast carcinoma (8500/3) was the most common histological type (n = 5,679, 74%) while in dogs it was the Complex Carcinoma (8983.1/3) (n = 205, 39%). Cocker and Yorkshire Terriers exhibited the highest relative risks (3.2 and 1.6, p < 0.05, respectively) when compared to cross breed dogs. The municipalities' ASIR of the two species exhibited a high correlation (R = 0.85, p < 0.01) and the spatial cluster analysis revealed similar geographic hotspots. Also, higher ASIR values both in women and dogs weremore frequently found in urbanized areas compared to rural areas. This research sheds light on the shared features and geographical correlation between HBC and canine MGT, highlighting the potential of cross-species environmental oncology studies. [ABSTRACT FROM AUTHOR]

Published
2023
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11. Allogenic Synovia-Derived Mesenchymal Stem Cells for Treatment of Equine Tendinopathies and Desmopathies—Proof of Concept

Author

Leal Reis, Inês, primary, Lopes, Bruna, additional, Sousa, Patrícia, additional, Sousa, Ana Catarina, additional, Branquinho, Mariana, additional, Caseiro, Ana Rita, additional, Pedrosa, Sílvia Santos, additional, Rêma, Alexandra, additional, Oliveira, Cláudia, additional, Porto, Beatriz, additional, Atayde, Luís, additional, Amorim, Irina, additional, Alvites, Rui, additional, Santos, Jorge Miguel, additional, and Maurício, Ana Colette, additional

Published
2023
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13. Repurposing Benztropine, Natamycin, and Nitazoxanide Using Drug Combination and Characterization of Gastric Cancer Cell Lines

Author

Ribeiro, Eduarda, primary, Araújo, Diana, additional, Pereira, Mariana, additional, Lopes, Bruna, additional, Sousa, Patrícia, additional, Sousa, Ana Catarina, additional, Coelho, André, additional, Rêma, Alexandra, additional, Alvites, Rui, additional, Faria, Fátima, additional, Oliveira, Cláudia, additional, Porto, Beatriz, additional, Maurício, Ana Colette, additional, Amorim, Irina, additional, and Vale, Nuno, additional

Published
2023
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14. Allogenic synovia-derived mesenchymal stem cells for treatment of equine tendinopathies and desmopathies — proof of concept

Author

Reis, Inês Leal, Lopes, Bruna, Sousa, Patrícia, Sousa, Ana Catarina, Branquinho, Mariana, Caseiro, Ana Rita, Pedrosa, Sílvia Santos, Rêma, Alexandra, Oliveira, Cláudia, Porto, Beatriz, Atayde, Luís, Amorim, Irina, Alvites, Rui, Santos, Jorge Miguel, Maurício, Ana Colette, and Veritati - Repositório Institucional da Universidade Católica Portuguesa

Subjects
Synovial mesenchymal stem cell, Clinical trials, Cell-based therapies, Mesenchymal stem cells, Allogenic, Ligament, Tendon, Sport horses
Abstract

Tendon and ligament injuries are frequent in sport horses and humans, and such injuries represent a significant therapeutic challenge. Tissue regeneration and function recovery are the paramount goals of tendon and ligament lesion management. Nowadays, several regenerative treatments are being developed, based on the use of stem cell and stem cell-based therapies. In the present study, the preparation of equine synovial membrane mesenchymal stem cells (eSM-MSCs) is described for clinical use, collection, transport, isolation, differentiation, characterization, and application. These cells are fibroblast-like and grow in clusters. They retain osteogenic, chondrogenic, and adipogenic differentiation potential. We present 16 clinical cases of tendonitis and desmitis, treated with allogenic eSM-MSCs and autologous serum, and we also include their evaluation, treatment, and follow-up. The concerns associated with the use of autologous serum as a vehicle are related to a reduced immunogenic response after the administration of this therapeutic combination, as well as the pro-regenerative effects from the growth factors and immunoglobulins that are part of its constitution. Most of the cases (14/16) healed in 30 days and presented good outcomes. Treatment of tendon and ligament lesions with a mixture of eSM-MSCs and autologous serum appears to be a promising clinical option for this category of lesions in equine patients.

Published
2023

17. Gamma Irradiation Processing on 3D PCL Devices—A Preliminary Biocompatibility Assessment

Author

Guedes, Fernando, primary, Branquinho, Mariana V., additional, Biscaia, Sara, additional, Alvites, Rui D., additional, Sousa, Ana C., additional, Lopes, Bruna, additional, Sousa, Patrícia, additional, Rêma, Alexandra, additional, Amorim, Irina, additional, Faria, Fátima, additional, Patrício, Tatiana M., additional, Alves, Nuno, additional, Bugalho, António, additional, and Maurício, Ana C., additional

Published
2022
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19. Vet-OncoNet: Malignancy Analysis of Neoplasms in Dogs and Cats

Author

Pinello, Katia, primary, Amorim, Irina, additional, Pires, Isabel, additional, Canadas-Sousa, Ana, additional, Catarino, José, additional, Faísca, Pedro, additional, Branco, Sandra, additional, Peleteiro, Maria C., additional, Silva, Daniela, additional, Severo, Milton, additional, and Niza-Ribeiro, João, additional

