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3. Tubuloid differentiation to model the human distal nephron and collecting duct in health and disease

Author

Nefro Vasculaire Geneeskunde, AIOS Psychiatrie, Regenerative Medicine and Stem Cells, Circulatory Health, Cancer, CMM, Hubrecht Institute with UMC, Yousef Yengej, Fjodor A, Pou Casellas, Carla, Ammerlaan, Carola M E, Olde Hanhof, Charlotte J A, Dilmen, Emre, Beumer, Joep, Begthel, Harry, Meeder, Elise M G, Hoenderop, Joost G, Rookmaaker, Maarten B, Verhaar, Marianne C, Clevers, Hans, Nefro Vasculaire Geneeskunde, AIOS Psychiatrie, Regenerative Medicine and Stem Cells, Circulatory Health, Cancer, CMM, Hubrecht Institute with UMC, Yousef Yengej, Fjodor A, Pou Casellas, Carla, Ammerlaan, Carola M E, Olde Hanhof, Charlotte J A, Dilmen, Emre, Beumer, Joep, Begthel, Harry, Meeder, Elise M G, Hoenderop, Joost G, Rookmaaker, Maarten B, Verhaar, Marianne C, and Clevers, Hans

Published
2024

4. Cysteamine–bicalutamide combination therapy corrects proximal tubule phenotype in cystinosis

Author

Jamalpoor, Amer, van Gelder, Charlotte AGH, Yousef Yengej, Fjodor A, Zaal, Esther A, Berlingerio, Sante P, Veys, Koenraad R, Pou Casellas, Carla, Voskuil, Koen, Essa, Khaled, Ammerlaan, Carola ME, Rega, Laura Rita, van der Welle, Reini EN, Lilien, Marc R, Rookmaaker, Maarten B, Clevers, Hans, Klumperman, Judith, Levtchenko, Elena, Berkers, Celia R, Verhaar, Marianne C, Altelaar, Maarten, Masereeuw, Rosalinde, and Janssen, Manoe J

Published
2021
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5. Tubuloids derived from human adult kidney and urine for personalized disease modeling

Author

Schutgens, Frans, Rookmaaker, Maarten B, Margaritis, Thanasis, Rios, Anne, Ammerlaan, Carola, Jansen, Jitske, Gijzen, Linda, Vormann, Marianne, Vonk, Annelotte, Viveen, Marco, Yengej, Fjodor Yousef, Derakhshan, Sepide, de Winter-de Groot, Karin M., Artegiani, Benedetta, van Boxtel, Ruben, Cuppen, Edwin, Hendrickx, Antoni P. A., van den Heuvel-Eibrink, Marry M., Heitzer, Ellen, Lanz, Henriette, Beekman, Jeffrey, Murk, Jean-Luc, Masereeuw, Rosalinde, Holstege, Frank, Drost, Jarno, Verhaar, Marianne C, and Clevers, Hans

Published
2019
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6. An organoid biobank for childhood kidney cancers that captures disease and tissue heterogeneity

Author

Calandrini, Camilla, Schutgens, Frans, Oka, Rurika, Margaritis, Thanasis, Candelli, Tito, Mathijsen, Luka, Ammerlaan, Carola, van Ineveld, Ravian L., Derakhshan, Sepide, de Haan, Sanne, Dolman, Emmy, Lijnzaad, Philip, Custers, Lars, Begthel, Harry, Kerstens, Hindrik H. D., Visser, Lindy L., Rookmaaker, Maarten, Verhaar, Marianne, Tytgat, Godelieve A. M., Kemmeren, Patrick, de Krijger, Ronald R., Al-Saadi, Reem, Pritchard-Jones, Kathy, Kool, Marcel, Rios, Anne C., van den Heuvel-Eibrink, Marry M., Molenaar, Jan J., van Boxtel, Ruben, Holstege, Frank C. P., Clevers, Hans, and Drost, Jarno

Published
2020
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7. Tubuloid culture enables long-term expansion of functional human kidney tubule epithelium from iPSC-derived organoids