Published
2022
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23. Case Report : Fatal congenital and traumatic cervical spine injuries in a captive newborn plains zebra (Equus quagga)

Author

Silva, Gabriela Fernandes, Gomes, José Eduardo, Cunha, Raquel, Canadas-Sousa, Ana, Faria, Fátima, Baptista, Cláudia, Alvura, Nuno, Luis Miguel, Luis Miguel, and Amorim, Irina

Subjects
Fatal, Newborn, Trauma, Congenital, Zebra
Abstract

Background: In this report, we describe the clinical, macro-, and microscopic findings of a newborn zebra victim of a fatal trauma and its possible causes are discussed in detail.Case Description: A plains zebra (Equus quagga) born in a Portuguese zoo was found in hypothermia and unable to get up. The animal was admitted to the hospital 36 hours later and, after the first hour of treatment and no attempts to get up, it began to convulse and died. At necropsy, subdural hematoma and atlantoaxial dislocation were the main findings.Conclusion: The inability to pinpoint the exact moment of the lesions’ onset determines the importance of a thorough surveillance of the periparturient period and parturition of captive animals. Furthermore, literature concerning zebras, their reproduction, and neonatal period is scarce, reinforcing the need to report these cases.

Published
2022

26. Helicobacter spp. in the Stomach of Cats: Successful Colonization and Absence of Relevant Histopathological Alterations Reveals High Adaptation to the Host Gastric Niche

Author

Teixeira, Sílvia, primary, Filipe, Dulce, additional, Cerqueira, Manuela, additional, Barradas, Patrícia, additional, Cortez Nunes, Francisco, additional, Faria, Fátima, additional, Haesebrouck, Freddy, additional, Mesquita, João R., additional, Gärtner, Fátima, additional, and Amorim, Irina, additional

Published
2022
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28. sj-pdf-1-vet-10.1177_03009858221117858 – Supplemental material for Vimentin and Ki-67 immunolabeling in canine gastric carcinomas and their prognostic value

Author

Flores, Ana R., Rêma, Alexandra, Mesquita, João R., Taulescu, Marian, Seixas, Fernanda, Gärtner, Fátima, and Amorim, Irina

Subjects
70706 Veterinary Medicine, FOS: Clinical medicine, FOS: Veterinary sciences, 111599 Pharmacology and Pharmaceutical Sciences not elsewhere classified
Abstract

Supplemental material, sj-pdf-1-vet-10.1177_03009858221117858 for Vimentin and Ki-67 immunolabeling in canine gastric carcinomas and their prognostic value by Ana R. Flores, Alexandra Rêma, João R. Mesquita, Marian Taulescu, Fernanda Seixas, Fátima Gärtner and Irina Amorim in Veterinary Pathology

Published
2022
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29. Additional file 1 of Molecular detection of Helicobacter spp. and Fusobacterium gastrosuis in pigs and wild boars and its association with gastric histopathological alterations

Author

Cortez Nunes, Francisco, Letra Mateus, Teresa, Taillieu, Emily, Teixeira, Sílvia, Carolino, Nuno, Rema, Alexandra, De Bruyckere, Sofie, Gärtner, Fátima, Haesebrouck, Freddy, and Amorim, Irina

Abstract

Additional file 1. Primer sequences used for detection of Helicobacter spp. and F. gastrosuis and thermocycling conditions.

Published
2022
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30. Additional file 2 of Retrospective study of canine cutaneous tumors submitted to a diagnostic pathology laboratory in Northern Portugal (2014���2020)

Author

Martins, Ana Lu��sa, Canadas-Sousa, Ana, Mesquita, Jo��o R., Dias-Pereira, Patr��cia, Amorim, Irina, and G��rtner, F��tima

Abstract

Additional file 2: Table S1. Number (n) and frequency (%) of the breeds from the Canine population in the database, 2014-2020 used in the calculations for occurrence within breed. Table S2. Binary logistic regression analysis showing the association of cutaneous tumors development with age. sex. and specific breed

Published
2022
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32. Additional file 2 of Molecular detection of Helicobacter spp. and Fusobacterium gastrosuis in pigs and wild boars and its association with gastric histopathological alterations

Author

Cortez Nunes, Francisco, Letra Mateus, Teresa, Taillieu, Emily, Teixeira, Sílvia, Carolino, Nuno, Rema, Alexandra, De Bruyckere, Sofie, Gärtner, Fátima, Haesebrouck, Freddy, and Amorim, Irina

Abstract

Additional file 2. Nonparametric Kruskal–Wallis, Chi Square test applied to the three gastric zones comparing the different variables in pigs.

Published
2022
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33. Additional file 3 of Molecular detection of Helicobacter spp. and Fusobacterium gastrosuis in pigs and wild boars and its association with gastric histopathological alterations

Author

Cortez Nunes, Francisco, Letra Mateus, Teresa, Taillieu, Emily, Teixeira, Sílvia, Carolino, Nuno, Rema, Alexandra, De Bruyckere, Sofie, Gärtner, Fátima, Haesebrouck, Freddy, and Amorim, Irina

Abstract

Additional file 3. BLAST identity percentage interval of the different Helicobacter spp. and F. gastrosuis sequences obtained.