Author

Yengej, Fjodor A. Yousef, Jansen, Jitske, Ammerlaan, Carola M. E., Dilmen, Emre, Casellas, Carla Pou, Masereeuw, Rosalinde, Hoenderop, Joost G., Smeets, Bart, Rookmaaker, Maarten B., Verhaar, Marianne C., Clevers, Hans, Yengej, Fjodor A. Yousef, Jansen, Jitske, Ammerlaan, Carola M. E., Dilmen, Emre, Casellas, Carla Pou, Masereeuw, Rosalinde, Hoenderop, Joost G., Smeets, Bart, Rookmaaker, Maarten B., Verhaar, Marianne C., and Clevers, Hans

Abstract

Kidney organoids generated from induced pluripotent stem cells (iPSC) have proven valuable for studies of kidney development, disease, and therapeutic screening. However, specific applications have been hampered by limited expansion capacity, immaturity, off-target cells, and inability to access the apical side. Here, we apply recently developed tubuloid protocols to purify and propagate kidney epithelium from d7+18 (post nephrogenesis) iPSC-derived organoids. The resulting ‘iPSC organoid-derived (iPSCod)’ tubuloids can be exponentially expanded for at least 2.5 mo, while retaining expression of important tubular transporters and segment-specific markers. This approach allows for selective propagation of the mature tubular epithelium, as immature cells, stroma, and undesirable off-target cells rapidly disappeared. iPSCod tubuloids provide easy apical access, which enabled functional evaluation and demonstration of essential secretion and electrolyte reabsorption processes. In conclusion, iPSCod tubuloids provide a different, complementary human kidney model that unlocks opportunities for functional characterization, disease modeling, and regenerative nephrology.

Published
2023

8. Tubuloid culture enables long-term expansion of functional human kidney tubule epithelium from iPSC-derived organoids

Author

Afd Pharmacology, Pharmacology, Yengej, Fjodor A. Yousef, Jansen, Jitske, Ammerlaan, Carola M. E., Dilmen, Emre, Casellas, Carla Pou, Masereeuw, Rosalinde, Hoenderop, Joost G., Smeets, Bart, Rookmaaker, Maarten B., Verhaar, Marianne C., Clevers, Hans, Afd Pharmacology, Pharmacology, Yengej, Fjodor A. Yousef, Jansen, Jitske, Ammerlaan, Carola M. E., Dilmen, Emre, Casellas, Carla Pou, Masereeuw, Rosalinde, Hoenderop, Joost G., Smeets, Bart, Rookmaaker, Maarten B., Verhaar, Marianne C., and Clevers, Hans

Published
2023

9. Tubuloid culture enables long-term expansion of functional human kidney tubule epithelium from iPSC-derived organoids

Author

Yousef Yengej, Fjodor A, Jansen, Jitske, Ammerlaan, Carola M E, Dilmen, Emre, Pou Casellas, Carla, Masereeuw, Rosalinde, Hoenderop, Joost G, Smeets, Bart, Rookmaaker, Maarten B, Verhaar, Marianne C, Clevers, Hans, Yousef Yengej, Fjodor A, Jansen, Jitske, Ammerlaan, Carola M E, Dilmen, Emre, Pou Casellas, Carla, Masereeuw, Rosalinde, Hoenderop, Joost G, Smeets, Bart, Rookmaaker, Maarten B, Verhaar, Marianne C, and Clevers, Hans

Abstract

Kidney organoids generated from induced pluripotent stem cells (iPSC) have proven valuable for studies of kidney development, disease, and therapeutic screening. However, specific applications have been hampered by limited expansion capacity, immaturity, off-target cells, and inability to access the apical side. Here, we apply recently developed tubuloid protocols to purify and propagate kidney epithelium from d7+18 (post nephrogenesis) iPSC-derived organoids. The resulting 'iPSC organoid-derived (iPSCod)' tubuloids can be exponentially expanded for at least 2.5 mo, while retaining expression of important tubular transporters and segment-specific markers. This approach allows for selective propagation of the mature tubular epithelium, as immature cells, stroma, and undesirable off-target cells rapidly disappeared. iPSCod tubuloids provide easy apical access, which enabled functional evaluation and demonstration of essential secretion and electrolyte reabsorption processes. In conclusion, iPSCod tubuloids provide a different, complementary human kidney model that unlocks opportunities for functional characterization, disease modeling, and regenerative nephrology.