Published
2022
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34. Additional file 4 of Molecular detection of Helicobacter spp. and Fusobacterium gastrosuis in pigs and wild boars and its association with gastric histopathological alterations

Author

Cortez Nunes, Francisco, Letra Mateus, Teresa, Taillieu, Emily, Teixeira, Sílvia, Carolino, Nuno, Rema, Alexandra, De Bruyckere, Sofie, Gärtner, Fátima, Haesebrouck, Freddy, and Amorim, Irina

Abstract

Additional file 4. Number of Helicobacter spp. and F. gastrosuis DNA positive samples associated with gastritis score per pig gastric zone.

Published
2022
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35. Presence of Helicobacter Species in Gastric Mucosa of Human Patients and Outcome of Helicobacter Eradication Treatment

Author

Matos, Rita, primary, Taillieu, Emily, additional, De Bruyckere, Sofie, additional, De Witte, Chloë, additional, Rêma, Alexandra, additional, Santos-Sousa, Hugo, additional, Nogueiro, Jorge, additional, Reis, Celso A., additional, Carneiro, Fátima, additional, Haesebrouck, Freddy, additional, Amorim, Irina, additional, and Gärtner, Fátima, additional

Published
2022
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38. Closure of defects in a geometric figure pattern associated with tumescent anesthesia with lidocaine in rabbits (Oryctolagus cuniculus)

Author

Serafim, Eduardo Luís, primary, Pazzini, Josiane Morais, additional, Rocha, Michelle do Carmo Pereira, additional, Linhares, Laís Calazans Menescal, additional, Nardi, Andrigo Barboza de, additional, Gartner, Maria de Fátima Moutinho, additional, Amorim, Irina, additional, Rema, Alexandra, additional, Faria, Fátima, additional, Uscategui, Ricardo Andres Ramirez, additional, Almeida, Vivian Tavares de, additional, Calpaa, Carlos Alfredo, additional, and Calazans, Sabrina Gouveia, additional

Published
2022
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39. Repurposed Drugs in Gastric Cancer.

Author

Araújo, Diana, Ribeiro, Eduarda, Amorim, Irina, and Vale, Nuno

Subjects
STOMACH cancer, ANTINEOPLASTIC agents, DRUG repositioning, DRUG development, CANCER-related mortality
Abstract

Gastric cancer (GC) is one of the major causes of death worldwide, ranking as the fifth most incident cancer in 2020 and the fourth leading cause of cancer mortality. The majority of GC patients are in an advanced stage at the time of diagnosis, presenting a poor prognosis and outcome. Current GC treatment approaches involve endoscopic detection, gastrectomy and chemotherapy or chemoradiotherapy in an adjuvant or neoadjuvant setting. Drug development approaches demand extreme effort to identify molecular mechanisms of action of new drug candidates. Drug repurposing is based on the research of new therapeutic indications of drugs approved for other pathologies. In this review, we explore GC and the different drugs repurposed for this disease. [ABSTRACT FROM AUTHOR]

Published
2023
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44. In Vitro and In Vivo Characterization of PLLA-316L Stainless Steel Electromechanical Devices for Bone Tissue Engineering—A Preliminary Study

Author

Branquinho, Mariana V., primary, Ferreira, Sheila O., additional, Alvites, Rui D., additional, Magueta, Adriana F., additional, Ivanov, Maxim, additional, Sousa, Ana Catarina, additional, Amorim, Irina, additional, Faria, Fátima, additional, Fernandes, M. H. V., additional, Vilarinho, Paula M., additional, and Maurício, Ana Colette, additional

Published
2021
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49. A 2-Year Longitudinal Seroepidemiological Evaluation of Toxoplasma gondii Antibodies in a Cohort of Autochthonous Sheep from Central Portugal

Author

Almeida, Daniela, primary, Quirino, João, additional, Barradas, Patrícia Ferreira, additional, da Silva, Priscilla Gomes, additional, Pereira, Maria, additional, Cruz, Rita, additional, Santos, Carla, additional, Mega, Ana Cristina, additional, Esteves, Fernando, additional, Nóbrega, Carmen, additional, Vala, Helena, additional, Gärtner, Fátima, additional, Amorim, Irina, additional, and Mesquita, João R., additional

Published
2021
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50. Combined Use of Chitosan and Olfactory Mucosa Mesenchymal Stem/Stromal Cells to Promote Peripheral Nerve Regeneration In Vivo

Author

Alvites, Rui D., primary, Branquinho, Mariana V., additional, Sousa, Ana C., additional, Amorim, Irina, additional, Magalhães, Rui, additional, João, Filipa, additional, Almeida, Diogo, additional, Amado, Sandra, additional, Prada, Justina, additional, Pires, Isabel, additional, Zen, Federica, additional, Raimondo, Stefania, additional, Luís, Ana L., additional, Geuna, Stefano, additional, Varejão, Artur S. P., additional, and Maurício, Ana C., additional

Published
2021
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