Published
2023

10. Tubuloid culture enables long-term expansion of functional human kidney tubule epithelium from iPSC-derived organoids

Author

Nefro Vasculaire Geneeskunde, MS Nefrologie, Regenerative Medicine and Stem Cells, Circulatory Health, CMM, Cancer, Hubrecht Institute with UMC, Yousef Yengej, Fjodor A., Jansen, Jitske, Ammerlaan, Carola M.E., Dilmen, Emre, Casellas, Carla Pou, Masereeuw, Rosalinde, Hoenderop, Joost G., Smeets, Bart, Rookmaaker, Maarten B., Verhaar, Marianne C., Clevers, Hans, Nefro Vasculaire Geneeskunde, MS Nefrologie, Regenerative Medicine and Stem Cells, Circulatory Health, CMM, Cancer, Hubrecht Institute with UMC, Yousef Yengej, Fjodor A., Jansen, Jitske, Ammerlaan, Carola M.E., Dilmen, Emre, Casellas, Carla Pou, Masereeuw, Rosalinde, Hoenderop, Joost G., Smeets, Bart, Rookmaaker, Maarten B., Verhaar, Marianne C., and Clevers, Hans

Published
2023

11. Tubuloid culture enables long-term expansion of functional human kidney tubule epithelium from iPSC-derived organoids

Author

Yousef Yengej, Fjodor A., primary, Jansen, Jitske, additional, Ammerlaan, Carola M. E., additional, Dilmen, Emre, additional, Pou Casellas, Carla, additional, Masereeuw, Rosalinde, additional, Hoenderop, Joost G., additional, Smeets, Bart, additional, Rookmaaker, Maarten B., additional, Verhaar, Marianne C., additional, and Clevers, Hans, additional

Published
2023
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12. Differentiated kidney tubular cell-derived extracellular vesicles enhance maturation of tubuloids

Author

Soares Lindoso, Rafaël, Yousef Yengej, Fjodor A., Völlmy, Franziska, Altelaar, Maarten, Juncosa, Estela Mancheno, Tsikari, Theano, Ammerlaan, Carola M.E., van Balkom, B, Rookmaaker, M.B., Verhaar, M.C., Masereeuw, Rosalinde, Soares Lindoso, Rafaël, Yousef Yengej, Fjodor A., Völlmy, Franziska, Altelaar, Maarten, Juncosa, Estela Mancheno, Tsikari, Theano, Ammerlaan, Carola M.E., van Balkom, B, Rookmaaker, M.B., Verhaar, M.C., and Masereeuw, Rosalinde

Abstract

The prevalence of end-stage kidney disease (ESKD) is rapidly increasing with the need for regenerative therapies. Adult stem cell derived kidney tubuloids have the potential to functionally mimic the adult kidney tubule, but still lack the expression of important transport proteins needed for waste removal. Here, we investigated the potential of extracellular vesicles (EVs) obtained from matured kidney tubular epithelial cells to modulate in vitro tubuloids functional maturation. We focused on organic anion transporter 1 (OAT1), one of the most important proteins involved in endogenous waste excretion. First, we show that EVs from engineered proximal tubule cells increased the expression of several transcription factors and epithelial transporters, resulting in improved OAT1 transport capacity. Next, a more in-depth proteomic data analysis showed that EVs can trigger various biological pathways, including mesenchymal-to-epithelial transition, which is crucial in the tubular epithelial maturation. Moreover, we demonstrated that the combination of EVs and tubuloid-derived cells can be used as part of a bioartificial kidney to generate a tight polarized epithelial monolayer with formation of dense cilia structures. In conclusion, EVs from kidney tubular epithelial cells can phenotypically improve in vitro tubuloid maturation, thereby enhancing their potential as functional units in regenerative or renal replacement therapies. Graphical Abstract: [Figure not available: see fulltext.].

Published
2022

13. Differentiated kidney tubular cell-derived extracellular vesicles enhance maturation of tubuloids

Author

Afd Pharmacology, Afd Biomol.Mass Spect. and Proteomics, Pharmacology, Biomolecular Mass Spectrometry and Proteomics, Lindoso, Rafael Soares, Yengej, Fjodor A. Yousef, Voellmy, Franziska, Altelaar, Maarten, Juncosa, Estela Mancheno, Tsikari, Theano, Ammerlaan, Carola M.E., Balkom, Bas W.M. Van, Verhaar, Marianne C., Masereeuw, Rosalinde, Afd Pharmacology, Afd Biomol.Mass Spect. and Proteomics, Pharmacology, Biomolecular Mass Spectrometry and Proteomics, Lindoso, Rafael Soares, Yengej, Fjodor A. Yousef, Voellmy, Franziska, Altelaar, Maarten, Juncosa, Estela Mancheno, Tsikari, Theano, Ammerlaan, Carola M.E., Balkom, Bas W.M. Van, Verhaar, Marianne C., and Masereeuw, Rosalinde

Published
2022

14. R-spondin-3 is an oncogenic driver of poorly differentiated invasive breast cancer

Author

Pathologie Groep Derksen, Nefro Vasculaire Geneeskunde, Cancer, Ter Steege, Eline J, Boer, Mandy, Timmer, Nikki C, Ammerlaan, Carola Me, Song, Ji-Ying, Derksen, Patrick Wb, Hilkens, John, Bakker, Elvira Rm, Pathologie Groep Derksen, Nefro Vasculaire Geneeskunde, Cancer, Ter Steege, Eline J, Boer, Mandy, Timmer, Nikki C, Ammerlaan, Carola Me, Song, Ji-Ying, Derksen, Patrick Wb, Hilkens, John, and Bakker, Elvira Rm

Published
2022

15. Differentiated kidney tubular cell-derived extracellular vesicles enhance maturation of tubuloids

Author

Nefro Vasculaire Geneeskunde, MS Nefrologie, Circulatory Health, Regenerative Medicine and Stem Cells, Lindoso, Rafael Soares, Yousef Yengej, Fjodor A., Voellmy, Franziska, Altelaar, Maarten, Mancheño Juncosa, Estela, Tsikari, Theano, Ammerlaan, Carola M.E., Van Balkom, Bas W.M., Rookmaaker, Maarten B., Verhaar, Marianne C., Masereeuw, Rosalinde, Nefro Vasculaire Geneeskunde, MS Nefrologie, Circulatory Health, Regenerative Medicine and Stem Cells, Lindoso, Rafael Soares, Yousef Yengej, Fjodor A., Voellmy, Franziska, Altelaar, Maarten, Mancheño Juncosa, Estela, Tsikari, Theano, Ammerlaan, Carola M.E., Van Balkom, Bas W.M., Rookmaaker, Maarten B., Verhaar, Marianne C., and Masereeuw, Rosalinde

Published
2022

18. Cysteamine–bicalutamide combination therapy corrects proximal tubule phenotype in cystinosis

Author

Afd Pharmacology, Afd Biomol.Mass Spect. and Proteomics, Veterinaire biochemie, Dep Scheikunde, Faculteit Diergeneeskunde, Sub Biomol.Mass Spectrometry & Proteom., dB&C FR-RMSC RMSC, Pharmacology, Biomolecular Mass Spectrometry and Proteomics, Jamalpoor, Amer, van Gelder, Charlotte A.G.H., Yousef Yengej, Fjodor A., Zaal, Esther A., Berlingerio, Sante P., Veys, Koenraad R., Pou Casellas, Carla, Voskuil, Koen, Essa, Khaled, Ammerlaan, Carola M.E., Rega, Laura Rita, van der Welle, Reini E.N., Lilien, Marc R., Rookmaaker, Maarten B., Clevers, Hans, Klumperman, Judith, Levtchenko, Elena, Berkers, Celia R., Verhaar, Marianne C., Altelaar, Maarten, Masereeuw, Rosalinde, Janssen, Manoe J., Afd Pharmacology, Afd Biomol.Mass Spect. and Proteomics, Veterinaire biochemie, Dep Scheikunde, Faculteit Diergeneeskunde, Sub Biomol.Mass Spectrometry & Proteom., dB&C FR-RMSC RMSC, Pharmacology, Biomolecular Mass Spectrometry and Proteomics, Jamalpoor, Amer, van Gelder, Charlotte A.G.H., Yousef Yengej, Fjodor A., Zaal, Esther A., Berlingerio, Sante P., Veys, Koenraad R., Pou Casellas, Carla, Voskuil, Koen, Essa, Khaled, Ammerlaan, Carola M.E., Rega, Laura Rita, van der Welle, Reini E.N., Lilien, Marc R., Rookmaaker, Maarten B., Clevers, Hans, Klumperman, Judith, Levtchenko, Elena, Berkers, Celia R., Verhaar, Marianne C., Altelaar, Maarten, Masereeuw, Rosalinde, and Janssen, Manoe J.

Published
2021

19. Culture and analysis of kidney tubuloids and perfused tubuloid cells-on-a-chip

Author

Gijzen, Linda, Yousef Yengej, Fjodor A, Schutgens, Frans, Vormann, Marianne K, Ammerlaan, Carola M E, Nicolas, Arnaud, Kurek, Dorota, Vulto, Paul, Rookmaaker, Maarten B, Lanz, Henriette L, Verhaar, Marianne C, Clevers, Hans, Gijzen, Linda, Yousef Yengej, Fjodor A, Schutgens, Frans, Vormann, Marianne K, Ammerlaan, Carola M E, Nicolas, Arnaud, Kurek, Dorota, Vulto, Paul, Rookmaaker, Maarten B, Lanz, Henriette L, Verhaar, Marianne C, and Clevers, Hans

Abstract

Advanced in vitro kidney models are of great importance to the study of renal physiology and disease. Kidney tubuloids can be established from primary cells derived from adult kidney tissue or urine. Tubuloids are three-dimensional multicellular structures that recapitulate tubular function and have been used to study infectious, malignant, metabolic, and genetic diseases. For tubuloids to more closely represent the in vivo kidney, they can be integrated into an organ-on-a-chip system that has a more physiological tubular architecture and allows flow and interaction with vasculature or epithelial and mesenchymal cells from other organs. Here, we describe a detailed protocol for establishing tubuloid cultures from tissue and urine (1-3 weeks), as well as for generating and characterizing tubuloid cell-derived three-dimensional tubular structures in a perfused microfluidic multi-chip platform (7 d). The combination of the two systems yields a powerful in vitro tool that better recapitulates the complexity of the kidney tubule with donor-specific properties.

Published
2021

20. Culture and analysis of kidney tubuloids and perfused tubuloid cells-on-a-chip

Author

Nefro Vasculaire Geneeskunde, MS Nefrologie, Circulatory Health, Regenerative Medicine and Stem Cells, CMM Sectie Molecular Cancer Research, Child Health, Cancer, Hubrecht Institute with UMC, Gijzen, Linda, Yousef Yengej, Fjodor A, Schutgens, Frans, Vormann, Marianne K, Ammerlaan, Carola M E, Nicolas, Arnaud, Kurek, Dorota, Vulto, Paul, Rookmaaker, Maarten B, Lanz, Henriette L, Verhaar, Marianne C, Clevers, Hans, Nefro Vasculaire Geneeskunde, MS Nefrologie, Circulatory Health, Regenerative Medicine and Stem Cells, CMM Sectie Molecular Cancer Research, Child Health, Cancer, Hubrecht Institute with UMC, Gijzen, Linda, Yousef Yengej, Fjodor A, Schutgens, Frans, Vormann, Marianne K, Ammerlaan, Carola M E, Nicolas, Arnaud, Kurek, Dorota, Vulto, Paul, Rookmaaker, Maarten B, Lanz, Henriette L, Verhaar, Marianne C, and Clevers, Hans

Published
2021

21. An organoid biobank for childhood kidney cancers that captures disease and tissue heterogeneity

Author

UU BETA RESEARCH, Faculteit Diergeneeskunde, Calandrini, Camilla, Schutgens, Frans, Oka, Rurika, Margaritis, Thanasis, Candelli, Tito, Mathijsen, Luka, Ammerlaan, Carola, van Ineveld, Ravian L, Derakhshan, Sepide, de Haan, Sanne, Dolman, Emmy, Lijnzaad, Philip, Custers, Lars, Begthel, Harry, Kerstens, Hindrik H D, Visser, Lindy L, Rookmaaker, Maarten, Verhaar, Marianne, Tytgat, Godelieve A M, Kemmeren, Patrick, de Krijger, Ronald R, Al-Saadi, Reem, Pritchard-Jones, Kathy, Kool, Marcel, Rios, Anne C, van den Heuvel-Eibrink, Marry M, Molenaar, Jan J, van Boxtel, Ruben, Holstege, Frank C P, Clevers, Hans, Drost, Jarno, UU BETA RESEARCH, Faculteit Diergeneeskunde, Calandrini, Camilla, Schutgens, Frans, Oka, Rurika, Margaritis, Thanasis, Candelli, Tito, Mathijsen, Luka, Ammerlaan, Carola, van Ineveld, Ravian L, Derakhshan, Sepide, de Haan, Sanne, Dolman, Emmy, Lijnzaad, Philip, Custers, Lars, Begthel, Harry, Kerstens, Hindrik H D, Visser, Lindy L, Rookmaaker, Maarten, Verhaar, Marianne, Tytgat, Godelieve A M, Kemmeren, Patrick, de Krijger, Ronald R, Al-Saadi, Reem, Pritchard-Jones, Kathy, Kool, Marcel, Rios, Anne C, van den Heuvel-Eibrink, Marry M, Molenaar, Jan J, van Boxtel, Ruben, Holstege, Frank C P, Clevers, Hans, and Drost, Jarno

Published
2020

22. Cysteamine-bicalutamide combination treatment restores alpha-ketoglutarate and corrects proximal tubule phenotype in cystinosis

Author

Afd Pharmacology, Afd Biomol.Mass Spect. and Proteomics, Dep Scheikunde, Veterinaire biochemie, dB&C FR-RMSC RMSC, Sub Biomol.Mass Spectrometry & Proteom., Pharmacology, Biomolecular Mass Spectrometry and Proteomics, Jamalpoor, A., van Gelder, C.A.G.H., Yousef Yengej, Fjodor A., Zaal, E.A., Berlingerio, Sante Princiero, Veys, Koenraad R., Pou Casellas, C., Voskuil, Koen, Essa, Khaled, Ammerlaan, Carola, Rega, Laura Rita, van der Welle, Reini, Lilien, M.R., Rookmaaker, M.B., Clevers, H.C., Klumperman, J., Levtchenko, Elena, Berkers, C.R., Verhaar, Marianne C, Altelaar, A.F.M., Masereeuw, Rosalinde, Janssen, M.J., Afd Pharmacology, Afd Biomol.Mass Spect. and Proteomics, Dep Scheikunde, Veterinaire biochemie, dB&C FR-RMSC RMSC, Sub Biomol.Mass Spectrometry & Proteom., Pharmacology, Biomolecular Mass Spectrometry and Proteomics, Jamalpoor, A., van Gelder, C.A.G.H., Yousef Yengej, Fjodor A., Zaal, E.A., Berlingerio, Sante Princiero, Veys, Koenraad R., Pou Casellas, C., Voskuil, Koen, Essa, Khaled, Ammerlaan, Carola, Rega, Laura Rita, van der Welle, Reini, Lilien, M.R., Rookmaaker, M.B., Clevers, H.C., Klumperman, J., Levtchenko, Elena, Berkers, C.R., Verhaar, Marianne C, Altelaar, A.F.M., Masereeuw, Rosalinde, and Janssen, M.J.

Published
2020

23. An organoid biobank for childhood kidney cancers that captures disease and tissue heterogeneity

Author

Nefro Vasculaire Geneeskunde, Groep Holstege, CMM Groep Klumperman, MS Nefrologie, Regenerative Medicine and Stem Cells, Circulatory Health, Pathologie Groep Blokx, Pathologie Pathologen staf, Child Health, CMM Groep Cuppen, Cancer, CMM Sectie Molecular Cancer Research, Hubrecht Institute with UMC, Calandrini, Camilla, Schutgens, Frans, Oka, Rurika, Margaritis, Thanasis, Candelli, Tito, Mathijsen, Luka, Ammerlaan, Carola, van Ineveld, Ravian L., Derakhshan, Sepide, de Haan, Sanne, Dolman, Emmy, Lijnzaad, Philip, Custers, Lars, Begthel, Harry, Kerstens, Hindrik H.D., Visser, Lindy L., Rookmaaker, Maarten, Verhaar, Marianne, Tytgat, Godelieve A.M., Kemmeren, Patrick, de Krijger, Ronald R., Al-Saadi, Reem, Pritchard-Jones, Kathy, Kool, Marcel, Rios, Anne C., van den Heuvel-Eibrink, Marry M., Molenaar, Jan J., van Boxtel, Ruben, Holstege, Frank C.P., Clevers, Hans, Drost, Jarno, Nefro Vasculaire Geneeskunde, Groep Holstege, CMM Groep Klumperman, MS Nefrologie, Regenerative Medicine and Stem Cells, Circulatory Health, Pathologie Groep Blokx, Pathologie Pathologen staf, Child Health, CMM Groep Cuppen, Cancer, CMM Sectie Molecular Cancer Research, Hubrecht Institute with UMC, Calandrini, Camilla, Schutgens, Frans, Oka, Rurika, Margaritis, Thanasis, Candelli, Tito, Mathijsen, Luka, Ammerlaan, Carola, van Ineveld, Ravian L., Derakhshan, Sepide, de Haan, Sanne, Dolman, Emmy, Lijnzaad, Philip, Custers, Lars, Begthel, Harry, Kerstens, Hindrik H.D., Visser, Lindy L., Rookmaaker, Maarten, Verhaar, Marianne, Tytgat, Godelieve A.M., Kemmeren, Patrick, de Krijger, Ronald R., Al-Saadi, Reem, Pritchard-Jones, Kathy, Kool, Marcel, Rios, Anne C., van den Heuvel-Eibrink, Marry M., Molenaar, Jan J., van Boxtel, Ruben, Holstege, Frank C.P., Clevers, Hans, and Drost, Jarno

Published
2020

24. Tubuloids derived from human adult kidney and urine for personalized disease modeling

Author

Afd Pharmacology, Sub Developmental Biology, Faculteit Diergeneeskunde, Pharmacology, Schutgens, Frans, Rookmaaker, Maarten B, Margaritis, Thanasis, Rios, Anne, Ammerlaan, Carola, Jansen, Jitske, Gijzen, Linda, Vormann, Marianne, Vonk, Annelotte, Viveen, Marco, Yengej, Fjodor Yousef, Derakhshan, Sepide, de Winter-de Groot, Karin M, Artegiani, Benedetta, van Boxtel, Ruben, Cuppen, Edwin, Hendrickx, Antoni P A, van den Heuvel-Eibrink, Marry M, Heitzer, Ellen, Lanz, Henriette, Beekman, Jeffrey, Murk, Jean-Luc, Masereeuw, Rosalinde, Holstege, Frank, Drost, Jarno, Verhaar, Marianne C, Clevers, Hans, Afd Pharmacology, Sub Developmental Biology, Faculteit Diergeneeskunde, Pharmacology, Schutgens, Frans, Rookmaaker, Maarten B, Margaritis, Thanasis, Rios, Anne, Ammerlaan, Carola, Jansen, Jitske, Gijzen, Linda, Vormann, Marianne, Vonk, Annelotte, Viveen, Marco, Yengej, Fjodor Yousef, Derakhshan, Sepide, de Winter-de Groot, Karin M, Artegiani, Benedetta, van Boxtel, Ruben, Cuppen, Edwin, Hendrickx, Antoni P A, van den Heuvel-Eibrink, Marry M, Heitzer, Ellen, Lanz, Henriette, Beekman, Jeffrey, Murk, Jean-Luc, Masereeuw, Rosalinde, Holstege, Frank, Drost, Jarno, Verhaar, Marianne C, and Clevers, Hans

Published
2019

25. Tubuloids derived from human adult kidney and urine for personalized disease modeling

Author

Regenerative Medicine and Stem Cells, MS Nefrologie, Groep Holstege, Nefro Vasculaire Geneeskunde, Longziekten patientenzorg, Child Health, CMM Groep Cuppen, CMM, Infection & Immunity, Speerpunt, Zorg en O&O, Longziekten onderzoek 2, Onderzoek, MMB Medische Staf, CMM Groep Burgering, Cancer, Circulatory Health, CMM Sectie Molecular Cancer Research, Hubrecht Institute with UMC, Schutgens, Frans, Rookmaaker, Maarten B, Margaritis, Thanasis, Rios, Anne, Ammerlaan, Carola, Jansen, Jitske, Gijzen, Linda, Vormann, Marianne, Vonk, Annelotte, Viveen, Marco, Yengej, Fjodor Yousef, Derakhshan, Sepide, de Winter-de Groot, Karin M, Artegiani, Benedetta, van Boxtel, Ruben, Cuppen, Edwin, Hendrickx, Antoni P A, van den Heuvel-Eibrink, Marry M, Heitzer, Ellen, Lanz, Henriette, Beekman, Jeffrey, Murk, Jean-Luc, Masereeuw, Rosalinde, Holstege, Frank, Drost, Jarno, Verhaar, Marianne C, Clevers, Hans, Regenerative Medicine and Stem Cells, MS Nefrologie, Groep Holstege, Nefro Vasculaire Geneeskunde, Longziekten patientenzorg, Child Health, CMM Groep Cuppen, CMM, Infection & Immunity, Speerpunt, Zorg en O&O, Longziekten onderzoek 2, Onderzoek, MMB Medische Staf, CMM Groep Burgering, Cancer, Circulatory Health, CMM Sectie Molecular Cancer Research, Hubrecht Institute with UMC, Schutgens, Frans, Rookmaaker, Maarten B, Margaritis, Thanasis, Rios, Anne, Ammerlaan, Carola, Jansen, Jitske, Gijzen, Linda, Vormann, Marianne, Vonk, Annelotte, Viveen, Marco, Yengej, Fjodor Yousef, Derakhshan, Sepide, de Winter-de Groot, Karin M, Artegiani, Benedetta, van Boxtel, Ruben, Cuppen, Edwin, Hendrickx, Antoni P A, van den Heuvel-Eibrink, Marry M, Heitzer, Ellen, Lanz, Henriette, Beekman, Jeffrey, Murk, Jean-Luc, Masereeuw, Rosalinde, Holstege, Frank, Drost, Jarno, Verhaar, Marianne C, and Clevers, Hans

Published
2019

26. Tubuloids derived from human adult kidney and urine for personalized disease modeling

Author

Pharmacology, Afd Pharmacology, Sub Developmental Biology, Faculteit Diergeneeskunde, Schutgens, Frans, Rookmaaker, Maarten B, Margaritis, Thanasis, Rios, Anne, Ammerlaan, Carola, Jansen, Jitske, Gijzen, Linda, Vormann, Marianne, Vonk, Annelotte, Viveen, Marco, Yengej, Fjodor Yousef, Derakhshan, Sepide, de Winter-de Groot, Karin M, Artegiani, Benedetta, van Boxtel, Ruben, Cuppen, Edwin, Hendrickx, Antoni P A, van den Heuvel-Eibrink, Marry M, Heitzer, Ellen, Lanz, Henriette, Beekman, Jeffrey, Murk, Jean-Luc, Masereeuw, Rosalinde, Holstege, Frank, Drost, Jarno, Verhaar, Marianne C, Clevers, Hans, Pharmacology, Afd Pharmacology, Sub Developmental Biology, Faculteit Diergeneeskunde, Schutgens, Frans, Rookmaaker, Maarten B, Margaritis, Thanasis, Rios, Anne, Ammerlaan, Carola, Jansen, Jitske, Gijzen, Linda, Vormann, Marianne, Vonk, Annelotte, Viveen, Marco, Yengej, Fjodor Yousef, Derakhshan, Sepide, de Winter-de Groot, Karin M, Artegiani, Benedetta, van Boxtel, Ruben, Cuppen, Edwin, Hendrickx, Antoni P A, van den Heuvel-Eibrink, Marry M, Heitzer, Ellen, Lanz, Henriette, Beekman, Jeffrey, Murk, Jean-Luc, Masereeuw, Rosalinde, Holstege, Frank, Drost, Jarno, Verhaar, Marianne C, and Clevers, Hans

Published
2019

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